Refine
Year of publication
Document Type
- Article (150)
- Preprint (38)
- Conference Proceeding (4)
Language
- English (192) (remove)
Has Fulltext
- yes (192)
Is part of the Bibliography
- no (192)
Keywords
- LHC (7)
- breast cancer (7)
- Mammakarzinom (6)
- Behandlung (4)
- Breast cancer (4)
- Metastasen (4)
- ALICE (3)
- ALICE experiment (3)
- CDK4/6 (3)
- Hadron-Hadron Scattering (3)
- PD1/PDL1 (3)
- Prävention (3)
- Studien (3)
- pp collisions (3)
- prevention (3)
- treatment (3)
- Beauty production (2)
- HNSCC (2)
- Head and neck cancer (2)
- Machine learning (2)
- Risiko (2)
- Single electrons (2)
- Surgery (2)
- lapatinib (2)
- metastases (2)
- metastatic (2)
- neoadjuvant therapy (2)
- risk (2)
- trastuzumab (2)
- trials (2)
- 900 GeV (1)
- ATXN2 (1)
- Active middle ear implants (1)
- Advanced breast cancer (1)
- Alpelisib (1)
- Amyotrophic lateral sclerosis (1)
- Antihormone therapy (1)
- Arteria ophthalmica (1)
- Artificial Intelligence (1)
- Atezolizumab (1)
- Atoms (1)
- Auditory system (1)
- B cell malignancies (1)
- BCOR (1)
- BCORL1 (1)
- Bibliometrics (1)
- Biodiversity Data (1)
- Biomarker (1)
- Biomonitoring (1)
- Bipolar disorder (1)
- Blindness (1)
- Bone conduction devices (1)
- Bone metastases (1)
- Botanical Collections (1)
- Brain metastasis (1)
- Business strategy in drug development (1)
- C3M (1)
- C4M (1)
- CD74 (1)
- COVID (1)
- COVID-19 (1)
- CUP (1)
- CVID (1)
- Cancer of unknown primary (1)
- Capecitabine (1)
- Cell membranes (1)
- Cellular microbiology (1)
- Cellular stress (1)
- Central nervous system metastases (1)
- Cervical (1)
- Charm physics (1)
- Chemical biology (1)
- Chemical ecology (1)
- Citation analysis (1)
- Clinical Trials and Observations (1)
- Compact astrophysical objects (1)
- Comparison with QCD (1)
- Completed suicide (1)
- Consensus statement (1)
- Conservation (1)
- Cryoelectron microscopy (1)
- Cryoelectron tomography (1)
- DNA repair (1)
- Diagnostic markers (1)
- Diagnostik (1)
- Digital breast tomosynthesis (DBT) (1)
- Digital mammography (1)
- Digitization (1)
- Drug therapy (1)
- EBV (1)
- Endocrinology (1)
- Environmental chemistry (1)
- Epilepsy (1)
- European Society for Immunodeficiencies (ESID) (1)
- Exosomes (1)
- Extended donor criteria (1)
- FDG-PET/CT (1)
- Femtoscopy (1)
- Filler (1)
- First site of metastatic disease (1)
- Früherkennung (1)
- Galaktografie (1)
- Galaktomosynthese (1)
- Galaxies and clusters (1)
- Gene regulation (1)
- German PID-NET registry (1)
- Glabella (1)
- Global protein synthesis rates (1)
- Guanine nucleotide exchange factors (1)
- Guanosine triphosphatase (1)
- HBT (1)
- HER2 c-erbB2 (1)
- HER2-positive (1)
- HER2/neu (1)
- HLA class II (1)
- HLA peptidome (1)
- Hadron production (1)
- Head neck cancer (1)
- Health policy (1)
- Heavy Ions (1)
- Heavy flavor production (1)
- Heavy flavour production (1)
- Heavy ions (1)
- Heavy-flavour production (1)
- Heavy-ion collisions (1)
- Herbaria (1)
- Heregulin (1)
- High-energy astrophysics (1)
- Iceland (1)
- IgG substitution therapy (1)
- Immunophenotyping (1)
- Immunotherapy (1)
- Inclusive spectra (1)
- Induction therapy (1)
- Intensity interferometry (1)
- Ions (1)
- Isoflurane (1)
- Jets (1)
- KCGS (1)
- Katherine (1)
- Kidney diseases (1)
- LTER (1)
- LTP (1)
- Library screening (1)
- Loco-regional control (1)
- Lokalrezidiv (1)
- Long‐term ecosystem research (1)
- Luciferase (1)
- Lymph node (1)
- Lymphocyte subpopulations (1)
- MM-121 (1)
- MRI (1)
- MRT (1)
- Mamma (1)
- Metastatic (1)
- Metastatic breast cancer (1)
- MicroRNAs (1)
- Mid-rapidity (1)
- Mixed hearing loss (1)
- Molecular subtypes (1)
- Monte Carlo simulations (1)
- Multi-stakeholder approach (1)
- Multi-strange baryons (1)
- Multienzyme complexes (1)
- Myeloid Neoplasia (1)
- NK cell subsets (1)
- NPH insulin (1)
- Nachsorge (1)
- Nanoscale materials (1)
- Neoadjuvant therapy (1)
- Nuclear modification factor (1)
- Occlusion (1)
- Ophthalmoplegia (1)
- Organ allocation (1)
- PARP (1)
- PD1/ PDL1 (1)
- PD‑L1 (1)
- PELICAN (1)
- PI3K (1)
- PID prevalence (1)
- PYTHIA (1)
- Paediatrics (1)
- Pancreas transplantation (1)
- Pandemic (1)
- Pathological complete response (1)
- Patterns of care (1)
- Pb–Pb (1)
- Pegylated liposomal doxorubicin (1)
- Perturbative methods (1)
- Phosphorylation (1)
- Population-based screening (1)
- Prediction of locoregional recurrence (1)
- Prognosefaktoren (1)
- Proton–proton (1)
- Prädiktivfaktoren (1)
- RNA processing (1)
- Radiochemotherapy (1)
- Radiomics (1)
- Radiotherapy (1)
- Recall rate (1)
- Red blood cell transfusion (1)
- Rehabilitation (1)
- Rejection (1)
- Relativistic heavy ion physics (1)
- Research Infrastructure (1)
- Research infrastructure (1)
- Retinal diseases (1)
- Ribosomal S6 phosphorylation (1)
- Ribosomal translation (1)
- Richtlinie (1)
- SARS-CoV2 (1)
- SCCHN (1)
- Salivary gland carcinoma (1)
- Scattering of atoms, molecules, clusters & ions (1)
- Scattering theory (1)
- Scientific publishing (1)
- Scientists (1)
- Semantics (1)
- Seribantumab (1)
- Single muons (1)
- Site networks (1)
- Small molecules (1)
- Spinocerebellar ataxia (1)
- Status epilepticus (1)
- Stem-cell therapies (1)
- Suicide attempt (1)
- Supportivtherapie (1)
- T-DM1 (1)
- TGFB-induced factor homeobox 1 (1)
- TGIF (1)
- Taxonomy (1)
- Technical data (1)
- Tomosynthese (1)
- Transverse momentum (1)
- Triple negative (1)
- Tumor heterogeneity (1)
- Tumor infiltrating lymphocytes (1)
- Type 2 diabetes (1)
- T‑DM1 (1)
- Ultraschall (1)
- Validation (1)
- Vesicles (1)
- accident (1)
- acute myeloid leukemia (1)
- adjuvant therapy (1)
- adjuvante Therapie (1)
- advanced (1)
- advanced breast cancer (1)
- aging (1)
- alpelisib (1)
- amblyopia (1)
- amyloid precursor protein (1)
- anaemia (1)
- anterior chamber depth changes (1)
- antibiotic therapy (1)
- antihormone therapy (1)
- archeological modeling (1)
- artificial magnetic lattices (1)
- ascites (1)
- atezolizumab (1)
- basal insulin (1)
- biomarker (1)
- breast (1)
- cataract surgery (1)
- chemogenomic set (1)
- chemotherapy (1)
- chloroplast membrane proteins (1)
- circadian variation (1)
- collagen degradation marker (1)
- continuous glucose monitoring (1)
- diabetes (1)
- diabetic macular edema (1)
- diagnosis (1)
- diclofenac (1)
- diffusion-weighted magnetic resonance imaging (1)
- drug discovery (1)
- druggable genome (1)
- early breast cancer (1)
- effective lens position (1)
- elderly patients (1)
- envelope membrane proteome approach comparison (1)
- everolimus (1)
- fluocinolone acetonide (1)
- focused electron beam induced deposition (1)
- follow‑up (1)
- fortgeschritten (1)
- frühes Mammakarzinom (1)
- galactography (1)
- galactomosynthesis (1)
- gene signature (1)
- guideline (1)
- head and neck squamous cell carcinoma (1)
- heavy ions (1)
- hippocampus (1)
- human–environment interaction (1)
- hypoglycaemia (1)
- image-based risk modelling (1)
- injury (1)
- iron deficiency (1)
- kinase inhibitor (1)
- liver cirrhosis (1)
- local recurrence (1)
- lockdown (1)
- loss-of-function (1)
- machine learning (1)
- magnetic nanostructures (1)
- mass spectrometry (1)
- membrane proteome (1)
- meta-analysis (1)
- metastasis (1)
- metastatic renal cell carcinoma (1)
- metformin (1)
- micro-Hall magnetometry (1)
- microdosimetry (1)
- microdosing (1)
- micromagnetic simulations (1)
- mitochondria (1)
- multidrug resistance (1)
- multiplexed immunofluorescence (1)
- nanolesions (1)
- neoadjuvant chemoradiotherapy (1)
- neoadjuvante Therapie (1)
- open science (1)
- oral cavity cancer (1)
- oral enzyme combination (1)
- osteoarthritis (1)
- paleoclimate modeling (1)
- paleoenvironment modeling (1)
- paleoenvironment reconstruction (1)
- patient blood management (1)
- pediatric eye screening (1)
- pediatric intensive care (1)
- personalised therapy (1)
- pertuzumab (1)
- phase IV (1)
- phenotypic screening (1)
- plant proteomics (1)
- postoperative radiochemotherapy (1)
- postoperative radiotherapy (1)
- predictive biomarker (1)
- predictive factors (1)
- pregnancy (1)
- preoperative anaemia management (1)
- preschool health examination (1)
- presynaptic active zone (1)
- primary immunodeficiency (PID) (1)
- prognostic factors (1)
- propensity score matching (1)
- protein kinase (1)
- pseudoexfoliative syndrome (1)
- radiation oncology (1)
- radiation-induced nanostructures (1)
- radiomic (1)
- randomized controlled trial (1)
- rat (1)
- registry for primary immunodeficiency (1)
- risk stratification (1)
- screening (1)
- screening routine (1)
- second-line (1)
- small molecules (1)
- spectra (1)
- studies (1)
- supportive therapy (1)
- surgery (1)
- survival (1)
- tomosynthesis (1)
- trauma (1)
- treatment/therapy (1)
- ultrasound (1)
- understudied kinase (1)
- √sN N = 2.76 TeV (1)
Institute
- Physik (93)
- Medizin (71)
- Frankfurt Institute for Advanced Studies (FIAS) (70)
- Informatik (69)
- Geowissenschaften (11)
- Biowissenschaften (9)
- Biochemie und Chemie (7)
- Pharmazie (3)
- ELEMENTS (2)
- Exzellenzcluster Makromolekulare Komplexe (2)
In psychiatry, there has been a growing focus on identifying at-risk populations. For schizophrenia, these efforts have led to the development of early recognition and intervention measures. Despite a similar disease burden, the populations at risk of bipolar disorder have not been sufficiently characterized. Within the BipoLife consortium, we used magnetic resonance imaging (MRI) data from a multicenter study to assess structural gray matter alterations in N = 263 help-seeking individuals from seven study sites. We defined the risk using the EPIbipolar assessment tool as no-risk, low-risk, and high-risk and used a region-of-interest approach (ROI) based on the results of two large-scale multicenter studies of bipolar disorder by the ENIGMA working group. We detected significant differences in the thickness of the left pars opercularis (Cohen’s d = 0.47, p = 0.024) between groups. The cortex was significantly thinner in high-risk individuals compared to those in the no-risk group (p = 0.011). We detected no differences in the hippocampal volume. Exploratory analyses revealed no significant differences in other cortical or subcortical regions. The thinner cortex in help-seeking individuals at risk of bipolar disorder is in line with previous findings in patients with the established disorder and corresponds to the region of the highest effect size in the ENIGMA study of cortical alterations. Structural alterations in prefrontal cortex might be a trait marker of bipolar risk. This is the largest structural MRI study of help-seeking individuals at increased risk of bipolar disorder.
Nowadays, several options are available to treat patients with conductive or mixed hearing loss. Whenever surgical intervention is not possible or contra-indicated, and amplification by a conventional hearing device (e.g., behind-the-ear device) is not feasible, then implantable hearing devices are an indispensable next option. Implantable bone-conduction devices and middle-ear implants have advantages but also limitations concerning complexity/invasiveness of the surgery, medical complications, and effectiveness. To counsel the patient, the clinician should have a good overview of the options with regard to safety and reliability as well as unequivocal technical performance data. The present consensus document is the outcome of an extensive iterative process including ENT specialists, audiologists, health-policy scientists, and representatives/technicians of the main companies in this field. This document should provide a first framework for procedures and technical characterization to enhance effective communication between these stakeholders, improving health care.
Mutations of the isocitrate dehydrogenase-1 (IDH1) and IDH2 genes are among the most frequent alterations in acute myeloid leukemia (AML) and can be found in ∼20% of patients at diagnosis. Among 4930 patients (median age, 56 years; interquartile range, 45-66) with newly diagnosed, intensively treated AML, we identified IDH1 mutations in 423 (8.6%) and IDH2 mutations in 575 (11.7%). Overall, there were no differences in response rates or survival for patients with mutations in IDH1 or IDH2 compared with patients without mutated IDH1/2. However, distinct clinical and comutational phenotypes of the most common subtypes of IDH1/2 mutations could be associated with differences in outcome. IDH1-R132C was associated with increased age, lower white blood cell (WBC) count, less frequent comutation of NPM1 and FLT3 internal tandem mutation (ITD) as well as with lower rate of complete remission and a trend toward reduced overall survival (OS) compared with other IDH1 mutation variants and wild-type (WT) IDH1/2. In our analysis, IDH2-R172K was associated with significantly lower WBC count, more karyotype abnormalities, and less frequent comutations of NPM1 and/or FLT3-ITD. Among patients within the European LeukemiaNet 2017 intermediate- and adverse-risk groups, relapse-free survival and OS were significantly better for those with IDH2-R172K compared with WT IDH, providing evidence that AML with IDH2-R172K could be a distinct entity with a specific comutation pattern and favorable outcome. In summary, the presented data from a large cohort of patients with IDH1/2 mutated AML indicate novel and clinically relevant findings for the most common IDH mutation subtypes.
(1) Background: Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) who are biologically at high risk for the development of loco–regional recurrences after postoperative radiotherapy (PORT) but at intermediate risk according to clinical risk factors may benefit from additional concurrent chemotherapy. In this matched-pair study, we aimed to identify a corresponding predictive gene signature. (2) Methods: Gene expression analysis was performed on a multicenter retrospective cohort of 221 patients that were treated with postoperative radiochemotherapy (PORT-C) and 283 patients who were treated with PORT alone. Propensity score analysis was used to identify matched patient pairs from both cohorts. From differential gene expression analysis and Cox regression, a predictive gene signature was identified. (3) Results: 108 matched patient pairs were selected. We identified a 2-metagene signature that stratified patients into risk groups in both cohorts. The comparison of the high-risk patients between the two types of treatment showed higher loco–regional control (LRC) after treatment with PORT-C (p < 0.001), which was confirmed by a significant interaction term in Cox regression (p = 0.027), i.e., the 2-metagene signature was indicative for the type of treatment. (4) Conclusion: We have identified a novel gene signature that may be helpful to identify patients with high-risk HNSCC amongst those at intermediate clinical risk treated with PORT, who may benefit from additional concurrent chemotherapy.
Purpose: Filler injections for aesthetic purposes are very popular, but can have far-reaching and irreversible consequences. This report describes the course of a patient with devastating complications after glabellar hyaluronic acid injection, their pathomechanism, management and outcome.
Observations: A healthy, 43-year-old woman underwent her first hyaluronic acid injection in the glabella and went blind on her left eye immediately thereafter. Massaging of the injection area and observation were performed, before she presented with swelling of the left forehead and upper lid, ptosis, complete ophthalmoplegia and blindness in our hospital. Immediate massaging of the globe and systemic therapy including acetylsalicylic acid, tinzaparin sodium and cortisone was initiated and hyaluronidase injections in the injection area were performed. In the further course, the patient developed necrotic and hemorrhagic skin and mucosal lesions, lagophthalmos, anterior and posterior segment ischemia and globe hypotonia with consecutive globe deformation. In the follow-up of 2.5 months, lid swelling, lagophthalmos and ptosis resolved and keratopathy improved but blindness, skin lesions and strabismus with reduced eye motility were still present and madarosis and early enophthalmos were detected.
Conclusions and Importance: The outcome of ophthalmic artery occlusion after hyaluronic acid filler injection is poor. Sufficient knowledge about facial anatomy, the implementation of filler injections and the management of complications is essential for the practitioner. The patient should be clarified about potential and even rare risks of these procedures.
The consequences of the current COVID-19 pandemic for mental health remain unclear, especially regarding the effects on suicidal behaviors. To assess changes in the pattern of suicide attempt (SA) admissions and completed suicides (CS) in association with the COVID-19 pandemic. As part of a longitudinal study, SA admissions and CS are systematically documented and analyzed in all psychiatric hospitals in Frankfurt/Main (765.000 inhabitants). Number, sociodemographic factors, diagnoses and methods of SA and CS were compared between the periods of March–December 2019 and March–December 2020. The number of CS did not change, while the number of SA significantly decreased. Age, sex, occupational status, and psychiatric diagnoses did not change in SA, whereas the percentage of patients living alone while attempting suicide increased. The rate and number of intoxications as a SA method increased and more people attempted suicide in their own home, which was not observed in CS. Such a shift from public places to home is supported by the weekday of SA, as the rate of SA on weekends was significantly lower during the pandemic, likely because of lockdown measures. Only admissions to psychiatric hospitals were recorded, but not to other institutions. As it seems unlikely that the number of SA decreased while the number of CS remained unchanged, it is conceivable that the number of unreported SA cases increased during the pandemic. Our data suggest that a higher number of SA remained unnoticed during the pandemic because of their location and the use of methods associated with lower lethality.
Background: To study neoadjuvant chemoradiotherapy (nCRT) and potential predictive factors for response in locally advanced oral cavity cancer (LA-OCC).
Methods: The INVERT trial is an ongoing single-center, prospective phase 2, proof-of-principle trial. Operable patients with stage III-IVA squamous cell carcinomas of the oral cavity were eligible and received nCRT consisting of 60 Gy with concomitant cisplatin and 5-fluorouracil. Surgery was scheduled 6-8 weeks after completion of nCRT. Explorative, multiplex immunohistochemistry (IHC) was performed on pretreatment tumor specimen, and diffusion-weighted magnetic resonance imaging (DW-MRI) was conducted prior to, during nCRT (day 15), and before surgery to identify potential predictive biomarkers and imaging features. Primary endpoint was the pathological complete response (pCR) rate.
Results: Seventeen patients with stage IVA OCC were included in this interim analysis. All patients completed nCRT. One patient died from pneumonia 10 weeks after nCRT before surgery. Complete tumor resection (R0) was achieved in 16/17 patients, of whom 7 (41%, 95% CI: 18-67%) showed pCR. According to the Clavien-Dindo classification, grade 3a and 3b complications were found in 4 (25%) and 5 (31%) patients, respectively; grade 4-5 complications did not occur. Increased changes in the apparent diffusion coefficient signal intensities between MRI at day 15 of nCRT and before surgery were associated with better response (p=0.022). Higher abundances of programmed cell death protein 1 (PD1) positive cytotoxic T-cells (p=0.012), PD1+ macrophages (p=0.046), and cancer-associated fibroblasts (CAFs, p=0.036) were associated with incomplete response to nCRT.
Conclusion: nCRT for LA-OCC followed by radical surgery is feasible and shows high response rates. Larger patient cohorts from randomized trials are needed to further investigate nCRT and predictive biomarkers such as changes in DW-MRI signal intensities, tumor infiltrating immune cells, and CAFs.
Children’s and adolescents’ lives drastically changed during COVID lockdowns worldwide. To compare accident- and injury-related admissions to pediatric intensive care units (PICU) during the first German COVID lockdown with previous years, we conducted a retrospective multicenter study among 37 PICUs (21.5% of German PICU capacities). A total of 1444 admissions after accidents or injuries during the first lockdown period and matched periods of 2017–2019 were reported and standardized morbidity ratios (SMR) were calculated. Total PICU admissions due to accidents/injuries declined from an average of 366 to 346 (SMR 0.95 (CI 0.85–1.05)). Admissions with trauma increased from 196 to 212 (1.07 (0.93–1.23). Traffic accidents and school/kindergarten accidents decreased (0.77 (0.57–1.02 and 0.26 (0.05–0.75)), whereas household and leisure accidents increased (1.33 (1.06–1.66) and 1.34 (1.06–1.67)). Less neurosurgeries and more visceral surgeries were performed (0.69 (0.38–1.16) and 2.09 (1.19–3.39)). Non-accidental non-suicidal injuries declined (0.73 (0.42–1.17)). Suicide attempts increased in adolescent boys (1.38 (0.51–3.02)), but decreased in adolescent girls (0.56 (0.32–0.79)). In summary, changed trauma mechanisms entailed different surgeries compared to previous years. We found no evidence for an increase in child abuse cases requiring intensive care. The increase in suicide attempts among boys demands investigation.
Filamentous enzymes have been found in all domains of life, but the advantage of filamentation is often elusive1. Some anaerobic, autotrophic bacteria have an unusual filamentous enzyme for CO2 fixation—hydrogen-dependent CO2 reductase (HDCR)2,3—which directly converts H2 and CO2 into formic acid. HDCR reduces CO2 with a higher activity than any other known biological or chemical catalyst4,5, and it has therefore gained considerable interest in two areas of global relevance: hydrogen storage and combating climate change by capturing atmospheric CO2. However, the mechanistic basis of the high catalytic turnover rate of HDCR has remained unknown. Here we use cryo-electron microscopy to reveal the structure of a short HDCR filament from the acetogenic bacterium Thermoanaerobacter kivui. The minimum repeating unit is a hexamer that consists of a formate dehydrogenase (FdhF) and two hydrogenases (HydA2) bound around a central core of hydrogenase Fe-S subunits, one HycB3 and two HycB4. These small bacterial polyferredoxin-like proteins oligomerize through their C-terminal helices to form the backbone of the filament. By combining structure-directed mutagenesis with enzymatic analysis, we show that filamentation and rapid electron transfer through the filament enhance the activity of HDCR. To investigate the structure of HDCR in situ, we imaged T. kivui cells with cryo-electron tomography and found that HDCR filaments bundle into large ring-shaped superstructures attached to the plasma membrane. This supramolecular organization may further enhance the stability and connectivity of HDCR to form a specialized metabolic subcompartment within the cell.
Aim: In the CheckRad-CD8 trial patients with locally advanced head and neck squamous cell cancer are treated with a single cycle of induction chemo-immunotherapy (ICIT). Patients with pathological complete response (pCR) in the re-biopsy enter radioimmunotherapy. Our goal was to study the value of F-18-FDG PET/CT in the prediction of pCR after induction therapy.
Methods: Patients treated within the CheckRad-CD8 trial that additionally received FDG- PET/CT imaging at the following two time points were included: 3–14 days before (pre-ICIT) and 21–28 days after (post-ICIT) receiving ICIT. Tracer uptake in primary tumors (PT) and suspicious cervical lymph nodes (LN +) was measured using different quantitative parameters on EANM Research Ltd (EARL) accredited PET reconstructions. In addition, mean FDG uptake levels in lymphatic and hematopoietic organs were examined. Percent decrease (Δ) in FDG uptake was calculated for all parameters. Biopsy of the PT post-ICIT acquired after FDG-PET/CT served as reference. The cohort was divided in patients with pCR and residual tumor (ReTu).
Results: Thirty-one patients were included. In ROC analysis, ΔSUVmax PT performed best (AUC = 0.89) in predicting pCR (n = 17), with a decline of at least 60% (sensitivity, 0.77; specificity, 0.93). Residual SUVmax PT post-ICIT performed best in predicting ReTu (n = 14), at a cutpoint of 6.0 (AUC = 0.91; sensitivity, 0.86; specificity, 0.88). Combining two quantitative parameters (ΔSUVmax ≥ 50% and SUVmax PT post-ICIT ≤ 6.0) conferred a sensitivity of 0.81 and a specificity of 0.93 for determining pCR. Background activity in lymphatic organs or uptake in suspected cervical lymph node metastases lacked significant predictive value.
Conclusion: FDG-PET/CT can identify patients with pCR after ICIT via residual FDG uptake levels in primary tumors and the related changes compared to baseline. FDG-uptake in LN + had no predictive value.
Trial registry: ClinicalTrials.gov identifier: NCT03426657.