Refine
Year of publication
Document Type
- Article (141)
- Preprint (78)
- Conference Proceeding (1)
Has Fulltext
- yes (220)
Is part of the Bibliography
- no (220)
Keywords
- BESIII (12)
- Branching fraction (9)
- e +-e − Experiments (6)
- Hadronic decays (4)
- Lepton colliders (4)
- Branching fractions (3)
- Charmed mesons (3)
- Charmonium (3)
- Electroweak interaction (3)
- Particle and Resonance Production (3)
- Quarkonium (3)
- e+-e− Experiments (3)
- Bhabha (2)
- Charm Physics (2)
- Charm physics (2)
- Cross section (2)
- Electroweak Interaction (2)
- Exotics (2)
- Initial state radiation (2)
- Leptonic, semileptonic & radiative decays (2)
- Particle decays (2)
- Spectroscopy (2)
- (E-) Recruiting (1)
- Actin (1)
- Activities of daily living (1)
- Angular distribution (1)
- Annihilation (1)
- Anti-kaon–nucleon physics (1)
- Antirheumatic agents (1)
- Anxiety (1)
- Anxiety disorders (1)
- BESIII detector (1)
- BI1361849 (1)
- Baryonic resonances (1)
- CP violation (1)
- CV9202 (1)
- Cardiomyopathy (1)
- Child (1)
- Clinical Trials and Observations (1)
- Clinical trial (1)
- Comparative effectiveness research (1)
- Complex I (1)
- Consensus (1)
- Covariance matrix (1)
- Cross section measurements (1)
- Crystal structure (1)
- D0 and D+ mesons (1)
- Dalitz decay (1)
- Dark photon (1)
- Dark sector (1)
- Dermatomyositis (1)
- Diagnosis (1)
- Dilated cardiomyopathy (1)
- D⁰ meson (1)
- Electromagnetic amplitude (1)
- Electromagnetic form factor (1)
- Electromagnetic form factors (1)
- Electron-pion identification (1)
- Experimental nuclear physics (1)
- Experimental particle physics (1)
- Fibre/foam sandwich radiator (1)
- Flavor changing neutral currents (1)
- Flavor symmetries (1)
- Flavour Physics (1)
- Form factors (1)
- Freezeout (1)
- Graphs (1)
- Hadronic cross section (1)
- Hadrons (1)
- Heart (1)
- Heart transplantation (1)
- Heavy-ion reactions (1)
- High-pressure (1)
- HuR (1)
- Hyperons (1)
- Hypofractionated radiotherapy (1)
- IRES translation (1)
- Immunomonitoring (1)
- Internet-Stellenbörse (1)
- Interpersonal relationships (1)
- Invisible decays (1)
- Ionisation energy loss (1)
- Kaonic nuclei (1)
- Karriere-Website (1)
- Lactic acidosis (1)
- Low energy QCD (1)
- Mena/VASP (1)
- Mental health therapies (1)
- Mitochondrial disorder (1)
- Multi-wire proportional drift chamber (1)
- Multianvil (1)
- Multiple text comprehension (1)
- Muon anomaly (1)
- Myeloid Neoplasia (1)
- Neonatal (1)
- Neural network (1)
- Neutrinos (1)
- Non-small cell lung cancer (1)
- Partial wave analysis (1)
- Particle and resonance production (1)
- Particle phenomena (1)
- Partner Matching (1)
- Patients (1)
- Personalbeschaffung (1)
- Phase (1)
- Pion form factor (1)
- Plausibility (1)
- Polarization (1)
- Prognosis (1)
- Proton (1)
- Psychometrics (1)
- Psychotherapy (1)
- QCD (1)
- Quantum chromodynamics (1)
- Questionnaires (1)
- R value (1)
- Radiative decay (1)
- Rare decays (1)
- Rare-earth borate (1)
- Science text comprehension (1)
- Semi-leptonic decays (1)
- Spectrin (1)
- Strong amplitude (1)
- TR (1)
- Techniques Electromagnetic calorimeters (1)
- Terbium (1)
- Tracking (1)
- Transition radiation detector (1)
- Treatment (1)
- Trigger (1)
- Triple quarkonia (1)
- Vitamin (1)
- Water balance (1)
- Xenon-based gas mixture (1)
- Y (4260) (1)
- Y states (1)
- artifacts (1)
- attention-deficit/hyperactivity disorder (ADHD) (1)
- available water capacity (1)
- bilin-binding photoreceptors (1)
- bortezomib (1)
- caspase-2 (1)
- center-of-mass energy (1)
- charmonium-like states (1)
- chemotherapeutic drug resistance (1)
- colon carcinoma cells (1)
- dE/dx (1)
- data quality (1)
- decay (1)
- dimuon (1)
- diphoton (1)
- drought-stress (1)
- e+e − annihilation (1)
- e+e⁻ − Experiments (1)
- e+e− Experiments (1)
- e+e− annihilation (1)
- electroencephalography (EEG) (1)
- forest site classification (1)
- hadronic events (1)
- inclusive J/ψ decays (1)
- induction regimen (1)
- kidney (1)
- lenalidomide (1)
- luminosity (1)
- mRNA active cancer immunotherapy (1)
- multicenter study (1)
- multiple myeloma (1)
- number of J/ψ events (1)
- photochemistry (1)
- photoisomerization (1)
- ppK − (1)
- renal failure (1)
- site classification system (1)
- time-resolved spectroscopy (1)
- trigger efficiency (1)
- Λ+c baryon (1)
- Σ hyperon (1)
Institute
- Physik (189)
- Medizin (16)
- Geowissenschaften (5)
- Frankfurt Institute for Advanced Studies (FIAS) (3)
- Informatik (3)
- Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit (ZAFES) (3)
- Biochemie und Chemie (2)
- Biodiversität und Klima Forschungszentrum (BiK-F) (2)
- Biowissenschaften (2)
- Psychologie (2)
We present the results of two-pion production in tagged quasi-free np collisions at a deutron incident beam energy of 1.25 GeV/c measured with the High-Acceptance Di-Electron Spectrometer (HADES) installed at GSI. The specific acceptance of HADES allowed for the first time to obtain high-precision data on π+π− and π−π0 production in np collisions in a region corresponding to large transverse momenta of the secondary particles. The obtained differential cross section data provide strong constraints on the production mechanisms and on the various baryon resonance contributions (∆∆, N(1440), N(1520), ∆(1600)). The invariant mass and angular distributions from the np → npπ+π −and np → ppπ−π0 reactions are compared with different theoretical model predictions.
Erstmals wird die Rädertierfauna des 1985 neu entstandenen Kinda-Stausees im Einzugsgebiet des Panlaung-Flusses in Burma (Myanmar) beschrieben und im verbreitungsgeschichtlichen Zusammenhang diskutiert. Die Arbeit ist zugleich die bislang umfassendste Untersuchung von Rotatorien aus dieser tiergeographisch interessanten asiatischen Region. Die Plankton- und Aufwuchsproben wurden auf mehreren Exkursionen 1987-89 gesammelt. Insgesamt konnten 94 monogononte und 5 bdelloide Rädertier-Arten nachgewiesen werden; davon ist Wulfertia kindensis neu für die Wissenschaft. Die überwiegende Zahl der Spezies sind Kosmopoliten.
The adaptive response of Sorghum bicolor landraces from Egypt to drought stress and following recovery was analyzed using two-dimensional difference gel electrophoresis, 2D-DIGE. Physiological measurements and proteome alterations of accession number 11434, drought tolerant, and accession number 11431, drought sensitive, were compared to their relative control values after drought stress and following recovery. Differentially expressed proteins were analysed by Matrix assisted laser desorption ionisation time-of-flight mass spectrometry, MALDI-TOF-MS. Alterations in protein contents related to the energy balance, metabolism (sensu Mewes et al. 1997), and chaperons were the most apparent features to elucidate the differences between the drought tolerant and sensitive accessions. Further alterations in the levels of proteins related to transcription and protein synthesis are discussed.
Objectives: Within a randomized controlled trial contrasting the outcome of manualized cognitive-behavioral (CBT) and short term psychodynamic therapy (PDT) compared to a waiting list condition (the SOPHO-Net trial), we set out to test whether self-reported attachment characteristics change during the treatments and if these changes differ between treatments.
Research design and methods: 495 patients from the SOPHO-Net trial (54.5% female, mean age 35.2 years) who were randomized to either CBT, PDT or waiting list (WL) completed the partner-related revised Experiences in Close Relationships Questionnaire (ECR-R) before and after treatment and at 6 and 12 months follow-up. The Liebowitz Social Anxiety Scale (LSAS) was administered at pre-treatment, post-treatment, and at 6-month and 1-year follow-up. ECR-R scores were first compared to a representative healthy sample (n = 2508) in order to demonstrate that the clinical sample differed significantly from the non-clinical sample with respect to attachment anxiety and avoidance.
Results: LSAS scores correlated significantly with both ECR-R subscales. Post-therapy, patients treated with CBT revealed significant changes in attachment anxiety and avoidance whereas patients treated with PDT showed no significant changes. Changes between post-treatment and the two follow-ups were significant in both conditions, with minimal (insignificant) differences between treatments at the 12- month follow-up.
Conclusions: The current study supports recent reviews of mostly naturalistic studies indicating changes in attachment as a result of psychotherapy. Although there were differences between conditions at the end of treatment, these largely disappeared during the follow-up period which is line with the other results of the SOPHO-NET trial.
Trial registration: Controlled-trials.com ISRCTN53517394
BACKGROUND: In the heart, cytoplasmic actin networks are thought to have important roles in mechanical support, myofibrillogenesis, and ion channel function. However, subcellular localization of cytoplasmic actin isoforms and proteins involved in the modulation of the cytoplasmic actin networks are elusive. Mena and VASP are important regulators of actin dynamics. Due to the lethal phenotype of mice with combined deficiency in Mena and VASP, however, distinct cardiac roles of the proteins remain speculative. In the present study, we analyzed the physiological functions of Mena and VASP in the heart and also investigated the role of the proteins in the organization of cytoplasmic actin networks.
RESULTS: We generated a mouse model, which simultaneously lacks Mena and VASP in the heart. Mena/VASP double-deficiency induced dilated cardiomyopathy and conduction abnormalities. In wild-type mice, Mena and VASP specifically interacted with a distinct αII-Spectrin splice variant (SH3i), which is in cardiomyocytes exclusively localized at Z- and intercalated discs. At Z- and intercalated discs, Mena and β-actin localized to the edges of the sarcomeres, where the thin filaments are anchored. In Mena/VASP double-deficient mice, β-actin networks were disrupted and the integrity of Z- and intercalated discs was markedly impaired.
CONCLUSIONS: Together, our data suggest that Mena, VASP, and αII-Spectrin assemble cardiac multi-protein complexes, which regulate cytoplasmic actin networks. Conversely, Mena/VASP deficiency results in disrupted β-actin assembly, Z- and intercalated disc malformation, and induces dilated cardiomyopathy and conduction abnormalities.
Caspase-2 represents the most conserved member of the caspase family, which exhibits features of both initiator and effector caspases. Using ribonucleoprotein (RNP)-immunoprecipitation assay, we identified the proapoptotic caspase-2L encoding mRNA as a novel target of the ubiquitous RNA-binding protein HuR in DLD-1 colon carcinoma cells. Unexpectedly, crosslinking-RNP and RNA probe pull-down experiments revealed that HuR binds exclusively to the caspase-2-5' untranslated region (UTR) despite that the 3' UTR of the mRNA bears several adenylate- and uridylate-rich elements representing the prototypical HuR binding sites. By using RNAi-mediated loss-of-function approach, we observed that HuR regulates the mRNA and in turn the protein levels of caspase-2 in a negative manner. Silencing of HuR did not affect the stability of caspase-2 mRNA but resulted in an increased redistribution of caspase-2 transcripts from RNP particles to translational active polysomes implicating that HuR exerts a direct repressive effect on caspase-2 translation. Consistently, in vitro translation of a luciferase reporter gene under the control of an upstream caspase-2-5'UTR was strongly impaired after the addition of recombinant HuR, whereas translation of caspase-2 coding region without the 5'UTR is not affected by HuR confirming the functional role of the caspase-2-5'UTR. Functionally, an elevation in caspase-2 level by HuR knockdown correlated with an increased sensitivity of cells to apoptosis induced by staurosporine- and pore-forming toxins as implicated by their significant accumulation in the sub G1 phase and an increase in caspase-2, -3 and poly ADP-ribose polymerase cleavage, respectively. Importantly, HuR knockdown cells remained insensitive toward STS-induced apoptosis if cells were additionally transfected with caspase-2-specific siRNAs. Collectively, our findings support the hypothesis that HuR by acting as an endogenous inhibitor of caspase-2-driven apoptosis may essentially contribute to the antiapoptotic program of adenocarcinoma cells by HuR.
Background: Juvenile dermatomyositis (JDM) is the most common inflammatory myopathy in childhood and a major cause of morbidity among children with pediatric rheumatic diseases. The management of JDM is very heterogeneous. The JDM working group of the Society for Pediatric Rheumatology (GKJR) aims to define consensus- and practice-based strategies in order to harmonize diagnosis, treatment and monitoring of JDM.
Methods: The JDM working group was established in 2015 consisting of 23 pediatric rheumatologists, pediatric neurologists and dermatologists with expertise in the management of JDM. Current practice patterns of management in JDM had previously been identified via an online survey among pediatric rheumatologists and neurologists. Using a consensus process consisting of online surveys and a face-to-face consensus conference statements were defined regarding the diagnosis, treatment and monitoring of JDM. During the conference consensus was achieved via nominal group technique. Voting took place using an electronic audience response system, and at least 80% consensus was required for individual statements.
Results: Overall 10 individual statements were developed, finally reaching a consensus of 92 to 100% regarding (1) establishing a diagnosis, (2) case definitions for the application of the strategies (moderate and severe JDM), (3) initial diagnostic testing, (4) monitoring and documentation, (5) treatment targets within the context of a treat-to-target strategy, (6) supportive therapies, (7) explicit definition of a treat-to-target strategy, (8) various glucocorticoid regimens, including intermittent intravenous methylprednisolone pulse and high-dose oral glucocorticoid therapies with tapering, (9) initial glucocorticoid-sparing therapy and (10) management of refractory disease.
Conclusion: Using a consensus process among JDM experts, statements regarding the management of JDM were defined. These statements and the strategies aid in the management of patients with moderate and severe JDM.
The Transition Radiation Detector (TRD) was designed and built to enhance the capabilities of the ALICE detector at the Large Hadron Collider (LHC). While aimed at providing electron identification and triggering, the TRD also contributes significantly to the track reconstruction and calibration in the central barrel of ALICE. In this paper the design, construction, operation, and performance of this detector are discussed. A pion rejection factor of up to 410 is achieved at a momentum of 1 GeV/c in p-Pb collisions and the resolution at high transverse momentum improves by about 40% when including the TRD information in track reconstruction. The triggering capability is demonstrated both for jet, light nuclei, and electron selection.
The Transition Radiation Detector (TRD) was designed and built to enhance the capabilities of the ALICE detector at the Large Hadron Collider (LHC). While aimed at providing electron identification and triggering, the TRD also contributes significantly to the track reconstruction and calibration in the central barrel of ALICE. In this paper the design, construction, operation, and performance of this detector are discussed. A pion rejection factor of up to 410 is achieved at a momentum of 1 GeV/c in p-Pb collisions and the resolution at high transverse momentum improves by about 40% when including the TRD information in track reconstruction. The triggering capability is demonstrated both for jet, light nuclei, and electron selection.
The Transition Radiation Detector (TRD) was designed and built to enhance the capabilities of the ALICE detector at the Large Hadron Collider (LHC). While aimed at providing electron identification and triggering, the TRD also contributes significantly to the track reconstruction and calibration in the central barrel of ALICE. In this paper the design, construction, operation, and performance of this detector are discussed. A pion rejection factor of up to 410 is achieved at a momentum of 1 GeV/c in p–Pb collisions and the resolution at high transverse momentum improves by about 40% when including the TRD information in track reconstruction. The triggering capability is demonstrated both for jet, light nuclei, and electron selection.