Refine
Year of publication
Document Type
- Article (100)
- Preprint (3)
- Working Paper (1)
Has Fulltext
- yes (104)
Is part of the Bibliography
- no (104)
Keywords
- Apomixis (1)
- Atomic and Molecular Physics (1)
- Bremis Wasserschlauch (Utricularia bremii) (1)
- Buchbesprechung (1)
- COVID-19 (1)
- CVID (1)
- Chromosome number (1)
- Cognitive impairment (1)
- Diagnostic differentiation (1)
- Distribution (1)
Institute
- Medizin (9)
- Extern (3)
- Biodiversität und Klima Forschungszentrum (BiK-F) (2)
- Institut für Ökologie, Evolution und Diversität (2)
- Senckenbergische Naturforschende Gesellschaft (2)
- Center for Financial Studies (CFS) (1)
- Georg-Speyer-Haus (1)
- Institute for Monetary and Financial Stability (IMFS) (1)
- Physik (1)
- Sportwissenschaften (1)
Potentilla heptaphylla gehört in Hessen zu den oft verkannten Arten. Durch Herbarbelege bestätigt sind Vorkommen bei Niederkleen, Münzenberg sowie in Nordhessen um Korbach und Waldeck. Für diese Vorkommen konnte die diploide Chromosomenzahl von 2n = 14 bestätigt werden. Ein Vorkommen im Frankfurter Wald ist erloschen. In Nordhessen wurden außerdem tetraploide Pflanzen festgestellt, bei denen es sich eventuell um Bastarde zwischen Potentilla heptaphylla und P. neumanniana handelt.
Alterations in dendritic spine numbers are linked to deficits in learning and memory. While we previously revealed that postsynaptic plasticity-related gene 1 (PRG-1) controls lysophosphatidic acid (LPA) signaling at glutamatergic synapses via presynaptic LPA receptors, we now show that PRG-1 also affects spine density and synaptic plasticity in a cell-autonomous fashion via protein phosphatase 2A (PP2A)/β1-integrin activation. PRG-1 deficiency reduces spine numbers and β1-integrin activation, alters long-term potentiation (LTP), and impairs spatial memory. The intracellular PRG-1 C terminus interacts in an LPA-dependent fashion with PP2A, thus modulating its phosphatase activity at the postsynaptic density. This results in recruitment of adhesome components src, paxillin, and talin to lipid rafts and ultimately in activation of β1-integrins. Consistent with these findings, activation of PP2A with FTY720 rescues defects in spine density and LTP of PRG-1-deficient animals. These results disclose a mechanism by which bioactive lipid signaling via PRG-1 could affect synaptic plasticity and memory formation.
Schriftenschau
(2012)
Schriftenschau
(2009)
Schriftenschau
(2013)
Schriftenschau
(2008)
Schriftenschau
(2006)
Schriftenschau
(2011)