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Abelev, Betty ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Anderson, Bryon D. ; Arkhipkin, Dmitry A. ; Averichev, Georgy S. ; Balewski, Jan ; Barannikova, Olga ; Barnby, Lee Stuart ; Baudot, Jérome ; Baumgart, S. ; Beavis, D. R. ; Bellwied, Rene ; Benedosso, F. ; Betancourt, M. J. ; Betts, R. R. ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bichsel, Hans ; Bielčík, Jaroslav ; Bielčíková, Jana ; Biritz, B. ; Bland, Leslie C. ; Bombara, Marek ; Bonner, Billy E. ; Botje, Michiel ; Bouchet, J. ; Braidot, E. ; Brandin, Andrei V. ; Bruna, Elena ; Bueltmann, S. ; Burton, T. P. ; Bystersky, M. ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Catu, O. ; Cebra, Daniel A. ; Cendejas, R. ; Cervantes, M. C. ; Chajecki, Z. ; Chaloupka, Petr ; Chattopadhyay, S. ; Chen, H. F. ; Chen, J. H. ; Chen, J. Y. ; Cheng, J. ; Cherney, Michael Gerard ; Chikanian, Alexei ; Choi, K. E. ; Christie, William ; Clarke, R. F. ; Codrington, M. J. 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S. ; Wang, Q. ; Wang, X. ; Wang, X. L. ; Wang, Y. ; Webb, Grant ; Webb, Jason C. ; Westfall, Gary D. ; Whitten, Charles A. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xie, W. ; Xu, N. ; Xu, Qinghua ; Xu, Y. ; Xu, Z. ; Yang, Y. ; Yepes, Pablo P. ; Yip, K. ; Yoo, I. -K. ; Yue, Q. ; Zawisza, M. ; Zbroszczyk, Hanna Paulina ; Zhan, W. ; Zhang, S. ; Zhang, W. M. ; Zhang, X. P. ; Zhang, Y. ; Zhang, Z. P. ; Zhao, Y. ; Zhong, C. ; Zhou, J. ; Zoulkarneev, R. ; Zoulkarneeva, Youlia ; Zuo, J. X.
The STAR Collaboration at the Relativistic Heavy Ion Collider presents measurements of 𝐽/𝜓→𝑒+𝑒− at midrapidity and high transverse momentum (𝑝𝑇>5 GeV/𝑐) in 𝑝+𝑝 and central Cu+Cu collisions at √𝑠𝑁𝑁=200 GeV. The inclusive 𝐽/𝜓 production cross section for Cu+Cu collisions is found to be consistent at high 𝑝𝑇 with the binary collision-scaled cross section for 𝑝+𝑝 collisions. At a confidence level of 97%, this is in contrast to a suppression of 𝐽/𝜓 production observed at lower 𝑝𝑇. Azimuthal correlations of 𝐽/𝜓 with charged hadrons in 𝑝+𝑝 collisions provide an estimate of the contribution of 𝐵-hadron decays to 𝐽/𝜓 production of 13%±5%.
Abelev, Betty ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Anderson, Bryon D. ; Arkhipkin, Dmitry A. ; Averichev, Georgy S. ; Bai, Y. ; Balewski, Jan ; Barannikova, Olga ; Barnby, Lee Stuart ; Baudot, Jérome ; Baumgart, S. ; Beavis, D.R. ; Bellwied, Rene ; Benedosso, F. ; Betancourt, M.J. ; Betts, R.R. ; Bharadwaj, Somnath ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bichsel, Hans ; Bielčík, Jaroslav ; Bielčíková, Jana ; Biritz, B. ; Bland, Leslie C. ; Bombara, Marek ; Bonner, B.E. ; Botje, Michiel ; Bouchet, J. ; Braidot, E. ; Brandin, Andrei V. ; Bruna, Elena ; Bueltmann, S. ; Burton, T.P. ; Bystersky, M. ; Cai, X.Z. ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Callner, J. ; Catu, O. ; Cebra, Daniel A. ; Cendejas, R. ; Cervantes, M.C. ; Chajecki, Z. ; Chaloupka, Petr ; Chattopadhyay, S. ; Chen, H.F. ; Chen, J.H. ; Chen, J.Y. ; Cheng, J. ; Cherney, Michael Gerard ; Chikanian, Alexei ; Choi, K.E. ; Christie, William ; Chung, Suh-Urk ; Clarke, R.F. ; Codrington, M.J. ; Coffin, Jean Pierre ; Corliss, R. ; Cormier, Thomas Michael ; Cosentino, Mauro Rogerio ; Cramer, John G. ; Crawford, Henry J. ; Das, Debasish ; Dash, Sadhana ; Daugherity, M. ; De Silva, C. ; Dedovič, Tatiana G. ; DePhillips, M. ; Derevschikov, Anatoly A. ; Souza, Rafael Derradi de ; Didenko, Lidia ; Djawotho, P. ; Dogra, Sunil Manohar ; Dong, X. ; Drachenberg, James Lucus ; Draper, James E. ; Du, F. ; Dunlop, James C. ; Dutta Mazumdar, M.R. ; Edwards, W.R. ; Efimov, Leonid G. ; Elhalhuli, E. ; Elnimr, M. ; Emelianov, V. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Erazmus, Barbara Ewa ; Estienne, Magali Danielle ; Eun, L. ; Fachini, Patricia ; Fatemi, Renee H. ; Fedorišin, Jan ; Feng, A. ; Filip, Peter ; Finch, Evan ; Fine, Valeri ; Fisyak, Yuri V. ; Gagliardi, Carl A. ; Gaillard, L. ; Gangadharan, Dhevan Raja ; Ganti, Murthy S. ; Garcia-Solis, Edmundo Javier ; Ghazikhanian, Vahe ; Ghosh, Premomoy ; Gorbunov, Y.N. ; Gordon, A. ; Grebenyuk, Oleksandr ; Grosnick, David P. ; Grube, B. ; Guertin, Steven M. ; Guimaraes, K.S.F.F. ; Gupta, Anik ; Gupta, N. ; Guryn, Włodzimierz ; Haag, B. ; Hallman, Timothy J. ; Hamed, Ahmed M. ; Harris, John W. ; He, W. ; Heinz, Mark Thomas ; Hepplemann, S. ; Hippolyte, Boris ; Hirsch, Andrew S. ; Hjort, Eric ; Hoffman, A.M. ; Hoffmann, Gerald W. ; Hofman, D.J. ; Hollis, R.S. ; Huang, Huan Zhong ; Humanic, Thomas J. ; Igo, George J. ; Iordanova, A. ; Jacobs, P. ; Jacobs, William W. ; Jakl, P. ; Jin, F. ; Jones, C.L. ; Jones, Peter Graham ; Joseph, J. ; Judd, Eleanor G. ; Kabana, Sonia ; Kajimoto, K. ; Kang, K. ; Kapitan, J. ; Kaplan, Morton ; Keane, Declan ; Kechechyan, Armen ; Kettler, D. ; Khodyrev, V.Yu. ; Kikola, D.P. ; Kiryluk, Joanna ; Kisiel, Adam Ryszard ; Klein, Spencer Robert ; Knospe, Anders Garritt ; Kocoloski, A. ; Koetke, Donald D. ; Kopytine, M. ; Kotchenda, L. ; Kouchpil, V. ; Kravtsov, Peter ; Kravtsov, Vladimir I. ; Krueger, Keith William ; Krus, M. ; Kuhn, Christian Claude ; Kumar, Lokesh ; Kurnadi, P. ; Lamont, Matthew A. C. ; Landgraf, Jeffery M. ; LaPointe, S. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, C.-H. ; Leight, W. ; LeVine, Micheal J. ; Li, C. ; Li, Y. ; Lin, G. ; Lin, X. ; Lindenbaum, Sam J. ; Lisa, Michael A. ; Liu, F. ; Liu, H. ; Liu, J. ; Liu, L. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Longacre, Ronald S. ; Love, William A. ; Lu, Y. ; Ludlam, Thomas ; Lynn, David ; Ma, G.L. ; Ma, Yu-Gang ; Mahapatra, Durga Prasad ; Majka, Richard Daniel ; Mall, O.I. ; Mangotra, L.K. ; Manweiler, Robert W. ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Matulenko, Yu.A. ; McShane, Tom S. ; Meščanin, Aleksei P. ; Millner, R. ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mischke, André ; Mitchell, J. ; Mohanty, Bedangadas ; Morozov, Dmitry A. ; Munhoz, Marcelo Gameiro ; Nandi, Basanta Kumar ; Nattrass, Christine ; Nayak, Tapan Kumar ; Nelson, John M. ; Nepali, C. ; Netrakanti, Pawan Kumar ; Ng, M.J. ; Nogach, Larisa V. ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Okada, H. ; Okorokov, Vitaly A. ; Olson, Douglas L. ; Pachr, Miloš ; Page, Brian S. ; Pal, Susanta Kumar ; Pandit, Y. ; Panebratsev, Yuri ; Pawlak, Tomasz Jan ; Peitzmann, Thomas ; Perevoztchikov, V. ; Perkins, Chris ; Peryt, Wiktor Stanislaw ; Phatak, S.C. ; Planinic, Mirko ; Pluta, Jan Marian ; Poljak, Nikola ; Poskanzer, Arthur M. ; Potukuchi, B.V.K.S. ; Prindle, Duncan J. ; Pruneau, Claude A. ; Pruthi, Navneet Kumar ; Putschke, Jörn H. ; Raniwala, Rashmi ; Raniwala, Sudhir ; Ray, Robert L. ; Redwine, R. ; Reed, Rosi Jan ; Ridiger, Alexey ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Rose, A. ; Roy, Christelle Sophie ; Ruan, L. ; Russcher, M.J. ; Rykov, Vladimir L. ; Sahoo, Raghunath ; Sakrejda, Iwona ; Sakuma, T. ; Salur, Sevil ; Sandweiss, Jack H. ; Sarsour, M. ; Savin, Igor A. ; Schambach, Joachim ; Scharenberg, Rolf Paul ; Schmitz, Norbert ; Seger, Janet Elizabeth ; Selyuzhenkov, Ilya ; Seyboth, Peter ; Shabetai, Alexandre ; Shahaliev, Ehtiram ; Shao, M. ; Sharma, M. ; Shi, Shusu ; Shi, X.-H. ; Sichtermann, Ernst P. ; Simon, F. ; Singaraju, Rama Narayana ; Skoby, Michael J. ; Smirnov, Nikolai ; Snellings, Raimond ; Sorensen, Paul Richard ; Sowinski, James ; Spinka, Harold. M. ; Srivastava, B. ; Stadnik, A. ; Stanislaus, T. D. Shirvel ; Staszak, D. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Suarez, M.C. ; Subba, N.L. ; Šumbera, Michal ; Sun, X.M. ; Sun, Y. ; Sun, Z. ; Surrow, Bernd ; Symons, Timothy James MacNeil ; Toledo, Alejandro Szanto de ; Takahashi, Jun ; Tang, Aihong ; Tang, Zebo ; Tarnowsky, Terence J. ; Thein, Dylan ; Thomas, James H. ; Tian, J. ; Timmins, Anthony Robert ; Timoshenko, Sergei ; Tlusty, David ; Tokarev, Mikhail V. ; Trainor, T.A. ; Tram, V.N. ; Trattner, A.L. ; Trentalange, Stephen ; Tribble, Robert E. ; Tsai, Oleg D. ; Ulery, Jason Glyndwr ; Ullrich, Thomas ; Underwood, David G. ; Van Buren, Gene ; Leeuwen, Marco van ; Vander Molen, A.M. ; Vanfossen, J.A. ; Varma, Raghava ; Vasconcelos, G.M.S. ; Vasilevski, I.M. ; Vasiliev, Alexander Nikolaevich ; Videbæk, Flemming ; Vigdor, Steven E. ; Viyogi, Yogendra P. ; Vokal, Stanislav ; Voloshin, Sergei ; Wada, M. ; Waggoner, William T. ; Walker, M. ; Wang, F. ; Wang, G. ; Wang, J.S. ; Wang, Q. ; Wang, X. ; Wang, X.L. ; Wang, Y. ; Webb, Jason C. ; Westfall, Gary D. ; Whitten, Charles A. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xu, N. ; Xu, Qinghua ; Xu, Y. ; Xu, Z. ; Yepes, Pablo P. ; Yoo, In-Kwon ; Yue, Q. ; Zawisza, M. ; Zbroszczyk, Hanna Paulina ; Zhan, W. ; Zhang, H. ; Zhang, S. ; Zhang, W.M. ; Zhang, Y. ; Zhang, Z.P. ; Zhao, Y. ; Zhong, C. ; Zhou, J. ; Zoulkarneev, R. ; Zoulkarneeva, Youlia ; Zuo, J.X.
We study the beam-energy and system-size dependence of \phi meson production (using the hadronic decay mode \phi -- K+K-) by comparing the new results from Cu+Cu collisions and previously reported Au+Au collisions at \sqrt{s_NN} = 62.4 and 200 GeV measured in the STAR experiment at RHIC. Data presented are from mid-rapidity (|y|<0.5) for 0.4 < pT < 5 GeV/c. At a given beam energy, the transverse momentum distributions for \phi mesons are observed to be similar in yield and shape for Cu+Cu and Au+Au colliding systems with similar average numbers of participating nucleons. The \phi meson yields in nucleus-nucleus collisions, normalised by the average number of participating nucleons, are found to be enhanced relative to those from p+p collisions with a different trend compared to strange baryons. The enhancement for \phi mesons is observed to be higher at \sqrt{s_NN} = 200 GeV compared to 62.4 GeV. These observations for the produced \phi(s\bar{s}) mesons clearly suggest that, at these collision energies, the source of enhancement of strange hadrons is related to the formation of a dense partonic medium in high energy nucleus-nucleus collisions and cannot be alone due to canonical suppression of their production in smaller systems.
Hudson, Lawrence N. ; Newbold, Tim ; Contu, Sara ; Hill, Samantha L. L. ; Lysenko, Igor ; Palma, Adriana de ; Phillips, Helen R. P. ; Senior, Rebecca A. ; Bennett, Dominic J. ; Booth, Hollie ; Choimes, Argyrios ; Correia, David L. P. ; Day, Julie ; Echeverria-Londono, Susy ; Garon, Morgan ; Harrison, Michelle L. K. ; Ingram, Daniel J. ; Jung, Martin ; Kemp, Victoria ; Kirkpatrick, Lucinda ; Martin, Callum D. ; Pan, Yuan ; White, Hannah J. ; Aben, Job ; Abrahamczyk, Stefan ; Adum, Gilbert B. ; Aguilar-Barquero, Virginia ; Aizen, Marcelo ; Ancrenaz, Marc ; Arbelaez-Cortes, Enrique ; Armbrecht, Inge ; Azhar, Badrul ; Azpiroz, Adrián B. ; Baeten, Lander ; Báldi, András ; Banks, John E. ; Barlow, Jos ; Batáry, Péter ; Bates, Adam J. ; Bayne, Erin M. ; Beja, Pedro ; Berg, Åke ; Berry, Nicholas J. ; Bicknell, Jake E. ; Bihn, Jochen H. ; Böhning-Gaese, Katrin ; Boekhout, Teun ; Boutin, Celine ; Bouyer, Jeremy ; Brearley, Francis Q. ; Brito, Isabel ; Brunet, Jörg ; Buczkowski, Grzegorz ; Buscardo, Erika ; Cabra-Garcia, Jimmy ; Calvino-Cancela, Maria ; Cameron, Sydney A. ; Cancello, Eliana M. ; Carrijo, Tiago F. ; Carvalho, Anelena L. ; Castro, Helena ; Castro-Luna, Alejandro Antonio ; Cerda, Rolando ; Cerezo, Alexis ; Chauvat, Matthieu ; Clarke, Frank M. ; Cleary, Daniel F. R. ; Connop, Stuart P. ; D'Aniello, Biagio ; Silva, Pedro Giovani da ; Darvill, Ben ; Dauber, Jens ; Dejean, Alain ; Diekötter, Tim ; Dominguez-Haydar, Yamileth ; Dormann, Carsten F. ; Dumont, Bertrand ; Dures, Simon G. ; Dynesius, Mats ; Edenius, Lars ; Elek, Zoltan ; Entling, Martin H. ; Farwig, Nina ; Fayle, Tom M. ; Felicioli, Antonio ; Felton, Annika M. ; Ficetola, Gentile Francesco ; Filgueiras, Bruno K. C. ; Fonte, Steve J. ; Fraser, Lauchlan H. ; Fukuda, Daisuke ; Furlani, Dario ; Ganzhorn, Jörg U. ; Garden, Jenni G. ; Gheler-Costa, Carla ; Giordani, Paolo ; Giordano, Simonetta ; Gottschalk, Marco S. ; Goulson, Dave ; Gove, Aaron D. ; Grogan, James ; Hanley, Mick E. ; Hanson, Thor ; Hashim, Nor R. ; Hawes, Joseph E. ; Hébert, Christian ; Helden, Alvin J. ; Henden, John-André ; Hernández, Lionel ; Herzog, Felix ; Higuera-Diaz, Diego ; Hilje, Branko ; Horgan, Finbarr G. ; Horvath, Roland ; Hylander, Kristoffer ; Horvath, Roland ; Isaacs-Cubides, Paola ; Ishitani, Mashiro ; Jacobs, Carmen T. ; Jaramillo, Victor J. ; Jauker, Birgit ; Jonsell, Matts ; Jung, Thomas S. ; Kapoor, Vena ; Kati, Vassiliki ; Katovai, Eric ; Kessler, Michael ; Knop, Eva ; Kolb, Annette ; Körösi, Àdám ; Lachat, Thibault ; Lantschner, Victoria ; Le Féon, Violette ; LeBuhn, Gretchen ; Légaré, Jean-Philippe ; Letcher, Susan G. ; Littlewood, Nick A. ; López-Quintero, Carlos A. ; Louhaichi, Mounir ; Lövei, Gabor L. ; Lucas-Borja, Manuel Esteban ; Luja, Victor H. ; Maeto, Kaoru ; Magura, Tibor ; Mallari, Neil Aldrin D. ; Marin-Spiotta, Erika ; Marshall, Edward Jon P. ; Martínez, Eliana ; Mayfield, Margaret M. ; Mikusinski, Gregorz ; Milder, Jeffery C. ; Miller, James R. ; Morales, Carolina L. ; Muriithi-Muchane, Mary Nyawira ; Muchane, Muchai ; Naidoo, Robin ; Nakamura, Akihiro ; Naoe, Shoji ; Nates-Parra, Guiomar ; Navarerete Gutierrez, Dario A. ; Neuschulz, Eike Lena ; Noreika, Norbertas ; Norfolk, Olivia ; Noriega, Jorge Ari ; Nöske, Nicole M. ; O'Dea, Niall ; Oduro, William ; Ofori-Boateng, Caleb ; Oke, Chris O. ; Osgathorpe, Lynne M. ; Paritsis, Juan ; Parrah, Alejandro ; Pelegrin, Nicolás ; Peres, Carlos A. ; Persson, Anna S. ; Petanidou, Theodora ; Phalan, Ben ; Philips, T. Keith ; Poveda, Katja ; Power, Eileen F. ; Presley, Steven J. ; Proença, Vânia ; Quaranta, Marino ; Quintero, Carolina ; Redpath-Downing, Nicola A. ; Reid, J. Leighton ; Reis, Yana T. ; Ribeiro, Danilo B. ; Richardson, Barbara A. ; Richardson, Michael J. ; Robles, Carolina A. ; Römbke, Jörg ; Romero-Duque, Luz Piedad ; Rosselli, Loreta ; Rossiter, Stephen J. ; Roulston, T'ai H. ; Rousseau, Laurent ; Sadler, Jonathan P. ; Sáfián, Szbolcs ; Saldaña-Vásquez, Romeo A. ; Samnegård, Ulrika ; Schüepp, Christof ; Schweiger, Oliver ; Sedlock, Jodi L. ; Shahabuddin, Ghazala ; Sheil, Douglas ; Silva, Fernando A. B. ; Slade, Eleanor ; Smith-Pardo, Allan H. ; Sodhi, Navjot S. ; Somarriba, Eduardo J. ; Sosa, Ramón A. ; Stout, Jane C. ; Struebig, Matthew J. ; Sung, Yik-Hei ; Threlfall, Caragh G. ; Tonietto, Rebecca ; Tóthmérész, Béla ; Tscharntke, Teja ; Turner, Edgar C. ; Tylianakis, Jason M. ; Vanbergen, Adam J. ; Vassilev, Kiril ; Verboven, Hans A. F. ; Vergara, Carlos H. ; Vergara, Pablo M. ; Verhulst, Jort ; Walker, Tony R. ; Wang, Yanping ; Watling, James I. ; Wells, Konstans ; Williams, Christopher D. ; Willig, Michael R. ; Woinarski, John Casimir Zichy ; Wolf, Jan H. D. ; Woodcock, Ben A. ; Yu, Douglas W. ; Zailsev, Andreys ; Collen, Ben ; Ewers, Rob M. ; Mace, Georgina M. ; Purves, Drew W. ; Scharlemann, Jörn P. W. ; Pervis, Andy
Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species’ threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project – and avert – future declines. We describe and assess a new database of more than 1.6 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world. The database contains measurements taken in 208 (of 814) ecoregions, 13 (of 14) biomes, 25 (of 35) biodiversity hotspots and 16 (of 17) megadiverse countries. The database contains more than 1% of the total number of all species described, and more than 1% of the described species within many taxonomic groups – including flowering plants, gymnosperms, birds, mammals, reptiles, amphibians, beetles, lepidopterans and hymenopterans. The dataset, which is still being added to, is therefore already considerably larger and more representative than those used by previous quantitative models of biodiversity trends and responses. The database is being assembled as part of the PREDICTS project (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems – www.predicts.org.uk). We make site-level summary data available alongside this article. The full database will be publicly available in 2015.
Kennedy, Eamonn ; Vadlamani, Shashank ; Lindsey, Hannah M. ; Lei, Pui-Wa ; Jo-Pugh, Mary ; Adamson, Maheen ; Alda, Martin ; Alonso-Lana, Silvia ; Ambrogi, Sonia ; Anderson, Tim J. ; Arango, Celso ; Asarnow, Robert F. ; Avram, Mihai ; Ayesa-Arriola, Rosa ; Babikian, Talin ; Banaj, Nerisa ; Bird, Laura J. ; Borgwardt, Stefan ; Brodtmann, Amy ; Brosch, Katharina ; Caeyenberghs, Karen ; Calhoun, Vince D. ; Chiaravalloti, Nancy D. ; Cifu, David X. ; Crespo-Facorro, Benedicto ; Dalrymple-Alford, John C. ; Dams-O’Connor, Kristen ; Dannlowski, Udo ; Darby, David ; Davenport, Nicholas ; DeLuca, John ; Díaz-Caneja, Covadonga M. ; Disner, Seth G. ; Dobryakova, Ekaterina ; Ehrlich, Stefan ; Esopenko, Carrie ; Ferrarelli, Fabio ; Frank, Lea E. ; Franz, Carol ; Fuentes-Claramonte, Paola ; Genova, Helen ; Giza, Christopher C. ; Goltermann, Janik ; Grotegerd, Dominik ; Gruber, Marius ; Gutiérrez-Zotes, Alfonso ; Ha, Minji ; Haavik, Jan ; Hinkin, Charles ; Hoskinson, Kristen R. ; Hubl, Daniela ; Irimia, Andrei ; Jansen, Andreas ; Kaess, Michael ; Kang, Xiaojian ; Kenney, Kimbra ; Keřková, Barbora ; Khlif, Mohamed Salah ; Kim, Minah ; Kindler, Jochen ; Kircher, Tilo ; Knı́žková, Karolina ; Kolskår, Knut K. ; Krch, Denise ; Kremen, William S. ; Kuhn, Taylor ; Kumari, Veena ; Kwon, Jun Soo ; Langella, Roberto ; Laskowitz, Sarah ; Lee, Jungha ; Lengenfelder, Jean ; Liebel, Spencer W. ; Liou-Johnson, Victoria ; Lippa, Sara M. ; Løvstad, Marianne ; Lundervold, Astri ; Marotta, Cassandra ; Marquardt, Craig A. ; Mattos, Paulo ; Mayeli, Ahmad ; McDonald, Carrie R. ; Meinert, Susanne ; Melzer, Tracy R. ; Merchán Naranjo, Jessica ; Michel, Chantal ; Morey, Rajendra A. ; Mwangi, Benson ; Myall, Daniel J. ; Nenadić, Igor ; Newsome, Mary R. ; Nunes, Abraham ; O’Brien, Terence J. ; Oertel, Viola ; Ollinger, John ; Olsen, Alexander ; Ortiz Garcı́a de la Foz, Victor ; Ozmen, Mustafa ; Pardoe, Heath ; Parent, Marise ; Piras, Fabrizio ; Piras, Federica ; Pomarol-Clotet, Edith ; Repple, Jonathan ; Richard, Geneviève ; Rodriguez, Jonathan ; Rodriguez, Mabel ; Rootes-Murdy, Kelly ; Rowland, Jared ; Ryan, Nicholas P. ; Salvador, Raymond ; Sanders, Anne-Marthe ; Schmidt, André ; Soares, Jair C. ; Spalleta, Gianfranco ; Španiel, Filip ; Stasenko, Alena ; Stein, Frederike ; Straube, Benjamin ; Thames, April ; Thomas-Odenthal, Florian ; Thomopoulos, Sophia I. ; Tone, Erin ; Torres, Ivan ; Troyanskaya, Maya ; Turner, Jessica A. ; Ulrichsen, Kristine M. ; Umpierrez, Guillermo ; Vilella, Elisabet ; Vivash, Lucy ; Walker, William C. ; Werden, Emilio ; Westlye, Lars T. ; Wild, Krista ; Wroblewski, Adrian ; Wu, Mon-Ju ; Wylie, Glenn R. ; Yatham, Lakshmi N. ; Zunta-Soares, Giovana B. ; Thompson, Paul M. ; Tate, David F. ; Hillary, Frank G. ; Dennis, Emily L. ; Wilde, Elisabeth A.
Investigators in the cognitive neurosciences have turned to Big Data to address persistent replication and reliability issues by increasing sample sizes, statistical power, and representativeness of data. While there is tremendous potential to advance science through open data sharing, these efforts unveil a host of new questions about how to integrate data arising from distinct sources and instruments. We focus on the most frequently assessed area of cognition - memory testing - and demonstrate a process for reliable data harmonization across three common measures. We aggregated raw data from 53 studies from around the world which measured at least one of three distinct verbal learning tasks, totaling N = 10,505 healthy and brain-injured individuals. A mega analysis was conducted using empirical bayes harmonization to isolate and remove site effects, followed by linear models which adjusted for common covariates. After corrections, a continuous item response theory (IRT) model estimated each individual subject’s latent verbal learning ability while accounting for item difficulties. Harmonization significantly reduced inter-site variance by 37% while preserving covariate effects. The effects of age, sex, and education on scores were found to be highly consistent across memory tests. IRT methods for equating scores across AVLTs agreed with held-out data of dually-administered tests, and these tools are made available for free online. This work demonstrates that large-scale data sharing and harmonization initiatives can offer opportunities to address reproducibility and integration challenges across the behavioral sciences.
Adamczyk, Leszek ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alekseev, Igor G. ; Alford, Jeremy ; Anson, Christopher Daniel ; Aparin, Alexey ; Arkhipkin, Dmitry A. ; Aschenauer, Elke Caroline ; Averichev, Georgy S. ; Balewski, Jan ; Banerjee, A. ; Barnovska-Blenessy, Zuzana ; Beavis, Dana Richard ; Bellwied, Rene ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bhattarai, P. ; Bichsel, Hans ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Borowski, W. ; Bouchet, Jonathan ; Brandin, Andrei V. ; Brovko, Samantha G. ; Bültmann, Stephen L. ; Bunzarov, Ivan ; Burton, T.P. ; Butterworth, Joseph ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Cendejas, R. ; Cervantes, M.C. ; Chaloupka, Petr ; Chang, Z. ; Chattopadhyay, S. ; Chen, H.F. ; Chen, J.H. ; Chen, L. ; Cheng, J. ; Cherney, Michael Gerard ; Chikanian, Alexei ; Christie, William ; Chwastowski, J. ; Codrington, M.J.M. ; Corliss, R. ; Cramer, John G. ; Crawford, Henry J. ; Cui, X. ; Das, Supriya ; Davila Leyva, A. ; De Silva, L.C. ; Debbe, R.R. ; Dedovič, Tatiana G. ; Deng, J. ; Derevschikov, Anatoly A. ; Souza, Rafael Derradi de ; Dhamija, S. ; di Ruzza, Benedetto ; Didenko, Lidia ; Dilks, Christopher ; Ding, F. ; Djawotho, P. ; Dong, X. ; Drachenberg, James Lucus ; Draper, James E. ; Du, C.M. ; Dunkelberger, Lloyd Edward ; Dunlop, James C. ; Efimov, Leonid G. ; Engelage, Jon M. ; Engle, K.S. ; Eppley, Geary Wareham ; Eun, L. ; Evdokimov, Olga Y. ; Fatemi, Renee H. ; Fazio, Salvatore ; Fedorišin, Jan ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Flores, C.E. ; Gagliardi, Carl A. ; Gangadharan, Dhevan Raja ; Garand, David ; Geurts, Frank ; Gibson, Adam ; Girard, M. ; Gliske, S. ; Grosnick, David P. ; Guo, Y. ; Gupta, Anik ; Gupta, S. ; Guryn, Włodzimierz ; Haag, B. ; Hajkova, O. ; Hamed, Ahmed M. ; Han, L.-X. ; Haque, R. ; Harris, John W. ; Hays-Wehle, James P. ; Heppelmann, Steven Francis ; Hirsch, Andrew S. ; Hoffmann, Gerald W. ; Hofman, D.J. ; Horvat, S. ; Huang, B. ; Huang, H.Z. ; Huang, X. ; Huck, Patrick ; Humanic, Thomas J. ; Igo, George J. ; Jacobs, William W. ; Jang, H. ; Judd, Eleanor G. ; Kabana, Sonia ; Kalinkin, Dmitry ; Kang, K. ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kesich, A. ; Khan, Z.H. ; Kikola, D.P. ; Kisel, Ivan ; Kisiel, Adam Ryszard ; Koetke, Donald D. ; Kollegger, Thorsten ; Konzer, J. ; Koralt, I. ; Korsch, Wolfgang K. ; Kotchenda, L. ; Kravtsov, Peter ; Krueger, Keith William ; Kulakov, Igor ; Kumar, Lokesh ; Kycia, R.A. ; Lamont, Matthew A. C. ; Landgraf, Jeffery M. ; Landry, K.D. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J.H. ; Leight, W. ; LeVine, Micheal J. ; Li, C. ; Li, W. ; Li, Xiaomei ; Li, Xiaomei ; Li, Y. ; Li, Z.M. ; Lima, L.M. ; Lisa, Michael A. ; Liu, F. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Longacre, Ronald S. ; Luo, X. ; Ma, G.L. ; Ma, Yu-Gang ; Madagodagettige Don, D.M.M.D. ; Mahapatra, Durga Prasad ; Majka, Richard Daniel ; Margetis, Spyridon ; Markert, Christina ; Masui, H. ; Matis, Howard S. ; McDonald, Daniel ; McShane, Tom S. ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mohanty, Bedangadas ; Mondal, Mriganka Mouli ; Morozov, Dmitry A. ; Munhoz, Marcelo Gameiro ; Mustafa, M.K. ; Nandi, Basanta Kumar ; Nasim, Md. ; Nayak, Tapan Kumar ; Nelson, John M. ; Nogach, Larisa V. ; Noh, S.Y. ; Novak, J. ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Kunsu ; Ohlson, Alice ; Okorokov, Vitaly A. ; Oldag, E.W. ; Oliveira, Renato Aparecido Negrao de ; Pachr, Miloš ; Page, Brian S. ; Pal, Susanta Kumar ; Pan, Y.X. ; Pandit, Y. ; Panebratsev, Yuri ; Pawlak, Tomasz Jan ; Pawlik, Bogdan ; Pei, Hua ; Perkins, Chris ; Peryt, Wiktor Stanislaw ; Pile, P. ; Planinic, Mirko ; Pluta, Jan Marian ; Plyku, Donika ; Poljak, Nikola ; Porter, Jeffrey Brent ; Poskanzer, Arthur M. ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Pujahari, Prabhat Ranjan ; Qiu, H. ; Quintero, Amilkar ; Ramachandran, Suvarna ; Raniwala, Rashmi ; Raniwala, Sudhir ; Ray, Robert L. ; Riley, C.K. ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Ross, J.F. ; Roy, Ankhi ; Ruan, Lijuan ; Rusnak, Jan ; Sahoo, Nihar Ranjan ; Sahu, Pradip Kumar ; Sakrejda, Iwona ; Salur, Sevil ; Sandacz, Andrzej ; Sandweiss, Jack H. ; Sangaline, Evan ; Sarkar, Amal ; Schambach, Joachim ; Scharenberg, Rolf Paul ; Schmah, Alexander ; Schmidke, William B. ; Schmitz, Norbert ; Seger, Janet Elizabeth ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Sharma, B. ; Shen, W.Q. ; Shi, S.S. ; Shou, Q.Y. ; Sichtermann, Ernst P. ; Singaraju, Rama Narayana ; Skoby, M.J. ; Smirnov, Dmitri V. ; Smirnov, Nikolai ; Solanki, D. ; Sorensen, Paul Richard ; Souza, Ulisses Gulart de ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stevens, J.R. ; Stock, Reinhard ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Šumbera, Michal ; Sun, X. ; Sun, X.M. ; Sun, Y. ; Sun, Z. ; Surrow, Bernd ; Svirida, Dmitry N. ; Symons, Timothy James MacNeil ; Toledo, Alejandro Szanto de ; Takahashi, Jun ; Tang, Aihong ; Tang, Zebo ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Tokarev, Mikhail V. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Trzeciak, Barbara Antonina ; Tsai, Oleg D. ; Turnau, J. ; Ullrich, Thomas ; Underwood, David G. ; Van Buren, Gene ; Nieuwenhuizen, Gerrit J. van ; Vanfossen, Joseph A. ; Varma, Raghava ; Vasconcelos, Geraldo M. S. ; Vasiliev, Alexander Nikolaevich ; Vértesi, Róbert ; Videbæk, Flemming ; Viyogi, Yogendra P. ; Vokal, Stanislav ; Vossen, A. ; Wada, M. ; Walker, M. ; Wang, F. ; Wang, G. ; Wang, H. ; Wang, J.S. ; Wang, X.L. ; Wang, Y. ; Wang, Y. ; Webb, Grant ; Webb, Jason C. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y.F. ; Xiao, Z. ; Xie, W. ; Xin, K. ; Xu, H. ; Xu, N. ; Xu, Qinghua ; Xu, Y. ; Xu, Z. ; Yan, W. ; Yang, C. ; Yang, Y. ; Yang, Y. ; Ye, Z. ; Yepes, Pablo P. ; Yi, L. ; Yip, K. ; Yoo, In-Kwon ; Zawisza, Y. ; Zbroszczyk, Hanna Paulina ; Zha, W. ; Zhang, J.B. ; Zhang, J.L. ; Zhang, S. ; Zhang, X.P. ; Zhang, Y. ; Zhang, Z.P. ; Zhao, F. ; Zhao, J. ; Zhong, C. ; Zhu, X. ; Zhu, Y.H. ; Zoulkarneeva, Youlia ; Zyzak, Maksym
We report on a polarization measurement of inclusive J/ψ mesons in the di-electron decay channel at mid-rapidity at 2 < pT < 6 GeV/c in p + p collisions at √s = 200 GeV. Data were taken with the STAR detector at RHIC. The J/ψ polarization measurement should help to distinguish between different models of the J/ψ production mechanism since they predict different pT dependences of the J/ψ polarization. In this analysis, J/ψ polarization is studied in the helicity frame. The polarization parameter λθ measured at RHIC becomes smaller towards high pT , indicating more longitudinal J/ψ polarization as pT increases. The result is compared with predictions of presently available models.
Kashani, Kianoush ; Al-Khafaji, Ali ; Ardiles, Thomas ; Artigas, Antonio ; Bagshaw, Sean M. ; Bell, Max ; Bihorac, Azra ; Birkhahn, Robert ; Cely, Cynthia M. ; Chawla, Lakhmir S. ; Davison, Danielle L. ; Feldkamp, Thorsten ; Forni, Lui G. ; Gong, Michelle Ng ; Gunnerson, Kyle J. ; Haase, Michael ; Hackett, James ; Honore, Patrick M. ; Hoste, Eric A. J. ; Joannes-Boyau, Olivier ; Joannidis, Michael ; Kim, Patrick ; Koyner, Jay L. ; Laskowitz, Daniel T. ; Lissauer, Matthew E. ; Marx, Gernot ; McCullough, Peter A. ; Mullaney, Scott ; Ostermann, Marlies ; Rimmelé, Thomas ; Shapiro, Nathan I. ; Shaw, Andrew D. ; Shi, Jing ; Sprague, Amy M. ; Vincent, Jean-Louis ; Vinsonneau, Christophe ; Wagner, Ludwig ; Walker, Michael G. ; Wilkerson, R. Gentry ; Zacharowski, Kai ; Kellum, John A.
Introduction: Acute kidney injury (AKI) can evolve quickly and clinical measures of function often fail to detect AKI at a time when interventions are likely to provide benefit. Identifying early markers of kidney damage has been difficult due to the complex nature of human AKI, in which multiple etiologies exist. The objective of this study was to identify and validate novel biomarkers of AKI.
Methods: We performed two multicenter observational studies in critically ill patients at risk for AKI - discovery and validation. The top two markers from discovery were validated in a second study (Sapphire) and compared to a number of previously described biomarkers. In the discovery phase, we enrolled 522 adults in three distinct cohorts including patients with sepsis, shock, major surgery, and trauma and examined over 300 markers. In the Sapphire validation study, we enrolled 744 adult subjects with critical illness and without evidence of AKI at enrollment; the final analysis cohort was a heterogeneous sample of 728 critically ill patients. The primary endpoint was moderate to severe AKI (KDIGO stage 2 to 3) within 12 hours of sample collection.
Results: Moderate to severe AKI occurred in 14% of Sapphire subjects. The two top biomarkers from discovery were validated. Urine insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinases-2 (TIMP-2), both inducers of G1 cell cycle arrest, a key mechanism implicated in AKI, together demonstrated an AUC of 0.80 (0.76 and 0.79 alone). Urine [TIMP-2].[IGFBP7] was significantly superior to all previously described markers of AKI (P <0.002), none of which achieved an AUC >0.72. Furthermore, [TIMP-2].[IGFBP7] significantly improved risk stratification when added to a nine-variable clinical model when analyzed using Cox proportional hazards model, generalized estimating equation, integrated discrimination improvement or net reclassification improvement. Finally, in sensitivity analyses [TIMP-2].[IGFBP7] remained significant and superior to all other markers regardless of changes in reference creatinine method.
Conclusions: Two novel markers for AKI have been identified and validated in independent multicenter cohorts. Both markers are superior to existing markers, provide additional information over clinical variables and add mechanistic insight into AKI. Trial registration: ClinicalTrials.gov number NCT01209169.
Moustakim, Moses ; Clark, Peter G. K. ; Trulli, Laura ; Fuentes de Arriba, Angel L. ; Ehebauer, Matthias T. ; Chaikuad, Apirat ; Murphy, Emma J. ; Mendez-Johnson, Jacqui ; Daniels, Danette ; Hou, Chun-Feng D. ; Lin, Yu-Hui ; Walker, John R. ; Hui, Raymond ; Yang, Hongbing ; Dorrell, Lucy ; Rogers, Catherine M. ; Monteiro, Octovia ; Fedorov, Oleg ; Huber, Kilian ; Knapp, Stefan ; Heer, Jag ; Dixon, Darren ; Brennan, Paul E.
The p300/CBP‐associated factor (PCAF) and related GCN5 bromodomain‐containing lysine acetyl transferases are members of subfamily I of the bromodomain phylogenetic tree. Iterative cycles of rational inhibitor design and biophysical characterization led to the discovery of the triazolopthalazine‐based L‐45 (dubbed L‐Moses) as the first potent, selective, and cell‐active PCAF bromodomain (Brd) inhibitor. Synthesis from readily available (1R,2S)‐(−)‐norephedrine furnished L‐45 in enantiopure form. L‐45 was shown to disrupt PCAF‐Brd histone H3.3 interaction in cells using a nanoBRET assay, and a co‐crystal structure of L‐45 with the homologous Brd PfGCN5 from Plasmodium falciparum rationalizes the high selectivity for PCAF and GCN5 bromodomains. Compound L‐45 shows no observable cytotoxicity in peripheral blood mononuclear cells (PBMC), good cell‐permeability, and metabolic stability in human and mouse liver microsomes, supporting its potential for in vivo use.
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