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- transforming growth factor-β (2)
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Die Hessische Schülerakademie 2014 stand ganz im Zeichen ihres 10jährigen Bestehens. Seit Gründung der Oberstufenakademie im Jahre 2004 durch Cynthia Hog-Angeloni und Wolfgang Metzler hat sich die "HSAKA" selbstverständlich verändert; das ist bei einem so ambitionierten Projekt auch gar nicht anders denkbar. Die Hessische Schülerakademie hat sich behauptet, indem sie immer wieder neue Impulse aufgenommen und sich beständig um Verbesserung bemüht hat – und sie ist gewachsen.
Reading is not only "cold" information processing, but involves affective and aesthetic processes that go far beyond what current models of word recognition, sentence processing, or text comprehension can explain. To investigate such "hot" reading processes, standardized instruments that quantify both psycholinguistic and emotional variables at the sublexical, lexical, inter-, and supralexical levels (e.g., phonological iconicity, word valence, arousal-span, or passage suspense) are necessary. One such instrument, the Berlin Affective Word List (BAWL) has been used in over 50 published studies demonstrating effects of lexical emotional variables on all relevant processing levels (experiential, behavioral, neuronal). In this paper, we first present new data from several BAWL studies. Together, these studies examine various views on affective effects in reading arising from dimensional (e.g., valence) and discrete emotion features (e.g., happiness), or embodied cognition features like smelling. Second, we extend our investigation of the complex issue of affective word processing to words characterized by a mixture of affects. These words entail positive and negative valence, and/or features making them beautiful or ugly. Finally, we discuss tentative neurocognitive models of affective word processing in the light of the present results, raising new issues for future studies.
4 June 2013 marked the formal launch of the third generation of the Equator Principles (EP III) and the tenth anniversary of the EPs – enough reasons for evaluating the EPs initiative from an economic ethics and business ethics perspective. This chapter deals with the following questions: What has been achieved so far by the EPs? Which reform steps need to be adopted to further strengthen the EPs framework? Can the EPs be regarded as a role model in the field of sustainable finance and CSR? The first part explains the term EPs and introduces the keywords related to the EPs framework. The second part summarises the main characteristics of the newly-released third generation of the EPs. The third part critically evaluates EP III from an economic ethical and business ethics perspective. The chapter concludes with a summary of the main findings.
June 4th, 2013 marks the formal launch of the third generation of the Equator Principles (EP III) and the tenth anniversary of the EPs – enough reasons for evaluating the EPs initiative from an economic ethics and business ethics perspectives. In particular, this essay deals with the following questions: What are the EPs and where are they going? What has been achieved so far by the EPs? What are the strengths and weaknesses of the EPs? Which necessary reform steps need to be adopted in order to further strengthen the EPs framework? Can the EPs be regarded as a role-model in the field of sustainable finance and CSR? The paper is structured as follows: The first chapter defines the term EPs and introduces the keywords related to the EPs framework. The second chapter gives a brief overview of the history of the EPs. The third chapter discusses the Equator Principles Association, the governing, administering, and managing institution behind the EPs. The fourth chapter summarizes the main features and characteristics of the newly released third generation of the EPs. The fifth chapter critically evaluates the EP III from an economic ethics and business ethics perspectives. The paper concludes with a summary of the main findings.
1.000 Handschriften online : Universitätsbibliothek digitalisiert wertvolle Handschriftensammlung
(2013)
Wie sieht die Zukunft der Wertschöpfung aus? Lässt sich eine "Demokratisierung" der Wertschöpfung beobachten? Befinden wir uns inmitten eines Paradigmenwechsels von der Industriellen Produktion hin zur Bottom-up-Ökonomie? Und wenn ja, was bedeutet das für die Gesellschaft?
Um diese Fragen aus verschiedenen wissenschaftlichen Perspektiven zu betrachten und gemeinschaftlich die damit zusammenhängenden gesellschaftlichen Chancen und Herausforderungen zu diskutieren, wurde das neue Konferenzformat "Interdisziplinäre Konferenz zur Zukunft der Wertschöpfung" geschaffen. Neben dem themenübergreifenden fachlichen Austausch ist auch die Vernetzung zwischen Wissenschaftlern/innen und Experten aus der Praxis ein Ziel dieser Reihe.
Der vorliegende Konferenzband beinhaltet die Beiträge der teilnehmenden Wissenschaftlicher/innen aus den Technik-, Wirtschafts-, Sozial- und Rechtswissenschaften und gibt einen Überblick über die aktuellen Forschungsschwerpunkte in den jeweiligen Fachgebieten. Die akademische Qualitätssicherung erfolgte mit Hilfe eines Peer-Review-Verfahrens. ...
Erstmalig wurde im Jahr 2011 auf BURG FÜRSTENECK eine Hessische Schülerakademie für die Mittelstufe (7-9) durchgeführt. 60 Schülerinnen und Schüler nahmen während der Herbstferien für die Dauer von zehn Tagen an Haupt- und Wahlkursen aus Themenbereichen der Chemie, Biologie, Mathematik, Wirtschaftsethik sowie der Kulturwissenschaften und ästhetischen Bildung teil.
1. Hessische Schülerakademie : schulpraktische Veranstaltung für Lehramtsstudierende : Dokumentation
(2004)
5-Lipoxygenase (5-LO) catalysis is positively regulated by Ca2+ ions and phospholipids that both act via the N-terminal C2-like domain of 5-LO. Previously, we have shown that 1-oleoyl-2-acetylglycerol (OAG) functions as an agonist for human polymorphonuclear leukocytes (PMNL) in stimulating 5-LO product formation. Here we have demonstrated that OAG directly stimulates 5-LO catalysis in vitro. In the absence of Ca2+ (chelated using EDTA), OAG strongly and concentration-dependently stimulated crude 5-LO in 100,000 x g supernatants as well as purified 5-LO enzyme from PMNL. Also, the monoglyceride 1-O-oleyl-rac-glycerol and 1,2-dioctanoyl-sn-glycerol were effective, whereas various phospholipids did not stimulate 5-LO. However, in the presence of Ca2+, OAG caused no stimulation of 5-LO. Also, phospholipids or cellular membranes abolished the effects of OAG. As found previously for Ca2+, OAG renders 5-LO activity resistant against inhibition by glutathione peroxidase activity, and this effect of OAG is reversed by phospholipids. Intriguingly, a 5-LO mutant lacking tryptophan residues (Trp-13, -75, and -102) important for the binding of the 5-LO C2-like domain to phospholipids was not stimulated by OAG. We conclude that OAG directly stimulates 5-LO by acting at a phospholipid binding site located within the C2-like domain.
The title molecule, C17H25N3O3, is built up from fused six- and five-membered rings linked to a –C10H21 chain. The fused-ring system is essentially planar, the largest deviation from the mean plane being 0.009 (2) Å. The chain is roughly perpendicular to this plane, making a dihedral angle of 79.5 (2)°. In the crystal, N—H[cdots, three dots, centered]O hydrogen bonds build infinite chains along [010]. There are channels in the structure containing disordered hexane. The contribution of this solvent to the scattering power was suppressed using the SQUEEZE option in PLATON [Spek (2009 [triangle]). Acta Cryst. D65, 148–155].
The fused five- and six-membered rings in the title compound, C14H12N2O, are essentially planar, the largest deviation from the mean plane being 0.023 (2) Å. The dihedral angle between the benzimidazole mean plane and the phenyl ring is 68.50 (6)°. In the crystal, each molecule is linked to its symmetry equivalent created by a crystallographic inversion center by pairs of N—H[cdots, three dots, centered]O hydrogen bonds, forming inversion dimers.
1-(Bromomercurio)ferrocene
(2013)
The asymmetric unit of the title compound, [Fe(C5H5)(C5H4BrHg)], contains two independent molecules, A and B, in which the Hg-C bond lengths are 2.045 (6) and 2.046 (6) Å, the Hg-Br bond lengths are 2.4511 (9) and 2.4562 (7) Å, and the C-Hg-Br angles are 176.42 (17) and 177.32 (17)°. The two cyclopentadienyl rings of mol-ecule A are eclipsed, while those of mol-ecule B are almost staggered. The HgBr groups are connected by intermolecular Hg⋯Br contacts of 3.3142 (9)-3.4895 (11) Å, forming layers parallel to (001). These layers contain both four-membered (HgBr)2 and eight-membered (HgBr)4 rings. Ferrocene-ferrocene C-H⋯π contacts connect the molecular layers along the c-axis direction.
In the title compound, C11H11N3O2, the dihedral angle between the central ethanone fragment and the 4-methoxyphenyl group is 2.9 (2)°, while that between the ethanone fragment and the triazole ring is 83.4 (2)°. The dihedral angle between the planes of the triazole and benzene rings is 81.7 (1)°. The 4-methoxyphenyl group is cis with respect to the ethanone fragment O atom across the exocyclic C—C bond. In the crystal, molecules are linked by C—H ... N interactions into C(9) chains along [001].
The title compound, C8H11FN5 +·Cl-, crystallized with a monoprotonated 1-(4-fluorophenyl)biguanidinium cation and a chloride anion in the asymmetric unit. The biguanidium group is not planar [dihedral angle between the two CN3 groups = 52.0 (1)°] and is rotated with respect to the phenyl group [tau = 54.3 (3)°]. In the crystal, N—H ... N hydrogen-bonded centrosymmetric dimers are connected into ribbons, which are further stabilized by N—H ... Cl interactions, forming a three-dimensional hydrogen-bonded network.
The dihydropyrimidine ring of the title compound, C13H15ClN2S, adopts an envelope conformation with five almost coplanar atoms (r.m.s. deviation = 0.054 Å) and the C atom bearing the two methyl substituents deviating from this plane by 0.441 (2) Å. The best plane through the five almost coplanar atoms forms a dihedral angle of 89.56 (5)° with the benzene ring. The crystal packing is characterized by centrosymmetric dimers connected by pairs of N—H ... S hydrogen bonds.
In the molecular structure of the title compound, C21H18N2O, the fused-ring system is essentially planar, the largest deviation from the mean plane being 0.0121 (9) Å. The O atom and adjacent C atom are located in Wyckoff position 4e on a twofold axis (0, y, 1/4). The two benzyl groups are almost perpendicular to the benzimidazole plane, but point in opposite directions. The dihedral angle between the benzimidazole mean plane and the phenyl ring is 81.95 (5)°, whereas that between the two benzyl groups is 60.96 (7)°.
In the mol-ecule of the title compound, C(12)H(12)BrN(3)O, the fused-ring system is essentially planar, the largest deviation from the mean plane being 0.0148 (3) Å. The two allyl groups are nearly perpendicular to the imidazo[4,5-b]pyridine plane [C-C-N-C torsion angles of 81.6 (4) and -77.2 (4)°] and point in the same direction. The planes through the atoms forming each allyl group are nearly perpendicular to the imidazo[4,5-b]pyridin-2-one system, as indicated by the dihedral angles between them of 80.8 (5) and 73.6 (5)°.
The asymmetric unit of the title compound, C21H28N4O, consists of two unique molecules linked by an O—H⋯N hydrogen bond. The conformation of both C=N bonds is E and the azomethine functional groups lie close to the plane of their associated benzene rings in each of the independent molecules. The dihedral angles between the two benzene rings are 83.14 (4) and 75.45 (4)°. The plane of the one of the N(CH3)2 units is twisted away from the benzene ring by 18.8 (2)°, indicating loss of conjugation between the lone electron pair and the benzene ring. In the crystal structure, O—H⋯N hydrogen bonds together with C—H⋯O hydrogen bonds link neighbouring supramolecular dimers into a three-dimensional network.
The asymmetric unit of the title compound, C28H42N2O5·H2O, consists of one half of the organic molecule and one half-molecule of water, both of which are located on a mirror plane which passes through the central C atoms and the hydroxyl group of the heterocyclic system. The hydroxyl group at the central ring is disordered over two equally occupied positions. The six-membered ring adopts a chair conformation, and the 2-hydroxybenzyl substituents occupy the sterically preferred equatorial positions. The aromatic rings make dihedral angles of 75.57 (9)° with the mean plane of the heterocyclic ring. The dihedral angle between the two aromatic rings is 19.18 (10)°. The molecular structure features two intramolecular phenolic O-H...N hydrogen bonds with graph-set motif S(6). In the crystal, molecules are connected via O-H...O hydrogen bonds into zigzag chains running along the a-axis direction.
In the title compound, C27H37N2 +·Cl−·2CH2Cl2, the cation and the anion are each located on a crystallographic mirror plane. Both of the dichloromethane solvent molecules show a disorder across a mirror plane over two equally occupied positions. Additionally, one isopropyl group is also disordered. In the crystal, the cations are connected to the chloride ions via C—H[cdots, three dots, centered]Cl hydrogen bonds.
In the title compound, C27H37N2 +·Br−·2CH2Cl2, both the cation and the anion are located on a crystallographic mirror plane. Both of the dichloromethane solvent molecules show a disorder across a mirror plane over two equally occupied positions. In the crystal, the cations are connnected to the bromide ions via C—H[cdots, three dots, centered]Br hydrogen bonds.
The title molecule, C34H28I4·4C6H6, has crystallographic 4 symmetry and crystallizes with four symmetry-related benzene solvent molecules. The phenyl group is eclipsed with one of the adamantane C—C bonds. The tetraphenyladamantane units and the benzene solvent molecules are connected by weak intermolecular phenyl–benzene C—H⋯π and benzene–benzene C—H⋯π interactions. In the crystal, molecules are linked along the c-axis direction via the iodophenyl groups by a combination of weak intermolecular I⋯I [3.944 (1) Å] and I⋯π(phenyl) [3.608 (6) and 3.692 (5) Å] interactions.
The central structural element of the title compound, C24H29NO2, is a carbazole unit substituted with two acetyl residues and an octyl chain. The acetyl residues are nearly coplanar [dihedral angles = 5.37 (14) and 1.0 (3)°] with the carbazole unit which is essentially planar (r.m.s. deviation for all non-H atoms = 0.025 Å). The octyl chain adopts an all-trans conformation. The crystal packing is stabilized by C—H ... O hydrogen bonds.
The title compound, C22H28N2O6, crystallizes with four half-molecules in the asymmetric unit: each molecule is located about a crystallographic inversion centre. The central methylene groups of two molecules are disordered over two sets of equally occupied sites. The crystal packing is characterized by sheets of molecules parallel to (114).
The title compound, C30H16N4O4, reveals \overline1 crystallographic and molecular symmetry and accordingly the asymmetric unit comprises one half-molecule. The dihedral angle between the planes of the two geminal benzoxazole rings is 74.39 (5)°. The packing features weak C-H...N and [pi]-[pi] interactions [centroid-centroid distance = 3.652 (1) Å].
Diese Arbeit untersucht die Perzeption der Vokale /a/, /ɐ/ und /ɐ̃/ durch deutsche erwachsene Portugiesischlerner. Ziel war herauszufinden, ob deutsche L1-Sprecher in der Lage sind, die genannten Laute zu unterscheiden, unter anderem in Abhängigkeit von ihrem Fremdsprachenniveau im EP.
Die Teilnehmer der Studie waren 27 deutsche Muttersprachler, die EP im Erwachsenenalter und zumeist an der Universität erlernen oder erlernt haben. Die Kontrollgruppe bildeten 33 portugiesische Muttersprachler. Beide Gruppen nahmen an einem Online-Perzeptionstest teil, dessen Aufbau sich an der Studie von Darcy und Krüger (2012) orientiert. Während des Tests mussten die Probanden aus einer Lautsequenz von drei einsilbigen Kunstwörtern mit der Silbenstruktur CVC dasjenige Kunstwort identifizieren, das einen anderen Vokal beinhaltete als die anderen zwei. Neben dem Perzeptionstest nahmen alle Teilnehmer an einem Einstufungstest für das EP teil, der aus einem C-Test und einem Vokabeltest bestand.
i può probabilmente acconsentire a quel giudizio di Francesco Guicciardini che le capacità, il talento e la saggezza del principe si specchiano anche nella scelta dei suoi ambasciatori. È perciò un aspetto molto affascinante di questo libro il mettere a fuoco gli attori ed esecutori dei potentati ed esaminare la loro interazione e comunicazione con il reggente. Sembra particolarmente interessante studiare gli incaricati di missioni diplomatiche di Massimiliano I visto che queste diedero il via all’ascesa della sua casata – non solo nei regni iberici ma anche in Boemia ed in Ungheria – non per mezzo della guerra, ma mediante la diplomazia, attraverso le trattative e le negoziazioni matrimoniali. Gregor Metzig che dichiara di volersi distaccare, con la sua tesi di dottorato, dalla «storiografia diplomatica convenzionale» e dalla tendenza classica a considerare la «politica europea» di Massimiliano come una «semplice catena di avvenimenti alternanti tra guerre, tregue e riprese delle ostilità tra le case rivaleggianti» (2), si mette sulle tracce di queste persone abili e valenti, gli ambasciatori, che operarono con, per e all’ombra di Massimiliano I e che sono spesso cadute vittime dell’oblio. ...
(Wie) Komme ich da rein? – der digitale Lageplan zur Barrierefreiheit der Universität Göttingen
(2023)
Lagepläne enthalten in der Regel raumbezogene Informationen, die für viele, aber nicht für alle Menschen nutzbar sind. Der barrierefreie Lageplan stellt zusätzliche Informationen zur Verfügung. Denn die chancengleiche Teilhabe an Studium und Lehre setzt für viele die barrierefreie Zugänglichkeit und Nutzbarkeit der Universität und ihrer Räumlichkeiten voraus. Angestoßen durch den jährlich stattfindenden Ideenwettbewerb für Studierende wurde 2012 unter dem Thema „Diversität? – Vielfalt fördern!“ der Vorschlag „Broschüre zu Barrieren und Barrierefreiheit auf dem Campus“ prämiert. In Kooperation der Beauftragten für Studierende mit Behinderungen und chronischen Erkrankungen mit dem Geographischen Institut konnte das Studienprojekt „Gebäude- und Raumauskunftssystem für die Georg-August-Universität Göttingen“ (GRAS_Geo) um Daten zur Barrierefreiheit der universitären Gebäude und Räume erweitert werden. Seit 2015 werden diese in einem interaktiven Online-Lageplan dargestellt und stetig um weitere Points of Interest ergänzt. Mittlerweile finden sich auf der digitalen Karte auch Standorte von Bushaltestellen und eine Vielzahl an Angeboten aus den Bereichen: Gleichstellung, Diversität und Familie sowie Studium, Campussicherheit, Kultur, Freizeit und Gastronomie. Für die Realisierung des Projekts wurden weitreichende Kartierungsmaßnahmen durchgeführt, um Datenlücken hinsichtlich der Kriterien zur Barrierefreiheit zu schließen und mit bereits verfügbaren Informationen aus den Gebäudedaten der Universitätsverwaltung zusammenzuführen. So bietet die Anwendung neben den reinen Daten zur Barrierefreiheit der Gebäude in Schriftform auch Fotos zur Orientierung und integriert Veranstaltungen aus dem Vorlesungsverzeichnis und Abfahrtszeiten von Bussen direkt in den Lageplan. Studierenden, Universitätsangehörigen und Gästen wird so die Orientierung auf dem Campus erleichtert.
Background: The rate of caesarean sections increased in the last decades to about 30% of births in western populations. Many caesarean sections are electively planned without an urgent medical reason for mother or child. Especially in women with a foregoing caesarean section, the procedure is planned early. An early caesarean section though may harm the newborn. Our aim is to evaluate the gestational time point after the 37th gestational week (after prematurity = term) of performing an elective caesarean section with the lowest morbidity for mother and child.
Methods: This is an update of a systematic review previously carried out on behalf of the German Federal Ministry of Health. We will perform a systematic literature search in MEDLINE, EMBASE, CENTRAL and CINAHL. Our primary outcome is the rate of admissions to the neonatal intensive care unit in early versus late term neonates. We will include (quasi) randomized controlled trials and cohort studies. The studies should include pregnant women who have an elective caesarean section at term. We will screen titles and abstracts and the identified full texts of studies for eligibility. Risk of bias will be assessed with the Cochrane Risk of Bias Tool for Randomized Trials or with the Risk of Bias Tool for Non-Randomized Studies of Interventions (ROBINS-I). These tasks will be performed independently by two reviewers. Data will be extracted in beforehand piloted extraction tables. A dose-response meta-analysis will be performed.
Discussion: Our aim is to reach a higher validity in the assessment of the time point of elective caesarean sections by performing a meta-analysis to support recommendations for clinical practice. We assume to identify less randomized controlled trials but a large number of cohort studies analyzing the given question. We will discuss similarities and differences in included studies as well as methodological strengths and weaknesses.
Systematic review registration: PROSPERO CRD42017078231
(Un)glaubwürdig grün? : Wie Anleger im boomenden Markt für Grüne Anleihen nach Orientierung suchen
(2020)
Der Klimaschutz ist in der Finanzwelt angekommen. Diesen Eindruck erweckt zumindest das wachsende Angebot an »grünen« Anleihen. Diese Wertpapiere beschaffen Kapital für explizit klimafreundliche Industrien und Projekte. Doch können Anleger sicher sein, dass sie ihr Geld in einen klimafreundlichen CO2-Fußabdruck investieren und nicht doch beim »Greenwashing« eines rasant ressourcenabbauenden Unternehmens Beihilfe leisten? Die Wirtschaftswissenschaftlerin Julia Kapraun hat sich mit der Glaubwürdigkeit Grüner Anleihen befasst.
The term structure of interest rates is crucial for the transmission of monetary policy to financial markets and the macroeconomy. Disentangling the impact of monetary policy on the components of interest rates, expected short rates and term premia, is essential to understanding this channel. To accomplish this, we provide a quantitative structural model with endogenous, time-varying term premia that are consistent with empirical findings. News about future policy, in contrast to unexpected policy shocks, has quantitatively significant effects on term premia along the entire term structure. This provides a plausible explanation for partly contradictory estimates in the empirical literature.
The term structure of interest rates is crucial for the transmission of monetary policy to financial markets and the macroeconomy. Disentangling the impact of monetary policy on the components of interest rates, expected short rates, and term premia is essential to understanding this channel. To accomplish this, we provide a quantitative structural model with endogenous, time-varying term premia that are consistent with empirical findings. News about future policy, in contrast to unexpected policy shocks, has quantitatively significant effects on term premia along the entire term structure. This provides a plausible explanation for partly contradictory estimates in the empirical literature.
Motivated by the U.S. events of the 2000s, we address whether a too low for too long interest rate policy may generate a boom-bust cycle. We simulate anticipated and unanticipated monetary policies in state-of-the-art DSGE models and in a model with bond financing via a shadow banking system, in which the bond spread is calibrated for normal and optimistic times. Our results suggest that the U.S. boom-bust was caused by the combination of (i) too low for too long interest rates, (ii) excessive optimism and (iii) a failure of agents to anticipate the extent of the abnormally favorable conditions.
Bis(N,N-diethyl-N′-benzoylselenoureato)lead(II) has been prepared and characterized by single-crystal structure analysis. Pb(C12H15N2OSe)2 crystallizes in the non-centrosymmetric orthorhombic space group Iba2. The cell parameters are a = 13.206(3), b = 20.542(4), c = 10.089(2) A and Z = 4. R = 0.025. The direction of the polar axis was determined unambig uously. Pb(II) is bidentally coordinated to two N,N-diethyl-N′-benzoylselenourea molecules. The coordination polyhedron is a distorted pseudo-trigonal bi-pyramid with one equatorial position occupied by an electron lone-pair. The Pb-Se and Pb-O bond lengths are 2.876(1) and 2.444(4) Å, respectively. In the crystal lattice, each Pb atom also shows interactions with two Se atoms of a neighboring molecule. The Pb-Se distance of that interaction is 3.643 Å.
This study explores how ‘gatherings’ turn into ‘encounters’ in a virtual world (VW) context. Most communication technologies enable only focused encounters between distributed participants, but in VWs both gatherings and encounters can occur. We present close sequential analysis of moments when after a silent gathering, interaction among participants in a VW is gradually resumed, and also investigate the social actions in the verbal (re-)opening turns. Our findings show that like in face-to-face situations, also in VWs participants often use different types of embodied resources to achieve the transition, rather than rely on verbal means only. However, the transition process in VWs has distinctive characteristics compared to the one in face-to-face situations. We discuss how participants in a VW use virtually embodied pre-beginnings to display what we call encounter-readiness, instead of displaying lack of presence by avatar stillness. The data comprise 40 episodes of video-recorded team interactions in a VW.
Die vorliegende Arbeit diskutiert Auffassungen über Authentizität und Nationale Identität in Julian Barnes’ England, England und Brian Moore’s The Great Victorian Collection. Julian Barnes und Brian Moore bearbeiten postmoderne Themen in ihrer Auseinandersetzung mit Realität und Authentizität. Brian Moore diskutiert die Möglichkeit der Ununterscheidbarkeit zwischen Original und Replika, Julian Barnes verdeutlicht die Konsequenzen eines Nationalgefühls, das sich auf die Vorstellung einer verklärten Vergangenheit stützt anstatt sich den Problemen der Gegenwart zu stellen.
Die postmoderne Diskussion hinterfragt Theorien der Moderne. In der Moderne entwickelten sich Nationalstaaten zur grundlegenden politischen Struktur, die eine für den aufkommenden Kapitalismus unabdingbare Einheit und Gleichheit ermöglichte. Die postmoderne Kritik unterstreicht, dass diese Ordnung nicht natürlich ist, sondern auf ein tatsächliches Chaos von Fragmenten aufgezwungen wurde. Theorien der Postmoderne betonen die Uneinigkeit und Künstlichkeit von Nationalstaaten. Es wird aufgezeigt, dass ein Nationalstaat aus vielen verschiedenen und sogar untereinander gegensätzlichen Gruppierungen besteht. Die einheitliche Identifikation der Bürger mit einem Nationalstaat basiert auf der Vorstellung einer andauernden, geteilten Geschichte, und einer Betonung von Gemeinsamkeiten und vermeintlichen Unterschieden gegenüber Anderen. Diese Vorstellung von Einigkeit und Gemeinsamkeit wird in der Postmoderne als Konstrukt enthüllt.
In ähnlicher Weise betonen postmoderne Theorien die Konstruiertheit der Vorstellung eines einheitlichen, wahren Selbst. Das Selbst wird empfunden als eine Ansammlung von zahlreichen, untereinander teilweise widerstreitenden, Teilen.
Die Entwicklung der Industrialisierung im Kapitalismus der Moderne führte zur Auflösung bestehender lokaler Strukturen, und somit zu einer Entwurzelung der Individuen. Am Ende des zwanzigsten Jahrhunderts verlangt der Konsumkapitalismus von den Menschen Mobilität und Wandelbarkeit. In dieser Phase der Globalisierung verlieren Nationalstaaten an Bedeutung. Persönliche Qualitäten wie Charakterstärke und Authentizität geraten in den Hintergrund, während die Fähigkeit zur Verstellung und ein hohes Maß an Flexibilität geachtet werden und Erfolg versprechen.
Diese Entwicklung bringt ein Gefühl des Verlustes mit sich, ein Gefühl von Heimatlosigkeit, Wurzellosigkeit, und Uneinigkeit mit sich selbst.
Die postmoderne nostalgische Sehnsucht nach einer idealisierten Vergangenheit basiert auf diesem Gefühl des Verlustes einer ehemaligen Einigkeit.
Die Besucher von Themenparks und heritage sites sehnen sich nach dem Erlebnis einer glorifizierten Vergangenheit, wobei die Authentizität der dargestellten Geschichte zweitrangig ist.
Julian Barnes und Brian Moore beschreiben die Errichtung und den Erfolg von Themenparks. Ungeachtet der Künstlichkeit der dargebotenen Shows und so mancher Ausstellungsstücke genießen postmoderne Besucher von Themenparks deren Hyperrealität, die ein Gefühl von Ganzheit und Einheit vermittelt.
Das erste Kapitel der Arbeit stellt zunächst die Gedankenwelt der Postmoderne dar. Die postmoderne Welt am Ende des zwanzigsten Jahrhunderts verlangt Mobilität, Anpassung, und Verstellung. Hierin gründet das Gefühl der Nostalgie nach Ganzheit und Zugehörigkeit, welches im zweiten Kapitel untersucht wird. Das dritte Kapitel ist der Struktur des Nationalstaates gewidmet, die in einem komplexen Zusammenspiel von Politik, Geschichte, und den Bedürfnissen der Gegenwart eine Möglichkeit der Identifikation darstellt, welche Ganzheit und Zugehörigkeit verspricht. Das vierte Kapitel zeigt, dass die Identifikation mit einem Nationalstaat auf der Vorstellung einer gemeinsamen Geschichte basiert, wie sie in Museen und heritage sites bewahrt und bestimmt wird, und wie sie durch die Ausübung – oder Einführung – von Traditionen gelebt wird.
Das fünfte Kapitel diskutiert den Zusammenhang zwischen Authentizität und Erschaffung, und zeigt, dass die Grenzen fließend sind, da seit jeher Traditionen und Gepflogenheiten zugunsten der Bedürfnisse der Gegenwart abgewandelt wurden. Julian Barnes und Brian Moore demonstrieren, dass in der Tourismusindustrie Authentizität an Wert verloren hat, da postmoderne Reisende, die an Simulationen gewöhnt sind, sich mit leichter erreichbaren Nachbildungen begnügen. Abschließend lässt sich feststellen, dass die Vorstellung einer ehemaligen Vollkommenheit und Heimat in der Vergangenheit der Auseinandersetzung mit den Bedürfnissen der Gegenwart im Wege steht. Dies äußert sich letztlich politisch, wie das gegenwärtig vorherrschende Misstrauen gegenüber supranationalen Strukturen wie der Europäischen Union zeigt.
We discuss deviations from the exponential decay law which occur when going beyond the BreitWigner distribution for an unstable state. In particular, we concentrate on an oscillating behavior, remisiscent of the Rabi-oscillations, in the short-time region. We propose that these oscillations can explain the socalled GSI anomaly, which measured superimposed oscillations on top of the exponential law for hydrogen-like nuclides decaying via electron-capture. Moreover, we discuss the possibility that the deviations from the Breit-Wigner in the case of the GSI anomaly are (predominantely) caused by the interaction of the unstable state with the measurement apparatus. The consequences of this scenario, such as the non-observation of oscillations in an analogous experiment perfromed at Berkley, are investigated.
Die Soziologin Carlotta Giustozzi hat sich in ihrer Dissertation mit den Folgen von Marginalisierung auf dem Arbeitsmarkt für soziale Teilhabe beschäftigt. Aus den Ergebnissen ihrer Arbeit hat sich unter anderem die Frage ergeben, inwiefern ein gesellschaftlicher Fokus auf Vollzeiterwerbsarbeit schädlich für Individuum und Gesellschaft sein können.
Every now and again, one is overcome by a sense of utter disbelief. How can it be that some conventional narratives are still so persistent and influential in this day and age? In fact, they are so pervasive that one feels compelled to put pen to paper in order to combat them. Among these narratives, we find the tale of cultural evolution, where law plays a fundamental role as an instrument for rationalizing archaic societies. Having rejected this kind of historiography in his last essay on the early history of law (ZRG RA 127, 1–13), the late Raymond Westbrook instead postulated new paradigms. Moving in the same direction, Philipp Ruch thwarts this story of civilizing progress in a twofold manner: In his eyes, honor and vengeance are not the anthropological factors that law has to contain in order to create civilization. According to Ruch, and the main thrust of his 2016 dissertation, it was in fact law in the context of honor and vengeance that produced emotionality. ...
(Neu-)Start in die akademische Ausbildung : Academic Welcome Program feierte erste Absolventen
(2017)
Am 20. April beginnt der lang erwartete Prozess gegen die Führungsriege und Mitglieder der sog. Sturmtruppen der griechischen Goldenen Morgenröte (Χρυσή Αυγή – XA). Insgesamt 69 Angeklagte müssen sich für die Bildung bzw. die Mitgliedschaft in einer kriminellen Organisation verantworten. Es stehen Anklagepunkte wie Mord, Körperverletzung, Bestechung und Schutzgelderpressung im Raum. Trotz der deutlichen Ausgangslage liegen die konkreten Organisationsstrukturen weithin im Dunkeln, wodurch eine Rädelsführerschaft schwer nachzuweisen ist. Andererseits wird der Prozess auch Verbindungen in den ‚politischen Mainstream‘ deutlicher machen als es manchem Akteur lieb sein wird, was wiederum neue Herausforderungen für die Unabhängigkeit des Verfahrens mit sich bringt...
Die Schlagzeilen verdeutlichen: Wölfe lösen beim Menschen gleichermaßen Angst und Faszination aus. Das Raubtier wird bei Nutztierhaltern, Jägern, Naturschützern und Politikern kontrovers diskutiert. Die Wolfspopulation wächst in Deutschland zurzeit um etwa 30 Prozent pro Jahr und die Anzahl der vom Wolf gerissenen Tiere nimmt zu. Das »Rotkäppchen-Syndrom« ist tief in unseren Wertevorstellungen verankert. Doch was ist dran am Mythos "böser Wolf"?
Starting from (MeO)3SiCH2Cl (10) and Ph2(H)SiCH2OH (16), respectively, the (hydroxymethyl)diphenyl(piperidinoalkyl)silanes (HOCH2)Ph2Si(CH2)2NC5H10 (6) and (HOCH2)Ph2Si(CH2)3NC5H10 (8) have been synthesized [10→Ph2(MeO)SiCH2Cl (11)→Ph2(CH2=CH)SiCH2Cl (12)→Ph2(CH2=CH)SiCH2OAc (13)→Ph2(CH2=CH)SiCH2OH (14)→Ph2(CH2=CH)SiCH2OSiMe3 (15)→6; 16→Ph2(H)SiCH2OSiMe3 (17)→8; NC5H10 = piperidino]. N-Quaternization of 6 and 8 with MeI gave the corresponding methiodides 7 and 9, respectively. As shown by IR-spectroscopic studies, compounds 6 and 8 form intramolecular O-H···N hydrogen bonds in solution (CCl4). In the crystal, 6 (space group Pna21; two crystallographically independent molecules) also forms intramolecular O-H···N hydrogen bonds whereas 8 (space group P1̅) forms intermolecular O-H···N hydrogen bonds leading to the formation of centrosymmetric dimers (single-crystal X-ray diffraction studies). The (hydroxymethyl) silanes 6-9 and the related silanols (HO)Ph2Si(CH2)2NC5H 10 (sila-pridinol; 1), sila-pridinol methiodide (2), (HO)Ph2Si(CH2)3NC5H10 (sila-difenidol; 3) and sila-difenidol methiodide (4) were investigated for their antimuscarinic properties. In functional pharmacological experiments as well as in radioligand competition studies, all compounds behaved as simple competitive antagonists at muscarinic M1-, M2-, M3- and M4-receptors. In general, the silanols 1-4 displayed higher receptor affinities (up to 100-fold) than the corresponding (hydroxymethyl) silanes 6-9 . In the (hydroxymethyl)silane series, compound 7 was found to be the most potent muscarinic antagonist [pA2/pKi= 8,71/8,6 (M1), 8,23/7,8 (M2), 8,19/7,8 (M3); pKi = 8,2 (M4)]. In the silanol series, the related compound 2 showed the most interesting antimuscarinic properties [pA2/pKi = 10,37/9,6 (M1), 8,97/8,8 (M2), 9,08/8,8 (M3); pKi = 9,4 (M4)].
In the crystal of the title compound, C8H8ClN3S, molecules are connected by N—H[cdots, three dots, centered]S hydrogen bonds into strips parallel to the (112) planes and running along [110]. One of the amino H atoms is not involved in a classical hydrogen bond. In addition, there is a rather short intermolecular Cl ... S distance of 3.3814 (5) Å.
In August 1945 during the late Pacific War the U.S. dropped two atomic bombs on Japanese cities. A traditional view of the event suggests that the bombs had no other function then to force Japan’s surrender, thus ending the war. Not long after the war, the former anti-axis coalition confronted each other in the Cold War, but even before that, a potential conflict had been obvious. Based on diplomatic, military and political primary sources and in recognition of the most recent academic literature this study reveals the degree to which the implications of the atomic bomb strikes were based on anti-soviet motivation. The analysis shows that even before the first bomb test, American government officials, especially Secretary of State Byrnes, had envisioned the weapon as a diplomatic lever in dealing with the difficult Soviet ally. However, the tested bomb in their hand proved to surpass all their expectations. Wiping out several Japanese cities would display the power of the weapon in a spectacular way, de-livering a psychological doomsday message. In this way it promised to fulfill several diplo-matic goals at once: on the one hand speeding up the Japanese surrender and on the other hand, in an act of Realpolitik, giving the Soviets a powerful impression of America’s political and military might. During the Potsdam Conference in July 1945 the U.S. acted accordingly. Stalin, who already knew details of the atomic project from his spies, felt betrayed by the U.S. and regarded their behavior as atomic blackmail. In conclusion, the analysis points out that the atomic bomb, although it was released over Japan, was also intended to send a message to Moscow. The decision of its use wasn’t exclusively influenced by anti-soviet diplomatic purposes, but it ended up shaping the passage into the Cold War.
The ALICE detector is ideally suited to study the production of anti- and hyper-matter due to its excellent particle identification capabilities. The measurement of the He¯4-nucleus in Pb–Pb collisons at sNN=2.76TeV is presented. We further show the performance for the reconstruction of the (anti-)hypertriton in the decay to He3+π− (He¯3+π+). In addition to this, two searches have been performed, one for the H-Dibaryon →Λpπ− and one for the Λn bound state (Λn¯→d¯π+). No signals are observed for these exotic states and upper limits have been determined.
The study of (anti-)deuteron production in pp collisions has proven to be a powerful tool to investigate the formation mechanism of loosely bound states in high-energy hadronic collisions. In this paper the production of (anti-)deuterons is studied as a function of the charged particle multiplicity in inelastic pp collisions at s√=13 TeV using the ALICE experiment. Thanks to the large number of accumulated minimum bias events, it has been possible to measure (anti-)deuteron production in pp collisions up to the same charged particle multiplicity (dNch/dη∼26) as measured in p–Pb collisions at similar centre-of-mass energies. Within the uncertainties, the deuteron yield in pp collisions resembles the one in p–Pb interactions, suggesting a common formation mechanism behind the production of light nuclei in hadronic interactions. In this context the measurements are compared with the expectations of coalescence and statistical hadronisation models (SHM).
The study of (anti-)deuteron production in pp collisions has proven to be a powerful tool to investigate the formation mechanism of loosely bound states in high energy hadronic collisions. In this paper the production of (anti-)deuterons is studied as a function of the charged particle multiplicity in inelastic pp collisions at s√=13 TeV using the ALICE experiment. Thanks to the large number of accumulated minimum bias events, it has been possible to measure (anti-)deuteron production in pp collisions up to the same charged particle multiplicity (dNch/dη∼26) as measured in p-Pb collisions at similar centre-of-mass energies. Within the uncertainties, the deuteron yield in pp collisions resembles the one in p-Pb interactions, suggesting a common formation mechanism behind the production of light nuclei in hadronic interactions. In this context the measurements are compared with the expectations of coalescence and Statistical Hadronisation Models (SHM).
The study of (anti-)deuteron production in pp collisions has proven to be a powerful tool to investigate the formation mechanism of loosely bound states in high energy hadronic collisions. In this paper the production of (anti-)deuterons is studied as a function of the charged particle multiplicity in inelastic pp collisions at s√=13 TeV using the ALICE experiment. Thanks to the large accumulated integrated luminosity, it has been possible to measure (anti-)deuteron production in pp collisions up to the same charged particle multiplicity (dNch/dη∼26) as measured in p-Pb collisions at similar centre-of-mass energies. Within the uncertainties, the deuteron yield in pp collisions resembles the one in p-Pb interactions, suggesting a common formation mechanism behind the production of light nuclei in hadronic interactions. In this context the measurements are compared with the expectations of coalescence and Statistical Hadronisation Models (SHM).
The IrIII atom of the title compound, [Ir(C11H8N)2Cl(CH3CN)], displays a distorted octahedral coordination. The pyridyl groups are in trans positions [N—Ir—N = 173.07 (10)°], while the phenyl groups are trans with respect to the acetonitrile and chloride groups [C—Ir—N = 178.13 (11) and C—Ir—Cl = 176.22 (9)°]. The pyridylphenyl groups only show a small deviation from planarity, with the dihedral angle between the planes of the two six-membered rings in each pyridylphenyl group being 5.6 (2) and 5.8 (1)°. The crystal packing shows intermolecular C—H[cdots, three dots, centered]Cl, C—H[cdots, three dots, centered]π(acetonitrile) and C—H[cdots, three dots, centered]π(pyridylphenyl) contacts.
The title compound, C26H18BrNO4, features a functionalized chromene. The cyclohexene ring adopts a sofa conformation and has the nitro group and the bromophenyl ring in an axial position. The ten atoms of the chromene moiety lie close to a common plane (r.m.s. deviation = 0.066 Å). The attached phenyl ring is twisted by 32.89 (10)° from the chromene plane. The crystal packing is stabilized by C—H[cdots, three dots, centered]O interactions.
The title compound, C15H15BrO2, was synthesized by a Brønsted acid-catalysed domino electrocyclization-halogenation reaction. The five-membered ring is essentially planar (r.m.s. deviation 0.006 Å) and forms a dihedral angle of 72.7 (3)° with the attached phenyl ring. The six-membered heterocycle adopts a half-chair conformation. The crystal packing is stabilized by a C—H[cdots, three dots, centered]O contact.
The title compound, C(21)H(18)ClN, was synthesized by an enanti-oselective Brønsted acid-catalysed transfer hydrogenation reaction. The six-membered heterocycle adopts a half-chair conformation. It has the biphenyl residue in an axial position. The two rings of the biphenyl residue are almost coplanar [dihedral angle = 2.65 (9)°]. The crystal packing is stabilized by N-H⋯Cl hydrogen bonds, which connect the mol-ecules into chains running along the a axis.
Molecules of the title compound, C20H14O2, show approximate C s symmetry with the approximate mirror plane perpendicular to the central ring. The torsion angles about the acyclic bonds are 30.05 (15) and 30.77 (15)° in one half compared to −36.62 (14) and −18.60 (15)° in the other half of the molecule. The central aromatic ring makes dihedral angles of 47.78 (4) and 51.68 (3)° with the two terminal rings.
The title compound (also know as azorellanone), C20H32O2, is built up from three fused carbocycles, one five-membered ring and two six-membered rings. The five membered-ring has an envelope conformation, whereas the six-membered rings have a distorted half-chair and a twist–boat conformation. In the crystal, molecules are linked by O—H ... O interactions into zigzag chains with graph-set notation C(8) along [010]. The absolute configuration was assigned on the basis of earlier chemical studies.
The title compound, C(19)H(14)ClNO(3)·0.2H(2)O, crystallizes with five mol-ecules and a disordered water mol-ecule in the asymmetric unit. Four of the five mol-ecules form hydrogen-bonded dimers via N-H⋯O hydrogen bonds towards another symmetry-independent mol-ecule, whereas the fifth mol-ecule forms a hydrogen-bonded dimer with its symmetry equivalent, also via N-H⋯O hydrogen bonds. The dihedral angle between the planes of the fused benzene ring and the five-membered ring to which it is attached is 79.45 (13), 49.00 (15), 72.49 (16), 81.91 (18) and 76.38 (16)° for the five mol-ecules in the asymmetric unit.
The title compound, [Na(CF3O3S)(C12H24O6)], features a sodium cation that is coordinated by eight O atoms in an irregular hexagonal bipyramidal environment. The equatorial positions are occupied by the six O atoms of an 18-crown-6 ether ring. In the axial positions, there is one O atom of a trifluoromethanesulfonate anion and an ether O atom of a symmetry-equivalent crown ether ring. In this way, centrosymmetric dimers are formed.
'Блаженный человек' и 'старый Бог' : Эссе о ницшеанском апокалипсисе современного существования
(2015)
"Wohin ist Gott? rief er, ich will es euch sagen! Wir haben ihn getödtet, - ihr und ich! Wir alle sind seine Mörder!" Diese berühmten Sätze des 'tollen Menschen' aus Friedrich Nietzsches Werk 'Die Fröhliche Wissenschaft' sind keineswegs an bekennende Fromme gerichtet, um sie von ihrem Gottesglauben abzubringen und vom Atheismus zu überzeugen. Sein entsetzter Ausruf richtet sich vielmehr an die Atheisten oder sonstige Ungläubige. Aber diesen Ausruf tat er auch nicht, um sie in ihrem wissenschaftlichen oder unwissenschaftlichen Unglauben zu bestärken. Nein! Er ruft ihnen diese schier unglaubliche Wahrheit zu, um sie mit der Frage zu konfrontieren, ob sie, die Gott getötet haben, überhaupt wissen, was sie angerichtet haben, ob sie sich der Konsequenz ihrer ungeheuerlichen Tat bewußt sind.Der 'tolle Mensch' distanziert sich dabei keineswegs von seinen gottlosen Zuhörern; im Gegenteil: ausdrücklich rechnet er sich ihnen zu. Aber im Gegensatz zu den angeredeten Gottesmördern hat er begriffen, was für eine furchtbare Existenzkatastrophe sie gemeinsam heraufbeschworen haben.
Wer ist aber dieser Gott, den Nietzsche den 'alten Gott' nennt, und den er, der 'tolle Mensch' und seine Zuhörer auf dem Marktplatz der Moderne getötet haben?
The Muskoka Initiative – or the Maternal, Newborn and Child Health (MNCH) Initiative has been a flagship foreign policy strategy of the Harper Conservatives since it was introduced in 2010. However, the maternal health initiative has been met with a number of key criticisms in relation to its failure to address the sexual and reproductive health needs of women in the Global South2. In this article, I examine these criticisms and expose the prevalent and problematic discourse employed in Canadian policy papers and official government speeches pertaining to the MNCH Initiative. I examine the embodiment of the MNCH and how these references to women’s bodies as “walking wombs” facilitate: the objectification and ‘othering’ of women as mothers and childbearers; a discourse of ‘saving mothers’ in a paternalistic and essentialist language; and the purposeful omission of gender equality. Feminist International Relations (IR) and post-colonial literature, as well as critical/feminist Canadian foreign policy scholarship are employed in this paper to frame these critiques.
'THIS ISN'T ME!': the role of age-related self- and user images for robot acceptance by elders
(2020)
Although companion-type robots are already commercially available, little interest has been taken in identifying reasons for inter-individual differences in their acceptance. Elders’ age-related perceptions of both their own self (self-image) and of the general older robot user (user image) could play a relevant role in this context. Since little is known to date about elders’ companion-type robot user image, it is one aim of this study to investigate its age-related facets, concentrating on possibly stigmatizing perceptions of elder robot users. The study also addresses the association between elders’ age-related self-image and robot acceptance: Is the association independent of the user image or not? To investigate these research questions, N = 28 adults aged 63 years and older were introduced to the companion-type robot Pleo. Afterwards, several markers of robot acceptance were assessed. Actual and ideal self- and subjective robot user image were assessed by a study-specific semantic differential on the stereotype dimensions of warmth and competence. Results show that participants tended to stigmatize elder robot users. The self-images were not directly related to robot acceptance, but affected it in the context of the user image. A higher fit between self- and user image was associated with higher perceived usefulness, social acceptance, and intention to use the robot. To conclude, elders’ subjective interpretations of new technologies play a relevant role for their acceptance. Together with elders’ individual self-images, they need to be considered in both robot development and implementation. Future research should consider that associations between user characteristics and robot acceptance by elders can be complex and easily overlooked.
The internet has often been considered a 'technology of freedom' – a nearly revolutionary tool believed to flatten social hierarchies and democratize access to media by 'giving voice' to everybody equally. Contradictory to this point of view, research has shown the existence of a 'digital divide,' the phenomenon that access to and use of the internet, as well as the outcomes derived from this use, correlate with pre-existing inequalities.
Based on ethnographic fieldwork among activists in Dakar, Senegal, this thesis analyzes how inequalities shape and are shaped by the relationships between activists and smartphones. Do smartphones indeed flatten social hierarchies, or are inequalities rather reproduced – or even reinforced – through them?
'Skelettfund' im Keller
(2021)
Bei der Identifizierung einer unbekannten, stark verwesten Leiche oder eines Skelettes ohne Hinweise auf die Identität durch die Auffindesituation spielt die Erstellung des sog. biologischen Profils eine entscheidende Rolle. Vorgestellt wird ein Leichenfund in einem mehr oder weniger frei zugänglichen Kellerabteil eines Mehrfamilienhauses. Der Leichnam war weitgehend skelettiert, das Skelett jedoch durch mumifizierte Weichteilreste noch nahezu vollständig zusammengehalten. Bei den Hinweisen auf die Identität ergaben sich insbesondere in der Altersschätzung scheinbare Widersprüche, die jedoch zufällig eine relativ genau zutreffende Schätzung lieferten. Die Überreste konnten mittels forensischer DNA-Analyse einer seit 4 Jahren vermissten 49-Jährigen zugeordnet werden. Als Todesursache wurde ein Kältetod diskutiert.
Der Fall wies eine außergewöhnliche Auffindesituation auf, die an Bilder von „Skelettfunden“ in Kriminalverfilmungen erinnerte. Derartige Befunde dürften jedoch in der Realität wohl nur sehr selten vorkommen. Darüber hinaus werden die Wichtigkeit und die Probleme der forensisch-osteologischen Untersuchungen bei der Identifizierung eines stark verwesten, unbekannten Leichnams demonstriert.
n this paper we analyze an economy with two heterogeneous investors who both exhibit misspecified filtering models for the unobservable expected growth rate of the aggregated dividend. A key result of our analysis with respect to long-run investor survival is that there are degrees of model misspecification on the part of one investor for which there is no compensation by the other investor's deficiency. The main finding with respect to the asset pricing properties of our model is that the two dimensions of asset pricing and survival are basically independent. In scenarios when the investors are more similar with respect to their expected consumption shares, return volatilities can nevertheless be higher than in cases when they are very different.
Downy mildews caused by obligate biotrophic oomycetes result in severe crop losses worldwide. Among these pathogens, Pseudoperonospora cubensis and P. humuli, two closely related oomycetes, adversely affect cucurbits and hop, respectively. Discordant hypotheses concerning their taxonomic relationships have been proposed based on host–pathogen interactions and specificity evidence and gene sequences of a few individuals, but population genetics evidence supporting these scenarios is missing. Furthermore, nuclear and mitochondrial regions of both pathogens have been analyzed using microsatellites and phylogenetically informative molecular markers, but extensive comparative population genetics research has not been done. Here, we genotyped 138 current and historical herbarium specimens of those two taxa using microsatellites (SSRs). Our goals were to assess genetic diversity and spatial distribution, to infer the evolutionary history of P. cubensis and P. humuli, and to visualize genome-scale organizational relationship between both pathogens. High genetic diversity, modest gene flow, and presence of population structure, particularly in P. cubensis, were observed. When tested for cross-amplification, 20 out of 27 P. cubensis-derived gSSRs cross-amplified DNA of P. humuli individuals, but few amplified DNA of downy mildew pathogens from related genera. Collectively, our analyses provided a definite argument for the hypothesis that both pathogens are distinct species, and suggested further speciation in the P. cubensis complex.
Background: To investigate patients’ perspectives on polypharmacy and the use of a digital decision support system to assist general practitioners (GPs) in performing medication reviews. Methods: Qualitative interviews with patients or informal caregivers recruited from participants in a cluster-randomized controlled clinical trial (cRCT). The interviews were transcribed verbatim and analyzed using thematic analysis. Results: We conducted 13 interviews and identified the following seven themes: the patients successfully integrated medication use in their everyday lives, used medication plans, had both good and bad personal experiences with their drugs, regarded their healthcare providers as the main source of medication-related information, discussed medication changes with their GPs, had trusting relationships with them, and viewed the use of digital decision support tools for medication reviews positively. No unwanted adverse effects were reported. Conclusions: Despite drug-related problems, patients appeared to cope well with their medications. They also trusted their GPs, despite acknowledging polypharmacy to be a complex field for them. The use of a digital support system was appreciated and linked to the hope that reasons for selecting specific medication regimens would become more comprehensible. Further research with a more diverse sampling might add more patient perspectives.
This article is directed towards addressing the employment related issues encountered by female workers in the gig economy in the EU. It revolves around analysing ‘the switch’ from the traditional labour market to the platform economy. It subsequently explains, by drawing comparisons, that the issues of gender inequality in the brick and mortar world are still prevalent in world of the digital platform. In fact, new challenges have emerged which are specifically related to the gig economy. Female workers are now affected by the inherent bias of algorithms. Moreover, due to the unequivocal propagation of ‘flexibility’ which is used as a weapon to glorify the gig economy; women are even more likely to be pushed into precarious work. The other prominent issues of gender inequality like the dynamics of intersectionality, the gender pay gap and hiring policies in traditional and digital platforms are also examined. Furthermore, the existing regulatory frameworks addressing these issues are discussed with the possibility of catering to the gender inequality issues in the gig economy through policy development. The article concludes with a reflection on the need for the EU to take immediate and efficacious policy measures in respect of female workers in the gig economy.
My study examined MMA training, and thereby the ‘back region’ of MMA, where the ‘everyday life’ of MMA takes place. I enquired into how MMA training corresponds with MMA’s self-description, namely the somehow self-contradicting notion that MMA fights would be dangerous combative goings-on of approximately real fighting, but that MMA fighters would be able to approach these incalculable and uncontrolla-ble combative dangers as calculable and controllable risks.235 Conducting an ethnog-raphy in which I focused on the combination of participation and observation, I stud-ied how the specific interaction organisations of the three core training practices of MMA training provide the training students with specific combative experiences and how they thereby construct the social reality that is MMA training....
This article departs from the hypothesis that Alexander von Humboldt used ‘Big Data’ in order to bring new scientific evidence into the open. His method of measuring and combining temperature, humidity, altitude and magnetism in a geographical environment must be regarded as innovative, indeed, as the foundation of modern science. Although Humboldt lived in an analogue world and used the instruments of his time, his way of assembling information was not so different from what we are seeing in today's digitalised world. Information has no value unless it is shared. It does not say anything unless it is linked with other data. It cannot remain isolated but must be compared and interpreted. The generation of ʻBig Dataʼ was a pathway to Humboldt's concept of ʻKosmosʼ in much the same way as ʻBig Dataʼ today is the pathway to a virtual world. In this sense, Humboldt not only laid the foundation of modern science but anticipated the existence of a world where data and information are the source of everything when it comes to understanding the interconnectivity of the physical and the virtual world.
Eigentlich sollte es bei der heutigen Pressekonferenz in London um das neue technische System der Plattform gehen – SSL sei nicht mehr sicher, man bastele an einem „state-of-the-art secure submission system“, hieß es. Doch davon war auf der Pressekonferenz keine Rede mehr. Stattdessen wurde die „neue Phase“ von WikiLeaks mit einer neuen Veröffentlichung eingeleitet: den #SpyFiles...
Die deutsche Bevölkerung lernt in regelmäßigen Abständen, aber wohl dosiert, die von der Bundeswehr verwendeten Waffensysteme kennen. Für gewöhnlich nämlich dann, wenn es Aufregung um ein bestimmtes System gibt. In den 1960ern waren dies der Starfighter, der über 160 Piloten das Leben kostete, und U-Boote, deren Stahl kein Salzwasser vertrug. In den 1980ern/1990ern entpuppte sich der Jäger 90, der heute Eurofighter heißt, als Paradebeispiel der Stückkostensteigerung. In jüngerer Vergangenheit lernten wir u.a. kennen: das IT-Projekt Herkules, das sämtliche Vorurteile bestätigt, die man über IT-Projekte zu haben pflegt; den Kampfpanzer Leopard, der in autoritäre Staaten exportiert werden soll(te); den militärischen Großraumtransporter A400M, der bei einem Testflug im Mai 2015 abstürzte und dessen Entwicklung ohnehin schon von vielen Pannen gekennzeichnet war; die Aufklärungsdrohne Euro Hawk, deren Entwicklung massive Mehrkosten drohten – ohne dass Aussicht auf Zulassung für den deutschen Flugraum bestand; und natürlich ganz aktuell das im heißgeschossenen Zustand unpräzise Sturmgewehr G-36. Ob es bei letzterem ebenso wie beim Euro Hawk zu einem Untersuchungsausschuss kommen wird, hängt allein von der Linken ab...
Last week, this year’s ISA conference brought together over 5000 scholars and exhibitors from all over the world to discuss all things international, political, scholarly, hold meetings, get lunch together, and party at Mardi Gras (it was in New Orleans, after all!). Similar to last year, a lot of this discussing took also place on Twitter. Scholars-slash-tweeps rallied around the hashtag #isa2015 to talk to each other online about great (and not so great) panels, trends in IR scholarship, gender bias in academia, and (not surprisingly for an academic conference) coffee. Who was most active during ISA2015 on Twitter? What were the most hotly debated topics online? When did ISAlers tweet?
Die Arbeit befasst sich auf dem Weg einer qualitativ empirischen Studie mit dem Thema „informelles Lernen“. Im Mittelpunkt steht die Erforschung der unterschiedlichen Phänomene informellen Lernens – der Lerninhalte, -formen und -modalitäten sowie die Bedeutung des Kontextes für diese Lernform. Darüber hinaus wird auf einer theoretischen Ebene eine Auseinandersetzung mit dem Diskurs um das informelle Lernen angestrebt. Neben einem Literaturbericht – dessen Ergebnis die theoretische wie empirische Unterbelichtung des informellen Lernens ist – wird nach einem systematischen Verständnis vom Lernen in informellen Kontexten gesucht. Im Fokus der Arbeit liegt aber die empirische Befassung mit dem Phänomen des informellen Lernens. Zu diesem Zweck wurden – verortet im Kontext eines kommunalen Wildtiermanagementprojektes – zweistufige Interviews sowie teilnehmende Beobachtungen durchgeführt und analysiert. Auf Basis dieser empirischen Daten konnten unterschiedliche Lernergebnisse und -formen informellen Lernens sowie unterschiedliche lernrelevante (Kontext-)Faktoren rekonstruiert werden. Darüber wurden spezifische Merkmale und Besonderheiten des Lernens in informellen Kontexten erarbeitet.
Wenn Rechtstexte auf literarische Texte treffen, dann treffen Wahrheitsformen aufeinander. Es treffen unterschiedliche Weisen, Wahrheit zu produzieren, aufeinander. Zu den zahlreichen Unterschieden gehören, historisch bedingt, unterschiedliche Stile, die sich um die Objektivierung und "Subjektivierung" der Aussagen bilden. Das fängt bei den banalen "wir" und "man" rechtswissenschaftlicher Texte an, geht über allgemein gehaltene, enthistorisierende und systematisierende Definitionen bis zu einem Fussnotenapparat, der in manchen Rechtstexten beinahe jede Aussage als nachweisbare Aussage absichern soll. Die Rechtswissenschaft, zumal die deutsche, pflegt bei ihren Wahrheitsformen objektivierende Stile, die Literaturwissenschaft tut das nicht, nicht in dem Maße, sie lässt das Subjekt stärker in die Aussage einbrechen. Die Lage zwischen diesen beiden Disziplinen ist allerdings kompliziert, weil wiederum das Recht eine wirksame Subjektivierungsinstanz ist, die eben die Instrumente zur Verfügung stellt, um Aussagen an Subjekte zu binden. Sie hat die Unterschrift und den Urheber erfunden. In dieser Lage kann man also nicht einfach das Subjektive gegen das Objektive ausspielen. Von Anfang aber über das Zusammentreffen von Literatur und Recht in objektivierenden Stilen zu schreiben, schafft eine asymmetrische Ausgangslage, die ich gerne zugunsten einer symmetrischen Ausgangslage umgehen möchte – soweit das möglich ist. ...
Der Befehl des Kaisers Caligula an seine an der Nordseeküste versammelte Truppe, Muscheln zu sammeln statt zur erwarteten oder auch befürchteten Expedition nach Britannien aufzubrechen, scheint sich aufs Beste einzufügen in die zahlreichen Eskapaden, Willkürmaßnahmen und unkontrollierten Verhaltensweisen des im Frühjahr 37 n. Chr. mit kaum 25 Jahren als Nachfolger des Tiberius zur Herrschaft gelangten Kaisers.1 Die Nachricht findet sich zuerst bei dem nie um eine sensationelle Mitteilung aus dem Leben römischer Kaiser verlegenen Sueton in seiner im früheren 2. Jh. n. Chr. verfassten Biographie des C. Caesar Germanicus (Suet., Cal. 46), allenthalben bekannt als Gaius oder eben Caligula ("Soldatenstiefelchen"). Diesen Spitznamen hatten die Rheinlegionen für den als Kleinkind im Heer des Germanicus mitziehenden Sohn des Befehlshabers erdacht. ...
"Ästhetisch ist, was hilft"
(2017)
Träge und arbeitsscheu ist der römische Gesandte, den Francesco Vettori am 23. November 1513 Niccolò Machiavelli gegenüber skizziert – ein Mann, der lieber schmökernd in der Stube sitzt, sich mit Freunden tummelt oder mit Mädchen von zweifelhaftem Ruf vergnügt und der nicht daran denkt, den Austausch mit anderen Gesandten zu pflegen oder überhaupt wichtige Leute zu treffen. Und wenn er doch einmal zur Feder greift, berichtet er keine brisanten Details über politische Entwicklungen, liefert keine scharfsinnigen Analysen der gegenwärtigen Situation, sondern füllt seine Briefe mit Belanglosigkeiten, die der schlichten Erheiterung des Lesers dienen. Der Mann, über den Francesco Vettori dies berichtet, ist er vermeintlich selbst. Das satirische Selbstportrait, das der Gesandte an der Kurie in Rom augenzwinkernd von sich entwirft, zeigt deutlich, dass zu Beginn des 16. Jahrhunderts bereits eine Reihe recht klarer Vorstellungen existierte, wer oder was ein Gesandter zu sein hatte, welchen Normen er folgen musste und vor allem, was er leisten sollte. Und die Verfestigung dieser Vorstellungen war eben einhergegangen mit der Ausbildung eines ständigen Gesandtenwesens, dessen nähere Betrachtung in Rom besonders spannend zu sein verspricht, da die Kurie zwar in mancher Hinsicht ein typisch europäischer Hof war, während sie in manch anderer Hinsicht aber, durch die besondere spirituelle und rechtliche Rolle des universalen Kirchenoberhauptes, auch atypisch war und nicht ihresgleichen kannte. Hier, in diesem "'supranational' centre for European diplomacy" (105), wo sich mehr Gesandte als an allen anderen europäischen Höfen aufhielten, war das Ringen um Benefizien besonders ausgeprägt, war das liturgische Zeremoniell mehr als anderswo ausgebildet; hier in diesem "international gossip shop" (105) flossen besonders viele Informationen zusammen, trafen Normen aller Art aufeinander. In diesem Schmelztiegel kamen viele diplomatische Praktiken miteinander in Berührung, wurden fusioniert und fortentwickelt. ...
While Freud regularly discusses the Oedipus complex in the context of the Sophoclean tragedy, the founding document of the psychoanalytic theory of narcissism lacks any trace of the mythological substrate. Both Narcissus, who contributed no less than his name to the psychic phenomenon of narcissism, and Ovid, in whose Metamorphoses the most elaborate and effective elaboration of the myth of Narcissus is laid down, form a conspicuous blank space in Freud's 'Introduction to Narcissism'. This article will attempt to explain this lack of tradition and, in addition, discuss the figure of Pygmalion as a productive form of narcissism that can supplement Freud's theory.
Als »Institut für Afrikanische Sprachwissenschaften« gegründet, hat sich die Afrikanistik im Spektrum des linguistischen Angebots an der Goethe-Universität inzwischen fest etabliert. Ein Gespräch zwischen Antonia Fendt und Mary Ann McLaughlin, zwei Studentinnen der Afrikanistik, und dem Doyen des Fachs, Prof. Herrmann Jungraithmayr. Dr. Anke Sauter hat die Runde moderiert.
Let me start with a reminiscence: a few weeks ago, I was sitting in one of my preferred cafés in Paris, le Café Odéon- Théâtre de l’Europe, a vivid place near the Jardin de Luxembourg in the heart of the university quarter. I realised that the waiter was wearing a shirt with the letters "Defend Paris", which he explained to be a statement against the forces that make Paris an uneasy place to live, a defiance against the powerful and social injustice. With a mixture of rebellion and idealism, he added that he understands himself as part of a "Reclaim Your City" Movement, thus representing what is central for urban citizenship today: a republican defence against forces that make a metropolitan city a trademark to be sold to people who can afford it, but increasingly less a home for ordinary people who want to live in the city. Walking through the streets, passing a small jewelry shop, a place of distinguished understatement showing a picture of Meghan Markle wearing "rose"-earrings displayed in the window, the term "zombie urbanism" came to my mind – a term used by Jonny Aspen, professor at the Institute of Urbanism and Landscape in Oslo (See Bjerkeset and Aspen (forthcoming 2020) and here), to describe a cliché-like way of dealing with urban environment by developers and designers – a "staged urbanism", in which urban features are used as a means for selling, marketing and branding. This kind of city-marketing can prove quite successful: whereas the burning of Notre Dame mobilised hundreds of millions of donations within a short period of time, the burning of the National Museum in Rio de Janeiro soon after, extinguishing 200 years of documentation of cultural memory, mobilised only 225.000 Euros (state 1.4.2019). ...
Die HAART hat einen Durchbruch in der Therapie der HIV-Infektion bewirkt und so zu einer drastischen Senkung der Mortalität und Morbidität geführt. Um diesen Ansprüchen weiterhin gerecht zu werden und sie bestenfalls zu übertreffen, erfordert eine ständige Weiterentwicklung der HAART mit neuen und ausgefeilteren Alternativen. Ein weiterer Schritt in diese Richtung ist die Entwicklung einer neuen Formulierung des Kombinationspräparates LPV/r (Kaletra®) von der „lipophilen Kapselform“ zur „hydrophilen Tablettenform“, aus der Wirkstoffgruppe der Proteasehemmer. Lopinavir (LPV) ist ein HIV-Proteasehemmer der mit Ritonavir (r oder RTV) als fixe Kombination (LPV/r) hergestellt wird. Der Proteasehemmer Ritonavir wird dabei in subtherapeutischer Dosierung als Booster verwendet, dadurch wird eine Verbesserung der pharmakokinetischen Eigenschaften erzielt. Der Vorteil hierbei sind die höheren Lopinavir-Plasmaspiegel die erreicht werden. Diese Kombination wird als Kaletra® (LPV/r) vermarktet.
LPV/r ist erhältlich als lipophile Kapselform (133,3/33,3mg) oder in Flüssigform (80/20mg pro ml). Beide erfordern eine kühle Lagerung und müssen mit einer fettreichen Mahlzeit eingenommen werden, um optimale Lopinavir Plasmaspiegel zu erzielen.
Durch das „Melt Extrusion (Meltrex)“ Produktionsverfahren gelang die Herstellung einer „hydrophilen Tabletteform“ (200/50mg und 100/25mg) mit verbesserter Bioverfügbarkeit. Dadurch reduzierte sich die einzunehmende Anzahl von 6 Kapseln pro Tag auf 4 Tabletten pro Tag. Zudem bedarf die LPV/r Tablette keiner Kühlung und kann nahrungsunabhängig eingenommen werden.
Ziel dieser Untersuchung war es zu prüfen, welche LPV/r (Kaletra®) Darreichungsform, Kapsel oder Tablette, in einer HAART von HIV-Patienten bevorzugt wird. Es sollte ermittelt werden, ob bei gleichbleibender Wirksamkeit kombiniert mit einer verbesserten Verträglichkeit und Handhabung (weniger Tabletten, nahrungsunabhängige Einnahme und keine Kühlung), die überwiegende Mehrzahl der HIV-Patienten sich zugunsten der LPV/r Tablette, im Sinne einer verbesserten Lebensqualität bzw. Gemütszustandes, entscheiden werden.
Dies geschah anhand einer prospektiven, nicht randomisierten Studie mit 238 HIV-infizierten Patienten, die über mindesten 16 Wochen oder länger eine LPV/r Kapsel haltige antiretrovirale Kombinationstherapie einnahmen und am Tag 0 auf LPV/r Tabletten umgestellt wurden, ohne weitere Änderungen in ihrer bisherigen HAART vorzunehmen. Der darauffolgende Beobachtungszeitraum betrug 32 Wochen. Es wurden Vorher-, Nachher-Fragebogen ausgefüllt und die Patienten unterzogen sich einer Vorher-, Nachher-Laboruntersuchung (CD4 und HI-Viruslast). Zudem wurde nach der subjektiven Präferenz gegenüber beiden Darreichungsformen (Kapsel oder Tablette) gefragt.
Zusammenfassend lässt sich sagen, dass unter der LPV/r Tablette bei gleichbleibender antiretroviraler Wirksamkeit, signifikant weniger intestinale Nebenwirkungen auftraten und daran geknüpft signifikant weniger Medikamente gegen intestinale Beschwerden eingenommen wurden. Was bei den Patienten zu einer deutlichen Präferenz der LPV/r-Tablette (71,2 %) gegenüber der LPV/r Kapsel (3,0 %) führte. Die Ergebnisse zu Lebensqualität zeigten zwar eine tendenzielle Besserung aber zusammen mit den Gemütszuständen ergaben sich hier keine signifikanten Unterschiede.
Nach der vorliegenden Untersuchung muss die LPV/r Tablette im Vergleich zur LPV/r-Kapsel, als die überlegene antiretrovirale Therapieoption in Betracht gezogen werden. Angesichts zahlreicher Einschränkungen durch die Infektion und die Notwendigkeit einer lebenslangen Therapie, kann dies, ein bedeutender Beitrag zur Therapietreue sein und dadurch den Erfolg einer HIV-Therapie wesentlich mitbestimmen.
Wie kommen Wissenschaft und Praxis zueinander? Unter dem Motto »Bridging the gap« stellte das Forschungsinstitut Gesellschaftlicher Zusammenhalt (FGZ) am 25. April auf einem Festival neue Formate der Wissenschaftskommunikation vor. Der UniReport sprach mit den FGZ-Referenten für Wissenstransfer Katja Maasch und Manuel Steinert.
Dass im Sachbuch allgemein und im bebilderten Sachbuch für Kinder im Speziellen mittlerweile verschiedene Formen der Informationsvermittlung existieren, bei denen einerseits die Erzählung, und andererseits die Sache selbst im Vordergrund stehen können, spiegelt sich unter anderem in Begriffen wie Sachbilderbuch, Erzählsachbuch oder Informationssachbuch (vgl. Ossowski 2000, S. 673) wider. Diese Begriffe legen offen, dass Sachbücher mittlerweile verschiedene Akzentuierungen der Kombination erzählender und informierender und daraus folgend fiktionaler und faktualer Narrationselemente aufweisen, denen die dem Sachbuch unterstellte Dichotomie dieser beiden Aspekte (vgl. Hussong 1984, S. 71) nicht gerecht wird...