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Anney, Richard ; Klei, Lambertus ; Pinto, Dalila ; Almeida, Joana ; Bacchelli, Elena ; Baird, Gillian ; Bolshakova, Nadia ; Bölte, Sven ; Bolton, Patrick F. ; Bourgeron, Thomas ; Brennan, Sean ; Brian, Jessica ; Casey, Jillian ; Conroy, Judith ; Correia, Catarina ; Corsello, Christina ; Crawford, Emily L. ; Jonge, Maretha de ; Delorme, Richard ; Duketis, Eftichia ; Duque, Frederico ; Estes, Annette ; Farrar, Penny ; Fernandez, Bridget A. ; Folstein, Susan E. ; Fombonne, Eric ; Gilbert, John ; Gillberg, Christopher ; Glessner, Joseph T. ; Green, Andrew ; Green, Jonathan ; Guter, Stephen J. ; Heron, Elizabeth A. ; Holt, Richard ; Howe, Jennifer L. ; Hughes, Gillian ; Hus, Vanessa ; Igliozzi, Roberta ; Jacob, Suma ; Kenny, Graham P. ; Kim, Cecilia ; Kolevzon, Alexander ; Kustanovich, Vlad ; Lajonchere, Clara M. ; Lamb, Janine A. ; Law-Smith, Miriam ; Leboyer, Marion ; Le Couteur, Ann ; Leventhal, Bennett L. ; Liu, Xiao-Qing ; Lombard, Frances ; Lord, Catherine ; Lotspeich, Linda ; Lotspeich, Linda ; Lund, Sabata C. ; Magalhães, Tiago R. ; Mantoulan, Carine ; McDougle, Christopher J. ; Melhem, Nadine M. ; Merikangas, Alison ; Minshew, Nancy J. ; Mirza, Ghazala K. ; Munson, Jeff ; Noakes, Carolyn ; Nygren, Gudrun ; Papanikolaou, Katerina ; Pagnamenta, Alistair T. ; Parrini, Barbara ; Paton, Tara ; Paton, Tara ; Pickles, Andrew ; Posey, David J. ; Poustka, Fritz ; Ragoussis, Jiannis ; Regan, Regina ; Roberts, Wendy ; Roeder, Kathryn ; Roge, Bernadette ; Rutter, Michael L. ; Schlitt, Sabine ; Shah, Naisha ; Sheffield, Val C. ; Soorya, Latha ; Sousa, Inês ; Stoppioni, Vera ; Sykes, Nuala ; Tancredi, Raffaella ; Thompson, Ann P. ; Thomson, Susanne ; Tryfon, Ana ; Tsiantis, John ; Engeland, Herman van ; Vincent, John B. ; Volkmar, Fred ; Vorstman, JAS ; Wallace, Simon ; Wing, Kirsty ; Wittemeyer, Kerstin ; Wood, Shawn ; Zurawiecki, Danielle ; Zwaigenbaum, Lonnie ; Bailey, Anthony J. ; Battaglia, Agatino ; Cantor, Rita M. ; Coon, Hilary ; Cuccaro, Michael L. ; Dawson, Geraldine ; Ennis, Sean ; Freitag, Christine M. ; Geschwind, Daniel H. ; Haines, Jonathan L. ; Klauck, Sabine M. ; McMahon, William M. ; Maestrini, Elena ; Miller, Judith ; Monaco, Anthony P. ; Nelson, Stanley F. ; Nurnberger, John I. ; Oliveira, Guiomar ; Parr, Jeremy R. ; Pericak-Vance, Margaret Ann ; Piven, Joseph ; Schellenberg, Gerard D. ; Scherer, Stephen W. ; Vicente, Astrid M. ; Wassink, Thomas H. ; Wijsman, Ellen M. ; Betancur, Catalina ; Buxbaum, Joseph D. ; Cook, Edwin H. ; Gallagher, Louise ; Gill, Michael ; Hallmayer, Joachim ; Paterson, Andrew D. ; Sutcliffe, James S. ; Szatmari, Peter ; Vieland, Veronica J. ; Hakonarson, Hakon ; Devlin, Bernie
While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stages 1 and 2). In addition to evaluating the association of individual single nucleotide polymorphisms (SNPs), we also sought evidence that common variants, en masse, might affect the risk. Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level. The SNP that achieves the smallest P-value from secondary analyses is rs1718101. It falls in CNTNAP2, a gene previously implicated in susceptibility for ASD. This SNP also shows modest association with age of word/phrase acquisition in ASD subjects, of interest because features of language development are also associated with other variation in CNTNAP2. In contrast, allele scores derived from the transmission of common alleles to Stage 1 cases significantly predict case status in the independent Stage 2 sample. Despite being significant, the variance explained by these allele scores was small (Vm< 1%). Based on results from individual SNPs and their en masse effect on risk, as inferred from the allele score results, it is reasonable to conclude that common variants affect the risk for ASD but their individual effects are modest.
Appelshäuser, Harald ; Bächler, Joachim ; Bailey, Stephen John ; Barnby, Lee Stuart ; Bartke, Jerzy ; Barton, Robert Allan ; Białkowska, Helena ; Billmeier, Anja ; Blyth, Charles O. ; Bock, Rudolf ; Bormann, Christian ; Brady, Franklin Paul ; Brockmann, Robert ; Brun, René ; Bunčić, Predrag ; Caines, Helen Louise ; Cebra, Daniel A. ; Cooper, Glenn E. ; Cramer, John G. ; Csato, Peter ; Dunn, Jason ; Eckardt, Volker ; Eckhardt, Frank ; Ferguson, M. I. ; Fischer, Hans Gerhard ; Flierl, Dominik Bernhard ; Fodor, Zoltan ; Foka, Panagiota ; Freund, Peter ; Friese, Volker ; Fuchs, Matthias ; Gabler, Frank ; Gal, Jozsef ; Gaździcki, Marek ; Gładysz-Dziaduś, Ewa ; Grebieszkow, Jaroslaw ; Günther, Jörg ; Harris, John W. ; Hegyi, Sandor ; Henkel, Torsten ; Hill, L. A. ; Huang, Isaac ; Hümmler, Holm Gero ; Igo, George J. ; Irmscher, Detlef ; Jacobs, Peter Martin ; Jones, Peter Graham ; Kadija, Krešo ; Kolesnikov, Vadim I. ; Kowalski, Marek ; Lasiuk, Brian ; Lévai, Peter ; Malakhov, Aleksandr I. ; Margetis, Spyridon ; Markert, Christina ; Melkumov, Georgy L. ; Mock, Andreas ; Molnár, József ; Nelson, John M. ; Oldenburg, Markus D. ; Odyniec, Grazyna Janina ; Palla, Gabriella ; Panagiotou, Apostolos D. ; Petridis, Athanasios ; Piper, Andreas ; Porter, R. Jefferson ; Poskanzer, Arthur M. ; Poziombka, Stefan ; Prindle, Duncan J. ; Pühlhofer, Falk ; Rauch, Wolfgang Hans ; Reid, Jeffrey G. ; Renfordt, Rainer Arno Ernst ; Retyk, Waldemar ; Ritter, Hans Georg ; Röhrich, Dieter ; Roland, Christof ; Roland, Gunther ; Rudolph, Heinrich ; Rybicki, Andrzej ; Sandoval, Andres ; Sann, Hans ; Semenov, Alexei Yu. ; Schäfer, Erich ; Schmischke, Dirk ; Schmitz, Norbert ; Schönfelder, Stefan ; Seyboth, Peter ; Seyerlein, Jürgen ; Sikler, Ferenc ; Skrzypczak, Ewa ; Squier, Gordon Thomas Anderson ; Stock, Reinhard ; Ströbele, Herbert ; Szentpetery, Imre ; Sziklay, Janos ; Toy, Milton Y. ; Trainor, Thomas A. ; Trentalage, Stephen ; Ullrich, Thomas ; Vassiliou, Maria ; Vesztergombi, György ; Voloshin, Sergei ; Vranić, Danilo ; Wang, Feipeng ; Weerasundara, Dhammika D. ; Wenig, Siegfried ; Whitten, Charles A. ; Wienold, Thomas ; Wood, Lindsay ; Yates, Tim A. ; Xu, Nu ; Zimanyi, Jozsef ; Zhu, Xue-Zhou ; Zybert, Ryszard
Two-particle correlation functions of negative hadrons over wide phase space, and transverse mass spectra of negative hadrons and deuterons near mid-rapidity have been measured in central Pb+Pb collisions at 158 GeV per nucleon by the NA49 experiment at the CERN SPS. A novel Coulomb correction procedure for the negative two-particle correlations is employed making use of the measured oppositely charged particle correlation. Within an expanding source scenario these results are used to extract the dynamic characteristics of the hadronic source, resolving the ambiguities between the temperature and transverse expansion velocity of the source, that are unavoidable when single and two particle spectra are analysed separately. The source shape, the total duration of the source expansion, the duration of particle emission, the freeze-out temperature and the longitudinal and transverse expansion velocities are deduced.
Appelshäuser, Harald ; Bächler, Joachim ; Bailey, Stephen John ; Barna, Daniel ; Barnby, Lee Stuart ; Bartke, Jerzy ; Barton, Robert Allan ; Białkowska, Helena ; Billmeier, Anja ; Blyth, Charles O. ; Bock, Rudolf ; Bormann, Christian ; Brady, Franklin Paul ; Brockmann, Robert ; Brun, René ; Bunčić, Predrag ; Caines, Helen Louise ; Carr, Lincoln D. ; Cebra, Daniel A. ; Cooper, Glenn E. ; Cramer, John G. ; Cristinziani, Markus ; Csató, Péter ; Dunn, Jason ; Eckardt, Volker ; Eckhardt, Frank ; Ferguson, M. I. ; Fischer, Hans Gerhard ; Flierl, Dominik Bernhard ; Fodor, Zoltán ; Foka, Panagiota ; Freund, Peter ; Friese, Volker ; Fuchs, Matthias ; Gabler, Frank ; Ganz, Rudolf ; Geist, W. ; Gál, József ; Gaździcki, Marek ; Gładysz-Dziaduś, Ewa ; Grebieszkow, Jaroslaw ; Günther, Jörg ; Harris, John William ; Hegyi, Sándor ; Henkel, Torsten ; Hill, L. A. ; Hümmler, Holm Gero ; Igo, George J. ; Irmscher, Detlef ; Jacobs, Peter Martin ; Jones, Peter Graham ; Kadija, Krešo ; Kolesnikov, Vadim I. ; Konashenok, Anton ; Kowalski, Marek ; Lasiuk, Brian ; Lévai, Péter ; Liu, F. ; Malakhov, Aleksandr I. ; Margetis, Spyridon ; Markert, Christina ; Melkumov, Georgy L. ; Mock, Andreas ; Molnár, József ; Nelson, J. M. ; Oldenburg, Markus D. ; Odyniec, Grazyna Janina ; Pálla, Gabriella ; Panagiotou, Apostolos D. ; Petridis, Athanasios ; Piper, Andreas ; Porter, R. Jefferson ; Poskanzer, Arthur M. ; Prindle, Duncan J. ; Pühlhofer, Falk ; Rauch, Wolfgang Hans ; Reid, Jeffrey G. ; Renfordt, Rainer Arno Ernst ; Retyk, Waldemar ; Ritter, Hans Georg ; Röhrich, Dieter ; Roland, Christof ; Roland, Gunther ; Rudolph, Heinrich ; Rybicki, Andrzej ; Sandoval, Andres ; Sann, Hans ; Semenov, Alexei Yu. ; Schäfer, Erich ; Schmischke, Dirk ; Schmitz, Norbert ; Schönfelder, Stefan ; Seyboth, Peter ; Seyerlein, Jürgen ; Siklér, Ferenc ; Skrzypczak, Ewa ; Snellings, Raimond ; Squier, Gordon Thomas Anderson ; Stock, Reinhard ; Ströbele, Herbert ; Struck, Christof ; Šuša, Tatjana ; Szentpétery, Imre ; Sziklai, János ; Toy, Milton Y. ; Trainor, Thomas A. ; Trentalange, Stephen ; Ullrich, Thomas ; Vassiliou, Maria ; Veres, Gábor I. ; Vesztergombi, György ; Vranić, Danilo ; Wang, Feipeng ; Weerasundara, Dhammika D. ; Wenig, Siegfried ; Whitten, Charles A. ; Wienold, Thomas ; Wood, Lindsay ; Xu, Nu ; Yates, Tim A. ; Zimányi, József ; Zhu, Xue-Zhou ; Zybert, Ryszard
We report measurements of Xi and Xi-bar hyperon absolute yields as a function of rapidity in 158 GeV/c Pb+Pb collisions. At midrapidity, dN/dy = 2.29 +/- 0.12 for Xi, and 0.52 +/- 0.05 for Xi-bar, leading to the ratio of Xi-bar/Xi = 0.23 +/- 0.03. Inverse slope parameters fitted to the measured transverse mass spectra are of the order of 300 MeV near mid-rapidity. The estimated total yield of Xi particles in Pb+Pb central interactions amounts to 7.4 +/- 1.0 per collision. Comparison to Xi production in properly scaled p+p reactions at the same energy reveals a dramatic enhancement (about one order of magnitude) of Xi production in Pb+Pb central collisions over elementary hadron interactions.
Appelshäuser, Harald ; Bächler, Joachim ; Bailey, Stephen John ; Barnby, Lee Stuart ; Bartke, Jerzy ; Barton, Robert Allan ; Białkowska, Helena ; Blyth, Charles O. ; Bock, Rudolf ; Bormann, Christian ; Brady, Franklin Paul ; Brockmann, Robert ; Buncic, Nenad ; Bunčić, Predrag ; Caines, Helen Louise ; Cebra, Daniel A. ; Cooper, Glenn E. ; Cramer, John G. ; Csató, Péter ; Dunn, Jason ; Eckardt, Volker ; Eckhardt, Frank ; Ferguson, M. I. ; Fischer, Hans Gerhard ; Flierl, Dominik Bernhard ; Fodor, Zoltán ; Foka, Panagiota ; Freund, Peter ; Friese, Volker ; Fuchs, Matthias ; Gabler, Frank ; Gál, József ; Gaździcki, Marek ; Gładysz-Dziaduś, Ewa ; Grebieszkow, Jaroslaw ; Günther, Jörg ; Harris, John W. ; Hegyi, Sándor ; Henkel, Torsten ; Hill, L. A. ; Huang, Isaac ; Hümmler, Holm Gero ; Igo, George J. ; Irmscher, Detlef ; Jacobs, Peter Martin ; Jones, Peter Graham ; Kadija, Krešo ; Kolesnikov, Vadim I. ; Kowalski, Marek ; Lasiuk, Brian ; Lévai, Péter ; Malakhov, Aleksandr I. ; Margetis, Spyridon ; Markert, Christina ; Melkumov, Georgy L. ; Mock, Andreas ; Molnár, József ; Nelson, John M. ; Odyniec, Grazyna Janina ; Pálla, Gabriella ; Panagiotou, Apostolos D. ; Petridis, Athanasios ; Piper, Andreas ; Porter, R. Jefferson ; Poskanzer, Arthur M. ; Poziombka, Stefan ; Prindle, Duncan J. ; Pühlhofer, Falk ; Rauch, Wolfgang Hans ; Reid, Jeffrey G. ; Renfordt, Rainer Arno Ernst ; Retyk, Waldemar ; Ritter, Hans Georg ; Röhrich, Dieter ; Roland, Christof ; Roland, Gunther ; Rudolph, Heinrich ; Rybicki, Andrzej ; Sandoval, Andres ; Sann, Hans ; Semenov, Alexei Yu. ; Schäfer, Erich ; Schmischke, Dirk ; Schmitz, Norbert ; Schönfelder, Stefan ; Seyboth, Peter ; Seyerlein, Jürgen ; Siklér, Ferenc ; Skrzypczak, Ewa ; Squier, Gordon Thomas Anderson ; Stock, Reinhard ; Ströbele, Herbert ; Szentpétery, Imre ; Sziklay, János ; Toy, Milton Y. ; Trainor, Thomas A. ; Trentalage, Stephen ; Ullrich, Thomas ; Vassiliou, Maria ; Vesztergombi, György ; Voloshin, Sergei ; Vranić, Danilo ; Wang, F. ; Weerasundara, Dhammika D. ; Wenig, Siegfried ; Whitten, Charles A. ; Wienold, Thomas ; Wood, Lindsay ; Yates, Tim A. ; Zimányi, József ; Zybert, Ryszard
The directed and elliptic flow of protons and charged pions has been observed from the semi-central collisions of a 158 GeV/nucleon Pb beam with a Pb target. The rapidity and transverse momentum dependence of the flow has been measured. The directed flow of the pions is opposite to that of the protons but both exhibit negative flow at low pt. The elliptic flow of both is fairly independent of rapidity but rises with pt. PACS numbers: 25.75.-q, 25.75.Ld
Odyniec, Grazyna Janina ; Afanasiev, Sergey V. ; Alber, Thomas ; Appelshäuser, Harald ; Bächler, Joachim ; Bailey, Stephen John ; Barnby, Lee Stuart ; Bartke, Jerzy ; Białkowska, Helena ; Blyth, Charles O. ; Bock, Rudolf ; Bormann, Christian ; Brady, Franklin Paul ; Brockmann, Robert ; Buncic, Nenad ; Bunčić, Predrag ; Caines, Helen Louise ; Cebra, Daniel A. ; Chan, P. ; Cooper, Glenn E. ; Cramer, John G. ; Cramer, Pauline B. ; Csató, Péter ; Dietz, Oliver ; Dunn, Jason ; Eckardt, Volker ; Eckhardt, Frank ; Ferguson, M. I. ; Fischer, Hans Gerhard ; Flierl, Dominik Bernhard ; Fodor, Zoltán ; Foka, Panagiota ; Freund, Peter ; Friese, Volker ; Fuchs, M. ; Gabler, Frank ; Gál, József ; Gaździcki, Marek ; Gładysz-Dziaduś, Ewa ; Grebieszkow, Jaroslaw ; Günther, Jörg ; Harris, John W. ; Hegyi, Sándor ; Henkel, Torsten ; Hill, L. A. ; Huang, Isaac ; Howe, Mark A. ; Hümmler, Holm Gero ; Igo, George J. ; Irmscher, Detlef ; Jacobs, Peter Martin ; Jones, Peter Graham ; Kadija, Krešo ; Kolesnikov, Vadim I. ; Konashenok, Anton ; Kowalski, Marek ; Lasiuk, Brian ; Lévai, Péter ; Malakhov, Aleksandr I. ; Margetis, Spyridon ; Markert, Christina ; Melkumov, Georgy L. ; Mock, Andreas ; Molnár, József ; Nelson, John M. ; Pálla, Gabriella ; Panagiotou, Apostolos D. ; Petridis, Athanasios ; Piper, Andreas ; Porter, R. Jefferson ; Poskanzer, Arthur M. ; Poziombka, Stefan ; Prindle, Duncan J. ; Pühlhofer, Falk ; Rauch, Wolfgang Hans ; Reid, Jeffrey G. ; Renfordt, Rainer Arno Ernst ; Retyk, Waldemar ; Ritter, Hans Georg ; Röhrich, Dieter ; Roland, Christof ; Roland, Gunther ; Rudolph, Heinrich ; Rybicki, Andrzej ; Sakrejda, Iwona ; Sandoval, Andres ; Sann, Hans ; Semenov, Alexei Yu. ; Schäfer, Erich ; Schmischke, Dirk ; Schmitz, Norbert ; Schönfelder, Stefan ; Seyboth, Peter ; Seyerlein, Jürgen ; Siklér, Ferenc ; Skrzypczak, Ewa ; Squier, Gordon Thomas Anderson ; Stock, Reinhard ; Ströbele, Herbert ; Szentpétery, Imre ; Sziklai, János ; Toy, Milton Y. ; Trainor, Thomas A. ; Trentalange, Stephen ; Ullrich, Thomas ; Vassiliou, Maria ; Vesztergombi, György ; Vranić, Danilo ; Wang, Feipeng ; Weerasundara, Dhammika D. ; Wenig, Siegfried ; Whitten, Charles A. ; Wienold, Thomas ; Wood, Lindsay ; Yates, Tim A. ; Zimányi, József ; Zhu, Xue-Zhou ; Zybert, Ryszard
Using the NA49 main TPC, the central production of hyperons has been measured in CERN SPS Pb - Pb collisions at 158 GeV c-1. The preliminary ratio, studied at 2.0 < y < 2.6 and 1 < pT < 3 GeV c-1, equals ~ (13 ± 4)% (systematic error only). It is compatible, within errors, with the previously obtained ratios for central S + S [1], S + W [2], and S + Au [3] collisions. The fit to the transverse momentum distribution resulted in an inverse slope parameter T of 297 MeV. At this level of statistics we do not see any noticeable enhancement of hyperon production with the increased volume (and, possibly, degree of equilibration) of the system from S + S to Pb + Pb. This result is unexpected and counterintuitive, and should be further investigated. If confirmed, it will have a significant impact on our understanding of mechanisms leading to the enhanced strangeness production in heavy-ion collisions.
Friese, Volker ; Afanasiev, Sergey V. ; Alber, Thomas ; Appelshäuser, Harald ; Bächler, Joachim ; Bailey, Stephen John ; Barnby, Lee Stuart ; Bartke, Jerzy ; Białkowska, Helena ; Blyth, Charles O. ; Bock, Rudolf ; Bormann, Christian ; Brady, Franklin Paul ; Brockmann, Robert ; Buncic, Nenad ; Bunčić, Predrag ; Caines, Helen Louise ; Cebra, Daniel A. ; Chan, P ; Cooper, Glenn E. ; Cramer, John G. ; Cramer, Pauline B. ; Csató, Péter ; Dietz, Oliver ; Dunn, Jason ; Eckardt, Volker ; Eckhardt, Frank ; Ferguson, M. I. ; Fischer, Hans Gerhard ; Flierl, Dominik Bernhard ; Fodor, Zoltán ; Foka, Panagiota ; Freund, Peter ; Friese, Volker ; Fuchs, M ; Gabler, Frank ; Gál, József ; Gaździcki, Marek ; Gładysz-Dziaduś, Ewa ; Grebieszkow, Jaroslaw ; Günther, Jörg ; Harris, John W. ; Hegyi, Sándor ; Henkel, Torsten ; Hill, L. A. ; Huang, Isaac ; Howe, Mark A. ; Hümmler, Holm Gero ; Igo, George J. ; Irmscher, Detlef ; Jacobs, Peter Martin ; Jones, Peter Graham ; Kadija, Krešo ; Kolesnikov, Vadim I. ; Kowalski, Marek ; Lasiuk, Brian ; Lévai, Péter ; Malakhov, Aleksandr I. ; Margetis, Spyridon ; Markert, Christina ; Melkumov, Georgy L. ; Mock, Andreas ; Molnár, József ; Nelson, John M. ; Odyniec, Grazyna Janina ; Pálla, Gabriella ; Panagiotou, Apostolos D. ; Petridis, Athanasios ; Piper, Andreas ; Porter, R. Jefferson ; Poskanzer, Arthur M. ; Poziombka, Stefan ; Prindle, Duncan J. ; Pühlhofer, Falk ; Rauch, Wolfgang Hans ; Reid, Jeffrey G. ; Renfordt, Rainer Arno Ernst ; Retyk, Waldemar ; Ritter, Hans Georg ; Röhrich, Dieter ; Roland, Christof ; Roland, Gunther ; Rudolph, Heinrich ; Rybicki, Andrzej ; Sakrejda, Iwona ; Sandoval, Andres ; Sann, Hans ; Semenov, Alexei Yu. ; Schäfer, Erich ; Schmischke, Dirk ; Schmitz, Norbert ; Schönfelder, Stefan ; Seyboth, Peter ; Seyerlein, Jürgen ; Siklér, Ferenc ; Skrzypczak, Ewa ; Squier, Gordon Thomas Anderson ; Stock, Reinhard ; Ströbele, Herbert ; Szentpétery, Imre ; Sziklai, János ; Toy, Milton Y. ; Trainor, Thomas A. ; Trentalange, Stephen ; Ullrich, Thomas ; Vassiliou, Maria ; Vesztergombi, György ; Vranić, Danilo ; Wang, Feipeng ; Weerasundara, Dhammika D. ; Wenig, Siegfried ; Whitten, Charles A. ; Wienold, Thomas ; Wood, Lindsay ; Yates, Tim A. ; Zimányi, József ; Zhu, Xue-Zhou ; Zybert, Ryszard
Preliminary data on phi production in central Pb + Pb collisions at 158 GeV per nucleon are presented, measured by the NA49 experiment in the hadronic decay channel phi - K+K-. At mid-rapidity, the kaons were separated from pions and protons by combining dE/dx and time-of-flight information; in the forward rapidity range only dE/dx identification was used to obtain the rapidity distribution and a rapidity-integrated mt-spectrum. The mid-rapidity yield obtained was dN/dy = 1.85 ± 0.3 per event; the total phi multiplicity was estimated to be 5.0 ± 0.7 per event. Comparison with published pp data shows a slight, but not very significant strangeness enhancement.
Ganz, Rudolf ; Appelshäuser, Harald ; Bächler, Joachim ; Bailey, Stephen John ; Barna, Daniel ; Barnby, Lee Stuart ; Bartke, Jerzy ; Barton, Robert Allan ; Białkowska, Helena ; Billmeier, Anja ; Blyth, Charles O. ; Bock, Rudolf ; Bormann, Christian ; Brady, Franklin Paul ; Brockmann, Robert ; Brun, René ; Bunčić, Predrag ; Caines, Helen Louise ; Cebra, Daniel A. ; Cooper, Glenn E. ; Cramer, John G. ; Cristinziani, Markus ; Csato, Péter ; Dunn, Jason ; Eckardt, Volker ; Eckhardt, Frank ; Ferguson, M. I. ; Fischer, Hans Gerhard ; Flierl, Dominik Bernhard ; Fodor, Zoltán ; Foka, Panagiota ; Freund, Peter ; Friese, Volker ; Fuchs, M. ; Gabler, Frank ; Gal, József ; Gaździcki, Marek ; Gładysz, Ewa ; Grebieszkow, Jaroslaw ; Gunther, J. ; Harris, John W. ; Hegyi, Sándor ; Henkel, Torsten ; Hill, L. A. ; Huang, Isaac ; Hümmler, Holm Gero ; Igo, George J. ; Irmscher, Detlef ; Jacobs, Peter Martin ; Jones, Peter Graham ; Kadija, Krešo ; Kolesnikov, Vadim I. ; Kowalski, Marek ; Lasiuk, Brian ; Lévai, Péter ; Malakhov, Aleksandr I. ; Margetis, Spyridon ; Markert, Christina ; Melkumov, Georgy L. ; Mock, Andreas ; Molnar, József ; Nelson, John M. ; Oldenburg, Markus D. ; Odyniec, Grazyna Janina ; Palla, Gabriella ; Panagiotou, Apostolos D. ; Petridis, Athanasios ; Piper, Andreas ; Porter, R. Jefferson ; Poskanzer, Arthur M. ; Poziombka, Stefan ; Prindle, Duncan J. ; Puhlhofer, Falk ; Rauch, Wolfgang Hans ; Reid, Jeffrey G. ; Renfordt, Rainer Arno Ernst ; Retyk, Waldemar ; Ritter, Hans Georg ; Röhrich, Dieter ; Roland, Christof ; Roland, Gunther ; Rudolph, Heinrich ; Rybicki, Andrzej ; Sandoval, Andres ; Sann, Hans ; Semenov, Alexei Yu. ; Schäfer, Erich ; Schmischke, Dirk ; Schmitz, Norbert ; Schönfelder, Stefan ; Seyboth, Peter ; Seyerlein, Jürgen ; Sikler, Ferenc ; Skrzypczak, Ewa ; Squier, Gordon Thomas Anderson ; Stock, Reinhard ; Ströbele, Herbert ; Szentpetery, Imre ; Sziklai, János ; Toy, Milton Y. ; Trainor, Thomas A. ; Trentalange, Stephen ; Ullrich, Thomas ; Vassiliou, Maria ; Veres, Gábor I. ; Vesztergombi, György ; Vranić, Danilo ; Wang, Feipeng ; Weerasundara, Dhammika D. ; Wenig, Siegfried ; Whitten, Charles A. ; Wienold, Thomas ; Wood, Lindsay ; Yates, Tim A. ; Zimanyi, József ; Zhu, X.Z. ; Zybert, Ryszard
The large acceptance TPCs of the NA49 spectrometer allow for a systematic multidimensional study of two-particle correlations in different part of phase space. Results from Bertsch-Pratt and Yano-Koonin-Podgoretskii parametrizations are presented differentially in transverse pair momentum and pair rapidity. These studies give an insight into the dynamical space-time evolution of relativistic Pb+Pb collisions, which is dominated by longitudinal expansion.
Lambda and Antilambda reconstruction in central Pb+Pb collisions using a time projection chamber
(1997)
Yates, Tim A. ; Afanasiev, Sergey V. ; Alber, Thomas ; Appelshäuser, Harald ; Bächler, Joachim ; Bailey, Stephen John ; Barnby, Lee Stuart ; Bartke, Jerzy ; Białkowska, Helena ; Blyth, Charles O. ; Bock, Rudolf ; Bormann, Christian ; Brady, Franklin Paul ; Brockmann, Robert ; Buncic, Nenad ; Bunčić, Predrag ; Caines, Helen Louise ; Cebra, Daniel A. ; Chan, P ; Cooper, Glenn E. ; Cramer, John G. ; Cramer, Pauline B. ; Csató, Péter ; Dietz, Oliver ; Dunn, Jason ; Eckardt, Volker ; Eckhardt, Frank ; Ferguson, M. I. ; Fischer, Hans Gerhard ; Flierl, Dominik Bernhard ; Fodor, Zoltán ; Foka, Panagiota ; Freund, Peter ; Friese, Volker ; Fuchs, M ; Gabler, Frank ; Gál, József ; Gaździcki, Marek ; Gładysz-Dziaduś, Ewa ; Grebieszkow, Jaroslaw ; Günther, Jörg ; Harris, John W. ; Hegyi, Sándor ; Henkel, Torsten ; Hill, L. A. ; Huang, Isaac ; Howe, Mark A. ; Hümmler, Holm Gero ; Igo, George J. ; Irmscher, Detlef ; Jacobs, Peter Martin ; Jones, Peter Graham ; Kadija, Krešo ; Kolesnikov, Vadim I. ; Kowalski, Marek ; Lasiuk, Brian ; Lévai, Péter ; Malakhov, Aleksandr I. ; Margetis, Spyridon ; Markert, Christina ; Melkumov, Georgy L. ; Mock, Andreas ; Molnár, József ; Nelson, John M. ; Odyniec, Grazyna Janina ; Pálla, Gabriella ; Panagiotou, Apostolos D. ; Petridis, Athanasios ; Piper, Andreas ; Porter, R. Jefferson ; Poskanzer, Arthur M. ; Poziombka, Stefan ; Prindle, Duncan J. ; Pühlhofer, Falk ; Rauch, Wolfgang Hans ; Reid, Jeffrey G. ; Renfordt, Rainer Arno Ernst ; Retyk, Waldemar ; Ritter, Hans Georg ; Röhrich, Dieter ; Roland, Christof ; Roland, Gunther ; Rudolph, Heinrich ; Rybicki, Andrzej ; Sakrejda, Iwona ; Sandoval, Andres ; Sann, Hans ; Semenov, Alexei Yu. ; Schäfer, Erich ; Schmischke, Dirk ; Schmitz, Norbert ; Schönfelder, Stefan ; Seyboth, Peter ; Seyerlein, Jürgen ; Siklér, Ferenc ; Skrzypczak, Ewa ; Squier, Gordon Thomas Anderson ; Stock, Reinhard ; Ströbele, Herbert ; Szentpétery, Imre ; Sziklai, János ; Toy, Milton Y. ; Trainor, Thomas A. ; Trentalange, Stephen ; Ullrich, Thomas ; Vassiliou, Maria ; Vesztergombi, György ; Vranić, Danilo ; Wang, Feipeng ; Weerasundara, Dhammika D. ; Wenig, Siegfried ; Whitten, Charles A. ; Wienold, Thomas ; Wood, Lindsay ; Zimányi, József ; Zhu, X Z ; Zybert, Ryszard
The large acceptance time projection chambers of the NA49 experiment are used to record the trajectory of charged particles from Pb + Pb collisions at 158 GeV per nucleon. Neutral strange hadrons have been reconstructed from their charged decay products. To obtain distributions of Λ, and Ks0 in discrete bins of rapidity, y, and transverse momentum, pT, calculations have been performed to determine the acceptance of the detector and the efficiency of the reconstruction software as a function of both variables. The lifetime distributions obtained give values of cτ = 7.8 ± 0.6 cm for Λ and cτ = 2.5 ± 0.3 cm for Ks0, consistent with data book values.
Levine, John E. ; Grupp, Stephan ; Pulsipher, Michael A. ; Dietz, Andrew C. ; Rives, Susana ; Myers, G. Douglas ; August, Keith J. ; Verneris, Michael R. ; Büchner, Jochen ; Laetsch, Theodore W. ; Bittencourt, Henrique ; Baruchel, Andre ; Boyer, Michael W. ; De Moerloose, Barbara ; Qayed, Muna ; Davies, Stella M. ; Phillips, Christine L. ; Driscoll, Timothy A. ; Bader, Peter ; Schlis, Krysta ; Wood, Patricia A ; Mody, Rajen ; Yi, Lan ; Leung, Mimi ; Eldjerou, Lamis K. ; June, Carl H. ; Maude, Shannon L
Background: Tisagenlecleucel, an anti-CD19 chimeric antigen receptor T cell therapy, has demonstrated efficacy in children and young adults with relapsed/refractory B cell acute lymphoblastic leukemia (B-ALL) in two multicenter phase 2 trials (ClinicalTrials.gov, NCT02435849 (ELIANA) and NCT02228096 (ENSIGN)), leading to commercialization of tisagenlecleucel for the treatment of patients up to age 25 years with B-ALL that is refractory or in second or greater relapse.
Methods: A pooled analysis of 137 patients from these trials (ELIANA: n=79; ENSIGN: n=58) was performed to provide a comprehensive safety profile for tisagenlecleucel.
Results: Grade 3/4 tisagenlecleucel-related adverse events (AEs) were reported in 77% of patients. Specific AEs of interest that occurred ≤8 weeks postinfusion included cytokine-release syndrome (CRS; 79% (grade 4: 22%)), infections (42%; grade 3/4: 19%), prolonged (not resolved by day 28) cytopenias (40%; grade 3/4: 34%), neurologic events (36%; grade 3: 10%; no grade 4 events), and tumor lysis syndrome (4%; all grade 3). Treatment for CRS included tocilizumab (40%) and corticosteroids (23%). The frequency of neurologic events increased with CRS severity (p<0.001). Median time to resolution of grade 3/4 cytopenias to grade ≤2 was 2.0 (95% CI 1.87 to 2.23) months for neutropenia, 2.4 (95% CI 1.97 to 3.68) months for lymphopenia, 2.0 (95% CI 1.87 to 2.27) months for leukopenia, 1.9 (95% CI 1.74 to 2.10) months for thrombocytopenia, and 1.0 (95% CI 0.95 to 1.87) month for anemia. All patients who achieved complete remission (CR)/CR with incomplete hematologic recovery experienced B cell aplasia; however, as nearly all responders also received immunoglobulin replacement, few grade 3/4 infections occurred >1 year postinfusion.
Conclusions: This pooled analysis provides a detailed safety profile for tisagenlecleucel during the course of clinical trials, and AE management guidance, with a longer follow-up duration compared with previous reports.
Alber, Thomas ; Appelshäuser, Harald ; Bächler, Joachim ; Bartke, Jerzy ; Białkowska, Helena ; Bieser, Fred ; Bloomer, Matthew A. ; Blyth, Charles O. ; Bock, Rudolf ; Bormann, Christian ; Brady, Franklin Paul ; Brockmann, Robert ; Bunčić, Predrag ; Caines, Helen Louise ; Cebra, Daniel A. ; Chan, Phaikying ; Cooper, Glenn E. ; Cramer, John G. ; Cramer, Pauline B. ; Csató, Péter ; Derado, Ivan ; Dunn, Jason ; Eckardt, Volker ; Eckhardt, Frank ; Euler, Sebastian ; Ferguson, M. I. ; Fischer, Hans Gerhard ; Fodor, Zoltán ; Foka, Panagiota ; Freund, Peter ; Fuchs, Matthias ; Gál, József ; Gaździcki, Marek ; Gładysz-Dziaduś, Ewa ; Grebieszkow, Jaroslaw ; Günther, Jörg ; Harris, John W. ; Heck, W. ; Hegyi, Sándor ; Hill, L. A. ; Huang, Isaac ; Howe, Mark A. ; Igo, George J. ; Irmscher, Detlef ; Jacobs, Peter Martin ; Jones, Peter Graham ; Kadija, Krešo ; Kecskemeti, J. ; Kowalski, Marek ; Kühmichel, Andreas ; Lasiuk, Brian ; Margetis, Spyridon ; Mitchell, J. W. ; Mock, Andreas ; Nelson, John M. ; Odyniec, Grazyna Janina ; Pálinkás, József ; Pálla, Gabriella ; Panagiotou, Apostolos D. ; Petridis, Athanasios ; Piper, Andreas ; Poskanzer, Arthur M. ; Prindle, Duncan J. ; Pühlhofer, Falk ; Rauch, Wolfgang Hans ; Renfordt, Rainer Arno Ernst ; Retyk, Waldemar ; Ritter, Hans Georg ; Röhrich, Dieter ; Rudolph, Heinrich ; Runge, Kay ; Sandoval, Andres ; Sann, Hans ; Schäfer, Erich ; Schmitz, Norbert ; Schönfelder, Stefan ; Seyboth, Peter ; Seyerlein, Jürgen ; Sikler, Ferenc ; Skrzypczak, Ewa ; Stock, Reinhard ; Ströbele, Herbert ; Szentpetery, Imre ; Sziklai, János ; Toy, Milton Y. ; Trainor, Thomas A. ; Trentalange, Stephen ; Vassiliou, Maria ; Vesztergombi, György ; Vranić, Danilo ; Wenig, Siegfried ; Whitten, Charles A. ; Wienold, Thomas ; Wood, Lindsay ; Zimanyi, József ; Zhu, X. -Z. ; Zybert, Ryszard