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Femtoscopic correlation functions were measured for pp¯¯¯, pΛ¯¯¯¯⊕p¯¯¯Λ, and ΛΛ¯¯¯¯ pairs, as a function of collision centrality, in Pb−Pb collisions at sNN−−−√=2.76 TeV and sNN−−−√=5.02 TeV recorded by the ALICE experiment at the LHC. A simultaneous fit to all obtained correlation functions was performed, maximising the precision and sensitivity to the strong interaction parameters for the selected baryon pairs. Real and imaginary components of the scattering lengths, as well as the effective ranges, were extracted for combined pΛ¯¯¯¯⊕p¯¯¯Λ pairs and, for the first time, for ΛΛ¯¯¯¯ pairs. Effective averaged scattering parameters for heavier baryon−anti-baryon pairs, not measured directly, are also provided. The results reveal similarly strong interaction between measured baryon−anti-baryon pairs, suggesting that they annihilate in the same manner as pp¯¯¯ at the same pair relative momentum k∗. Moreover, the reported significant non-zero imaginary part and negative real part of the scattering length open up a possibility for future baryon−anti-baryon bound state searches.
Two-particle correlation functions were measured for pp¯¯¯, pΛ¯¯¯¯, p¯¯¯Λ, and ΛΛ¯¯¯¯ pairs in Pb-Pb collisions at sNN−−−√=2.76 TeV and sNN−−−√=5.02 TeV recorded by the ALICE detector. From a simultaneous fit to all obtained correlation functions, real and imaginary components of the scattering lengths, as well as the effective ranges, were extracted for combined pΛ¯¯¯¯ and p¯¯¯Λ pairs and, for the first time, for ΛΛ¯¯¯¯ pairs. Effective averaged scattering parameters for heavier baryon-antibaryon pairs, not measured directly, are also provided. The results reveal similarly strong interaction between measured baryon-antibaryon pairs, suggesting that they all annihilate in the same manner at the same pair relative momentum k∗. Moreover, the reported significant non-zero imaginary part and negative real part of the scattering length provide motivation for future baryon-antibaryon bound state searches.
Two-particle correlation functions were measured for pp¯¯¯, pΛ¯¯¯¯, p¯¯¯Λ, and ΛΛ¯¯¯¯ pairs in Pb-Pb collisions at sNN−−−√=2.76 TeV and sNN−−−√=5.02 TeV recorded by the ALICE detector. From a simultaneous fit to all obtained correlation functions, real and imaginary components of the scattering lengths, as well as the effective ranges, were extracted for combined pΛ¯¯¯¯ and p¯¯¯Λ pairs and, for the first time, for ΛΛ¯¯¯¯ pairs. Effective averaged scattering parameters for heavier baryon-antibaryon pairs, not measured directly, are also provided. The results reveal similarly strong interaction between measured baryon-antibaryon pairs, suggesting that they all annihilate in the same manner at the same pair relative momentum k∗. Moreover, the reported significant non-zero imaginary part and negative real part of the scattering length provide motivation for future baryon-antibaryon bound state searches.
We present a study of the inclusive charged-particle transverse momentum (pT) spectra as a function of charged-particle multiplicity density at mid-pseudorapidity, dNch/dη, in pp collisions at s√=5.02 and 13 TeV covering the kinematic range |η|<0.8 and 0.15<pT<20GeV/c. The results are presented for events with at least one charged particle in |η|<1 (INEL >0). The transverse momentum spectra are reported for two multiplicity estimators covering different pseudorapidity regions. While the pT spectra exhibit a strong dependence on multiplicity and center-of-mass energy, they show little energy dependence when normalized to the pT spectrum for INEL >0. The behavior of the multiplicity dependent spectra from intermediate to high transverse momentum (6<pT<20GeV/c) is parametrised by the exponent of a power-law function. Going from low to high average charged-particle density, the exponent decreases from ∼6 to ∼5. Moreover, the high-pT yields of charged particles increase faster than the charged-particle multiplicity density. The average pT as a function of multiplicity and transverse spherocity is reported for pp collisions at s√=13 TeV. For low- (high-) spherocity events, corresponding to jet-like (isotropic) events, the average pT is higher (smaller) than that measured in INEL >0 pp collisions. Within uncertainties, the functional form of ⟨pT⟩(Nch) is not affected by the spherocity selection. While EPOS LHC gives a good description of many features of data, PYTHIA overestimates the average pT in jet-like events. The observations are discussed in terms of multi-parton interactions with large momentum transfer and color reconnection.
We present a study of the inclusive charged-particle transverse momentum (pT) spectra as a function of charged-particle multiplicity density at mid-pseudorapidity, dNch/dη, in pp collisions at s√ = 5.02 and 13 TeV covering the kinematic range |η|<0.8 and 0.15<pT<20 GeV/c. The results are presented for events with at least one charged particle in |η|<1 (INEL>0). The pT spectra are reported for two multiplicity estimators covering different pseudorapidity regions. The pT spectra normalized to that for INEL >0 show little energy dependence. Moreover, the high-pT yields of charged particles increase faster than the charged-particle multiplicity density. The average pT as a function of multiplicity and transverse spherocity is reported for pp collisions at s√=13 TeV. For low- (high-) spherocity events, corresponding to jet-like (isotropic) events, the average pT is higher (smaller) than that measured in INEL >0 pp collisions. Within uncertainties, the functional form of ⟨pT⟩(Nch) is not affected by the spherocity selection. While EPOS LHC gives a good description of many features of data, PYTHIA overestimates the average pT in jet-like events.
In the past two decades, pions created in the high density regions of heavy ion collisions have been predicted to be sensitive at high densities to the symmetry energy term in the nuclear equation of state, a property that is key to our understanding of neutron stars. In a new experiment designed to study the symmetry energy, the multiplicities of negatively and positively charged pions have been measured with high accuracy for central 132Sn+124Sn, 112Sn+124Sn, and 108Sn+112Sn collisions at E/A = 270 MeV with the SπRIT Time Projection Chamber. While individual pion multiplicities are measured to 4% accuracy, those of the charged pion multiplicity ratios are measured to 2% accuracy. We compare these data to predictions from seven major transport models. The calculations reproduce qualitatively the dependence of the multiplicities and their ratios on the total neutron and proton number in the colliding systems. However, the predictions of the transport models from different codes differ too much to allow extraction of reliable constraints on the symmetry energy from the data. This finding may explain previous contradictory conclusions on symmetry energy constraints obtained from pion data in Au+Au system. These new results call for still better understanding of the differences among transport codes, and new observables that are more sensitive to the density dependence of the symmetry energy.
Previous studies in developing Xenopus and zebrafish reported that the phosphate transporter slc20a1a is expressed in pronephric kidneys. The recent identification of SLC20A1 as a monoallelic candidate gene for cloacal exstrophy further suggests its involvement in the urinary tract and urorectal development. However, little is known of the functional role of SLC20A1 in urinary tract development. Here, we investigated this using morpholino oligonucleotide knockdown of the zebrafish ortholog slc20a1a. This caused kidney cysts and malformations of the cloaca. Moreover, in morphants we demonstrated dysfunctional voiding and hindgut opening defects mimicking imperforate anus in human cloacal exstrophy. Furthermore, we performed immunohistochemistry of an unaffected 6-week-old human embryo and detected SLC20A1 in the urinary tract and the abdominal midline, structures implicated in the pathogenesis of cloacal exstrophy. Additionally, we resequenced SLC20A1 in 690 individuals with bladder exstrophy-epispadias complex (BEEC) including 84 individuals with cloacal exstrophy. We identified two additional monoallelic de novo variants. One was identified in a case-parent trio with classic bladder exstrophy, and one additional novel de novo variant was detected in an affected mother who transmitted this variant to her affected son. To study the potential cellular impact of SLC20A1 variants, we expressed them in HEK293 cells. Here, phosphate transport was not compromised, suggesting that it is not a disease mechanism. However, there was a tendency for lower levels of cleaved caspase-3, perhaps implicating apoptosis pathways in the disease. Our results suggest SLC20A1 is involved in urinary tract and urorectal development and implicate SLC20A1 as a disease-gene for BEEC.
Background: In patients with genotype 1 chronic hepatitis C infection, telaprevir (TVR) in combination with peginterferon and ribavirin (PR) significantly increased sustained virologic response (SVR) rates compared with PR alone. However, genotypic changes could be observed in TVR-treated patients who did not achieve an SVR.
Methods: Population sequence analysis of the NS3•4A region was performed in patients who did not achieve SVR with TVR-based treatment.
Results: Resistant variants were observed after treatment with a telaprevir-based regimen in 12% of treatment-naïve patients (ADVANCE; T12PR arm), 6% of prior relapsers, 24% of prior partial responders, and 51% of prior null responder patients (REALIZE, T12PR48 arms). NS3 protease variants V36M, R155K, and V36M+R155K emerged frequently in patients with genotype 1a and V36A, T54A, and A156S/T in patients with genotype 1b. Lower-level resistance to telaprevir was conferred by V36A/M, T54A/S, R155K/T, and A156S variants; and higher-level resistance to telaprevir was conferred by A156T and V36M+R155K variants. Virologic failure during telaprevir treatment was more common in patients with genotype 1a and in prior PR nonresponder patients and was associated with higher-level telaprevir-resistant variants. Relapse was usually associated with wild-type or lower-level resistant variants. After treatment, viral populations were wild-type with a median time of 10 months for genotype 1a and 3 weeks for genotype 1b patients.
Conclusions: A consistent, subtype-dependent resistance profile was observed in patients who did not achieve an SVR with telaprevir-based treatment. The primary role of TVR is to inhibit wild-type virus and variants with lower-levels of resistance to telaprevir. The complementary role of PR is to clear any remaining telaprevir-resistant variants, especially higher-level telaprevir-resistant variants. Resistant variants are detectable in most patients who fail to achieve SVR, but their levels decline over time after treatment.
Inclusive neutron spectra were measured at 0°, 4°, 8°, 15°, 30°, and 42° from Nb-Nb and Au-Au collisions at 800 MeV/nucleon. A peak that originates from neutron evaporation from the projectile appears in the spectra at angles out to 8°. The shapes and magnitudes of the spectra are compared with those calculated from models of nucleus-nucleus collisions. The differential cross sections for Au-Au collisions are about four times those for Nb-Nb collisions. The predictions of the Vlasov-Uehling-Uhlenbeck (VUU) and QMD theories agree with the angular distributions of the differential cross sections except at small angles; the VUU prediction overestimates the angular distributions from a few degrees to about 20°, whereas the QMD prediction underestimates the angular distributions below 8°. The Firestreak model overestimates the angular distribution for Nb-Nb collisions and underestimates it for Au-Au collisions. Also, the VUU and QMD models agree with the measured double-differential cross sections in more angular and energy regions than the Firestreak and intranuclear cascade models; however, none of the models can account for the peaks at small angles (θ≤15°).