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Two-particle angular correlations are measured in high-multiplicity proton-proton collisions at s√=13 TeV by the ALICE Collaboration. The yields of particle pairs at short-(Δη ∼ 0) and long-range (1.6<|Δη|<1.8) in pseudorapidity are extracted on the near-side (Δφ ∼ 0). They are reported as a function of transverse momentum (pT) in the range 1<pT<4 GeV/c. Furthermore, the event-scale dependence is studied for the first time by requiring the presence of high-pT leading particles and jets for varying pT thresholds. The results demonstrate that the long-range "ridge" yield, possibly related to the collective behavior of the system, is present in events with high-pT processes. The magnitudes of the short- and long-range yields are found to grow with the event scale. The results are compared to EPOS LHC and PYTHIA 8 calculations, with and without string-shoving interactions. It is found that while both models describe the qualitative trends in the data, calculations from EPOS LHC show a better quantitative agreement, in particular for the pT and event-scale dependencies.
Two-particle angular correlations are measured in high-multiplicity proton-proton collisions at s√=13 TeV by the ALICE Collaboration. The yields of particle pairs at short-(Δη ∼ 0) and long-range (1.6<|Δη|<1.8) in pseudorapidity are extracted on the near-side (Δφ ∼ 0). They are reported as a function of transverse momentum (pT) in the range 1<pT<4 GeV/c. Furthermore, the event-scale dependence is studied for the first time by requiring the presence of high-pT leading particles and jets for varying pT thresholds. The results demonstrate that the long-range "ridge" yield, possibly related to the collective behavior of the system, is present in events with high-pT processes. The magnitudes of the short- and long-range yields are found to grow with the event scale. The results are compared to EPOS LHC and PYTHIA 8 calculations, with and without string-shoving interactions. It is found that while both models describe the qualitative trends in the data, calculations from EPOS LHC show a better quantitative agreement, in particular for the pT and event-scale dependencies.
The coherent photoproduction of J/ψ and ψ′ mesons was measured in ultra-peripheral Pb-Pb collisions at a center-of-mass energy sNN−−−√ = 5.02 TeV with the ALICE detector. Charmonia are detected in the central rapidity region for events where the hadronic interactions are strongly suppressed. The J/ψ is reconstructed using the dilepton (l+l−) and proton-antiproton decay channels, while for the ψ′, the dilepton and the l+l−π+π− decay channels are studied. The analysis is based on an event sample corresponding to an integrated luminosity of about 233 μb−1. The results are compared with theoretical models for coherent J/ψ and ψ′ photoproduction. The coherent cross section is found to be in a good agreement with models incorporating moderate nuclear gluon shadowing of about 0.65 at a Bjorken-x of around 6×10−4, such as the EPS09 parametrization, however none of the models is able to fully describe the rapidity dependence of the coherent J/ψ cross section including ALICE measurements at forward rapidity. The ratio of ψ′ to J/ψ coherent photoproduction cross sections was also measured and found to be consistent with the one for photoproduction off protons.
Bromodomain-containing protein 4 (BRD4) is a member of the bromo- and extraterminal (BET) domain-containing family of epigenetic readers which is under intensive investigation as a target for anti-tumor therapy. BRD4 plays a central role in promoting the expression of select subsets of genes including many driven by oncogenic transcription factors and signaling pathways. However, the role of BRD4 and the effects of BET inhibitors in non-transformed cells remain mostly unclear. We demonstrate that BRD4 is required for the maintenance of a basal epithelial phenotype by regulating the expression of epithelial-specific genes including TP63 and Grainy Head-like transcription factor-3 (GRHL3) in non-transformed basal-like mammary epithelial cells. Moreover, BRD4 occupancy correlates with enhancer activity and enhancer RNA (eRNA) transcription. Motif analyses of cell context-specific BRD4-enriched regions predicted the involvement of FOXO transcription factors. Consistently, activation of FOXO1 function via inhibition of EGFR-AKT signaling promoted the expression of TP63 and GRHL3. Moreover, activation of Src kinase signaling and FOXO1 inhibition decreased the expression of FOXO/BRD4 target genes. Together, our findings support a function for BRD4 in promoting basal mammary cell epithelial differentiation, at least in part, by regulating FOXO factor function on enhancers to activate TP63 and GRHL3 expression.