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The pseudorapidity density of charged particles with minimum transverse momentum (pT) thresholds of 0.15, 0.5, 1, and 2 GeV/c is measured in pp collisions at the centre of mass energies of s√= 5.02 and 13 TeV with the ALICE detector. The study is carried out for inelastic collisions with at least one primary charged particle having a pseudorapidity (η) within ±0.8 and pT larger than the corresponding threshold. In addition, measurements without pT-thresholds are performed for inelastic and non-single-diffractive events as well as for inelastic events with at least one charged particle having |η|<1 in pp collisions at s√= 5.02 TeV for the first time at the LHC. These measurements are compared to the PYTHIA 6, PYTHIA 8, and EPOS-LHC models. In general, the models describe the η dependence of particle production well. However, discrepancies are observed for the highest transverse momentum threshold (pT>2 GeV/c), highlighting the importance of such measurements for tuning event generators. The new measurements agree within uncertainties with results from the ATLAS and CMS experiments obtained at s√=13 TeV.
The production of K∗(892)0 and ϕ(1020) resonances has been measured in p-Pb collisions at sNN−−−√ = 8.16 TeV using the ALICE detector. Resonances are reconstructed via their hadronic decay channels in the rapidity interval −0.5 < y < 0 and the transverse momentum spectra are measured for various multiplicity classes up to pT = 20 GeV/c for K∗(892)0 and pT = 16 GeV/c for ϕ(1020). The pT -integrated yields and mean transverse momenta are reported and compared with previous results in pp, p-Pb and Pb-Pb collisions. The xT scaling for K∗(892)0 and ϕ(1020) resonance production is newly tested in p-Pb collisions and found to hold in the high-pT region at LHC energies. The nuclear modification factors (RpPb) as a function of pT for K∗0 and ϕ at sNN−−−−√ = 8.16 TeV are presented along with the new RpPb measurements of K∗0, ϕ , Ξ, and Ω at sNN−−−√ = 5.02 TeV. At intermediate pT (2-8 GeV/c), RpPb of Ξ, Ω show a Cronin-like enhancement, while K∗0 and ϕ show no or little nuclear modification. At high pT (> 8 GeV/c), the RpPb values of all hadrons are consistent with unity within uncertainties. The RpPb of K∗(892)0 and ϕ(1020) at sNN−−−√ = 8.16 and 5.02 TeV show no significant energy dependence.
The production of K∗(892)0 and ϕ(1020) resonances has been measured in p-Pb collisions at sNN−−−√ = 8.16 TeV using the ALICE detector. Resonances are reconstructed via their hadronic decay channels in the rapidity interval −0.5 < y < 0 and the transverse momentum spectra are measured for various multiplicity classes up to pT = 20 GeV/c for K∗(892)0 and pT = 16 GeV/c for ϕ(1020). The pT -integrated yields and mean transverse momenta are reported and compared with previous results in pp, p-Pb and Pb-Pb collisions. The xT scaling for K∗(892)0 and ϕ(1020) resonance production is newly tested in p-Pb collisions and found to hold in the high-pT region at Large Hadron Collider energies. The nuclear modification factors (RpPb) as a function of pT for K∗0 and ϕ at sNN−−−−√ = 8.16 TeV are presented along with the new RpPb measurements of K∗0, ϕ , Ξ, and Ω at sNN−−−√ = 5.02 TeV. At intermediate pT (2-8 GeV/c), RpPb of Ξ, Ω show a Cronin-like enhancement, while K∗0 and ϕ show no or little nuclear modification. At high pT (> 8 GeV/c), the RpPb values of all hadrons are consistent with unity within uncertainties. The RpPb of K∗(892)0 and ϕ(1020) at sNN−−−√ = 8.16 and 5.02 TeV show no significant energy dependence.
The production of K∗(892)0 and ϕ(1020) resonances has been measured in p-Pb collisions at sNN−−−√ = 8.16 TeV using the ALICE detector. Resonances are reconstructed via their hadronic decay channels in the rapidity interval −0.5 < y < 0 and the transverse momentum spectra are measured for various multiplicity classes up to pT = 20 GeV/c for K∗(892)0 and pT = 16 GeV/c for ϕ(1020). The pT -integrated yields and mean transverse momenta are reported and compared with previous results in pp, p-Pb and Pb-Pb collisions. The xT scaling for K∗(892)0 and ϕ(1020) resonance production is newly tested in p-Pb collisions and found to hold in the high-pT region at Large Hadron Collider energies. The nuclear modification factors (RpPb) as a function of pT for K∗0 and ϕ at sNN−−−−√ = 8.16 TeV are presented along with the new RpPb measurements of K∗0, ϕ , Ξ, and Ω at sNN−−−√ = 5.02 TeV. At intermediate pT (2-8 GeV/c), RpPb of Ξ, Ω show a Cronin-like enhancement, while K∗0 and ϕ show no or little nuclear modification. At high pT (> 8 GeV/c), the RpPb values of all hadrons are consistent with unity within uncertainties. The RpPb of K∗(892)0 and ϕ(1020) at sNN−−−√ = 8.16 and 5.02 TeV show no significant energy dependence.
Inclusive transverse momentum spectra of primary charged particles in Pb–Pb collisions at √sNN=2.76 TeV have been measured by the ALICE Collaboration at the LHC. The data are presented for central and peripheral collisions, corresponding to 0–5% and 70–80% of the hadronic Pb–Pb cross section. The measured charged particle spectra in |η|<0.8 and 0.3<pT<20 GeV/c are compared to the expectation in pp collisions at the same sNN, scaled by the number of underlying nucleon–nucleon collisions. The comparison is expressed in terms of the nuclear modification factor RAA. The result indicates only weak medium effects (RAA≈0.7) in peripheral collisions. In central collisions, RAA reaches a minimum of about 0.14 at pT=6–7 GeV/c and increases significantly at larger pT. The measured suppression of high-pT particles is stronger than that observed at lower collision energies, indicating that a very dense medium is formed in central Pb–Pb collisions at the LHC.
The ALICE Collaboration has measured inclusive J/ψ production in pp collisions at a center-of-mass energy √s=2.76 TeV at the LHC. The results presented in this Letter refer to the rapidity ranges |y|<0.9 and 2.5<y<4 and have been obtained by measuring the electron and muon pair decay channels, respectively. The integrated luminosities for the two channels are Linte=1.1 nb−1 and Lintμ=19.9 nb−1, and the corresponding signal statistics are NJ/ψe+e−=59±14 and NJ/ψμ+μ−=1364±53. We present dσJ/ψ/dy for the two rapidity regions under study and, for the forward-y range, d2σJ/ψ/dydpt in the transverse momentum domain 0<pt<8 GeV/c. The results are compared with previously published results at s=7 TeV and with theoretical calculations.
The ALICE Collaboration reports the measurement of the relative J/ψ yield as a function of charged particle pseudorapidity density dNch/dη in pp collisions at √s=7 TeV at the LHC. J/ψ particles are detected for pt>0, in the rapidity interval |y|<0.9 via decay into e+e−, and in the interval 2.5<y<4.0 via decay into μ+μ− pairs. An approximately linear increase of the J/ψ yields normalized to their event average (dNJ/ψ/dy)/〈dNJ/ψ/dy〉 with (dNch/dη)/〈dNch/dη〉 is observed in both rapidity ranges, where dNch/dη is measured within |η|<1 and pt>0. In the highest multiplicity interval with 〈dNch/dη(bin)〉=24.1, corresponding to four times the minimum bias multiplicity density, an enhancement relative to the minimum bias J/ψ yield by a factor of about 5 at 2.5<y<4 (8 at |y|<0.9) is observed.
The inclusive charged particle transverse momentum distribution is measured in proton–proton collisions at s=900 GeV at the LHC using the ALICE detector. The measurement is performed in the central pseudorapidity region (|η|<0.8) over the transverse momentum range 0.15<pT<10 GeV/c. The correlation between transverse momentum and particle multiplicity is also studied. Results are presented for inelastic (INEL) and non-single-diffractive (NSD) events. The average transverse momentum for |η|<0.8 is 〈pT〉INEL=0.483±0.001 (stat.)±0.007 (syst.) GeV/c and 〈pT〉NSD=0.489±0.001 (stat.)±0.007 (syst.) GeV/c, respectively. The data exhibit a slightly larger 〈pT〉 than measurements in wider pseudorapidity intervals. The results are compared to simulations with the Monte Carlo event generators PYTHIA and PHOJET.
Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α‐mediated stress signaling
(2016)
Phosphorylation of translation initiation factor 2α (eIF2α) attenuates global protein synthesis but enhances translation of activating transcription factor 4 (ATF4) and is a crucial evolutionarily conserved adaptive pathway during cellular stresses. The serine–threonine protein phosphatase 1 (PP1) deactivates this pathway whereas prolonging eIF2α phosphorylation enhances cell survival. Here, we show that the reactive oxygen species‐generating NADPH oxidase‐4 (Nox4) is induced downstream of ATF4, binds to a PP1‐targeting subunit GADD34 at the endoplasmic reticulum, and inhibits PP1 activity to increase eIF2α phosphorylation and ATF4 levels. Other PP1 targets distant from the endoplasmic reticulum are unaffected, indicating a spatially confined inhibition of the phosphatase. PP1 inhibition involves metal center oxidation rather than the thiol oxidation that underlies redox inhibition of protein tyrosine phosphatases. We show that this Nox4‐regulated pathway robustly enhances cell survival and has a physiologic role in heart ischemia–reperfusion and acute kidney injury. This work uncovers a novel redox signaling pathway, involving Nox4–GADD34 interaction and a targeted oxidative inactivation of the PP1 metal center, that sustains eIF2α phosphorylation to protect tissues under stress.
An experiment addressing electron capture (EC) decay of hydrogen-like 142Pm60+ions has been conducted at the experimental storage ring (ESR) at GSI. The decay appears to be purely exponential and no modulations were observed. Decay times for about 9000 individual EC decays have been measured by applying the single-ion decay spectroscopy method. Both visually and automatically analysed data can be described by a single exponential decay with decay constants of 0.0126(7)s−1 for automatic analysis and 0.0141(7)s−1 for manual analysis. If a modulation superimposed on the exponential decay curve is assumed, the best fit gives a modulation amplitude of merely 0.019(15), which is compatible with zero and by 4.9 standard deviations smaller than in the original observation which had an amplitude of 0.23(4).