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Transverse momentum spectra of π±, K± and p(p¯) up to pT = 20 GeV/c at mid-rapidity in pp and Pb-Pb collisions at sNN−−−√= 2.76 TeV have been measured using the ALICE detector at the Large Hadron Collider. The proton-to-pion and the kaon-to-pion ratios both show a distinct peak at pT≈3GeV/c in central Pb-Pb collisions. Below the peak, pT < 3 GeV/c, both ratios are in good agreement with hydrodynamical calculations, suggesting that the peak itself is dominantly the result of radial flow rather than anomalous hadronization processes. For pT > 10 GeV/c particle ratios in pp and Pb-Pb collisions are in agreement and the nuclear modification factors for π±, K± and p(p¯) indicate that, within the systematic and statistical uncertainties, the suppression is the same. This suggests that the chemical composition of leading particles from jets in the medium is similar to that of vacuum jets.
The pT-differential production cross section of electrons from semileptonic decays of heavy-flavor hadrons has been measured at mid-rapidity in proton-proton collisions at s√=2.76 TeV in the transverse momentum range 0.5 < pT < 12 GeV/c with the ALICE detector at the LHC. The analysis was performed using minimum bias events and events triggered by the electromagnetic calorimeter. Predictions from perturbative QCD calculations agree with the data within the theoretical and experimental uncertainties.
The pT-differential production cross section of electrons from semileptonic decays of heavy-flavor hadrons has been measured at mid-rapidity in proton-proton collisions at s√=2.76 TeV in the transverse momentum range 0.5 < pT < 12 GeV/c with the ALICE detector at the LHC. The analysis was performed using minimum bias events and events triggered by the electromagnetic calorimeter. Predictions from perturbative QCD calculations agree with the data within the theoretical and experimental uncertainties.
An experiment addressing electron capture (EC) decay of hydrogen-like 142Pm60+ions has been conducted at the experimental storage ring (ESR) at GSI. The decay appears to be purely exponential and no modulations were observed. Decay times for about 9000 individual EC decays have been measured by applying the single-ion decay spectroscopy method. Both visually and automatically analysed data can be described by a single exponential decay with decay constants of 0.0126(7)s−1 for automatic analysis and 0.0141(7)s−1 for manual analysis. If a modulation superimposed on the exponential decay curve is assumed, the best fit gives a modulation amplitude of merely 0.019(15), which is compatible with zero and by 4.9 standard deviations smaller than in the original observation which had an amplitude of 0.23(4).
Stimulation of renal collecting duct principal cells with antidiuretic hormone (arginine-vasopressin, AVP) results in inhibition of the small GTPase RhoA and the enrichment of the water channel aquaporin-2 (AQP2) in the plasma membrane. The membrane insertion facilitates water reabsorption from primary urine and fine-tuning of body water homeostasis. Rho guanine nucleotide exchange factors (GEFs) interact with RhoA, catalyze the exchange of GDP for GTP and thereby activate the GTPase. However, GEFs involved in the control of AQP2 in renal principal cells are unknown. The A-kinase anchoring protein, AKAP-Lbc, possesses GEF activity, specifically activates RhoA, and is expressed in primary renal inner medullary collecting duct principal (IMCD) cells. Through screening of 18,431 small molecules and synthesis of a focused library around one of the hits, we identified an inhibitor of the interaction of AKAP-Lbc and RhoA. This molecule, Scaff10-8, bound to RhoA, inhibited the AKAP-Lbc-mediated RhoA activation but did not interfere with RhoA activation through other GEFs or activities of other members of the Rho family of small GTPases, Rac1 and Cdc42. Scaff10-8 promoted the redistribution of AQP2 from intracellular vesicles to the periphery of IMCD cells. Thus, our data demonstrate an involvement of AKAP-Lbc-mediated RhoA activation in the control of AQP2 trafficking.
The aim of the present study was to test the influence of picture composition on the narrative complexity of preschool children, and to compare the different procedures of the Cat Story of Hickmann (2002) and the Fox Story of Gülzow & Gagarina (2007) with the Baby Birds and Baby Goats Story of MAIN, by Gagarina et al. (2012). For this purpose, 27 children between the ages of 5;01 and 6;09 were tested with both variants to check whether a macro-structurally controlled picture structure would lead to more complex stories. The results show that narratives with a Goal-Attempt-Outcome structure, i.e. the Baby Birds and Baby Goats Stories, make children with increasing age tell more complex stories by means of a rise in story complexity than the narratives of Hickmann and Gülzow & Gagarina without that structure.
Der Einsatz von Künstliche Intelligenz (KI) – Technologien eröffnet viele Chancen, birgt aber auch viele Risiken – insbesondere in der Finanzbranche. Dieses Whitepaper gibt einen Überblick über den aktuellen Stand der Anwendung und Regulierung von KI-Technologien in der Finanzbranche, und diskutiert Chancen und Risiken von KI. KI findet in der Finanzbranche zahlreiche Anwendungsgebiete. Dazu gehören Chatbots, intelligente Assistenten für Kunden, automatischer Hochfrequenzhandel, automatisierte Betrugserkennung, Überwachung der Compliance, Gesichtserkennungssoftware zur Kundenidentifikation u. v. m. Auch Finanzaufsichtsbehörden setzen zunehmend KI-Anwendungen ein, um große und komplexe Datenmengen (Big Data) automatisiert und skalierbar auf Muster zu untersuchen und ihren Aufsichtspflichten nachzukommen.
Die Regulierung von KI in der Finanzbranche ist ein Balanceakt. Auf der einen Seite gibt es eine Notwendigkeit Flexibilität zu gewährleisten, um Innovationen nicht einzudämmen und im internationalen Wettbewerb nicht abgehängt zu werden. Strenge Auflagen können in diesem Zusammenhang als Barriere für die erfolgreiche Weiter-)Entwicklung von KI-Applikationen in der Finanzbranche wirken. Auf der anderen Seite müssen Persönlichkeitsrechte geschützt und Entscheidungsprozesse nachvollziehbar bleiben. Die fehlende Erklärbarkeit und Interpretierbarkeit von KI-Modellen entsteht in erster Linie durch Intransparenz bei einem Großteil heutiger KI-Anwendungen, bei welchen zwar die Natur der Ein- und Ausgaben beobachtbar und verständlich ist, nicht jedoch die genauen Verarbeitungsschritte dazwischen (Blackbox Prinzip).
Dieses Spannungsfeld zeigt sich auch im aktuellen regulatorischen Ansatz verschiedener Behörden. So werden einerseits die positiven Seiten von KI betont, wie Effizienz- und Effektivitätsgewinne sowie Rentabilitäts- und Qualitätssteigerungen (Bundesregierung, 2019) oder neue Methoden der Gefahrenanalyse in der Finanzmarktregulierung (BaFin, 2018a). Andererseits, wird darauf verwiesen, dass durch KI getroffene Entscheidungen immer von Menschen verantwortet werden müssen (EU Art. 22 DSGVO) und demokratische Rahmenbedingungen des Rechtsstaats zu wahren seien (FinTechRat, 2017).
Für die Zukunft sehen wir die Notwendigkeit internationale Regularien prinzipienbasiert, vereinheitlicht und technologieneutral weiterzuentwickeln, ohne dabei die Entwicklung neuer KIbasierter Geschäftsmodelle zu bremsen. Im globalen Wettstreit sollte Europa bei der Regulierung des KI-Einsatzes eine Vorreiterrolle einnehmen und damit seine demokratischen Werte der digitalen Freiheit, Selbstbestimmung und das Recht auf Information weltweit exportieren. Förderprogramme sollten einen stärkeren Fokus auf die Entwicklung nachhaltiger und verantwortungsvoller KI in Banken legen. Dazu zählt insbesondere die (Weiter-)Entwicklung breit einsetzbarer Methoden, die es erlauben, menschen-interpretierbare Erklärungen für erzeugte Ausgaben bereitzustellen und Problemen wie dem Blackbox Prinzip entgegenzuwirken.
Aus Sicht der Unternehmen in der Finanzbranche könnte eine Kooperation mit BigTech-Unternehmen sinnvoll sein, um gemeinsam das Potential der Technologie bestmöglich ausschöpfen zu können. Nützlich wäre auch ein gemeinsames semantisches Metadatenmodell zur Beschreibung der in der Finanzbranche anfallenden Daten. In Zukunft könnten künstliche Intelligenzen Daten aus sozialen Netzwerken berücksichtigen oder Smart Contracts aushandeln. Eine der größten Herausforderungen der Zukunft wird das Anwerben geeigneten Personals darstellen.
A measurement of the transverse momentum spectra of jets in Pb-Pb collisions at sNN−−−√=2.76 TeV is reported. Jets are reconstructed from charged particles using the anti-kT jet algorithm with jet resolution parameters R of 0.2 and 0.3 in pseudo-rapidity |η|<0.5. The transverse momentum pT of charged particles is measured down to 0.15 GeV/c which gives access to the low pT fragments of the jet. Jets found in heavy-ion collisions are corrected event-by-event for average background density and on an inclusive basis (via unfolding) for residual background fluctuations and detector effects. A strong suppression of jet production in central events with respect to peripheral events is observed. The suppression is found to be similar to the suppression of charged hadrons, which suggests that substantial energy is radiated at angles larger than the jet resolution parameter R=0.3 considered in the analysis. The fragmentation bias introduced by selecting jets with a high pT leading particle, which rejects jets with a soft fragmentation pattern, has a similar effect on the jet yield for central and peripheral events. The ratio of jet spectra with R=0.2 and R=0.3 is found to be similar in Pb-Pb and simulated PYTHIA pp events, indicating no strong broadening of the radial jet structure in the reconstructed jets with R<0.3.
Introduction
(2019)
While impulsivity is a basic feature of attention-deficit / hyperactivity disorder (ADHD), no study explored the effect of different components of the Impulsiveness (Imp) and Venturesomeness (Vent) scale (IV7) on psychiatric comorbidities and an ADHD polygenic risk score (PRS). We used the IV7 self-report scale in an adult ADHD sample of 903 patients, 70% suffering from additional comorbid disorders, and in a subsample of 435 genotyped patients. Venturesomeness, unlike immediate Impulsivity, is not specific to ADHD. We consequently analyzed the influence of Imp and Vent also in the context of a PRS on psychiatric comorbidities of ADHD. Vent shows a distinctly different distribution of comorbidities, e.g., less anxiety and depression. PRS showed no effect on different ADHD comorbidities, but correlated with childhood hyperactivity. In a complementary analysis using principal component analysis with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition ADHD criteria, revised NEO Personality Inventory, Imp, Vent, and PRS, we identified three ADHD subtypes. These are an impulsive–neurotic type, an adventurous–hyperactive type with a stronger genetic component, and an anxious–inattentive type. Our study thus suggests the importance of adventurousness and the differential consideration of impulsivity in ADHD. The genetic risk is distributed differently between these subtypes, which underlines the importance of clinically motivated subtyping. Impulsivity subtyping might give insights into the organization of comorbid disorders in ADHD and different genetic background.