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Koch, Benjamin Florian ; Schult-Dietrich, Patricia ; Büttner, Stefan ; Dilmaghani, Bijan ; Lohmann, Dario ; Baer, Patrick C. ; Dietrich, Ursula ; Geiger, Helmut
Background/Aims: Middle East respiratory syndrome coronavirus (MERS-CoV) and Marburg virus (MARV) are among the World Health Organization’s top 8 emerging pathogens. Both zoonoses share nonspecific early symptoms, a high lethality rate, and a reduced number of specific treatment options. Therefore, we evaluated extracorporeal virus and glycoprotein (GP) elimination by lectin affinity plasmapheresis (LAP).
Methods: For both MERS-CoV (pseudovirus) as well as MARV (GPs), 4 LAP devices (Mini Hemopurifiers, Aethlon Medical, San Diego, CA, USA) and 4 negative controls were tested. Samples were collected every 30 min and analyzed for reduction in virus infectivity by a flow cytometry-based infectivity assay (MERS-CoV) and in soluble GP content (MARV) by an immunoassay.
Results: The experiments show a time-dependent clearance of MERS-CoV of up to 80% within 3 h (pseudovirus). Up to 70% of MARV-soluble GPs were eliminated at the same time. Substantial saturation of the binding resins was detected within the first treatment hour.
Conclusion: MERS-CoV (pseudovirus) and MARV soluble GPs are eliminated by LAP in vitro. Considering the high lethality and missing established treatment options, LAP should be evaluated in vivo. Especially early initiation, continuous therapy, and timed cartridge exchanges could be of importance.
Baer, Patrick C. ; Koch, Benjamin Florian ; Hickmann, Elena Sophie ; Schubert, Ralf ; Cinatl, Jindrich ; Hauser, Ingeborg A. ; Geiger, Helmut
Mesenchymal stromal/stem cells (MSCs) are immature multipotent cells, which represent a rare population in the perivascular niche within nearly all tissues. The most abundant source to isolate MSCs is adipose tissue. Currently, perirenal adipose tissue is rarely described as the source of MSCs. MSCs were isolated from perirenal adipose tissue (prASCs) from patients undergoing tumor nephrectomies, cultured and characterized by flow cytometry and their differentiation potential into adipocytes, chondrocytes, osteoblasts and epithelial cells. Furthermore, prASCs were stimulated with lipopolysaccharide (LPS), lipoteichoic acid (LTA) or a mixture of cytokines (cytomix). In addition, prASC susceptibility to human cytomegalovirus (HCMV) was investigated. The expression of inflammatory readouts was estimated by qPCR and immunoassay. HCMV infection was analyzed by qPCR and immunostaining. Characterization of cultured prASCs shows the cells meet the criteria of MSCs and prASCs can undergo trilineage differentiation. Cultured prASCs can be induced to differentiate into epithelial cells, shown by cytokeratin 18 expression. Stimulation of prASCs with LPS or cytomix suggests the cells are capable of initiating an inflammation-like response upon stimulation with LPS or cytokines, whereas, LTA did not induce a significant effect on the readouts (ICAM-1, IL-6, TNFα, MCP-1 mRNA and IL-6 protein). HCMV broadly infects prASCs, showing a viral load dependent cytopathological effect (CPE). Our current study summarizes the isolation and culture of prASCs, clearly characterizes the cells, and demonstrates their immunomodulatory potential and high permissiveness for HCMV
The kidneys play a vital role in the basic physiological functions of the body. Kidney dysfunction impairs these physiological functions and can lead to a wide range of diseases. Damage to the kidney cells can be caused by a variety of ischemic, toxic or immunological complaints that lead to inflammation and cell death, which can lead to organ damage and, ultimately, complete failure. Although the mechanisms underlying acute kidney injury (AKI) and chronic kidney disease (CKD) are quite distinct, clinical evidence suggests that the two conditions are inextricably interconnected [1]. AKI and CKD, regardless of the underlying cause, have inflammation and activation of the immune system as the common underlying mechanisms. Inflammation, a process aimed, in principle, at detecting and fighting harmful pathogens, is, therefore, a major pathogenic mechanism for both AKI and CKD [1]. While the kidney has the remarkable ability to regenerate after an acute injury and can recover completely, depending on the type of kidney lesion, the options for clinical interventions are currently limited to fluid management and extracorporeal kidney support. However, persistent chronic inflammation can trigger renal fibrosis and chronic kidney disease. The investigation of the molecular mechanisms involved in each individual injury is currently insufficiently understood.
Meybohm, Patrick ; Grünewald, Matthias Lars ; Albrecht, Martin ; Zacharowski, Kai ; Lucius, Ralph ; Zitta, Karina ; Koch, Alexander ; Tran, Thi Hoai Nguyen ; Scholz, Jens ; Bein, Berthold Helmut
Background: Mild therapeutic hypothermia following cardiac arrest is neuroprotective, but its effect on myocardial dysfunction that is a critical issue following resuscitation is not clear. This study sought to examine whether hypothermia and the combination of hypothermia and pharmacological postconditioning are cardioprotective in a model of cardiopulmonary resuscitation following acute myocardial ischemia. Methodology/Principal Findings: Thirty pigs (28–34 kg) were subjected to cardiac arrest following left anterior descending coronary artery ischemia. After 7 minutes of ventricular fibrillation and 2 minutes of basic life support, advanced cardiac life support was started according to the current AHA guidelines. After successful return of spontaneous circulation (n = 21), coronary perfusion was reestablished after 60 minutes of occlusion, and animals were randomized to either normothermia at 38°C, hypothermia at 33°C or hypothermia at 33°C combined with sevoflurane (each group n = 7) for 24 hours. The effects on cardiac damage especially on inflammation, apoptosis, and remodeling were studied using cellular and molecular approaches. Five animals were sham operated. Animals treated with hypothermia had lower troponin T levels (p<0.01), reduced infarct size (34±7 versus 57±12%; p<0.05) and improved left ventricular function compared to normothermia (p<0.05). Hypothermia was associated with a reduction in: (i) immune cell infiltration, (ii) apoptosis, (iii) IL-1beta and IL-6 mRNA up-regulation, and (iv) IL-1beta protein expression (p<0.05). Moreover, decreased matrix metalloproteinase-9 activity was detected in the ischemic myocardium after treatment with mild hypothermia. Sevoflurane conferred additional protective effects although statistic significance was not reached. Conclusions/Significance: Hypothermia reduced myocardial damage and dysfunction after cardiopulmonary resuscitation possible via a reduced rate of apoptosis and pro-inflammatory cytokine expression.
Aamodt, Kenneth ; Abrahantes Quintana, A. ; Adamová, Dagmar ; Adare, A.M. ; Aggarwal, Madan Mohan ; Aglieri Rinella, Gianluca ; Agocs, A.G. ; Aguilar Salazar, S. ; Ahammed, Zubayer ; Ahmad, Nazeer ; Ahmad Masoodi, A. ; Ahn, Sang Un ; Akindinov, Alexander ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alfaro Molina, Jose Ruben ; Alici, Andrea ; Alkin, Anton ; Almaráz Aviña, E. ; Alt, Torsten ; Altini, V. ; Altinpinar, Sedat ; Altsybeev, Igor ; Andrei, Cristian ; Andronic, Anton ; Anguelov, Venelin ; Anson, Christopher Daniel ; Antičić, Tome ; Antinori, Federico ; Antonioli, Pietro ; Aphecetche, Laurent Bernard ; Appelshäuser, Harald ; Arbor, N. ; Arcelli, Silvia ; Arend, A. ; Armesto, Néstor ; Arnaldi, Roberta ; Aronsson, Tomas Robert ; Arsene, Ionut Cristian ; Asryan, A. ; Augustinus, Andre ; Averbeck, Ralf Peter ; Awes, T.C. ; Äystö, J. ; Azmi, Mohd Danish ; Bach, Matthias ; Badalà, Angela ; Baek, Yong Wook ; Bagnasco, Stefano ; Bailhache, Raphaëlle ; Bala, Remu ; Baldini Ferroli, Rinaldo ; Baldisseri, Alberto ; Baldit, A. ; Bán, J. ; Barbera, Roberto ; Barile, Francesco ; Barnaföldi, Gergely Gábor ; Barnby, Lee Stuart ; Barret, Valerie ; Bartke, Jerzy ; Basile, Maurizio ; Bastid, Nicole ; Bathen, Bastian ; Batigne, Guillaume ; Batyunya, Boris ; Baumann, C. ; Bearden, Ian Gardner ; Beck, Hans ; Belikov, Iouri ; Bellini, Francesca ; Bellwied, Rene ; Belmont-Moreno, Ernesto ; Beolè, Stefania ; Berceanu, Ionela ; Bercuci, Alexandru ; Berdermann, E. ; Berdnikov, Yaroslav ; Betev, Latchezar ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bianchi, Livio ; Bianchi, Nicola ; Bianchin, Chiara ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bilandzic, Ante ; Biolcati, E. ; Blanc, A. ; Blanco, Fernando ; Blanco, Fernando ; Blau, Dmitry S. ; Blume, Christoph ; Boccioli, M. ; Bock, N. ; Bogdanov, Alexey A. ; Bøggild, Hans ; Bogolyubsky, M. ; Boldizsár, László ; Bombara, Marek ; Bombonati, C. ; Book, Julian ; Borel, Hervé ; Bortolin, C. ; Bose, S. ; Bossú, Francesco ; Botje, Michiel ; Böttger, Stefan ; Boyer, B. ; Braun-Munzinger, Peter ; Bravina, L. ; Bregant, Marco ; Breitner, Timo ; Broz, Michal ; Brun, René ; Bruna, Elena ; Bruno, Giuseppe Eugenio ; Budnikov, Dmitry ; Büsching, Henner ; Busch, Oliver ; Buthelezi, Edith Zinhle ; Caffarri, Davide ; Cai, Xiao ; Caines, Helen Louise ; Calvo Villar, Ernesto ; Camerini, Paolo ; Canoa Roman, Veronica ; Cara Romeo, G. ; Carena, Francesco ; Carena, Wisla ; Carminati, F. ; Casanova Díaz, A. ; Caselle, M. ; Castillo Castellanos, Javier Ernesto ; Catanescu, V. ; Cavicchioli, Costanza ; Cerello, Piergiorgio ; Chang, B. ; Chapeland, Sylvain ; Charvet, Jean-Luc Fernand ; Chattopadhyay, S. ; Chattopadhyay, S. ; Cherney, Michael Gerard ; Cheshkov, Cvetan Valeriev ; Cheynis, Brigitte ; Chiavassa, E. ; Chibante Barroso, Vasco Miguel ; Chinellato, David Dobrigkeit ; Chochula, Peter ; Chojnacki, Marek ; Christakoglou, Panagiotis ; Christensen, Christian Holm ; Christiansen, Peter L. ; Chujo, Tatsuya ; Cicalò, Corrado ; Cifarelli, Luisa ; Cindolo, Federico ; Cleymans, Jean Willy Andre ; Coccetti, F. ; Coffin, J.-P. ; Coli, S. ; Conesa Balbastre, Gustavo ; Conesa del Valle, Zaida ; Constantin, P. ; Contin, Giacomo ; Contreras Nuno, Jesus Guillermo ; Cormier, Thomas Michael ; Corrales Morales, Yasser ; Cortés Maldonado, Ismael ; Cortese, Pietro ; Cosentino, Mauro Rogerio ; Costa, Filippo ; Cotallo, M.E. ; Crescio, E. ; Crochet, Philippe ; Cuautle Flores, Eleazar ; Cunqueiro Mendez, Leticia ; D’Erasmo, Ginevra ; Dainese, Andrea ; Dalsgaard, H.H. ; Danu, Andrea ; Das, Debasish ; Das, Indranil ; Dash, Ajay Kumar ; Dash, Sadhana ; De, Sudipan ; De Azevedo Moregula, A. ; de Barros, G.O.V. ; De Caro, Annalisa ; De Cataldo, Giacinto ; Cuveland, Jan de ; De Falco, Alessandro ; De Gruttola, Daniele ; De Marco, Nora ; De Pasquale, Salvatore ; De Remigis, R. ; de Rooij, R. ; Delagrange, H. ; Delgado Mercado, Y. ; Dellacasa, G. ; Deloff, Andrzej ; Demanov, V. ; Dénes, Ervin Sandor ; Deppman, A. ; Di Bari, Domenico ; Di Giglio, C. ; Di Liberto, S. ; Di Mauro, Antonio ; Di Nezza, Pasquale ; Dietel, Thomas ; Divià, Roberto ; Djuvsland, Øystein ; Dobrin, Alexandru Florin ; Dobrowolski, Tadeusz Antoni ; Domínguez, I. ; Dönigus, Benjamin ; Dordic, Olja ; Driga, O. ; Dubey, Anand Kumar ; Ducroux, Laurent ; Dupieux, Pascal ; Dutta Majumdar, A.K. ; Dutta Majumdar, M.R. ; Elia, Domenico ; Emschermann, D. ; Engel, Heiko ; Erdal, H.A. ; Espagnon, Bruno ; Estienne, Magali Danielle ; Esumi, ShinIchi ; Evans, David ; Evrard, S. ; Eyyubova, Gyulnara ; Fabjan, C.W. ; Fabris, Daniela ; Faivre, Julien ; Falchieri, D. ; Fantoni, Alessandra ; Fasel, Markus ; Fearick, R. ; Fedunov, A. ; Fehlker, D. ; Fekete, V. ; Felea, Daniel ; Feofilov, Grigori A. ; Fernández Téllez, Arturo ; Ferretti, Alessandro ; Ferretti, R. ; Figueredo, Marcel Araujo Silva ; Filchagin, Sergey ; Fini, R. ; Finogeev, Dmitry ; Fionda, Fiorella Maria Celeste ; Fiore, Enrichetta Maria ; Floris, Michele ; Foertsch, Siegfried Valentin ; Foka, Panagiota ; Fokin, Sergey ; Fragiacomo, Enrico ; Fragkiadakis, M. ; Frankenfeld, Ulrich ; Fuchs, Ulrich ; Furano, F. ; Furget, Christophe ; Fusco Girard, Mario ; Gaardhøje, Jens Jørgen ; Gadrat, S. ; Gagliardi, Martino ; Gago, A. ; Gallio, Mauro ; Ganoti, Paraskevi ; Garabatos, Chilo ; Gemme, R. ; Gerhard, J. ; Germain, Marie ; Geuna, C. ; Gheata, Andrei George ; Gheata, Mihaela ; Ghidini, B. ; Ghosh, Premomoy ; Girard, M.R. ; Giraudo, G. ; Giubellino, Paolo ; Gładysz-Dziaduś, Ewa ; Glässel, Peter ; Gomez, R. ; González Trueba, Laura Helena ; González Zamora, Pedro ; González Santos, H. ; Gorbunov, Sergey ; Gotovac, Sven ; Grabski, Varlen ; Grajcarek, R. ; Gramling, J.L. ; Grelli, Alessandro ; Grigoras, Alina Gabriela ; Grigoraș, Costin ; Grigoriev, Vladislav A. ; Grigoryan, Ara ; Grigoryan, Smbat ; Grinyov, Boris V. ; Grion, Nevio ; Gros, P. ; Große-Oetringhaus, Jan Fiete ; Grossiord, Jean-Yves ; Grosso, Raffaele ; Guber, Fedor ; Guernane, Rachid ; Guerra Gutierrez, C. ; Guerzoni, Barbara ; Gulbrandsen, Kristjan Herlache ; Gulkanyan, Hrant ; Gunji, Taku ; Gupta, Anik ; Gupta, Ramni ; Gutbrod, H. ; Haaland, Øystein Senneset ; Hadjidakis, Cynthia Marie ; Haiduc, Maria ; Hamagaki, Hideki ; Hamar, Gergö ; Harris, John W. ; Hartig, M. ; Hasch, D. ; Hasegan, D. ; Hatzifotiadou, Despina ; Hayrapetyan, A. ; Heide, Markus ; Heinz, Mark Thomas ; Helstrup, Håvard ; Herghelegiu, Andrei Ionut ; Hernández, C. ; Herrera Corral, Gerardo Antonio ; Herrmann, Norbert ; Hetland, Kristin Fanebust ; Hicks, B. ; Hille, P.T. ; Hippolyte, Boris ; Horaguchi, T. ; Hori, Y. ; Hristov, Peter ; Hřivnáčová, I. ; Huang, M. ; Huber, S. ; Humanic, Thomas J. ; Hwang, D.S. ; Ichou, R. ; Ilkaev, Radiy ; Ilkiv, Iryna ; Inaba, Motoi ; Incani, E. ; Innocenti, Gian Michele ; Innocenti, P.G. ; Ippolitov, Mikhail ; Irfan, M. ; Ivan, C. ; Ivanov, A. ; Ivanov, Marian ; Ivanov, V. ; Jacholkowski, Adam Wlodzimierz ; Jacobs, Peter Martin ; Jancurová, L. ; Jangal, S. ; Janik, R. ; Jayarathna, S.P. ; Jena, Satyajit ; Jirden, L. ; Jones, Goronwy Tudor ; Jones, Peter Graham ; Jovanović, P. ; Jung, H. ; Jung, W. ; Jusko, Anton ; Kalcher, S. ; Kaliňák, Peter ; Kalisky, M. ; Kalliokoski, T. ; Kalweit, Alexander Philipp ; Kamermans, R. ; Kanaki, K. ; Kang, E. ; Kang, Ju Hwan ; Kaplin, Vladimir ; Karavichev, Oleg V. ; Karavicheva, Tatiana L. ; Karpechev, Evgeny ; Kazantsev, Andrey ; Kebschull, Udo ; Keidel, Ralf ; Khan, M.M. ; Khanzadeev, Alexei ; Kharlov, Yury ; Kileng, Bjarte ; Kim, D.J. ; Kim, D.S. ; Kim, D.W. ; Kim, H.N. ; Kim, J.H. ; Kim, J.S. ; Kim, M. ; Kim, M. ; Kim, S. ; Kim, S.H. ; Kirsch, Stefan ; Kisel, Ivan ; Kiselev, Sergej N. ; Kisiel, Adam Ryszard ; Klay, Jennifer Lynn ; Klein, Jochen ; Klein-Bösing, Christian ; Kliemant, Michael ; Klovning, A. ; Kluge, Alexander ; Knichel, Michael Linus ; Koch, K. ; Köhler, Markus Konrad ; Kolevatov, R. ; Kolojvari, Anatoly ; Kondratiev, Valery P. ; Kondratyeva, Natalia ; Konevskih, A. ; Kornaś, Ewelina ; Kottachchi Kankanamge Don, C. ; Kour, R. ; Kowalski, Marek ; Kox, Serge ; Koyithatta Meethaleveedu, Greeshma ; Kozlov, K. ; Kral, Jiří ; Králik, Ivan ; Kramer, F. ; Kraus, Ingrid ; Krawutschke, T. ; Kretz, Matthias ; Krivda, Marian ; Krumbhorn, D. ; Krus, M. ; Kryshen, Evgeny ; Krzewicki, Mikolaj ; Kucheriaev, Yury ; Kuhn, Christian Claude ; Kuijer, Paulus Gerardus ; Kurashvili, Podist ; Kurepin, Alexander ; Kurepin, Alexey B. ; Kuryakin, Alexey ; Kushpil, Svetlana ; Kushpil, V. ; Kweon, Min Jung ; Kwon, Youngil ; La Rocca, Paola ; Ladron de Guevara, Pedro ; Lafage, V. ; Lara Martinez, Camilo Ernesto ; Larsen, D.T. ; Lazzeroni, C. ; Le Bornec, Y. ; Lea, Ramona ; Lee, K.S. ; Lee, S.C. ; Lefèvre, F. ; Lehnert, Jörg ; Leistam, L. ; Lenhardt, M. ; Lenti, Vito ; León Monzón, Ildefonso ; León Vargas, H. ; Lévai, Péter ; Li, X. ; Lietava, Roman ; Lindal, Svein ; Lindenstruth, Volker ; Lippmann, Christian ; Lisa, Michael A. ; Liu, L. ; Loggins, Vera Renee ; Loginov, Vitaly ; Lohn, S. ; Lohner, D. ; Loizides, Constantinos ; Lopez, Xavier Bernard ; López Noriega, M. ; López Torres, Ernesto ; Løvhøiden, G. ; Lu, X.-G. ; Lüttig, Philipp ; Lunardon, Marcello ; Luparello, Grazia ; Luquin, L. ; Luzzi, C. ; Ma, K. ; Ma, R. ; Madagodahettige-Don, D.M. ; Maevskaya, Alla ; Mager, Magnus ; Mahapatra, D.P. ; Maire, Antonin ; Malaev, Mikhail ; Maldonado Cervantes, Ivonne Alicia ; Malinina, Liudmila ; Mal’Kevich, Dmitry ; Malzacher, Peter ; Mamonov, Alexander ; Manceau, Loic Henri Antoine ; Mangotra, L. ; Manko, Vladislav ; Manso, Franck ; Manzari, Vito ; Mao, Yaxian ; Mareš, Jiří ; Margagliotti, Giacomo Vito ; Margotti, Anselmo ; Marín, Ana ; Martashvili, Irakli ; Martinengo, Paolo ; Martínez Hernández, Mario Iván ; Martínez Davalos, A. ; Martínez Garcia, Ginés ; Martynov, Yevgen ; Mas, Alexis Jean-Michel ; Masciocchi, Silvia ; Masera, Massimo ; Masoni, Alberto ; Massacrier, Laure Marie ; Mastromarco, Mario ; Mastroserio, Annalisa ; Matthews, Z.L. ; Matyja, Adam Tomasz ; Mayani, D. ; Mazza, G. ; Mazzoni, Alessandra Maria ; Meddi, Franco ; Menchaca-Rocha, Arturo Alejandro ; Mendez Lorenzo, P. ; Mercado Pérez, Jorge ; Mereu, P. ; Miake, Yasuo ; Midori, J. ; Milano, Leonardo ; Milošević, Jovan ; Mischke, André ; Miśkowiec, Dariusz Czesław ; Mitu, C. ; Mlynarz, J. ; Mohanty, Bedangadas ; Molnar, Levente ; Montaño Zetina, Luis Manuel ; Monteno, M. ; Montes Prado, Esther ; Morando, Maurizio ; Godoy, Denise Aparecida Moreira de ; Moretto, Sandra ; Morsch, Andreas ; Muccifora, Valeria ; Mudnic, Eugen ; Müller, H. ; Muhuri, Sanjib ; Munhoz, Marcelo Gameiro ; Munoz, J. ; Musa, Luciano ; Musso, A. ; Nandi, Basanta Kumar ; Nania, Rosario ; Nappi, Eugenio ; Nattrass, Christine ; Navach, F. ; Navin, S. ; Nayak, Tapan Kumar ; Nazarenko, Sergey ; Nazarov, G. ; Nedosekin, Alexander ; Nendaz, F. ; Newby, J. ; Nicassio, Maria ; Nielsen, Borge Svane ; Nikolaev, Sergey ; Nikolic, V. ; Nikulin, Sergey ; Nikulin, Vladimir ; Nilsen, B.S. ; Nilsson, M.S. ; Noferini, Francesco ; Nooren, Gerardus ; Novitzky, Norbert ; Nyanin, Alexander ; Nyatha, A. ; Nygaard, C. ; Nystrand, Joakim Ingemar ; Obayashi, H. ; Ochirov, A. ; Oeschler, Helmut ; Oh, Sun Kun ; Oleniacz, Janusz ; Oppedisano, Chiara ; Ortiz Velasquez, Antonio ; Ortona, G. ; Oskarsson, Anders Nils Erik ; Ostrowski, P. ; Otterlund, I. ; Otwinowski, Jacek Tomasz ; Ø, G. ; Oyama, Ken ; Ozawa, K. ; Pachmayer, Yvonne C. ; Pachr, Miloš ; Padilla, F. ; Pagano, Paola ; Paić, Guy ; Painke, F. ; Pajares Vales, Carlos ; Pal, S. ; Pal, Susanta Kumar ; Palaha, A. ; Palmeri, A. ; Pappalardo, Giuseppe Salvatore ; Park, WooJin ; Paticchio, Vincenzo ; Pavlinov, A. ; Pawlak, Tomasz Jan ; Peitzmann, Thomas ; Peresunko, Dmitry Yurevich ; Pérez Lara, Carlos Eugenio ; Perini, D. ; Perrino, D. ; Peryt, Wiktor Stanislaw ; Pesci, A. ; Peskov, Vladimir ; Pestov, Yury N. ; Peters, A.J. ; Petráček, Vojtech ; Petris, M. ; Petrov, P. ; Petrovici, Mihai A. ; Petta, Catia ; Piano, Stefano ; Piccotti, A. ; Pikna, Miroslav ; Pillot, Philippe ; Pinazza, Ombretta ; Pinsky, Lawrence ; Pitz, N. ; Piuz, F. ; Piyarathna, Danthasinghe B. ; Platt, R. ; Płoskoń, Mateusz ; Pluta, Jan Marian ; Pocheptsov, T. ; Pochybova, Sona ; Podesta Lerma, Pedro Luis Manuel ; Poghosyan, Martin G. ; Polák, K. ; Polichtchouk, Boris ; Pop, Amalia ; Pospíšil, V. ; Potukuchi, B. ; Prasad, Sidharth Kumar ; Preghenella, Roberto ; Prino, Francesco ; Pruneau, Claude A. ; Pshenichnov, Igor A. ; Puddu, Giovanna ; Pulvirenti, A. ; Punin, Valery ; Putiš, M. ; Putschke, Jörn H. ; Quercigh, E. ; Qvigstad, Henrik ; Rachevski, Alexandre ; Rademakers, A. ; Rademakers, O. ; Radomski, S. ; Räihä, T.S. ; Rak, Jan ; Rakotozafindrabe, Andry Malala ; Ramello, Luciano ; Ramírez Reyes, A. ; Rammler, M. ; Raniwala, Rashmi ; Raniwala, Sudhir ; Räsänen, Sami Sakari ; Read, Kenneth Francis ; Real, Jean-Sébastien ; Redlich, Krzysztof ; Renfordt, Rainer Arno Ernst ; Reolon, Anna Rita ; Reshetin, Andrey ; Rettig, Felix Vincenz ; Revol, Jean-Pierre ; Reygers, Klaus ; Ricaud, H. ; Riccati, L. ; Ricci, Renato Angelo ; Richter, Matthias Rudolph ; Riedler, Petra ; Riegler, Werner ; Riggi, Francesco ; Rivetti, Angelo ; Rodrı́guez Cahuantzi, Mario ; Rohr, David ; Röhrich, Dieter ; Romita, Rosa ; Ronchetti, Federico ; Rosinský, P. ; Rosnet, Philippe ; Rossegger, S. ; Rossi, Andrea ; Roukoutakis, Filimon ; Rousseau, S. ; Roy, Christelle Sophie ; Roy, Pradip Kumar ; Rubio Montero, Antonio Juan ; Rui, Rinaldo ; Rusanov, I. ; Ryabinkin, Evgeny ; Rybicki, Andrzej ; Sadovskiy, Sergey ; Šafařík, Karel ; Sahoo, Raghunath ; Sahu, Pradip Kumar ; Saiz, P. ; Sakai, Shingo ; Sakata, D. ; Salgado, Carlos A. ; Samanta, T. ; Sambyal, Sanjeev Singh ; Samsonov, Vladimir ; Šándor, Ladislav ; Sandoval, Andres ; Sano, Masato ; Sano, S. ; Santo, R. ; Santoro, R. ; Sarkamo, J. ; Saturnini, P. ; Scapparone, Eugenio ; Scarlassara, Fernando ; Scharenberg, Rolf Paul ; Schiaua, Claudiu Cornel ; Schicker, Rainer ; Schmidt, Christian Joachim ; Schmidt, Hans Rudolf ; Schreiner, S. ; Schuchmann, Simone ; Schukraft, Jürgen ; Schutz, Yves Roland ; Schwarz, Kilian ; Schweda, Kai ; Scioli, Gilda ; Scomparin, Enrico ; Scott, P.A. ; Scott, Rebecca Michelle ; Segato, G. ; Senyukov, Serhiy ; Seo, Jeewon ; Serci, S. ; Serradilla, Eulogio ; Sevcenco, Adrian ; Shabratova, G. ; Shahoyan, Ruben ; Sharma, Natasha ; Sharma, S. ; Shigaki, Kenta ; Shimomura, Maya ; Shtejer, Katherin ; Sibiriak, Yury ; Siciliano, M. ; Sicking, E. ; Siemiarczuk, Teodor ; Silenzi, A. ; Silvermyr, David Olle Rickard ; Simonetti, Giuseppe ; Singaraju, Rama Narayana ; Singh, R. ; Sinha, Bikash ; Sinha, Tinku ; Sitar, Branislav ; Sitta, Mario ; Skaali, Toralf Bernhard ; Skjerdal, K. ; Smakal, R. ; Smirnov, N. ; Snellings, Raimond ; Søgaard, C. ; Soloviev, A. ; Soltz, Ron ; Son, H. ; Song, M. ; Soos, C. ; Soramel, Francesca ; Spyropoulou-Stassinaki, Martha ; Srivastava, Brijesh Kumar ; Stachel, Johanna ; Stan, Ionel ; Stefanek, Grzegorz ; Stefanini, G. ; Steinbeck, T. ; Stenlund, Evert Anders ; Steyn, Gideon Francois ; Stocco, Diego ; Stock, Reinhard ; Stolpovskiy, M. ; Strmen, Peter ; Suaide, Alexandre Alarcon do Passo ; Subieta Vasquez, Martin Alfonso ; Sugitate, Toru ; Suire, Christophe Pierre ; Šumbera, Michal ; Šuša, Tatjana ; Swoboda, D. ; Symons, Timothy James MacNeil ; Toledo, Alejandro Szanto de ; Szarka, Imrich ; Szostak, A. ; Tagridis, C. ; Takahashi, Jun ; Tapia Takaki, Jesus Daniel ; Tauro, Arturo ; Tavlet, M. ; Tejeda Muñoz, Guillermo ; Telesca, Adriana ; Terrevoli, Cristina ; Thäder, Jochen ; Thomas, Deepa ; Thomas, James H. ; Tieulent, Raphael Noel ; Timmins, Anthony Robert ; Tlusty, David ; Toia, Alberica ; Torii, H. ; Toscano, L. ; Tosello, F. ; Traczyk, T. ; Truesdale, David Christopher ; Trzaska, Wladyslaw Henryk ; Tumkin, Alexandr ; Turrisi, Rosario ; Turvey, A.J. ; Tveter, Trine Spedstad ; Ulery, Jason Glyndwr ; Ullaland, Kjetil ; Uras, Antonio ; Urbán, J. ; Urciuoli, G.M. ; Usai, Gianluca ; Vacchi, A. ; Vala, Martin ; Valencia Palomo, Lizardo ; Vallero, Sara ; Kolk, Naomi van der ; Leeuwen, Marco van ; Vyvre, Pierre vande ; Vannucci, L. ; Vargas Treviño, Maria Aurora Diozcora ; Varma, Raghava ; Vasileiou, Maria ; Vasiliev, Andrey ; Vechernin, Vladimir ; Venaruzzo, Massimo ; Vercellin, Ermanno ; Vergara, S. ; Vernet, Renaud ; Verweij, Marta ; Vicković, Linda ; Viesti, Giuseppe ; Vikhlyantsev, O. ; Vilakazi, Zabulon ; Villalobos Baillie, Orlando ; Vinogradov, Alexander A. ; Vinogradov, Leonid ; Vinogradov, Yury I. ; Virgili, Tiziano ; Viyogi, Yogendra P. ; Vodopyanov, Alexander ; Voloshin, Kirill ; Voloshin, Sergei ; Volpe, Giacomo ; Haller, Barthélémy von ; Vranić, Danilo ; Vrláková, Janka ; Vulpescu, Bogdan ; Wagner, Boris ; Wagner, V. ; Wan, R. ; Wang, D. ; Wang, Y. ; Wang, Y. ; Watanabe, K. ; Wessels, Johannes P. ; Westerhoff, Uwe ; Wiechula, Jens ; Wikne, Jon ; Wilde, Martin ; Wilk, A. ; Wilk, Grzegorz Andrzej ; Williams, M. Crispin S. ; Windelband, Bernd ; Yang, H. ; Yasnopolskiy, S. ; Yi, J. ; Yin, Zhongbao ; Yokoyama, Hiroki ; Yoo, In-Kwon ; Yuan, X. ; Yushmanov, Igor E. ; Zabrodin, E. ; Zampolli, Chiara ; Zaporozhets, Sergey ; Zarochentsev, Andrey ; Závada, Petr ; Zbroszczyk, Hanna Paulina ; Zelnicek, P. ; Zenin, A. ; Zgura, I. ; Zhalov, Mikhail ; Zhang, X. ; Zhou, D. ; Zhu, X. ; Zichichi, Antonino ; Zinovjev, Gennady M. ; Zoccarato, Y. ; Zynovyev, M.
The first measurement of two-pion Bose–Einstein correlations in central Pb–Pb collisions at √sNN=2.76 TeV at the Large Hadron Collider is presented. We observe a growing trend with energy now not only for the longitudinal and the outward but also for the sideward pion source radius. The pion homogeneity volume and the decoupling time are significantly larger than those measured at RHIC.
Aamodt, Kenneth ; Abrahantes Quintana, A. ; Adamová, Dagmar ; Adare, A.M. ; Aggarwal, Madan Mohan ; Aglieri Rinella, Gianluca ; Agocs, A.G. ; Aguilar Salazar, S. ; Ahammed, Zubayer ; Ahmad, Nazeer ; Ahmad Masoodi, A. ; Ahn, Sang Un ; Akindinov, Alexander ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alfaro Molina, Jose Ruben ; Alici, Andrea ; Alkin, Anton ; Almaráz Aviña, E. ; Alt, Torsten ; Altini, V. ; Altinpinar, Sedat ; Altsybeev, Igor ; Andrei, Cristian ; Andronic, Anton ; Anguelov, Venelin ; Anson, Christopher Daniel ; Antičić, Tome ; Antinori, Federico ; Antonioli, Pietro ; Aphecetche, Laurent Bernard ; Appelshäuser, Harald ; Arbor, N. ; Arcelli, Silvia ; Arend, A. ; Armesto, Néstor ; Arnaldi, Roberta ; Aronsson, Tomas Robert ; Arsene, Ionut Cristian ; Asryan, A. ; Augustinus, Andre ; Averbeck, Ralf Peter ; Awes, T.C. ; Äystö, J. ; Azmi, Mohd Danish ; Bach, Matthias ; Badalà, Angela ; Baek, Yong Wook ; Bagnasco, Stefano ; Bailhache, Raphaëlle ; Bala, Remu ; Baldini Ferroli, Rinaldo ; Baldisseri, Alberto ; Baldit, A. ; Bán, J. ; Barbera, Roberto ; Barile, Francesco ; Barnaföldi, Gergely Gábor ; Barnby, Lee Stuart ; Barret, Valerie ; Bartke, Jerzy ; Basile, Maurizio ; Bastid, Nicole ; Bathen, Bastian ; Batigne, Guillaume ; Batyunya, Boris ; Baumann, C. ; Bearden, Ian Gardner ; Beck, Hans ; Belikov, Iouri ; Bellini, Francesca ; Bellwied, Rene ; Belmont-Moreno, Ernesto ; Beolè, Stefania ; Berceanu, Ionela ; Bercuci, Alexandru ; Berdermann, E. ; Berdnikov, Yaroslav ; Betev, Latchezar ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bianchi, Livio ; Bianchi, Nicola ; Bianchin, Chiara ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bilandzic, Ante ; Biolcati, E. ; Blanc, A. ; Blanco, Fernando ; Blanco, Fernando ; Blau, Dmitry S. ; Blume, Christoph ; Boccioli, M. ; Bock, N. ; Bogdanov, Alexey A. ; Bøggild, Hans ; Bogolyubsky, M. ; Boldizsár, László ; Bombara, Marek ; Bombonati, C. ; Book, Julian ; Borel, Hervé ; Bortolin, C. ; Bose, S. ; Bossú, Francesco ; Botje, Michiel ; Böttger, Stefan ; Boyer, B. ; Braun-Munzinger, Peter ; Bravina, L. ; Bregant, Marco ; Breitner, Timo ; Broz, Michal ; Brun, René ; Bruna, Elena ; Bruno, Giuseppe Eugenio ; Budnikov, Dmitry ; Büsching, Henner ; Busch, Oliver ; Buthelezi, Edith Zinhle ; Caffarri, Davide ; Cai, Xiao ; Caines, Helen Louise ; Calvo Villar, Ernesto ; Camerini, Paolo ; Canoa Roman, Veronica ; Cara Romeo, G. ; Carena, Francesco ; Carena, Wisla ; Carminati, F. ; Casanova Díaz, A. ; Caselle, M. ; Castillo Castellanos, Javier Ernesto ; Catanescu, V. ; Cavicchioli, Costanza ; Cerello, Piergiorgio ; Chang, B. ; Chapeland, Sylvain ; Charvet, Jean-Luc Fernand ; Chattopadhyay, S. ; Chattopadhyay, S. ; Cherney, Michael Gerard ; Cheshkov, Cvetan Valeriev ; Cheynis, Brigitte ; Chiavassa, E. ; Chibante Barroso, Vasco Miguel ; Chinellato, David Dobrigkeit ; Chochula, Peter ; Chojnacki, Marek ; Christakoglou, Panagiotis ; Christensen, Christian Holm ; Christiansen, Peter L. ; Chujo, Tatsuya ; Cicalò, Corrado ; Cifarelli, Luisa ; Cindolo, Federico ; Cleymans, Jean Willy Andre ; Coccetti, F. ; Coffin, J.-P. ; Coli, S. ; Conesa Balbastre, Gustavo ; Conesa del Valle, Zaida ; Constantin, P. ; Contin, Giacomo ; Contreras Nuno, Jesus Guillermo ; Cormier, Thomas Michael ; Corrales Morales, Yasser ; Cortés Maldonado, Ismael ; Cortese, Pietro ; Cosentino, Mauro Rogerio ; Costa, Filippo ; Cotallo, M.E. ; Crescio, E. ; Crochet, Philippe ; Cuautle Flores, Eleazar ; Cunqueiro Mendez, Leticia ; Erasmo, G.D. ; Dainese, Andrea ; Dalsgaard, H.H. ; Danu, Andrea ; Das, Debasish ; Das, Indranil ; Dash, Ajay Kumar ; Dash, Sadhana ; De, Sudipan ; De Azevedo Moregula, A. ; de Barros, G.O.V. ; De Caro, Annalisa ; De Cataldo, Giacinto ; Cuveland, Jan de ; De Falco, Alessandro ; De Gruttola, Daniele ; De Marco, Nora ; De Pasquale, Salvatore ; De Remigis, R. ; de Rooij, R. ; Delagrange, H. ; Delgado Mercado, Y. ; Dellacasa, G. ; Deloff, Andrzej ; Demanov, V. ; Dénes, Ervin Sandor ; Deppman, A. ; Di Bari, Domenico ; Di Giglio, C. ; Di Liberto, S. ; Di Mauro, Antonio ; Di Nezza, Pasquale ; Dietel, Thomas ; Divià, Roberto ; Djuvsland, Øystein ; Dobrin, Alexandru Florin ; Dobrowolski, Tadeusz Antoni ; Domínguez, I. ; Dönigus, Benjamin ; Dordic, Olja ; Driga, O. ; Dubey, Anand Kumar ; Dubuisson, J. ; Ducroux, Laurent ; Dupieux, Pascal ; Dutta Majumdar, A.K. ; Dutta Majumdar, M.R. ; Elia, Domenico ; Emschermann, D. ; Engel, Heiko ; Erdal, H.A. ; Espagnon, Bruno ; Estienne, Magali Danielle ; Esumi, ShinIchi ; Evans, David ; Evrard, S. ; Eyyubova, Gyulnara ; Fabjan, C.W. ; Fabris, Daniela ; Faivre, Julien ; Falchieri, D. ; Fantoni, Alessandra ; Fasel, Markus ; Fearick, R. ; Fedunov, A. ; Fehlker, D. ; Fekete, V. ; Felea, Daniel ; Feofilov, Grigori A. ; Fernández Téllez, Arturo ; Ferretti, Alessandro ; Ferretti, R. ; Figueredo, Marcel Araujo Silva ; Filchagin, Sergey ; Fini, R. ; Finogeev, Dmitry ; Fionda, Fiorella Maria Celeste ; Fiore, Enrichetta Maria ; Floris, Michele ; Foertsch, Siegfried Valentin ; Foka, Panagiota ; Fokin, Sergey ; Fragiacomo, Enrico ; Fragkiadakis, M. ; Frankenfeld, Ulrich ; Fuchs, Ulrich ; Furano, F. ; Furget, Christophe ; Fusco Girard, Mario ; Gaardhøje, Jens Jørgen ; Gadrat, S. ; Gagliardi, Martino ; Gago, A. ; Gallio, Mauro ; Ganoti, Paraskevi ; Garabatos, Chilo ; Gemme, R. ; Gerhard, J. ; Germain, Marie ; Geuna, C. ; Gheata, Andrei George ; Gheata, Mihaela ; Ghidini, B. ; Ghosh, Premomoy ; Girard, M.R. ; Giraudo, G. ; Giubellino, Paolo ; Gładysz-Dziaduś, Ewa ; Glässel, Peter ; Gomez, R. ; González Trueba, Laura Helena ; González Zamora, Pedro ; González Santos, H. ; Gorbunov, Sergey ; Gotovac, Sven ; Grabski, Varlen ; Grajcarek, R. ; Grelli, Alessandro ; Grigoras, Alina Gabriela ; Grigoraș, Costin ; Grigoriev, Vladislav A. ; Grigoryan, Ara ; Grigoryan, Smbat ; Grinyov, Boris V. ; Grion, Nevio ; Gros, P. ; Große-Oetringhaus, Jan Fiete ; Grossiord, Jean-Yves ; Grosso, Raffaele ; Guber, Fedor ; Guernane, Rachid ; Guerra Gutierrez, C. ; Guerzoni, Barbara ; Gulbrandsen, Kristjan Herlache ; Gunji, Taku ; Gupta, Anik ; Gupta, Ramni ; Gutbrod, H. ; Haaland, Øystein Senneset ; Hadjidakis, Cynthia Marie ; Haiduc, Maria ; Hamagaki, Hideki ; Hamar, Gergö ; Harris, John W. ; Hartig, M. ; Hasch, D. ; Hasegan, D. ; Hatzifotiadou, Despina ; Hayrapetyan, A. ; Heide, Markus ; Heinz, Mark Thomas ; Helstrup, Håvard ; Herghelegiu, Andrei Ionut ; Hernández, C. ; Herrera Corral, Gerardo Antonio ; Herrmann, Norbert ; Hetland, Kristin Fanebust ; Hicks, B. ; Hille, P.T. ; Hippolyte, Boris ; Horaguchi, T. ; Hori, Y. ; Hristov, Peter ; Hřivnáčová, I. ; Huang, M. ; Huber, S. ; Humanic, Thomas J. ; Hwang, D.S. ; Ichou, R. ; Ilkaev, Radiy ; Ilkiv, Iryna ; Inaba, Motoi ; Incani, E. ; Innocenti, Gian Michele ; Innocenti, P.G. ; Ippolitov, Mikhail ; Irfan, M. ; Ivan, C. ; Ivanov, A. ; Ivanov, Marian ; Ivanov, V. ; Jacholkowski, Adam Wlodzimierz ; Jacobs, Peter Martin ; Jancurová, L. ; Jangal, S. ; Janik, R. ; Jayarathna, S.P. ; Jena, Satyajit ; Jirden, L. ; Jones, Goronwy Tudor ; Jones, Peter Graham ; Jovanović, P. ; Jung, H. ; Jung, W. ; Jusko, Anton ; Kalcher, S. ; Kaliňák, Peter ; Kalisky, M. ; Kalliokoski, T. ; Kalweit, Alexander Philipp ; Kamermans, R. ; Kanaki, K. ; Kang, E. ; Kang, Ju Hwan ; Kaplin, Vladimir ; Karavichev, Oleg V. ; Karavicheva, Tatiana L. ; Karpechev, Evgeny ; Kazantsev, Andrey ; Kebschull, Udo ; Keidel, Ralf ; Khan, M.M. ; Khanzadeev, Alexei ; Kharlov, Yury ; Kileng, Bjarte ; Kim, D.J. ; Kim, D.S. ; Kim, D.W. ; Kim, H.N. ; Kim, J.H. ; Kim, J.S. ; Kim, M. ; Kim, M. ; Kim, S. ; Kim, S.H. ; Kirsch, Stefan ; Kisel, Ivan ; Kiselev, Sergej N. ; Kisiel, Adam Ryszard ; Klay, Jennifer Lynn ; Klein, Jochen ; Klein-Bösing, Christian ; Kliemant, Michael ; Klovning, A. ; Kluge, Alexander ; Knichel, Michael Linus ; Koch, K. ; Köhler, Markus Konrad ; Kolevatov, R. ; Kolojvari, Anatoly ; Kondratiev, Valery P. ; Kondratyeva, Natalia ; Konevskih, A. ; Kornaś, Ewelina ; Kottachchi Kankanamge Don, C. ; Kour, R. ; Kowalski, Marek ; Kox, Serge ; Kozlov, K. ; Kral, Jiří ; Králik, Ivan ; Kramer, F. ; Kraus, Ingrid ; Krawutschke, T. ; Kretz, Matthias ; Krivda, Marian ; Krumbhorn, D. ; Krus, M. ; Kryshen, Evgeny ; Krzewicki, Mikolaj ; Kucheriaev, Yury ; Kuhn, Christian Claude ; Kuijer, Paulus Gerardus ; Kurashvili, Podist ; Kurepin, Alexander ; Kurepin, Alexey B. ; Kuryakin, Alexey ; Kushpil, Svetlana ; Kushpil, V. ; Kweon, Min Jung ; Kwon, Youngil ; La Rocca, Paola ; Ladron de Guevara, Pedro ; Lafage, V. ; Lara Martinez, Camilo Ernesto ; Larsen, D.T. ; Lazzeroni, C. ; Le Bornec, Y. ; Lea, Ramona ; Lee, K.S. ; Lee, S.C. ; Lefèvre, F. ; Lehnert, Jörg ; Leistam, L. ; Lenhardt, M. ; Lenti, Vito ; León Monzón, Ildefonso ; León Vargas, H. ; Lévai, Péter ; Li, X. ; Lietava, Roman ; Lindal, Svein ; Lindenstruth, Volker ; Lippmann, Christian ; Lisa, Michael A. ; Liu, L. ; Loggins, Vera Renee ; Loginov, Vitaly ; Lohn, S. ; Lohner, D. ; Loizides, Constantinos ; Lopez, Xavier Bernard ; López Noriega, M. ; López Torres, Ernesto ; Løvhøiden, G. ; Lu, X.-G. ; Lüttig, Philipp ; Lunardon, Marcello ; Luparello, Grazia ; Luquin, L. ; Luzzi, C. ; Ma, K. ; Ma, R. ; Madagodahettige-Don, D.M. ; Maevskaya, Alla ; Mager, Magnus ; Mahapatra, D.P. ; Maire, Antonin ; Malaev, Mikhail ; Maldonado Cervantes, Ivonne Alicia ; Mal’Kevich, Dmitry ; Malzacher, Peter ; Mamonov, Alexander ; Manceau, Loic Henri Antoine ; Mangotra, L. ; Manko, Vladislav ; Manso, Franck ; Manzari, Vito ; Mao, Yaxian ; Mareš, Jiří ; Margagliotti, Giacomo Vito ; Margotti, Anselmo ; Marín, Ana ; Martashvili, Irakli ; Martinengo, Paolo ; Martínez Hernández, Mario Iván ; Martínez Davalos, A. ; Martínez Garcia, Ginés ; Martynov, Yevgen ; Mas, Alexis Jean-Michel ; Masciocchi, Silvia ; Masera, Massimo ; Masoni, Alberto ; Massacrier, Laure Marie ; Mastromarco, Mario ; Mastroserio, Annalisa ; Matthews, Z.L. ; Matyja, Adam Tomasz ; Mayani, D. ; Mazza, G. ; Mazzoni, Alessandra Maria ; Meddi, Franco ; Menchaca-Rocha, Arturo Alejandro ; Mendez Lorenzo, P. ; Mercado Pérez, Jorge ; Mereu, P. ; Miake, Yasuo ; Midori, J. ; Milano, Leonardo ; Milošević, Jovan ; Mischke, André ; Miśkowiec, Dariusz Czesław ; Mitu, C. ; Mlynarz, J. ; Mohanty, Bedangadas ; Molnar, Levente ; Montaño Zetina, Luis Manuel ; Monteno, M. ; Montes Prado, Esther ; Morando, Maurizio ; Godoy, Denise Aparecida Moreira de ; Moretto, Sandra ; Morsch, Andreas ; Muccifora, Valeria ; Mudnic, Eugen ; Müller, H. ; Muhuri, Sanjib ; Munhoz, Marcelo Gameiro ; Munoz, J. ; Musa, Luciano ; Musso, A. ; Nandi, Basanta Kumar ; Nania, Rosario ; Nappi, Eugenio ; Nattrass, Christine ; Navach, F. ; Navin, S. ; Nayak, Tapan Kumar ; Nazarenko, Sergey ; Nazarov, G. ; Nedosekin, Alexander ; Nendaz, F. ; Newby, J. ; Nicassio, Maria ; Nielsen, Borge Svane ; Nikolaev, Sergey ; Nikolic, V. ; Nikulin, Sergey ; Nikulin, Vladimir ; Nilsen, B.S. ; Nilsson, M.S. ; Noferini, Francesco ; Nooren, Gerardus ; Novitzky, Norbert ; Nyanin, Alexander ; Nyatha, A. ; Nygaard, C. ; Nystrand, Joakim Ingemar ; Obayashi, H. ; Ochirov, A. ; Oeschler, Helmut ; Oh, Sun Kun ; Oleniacz, Janusz ; Oppedisano, Chiara ; Ortiz Velasquez, Antonio ; 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Inclusive transverse momentum spectra of primary charged particles in Pb–Pb collisions at √sNN=2.76 TeV have been measured by the ALICE Collaboration at the LHC. The data are presented for central and peripheral collisions, corresponding to 0–5% and 70–80% of the hadronic Pb–Pb cross section. The measured charged particle spectra in |η|<0.8 and 0.3<pT<20 GeV/c are compared to the expectation in pp collisions at the same sNN, scaled by the number of underlying nucleon–nucleon collisions. The comparison is expressed in terms of the nuclear modification factor RAA. The result indicates only weak medium effects (RAA≈0.7) in peripheral collisions. In central collisions, RAA reaches a minimum of about 0.14 at pT=6–7 GeV/c and increases significantly at larger pT. The measured suppression of high-pT particles is stronger than that observed at lower collision energies, indicating that a very dense medium is formed in central Pb–Pb collisions at the LHC.
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The inclusive charged particle transverse momentum distribution is measured in proton–proton collisions at s=900 GeV at the LHC using the ALICE detector. The measurement is performed in the central pseudorapidity region (|η|<0.8) over the transverse momentum range 0.15<pT<10 GeV/c. The correlation between transverse momentum and particle multiplicity is also studied. Results are presented for inelastic (INEL) and non-single-diffractive (NSD) events. The average transverse momentum for |η|<0.8 is 〈pT〉INEL=0.483±0.001 (stat.)±0.007 (syst.) GeV/c and 〈pT〉NSD=0.489±0.001 (stat.)±0.007 (syst.) GeV/c, respectively. The data exhibit a slightly larger 〈pT〉 than measurements in wider pseudorapidity intervals. The results are compared to simulations with the Monte Carlo event generators PYTHIA and PHOJET.
Rapidity and transverse momentum dependence of inclusive J/ψ production in pp collisions at √s=7 TeV
(2011)
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The ALICE experiment at the LHC has studied inclusive J/ψ production at central and forward rapidities in pp collisions at √s=7 TeV. In this Letter, we report on the first results obtained detecting the J/ψ through the dilepton decay into e+e− and μ+μ− pairs in the rapidity ranges |y|<0.9 and 2.5<y<4, respectively, and with acceptance down to zero pT. In the dielectron channel the analysis was carried out on a data sample corresponding to an integrated luminosity Lint=5.6 nb−1 and the number of signal events is NJ/ψ=352±32(stat.)±28(syst.); the corresponding figures in the dimuon channel are Lint=15.6 nb−1 and NJ/ψ=1924±77(stat.)±144(syst.). The measured production cross sections are σJ/ψ(|y|<0.9)=10.7±1.0(stat.)±1.6(syst.)−2.3+1.6(syst.pol.)μb and σJ/ψ(2.5<y<4)=6.31±0.25(stat.)±0.76(syst.)−1.96+0.95(syst.pol.)μb. The differential cross sections, in transverse momentum and rapidity, of the J/ψ were also measured.
Baer, Patrick C. ; Overath, Jürgen M. ; Urbschat, Anja ; Schubert, Ralf ; Koch, Benjamin Florian ; Bohn, Asanke A. ; Geiger, Helmut
Stem cell-based therapies require cells with a maximum regenerative capacity in order to support regeneration after tissue injury and organ failure. Optimization of this regenerative potential of mesenchymal stromal/stem cells (MSC) or their conditioned medium by in vitro preconditioning regimens are considered to be a promising strategy to improve the release of regenerative factors. In the present study, MSC were isolated from inguinal adipose tissue (mASC) from C57BL/6 mice, cultured, and characterized. Then, mASC were either preconditioned by incubation in a hypoxic environment (0.5% O2), or in normoxia in the presence of murine epidermal growth factor (EGF) or tumor necrosis factor α (TNFα) for 48 h. Protein expression was measured by a commercially available array. Selected factors were verified by PCR analysis. The expression of 83 out of 308 proteins (26.9%) assayed was found to be increased after preconditioning with TNFα, whereas the expression of 61 (19.8%) and 70 (22.7%) proteins was increased after incubation with EGF or in hypoxia, respectively. Furthermore, we showed the proliferation-promoting effects of the preconditioned culture supernatants on injured epithelial cells in vitro. Our findings indicate that each preconditioning regimen tested induced an individual expression profile with a wide variety of factors, including several growth factors and cytokines, and therefore may enhance the regenerative potential of mASC for cell-based therapies.