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Adam, Jaroslav ; Adamová, Dagmar ; Aggarwal, Madan Mohan ; Aglieri Rinella, Gianluca ; Agnello, Michelangelo ; Agrawal, Neelima ; Ahammed, Zubayer ; Ahn, Sang Un ; Aimo, Ilaria ; Aiola, Salvatore ; Ajaz, Muhammad ; Akindinov, Alexander ; Alam, Sk Noor ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alexandre, Didier ; Alfaro Molina, Jose Ruben ; Alici, Andrea ; Alkin, Anton ; Alme, Johan ; Alt, Torsten ; Altinpinar, Sedat ; Altsybeev, Igor ; Alves Garcia Prado, Caio ; Andrei, Cristian ; Andronic, Anton ; Anguelov, Venelin ; Anielski, Jonas ; Anticic, Tome ; Antinori, Federico ; Antonioli, Pietro ; Aphecetche, Laurent Bernard ; Appelshäuser, Harald ; Arcelli, Silvia ; Armesto Perez, Nestor ; Arnaldi, Roberta ; Aronsson, Tomas ; Arsene, Ionut Cristian ; Arslandok, Mesut ; Augustinus, Andre ; Averbeck, Ralf Peter ; Azmi, Mohd Danish ; Bach, Matthias Jakob ; Badala, Angela ; Baek, Yong Wook ; Bagnasco, Stefano ; Bailhache, Raphaelle Marie ; Bala, Renu ; Baldisseri, Alberto ; Baltasar Dos Santos Pedrosa, Fernando ; 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Vanat, Tomas ; Vande Vyvre, Pierre ; Varga, Dezso ; Diozcora Vargas Trevino, Aurora ; Vargyas, Marton ; Varma, Raghava ; Vasileiou, Maria ; Vasiliev, Andrey ; Vauthier, Astrid ; Vechernin, Vladimir ; Veen, Annelies Marianne ; Veldhoen, Misha ; Velure, Arild ; Venaruzzo, Massimo ; Vercellin, Ermanno ; Vergara Limon, Sergio ; Vernet, Renaud ; Verweij, Marta ; Vickovic, Linda ; Viesti, Giuseppe ; Viinikainen, Jussi Samuli ; Vilakazi, Zabulon ; Villalobos Baillie, Orlando ; Vinogradov, Alexander ; Vinogradov, Leonid ; Vinogradov, Yury ; Virgili, Tiziano ; Vislavicius, Vytautas ; Viyogi, Yogendra ; Vodopyanov, Alexander ; Völkl, Martin Andreas ; Voloshin, Kirill ; Voloshin, Sergey ; Volpe, Giacomo ; Von Haller, Barthelemy ; Vorobyev, Ivan ; Vranic, Danilo ; Vrlakova, Janka ; Vulpescu, Bogdan ; Vyushin, Alexey ; Wagner, Boris ; Wagner, Jan ; Wang, Hongkai ; Wang, Mengliang ; Wang, Yifei ; Watanabe, Daisuke ; Weber, Michael ; Weber, Steffen Georg ; Wessels, Johannes Peter ; Westerhoff, Uwe ; Wiechula, Jens ; Wikne, Jon ; Wilde, Martin Rudolf ; Wilk, Grzegorz Andrzej ; Wilkinson, Jeremy John ; Williams, Crispin ; Windelband, Bernd ; Winn, Michael ; Yaldo, Chris G ; Yamaguchi, Yorito ; Yang, Hongyan ; Yang, Ping ; Yano, Satoshi ; Yin, Zhongbao ; Yokoyama, Hiroki ; Yoo, In-Kwon ; Yurchenko, Volodymyr ; Yushmanov, Igor ; Zaborowska, Anna ; Zaccolo, Valentina ; Zaman, Ali ; Zampolli, Chiara ; Correia Zanoli, Henrique Jose ; Zaporozhets, Sergey ; Zarochentsev, Andrey ; Zavada, Petr ; Zavyalov, Nikolay ; Zbroszczyk, Hanna Paulina ; Zgura, Sorin Ion ; Zhalov, Mikhail ; Zhang, Haitao ; Zhang, Xiaoming ; Zhang, Yonghong ; Zhao, Chengxin ; Zhigareva, Natalia ; Zhou, Daicui ; Zhou, You ; Zhou, Zhuo ; Zhu, Hongsheng ; Zhu, Jianhui ; Zhu, Xiangrong ; Zichichi, Antonino ; Zimmermann, Alice ; Zimmermann, Markus Bernhard ; Zinovjev, Gennady ; Zyzak, Maksym
We have has performed the first measurement of the coherent ψ(2S) photo-production cross section in ultra-peripheral Pb-Pb collisions at the LHC. This charmonium excited state is reconstructed via the ψ(2S) →l+l− and ψ(2S) → J/ψπ+π− decays, where the J/ψ decays into two leptons. The analysis is based on an event sample corresponding to an integrated luminosity of about 22 μb−1. The cross section for coherent ψ(2S) production in the rapidity interval −0.9<y<0.9 is dσcohψ(2S)/dy=0.83±0.19(stat+syst) mb. The ψ(2S) to J/ψ coherent cross section ratio is 0.34+0.08−0.07(stat+syst). The obtained results are compared to predictions from theoretical models.
Adam, Jaroslav ; Adamová, Dagmar ; Aggarwal, Madan Mohan ; Aglieri Rinella, Gianluca ; Agnello, Michelangelo ; Agrawal, Neelima ; Ahammed, Zubayer ; Ahn, Sang Un ; Aimo, Ilaria ; Aiola, Salvatore ; Ajaz, Muhammad ; Akindinov, Alexander ; Alam, Sk Noor ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alexandre, Didier ; Alfaro Molina, Jose Ruben ; Alici, Andrea ; Alkin, Anton ; Alme, Johan ; Alt, Torsten ; Altinpinar, Sedat ; Altsybeev, Igor ; Alves Garcia Prado, Caio ; Andrei, Cristian ; Andronic, Anton ; Anguelov, Venelin ; Anielski, Jonas ; Anticic, Tome ; Antinori, Federico ; Antonioli, Pietro ; Aphecetche, Laurent Bernard ; Appelshäuser, Harald ; Arcelli, Silvia ; Armesto Perez, Nestor ; Arnaldi, Roberta ; Aronsson, Tomas ; Arsene, Ionut Cristian ; Arslandok, Mesut ; Augustinus, Andre ; Averbeck, Ralf Peter ; Azmi, Mohd Danish ; Bach, Matthias Jakob ; Badala, Angela ; Baek, Yong Wook ; Bagnasco, Stefano ; Bailhache, Raphaelle Marie ; Bala, Renu ; Baldisseri, Alberto ; Baltasar Dos Santos Pedrosa, Fernando ; 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Khan, Mohammed Mohisin ; Khan, Palash ; Khan, Shuaib Ahmad ; Khanzadeev, Alexei ; Kharlov, Yury ; Kileng, Bjarte ; Kim, Beomkyu ; Kim, Do Won ; Kim, Dong Jo ; Kim, Hyeonjoong ; Kim, Jinsook ; Kim, Mimae ; Kim, Minwoo ; Kim, Se Yong ; Kim, Taesoo ; Kirsch, Stefan ; Kisel, Ivan ; Kiselev, Sergey ; Kisiel, Adam Ryszard ; Kiss, Gabor ; Klay, Jennifer Lynn ; Klein, Carsten ; Klein, Jochen ; Klein-Bösing, Christian ; Kluge, Alexander ; Knichel, Michael Linus ; Knospe, Anders Garritt ; Kobayashi, Taiyo ; Kobdaj, Chinorat ; Kofarago, Monika ; Kollegger, Thorsten ; Kolozhvari, Anatoly ; Kondratev, Valerii ; Kondratyeva, Natalia ; Kondratyuk, Evgeny ; Konevskikh, Artem ; Kouzinopoulos, Charalampos ; Kovalenko, Oleksandr ; Kovalenko, Vladimir ; Kowalski, Marek ; Kox, Serge ; Koyithatta Meethaleveedu, Greeshma ; Kral, Jiri ; Králik, Ivan ; Kravcakova, Adela ; Krelina, Michal ; Kretz, Matthias ; Krivda, Marian ; Krizek, Filip ; Kryshen, Evgeny ; Krzewicki, Mikolaj ; Kubera, Andrew Michael ; Kucera, Vit ; 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Sahoo, Raghunath ; Sahoo, Sarita ; Sahu, Pradip Kumar ; Saini, Jogender ; Sakai, Shingo ; Saleh, Mohammad Ahmad ; Salgado Lopez, Carlos Alberto ; Salzwedel, Jai Samuel Nielsen ; Sambyal, Sanjeev Singh ; Samsonov, Vladimir ; Sanchez Castro, Xitzel ; Sandor, Ladislav ; Sandoval, Andres ; Sano, Masato ; Santagati, Gianluca ; Sarkar, Debojit ; Scapparone, Eugenio ; Scarlassara, Fernando ; Scharenberg, Rolf Paul ; Schiaua, Claudiu Cornel ; Schicker, Rainer ; Schmidt, Christian Joachim ; Schmidt, Hans Rudolf ; Schuchmann, Simone ; Schukraft, Jürgen ; Schulc, Martin ; Schuster, Tim Robin ; Schutz, Yves Roland ; Schwarz, Kilian Eberhard ; Schweda, Kai ; Scioli, Gilda ; Scomparin, Enrico ; Scott, Rebecca Michelle ; Seeder, Karin Soraya ; Seger, Janet Elizabeth ; Sekiguchi, Yuko ; Selyuzhenkov, Ilya ; Senosi, Kgotlaesele ; Seo, Jeewon ; Serradilla Rodriguez, Eulogio ; Sevcenco, Adrian ; Shabanov, Arseniy ; Shabetai, Alexandre ; Shadura, Oksana ; Shahoyan, Ruben ; Shangaraev, Artem ; Sharma, Ankita ; Sharma, Natasha ; Shigaki, Kenta ; Shtejer Diaz, Katherin ; Sibiryak, Yury ; Siddhanta, Sabyasachi ; Sielewicz, Krzysztof Marek ; Siemiarczuk, Teodor ; Silvermyr, David Olle Rickard ; Silvestre, Catherine Micaela ; Simatovic, Goran ; Simonetti, Giuseppe ; Singaraju, Rama Narayana ; Singh, Ranbir ; Singha, Subhash ; Singhal, Vikas ; Sinha, Bikash ; Sarkar-Sinha, Tinku ; Sitar, Branislav ; Sitta, Mario ; Skaali, Toralf Bernhard ; Skjerdal, Kyrre ; Slupecki, Maciej ; Smirnov, Nikolai ; Snellings, Raimond ; Snellman, Tomas Wilhelm ; Soegaard, Carsten ; Soltz, Ron Ariel ; Song, Jihye ; Song, Myunggeun ; Song, Zixuan ; Soramel, Francesca ; Sorensen, Soren Pontoppidan ; Spacek, Michal ; Spiriti, Eleuterio ; Sputowska, Iwona Anna ; Spyropoulou-Stassinaki, Martha ; Srivastava, Brijesh Kumar ; Stachel, Johanna ; Stan, Ionel ; Stefanek, Grzegorz ; Steinpreis, Matthew Donald ; Stenlund, Evert Anders ; Steyn, Gideon Francois ; Stiller, Johannes Hendrik ; Stocco, Diego ; Strmen, Peter ; Suaide, Alexandre Alarcon do Passo ; Sugitate, Toru ; Suire, Christophe Pierre ; Suleymanov, Mais Kazim Oglu ; Sultanov, Rishat ; Sumbera, Michal ; Symons, Timothy ; Szabo, Alexander ; Szanto De Toledo, Alejandro ; Szarka, Imrich ; Szczepankiewicz, Adam ; Szymanski, Maciej ; Takahashi, Jun ; Tanaka, Naoto ; Tangaro, Marco-Antonio ; Tapia Takaki, Jesus Daniel ; Tarantola Peloni, Attilio ; Tariq, Mohammad ; Tarzila, Madalina-Gabriela ; Tauro, Arturo ; Tejeda Munoz, Guillermo ; Telesca, Adriana ; Terasaki, Kohei ; Terrevoli, Cristina ; Teyssier, Boris ; Thaeder, Jochen Mathias ; Thomas, Deepa ; Tieulent, Raphael Noel ; Timmins, Anthony Robert ; Toia, Alberica ; Trogolo, Stefano ; Trubnikov, Victor ; Trzaska, Wladyslaw Henryk ; Tsuji, Tomoya ; Tumkin, Alexandr ; Turrisi, Rosario ; Tveter, Trine Spedstad ; Ullaland, Kjetil ; Uras, Antonio ; Usai, Gianluca ; Utrobicic, Antonija ; Vajzer, Michal ; Vala, Martin ; Valencia Palomo, Lizardo ; Vallero, Sara ; Van Der Maarel, Jasper ; Van Hoorne, Jacobus Willem ; Van Leeuwen, Marco ; Vanat, Tomas ; Vande Vyvre, Pierre ; Varga, Dezso ; Diozcora Vargas Trevino, Aurora ; Vargyas, Marton ; Varma, Raghava ; Vasileiou, Maria ; Vasiliev, Andrey ; Vauthier, Astrid ; Vechernin, Vladimir ; Veen, Annelies Marianne ; Veldhoen, Misha ; Velure, Arild ; Venaruzzo, Massimo ; Vercellin, Ermanno ; Vergara Limon, Sergio ; Vernet, Renaud ; Verweij, Marta ; Vickovic, Linda ; Viesti, Giuseppe ; Viinikainen, Jussi Samuli ; Vilakazi, Zabulon ; Villalobos Baillie, Orlando ; Vinogradov, Alexander ; Vinogradov, Leonid ; Vinogradov, Yury ; Virgili, Tiziano ; Vislavicius, Vytautas ; Viyogi, Yogendra ; Vodopyanov, Alexander ; Völkl, Martin Andreas ; Voloshin, Kirill ; Voloshin, Sergey ; Volpe, Giacomo ; Von Haller, Barthelemy ; Vorobyev, Ivan ; Vranic, Danilo ; Vrlakova, Janka ; Vulpescu, Bogdan ; Vyushin, Alexey ; Wagner, Boris ; Wagner, Jan ; Wang, Hongkai ; Wang, Mengliang ; Wang, Yifei ; Watanabe, Daisuke ; Weber, Michael ; Weber, Steffen Georg ; Wessels, Johannes Peter ; Westerhoff, Uwe ; Wiechula, Jens ; Wikne, Jon ; Wilde, Martin Rudolf ; Wilk, Grzegorz Andrzej ; Wilkinson, Jeremy John ; Williams, Crispin ; Windelband, Bernd ; Winn, Michael ; Yaldo, Chris G ; Yamaguchi, Yorito ; Yang, Hongyan ; Yang, Ping ; Yano, Satoshi ; Yin, Zhongbao ; Yokoyama, Hiroki ; Yoo, In-Kwon ; Yurchenko, Volodymyr ; Yushmanov, Igor ; Zaborowska, Anna ; Zaccolo, Valentina ; Zaman, Ali ; Zampolli, Chiara ; Correia Zanoli, Henrique Jose ; Zaporozhets, Sergey ; Zarochentsev, Andrey ; Zavada, Petr ; Zavyalov, Nikolay ; Zbroszczyk, Hanna Paulina ; Zgura, Sorin Ion ; Zhalov, Mikhail ; Zhang, Haitao ; Zhang, Xiaoming ; Zhang, Yonghong ; Zhao, Chengxin ; Zhigareva, Natalia ; Zhou, Daicui ; Zhou, You ; Zhou, Zhuo ; Zhu, Hongsheng ; Zhu, Jianhui ; Zhu, Xiangrong ; Zichichi, Antonino ; Zimmermann, Alice ; Zimmermann, Markus Bernhard ; Zinovjev, Gennady ; Zyzak, Maksym
We have has performed the first measurement of the coherent ψ(2S) photo-production cross section in ultra-peripheral Pb-Pb collisions at the LHC. This charmonium excited state is reconstructed via the ψ(2S) →l+l− and ψ(2S) → J/ψπ+π− decays, where the J/ψ decays into two leptons. The analysis is based on an event sample corresponding to an integrated luminosity of about 22 μb−1. The cross section for coherent ψ(2S) production in the rapidity interval −0.9<y<0.9 is dσcohψ(2S)/dy=0.83±0.19(stat+syst) mb. The ψ(2S) to J/ψ coherent cross section ratio is 0.34+0.08−0.07(stat+syst). The obtained results are compared to predictions from theoretical models.
Forstner, Andreas Josef ; Hecker, Julian ; Hofmann, Andrea ; Maaser, Anna ; Reinbold, Céline S. ; Mühleisen, Thomas W. ; Leber, Markus ; Strohmaier, Jana ; Degenhardt, Franziska ; Treutlein, Jens ; Mattheisen, Manuel ; Schumacher, Johannes ; Streit, Fabian ; Meier, Sandra ; Herms, Stefan ; Hoffmann, Per ; Lacour, André ; Witt, Stephanie ; Reif, Andreas ; Müller-Myhsok, Bertram ; Lucae, Susanne ; Maier, Wolfgang ; Schwarz, Markus ; Vedder, Helmut ; Kammerer-Ciernioch, Jutta ; Pfennig, Andrea ; Bauer, Michael ; Hautzinger, Martin ; Moebus, Susanne ; Schenk, Lorena M. ; Fischer, Sascha B. ; Sivalingam, Sugirthan ; Czerski, Piotr M. ; Hauser, Joanna ; Lissowska, Jolanta ; Szeszenia-Dabrowska, Neonila ; Brennan, Paul E. ; McKay, James D. ; Wright, Adam ; Mitchell, Philip B. ; Fullerton, Janice M. ; Schofield, Peter R. ; Montgomery, Grant W. ; Medland, Sarah E. ; Gordon, Scott D. ; Martin, Nicholas Gordon ; Krasnov, Valery ; Chuchalin, Alexander ; Babadjanova, Gulja ; Pantelejeva, Galina ; Abramova, Lilia I. ; Tiganov, Alexander S. ; Polonikov, Alexey ; Khusnutdinova, Elza ; Alda, Martin ; Cruceanu, Cristiana ; Rouleau, Guy A. ; Turecki, Gustavo ; Laprise, Catherine ; Rivas, Fabio ; Mayoral, Fermı́n ; Kogevinas, Manolis ; Grigoroiu-Serbanescu, Maria ; Becker, Tim ; Schulze, Thomas Gerd ; Rietschel, Marcella ; Cichon, Sven ; Fier, Heide ; Nöthen, Markus Maria
Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association study (GWAS) by the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). The present study investigated whether these SCZ-associated SNPs also contribute to BD development through the performance of association testing in a large BD GWAS dataset (9747 patients, 14278 controls). After re-imputation and correction for sample overlap, 22 of 107 investigated SCZ SNPs showed nominal association with BD. The number of shared SCZ-BD SNPs was significantly higher than expected (p = 1.46x10-8). This provides further evidence that SCZ-associated loci contribute to the development of BD. Two SNPs remained significant after Bonferroni correction. The most strongly associated SNP was located near TRANK1, which is a reported genome-wide significant risk gene for BD. Pathway analyses for all shared SCZ-BD SNPs revealed 25 nominally enriched gene-sets, which showed partial overlap in terms of the underlying genes. The enriched gene-sets included calcium- and glutamate signaling, neuropathic pain signaling in dorsal horn neurons, and calmodulin binding. The present data provide further insights into shared risk loci and disease-associated pathways for BD and SCZ. This may suggest new research directions for the treatment and prevention of these two major psychiatric disorders.
Eckardt, Jan-Niklas ; Stasik, Sebastian ; Kramer, Michael ; Röllig, Christoph ; Krämer, Alwin ; Scholl, Sebastian ; Hochhaus, Andreas ; Crysandt, Martina ; Brümmendorf, Tim Henrik ; Naumann, Ralph ; Steffen, Björn ; Kunzmann, Volker ; Einsele, Hermann ; Schaich, Markus ; Burchert, Andreas ; Neubauer, Andreas ; Schäfer-Eckart, Kerstin ; Schliemann, Christoph ; Krause, Stefan W. ; Herbst, Regina ; Hänel, Mathias ; Frickhofen, Norbert ; Noppeney, Richard ; Kaiser, Ulrich ; Baldus, Claudia ; Kaufmann, Martin ; Rácil, Zdenek ; Platzbecker, Uwe ; Berdel, Wolfgang E. ; Mayer, Jiří ; Serve, Hubert ; Müller-Tidow, Carsten ; Ehninger, Gerhard ; Stölzel, Friedrich ; Kroschinsky, Frank ; Schetelig, Johannes ; Bornhäuser, Martin ; Thiede, Christian ; Middeke, Jan Moritz
Simple Summary: Acute myeloid leukemia (AML) is a genetically heterogeneous disease. Clinical phenotypes of frequent mutations and their impact on patient outcome are well established. However, the role of rare mutations often remains elusive. We retrospectively analyzed 1529 newly diagnosed and intensively treated AML patients for mutations of BCOR and BCORL1. We report a distinct co-mutational pattern that suggests a role in disease progression rather than initiation, especially affecting mechanisms of DNA-methylation. Further, we found loss-of-function mutations of BCOR to be independent markers of poor outcomes in multivariable analysis. Therefore, loss-of-function mutations of BCOR need to be considered for AML management, as they may influence risk stratification and subsequent treatment allocation.
Abstract: Acute myeloid leukemia (AML) is characterized by recurrent genetic events. The BCL6 corepressor (BCOR) and its homolog, the BCL6 corepressor-like 1 (BCORL1), have been reported to be rare but recurrent mutations in AML. Previously, smaller studies have reported conflicting results regarding impacts on outcomes. Here, we retrospectively analyzed a large cohort of 1529 patients with newly diagnosed and intensively treated AML. BCOR and BCORL1 mutations were found in 71 (4.6%) and 53 patients (3.5%), respectively. Frequently co-mutated genes were DNTM3A, TET2 and RUNX1. Mutated BCORL1 and loss-of-function mutations of BCOR were significantly more common in the ELN2017 intermediate-risk group. Patients harboring loss-of-function mutations of BCOR had a significantly reduced median event-free survival (HR = 1.464 (95%-Confidence Interval (CI): 1.005–2.134), p = 0.047), relapse-free survival (HR = 1.904 (95%-CI: 1.163–3.117), p = 0.01), and trend for reduced overall survival (HR = 1.495 (95%-CI: 0.990–2.258), p = 0.056) in multivariable analysis. Our study establishes a novel role for loss-of-function mutations of BCOR regarding risk stratification in AML, which may influence treatment allocation.
Randall, Joshua C. ; Winkler, Thomas W. ; Kutalik, Zoltán ; I. Berndt, Sonja ; Jackson, Anne U. ; Monda, Keri L. ; Kilpeläinen, Tuomas O. ; Esko, Tõnu ; Mägi, Reedik ; Li, Shengxu ; Workalemahu, Tsegaselassie ; Feitosa, Mary F. ; Croteau-Chonka, Damien C. ; Day, Felix R. ; Fall, Tove ; Ferreira, Teresa ; Gustafsson, Stefan ; Locke, Adam E. ; Mathieson, Iain ; Scherag, André ; Vedantam, Sailaja ; Wood, Andrew R. ; Liang, Liming ; Steinthorsdottir, Valgerdur ; Thorleifsson, Gudmar ; Dermitzakis, Emmanouil T. ; Dimas, Antigone S. ; Karpe, Fredrik ; Min, Josine L. ; Nicholson, George ; Clegg, Deborah J. ; Person, Thomas ; Krohn, Jon P. ; Bauer, Sabrina ; Buechler, Christa ; Eisinger, Kristina ; Bonnefond, Amélie ; Froguel, Philippe ; Hottenga, Jouke-Jan ; Prokopenko, Inga ; Waite, Lindsay L. ; Harris, Tamara B. ; Smith, Albert Vernon ; Shuldiner, Alan R. ; McArdle, Wendy L. ; Caulfield, Mark J. ; Munroe, Patricia B. ; Grönberg, Henrik ; Chen, Yii-Der Ida ; Li, Guo ; Beckmann, Jacques S. ; Johnson, Toby ; Thorsteinsdottir, Unnur ; Teder-Laving, Maris ; Khaw, Kay-Tee ; Wareham, Nicholas J. ; Zhao, Jing Hua ; Amin, Najaf ; Oostra, Ben A. ; Kraja, Aldi T. ; Province, Michael A. ; Cupples, L. Adrienne ; Heard-Costa, Nancy L. ; Kaprio, Jaakko ; Ripatti, Samuli ; Surakka, Ida ; Collins, Francis S. ; Saramies, Jouko ; Tuomilehto, Jaakko ; Jula, Antti ; Salomaa, Veikko ; Erdmann, Jeanette ; Hengstenberg, Christian ; Loley, Christina ; Schunkert, Heribert ; Lamina, Claudia ; Wichmann, Heinz Erich ; Albrecht, Eva ; Gieger, Christian ; Hicks, Andrew A. ; Johansson, Åsa ; Pramstaller, Peter P. ; Kathiresan, Sekar ; Speliotes, Elizabeth K. ; Penninx, Brenda W. J. H. ; Hartikainen, Anna-Liisa ; Jarvelin, Marjo-Riitta ; Gyllensten, Ulf ; Boomsma, Dorret I. ; Campbell, Harry ; Wilson, James F. ; Chanock, Stephen J. ; Farrall, Martin ; Goel, Anuj ; Medina-Gomez, Carolina ; Rivadeneira, Fernando ; Estrada, Karol ; Uitterlinden, André G. ; Hofman, Albert ; Zillikens, M. Carola ; Heijer, Martin den ; Kiemeney, Lambertus Adrianus ; Maschio, Andrea ; Hall, Per ; Tyrer, Jonathan ; Teumer, Alexander ; Völzke, Henry ; Kovacs, Peter ; Tönjes, Anke ; Mangino, Massimo ; Spector, Tim D. ; Hayward, Caroline ; Rudan, Igor ; Hall, Alistair S. ; Samani, Nilesh J. ; Attwood, Antony Paul ; Sambrook, Jennifer G. ; Hung, Joseph ; Palmer, Lyle J. ; Lokki, Marja-Liisa ; Sinisalo, Juha ; Boucher, Gabrielle ; Huikuri, Heikki ; Lorentzon, Mattias ; Ohlsson, Claes ; Eklund, Niina ; Eriksson, Johan G. ; Barlassina, Cristina ; Rivolta, Carlo ; Nolte, Ilja M. ; Snieder, Harold ; Klauw, Melanie M. van der ; Vliet-Ostaptchouk, Jana V. van ; Gejman, Pablo V. ; Shi, Jianxin ; Jacobs, Kevin B. ; Wang, Zhaoming ; Bakker, Stephan J. L. ; Mateo Leach, Irene ; Navis, Gerjan ; Harst, Pim van der ; Martin, Nicholas Gordon ; Medland, Sarah E. ; Montgomery, Grant W. ; Yang, Jian ; Chasman, Daniel I. ; Ridker, Paul M. ; Rose, Lynda M. ; Lehtimäki, Terho ; Raitakari, Olli ; Absher, Devin ; Iribarren, Carlos ; Basart, Hanneke ; Hovingh, Kees G. ; Hyppönen, Elina ; Power, Chris ; Power, Chris ; Anderson, Denise ; Beilby, John P. ; Hui, Jennie ; Jolley, Jennifer ; Sager, Hendrik ; Bornstein, Stefan R. ; Schwarz, Peter E. H. ; Kristiansson, Kati ; Perola, Markus ; Lindström, Jaana ; Swift, Amy J. ; Uusitupa, Matti ; Atalay, Mustafa ; Lakka, Timo A. ; Rauramaa, Rainer ; Bolton, Jennifer L. ; Fowkes, Gerry ; Fraser, Ross M. ; Price, Jackie F. ; Fischer, Krista ; KrjutÅ¡kov, Kaarel ; Metspalu, Andres ; Mihailov, Evelin ; Langenberg, Claudia ; Luan, Jian'an ; Ong, Ken K. ; Chines, Peter S. ; Keinanen-Kiukaanniemi, Sirkka M. ; Saaristo, Timo E. ; Edkins, Sarah ; Franks, Paul W. ; Hallmans, Göran ; Shungin, Dmitry ; Morris, Andrew David ; Palmer, Colin N. A. ; Erbel, Raimund ; Moebus, Susanne ; Nöthen, Markus Maria ; Pechlivanis, Sonali ; Hveem, Kristian ; Narisu, Narisu ; Hamsten, Anders ; Humphries, Steve E. ; Strawbridge, Rona J. ; Tremoli, Elena ; Grallert, Harald ; Thorand, Barbara ; Illig, Thomas ; Koenig, Wolfgang ; Müller-Nurasyid, Martina ; Peters, Annette ; Böhm, Bernhard O. ; Kleber, Marcus E. ; März, Winfried ; Winkelmann, Bernhard R. ; Kuusisto, Johanna ; Laakso, Markku ; Arveiler, Dominique ; Cesana, Giancarlo ; Kuulasmaa, Kari ; Virtamo, Jarmo ; Yarnell, John W. G. ; Kuh, Diana ; Wong, Andrew ; Lind, Lars ; Faire, Ulf de ; Gigante, Bruna ; Magnusson, Patrik K. E. ; Pedersen, Nancy L. ; Dedoussis, George ; Dimitriou, Maria ; Kolovou, Genovefa ; Kanoni, Stavroula ; Stirrups, Kathleen ; Bonnycastle, Lori L. ; Njølstad, Inger ; Wilsgaard, Tom ; Ganna, Andrea ; Rehnberg, Emil ; Hingorani, Aroon ; Kivimaki, Mika ; Kumari, Meena ; Assimes, Themistocles L. ; Barroso, Inês ; Boehnke, Michael ; Borecki, Ingrid B. ; Deloukas, Panos ; Fox, Caroline S. ; Frayling, Timothy ; Groop, Leif C. ; Haritunians, Talin ; Hunter, David ; Ingelsson, Erik ; Kaplan, Robert ; Mohlke, Karen L. ; North, Kari E. ; Lindgren, Cecilia M. ; Qi, Lu ; Loos, Ruth J. F. ; Heid, Iris M. ; Hirschhorn, Joel N. ; McCarthy, Mark I. ; Abecasis, Gonçalo R. ; Stefansson, Kari ; Strachan, David P. ; Schlessinger, David ; O'Connell, Jeffrey R. ; Duijn, Cornelia M. van
Men and women differ substantially regarding height, weight, and body fat. Interestingly, previous work detecting genetic effects for waist-to-hip ratio, to assess body fat distribution, has found that many of these showed sex-differences. However, systematic searches for sex-differences in genetic effects have not yet been conducted. Therefore, we undertook a genome-wide search for sexually dimorphic genetic effects for anthropometric traits including 133,723 individuals in a large meta-analysis and followed promising variants in further 137,052 individuals, including a total of 94 studies. We identified seven loci with significant sex-difference including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were significant in women, but not in men. Of interest is that sex-difference was only observed for waist phenotypes, but not for height or body-mass-index. We found no evidence for sex-differences with opposite effect direction for men and women. The PPARG locus is of specific interest due to its link to diabetes genetics and therapy. Our findings demonstrate the importance of investigating sex differences, which may lead to a better understanding of disease mechanisms with a potential relevance to treatment options.
White, Helen ; Deprez, Liesbet ; Corbisier, Philippe ; Hall, Victoria ; Lin, Feng ; Mazoua, Stéphane ; Trapmann, Stefanie ; Aggerholm, Anni ; Andrikovics, Hajnalka ; Akiki, Susanna ; Barbany, Gisela ; Boeckx, Nancy ; Bench, Anthony ; Catherwood, Mark ; Cayuela, Jean-Michel ; Chudleigh, Sandra ; Clench, Tim ; Colomer, Dolors ; Daraio, Filomena ; Dulucq, Stephanie ; Farrugia, Joanna ; Fletcher, Linda ; Foroni, Letizia ; Ganderton, Ros ; Gerrard, Gareth ; Gineikienė, Eglė ; Hayette, Sandrine ; El Housni, Hakim ; Izzo, Barbara ; Jansson, Mattias ; Johnels, Petra ; Jurcek, Tomas ; Kairisto, Veli ; Kizilors, Aytug ; Kim, Dong-Wook ; Lange, Thoralf ; Lion, Thomas ; Polakova, Katerina Machova ; Martinelli, Giovanni ; McCarron, Sarah ; Merle, Pauline A. ; Milner, Ben ; Mitterbauer-Hohendanner, Gerlinde ; Nagar, Meital ; Nickless, Guillermina ; Nomdedéu, Josep F. ; Nymoen, Dag A. ; Leibundgut, Elisabeth Oppliger ; Ozbek, Ugur ; Pajič, Tadej ; Pfeifer, Heike ; Preudhomme, Claude ; Raudsepp, Kadri ; Romeo, Giuliana ; Sacha, Tomasz ; Talmaci, Rodica ; Touloumenidou, Tasoula ; Van der Velden, Vincent H. J. ; Waits, Paula ; Wang, Lihui ; Wilkinson, Elizabeth ; Wilson, Gill ; Wren, Dörte ; Zadro, Renata ; Ziermann, Janine ; Zoi, Katerina ; Müller, Martin C. ; Hochhaus, Andreas ; Schimmel, Heinz ; Cross, Nicholas C. P. ; Emons, Hendrik
Serial quantification of BCR–ABL1 mRNA is an important therapeutic indicator in chronic myeloid leukaemia, but there is a substantial variation in results reported by different laboratories. To improve comparability, an internationally accepted plasmid certified reference material (CRM) was developed according to ISO Guide 34:2009. Fragments of BCR–ABL1 (e14a2 mRNA fusion), BCR and GUSB transcripts were amplified and cloned into pUC18 to yield plasmid pIRMM0099. Six different linearised plasmid solutions were produced with the following copy number concentrations, assigned by digital PCR, and expanded uncertainties: 1.08±0.13 × 106, 1.08±0.11 × 105, 1.03±0.10 × 104, 1.02±0.09 × 103, 1.04±0.10 × 102 and 10.0±1.5 copies/μl. The certification of the material for the number of specific DNA fragments per plasmid, copy number concentration of the plasmid solutions and the assessment of inter-unit heterogeneity and stability were performed according to ISO Guide 35:2006. Two suitability studies performed by 63 BCR–ABL1 testing laboratories demonstrated that this set of 6 plasmid CRMs can help to standardise a number of measured transcripts of e14a2 BCR–ABL1 and three control genes (ABL1, BCR and GUSB). The set of six plasmid CRMs is distributed worldwide by the Institute for Reference Materials and Measurements (Belgium) and its authorised distributors (https://ec.europa.eu/jrc/en/reference-materials/catalogue/; CRM code ERM-AD623a-f).
Ein Wachstumshormonmangel im Erwachsenenalter führt sowohl im Stoffwechsel als auch in der Psyche zu negativen Veränderungen, die Genese des GH-Mangels spielt keine Rolle. Die vorliegende Arbeit untersuchte, ob es bei Patienten mit einem GH-Mangel im Erwachsenenalter durch die Substitution mit rekombinantem humanen Wachstumshormon zu Beeinflussungen der in der vorliegenden Studie untersuchten Parameter kommt. Diese Patienten wurden zum Teil (80%) als Kind mit WH behandelt und in einem Zeitraum von 12 Monaten bis zu 18 Jahren nach Abbruch der Therapie erneut diagnostisch getestet (Insulin Hypoglykämie Test, L-Arginin-Test, Pyridostigmin Plus Releasing Hormone[GHRH]-Test) und resubstituiert. Um der Frage nachzugehen, welche Auswirkungen GH auf diese Patienten hat, wurden 10 Patienten in der endokrinologischen Ambulanz in Frankfurt/ Main über einen Zeitraum von 2-3 Jahren unter ansteigender GH-Substitution beobachtet. Diese Patienten waren zwischen 20-40 Jahre alt und wurden zum Teil zuvor in der Pädiatrie der Johann Wolfgang Goethe-Universität Frankfurt/Main betreut. Es wurden Laborparameter des Fettstoffwechsels (Triglyceride, Gesamtcholesterin, LDL-Cholesterin, HDL-Cholesterin), des Kohlenhydratstoffwechsels (HbA1c) und des Knochenstoffwechsels (Osteocalcin, C1CP, BAP) vor und alle 6 Monate nach Substitution von WH untersucht. Es zeigte sich eine positive Beeinflussung sowohl des Fett- (s. 3.2.10.) als auch des Knochenstoffwechsels (s. 3.2.7.). Die positiven Auswirkungen auf den Fettstoffwechsel im Sinne einer Vorbeugung kardiovaskulärer Erkrankungen wurden durch eine Senkung des Gesamtcholesterins und LDL-Cholesterin-Wertes und Anhebung des HDL-Cholesterin-Wertes erreicht. Durch eine Steigerung des Osteocalcins, des C1CP-Wertes und des BAP-Wertes mit einer Zunahme der Knochendichte im Sinne einer Prophylaxe osteoporotischer Erkrankungen über eine GH-Substitution, erklärt sich der günstige Einfluss auf den Knochenstoffwechsel. Der HbA1c-Wert (s. 3.2.6.) wurde zwar gesenkt, eine Aussage über die klinische Relevanz kann im Rahmen der vorliegen Studie nicht gemacht werden. Weitere Untersuchungen in größeren Studien sind hierfür notwendig. Zu Veränderungen im Bereich der Gerinnung und des Blutbildes kam es nicht (s. 3.2.3. u. 3.2.4.). Ein anderer Aspekt dieser Studie war die Prüfung von Veränderungen der Körperzusammensetzung durch GH. Diese Messungen wurden anhand der BIA (Bioelektrische Impedanzanalyse, s. 2.2.5.) durchgeführt. Es bestätigten sich frühere Ergebnisse, die eine Beeinflussung der Körperzusammensetzung unter GH-Substitution beschrieben (s. 3.2.2.). Die psychische Komponente wurde durch Fragebögen zur Beurteilung der Lebensqualität anhand soziologischer, psychischer und auch physischer Komponenten geprüft. Eine Tendenz zur positiven Beeinflussung der körperlichen und geistigen Leistungsfähigkeit sowie der Konzentrationsleistungen lässt sich erkennen (s. 3.2.8.), obwohl die Ergebnisse stark variieren. Zu diskutieren wäre, inwieweit es sich um primäre oder sekundäre Effekte durch positive somatische Einflüsse der GH-Substitution handelt. Das EKG wurde in dieser Studie als Beurteilungsparameter für eventuelle kardiomorphologische Veränderungen während der GH-Substitution herangezogen; im Gegensatz zu anderen Studien konnten keine Einflüsse beobachtet werden (s. 3.2.9.). In ihrer Gesamtheit zeigen die Ergebnisse, dass eine GH-Substitution im Erwachsenenalter bei GH-Mangel einen positiven Effekt auf die Körperzusammensetzung, den Kohlenhydratstoffwechsel, den Knochenstoffwechsel, die Lebensqualität und den Fettstoffwechsel hat. Eine teilweise große Divergenz in den Resultaten der Prüfwerte erklärt sich durch zufällig auftretende Faktoren bzw. interindividuelle Unterschiede in einer kleinen Prüfgruppe. Weitere Studien in größerem Rahmen wären zur Klärung der aufgetretenen Divergenzen notwendig.
Long-range angular correlations on the near and away side in p–Pb collisions at √sNN=5.02 TeV
(2013)
Abelev, Betty ; Adam, Jaroslav ; Adamová, Dagmar ; Marshall Adare, Andrew ; Aggarwal, Madan Mohan ; Aglieri Rinella, Gianluca ; Agnello, Michelangelo ; Gabor Agocs, Andras ; Agostinelli, Andrea ; Ahammed, Zubayer ; Ahmad, Nazeer ; Ahmad, Arshad ; Ahn, Sul-Ah ; Ahn, Sang Un ; Ajaz, Muhammad ; Akindinov, Alexander ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alici, Andrea ; Alkin, Anton ; Jonathan Almaraz Avina, Erick ; Alme, Johan ; Alt, Torsten ; Altini, Valerio ; Altinpinar, Sedat ; Altsybeev, Igor ; Andrei, Cristian ; Andronic, Anton ; Anguelov, Venelin ; Anielski, Jonas ; Daniel Anson, Christopher ; Antičić, Tome ; Antinori, Federico ; Antonioli, Pietro ; Aphecetche, Laurent Bernard ; Appelshäuser, Harald ; Arbor, Nicolas ; Arcelli, Silvia ; Arend, Andreas ; Armesto, Nestor ; Arnaldi, Roberta ; Robert Aronsson, Tomas ; Arsene, Ionut Cristian ; Arslandok, Mesut ; Asryan, Andzhey ; Augustinus, Andre ; Averbeck, Ralf Peter ; Awes, Terry ; Heikki Aysto, Juha ; Danish Azmi, Mohd ; Jakob Bach, Matthias ; Badalà, Angela ; Baek, Yong Wook ; Bailhache, Raphaëlle ; Bala, Renu ; Baldini Ferroli, Rinaldo ; Baldisseri, Alberto ; Baltasar Dos Santos Pedrosa, Fernando ; Ban, Jaroslav ; Chandra Baral, Rama ; Barbera, Roberto ; Barile, Francesco ; Barnaföldi, Gergely Gábor ; Stuart Barnby, Lee ; Barret, Valerie ; Gustaw Bartke, Jerzy ; Basile, Maurizio ; Bastid, Nicole ; Basu, Sumit ; Bathen, Bastian ; Batigne, Guillaume ; Batyunya, Boris ; Heinrich Baumann, Christoph ; Gardner Bearden, Ian ; Beck, Hans ; Kumar Behera, Nirbhay ; Belikov, Iouri ; Bellini, Francesca ; Bellwied, Rene ; Belmont-Moreno, Ernesto ; Bencédi, Gyula ; Beolè, Stefania ; Berceanu, Ionela ; Bercuci, Alexandru ; Berdnikov, Yaroslav ; Berényi, Dániel ; Annick Erica Bergognon, Anais ; Berzano, Dario ; Betev, Latchezar ; Bhasin, Anju ; Kumar Bhati, Ashok ; Bhom, Jihyun ; Bianchi, Livio ; Bianchi, Nicola ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bilandzic, Ante ; Bjelogrlic, Sandro ; Blanco, Francesco ; Blanco, Fernando ; Blau, Dmitry S. ; Blume, Christoph ; Boccioli, Marco ; Boettger, Stefan ; Bogdanov, Alexey A. ; Bøggild, Hans ; Bogolyubsky, Mikhail ; Boldizsar, Laszlo ; Bombara, Marek ; Book, Julian ; Borel, Herve ; Borissov, Alexander ; Bossú, Francesco ; Botje, Michiel ; Botta, Elena ; Braidot, Ermes ; Braun-Munzinger, Peter ; Bregant, Marco ; Breitner, Timo Gunther ; Alexander Broker, Theo ; Allen Browning, Tyler ; Broz, Michal ; Brun, Rene ; Bruna, Elena ; Eugenio Bruno, Giuseppe ; Budnikov, Dmitry ; Büsching, Henner ; Bufalino, Stefania ; Bunčić, Predrag ; Busch, Oliver ; Buthelezi, Edith Zinhle ; Caballero Orduna, Diego ; Caffarri, Davide ; Cai, Xu ; Caines, Helen Louise ; Calvo Villar, Ernesto ; Camerini, Paolo ; Canoa Roman, Veronica ; Cara Romeo, Giovanni ; Carena, Wisla ; Carena, Francesco ; Carlin Filho, Nelson ; Carminati, Federico ; Ofelia Casanova Diaz, Amaya ; Castillo Castellanos, Javier Ernesto ; Castillo Hernández, Juan Francisco ; Anna Rita Casula, Ester ; Catanescu, Vasile ; Cavicchioli, Costanza ; Ceballos Sanchez, Cesar ; Čepila, Jan ; Cerello, Piergiaio ; Chang, Beomsu ; Chapeland, Sylvain ; Fernand Charvet, Jean-Luc ; Chattopadhyay, Sukalyan ; Chattopadhyay, Subhasis ; Chawla, Isha ; Gerard Cherney, Michael ; Cheshkov, Cvetan ; Cheynis, Brigitte ; Miguel Chibante Barroso, Vasco ; Chinellato, David Dobrigkeit ; Chochula, Peter ; Chojnacki, Marek ; Choudhury, Subikash ; Christakoglou, Panagiotis ; Christensen, Christian Holm ; Christiansen, Peter L. ; Chujo, Tatsuya ; Chung, Suh-Urk ; Cicalò, Corrado ; Cifarelli, Luisa ; Cindolo, Federico ; Willy Andre Cleymans, Jean ; Coccetti, Fabrizio ; Colamaria, Fabio Filippo ; Colella, Domenico ; Collu, Alberto ; Conesa Balbastre, Gustavo ; Conesa del Valle, Zaida ; Elizabeth Connors, Megan ; Contin, Giacomo ; Contreras Nuno, Jesus Guillermo ; Cormier, Thomas Michael ; Corrales Morales, Yasser ; Cortese, Pietro ; Cortes Maldonado, Ismael ; Rogerio Cosentino, Mauro ; Costa, Filippo ; Enrique Cotallo, Manuel ; Crescio, Elisabetta ; Crochet, Philippe ; Cruz Alaniz, Emilia ; Cruz Albino, Rigoberto ; Cuautle, Eleazar ; Cunqueiro Mendez, Leticia ; Dainese, Andrea ; Dalsgaard, Hans Hjersing ; Danu, Andrea ; Das, Indranil ; Das, Debasish ; Das, Supriya ; Das, Kushal ; Kumar Dash, Ajay ; Dash, Sadhana ; De, Sudipan ; de Barros, Gabriel ; De Caro, Annalisa ; De Cataldo, Giacinto ; Cuveland, Jan de ; De Falco, Alessandro ; De Gruttola, Daniele ; Delagrange, Hugues ; Deloff, Andrzej ; De Marco, Nora ; Denes, Ervin ; De Pasquale, Salvatore ; Deppman, Airton ; DʼErasmo, Ginevra ; Stefan de Rooij, Raoul ; Angel Diaz Corchero, Miguel ; Di Bari, Domenico ; Dietel, Thomas ; Di Giglio, Carmelo ; Di Liberto, Sergio ; Di Mauro, Antonio ; Di Nezza, Pasquale ; Divià, Roberto ; Djuvsland, Øystein ; Florin Dobrin, Alexandru ; Antoni Dobrowolski, Tadeusz ; Donigus, Benjamin ; Dordic, Olja ; Driga, Olga ; Kumar Dubey, Anand ; Dubla, Andrea ; Ducroux, Laurent ; Dupieux, Pascal ; Dutta Majumdar, A.K. ; Elia, Domenico ; Philip Emschermann, David ; Engel, Heiko ; Erazmus, Barbara ; Austrheim Erdal, Hege ; Espagnon, Bruno ; Danielle Estienne, Magali ; Esumi, ShinIchi ; Evans, David ; Eyyubova, Gyulnara ; Fabris, Daniela ; Faivre, Julien ; Falchieri, Davide ; Fantoni, Alessandra ; Fasel, Markus ; Worsley Fearick, Roger ; Fehlker, Dominik ; Feldkamp, Linus ; Felea, Daniel ; Feliciello, Alessandro ; Fenton-Olsen, Bo ; Feofilov, Grigory ; Fernández Téllez, Arturo ; Ferretti, Alessandro ; Festanti, Andrea ; Figiel, Jan ; Figueredo, Marcel ; Filchagin, Sergey ; Finogeev, Dmitry ; Fionda, Fiorella Maria Celeste ; Enrichetta, Maria Fiore ; Floratos, Emmanuel ; Floris, Michele ; Foertsch, Siegfried Valentin ; Foka, Panagiota ; Fokin, Sergey ; Fragiacomo, Enrico ; Francescon, Andrea ; Michael Frankenfeld, Ulrich ; Fuchs, Ulrich ; Furget, Christophe ; Fusco Girard, Mario ; Gaardhøje, Jens Jørgen ; Gagliardi, Martino ; Gago Medina, Alberto Martín ; Gallio, Mauro ; Gangadharan, Dhevan Raja ; Ganoti, Paraskevi ; Garabatos Cuadrado, Jose Maria ; Garcia-Solis, Edmundo ; Garishvili, Irakli ; Gerhard, Jochen ; Germain, Marie ; Geuna, Claudio ; Gheata, Mihaela ; Gheata, Andrei George ; Ghidini, Bruno ; Ghosh, Premomoy ; Gianotti, Paola ; Robert Girard, Martin ; Giubellino, Paolo ; Gładysz-Dziaduś, Ewa ; Glässel, Peter ; Gomez, Ramon ; Gonzalez Ferreiro, Elena ; Helena Gonzalez-Trueba, Laura ; González Zamora, Pedro ; Gorbunov, Sergey ; Goswami, Ankita ; Gotovac, Sven ; Graczykowski, Łukasz Kamil ; Grajcarek, Robert ; Grelli, Alessandro ; Grigoraș, Costin ; Gabriela Grigoras, Alina ; Grigoriev, Vladislav A. ; Grigoryan, Ara ; Grigoryan, Smbat ; Grinyov, Boris ; Grion, Nevio ; Gros, Philippe ; Große-Oetringhaus, Jan Fiete ; Grossiord, Jean-Yves ; Grosso, Raffaele ; Guber, Fedor ; Guernane, Rachid ; Guerzoni, Barbara ; Rene Joseph Guilbaud, Maxime ; Herlache Gulbrandsen, Kristjan ; Gulkanyan, Hrant ; Gunji, Taku ; Gupta, Anik ; Gupta, Ramni ; Haake, Rüdiger ; Senneset Haaland, Oystein ; Marie Hadjidakis, Cynthia ; Haiduc, Maria ; Hamagaki, Hideki ; Hamar, Gergö ; Han, Byounghee ; David Hanratty, Luke ; Hansen, Alexander ; Harmanova, Zuzana ; William Harris, John ; Hartig, Matthias ; Harton, Austin ; Hatzifotiadou, Despoina ; Hayashi, Shinichi ; Hayrapetyan, Arsen ; Heckel, Stefan Thomas ; Ansgar Heide, Markus ; Helstrup, Håvard ; Ionut Herghelegiu, Andrei ; Antonio Herrera Corral, Gerardo ; Herrmann, Norbert ; Hess, Benjamin Andreas ; Hetland, Kristin Fanebust ; Hicks, Bernard ; Hippolyte, Boris ; Hori, Yasuto ; Zahariev Hristov, Peter ; Hrivnacova, Ivana ; Huang, Meidana ; Humanic, Thomas J. ; Sung Hwang, Dae ; Ichou, Raphaelle ; Ilkaev, Radiy ; Ilkiv, Iryna ; Inaba, Motoi ; Incani, Elisa ; Giaio Innocenti, Pier ; Michele Innocenti, Gian ; Ippolitov, Mikhail ; Irfan, Muhammad ; Geae Ivan, Cristian ; Ivanov, Vladimir ; Ivanov, Andrey ; Ivanov, Marian ; Ivanytskyi, Oleksii ; Wlodzimierz Jacholkowski, Adam ; Jacobs, Peter ; Jin Jang, Haeng ; Anna Janik, Malgorzata ; Janik, Rudolf ; Jayarathna, Sandun ; Jena, Satyajit ; Manu Jha, Deeptanshu ; Tonatiuh Jimenez Bustamante, Raul ; Graham Jones, Peter ; Taik Jung, Hyung ; Jusko, Anton ; Kaidalov, Alexei ; Kalcher, Sebastian ; Kalinak, Peter ; Esa Aukusti Kalliokoski, Tuomo ; Kalweit, Alexander Philipp ; Hwan Kang, Ju ; Kaplin, Vladimir ; Karasu Uysal, Ayben ; Karavichev, Oleg V. ; Karavicheva, Tatiana L. ; Karpechev, Evgeny ; Kazantsev, Andrey ; Kebschull, Udo ; Keidel, Ralf ; Khan, Palash ; Ahmad Khan, Shuaib ; Mohammed Khan, Mohisin ; Hussain Khan, Kamal ; Khanzadeev, Alexei ; Kharlov, Yury ; Kileng, Bjarte ; Kim, Beomkyu ; Sook Kim, Jin ; Kim, Jonghyun ; Jo Kim, Dong ; Won Kim, Do ; Kim, Taesoo ; Yong Kim, Se ; Kim, Mimae ; Kim, Minwoo ; Kirsch, Stefan ; Kisel, Ivan ; Kiselev, Sergej N. ; Ryszard Kisiel, Adam ; Lynn Klay, Jennifer ; Klein, Jochen ; Klein-Bösing, Christian ; Kliemant, Michael ; Kluge, Alexander ; Linus Knichel, Michael ; Garritt Knospe, Anders ; Kohler, Markus ; Kollegger, Thorsten ; Kolojvari, Anatoly ; Kompaniets, Mikhail ; Kondratiev, Valery ; Kondratyeva, Natalia ; Konevskih, Artem ; Kovalenko, Vladimir ; Kowalski, Marek ; Kox, Serge ; Koyithatta Meethaleveedu, Greeshma ; Kral, Jiří ; Králik, Ivan ; Kramer, Frederick ; Kravčáková, Adela ; Krawutschke, Tobias ; Křelina, Michal ; Kretz, Matthias ; Krivda, Marian ; Krizek, Filip ; Krus, Miroslav ; Kryshen, Evgeny ; Krzewicki, Mikolaj ; Kucheriaev, Yury ; Kugathasan, Thanushan ; Claude Kuhn, Christian ; Kuijer, Paul ; Kulakov, Igor ; Kumar, Jitendra ; Kurashvili, Podist ; Kurepin, Alexander ; Kurepin, Alexey B. ; Kuryakin, Alexey ; Kushpil, Svetlana ; Kushpil, Vasily ; Kvaerno, Henning ; Jung Kweon, Min ; Kwon, Youngil ; Ladron de Guevara, Pedro ; Lakomov, Igor ; Langoy, Rune ; Louise La Pointe, Sarah ; Ernesto Lara, Camilo ; Xavier Lardeux, Antoine ; La Rocca, Paola ; Lea, Ramona ; Lechman, Mateusz ; Sang Lee, Ki ; Chul Lee, Sung ; Richard Lee, Graham ; Legrand, Iosif ; Walter Lehnert, Joerg ; Laurent Lenhardt, Matthieu ; Lenti, Vito ; Leon, Hermes ; Leon Monzon, Ildefonso ; Leon Vargas, Hermes ; Lévai, Peter ; Li, Shuang ; Lien, Jaen ; Lietava, Roman ; Lindal, Svein ; Lindenstruth, Volker ; Lippmann, Christian ; Annan Lisa, Michael ; Martin Ljunggren, Hans ; Loenne, Per-Ivar ; Loggins, Vera ; Loginov, Vitaly ; Lohner, Daniel ; Loizides, Constantinos ; Krister Loo, Kai ; Bernard Lopez, Xavier ; López Torres, Ernesto ; Lovhoiden, Gunnar ; Lu, Xianguo ; Luettig, Philipp ; Lunardon, Marcello ; Luo, Jiebin ; Luparello, Grazia ; Luzzi, Cinzia ; Ma, Rongrong ; Ma, Ke ; Minthaka Madagodahettige-Don, Dilan ; Maevskaya, Alla ; Mager, Magnus ; Mahapatra, Durga Prasad ; Maire, Antonin ; Malaev, Mikhail ; Alicia Maldonado Cervantes, Ivonne ; Malinina, Liudmila ; MalʼKevich, Dmitry ; Malzacher, Peter ; Mamonov, Alexander ; Henri Antoine Manceau, Loic ; Kumar Mangotra, Lalit ; Manko, Vladislav ; Manso, Franck ; Manzari, Vito ; Mao, Yaxian ; Marchisone, Massimiliano ; Mareš, Jiří ; Margagliotti, Giacomo Vito ; Margotti, Anselmo ; Maria Marin, Ana ; Markert, Christina ; Marquard, Marco ; Martashvili, Irakli ; Alice Martin, Nicole ; Martinengo, Paolo ; Ivan Martinez, Mario Ivan ; Martinez Davalos, Arnulfo ; Martínez Garcia, Ginés ; Martynov, Yevgen ; Jean-Michel Mas, Alexis ; Masciocchi, Silvia ; Masera, Massimo ; Masoni, Alberto ; Marie Massacrier, Laure ; Mastroserio, Annalisa ; Tomasz Matyja, Adam ; Mayer, Christoph ; Mazer, Joel ; Maria Mazzoni, Alessandra ; Meddi, Franco ; Alejandro Menchaca-Rocha, Arturo ; Mercado Perez, Jae ; Meres, Michal ; Miake, Yasuo ; Milano, Leonardo ; Milošević, Jovan ; Mischke, André ; Nath Mishra, Aditya ; Miśkowiec, Dariusz Czesław ; Mihai Mitu, Ciprian ; Mizuno, Sanshiro ; Mlynarz, Jocelyn ; Mohanty, Bedangadas ; Molnar, Levente ; Manuel Montano Zetina, Luis ; Monteno, Marco ; Montes Prado, Esther ; Moon, Taebong ; Morando, Maurizio ; Aparecida Moreira De Godoy, Denise ; Moretto, Sandra ; Morreale, Astrid ; Morsch, Andreas ; Muccifora, Valeria ; Mudnic, Eugen ; Muhuri, Sanjib ; Mukherjee, Maitreyee ; Muller, Hans ; Munhoz, Marcelo ; Murray, Sean ; Musa, Luciano ; Musinsky, Jan ; Musso, Alfredo ; Kumar Nandi, Basanta ; Nania, Rosario ; Nappi, Eugenio ; Nattrass, Christine ; Kumar Nayak, Tapan ; Nazarenko, Sergey ; Nedosekin, Alexander ; Nicassio, Maria ; Niculescu, Mihai ; Svane Nielsen, Bae ; Niida, Takafumi ; Nikolaev, Sergey ; Nikolic, Vedran ; Nikulin, Sergey ; Nikulin, Vladimir ; Steven Nilsen, Bjorn ; Stormo Nilsson, Mads ; Noferini, Francesco ; Nomokonov, Petr V. ; Nooren, Gerardus ; Novitzky, Norbert ; Nyanin, Alexandre ; Nyatha, Anitha ; Nygaard, Casper ; Nystrand, Joakim Ingemar ; Ochirov, Alexander ; Oskar Oeschler, Helmut ; Oh, Saehanseul ; Kun Oh, Sun ; Oleniacz, Janusz ; Carlos Oliveira Da Silva, Antonio ; Oppedisano, Chiara ; Ortiz Velasquez, Antonio ; Nils Erik Oskarsson, Anders ; Krystian Ostrowski, Piotr ; Tomasz Otwinowski, Jacek ; Oyama, Ken ; Ozawa, Kyoichiro ; Chiara Pachmayer, Yvonne ; Pachr, Milos ; Padilla, Fatima ; Pagano, Paola ; Paic, Guy ; Painke, Florian ; Pajares Vales, Carlos ; Kumar Pal, Susanta ; Singh Palaha, Arvinder ; Palmeri, Armando ; Papikyan, Vardanush ; Pappalardo, Giuseppe Salvatore ; Jin Park, Woo ; Passfeld, Annika ; Pastircak, Blahoslav ; Ivanovich Patalakha, Dmitri ; Paticchio, Vincenzo ; Paul, Biswarup ; Pavlinov, Alexei ; Pawlak, Tomasz Jan ; Peitzmann, Thomas ; Denis Antonio Pereira Da Costa, Hugo ; Pereira De Oliveira Filho, Elienos ; Peresunko, Dmitri ; Eugenio Perez Lara, Carlos ; Perini, Diego ; Perrino, Davide ; Stanislaw Peryt, Wiktor ; Pesci, Alessandro ; Peskov, Vladimir ; Pestov, Yury N. ; Petráček, Vojtech ; Petran, Michal ; Petris, Mariana ; Rumenov Petrov, Plamen ; Petrovici, Mihai A. ; Petta, Catia ; Piano, Stefano ; Pikna, Miroslav ; Pillot, Philippe ; Pinazza, Ombretta ; Pinsky, Lawrence ; Pitz, Nora ; Piyarathna, Danthasinghe ; Planinic, Mirko ; Ploskon, Mateusz Andrzej ; Marian Pluta, Jan ; Pocheptsov, Timur ; Pochybova, Sona ; Luis Manuel Podesta Lerma, Pedro ; Poghosyan, Martin G. ; Polak, Karel ; Polichtchouk, Boris ; Pop, Amalia ; Porteboeuf-Houssais, Sarah Julie ; Pospisil, Vladimir ; Potukuchi, Baba ; Prasad, Sidharth Kumar ; Preghenella, Roberto ; Prino, Francesco ; Andre Pruneau, Claude ; Pshenichnov, Igor A. ; Puddu, Giovanna ; Punin, Valery ; Putis, Marian ; Putschke, Jörn H. ; Quercigh, Emanuele ; Qvigstad, Henrik ; Rachevski, Alexandre ; Rademakers, Alphonse ; Samuli Raiha, Tomi ; Rak, Jan ; Malala Rakotozafindrabe, Andry ; Ramello, Luciano ; Ramirez Reyes, Abdiel ; Raniwala, Rashmi ; Raniwala, Sudhir ; Sakari Rasanen, Sami ; Theodor Rascanu, Bogdan ; Rathee, Deepika ; Francis Read, Kenneth ; Real, Jean-Sébastien ; Redlich, Krzysztof ; Jan Reed, Rosi ; Ur Rehman, Attiq ; Reichelt, Patrick ; Reicher, Martijn ; Arno Ernst Renfordt, Rainer ; Rita Reolon, Anna ; Reshetin, Andrey ; Vincenz Rettig, Felix ; Revol, Jean-Pierre ; Johannes Reygers, Klaus ; Riccati, Lodovico ; Angelo Ricci, Renato ; Richert, Tuva ; Richter, Matthias ; Riedler, Petra ; Riegler, Werner ; Riggi, Francesco ; Rodrı́guez Cahuantzi, Mario ; Rodriguez Manso, Alis ; Roed, Ketil ; Rohr, David ; Röhrich, Dieter ; Romita, Rosa ; Ronchetti, Federico ; Rosnet, Philippe ; Rossegger, Stefan ; Rossi, Andrea ; Sophie Roy, Christelle ; Kumar Roy, Pradip ; Juan Rubio Montero, Antonio ; Rui, Rinaldo ; Russo, Riccardo ; Ryabinkin, Evgeny ; Rybicki, Andrzej ; Sadovskiy, Sergey ; Šafařík, Karel ; Sahoo, Raghunath ; Kumar Sahu, Pradip ; Saini, Jogender ; Sakaguchi, Hiroaki ; Sakai, Shingo ; Sakata, Dosatsu ; Albert Salgado, Carlos ; Salzwedel, Jai ; Singh Sambyal, Sanjeev ; Samsonov, Vladimir ; Sanchez Castro, Xitzel ; Šándor, Ladislav ; Sandoval, Andres ; Sano, Masato ; Santagati, Gianluca ; Santoro, Romualdo ; Jaako Sarkamo, Juho ; Scapparone, Eugenio ; Scarlassara, Fernando ; Paul Scharenberg, Rolf ; Schiaua, Claudiu Cornel ; Schicker, Rainer ; Joachim Schmidt, Christian ; Rudolf Schmidt, Hans ; Schuchmann, Simone ; Schukraft, Jürgen ; Schuster, Tim ; Roland Schutz, Yves ; Eberhard Schwarz, Kilian ; Schweda, Kai ; Scioli, Gilda ; Scomparin, Enrico ; Aaron Scott, Patrick ; Scott, Rebecca ; Segato, Gianfranco ; Selyuzhenkov, Ilya ; Senyukov, Serhiy ; Seo, Jeewon ; Serci, Sergio ; Serradilla, Eulogio ; Sevcenco, Adrian ; Shabetai, Alexandre ; Shabratova, Galina ; Shahoyan, Ruben ; Sharma, Natasha ; Sharma, Satish ; Sharma, Rohini ; Shigaki, Kenta ; Shtejer, Katherin ; Sibiriak, Yury ; Sicking, Eva ; Siddhanta, Sabyasachi ; Siemiarczuk, Teodor ; Olle Rickard Silvermyr, David ; Silvestre, Catherine ; Simatovic, Goran ; Simonetti, Giuseppe ; Narayana Singaraju, Rama ; Singh, Ranbir ; Singha, Subhash ; Singhal, Vikas ; Sinha, Bikash ; Sinha, Tinku ; Sitar, Branislav ; Sitta, Mario ; Skaali, Toralf Bernhard ; Skjerdal, Kyrre ; Smakal, Radek ; Smirnov, Nikolai ; Snellings, Raimond ; Sogaard, Carsten ; Ariel Soltz, Ron ; Son, Hyungsuk ; Song, Jihye ; Song, Myunggeun ; Soos, Csaba ; Soramel, Francesca ; Sputowska, Iwona ; Spyropoulou-Stassinaki, Martha ; Srivastava, Brijesh Kumar ; Stachel, Johanna ; Stan, Ionel ; Stefanek, Grzegorz ; Steinpreis, Matthew ; Anders Stenlund, Evert ; Francois Steyn, Gideon ; Hendrik Stiller, Johannes ; Stocco, Diego ; Stolpovskiy, Mikhail ; Strmen, Peter ; Suaide, Alexandre Alarcon do Passo ; Subieta Vasquez, Martin Alfonso ; Sugitate, Toru ; Suire, Christophe Pierre ; Sultanov, Rishat ; Šumbera, Michal ; Šuša, Tatjana ; Symons, Timothy ; Toledo, Alejandro Szanto de ; Szarka, Imrich ; Szczepankiewicz, Adam ; Krzysztof Szostak, Artur ; Szymanski, Maciej ; Takahashi, Jun ; Tapia Takaki, Jesus Daniel ; Tarantola Peloni, Attilio ; Tarazona Martinez, Alfonso ; Tauro, Arturo ; Tejeda Muñoz, Guillermo ; Telesca, Adriana ; Terrevoli, Cristina ; Mathias Thader, Jochen ; Thomas, Deepa ; Noel Tieulent, Raphael ; Timmins, Anthony Robert ; Tlusty, David ; Toia, Alberica ; Torii, Hisayuki ; Toscano, Luca ; Trubnikov, Victor ; Truesdale, David Christopher ; Trzaska, Wladyslaw Henryk ; Tsuji, Tomoya ; Tumkin, Alexandr ; Turrisi, Rosario ; Spedstad Tveter, Trine ; Glyndwr Ulery, Jason ; Ullaland, Kjetil ; Ulrich, Jochen ; Uras, Antonio ; Urban, Jozef ; Marie Urciuoli, Guido ; Usai, Gianluca ; Vajzer, Michal ; Vala, Martin ; Valencia Palomo, Lizardo ; Vallero, Sara ; Vyvre, Pierre vande ; Leeuwen, Marco van ; Vannucci, Luigi ; Diozcora Vargas, Aurora ; Varma, Raghava ; Vasileiou, Maria ; Vasiliev, Andrey ; Vechernin, Vladimir ; Veldhoen, Misha ; Venaruzzo, Massimo ; Vercellin, Ermanno ; Vergara, Sergio ; Vernet, Renaud ; Verweij, Marta ; Vicković, Linda ; Viesti, Giuseppe ; Viinikainen, Jussi ; Vilakazi, Zabulon ; Villalobos Baillie, Orlando ; Vinogradov, Yury I. ; Vinogradov, Alexander ; Vinogradov, Leonid ; Virgili, Tiziano ; Viyogi, Yogendra P. ; Vodopianov, Alexander ; Voloshin, Sergei ; Voloshin, Kirill ; Volpe, Giacomo ; Haller, Barthélémy von ; Vorobyev, Ivan ; Vranić, Danilo ; Vrláková, Janka ; Vulpescu, Bogdan ; Vyushin, Alexey ; Wagner, Boris ; Wagner, Vladimir ; Wan, Renzhuo ; Wang, Yaping ; Wang, Yifei ; Wang, Mengliang ; Wang, Dong ; Watanabe, Kengo ; Weber, Michael ; Wessels, Johannes ; Westerhoff, Uwe ; Wiechula, Jens ; Wikne, Jon ; Rudolf Wilde, Martin ; Andrzej Wilk, Grzegorz ; Wilk, Alexander ; Williams, M. Crispin S. ; Windelband, Bernd ; Xaplanteris Karampatsos, Leonidas ; Yaldo, Chris G. ; Yamaguchi, Yorito ; Yang, Hongyan ; Yang, Shiming ; Yasnopolsky, Stanislav ; Yi, JunGyu ; Yin, Zhongbao ; Yoo, In-Kwon ; Yoon, Jongik ; Yu, Weilin ; Yuan, Xianbao ; Yushmanov, Igor ; Zaccolo, Valentina ; Zach, Cenek ; Zampolli, Chiara ; Zaporozhets, Sergey ; Zarochentsev, Andrey ; Závada, Petr ; Zaviyalov, Nikolai ; Zbroszczyk, Hanna Paulina ; Zelnicek, Pierre ; Ion Zgura, Sorin ; Zhalov, Mikhail ; Zhang, Haitao ; Zhang, Xiaoming ; Zhou, Fengchu ; Zhou, You ; Zhou, Daicui ; Zhu, Hongsheng ; Zhu, Jianhui ; Zhu, Jianlin ; Zhu, Xiangrong ; Zichichi, Antonino ; Zimmermann, Alice ; Zinovjev, Gennady M. ; Denis Zoccarato, Yannick ; Zynovyev, Mykhaylo ; Zyzak, Maksym
Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p–Pb collisions at a nucleon–nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5<pT,assoc<pT,trig<4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and expressed as associated yield per trigger particle. Two long-range ridge-like structures, one on the near side and one on the away side, are observed when the per-trigger yield obtained in low-multiplicity events is subtracted from the one in high-multiplicity events. The excess on the near-side is qualitatively similar to that recently reported by the CMS Collaboration, while the excess on the away-side is reported for the first time. The two-ridge structure projected onto azimuthal angle is quantified with the second and third Fourier coefficients as well as by near-side and away-side yields and widths. The yields on the near side and on the away side are equal within the uncertainties for all studied event multiplicity and pT bins, and the widths show no significant evolution with event multiplicity or pT. These findings suggest that the near-side ridge is accompanied by an essentially identical away-side ridge.