Universitätspublikationen
Refine
Year of publication
- 2020 (2495) (remove)
Document Type
- Article (1439)
- Doctoral Thesis (233)
- Part of Periodical (215)
- Preprint (167)
- Contribution to a Periodical (140)
- Working Paper (115)
- Book (88)
- Review (58)
- Bachelor Thesis (11)
- Master's Thesis (11)
Language
- English (1699)
- German (764)
- Portuguese (11)
- French (6)
- Spanish (4)
- Italian (3)
- Multiple languages (3)
- slo (3)
- Turkish (2)
Keywords
- Capital Markets Union (25)
- Financial Markets (25)
- Coronavirus (24)
- ECB (24)
- COVID-19 (23)
- inflammation (18)
- SARS-CoV-2 (15)
- coronavirus (15)
- Financial Institutions (13)
- Banking Regulation (12)
- Banking Union (10)
- Comments disabled (10)
- ESMA (10)
- Macro Finance (10)
- Banking Supervision (9)
- Zeitgenössische Kunst (9)
- quality of life (9)
- Ausstellung (8)
- EBA (8)
- Household Finance (8)
- Monetary Policy (8)
- Quality of life (8)
- cancer (8)
- Digitalisierung (7)
- Inklusion (7)
- biomarker (7)
- climate change (7)
- macrophage (7)
- obesity (7)
- populism (7)
- ADHD (6)
- Adorno (6)
- Consumers (6)
- EEG (6)
- Fiscal Policy (6)
- Frankfurt am Main (6)
- Hadron-Hadron scattering (experiments) (6)
- Inflation (6)
- Low Interest Rates (6)
- Machine learning (6)
- depression (6)
- Covid-19 (5)
- Critical Theory (5)
- European Union (5)
- Financial Stability (5)
- Frankfurt School (5)
- Goethe-Universität Frankfurt (5)
- Inclusion (5)
- MRI (5)
- NMR spectroscopy (5)
- Professionalisierung (5)
- Systemic Risk (5)
- autophagy (5)
- cognition (5)
- immunotherapy (5)
- migration (5)
- pain (5)
- polytrauma (5)
- stress (5)
- stroke (5)
- ACLF (4)
- Children (4)
- Clearing (4)
- Depression (4)
- Epilepsy (4)
- Europe (4)
- Federal Reserve (4)
- Fotografie (4)
- Germany (4)
- Heavy Ion Experiments (4)
- Hochschuldidaktik (4)
- Household Crisis Barometer (4)
- Household income (4)
- Inflammation (4)
- Investments (4)
- Moderne Kunst (4)
- NMR (4)
- Phylogeny (4)
- Private Investment (4)
- Professionalization (4)
- RNA (4)
- Rare diseases (4)
- Solution NMR-spectroscopy (4)
- Stroke (4)
- Sustainable Finance (4)
- TAVI (4)
- Treatment (4)
- aortic stenosis (4)
- bipolar disorder (4)
- bladder cancer (4)
- breast cancer (4)
- crystal structure (4)
- cytokines (4)
- democracy (4)
- drug resistance (4)
- exercise (4)
- iron (4)
- miRNA (4)
- microbiome (4)
- portal hypertension (4)
- schizophrenia (4)
- tumor microenvironment (4)
- 3D printing (3)
- Abdominal aortic aneurysm (3)
- Aging (3)
- Algorithmic Discrimination (3)
- Angewandte Kunst (3)
- Aortic stenosis (3)
- Artificial Intelligence (3)
- Ausnahmezustand (3)
- Berlin (3)
- Biomarkers (3)
- Bitcoin (3)
- Cardiovascular magnetic resonance (3)
- Cirrhosis (3)
- Corona Bonds (3)
- Covid19-NMR (3)
- Cryoelectron microscopy (3)
- DNA methylation (3)
- DNA-PAINT (3)
- Datenschutz (3)
- Diagnostics (3)
- Diagnostik (3)
- EZB (3)
- Education (3)
- Embryos (3)
- Endovascular repair (3)
- Epidemiology (3)
- Freshwater (3)
- Geldpolitik (3)
- Gesundheitsökonomie (3)
- HIV (3)
- Health economics (3)
- Heart failure (3)
- Heavy-ion collision (3)
- Household finance (3)
- Human behaviour (3)
- Hypoxia (3)
- Infections (3)
- Innovation (3)
- Installation (3)
- Internet (3)
- Investor Protection (3)
- Klangkunst (3)
- Macrophages (3)
- Magnetic resonance imaging (3)
- Malerei (3)
- Mittelalter (3)
- Mortality (3)
- NASH (3)
- Non-structural protein (3)
- Offene Versorgung (3)
- Open repair (3)
- Oxidoreductases (3)
- PBPK (3)
- Pandemic (3)
- Peri-implantitis (3)
- Postural control (3)
- Preventive medicine (3)
- Quantitative Easing (3)
- Register (3)
- Registries (3)
- Registry (3)
- Religion (3)
- Strength training (3)
- Städel Museum Frankfurt (3)
- Teacher Training (3)
- Verhältnismäßigkeit (3)
- Wissenschaft (3)
- acute-on-chronic liver failure (3)
- adequate translations (3)
- apoptosis (3)
- attention (3)
- banks (3)
- child (3)
- chimeric antigen receptor (3)
- complications (3)
- concurrency (3)
- confirmatory factor analysis (3)
- crude oil (3)
- cytotoxicity (3)
- development (3)
- epilepsy (3)
- evolution (3)
- eye-tracking (3)
- financial stability (3)
- flow cytometry (3)
- fluorescence (3)
- functional programming (3)
- glioblastoma (3)
- glioma (3)
- heat stress (3)
- hippocampus (3)
- inflation (3)
- integrins (3)
- machine learning (3)
- macrophages (3)
- mesenchymal stromal cells (3)
- microRNA (3)
- monetary policy (3)
- neuroblastoma (3)
- neurodegeneration (3)
- oil price (3)
- outcome (3)
- ovarian cancer (3)
- photochemistry (3)
- physical activity (3)
- pi-calculus (3)
- precision medicine (3)
- prevalence (3)
- prevention (3)
- proliferation (3)
- prostate cancer (3)
- proteostasis (3)
- psoriasis (3)
- reactive oxygen species (3)
- sulforaphane (3)
- toxicity (3)
- transcriptome (3)
- validity (3)
- working memory (3)
- 3D rapid prototyping (2)
- ABC transporters (2)
- AML (2)
- ATP (2)
- ATR-FTIR (2)
- Abdominelles Aortenaneurysma (2)
- Adolescents (2)
- Agroecology (2)
- Algorithmic Feedback Loops (2)
- Alzheimer’s disease (2)
- Annuity (2)
- Anthropocene (2)
- Architektur (2)
- Artificial intelligence (2)
- Ascites (2)
- Ataxia telangiectasia (2)
- Atmosphere (2)
- Autism spectrum disorder (2)
- Autoritarismus (2)
- BMI (2)
- Bacterial physiology (2)
- Bacterial structural biology (2)
- Bank Lending (2)
- Bayesian Analysis (2)
- Benin (2)
- Bibliometrics (2)
- Bildung (2)
- Biochemistry (2)
- Biodiversity (2)
- Biogeography (2)
- Bladder cancer (2)
- Borrelia (2)
- Brandenburger Tor <Berlin, Motiv> (2)
- Business Cycle (2)
- Bénin (2)
- CD19 (2)
- CD44 (2)
- CNN (2)
- Cancer (2)
- Cardiology (2)
- Carl Schmitt (2)
- Cerebrospinal fluid (2)
- Chemistry (2)
- Child abuse (2)
- China (2)
- Clinical decision support systems (2)
- Cognitive archeology (2)
- Cognitive evolution (2)
- Cohort studies (2)
- Collateral Policy (2)
- Computer-assisted diagnosis (2)
- Conservation (2)
- Corporate Bonds (2)
- Corporate Debt Structure (2)
- Corporate Finance (2)
- Critical care (2)
- DDR (2)
- DNA (2)
- DSGE Estimation (2)
- DTI (2)
- Database searching (2)
- Dementia (2)
- Derivatives (2)
- Digital Humanities (2)
- Digital currency (2)
- Digitalization (2)
- Disclosure (2)
- Downy mildew (2)
- Druckgrafik (2)
- EDIS (2)
- EGFR (2)
- EU (2)
- Ecological modelling (2)
- Ecology (2)
- Educação (2)
- Eligibility premium (2)
- Emergency room (2)
- Endoscopy (2)
- Endovaskuläre Behandlung (2)
- Entrepreneurship (2)
- Erweiterter Suizid (2)
- Escola de Frankfurt (2)
- Euro (2)
- European Portuguese (2)
- Expertise (2)
- Extended suicide (2)
- Extremismus (2)
- Feldforschung (2)
- Feminismus (2)
- FinTech (2)
- Financial stability (2)
- Fintech (2)
- Framing (2)
- G-protein-coupled receptors (2)
- Gemeinschaftliche Selbsttötung (2)
- Gender (2)
- Gene expression (2)
- Gene regulation (2)
- General practice (2)
- Genetics (2)
- Geschichte / Schulbuch (2)
- Glioma (2)
- Gymnasiale Oberstufe (2)
- HIV-1 (2)
- Haloferax volcanii (2)
- Hamiltonian Monte Carlo (2)
- Health care (2)
- Healthy adults (2)
- Hepatocellular carcinoma (2)
- Histology (2)
- Horkheimer (2)
- IDH mutation (2)
- IL-10 (2)
- INS (2)
- Identification (2)
- Identität (2)
- Immunohistochemistry (2)
- Immunological methods (2)
- Immunologische Methoden (2)
- Immunology (2)
- In vitro (2)
- Inflationsmessung (2)
- Infrastructure (2)
- Integration (2)
- Interest Rates (2)
- International Economics (2)
- Interview (2)
- Invasive species (2)
- Islam (2)
- Klebsiella pneumoniae (2)
- Klinische Ergebnisse (2)
- Knochenersatzmaterial (2)
- Kohärenz (2)
- Konzeptualisierung (2)
- Kooperation (2)
- Kunstpädagogik (2)
- Language (2)
- Lebensqualität (2)
- Linguistik (2)
- Liver diseases (2)
- Liver transplantation (2)
- Long-term potentiation (2)
- MSD (2)
- Machine Learning (2)
- Medical research (2)
- Medicinal chemistry (2)
- Medien (2)
- Meta-analysis (2)
- Metaanalysis (2)
- Metabolic engineering (2)
- Methodenbericht (2)
- Mindfulness (2)
- Mobilität (2)
- Morbidity (2)
- Morphology (2)
- Motivation (2)
- Multiple sclerosis (2)
- Myocardial perfusion (2)
- NADPH oxidase (2)
- NAFLD (2)
- Neurology (2)
- Neurons (2)
- Niche construction (2)
- Notaufnahme (2)
- Object vision (2)
- Open Access (2)
- Optogenetics (2)
- Outcome (2)
- PCR (2)
- PISA (2)
- Papyri (2)
- Particle and resonance production (2)
- Patient blood management (2)
- Patients (2)
- Performance (2)
- Pneumonia (2)
- Politik (2)
- Protein drugability (2)
- Public Private Partnership (2)
- Public health (2)
- RNA structures (2)
- Radiomics (2)
- Rechtsgeschichte (2)
- Rechtswissenschaft (2)
- Reflexionskompetenz (2)
- Remuneration (2)
- Representation (2)
- Respiration (2)
- Retail investors (2)
- Searle (2)
- Seizure (2)
- Self-control (2)
- Senescence (2)
- Shear viscosity (2)
- Skulptur (2)
- Sprache (2)
- Studium (2)
- Suicide pact (2)
- Surveys (2)
- Teoria Crítica (2)
- Theodor Adorno (2)
- Trading (2)
- Transfusion (2)
- Treatment outcome (2)
- Trichoptera (2)
- Trypanosoma brucei (2)
- Validation (2)
- Vergütung (2)
- Vertragsklausel (2)
- Viral infection (2)
- Virtual Reality (2)
- Vollstreckung (2)
- Walter Benjamin (2)
- Wearable cardioverter-defibrillator (2)
- Weiterbildung (2)
- Wirecard (2)
- Women (2)
- Zeichnung (2)
- Zentralbankpolitik (2)
- Zero Lower Bound (2)
- abundance (2)
- acetogens (2)
- action-effect association (2)
- acute lymphoblastic leukemia (2)
- adaptation (2)
- adolescents (2)
- adult (2)
- aging (2)
- algorithms (2)
- alveolar ridge augmentation (2)
- animal experiment (2)
- antiepileptic drugs (2)
- atonality (2)
- auditory cortex (2)
- augmentation (2)
- banking (2)
- bibliometrics (2)
- biodiversity (2)
- biomarkers (2)
- biopolitics (2)
- body mass index (2)
- bulk viscosity (2)
- cardiac surgery (2)
- causality (2)
- cell-free expression (2)
- cerebral hemorrhage (2)
- cerebral venous thrombosis (2)
- chemoresistance (2)
- children (2)
- chloroplasts (2)
- cirrhosis (2)
- cleaning (2)
- climate (2)
- clinical studies (2)
- coagulopathy (2)
- combination therapy (2)
- comparative analysis (2)
- complement (2)
- comprehension (2)
- connectedness to nature (2)
- connection to nature (2)
- connective tissue (2)
- continuous performance test (2)
- corporate finance (2)
- curcumin (2)
- cystic fibrosis (2)
- cytomegalovirus (2)
- dark energy (2)
- data science (2)
- decision making (2)
- decompensated liver cirrhosis (2)
- delirium (2)
- democratic backsliding (2)
- density functional theory (2)
- dental education (2)
- dental implants (2)
- dental profession (2)
- dentoalveolar surgery (2)
- diabetes mellitus (2)
- direct-acting antivirals (2)
- distress (2)
- dodecaphony (2)
- drug discovery (2)
- education (2)
- elderly (2)
- electroencephalography (2)
- environmental tobacco smoke (2)
- executive function (2)
- expectations (2)
- exploratory structural equation modeling (2)
- fMRI (2)
- fascia (2)
- fibroblasts (2)
- fibrosis (2)
- financial markets (2)
- fiscal policy (2)
- fluorine (2)
- frontal cortex (2)
- gait analysis (2)
- gasoline price (2)
- gender (2)
- gene expression (2)
- global justice (2)
- grit (2)
- growth (2)
- hepatic encephalopathy (2)
- hepatocellular carcinoma (2)
- higher education (2)
- histology (2)
- hyperactivity (2)
- hypoxia (2)
- immunity (2)
- immunosuppression (2)
- impulsivity (2)
- inclusion (2)
- inclusive education (2)
- inequality (2)
- infection (2)
- innate immunity (2)
- institutions (2)
- integration (2)
- integrin (2)
- invariance testing (2)
- joint contact forces (2)
- journalism (2)
- kidney (2)
- law (2)
- liver (2)
- liver cirrhosis (2)
- local-field potentials (2)
- loss (2)
- lung cancer (2)
- lung function (2)
- lymphocytes (2)
- mTOR (2)
- mass spectrometry (2)
- memory (2)
- mental health (2)
- metformin (2)
- mice (2)
- minerals (2)
- mitochondria (2)
- molecular dynamics (2)
- molecular machines (2)
- motivation (2)
- multilingualism (2)
- multiple sclerosis (2)
- musculoskeletal disorders (2)
- musculoskeletal modeling (2)
- natural killer cells (2)
- neural oscillations (2)
- neurocognition (2)
- oncology (2)
- oral and maxillofacial surgery (2)
- pancreatic cancer (2)
- patient blood management (2)
- periodontitis (2)
- polygenic risk score (2)
- positive psychological coaching (2)
- positive psychological interventions (2)
- post-translational modifications (2)
- prediction (2)
- privacy (2)
- prognosis (2)
- protein degradation (2)
- protein synthesis (2)
- proteome (2)
- proteomics (2)
- psychometric properties (2)
- public debt (2)
- public health (2)
- questionnaire (2)
- recapitalization (2)
- reductases (2)
- renal cell carcinoma (2)
- resistance training (2)
- rhodesain (2)
- risk factors (2)
- risk prediction (2)
- risk-taking (2)
- screening (2)
- security (2)
- sepsis (2)
- severe acute respiratory syndrome coronavirus 2 (2)
- short-sales (2)
- simulation training (2)
- social isolation (2)
- solid-state NMR (2)
- solidarity (2)
- sphingosine 1-phosphate (2)
- sphingosine 1-phosphate receptor (2)
- sphingosine kinase (2)
- sphingosine-1-phosphate (2)
- spinal dural leaks (2)
- stock market (2)
- structural biology (2)
- superficial siderosis (2)
- surgery (2)
- survival (2)
- survivin (2)
- thrombosis (2)
- thymus (2)
- trace elements (2)
- transcriptomics (2)
- transnationalism (2)
- transplantation (2)
- tumor growth (2)
- tumor progression (2)
- ubiquitin (2)
- visual attention (2)
- von Willebrand factor (2)
- welfare state (2)
- öffentlich-medialer Diskurs (2)
- (cardiac) surgery (1)
- 1,4-naphthoquinone (1)
- 11N45 (1)
- 14-3-3 gene family (1)
- 14N10 (secondary) (1)
- 16 segment AHA model (1)
- 16. Jahrhundert (1)
- 16S rRNA sequencing (1)
- 1968 (1)
- 1969 (1)
- 19F (1)
- 19F MR spectroscopy (1)
- 1H MR spectroscopy (1)
- 2'-deoxyguanosine riboswitch (1)
- 2-aminobenzimidazole (1)
- 2-hydroxyglutarate (1)
- 2019-nCoV (1)
- 3' UTR (1)
- 3,4-DCA; biotransformation (1)
- 3-alkylphenols (1)
- 3-hydroxyanthranilic acid (1)
- 30F30 (1)
- 32G15 (primary) (1)
- 3D printed cell-free scaffold (1)
- 3D reconstruction and image processing (1)
- 3D-Druck (1)
- 4-fluoroamphetamine (1)
- 401(k) plan (1)
- 5-lipoxygenase (1)
- 5-lipoxygenase; (1)
- 6-methylsalicylic acid synthase (1)
- 9-HODE (1)
- A-FFIP (1)
- A. thaliana (1)
- A2BP1 (1)
- AAA+ disaggregase (1)
- ABC proteins, ribosome recycling (1)
- ABCB1 (1)
- ABCC1 (1)
- ACE-Bestimmung (1)
- AChE (1)
- ADAMTS-13 (1)
- ADAMTS13 (1)
- ADGRE1 (1)
- ADHD differential diagnosis (1)
- ADHS (1)
- AKI (1)
- ALICE (1)
- ALL (1)
- AM-PM noise conversion (1)
- AMH (1)
- AML – acute myeloid leukemia (1)
- APCO (1)
- API (1)
- ARDS (1)
- ART (1)
- ASD-specific (1)
- ASPECTS (1)
- ATP binding (1)
- ATPases (1)
- Abductor pollicis longus (1)
- Ablation (1)
- Abrasion (1)
- Absenteeism (1)
- Absorption modeling (1)
- Abundance (1)
- Abusive head trauma (AHT) (1)
- Acacia (1)
- Accelerators & Beams (1)
- Accelerators & storage rings (1)
- Access (1)
- Accumulated degree days (1)
- Acellular dermis (1)
- Acoustic signals (1)
- Acoustics (1)
- Action potentials (1)
- Acute HIV infection (1)
- Acute appendicitis (1)
- Acute elbow dislocation (1)
- Acute hospital (1)
- Acute lymphoblastic leukemia (1)
- Acute lymphocytic leukaemia (1)
- Acute-on-chronic subdural hematoma (1)
- Addison’s disease (1)
- Adenosine (1)
- Adherence (1)
- Adipose tissue (1)
- Administrative claims data (1)
- Adorno et Sartre (1)
- Adorno Theodor (1)
- Adorno and Sartre (1)
- Adorno e Sartre (1)
- Advanced breast cancer (1)
- Adverse drug reaction (1)
- Advertising (1)
- Aesthetics (1)
- Affektregime (1)
- African Sleeping Sickness (1)
- Afrikanische Schlafkrankheit (1)
- Age (1)
- Age determination (1)
- Age determination by skeleton (1)
- Age groups (1)
- Aggregate outcomes (1)
- Aging society (1)
- Akazie (1)
- Albania (1)
- Albanija (1)
- Albert Londres (1)
- Albumin ratio (1)
- Algorithms (1)
- Alkaloid (1)
- Allergic rhinitis (1)
- Allgemeinmedizin (1)
- Allocative Effciency (1)
- Allogeneic (1)
- Alloy (1)
- Alpha oscillations (1)
- Alternative zum Westen (1)
- Altruism (1)
- Alzheimer's disease (1)
- Amino acid analysis (1)
- Amisulpride (1)
- Amitriptyline (1)
- Amplification (1)
- Anaerobic bacteria (1)
- Anandamide (1)
- Anatomy (1)
- Anderson–Fabry (1)
- Andesites (1)
- Andropogon virginicus (1)
- André Gide (1)
- Aneignung (1)
- Anforderungsbearbeitung (1)
- Angiogenesis (1)
- Angiotensin Converting Enzyme (1)
- Angiotensin-converting enzyme (1)
- Animal model (1)
- Animal personality (1)
- Anionic boranes (1)
- Annotation (1)
- Annuities (1)
- Anselm Kiefer (1)
- Anterior cruciate ligament reconstruction (1)
- Anti-CMV IgG (1)
- Anti-inflammatory (1)
- Anti-rheumatic agents (1)
- Antibiotic resistance (1)
- Anticholinergic (1)
- Anticoagulant (1)
- Anticoagulant therapy (1)
- Anticoagulants (1)
- Anticoagulation (1)
- Antidepressiva (1)
- Antigen carrier (1)
- Antigens/Peptides/Epitopes (1)
- Antihormone therapy (1)
- Antinomien (1)
- Antiviral immune response (1)
- Aortic input function (1)
- Apache Spark (1)
- Apoptosis (1)
- App (1)
- App ecosystem (1)
- Appendectomy (1)
- Applied microbiology (1)
- Appraisal rights (1)
- Appropriation (1)
- Aquilegia (1)
- Arbeit und Subjektivität (1)
- Arbeitsgedächtnis (1)
- Arbeitsorientierungen (1)
- Arbeitssoziologie (1)
- Archaea (1)
- Archaeogeophysics (1)
- Archaeology (1)
- Arctic Ocean (1)
- Argentinean Historiography (1)
- Argumentative theory of reasoning (1)
- Arithmetic-geometric exponentials (1)
- Arousal (1)
- Arrhythmia syndromes (1)
- Art-education (1)
- Artenschutz (1)
- Arthroplasty (1)
- Article 7 (1)
- Artificial Intelligence, (1)
- Asien (1)
- Asset Price Bubbles (1)
- Asset allocation (1)
- Assistive technology (1)
- Ataxia score (1)
- Atg8 (1)
- Athletes (1)
- Atm (1)
- Atmospheric chemistry (1)
- Atmospheric science (1)
- Atomic & molecular beams (1)
- Atomic and Molecular Physics (1)
- Atomic, Molecular & Optical (1)
- Atrial fibrillation (1)
- Attention deficit (1)
- Attitude face au travail (1)
- Audio-podcast (1)
- Auditing (1)
- Auditory cortex (1)
- Auditory midbrain (1)
- Auditory system (1)
- Aufmerksamkeit (1)
- Aufmerksamkeitsleistung (1)
- Ausbildung (1)
- Ausgangssperre (1)
- Austen Jane (1)
- Austin (1)
- Autoimmune vasculopathy (1)
- Autologous biomaterial (1)
- Autophagy (1)
- Autopsy (1)
- Awareness campaign (1)
- Axiography (1)
- B and Sr isotopes (1)
- B cells (1)
- B-cell lymphoma (1)
- B-cell receptor (1)
- BAG3 (1)
- BCL6 (1)
- BCS phase (1)
- BCX7353 (1)
- BDNF (1)
- BET inhibitor (1)
- BEZ235 (1)
- BFIS (1)
- BG-index (1)
- BIRC5 (1)
- BK channel (1)
- BMC (1)
- BMP signaling (1)
- BRD4 (1)
- BRICS (1)
- BRICS-Staaten (1)
- Bacterial abundance (1)
- Bacterial genetics (1)
- Bacteriology (1)
- Bagatelltrauma (1)
- Bakterien (1)
- Bakterientest (1)
- Balloon-expandable TAVI (1)
- Bank regulation (1)
- Bankenunion (1)
- Banking Crisis (1)
- Banking Supervision, (1)
- Banks (1)
- Bantu (1)
- Base metal sulphides (1)
- Batch Learning (1)
- Bathyergidae (1)
- Bats (1)
- Bauchaortenaneurysma (1)
- Bayern (1)
- Bayesian Estimation (1)
- Bayesian Statistics (1)
- Bayesian inference (1)
- Beam loss (1)
- Bee venom allergy (1)
- Begriffsbestimmung (1)
- Behandlungskapazität (1)
- Behandlungsvollzug (1)
- Behavior (1)
- Behavior change (1)
- Behavioral disorders (1)
- Behavioral reaction norms (1)
- Behavioral specialization (1)
- Behavioral syndromes (1)
- Behavioral type (1)
- Behavioural ecology (1)
- Behavioural methods (1)
- Behinderungserfahrung (1)
- Beitragsgarantien (1)
- Belastung (1)
- Bell theorem (1)
- Benefits (1)
- Benign enlargement of the subarachnoid spaces (BESS) (1)
- Benign pulmonary diseases (1)
- Benigne Lungenerkrankungen (1)
- Berkovich spaces (1)
- Berufliche Bildung (1)
- Bestimmungsmethoden (1)
- Bestrahlung (1)
- Betriebliche Gesundheitsförderung (1)
- Bewegungsanalyse mit Inertialsensoren (1)
- Bewegungsstörung (1)
- Biel (1)
- Bildgebung (1)
- Bildungsfachkräfte (1)
- Bilingualism (1)
- Bilingualität (1)
- Binding Kinetics (1)
- Binding kinetic (1)
- BioID (1)
- Bioacoustics (1)
- Bioavailability prediction (1)
- Biocatalysis (1)
- Biodiversity Data (1)
- Biodiversity loss (1)
- Bioenergetics (1)
- Bioequivalence (1)
- Biologging (1)
- Biomarker (1)
- Biomineralization (1)
- Biomonitoring (1)
- Biophysik (1)
- Biopolitik (1)
- Biopsy (1)
- Biosecurity (1)
- Biota (1)
- Biotechnology (1)
- Biowaiver (1)
- Black Lipid Membrane (1)
- Blastocysts (1)
- Bleeding (1)
- Blindheit und Sehbehinderung (1)
- Blocked occlusion (1)
- Blood flow (1)
- Board of Directors (1)
- Body limbs (1)
- Body measurements (1)
- Body modification (1)
- Body temperature (1)
- Boidae (1)
- Bolivia (1)
- Bone defect (1)
- Bone regeneration (1)
- Bone remodelling (1)
- Bone substitute (1)
- Bone tissue engineering (1)
- Botanical Collections (1)
- Brain asymmetry (1)
- Brain injuries (1)
- Brain size I (1)
- Brain structure (1)
- Brain tumor surgery (1)
- Brain tumors (1)
- Brain-stimulus synchrony (1)
- Brassicales (1)
- Breast cancer survivers (1)
- Breathing (1)
- Brexit (1)
- Brics (1)
- Brittany (1)
- Bromeliads (1)
- Bronzestatuetten (1)
- Bruno Latour (1)
- Brustkrebs (1)
- Buchner, Franz Xaver (1)
- Built environment (1)
- Burden (1)
- Burden of illness (1)
- Business Cycles (1)
- Business lending (1)
- Business psychology (1)
- Bürgerbeteiligung (1)
- Büroangestellte (1)
- C-mannosylation (1)
- C-value (1)
- C1 inhibitor (1)
- C2 domain (1)
- CAD/CAM (1)
- CAKUT (1)
- CAR (1)
- CCL2 (1)
- CD107-Assay (1)
- CD3 (1)
- CD34 + cells (1)
- CD4 binding site (1)
- CD41 (1)
- CD49d (1)
- CD62P (1)
- CD8+ T cell (1)
- CDI (1)
- CDK9 (1)
- CEBPD (1)
- CEP-1 (1)
- CIE-11 (1)
- CIRS (1)
- CLP (1)
- CMU (1)
- CMVepidemiology (1)
- CO2 (1)
- CO2 fertilization (1)
- CO2-Steuer (1)
- COINS (1)
- COMP (1)
- COVID 19 pandemic (1)
- COVID-19 news (1)
- COVID19-NMR (1)
- CPT1A (1)
- CRE-dependent transcription (1)
- CRISPR/Cas9 (1)
- CSR (1)
- CUE domain (1)
- CUELA system (1)
- CXCL10 (1)
- CXCR3 (1)
- Calathea (1)
- Calculation (1)
- Callous-unemotional traits (1)
- Calpain (1)
- Camera trapping (1)
- Cancer check up (1)
- Cancer treatment (1)
- Candida spp (1)
- Cannabidiol (1)
- Capital theory (1)
- Capnography (1)
- Carbanions (1)
- Carbonate (1)
- Carbonated apatite (1)
- Cardiac acoustic biomarkers (1)
- Cardiac arrest (1)
- Cardiac masses (1)
- CardioMEMS™ HF system (1)
- Careers (1)
- Carl Schmit (1)
- Carl von Clausewitz (1)
- Caspase-8 (1)
- Caudate nucleus (1)
- Cell death and immune response (1)
- Cell differentiation (1)
- Cell staining (1)
- Cell-based therapies (1)
- Cellular microbiology (1)
- Cellular neuroscience (1)
- Central nervous system (1)
- Cerebellum (1)
- Cerebral cortex (1)
- Cerebral hypoperfusion (1)
- Cerebrovascular disorders (1)
- Ceteris paribus laws (1)
- Cezanne (1)
- Chad (1)
- Challenge and hindrance stressors (1)
- Charge-transfer collisions (1)
- Charmed mesons (1)
- Checkpoint inhibitor (1)
- Chemical dispersant (1)
- Chemical tools (1)
- Chemicals of emerging concern (1)
- Chemoradiation (1)
- Chemotherapie (1)
- Chemotherapy (1)
- Child (1)
- Child health (1)
- Children and adolescents (1)
- Chimiothérapie (1)
- Chiquitano Dry Forest (1)
- Chiral symmetry (1)
- Chiral symmetry restoration (1)
- Chirurgie (1)
- Choice experiments (1)
- Chromatin accessibility (1)
- Chromatin conformation (1)
- Chronic conditions (1)
- Chronic depression (1)
- Chronic inflammation (1)
- Chronology of disease (1)
- Chrysops (1)
- Circular accelerators (1)
- Citizenship (1)
- Citizenship Law (1)
- Claims on land (1)
- Classification (1)
- Clavien–Dindo classification (1)
- Climate (1)
- Climate change (1)
- Climate inequity (1)
- Clinical genetics (1)
- Clinical relevant dissolution specification (1)
- Clinical trial (1)
- Clinical trials (1)
- Clostridium (1)
- Clumped isotopes (1)
- Clustering coefficients (1)
- CoVaR (1)
- Coagulation (1)
- Coagulopathy management (1)
- Cognition (1)
- Cognitive behavioral therapy (1)
- Cognitive control (1)
- Cognitive impairment (1)
- Cognitive neurology (1)
- Cognitive neuroscience (1)
- Cognitive science (1)
- Cold hardiness (1)
- Cold tolerance (1)
- Collagen-based biomaterial (1)
- Collective Action (1)
- Collective Expulsion (1)
- Collectivity (1)
- Colonic neoplasms (1)
- Combo® DTS (1)
- Common Agricultural Policy (1)
- Common humanity (1)
- Communication (1)
- Comovements (1)
- Compact stars (1)
- Companion-type robots (1)
- Company founders (1)
- Comparators (1)
- Compassionate writing exercises (1)
- Compatibility (1)
- Complete survey (1)
- Complications (1)
- Compression stocking (1)
- Computational Biology (1)
- Computational biophysics (1)
- Computational modelling (1)
- Computed axial tomography (1)
- Computer hardware (1)
- Computer science (1)
- Computer software (1)
- Computer-aided drug design (1)
- Computers (1)
- Comunicación (1)
- Concept paper (1)
- Conduct disorder (1)
- Conduct problems (1)
- Confinement (1)
- Conflict (1)
- Conflict-driven memory enhancements (1)
- Conflicts (1)
- Congenital CMVinfection (1)
- Congenital anomalies (1)
- Congenital diaphragmatic hernia (1)
- Connectivity (1)
- Connectomics (1)
- Conservative treatment (1)
- Constitution (1)
- Consumer credit (1)
- Consumer demand (1)
- Consumption (1)
- Contemporary History (1)
- Continuous Process Verification (1)
- Control (1)
- Cooperation (1)
- Copy number (1)
- Corona Constitutional (1)
- Corona-Krise (1)
- Corona-Steuerhilfegesetz (1)
- Coronary artery disease (1)
- Corporate Social Responsibility (1)
- Corporate governance (1)
- Corporate law (1)
- Correlation (1)
- Cortical degeneration (1)
- Cortical thickness (1)
- Cortisol im Speichel (1)
- Cortisol secretion (1)
- Costa Rica (1)
- Covid-19-Crisis (1)
- Cp (1)
- Cpk (1)
- Craniomaxillofacial injuries (1)
- Cratonic lithosphere (1)
- Creditor Rights (1)
- Critical Online Reasoning Assessment (1)
- Critical size (1)
- Critique of Value (1)
- Croatia (1)
- Crohn's disease (1)
- Crohn’s disease (1)
- Crustacea (1)
- Cryptocurrencies (1)
- Crítica do Valor (1)
- CspA (1)
- CspZ (1)
- Cultura (1)
- Cultural Studies (1)
- Cultural evolution (1)
- Culture (1)
- Curriculum (1)
- Cybersecurity (1)
- Cybersicherhheit (1)
- Cyclization (1)
- Cyp46a1 (1)
- CysLTR1 (1)
- Cysteine‐Rich Domain (CRD) (1)
- Cystic fibrosis (1)
- Cytokines (1)
- Cytomegalovirus (CMV) (1)
- DA (1)
- DAMPs (1)
- DBS (1)
- DDC (1)
- DEER or PELDOR (1)
- DFNB9 (1)
- DILI (1)
- DIPSHIFT (1)
- DNA G-quadruplex (1)
- DNA barcoding (1)
- DNA damage (1)
- DNA damage response (1)
- DNA pulldown (1)
- DNA sequence analysis (1)
- DNA-LNA mixmers (1)
- DNA-protein-interactions (1)
- DNase1-seq (1)
- DRG (1)
- DSM-5 (1)
- DSM5 (1)
- DST (1)
- DYRK1A (1)
- Darunavir (1)
- Data processing (1)
- Data protection (1)
- Data quality (1)
- Data science (1)
- Datenverarbeitung (1)
- Datong coalfield (1)
- Decision making (1)
- Decontamination (1)
- Deductive logic (1)
- Deep learning (1)
- Deep vein thrombosis (1)
- Default (1)
- Defibrillation (1)
- Degrowth (1)
- Dehnen (1)
- Delegation (1)
- Demand estimation (1)
- Demenz (1)
- Democracia Liberal (1)
- Democracy (1)
- Democratic Republic of the Congo (1)
- Demokratie (1)
- Density equalizing mapping (1)
- Density-equalizing mapping (1)
- Dental air (1)
- Dental casts (1)
- Dental implant (1)
- Dental implants (1)
- Dental practice (1)
- Dental students (1)
- Deposit Insurance (1)
- Dermal fat (1)
- Design (1)
- Design functions (1)
- Determination method (1)
- Deutsch als Zweitsprache (1)
- Developmental biology (1)
- Developmental disorders (1)
- Dewey Decimal Classification (1)
- DgkA (1)
- DiSSCo (1)
- Diabetes mellitus (1)
- Diagnosis (1)
- Diagnosis related groups (1)
- Diagnostic algorithm (1)
- Diagnostic error (1)
- Diagnostic markers (1)
- Diatomophthora (1)
- Dicellomyces (1)
- Dicer (1)
- Dickeya (1)
- Differential diagnosis (1)
- Diffraction (1)
- Diffuse large B-cell lymphoma (1)
- Digital Specimen (1)
- Digital media (1)
- Digital technologies (1)
- Digitale Technologien (1)
- Digitalität (1)
- Digitization (1)
- Dimerization domain (1)
- Direct estimation (1)
- Disabilities (1)
- Disaster victim identification (1)
- Disc herniation (1)
- Discount Rates (1)
- Discourse (1)
- Diseases (1)
- Disengagement research (1)
- Disintegration (1)
- Diskriminierung (1)
- Diskurs (1)
- Diskurstheorie (1)
- Dispersal capacity (1)
- Display advertising (1)
- Dissertation (1)
- Dissolution (1)
- Distress screening (1)
- Distributed Computing (1)
- Distributed System of Scientific Collections (1)
- Distribution limits (1)
- Dividends (1)
- Dokumentarische Methode (1)
- Dopamine (1)
- Doppler radar (1)
- Doris Salcedo (1)
- Double suicide (1)
- Double-blind placebo-controlled trial (1)
- Douleur (1)
- Drag-along rights (1)
- Dravet syndrome (1)
- Drogenhandel (1)
- Drosophila melanogaster (1)
- Drug discovery (1)
- Drug permeability (1)
- Drug screening (1)
- Drug susceptibility testing (1)
- Dual cone (1)
- Duelo (1)
- Dunkelziffer (1)
- Dural onlays (1)
- Duration of Civil Proceedings (1)
- Dynamic covalent chemistry (1)
- Dynamics (1)
- Dyslexia (1)
- Dysphagia (1)
- Désir d’enfant (1)
- E-NTPDase (1)
- E3 ligase (1)
- EBM (1)
- EEG reference choices (1)
- EGFR pathway (1)
- EGFRvIII mutation (1)
- EGR1-dependent transcription (1)
- ELISA (1)
- EMR1 (1)
- EMT (1)
- EPR spectroscopy (1)
- EQIP (1)
- ERAD (1)
- ERBB2 (HER2/neu) (1)
- ERK3 (1)
- EROD (1)
- ES (1)
- ESG (1)
- ESG Rating Agencies (1)
- ESMO-MCBS (1)
- EU Parliament (1)
- EU Recovery Funds (1)
- Early Permian (1)
- Early intervention (1)
- Eating disorders (1)
- Ebola virus (1)
- Echo-Räume (1)
- Echolocation (1)
- Echovirus-30 (1)
- Econometrics (1)
- Economic Governance (1)
- Economic and Monetary Union (1)
- Economics (1)
- Ecosystem Services (1)
- Ecosystem services (1)
- Ecosystems (1)
- Ecto-5'-nucleotidase (1)
- Ectrogella (1)
- Edoxaban (1)
- Educational texttechnology (1)
- Educação musical (1)
- Effective Field Theories (1)
- Effective hadron theories (1)
- Effective lower bound (1)
- Efflux system (1)
- Eilrechtsschutz (1)
- Einkaufszentren (1)
- Einlagensicherung (1)
- Einstellungen (1)
- Einwilligungsfähigkeit (1)
- Eisenmangel (1)
- Ejection fraction (1)
- Elastic scattering (1)
- Elderly (1)
- Electrical stimulation (1)
- Electron microscopy (1)
- Electronic transitions (1)
- Electroweak interaction (1)
- Eleştirel Kuram (1)
- Elfenbein (1)
- Email (1)
- Embodied performances (1)
- Embryo toxicity (1)
- Emergency treatment (1)
- Emotional memory (1)
- Emotionale Kompetenz (1)
- Emotions (1)
- Employee well-being (1)
- Employé.e.s hautement qualifié.e.s (1)
- Enantioselektive Katalyse (1)
- End-of-life decisions (1)
- Endemis-mus (1)
- Endocrinology (1)
- Endometrial carcinoma (1)
- Endometriome (1)
- Endométriomes (1)
- Endothelial cells (1)
- Endothelial protein C receptor (1)
- Endovaskuläre Versorgung (1)
- Endpoints (1)
- Energiewettbewerb (1)
- Energy conservation (1)
- Energy metabolism (1)
- Energy reserves (1)
- Enforcement (1)
- Englischunterricht (1)
- Enseñanza universitaria (1)
- Enterobacteriaceae (1)
- Entomology (1)
- Entry and exit (1)
- Entscheidungsassistenz (1)
- Entstellung (1)
- Envelope (1)
- Eocene; pit organs (1)
- Ephemeroptera (1)
- Epidemiologic model (1)
- Epidemiological data (1)
- Epidemiologisches Modell (1)
- Epidural abscess (1)
- Epigenetics (1)
- Epilepsie (1)
- Episodic memory (1)
- Epistemologie (1)
- Epstein-Barr virus (1)
- Equation of state (1)
- Equity fund (1)
- Erasmianismus (1)
- Erasmus von Rotterdam (1)
- Erasmus, Desiderius (1)
- Erdnussallergie (1)
- Ergonomic analysis (1)
- Ergonomie am Arbeitsplatz (1)
- Ergonomische Analyse (1)
- Erregerspektrum der Tonsillitis (1)
- Erwachsene (1)
- Erwerb der Satzstruktur (1)
- Estética (1)
- Ethik (1)
- Ethiopia (1)
- Ethnizität (1)
- European Alps (1)
- European Commission (1)
- European Green Deal (1)
- European electricity grid (1)
- Europoeic media (1)
- Eurozone (1)
- Evaluation (1)
- Evidence based medicine (1)
- Evidence-based dentistry (1)
- Evidence-based medicine (1)
- Evidenzbasierte Medizin (1)
- Evolution (1)
- Ewing sarcoma (1)
- Excess sensitivity (1)
- Excitatory balance (1)
- Exercise challenge (1)
- Exercise therapy (1)
- Exercise-induced asthma (1)
- Exhaled nitric oxide (1)
- Expectation formation (1)
- Expected credit losses (1)
- Experience (1)
- Experimental Economics (1)
- Experts (1)
- External-/self-assessment (1)
- Extremhabitat (1)
- Eye movements (1)
- Eye tracking (1)
- F4/80 (1)
- F508del homozygous (1)
- FBDD (1)
- FBK-R23 (1)
- FBS (1)
- FDM (1)
- FET (1)
- FEV1 (1)
- FFF (1)
- FHIR (1)
- FIH1 (1)
- FLT3-ITD (1)
- FM radar (1)
- FTAM and OX063 (1)
- FTMT (1)
- Fabclavine (1)
- Fachlichkeit (1)
- Factor H (1)
- Fahrradstraße (1)
- Fahrradstraßen (1)
- Failed states (1)
- Fair value (1)
- Fair value accounting (1)
- Far from equilibrium (1)
- Fasting (1)
- Fat layer (1)
- Fecundity (1)
- Feedback (1)
- Feedback loop (1)
- Felidae (1)
- Female subjects (1)
- Ferritinophagy (1)
- Ferroptose (1)
- Ferroptosis (1)
- Fertilität (1)
- Fertilité (1)
- Fibromyalgia (1)
- Fictional expectations (1)
- Fiktive Erwartungen (1)
- Film (1)
- Film communication (1)
- Film culture (1)
- Film heritage (1)
- Film theory (1)
- Filmtheorie (1)
- Finance (1)
- Finance and Employment (1)
- Financial Crises (1)
- Financial Integration (1)
- Financial Reporting (1)
- Financial crisis (1)
- Financial literacy (1)
- Financing Constraints (1)
- Financing Costs (1)
- Finevo (1)
- Fingolimod (1)
- Finite-temperature QFT (1)
- Fire Sales (1)
- Firm value (1)
- First-line regimen (1)
- Fiscal Policies (1)
- Fiscal Solidarity (1)
- Fiscal Stimulus Program (1)
- Five-Konzept (1)
- Fixed-Income (1)
- Flavin homeostasis (1)
- Fluctuations of conserved charges (1)
- Fluid therapy (1)
- Fokusgruppe (1)
- Food effect (1)
- Forced expiratory volume in 1 s (1)
- Foreign language (1)
- Forensic Architecture (1)
- Forensic entomology (1)
- Forensic examination (1)
- Formation and Education (1)
- Formação e Educação (1)
- Forschungsmethoden (1)
- Fortbildung (1)
- Fourier analysis (1)
- Fractional Laplacian (1)
- Fracture (1)
- Fracture type (1)
- Fragebogenentwicklung (1)
- Fragebogenerstellung (1)
- Fragile Staaten (1)
- Fragile states (1)
- Fragment (1)
- Frankfurt (1)
- Frankfurt Okulu (1)
- Frankfurt School of Philosophy (1)
- Frankfurt school (1)
- Frankfurter Schule (1)
- Frauenrechte im Islam (1)
- Freedom of research (1)
- Freiheit (1)
- French (1)
- Fresh frozen plasma (1)
- Freshwater ecology (1)
- Frictions (1)
- Friedrich I., Heiliges Römisches Reich, Kaiser (1)
- Full waveform (1)
- Functional characterization (1)
- Functional clustering (1)
- Functional mitral regurgitation (1)
- G protein-coupled receptors (1)
- G quadruplex helicase RHAU (1)
- G-CSF (1)
- G-Quadruplex (1)
- G-quadruplexes (1)
- G2A receptor (1)
- GABA (1)
- GABARAP (1)
- GABAergic (1)
- GC content (1)
- GCM (1)
- GCN (1)
- GDPR (1)
- GFAP (1)
- GHQ-28 (1)
- GIRD (1)
- GIS (1)
- GLA deficiency (1)
- GMM Estimation (1)
- GPCR (1)
- GWAS (1)
- Gait analysis (1)
- Gale-dual pairs (1)
- Game Theory (1)
- Gas gangrene (1)
- Gastrocnemius muscles (1)
- Gastroschisis (1)
- Gaussian Processes (1)
- Geistiges Eigentum (1)
- Geld (1)
- Gender-Normen (1)
- Gene expression prediction (1)
- Generation Cryo (1)
- Genetic heart disease (1)
- Genetic syndromes (1)
- Genetic variation (1)
- Genre (1)
- Geoffrey Burnstock (1)
- Geographical disparities (1)
- Georg Wilhelm Friedrich Hegel (1)
- George Bernard Shaw (1)
- German Romanticism (1)
- German science council (1)
- Germany Neolithic (1)
- Gerontologie (1)
- Geschichte (1)
- Geschichte 1500-1600 (1)
- Geschichtsschreibung (1)
- Geschlecht (1)
- Gesellschaft (1)
- Gesundheit (1)
- Gesundheitsamt (1)
- Gesundheitsberichterstattung (1)
- Gesundheitsbildung (1)
- Gesundheitserziehung (1)
- Gesundheitsförderung (1)
- Gesundheitswissenschaften (1)
- Gewalt gegen Frauen (1)
- Gewerbesteuer (1)
- Gig economy (1)
- Glauber and Giessen Boltzmann–Uehling–Uhlenbeck (GiBUU) models (1)
- Glioblastom (1)
- Global Citizenship Education (1)
- Global positioning system (1)
- Global warming (1)
- Globular textures (1)
- Goethe Johann Wolfgang von (1)
- Gouvernementalität (1)
- Governmentality (1)
- Graminicolous downy mildews (1)
- Graph generation (1)
- Graph theory (1)
- Gravitational waves (1)
- Gray matter volume (1)
- Great Recession (1)
- Green Tobacco Sickness (GTS) (1)
- Greenhouse effect (1)
- Grobstrukturanalyse (1)
- Groomed jet radius (1)
- Growth (1)
- Großprojekte (1)
- Grundrechte (1)
- Grundschullehrkräfte (1)
- Guided bone regeneration (GBR) (1)
- Guided tissue regeneration (GTR) (1)
- Guidelines (1)
- Gut microbiome (1)
- Gymnasium (1)
- Gαq/11 (1)
- H/ACA-RNP (1)
- HADS (1)
- HAE (1)
- HBV filaments (1)
- HBV genotypes (1)
- HBV surface protein (1)
- HCC (1)
- HCC recurrence (1)
- HCV (1)
- HDAC (1)
- HDAC and BET inhibitor (1)
- HDAC inhibitor (1)
- HDAC4 (1)
- HEUS (1)
- HEV (1)
- HFrEF (1)
- HHUSD (1)
- HHole (for Mannheim) (1)
- HIBCPP cells (1)
- HIFT (1)
- HILI (1)
- HIV-1 escape restriction (1)
- HIV-positive Literatur (1)
- HIV-positive literature (1)
- HIV/AIDS (1)
- HLA DQ haplotypes (1)
- HLA class I (1)
- HNSCC (1)
- HOSO (1)
- HRM (1)
- Hadron Spectroscopy (1)
- Haematocrit (1)
- Haematopota (1)
- Haemodynamic monitoring (1)
- Halogenation (1)
- Handlungswissen von Lehrpersonen (1)
- Handwriting (1)
- Hassrede (1)
- Hausarztmangel (1)
- Haushalte mit Kindern (1)
- Haushaltskrisenbarometer (1)
- Hawkes processes (1)
- HbA1c (1)
- HeLa cells (1)
- Health care sector (1)
- Health education and awareness (1)
- Health literacy (1)
- Health policy (1)
- Health services (1)
- Healthcare costs (1)
- Healthcare resource utilization (1)
- Health‐related quality of life (1)
- Heat dissipation (1)
- Heat shock protein 27 (1)
- Heavy Ion Phenomenology (1)
- Heavy baryons (1)
- Heavy ion collisions (1)
- Heavy-ion collisions (1)
- Heavy-ion physics (1)
- Heavy-quark symmetry (1)
- Helicoptergeld (1)
- Hematologic malignancies (1)
- Hematoxylin staining (1)
- Hemispheric specialization (1)
- Hemodynamics (1)
- Hepatic encephalopathy (1)
- Hepatitis C virus (1)
- Herbaria (1)
- Herdenimmunität (1)
- Heregulin (1)
- Hermann Schmitz (1)
- Hessen (1)
- Heterocycles (1)
- Heterogeneity (1)
- Heterogenität (1)
- HiC (1)
- HiChIP (1)
- High oblique sagittal osteotomy (1)
- High-Level-Forum (1)
- High-Speed photography (1)
- Higher education (1)
- Highly qualified workers (1)
- Highly siderophile elements (1)
- Hippocampal excitability (1)
- Hippocampus (1)
- Histological analysis (1)
- Histoplasma qPCR (1)
- Historiografia Argentina (1)
- Historische Diskursanalyse (1)
- History (1)
- História Contemporânea (1)
- História Intelectua (1)
- Hmox1 (1)
- HoLEP (1)
- Hochqualifizierte (1)
- Hochschulentwicklung (1)
- Hochschullehre (1)
- Hochschulschrift (1)
- Hodge bundle (1)
- Hodgkin lymphoma (1)
- Hodgkin’s lymphoma (1)
- Holography (1)
- Holzhausen-Porträtsammlung (1)
- Holznutzung (1)
- Homicide-suicide (1)
- Homizid-Suizid (1)
- Hope (1)
- Hospital case volume (1)
- Hospitalization (1)
- Host jump (1)
- House dust mite allergy (1)
- Household Consumption (1)
- Hsp70 (1)
- Human (1)
- Human immunodeficiency virus (HIV) (1)
- Human well-being (1)
- Hybrid Markets (1)
- Hybrid model (1)
- Hymenoptera venom immunotherapy (1)
- Hyperactivity (1)
- Hyperscanning (1)
- Hypochondriasis (1)
- Hyponatremia (1)
- Hypothetical bias (1)
- Hypoxia-inducible factor-1α (HIF-1α) (1)
- Höchstrichterliche Rechtsprechung (1)
- Höhle (1)
- I/O efficiency (1)
- ICAM-1 (1)
- ICD (1)
- ICD-11 (1)
- ICD11 (1)
- ICT (1)
- ICT Engagement (1)
- IDH1 inhibitor (1)
- IDO1 (1)
- IFA (1)
- IFN-γ expression (1)
- IKKε (1)
- IL-1β (1)
- IL-6 (1)
- IS post-adoption (1)
- ISPCE (1)
- ISR (1)
- IT infrastructure (1)
- IV estimation (1)
- IV iron (1)
- IVD degeneration (IVDD) (1)
- Ibagué (1)
- Identifikation (1)
- Identifizierung von Katastrophenopfern (1)
- Idiopathische Dystonie (1)
- IgG (1)
- Illegal wildlife trade (1)
- Image (1)
- Image processing (1)
- Image processing (computer-assisted) (1)
- Imam (1)
- Immune function (1)
- Immune suppression (1)
- Immune system (1)
- Immunity (1)
- Immunomodulatory agents (1)
- Immunotherapy (1)
- Implant osseointegration (1)
- Implementación (1)
- Implementation (1)
- Impostor phenomenon (1)
- In situ burning (1)
- In vivo (1)
- Incentives (1)
- Incremental validity (1)
- Incurred loss model (1)
- Index effect (1)
- Index investing (1)
- Index rebalancing (1)
- Individual (1)
- Individual investors (1)
- Indivíduo (1)
- Induced membrane technique (1)
- Inducible nitric oxide synthase (iNOS) (1)
- Induction chemotherapy (1)
- Industrial psychologists (1)
- Inequality (1)
- Inertial motion capture (1)
- Infectious diseases (1)
- Infektionen (1)
- Infektionsdynamik (1)
- Inferior colliculus (1)
- Inflammatory bowel disease (1)
- Inflammatory pattern (1)
- Information Frictions (1)
- Infrastruktur (1)
- Inhibitory balance (1)
- Inhibitory interneurons (1)
- Injury (1)
- Injury Severity Score (ISS) (1)
- Inklusive Bildung (1)
- Inklusive Hochschule (1)
- Innate immunity (1)
- Innenstadtverträglichkeit (1)
- Institutionelle Diskriminierung (1)
- Instructional quality (1)
- Instrumentalism (1)
- Integral Geometry (1)
- Integrated Pulmonary Index (1)
- Integritätsschutz (1)
- Intellectual History (1)
- IntelliCage (1)
- Intelligence (1)
- Intensive care (1)
- Interdealer Brokerage (1)
- Interdisciplinary research (1)
- Interdisziplinarität (1)
- Interferons (1)
- Interim Report (1)
- Internal Controls (1)
- International Law (1)
- International cooperation (1)
- International relations (1)
- Internationale Beziehungen (1)
- Internationale Institutionen (1)
- Internationalisierung (1)
- Interoperability (1)
- Interposition (1)
- Interpretation (1)
- Interstitial pneumonia (1)
- Intoxication (1)
- Intoxikation (1)
- Intravenous antibiotic therapy (1)
- Intravenous injections (1)
- Inversion (1)
- Invertebrates (1)
- Investor behavior (1)
- Iodine (1)
- Ion transport (1)
- Ipomoea beninensis (1)
- Iran (1)
- Ireb2 (1)
- Iron (1)
- Islamische Religionspädagogik (1)
- Islamische Theologie (1)
- Islamismus (1)
- Isocitrate dehydrogenase (1)
- Issue congruence (1)
- Izu-Bonin forearc (1)
- JIP-test (1)
- JNK (1)
- Japan (1)
- Jeanne d’Arc (1)
- Jet substructure (1)
- Job Match Quality (1)
- Jobticket (1)
- Joint actions (1)
- Joint loading (1)
- Journalismus (1)
- Jumping (1)
- Justification (1)
- K-homology RNA-binding domain (1)
- KI (1)
- KOOS IV (1)
- Kalkulation (1)
- Kampagne (1)
- Kamu Yönetimi (1)
- Karité (1)
- Kategorienarten (1)
- Ki-67/MIB1 (1)
- Ki67 transgenic c‐myc/TGFα mice (1)
- Kidney diseases (1)
- Kidney neoplasm (1)
- Kierkegaard (1)
- Kinase inhibitors (1)
- Kinder (1)
- Kinderbonus (1)
- Kinderrechte (1)
- Kinderrechtskonvention (1)
- Kinderwunsch (1)
- Kinematic analysis (1)
- Knees (1)
- Kognitive Beeinträchtigungen (1)
- Kohäsion (1)
- Kompetenzmodell (1)
- Konflikt (1)
- Konjunkturpolitik (1)
- Konsum (1)
- Kontexteinheit (1)
- Konzeptpapier (1)
- Kooperationsmodell (1)
- Kordyana (1)
- Krahl (1)
- Krankenhausfallaufkommen (1)
- Krankheit (1)
- Krankheitskosten (1)
- Krise (1)
- Kritische Theorie (1)
- Kultur (1)
- Kunstgeschichte (1)
- Kunstkritik (1)
- Kunstmarkt (1)
- Kur River Basin (1)
- Kursbuch (1)
- König, Johann (1)
- Körpermaße (1)
- Körpermodifizierung (1)
- K–12 (1)
- L-DOPA (1)
- LBP (1)
- LC3 (1)
- LETKF (1)
- LILBID-MS (1)
- LIR interaction, (1)
- LIR motif (1)
- LPS (1)
- Labor Income Risk (1)
- Lactobacillus (1)
- Lagos (1)
- Lamb waves (1)
- Land cover (1)
- Landarztprogramm (1)
- Langstreckige Knochendefekte (1)
- Language delay (1)
- Late gadolinium enhancement (1)
- Lattice Quantum Field Theory (1)
- Lauterkeitsrecht (1)
- Law (1)
- Law Enforcement (1)
- Law and Finance (1)
- Law and economics (1)
- Law and finance (1)
- Law enforcement (1)
- Learner goals (1)
- Learning analytics dashboard (1)
- Lebensstil (1)
- Lebenszeitverlust (1)
- Left hemisphere (1)
- Legal considerations (1)
- Legitimacy (1)
- Legs (1)
- Lehramt (1)
- Lehramtsausbildung (1)
- Lehrer*innenbildung (1)
- Lehrerbildung (1)
- Lehrerfortbildung (1)
- Lehrerprofession (1)
- Lenkungsabgabe (1)
- Lennox-Gastaut syndrome (1)
- Lepton-Nucleon Scattering (experiments) (1)
- Lernen mit Videos (1)
- Leukemia (1)
- Leukämie (1)
- Leverage (1)
- Liberal Democracy (1)
- Liberdade Social (1)
- Life cycle saving (1)
- Life insurance (1)
- Life-Cycle Model (1)
- Life-Satisfaction (1)
- Ligands (1)
- Light (anti-)(hyper-)nuclei production (1)
- Limonene-3-hydroxylase (1)
- Linkages (1)
- Lipodystrophy (1)
- Lipoxygenase (1)
- Liquid immiscibility (1)
- Liquidity Facilities (1)
- Literatur und Wissen (1)
- Literaturdidaktik (1)
- Literature review (1)
- Liver transplant (1)
- Loan loss accounting (1)
- Loan losses (1)
- Local IgE (1)
- Local allergic rhinitis (1)
- Locally advanced (1)
- Lockdown (1)
- Loco-regional control (1)
- Lodi Vecchio (1)
- Long non-coding RNAs (1)
- Longchain polyunsaturated fatty acids (1)
- Longevity (1)
- Longevity risk (1)
- Longitudinal study (1)
- Loranthaceae (1)
- Louis Althusser (1)
- Loving kindness meditation (1)
- Low & intermediate-energy accelerators (1)
- Low-copy nuclear gene (1)
- Low-dose ionizing radiation (1)
- Low-dose radiation therapy (1)
- Lower back pain (1)
- Ludwig Boltzmann (1)
- Lung cancer (1)
- Lung development (1)
- Lung function (1)
- Lung ultrasound (1)
- Lungenerkrankungen (1)
- Luther, Martin (1)
- Lymph nodes (1)
- Lymphocytes (1)
- Lymphoma (1)
- Lysophosphatidic acids (1)
- Längsschnitt (1)
- M. Intracellulare (1)
- M. avium (1)
- M. avium complex (1)
- M. chimaera (1)
- MAGGIC score (1)
- MAPK6 (1)
- MCAO (1)
- MET (1)
- MFS-type tripartite system (1)
- MHC (1)
- MICA (1)
- MM-121 (1)
- MMP14 (1)
- MODY (1)
- MR-spectroscopy (1)
- MS (1)
- MVPA (1)
- MYC (1)
- Machine learning algorithms (1)
- Machine teaching (1)
- Machine-learning (1)
- Macroautophagy (1)
- Macrodomain (1)
- Macroeconomics (1)
- Macrophage polarization (1)
- Mailand (1)
- Mainz (1)
- Malaria (1)
- Mammakarzinom (1)
- Management (1)
- Managerial roles (1)
- Marantaceae (1)
- Marcuse (1)
- Marke (1)
- Markeninszenierung (1)
- Marker genes (1)
- Market Access (1)
- Market Integrity (1)
- Market Microstructure (1)
- Market Oversight (1)
- Market research (1)
- Marketing (1)
- Martin Luther (1)
- Marxian economics (1)
- Masquelet technique (1)
- Mass disaster (1)
- Mass spectrometry (1)
- Mass-elite (1)
- Massenkatastrophe (1)
- Massenspektrometrie (1)
- Massive Analysis of cDNA Ends (MACE) (1)
- Master Plan 2020 (1)
- Masterplan 2020 (1)
- Materialitäten (1)
- MathCityMap (1)
- Mathematical models (1)
- Mathematics teaching (1)
- Mathematikdidaktik (1)
- Mathematikunterricht (1)
- Mathtrails (1)
- Max Weber (1)
- Maxillofacial surgery (1)
- Maßnahme (1)
- Mdm2 (1)
- Mean erythrocyte volume (1)
- Meaning of work (1)
- Meaningful work (1)
- Meaningful work-role fit (1)
- Measurement (1)
- Mechanistic (1)
- Media Temporality (1)
- Medialität (1)
- Medical education (1)
- Medical implants (1)
- Medical law (1)
- Medical risk factors (1)
- Medical studies (1)
- Medienbildung (1)
- Mediennutzungsforschung (1)
- Medienwissenschaft (1)
- Medienästhetik (1)
- Medizin (1)
- Medizinrecht (1)
- Medizinstudierende (1)
- Medizinstudium (1)
- Mehrwertsteuersenkung (1)
- Meinungsfreiheit (1)
- Meldepflicht (1)
- Membrane potential (1)
- Membrane proteins (1)
- Memoiren (1)
- Memory (1)
- Memory consolidation (1)
- Memory quality (1)
- Menschenrechte (1)
- Menschenwürde (1)
- Mental health (1)
- Mental health and psychiatry (1)
- Mental imagery (1)
- Mesenchymal stromal cells (MSC) (1)
- Mesh (1)
- Mesoporous silica (1)
- Messel Formation (1)
- Messenger RNA (1)
- Metabolic diseases (1)
- Metabolism (1)
- Metapher (1)
- Metasomatism (1)
- Metastatic (1)
- Methoden (1)
- Methodenpluralismus (1)
- Methodological pluralism (1)
- Methodologie (1)
- Metta (1)
- Mexico (1)
- Mexiko (1)
- Michael acceptor (1)
- Michel Leiris (1)
- Michelsberg (1)
- Micro-Processes (1)
- MicroRNA-181a (1)
- Microbial Rhodopsins (1)
- Microbial ecology (1)
- Microbiology (1)
- Microbiome (1)
- Microfluidics (1)
- Microglial cells (1)
- Microparticles (1)
- Microphysiological models (1)
- Microplastic (1)
- Microstates (1)
- Microthlaspi erraticum (1)
- Middle Miocene (1)
- Midwifery (1)
- Mika Rottenberg (1)
- Mimesis (1)
- Minima Moralia (1)
- Minimally invasive surgical procedures (1)
- Minor injury (1)
- Minutis rectis laws (1)
- Mississippi basin (1)
- Mitigation (1)
- Mitochondrial dysfunction (1)
- Mitophagy (1)
- MitraClip (1)
- Mixed Method Research (1)
- Mixture toxicity (1)
- Mobile (1)
- Mobile Learning (1)
- Mobile platforms (1)
- Mobility design (1)
- Mobilitätsdesign (1)
- Mobilitätserhebung (1)
- Mobilitätsverhalten (1)
- Mobilization (1)
- Model (1)
- Modellierung situationsspezifischer Fähigkeigkeiten (1)
- Modern societies (1)
- Modulprüfung (1)
- Mole-rat (1)
- Molecular Physiology of the Cell Membrane (1)
- Molecular autopsy (1)
- Molecular biology (1)
- Molecular diagnostic testing (1)
- Molecular neuroscience (1)
- Mollusks (1)
- Monetary incentive delay (1)
- Money (1)
- Mongolian spot (1)
- Monitoring (1)
- Monocytes (1)
- Monoterpenoid (1)
- Monoterpenoid tolerance (1)
- Monte-Carlo simulations (1)
- Morena, Otto (1)
- Morphologie (1)
- Motivational situation (1)
- Motivationslage (1)
- Motor control (1)
- Motor cortex (1)
- Mouse models (1)
- Mucomaix® matrix (1)
- Muji (1)
- Multidrug-resistance (1)
- Multilateralism (1)
- Multimedication (1)
- Multimorbidity (1)
- Multiparametric MRI (1)
- Multiplate (1)
- Multiple Sklerose (1)
- Multiple stressors (1)
- Multiple-indication review (1)
- Mundellian trilemma (1)
- Mundhöhlenkarzinome (1)
- Muscle functions (1)
- Musculoskeletal diseases (1)
- Museum Giersch Frankfurt (1)
- Museum studies (1)
- Music (1)
- Musical education (1)
- Muskuloskelettale Erkrankungen (1)
- Mutation databases (1)
- Muttermilch (1)
- Mutual information (1)
- Myanmar (1)
- Myocardial infarction (MI) (1)
- Myocardial injury (1)
- Myocardial segmentation (1)
- Myonecrosis (1)
- Música (1)
- Mφs (1)
- N-glycoproteome (1)
- N2 (1)
- N400 (1)
- NAFL (1)
- NATO (1)
- NAV-price-spread (1)
- NCOA4 (1)
- NCoR1 (1)
- NDBI (1)
- NF-κB (1)
- NF-κB pathway (1)
- NF-кB (1)
- NGOs und Machtverhältnisse (1)
- NGS (1)
- NHC (1)
- NIRS (1)
- NK-ZELL-BASIERTER IMMUNTHERAPIE (1)
- NK-ZELLEN (1)
- NKG2D (1)
- NLP (1)
- NLRP3 inflammasomes (1)
- NMES (1)
- NMR solution structure (1)
- NOTCH (1)
- NPH insulin (1)
- NREM sleep (1)
- NRPS engineering (1)
- NS1608 (1)
- NSE (1)
- NSU (1)
- NTM (1)
- Nachtschattengewächs (1)
- Nachwuchsförderung (1)
- Nahes Ausland (1)
- Narendra Modi (1)
- Nascent ventures (1)
- National Socialist Underground (1)
- Nationalsozialismus (1)
- Nationalsozialistischer Untergrund (1)
- Nationalversammlung (1)
- Natur (1)
- Natur und Umwelt (1)
- Natural hazards (1)
- Natural products (1)
- Natural sounds (1)
- Nature Contributions to People (1)
- Nature Valuation (1)
- Nature reserve (1)
- Necrotizing fasciitis (1)
- Negative appendectomy rate (1)
- Nek1 (1)
- Neonatal brain damage (1)
- Neonatal surgery outcome (1)
- Neostriatum (1)
- Nephrectomy (1)
- Nesplora Aquarium (1)
- Network models (1)
- Network motifs (1)
- Networking (1)
- NetzDG (1)
- Netzwerkdurchsetzungsgesetz (1)
- Neue Kriege (1)
- Neural circuits (1)
- Neural networks (1)
- Neurath (1)
- Neurocognition (1)
- Neurodegeneration (1)
- Neurodevelopmental disorders (1)
- Neuron (1)
- Neuronal plasticity (1)
- Neuropathic pain (1)
- Neurophysiology (1)
- Neuropsychological testing (1)
- Neuropsychology (1)
- Neuroscience (1)
- Neurosurgery (1)
- Neurotransmitter (1)
- Nevus of Ito (1)
- Nevus of Ota (1)
- New Development Bank (1)
- New Great Game (1)
- New host (1)
- New product development processes (1)
- New wars (1)
- Next-generation sequencing (1)
- Nf2 (1)
- Niche (1)
- Nichteinmischung (1)
- Nicotine (Nicotiana tabacum/ Nicotiana rustica) (1)
- Nicotinic acetylcholine receptors (1)
- Niedrigzinsen (1)
- Nikotin (Nicotiana tabacum/ Nicotiana rustica) (1)
- Nikotinerge Acetylcholinrezeptoren (1)
- Nivolumab (1)
- Nok Culture (1)
- Non Refoulement (1)
- Non-Monetary Surplus Values (1)
- Non-abusive head trauma (NAHT) (1)
- Non-allergic-rhinitis (1)
- Non-apoptotic functions (1)
- Non-clear cell renal cell cancer (1)
- Non-invasive sampling (1)
- Non-motorised travel (1)
- Non-small cell lung cancer (1)
- Non-tuberculous mycobacteria (1)
- Non-vitamin K antagonist oral anticoagulants (1)
- Nonlinear Bayesian Estimation (1)
- Nonlocal Neumann conditions (1)
- Nonlocal normal derivative (1)
- Nordic questionnaire (1)
- Normabweichung (1)
- Normal distribution (1)
- Normative Orders (1)
- Normative Ordnung (1)
- Normative Ordnungen (1)
- Normative modeling (1)
- Normative reconstruction (1)
- Normativität (1)
- Notch signaling (1)
- Novel Object Test (1)
- NoxO1 (1)
- Nucleic acid-binding domain (1)
- Nucleocapsid (1)
- Nukleinsäuren (1)
- Number of platelets (1)
- Nutzung (1)
- Nutzungskriterien (1)
- N‐fixer (1)
- O-CAS assay (1)
- OEP80 (1)
- OGTT (1)
- OR time (1)
- OSA (1)
- OTC Markets (1)
- OTSC Proctology (1)
- OTU domain-containing protein 7B (OTUD7B) (1)
- OVKS (1)
- Obduktion (1)
- Oberstufe (1)
- Obsessive-compulsive disorder (1)
- Obstetrics (1)
- Occurrence (1)
- Offender treatment (1)
- Offline advertising (1)
- Olpidiopsis (1)
- Omar Mukhtar (1)
- Omphalocele (1)
- Oncology (1)
- Online-Forschung (1)
- Online-Umfrage (1)
- Onlineforschung (1)
- Oocytes (1)
- Oomycetes (1)
- Open-end real estate funds (1)
- OpenStreetMap (1)
- Opioids (1)
- Oppositional defant disorder (1)
- Optical properties and devices (1)
- Optimal matching techniques (1)
- Oral anticoagulation (1)
- Oral cancer (1)
- Organisationsentwicklung (1)
- Organische Synthese (1)
- Organizational injustice (1)
- Organoboranes (1)
- Organoids (1)
- Organokatalyse (1)
- Orphan nuclear receptor (1)
- Orthognathic surgery (1)
- Oryctolagus cuniculus (1)
- OspE (1)
- Osteoarthritis (1)
- Osteonecrosis (1)
- Otto, Frisingensis (1)
- Outcomes (1)
- Ovarian cancer treatment (1)
- Ovarielle Reserve (1)
- Ovaries (1)
- Ovartoxizität (1)
- Overwintering (1)
- Oxidative stress (1)
- Oxygen (1)
- PARK2 (1)
- PBMC (peripheral blood mononuclear cells) (1)
- PBPK/PD (1)
- PCA (1)
- PD-1 inhibitor (1)
- PDE inhibition (1)
- PDE‐5‐inhibitor (1)
- PEA-15 (1)
- PELDOR/DEER spectroscopy (1)
- PEPP (1)
- PHGDH (1)
- PI3K/mTor inhibition (1)
- PKD (1)
- PKD/IC (1)
- PLSC (1)
- PPEP (1)
- PRNT (1)
- PROM (1)
- PROTAC (1)
- PRRT2 (1)
- PSA screening (1)
- PSA-Screening (1)
- PV loop (1)
- PWI (1)
- PYGL (1)
- Paediatric trauma patients (1)
- Paid search advertising (1)
- Pain (1)
- Pain management (1)
- Pain sensation (1)
- Palaeoceanography (1)
- Palaeoclimate (1)
- Paleoclimate (1)
- Palliative care (1)
- Panama (1)
- Panthera onca (1)
- Pantürkismus (1)
- Parasitismus (1)
- Parasympathetic (1)
- Paris (1)
- Parking policy (1)
- Parking restrictions (1)
- Parking space (1)
- Parkinson's disease (1)
- Partial chemical equilibrium (1)
- Particle correlations and fluctuations (1)
- Partizipative Lehre (1)
- Passeriformes (1)
- Passive investment (1)
- Patch Clamp (1)
- Patents (1)
- Pathogenesis (1)
- Pathologists (1)
- Patient information materials (1)
- Patient outcome assessment (1)
- Patient reported outcomes (1)
- Patient safety (1)
- Pb isotopes (1)
- Peanut allergy (1)
- Pediatric patients (1)
- Peer Learning (1)
- Peer review (1)
- Pelvic (1)
- Peracarida (1)
- Perception (1)
- Percolation theory (1)
- Percutaneous endoscopic gastrostomy (1)
- Perfect graphs (1)
- Perfectionism (1)
- Perfectionistic concerns (1)
- Perfectionistic strivings (1)
- Performance Metrics (1)
- Pericardial effusion (1)
- Pericarditis (1)
- Periodontitis grades B and C (1)
- Periprocedural anticoagulation (1)
- Permeation and transport (1)
- Peronospora belbahrii (1)
- Peronospora lamii (1)
- Peronospora salviae-officinalis (1)
- Peronosporaceae (1)
- Perrault syndrome (1)
- Persistent and Transitory Income Shocks (1)
- Persistent depressive disorder (1)
- Personal (1)
- Personality traits (1)
- Persönlichkeit (1)
- Pexophagy (1)
- Pgrmc1 (1)
- Phalangeal fractures (1)
- Pharma Management (1)
- Pharmaceutical (1)
- Pharmacology (1)
- Phase I clinical trial (1)
- Phase II trial (1)
- Phase rotors (1)
- Phase transitions (1)
- Phenotypic plasticity (1)
- Philemon and Baucis (1)
- Philemon und Baucis (1)
- Phosphoproteome (1)
- Photon counting (1)
- Physical activity (1)
- Physical chemistry (1)
- Physical oceanography (1)
- Physician-assisted suicide (1)
- Physicians (1)
- Physics (1)
- Physiologically Based Pharmacokinetic Modelling (1)
- Pim-1 (1)
- Plant collections (1)
- Plantagearbeiter (1)
- Plantation workers (1)
- Plasma transfusion (1)
- Plasma usage (1)
- Plastic polymers (1)
- Platelet-rich fibrin (1)
- Platinum-group elements (1)
- Plecoptera (1)
- Pliocene–Pleistocene (1)
- Podospora anserina (1)
- Poecilia (1)
- Pokémon Go (1)
- Policy Analysis (1)
- Policy Effects (1)
- Policy measures in the EU (1)
- Policy preferences (1)
- Policy recommendations (1)
- Political violence (1)
- Politikberatung (1)
- Politikwissenschaft (1)
- Politische Gewalt (1)
- Politische Kollektivität (1)
- Politische Soziologie (1)
- PolySUMOylation (1)
- Polycyclic aromatic hydrocarbons (1)
- Polygenic risk score (1)
- Polypedates (1)
- Polypharmacy (1)
- Polysomnography (1)
- Polytrauma (1)
- Pond snail (1)
- Poor literacy (1)
- Population dynamics (1)
- Populismus (1)
- Portable XRF (1)
- Portal hypertension (1)
- Portal veins (1)
- Portfolio (1)
- Position of Antecedent strategy (1)
- Positive polynomials (1)
- Positive reinforcement training (1)
- Post mortem interval (1)
- Post-traumatic stress disorder (1)
- Postdemokratie (1)
- Posture (1)
- Postwachstum (1)
- Potential analysis (1)
- Pp (1)
- Ppk (1)
- Praktisches Jahr (1)
- Pre-service PE teacher education (1)
- PreS1 deletion (1)
- Precipitation inhibition (1)
- Preclinical drug development (1)
- Predictability (1)
- Prediction (1)
- Predictive Policing (1)
- Predictive coding (1)
- Predictive validity (1)
- Preference Stability (1)
- Preference for early resolution of uncertainty (1)
- Premotor cortex (1)
- Presidential Debate (1)
- Pressure distribution (1)
- Pressure measuring plate (1)
- Prevalence (1)
- Prevention (1)
- Pre‐Ligand Assembly Domain (PLAD) (1)
- Pricing (1)
- Primary breast lymphoma (1)
- Primary care (1)
- Primary health care (1)
- Privacy (1)
- Private Altersvorsorge (1)
- Private equity (1)
- Private ordering (1)
- Privatwirtschaft (1)
- Privileg (1)
- Probability density (1)
- Probability distribution (1)
- Procalcitonin (1)
- Procedural skills (1)
- Proceduralism (1)
- Process Capability (1)
- Process Performance (1)
- Process Validation (1)
- Productivity and Growth (1)
- Profession (1)
- Professional competence (1)
- Professional development program (1)
- Professionelle Handlungskompetenz (1)
- Professions (1)
- Profits and distribution (1)
- Progestatifs synthétiques (1)
- Prolonged grief disorder (1)
- Promoting young researchers (1)
- Prostata-specific antigen (1)
- Prostataspezifisches Antigen (1)
- Prostate cancer (1)
- Protease inhibitor therapy (1)
- Proteasome inhibitor (1)
- Protein Kinase (1)
- Protein Structure and Dynamics (1)
- Protein druggability (1)
- Protein folding (1)
- Protein translation (1)
- Proteins (1)
- Protest (1)
- Protestantism (1)
- Proton-proton collisions (1)
- Prototypes (1)
- Proust (1)
- Prudential filter (1)
- Prudential oversight (1)
- Präanalytik (1)
- Prävention (1)
- Pseudomonas putida (1)
- Pseudoprogression (1)
- Pseudouridine (1)
- Pseudouridylation (1)
- Psycho-oncology (1)
- Psychological and psychosocial issues (1)
- Psychological disorders (1)
- Psychological stress (1)
- Psychologische Beeinträchtigung (1)
- Psychology (1)
- Psychopharmaka (1)
- Psychosocial impact (1)
- Pteridine (1)
- Public Administration (1)
- Public Transport (1)
- Public-Private Partnerships (1)
- Pulmonary edema (1)
- Pulmonary embolism (1)
- Pulmonary hypertension (1)
- Pulmonary hypoplasia (1)
- Puromycin (1)
- Put-back (1)
- Pyramidal neurons (1)
- Pyrolysis GC–MS (1)
- Pädagogische Professionalität (1)
- Pérdida (1)
- QCA (1)
- QCD Phenomenology (1)
- QCD equation of state (1)
- QOL (1)
- Qb-Test (1)
- QbTest® (1)
- Qualitative research (1)
- Quality Control (1)
- Quality control (1)
- Quality indicators (1)
- Qualitätsindikatoren (1)
- Quantenphysik (1)
- Quantitative (q)T2 mapping (1)
- Quantitative easing (1)
- Quantitative magnetic resonance imaging (1)
- Quantitative research (1)
- Quantra (1)
- Quarantine (1)
- Questionnaire (1)
- Questionnaires (1)
- Quinolones (1)
- R406 (1)
- RAS (1)
- RBC (1)
- RBFOX1 (1)
- RDA, Digital Object Architecture (1)
- RDoC (1)
- REM sleep (1)
- RIPK1 (1)
- RNA chaperone (1)
- RNA induced silencing complex (1)
- RNA recognition (1)
- RNA therapeutics (1)
- RNA-binding proteins (RBPs) (1)
- RNA-protein complex (RNP) (1)
- RNA-seq (1)
- RNAseq analysis (1)
- RNF4 (1)
- RNP dynamics (1)
- RRMS (1)
- RUCAM (1)
- RULA (1)
- Rab27a (1)
- Radiation exposure (1)
- Radical cystectomy (1)
- Radiotherapy (1)
- Radiothérapie (1)
- Rain (1)
- Rainer Forst (1)
- Ramadan (1)
- Random graphs (1)
- Randomised trial (1)
- Randomized controlled trial (1)
- Randomized controlled trials (1)
- Randomized trial (1)
- Rapid diagnostic test (1)
- Rapid rotation (1)
- Rational agency (1)
- Raum (1)
- Raunkiær (1)
- Reaction times (1)
- Real-time phase contrast (1)
- Realismus (1)
- Reallabor (1)
- Reallocation (1)
- Reason (1)
- Reasoning (1)
- Recht (1)
- Rechtliche Würdigung (1)
- Rechtsschutz (1)
- Recognition memory (1)
- Recolonization (1)
- Reconstrução normativa (1)
- Rectal cancer (1)
- Reference values (1)
- Referenzwerte (1)
- Referrals (1)
- Reflections (1)
- Reflexive polytopes (1)
- Reflexivität (1)
- Reflexões (1)
- Refractory ALL (1)
- Refractory AML (1)
- Refugee Protection (1)
- RegJoint™ (1)
- Regeneration (1)
- Region Hannover (1)
- Regional Laplacian (1)
- Regret (1)
- Regulation (1)
- Regulatory Affairs (1)
- Reintroduction (1)
- Relativistic heavy-ion collisions (1)
- Relaxometrie (1)
- Relações sociais e políticas (1)
- Reliability (1)
- Religionspädagogik (1)
- Renaissance (1)
- Renal replacement therapy (1)
- Representación (1)
- Reproduktionszahlen (1)
- Repräsentationen (1)
- Republican coinage (1)
- Requirements (1)
- Rescue medication (1)
- Research & Development (1)
- Research Data Alliance (1)
- Research Data Management rights copyright (1)
- Research Infrastructure (1)
- Research and market linkages (1)
- Research investment (1)
- Research methods (1)
- Resolution (1)
- Respiratory distress syndrome (1)
- Resting-state (1)
- Retinal diseases (1)
- Retinoic acid (1)
- Retirement (1)
- Retirement Welfare (1)
- Retrospective studies (1)
- Return to work (1)
- Review (1)
- Reward (1)
- Rezension (1)
- Rezidiv (1)
- Rhabdomyosarkom (1)
- Rheumatoid arthritis (1)
- Rhodococcus rhodnii (1)
- Ribonucleoproteins (1)
- Riester-Rente (1)
- Right hemisphere (1)
- Risk Attitudes (1)
- Risk Aversion (1)
- Risk Pooling (1)
- Risk Preferences (1)
- Risk assessment (1)
- Risk factors (1)
- Risk sharing (1)
- Risk-stratification (1)
- Robert Kurz (1)
- Robot acceptance (1)
- Robotik (1)
- RogueBlock (1)
- Romanistik (1)
- Rome (1)
- Roussel Uclaf Causality Assessment Method (1)
- Roux-en-Y gastric bypass (1)
- Rule of Law (1)
- Running (1)
- Rush protocol (1)
- Russland (1)
- Récidive (1)
- République romaine (1)
- Réserve ovarienne (1)
- Rücklaufquote (1)
- S100b (1)
- S1P lyase (1)
- S1P receptors (1)
- S1P1–5 (1)
- S1PR4 (1)
- SAR (1)
- SARS‐CoV‐2 (1)
- SCA2 (1)
- SCN5A (1)
- SEAP (1)
- SENP (1)
- SENP6 (1)
- SF-36 (1)
- SIDS (1)
- SIRS (1)
- SKI II (1)
- SLC20A1 (1)
- SLUG (1)
- SMAD (1)
- SMART targets (1)
- SNORD95 (1)
- SOFI (1)
- SOZ (1)
- SPAD (1)
- SPAdes (1)
- SPC (1)
- SPR (1)
- SPSS (1)
- STAT3 (1)
- STS (1)
- SUMO (1)
- SUMO chains (1)
- SWOT (1)
- Safety (1)
- Saha equation (1)
- Sales (1)
- Sammelalben (1)
- Sammelbilder (1)
- Sammlungsgeschichte (1)
- Sarcoidosis (1)
- Sarcomas (1)
- Sarkoidose (1)
- Saudi Arabia (1)
- Scaffold (1)
- Scales (1)
- Schadensindex (1)
- Schibutterbaum (1)
- Schizokinen (1)
- Schlaganfall (1)
- Schmerz (1)
- Schule (1)
- Schulentwicklung (1)
- Schulforschung (1)
- Schulleitung (1)
- Schwefelwasserstoff (1)
- Schweiz (1)
- Schädel-MRT (1)
- Schüler (1)
- Search Frictions (1)
- Seattle heart failure model (1)
- Second Law of Thermodynamics (1)
- Second Punic War (1)
- Second donation (1)
- Second-order cone (1)
- Secondary market (1)
- Secular trend (1)
- Security (1)
- Sediment (1)
- Selbstmordpakt (1)
- Self-Congruity Theory (1)
- Self-compassion (1)
- Self-esteem (1)
- Self-expandable TAVI (1)
- Self-kindness (1)
- Self-regulated learning (1)
- Seltene Erkrankungen (1)
- Semantics (1)
- Semitendinosus tendon autograft (1)
- Sens du travail (1)
- Sense-making (1)
- Sensitivität (1)
- Sensorimotor processing (1)
- Sensory processing (1)
- Sentiment Analysis (1)
- Sepsis (1)
- Sequence analyses (1)
- Sequence motif analysis (1)
- Seribantumab (1)
- Serin (1)
- Serious injured children (1)
- Seroconverter (1)
- Seroprevalence (1)
- Serum biomarker (1)
- Sex (1)
- Sexual offenders (1)
- Sexualstraftäter (1)
- Sharp injuries (1)
- Shea (1)
- Shopping centres (1)
- Shotgun sequencing (1)
- Shoulder injury (1)
- Shoulder luxation (1)
- Sialic acid (1)
- Sialinsäure (1)
- Sicherheit (1)
- Side effects (1)
- Siegfried Kracauer (1)
- Signal inhibition (1)
- Signal intensity (1)
- Signed Birkhoff polytopes (1)
- Signs and symptoms (1)
- Silacyclobutenes (1)
- Silanide (1)
- Silicon (1)
- Silver (1)
- Silylation (1)
- Simulation (1)
- Single question approach (1)
- Single-Molecule Localization Microscopy (SMLM) (1)
- Sinn in der Arbeit (1)
- Sinnvolle Arbeit (1)
- Skewness (1)
- Skin morphology (1)
- Slc11a2 (1)
- Slc25a37 (1)
- Sleep (1)
- Sleep deprivation (1)
- Smac mimetic (1)
- Small molecules (1)
- Smart City (1)
- Smart Contracts (1)
- Smartphone (1)
- Social Networks (1)
- Social System (1)
- Social and political relations (1)
- Social anxiety disorder (1)
- Social behaviour (1)
- Social brain (1)
- Social differences (1)
- Social freedom (1)
- Social information processing (1)
- Social insects (1)
- Social participation (1)
- Social signaling (1)
- Social stressors (1)
- Social support (1)
- Sociedade Administrada (1)
- Sociedades modernas (1)
- Society Administered (1)
- Socio-economic analysis (1)
- Socioeconomic analysis (1)
- Socioeconomic indices (1)
- Sociologie du travail (1)
- Sociology (1)
- Sociology of work (1)
- Sodium transport (1)
- Soft tissue infection (1)
- SoftDrop (1)
- Software tools (1)
- Software updates (1)
- Solanaceae (1)
- Solanum lycopersicum (1)
- Solanum lycopersicum L. (1)
- Solid Oral Dosage Forms (1)
- Solid dispersion (1)
- Solubility (1)
- Sorting nexins (1)
- Southeast Asia (1)
- Southern Ndebele (1)
- Southern Ocean (1)
- Sovereign credit risk (1)
- Soziale Bewegungen (1)
- Soziale Interaktionen (1)
- Sozialontologie (1)
- Sozialwissenschaften (1)
- Spanien (1)
- Spanish (1)
- Spanish reproductive bioeconomy (1)
- Speech (1)
- Spezifität (1)
- Spine fractures (1)
- Spinocerebellar ataxia type 2 (1)
- Splitting function (1)
- Sportlehrkräftebildung (1)
- Sports and exercise medicine (1)
- Sprachbiographie (1)
- Spracherwerb (1)
- Sprachförderkompetenz (1)
- Sprachförderung (1)
- Sprachkompetenz (1)
- Sraffian economics (1)
- StUbL (1)
- Staatsangehörigkeitsrecht (1)
- Staatskollaps (1)
- Staatszerfall (1)
- Stadt (1)
- Stadtentwicklung (1)
- Stage at presentation (1)
- Stage model (1)
- Stages (1)
- Staging mobilities (1)
- Standard dataset (1)
- Standard reference values (1)
- Standard value (1)
- Stanley Cavell (1)
- Start-ups (1)
- State collapse (1)
- State of Control (1)
- Statisitcal Control (1)
- Statisitcal Process Control Chart (1)
- Statistical data (1)
- Statistical multifragmentation models (1)
- Statistical theory and fluctuations (1)
- Status epilepticus (1)
- Stauferzeit (1)
- Stay-Home (1)
- Stem cell (1)
- Stem cells (1)
- Stereoelektroenzephalographie (1)
- Stereotaxie (1)
- Sternenbild (1)
- Sterols (1)
- Steuer (1)
- Stichtagserhebung (1)
- Stiffness (1)
- Stock Markets (1)
- Stock market wealth (1)
- Stockholding (1)
- Stratosphere (1)
- Streptokokken (1)
- Stress (1)
- Striatum (1)
- Stroke genetics (1)
- Structural biology (1)
- Structural protein (1)
- Structured retail products (1)
- Student-facing learning analytics (1)
- Studienentscheidung (1)
- Studierende (1)
- Städtische soziale Bewegungen (1)
- Störfaktoren (1)
- Sub-segmentation (1)
- Sub-zero exposure (1)
- Subjective Well-Being (1)
- Subterranean (1)
- Subvalent compounds (1)
- Sudden death (1)
- Sudden infant death syndrome (1)
- Sums of non-negative circuit polynomials (1)
- Sunitinib (1)
- Supersaturation (1)
- Supervisory Achitecture (1)
- Supported Decision-making (1)
- Supreme court ruling (1)
- Surface range (1)
- Surface water (1)
- Surgeons (1)
- Surgery (1)
- Surgical and invasive medical procedures (1)
- Surgical therapy (1)
- Surrealism (1)
- Survey (1)
- Suspension (1)
- Sustainability (1)
- Sustainable Investments (1)
- Svalbard (1)
- Swallowing (1)
- Swimming behavior (1)
- Syllables (1)
- Symbolik des Bösen (1)
- Sympathetic (1)
- Symptome (1)
- Synaptic plasticity (1)
- Synaptic transmission (1)
- Synchronization (1)
- Synechocystis sp. PCC6803 (1)
- Synthetic methods (1)
- Synthetische Gestagene (1)
- Systematic reviews (1)
- Systematics (1)
- Systematik (1)
- Szientometrie (1)
- Säkularer Trend (1)
- T cell receptor (1)
- T cells (1)
- T-Zellen (1)
- T-cell receptor (1)
- T-tubule system (1)
- T1 and T2 mapping (1)
- T2 (1)
- TAMs (1)
- TAPSE (1)
- TBK1 (1)
- TBSS (1)
- TDM (1)
- TGF-beta (1)
- TGF-β (1)
- TGFβ (1)
- TGR(mREN2)27 (1)
- THV (1)
- THz detection (1)
- TIC (1)
- TLR2/6 (1)
- TPSC (1)
- TRIMs (1)
- TRPA1 (1)
- TSC22D3 (1)
- TVT (1)
- Tabakkonsum (1)
- Tabanidae (1)
- Tabanus (1)
- Tagging (1)
- Tamponade (1)
- Target validation (1)
- Targeted sequencing (1)
- Taxonomy (1)
- Tchad (1)
- Teacher-Education (1)
- Teachers’ Beliefs (1)
- Technik (1)
- Technique (1)
- Temsirolimus (1)
- Tendon incontinence repair (1)
- Tendon transplantation (1)
- Tendons (1)
- Tennis player (1)
- Teoria do Cinema (1)
- TeraFET (1)
- Terahertz optics (1)
- Terminology (1)
- Terpenoid (1)
- Terrorismus (1)
- Test assay (1)
- Testung situationsspezifischer Fähigkeiten (1)
- Text Annotation (1)
- Text2Scene (1)
- TextAnnotator (1)
- Textverstehen (1)
- Tfrc (1)
- Theater (1)
- Themenklassifikation (1)
- Theodor W. Adorno (1)
- Theologie (1)
- Theorie (1)
- Theorie-Praxis-Verzahnung (1)
- Therapie (1)
- Therapies (1)
- Therapy (1)
- Thermoanaerobacter kivui (1)
- Thermoregulation (1)
- Thin slices ratings (1)
- Thrombotic thrombocytopenic purpura (1)
- Thrombozytenkonzentrat (1)
- Thrombozytentransfusion (1)
- Thumb carpometacarpal joint osteoarthritis (1)
- Tigers (1)
- Tigray (1)
- Time Preferences (1)
- Tissue engineering (1)
- Toc75-V (1)
- Tocilizumab (1)
- Todesart (1)
- Toll-like receptor (1)
- Tomography (1)
- Tonsillitis (1)
- Tontines (1)
- Topologische Zustände (1)
- Torque (1)
- Total hip arthroplasty (1)
- Touchscreen (1)
- Toxic units (1)
- Toxicité ovarienne (1)
- Trade sales (1)
- Trading restrictions (1)
- Trading strategy (1)
- Training history (1)
- Transcatheter Aortic Valve Implantation (1)
- Transcription regulation (1)
- Transcriptional regulatory elements (1)
- Transcriptome analysis (1)
- Transferzahlungen (1)
- Transformation (1)
- Transformation problem (1)
- Transfusion practice (1)
- Transfusionszwischenfall (1)
- Transgenic mice (1)
- Transitional cell carcinoma (1)
- Translation proteomics (1)
- Transportation (1)
- Trastorno de duelo complejo persistente (1)
- TraumaRegister DGU® (TR-DGU) (1)
- Travail et subjectivité (1)
- Travail intéressant (1)
- Travel behaviour (1)
- Treatment costs (1)
- Treatment effectiveness (1)
- Treatment modification (1)
- Treatment rates (1)
- Treg (1)
- Treg cell (1)
- Trend Analysis (1)
- Triatominae (1)
- Triel (1)
- Tropical geometry (1)
- Trump (1)
- Trustworthiness (1)
- Trypanosoma cruzi (1)
- Tumor marker (1)
- Tumor microenvironment (1)
- Tumormarker (1)
- Tumormikromilieu (1)
- Type 2 diabetes (1)
- Type of death (1)
- Typicality (1)
- Técnica (1)
- Türkei (1)
- Türkenwelt (1)
- U2-OS (1)
- UBA domain (1)
- UBL (1)
- UDRP (1)
- UGP-Richtlinie (1)
- ULK4 (1)
- UPPS (1)
- USA (1)
- USP28 (1)
- UV/Vis spectroscopy (1)
- UWG (1)
- Ubiquitin (1)
- Ubiquitin ligase (1)
- Ubiquitinome (1)
- Udachnaya pipe (1)
- Ulcerative colitis (1)
- Ultra-rush protocol (1)
- Ultrakalte Quantengase (1)
- Umfrage (1)
- Umpolung (1)
- Umweltfreundliche Stadtpolitik (1)
- Unc-51-like kinase (1)
- Uncertainty (1)
- Unconditional polytopes (1)
- Unconventional Monetary policy (1)
- Undergraduate education (1)
- Undergraduates (1)
- Unfälle (1)
- Unimodular triangulations (1)
- Uniqlo (1)
- Unity (1)
- Universität (1)
- Unternehmen (1)
- Unterrichtsvideos (1)
- Upper body posture (1)
- Urban Studies (1)
- Urban development (1)
- Urban neighborhood (1)
- Urbanism (1)
- Urca processes (1)
- Urheberpersönlichkeitsrecht (1)
- Urmia Lake (1)
- Urnfield Culture (1)
- Urothelial cancer (1)
- Ursus arctos (1)
- Utopy (1)
- VHH (1)
- VIGALL (1)
- VIH/sida (1)
- VIM (1)
- VLA4 (1)
- VLCC (1)
- Validitätsbedrohungen (1)
- Valuation Theory (1)
- Valuation on functions (1)
- Value (1)
- Values (1)
- Vascular endothelial growth factor (VEGF) (1)
- Vascularization (1)
- Veins (1)
- Venous thromboembolism (1)
- Ventricular arrhythmia (1)
- Ventricular arrhythmias (1)
- Venture capital (1)
- Venue Choice (1)
- Verdopplungszeit (1)
- Verfahren der Zeichenprozessierung (1)
- Verfassung (1)
- Verfassungskultur (1)
- Verhalten (1)
- Verkehrsverhalten (1)
- Verlustrücktrag (1)
- Vernakularisierung und Aushandlungsprozesse (1)
- Verstehen (1)
- Vertrauen (1)
- Vespid venom allergy (1)
- Videorasterstereography (1)
- Vietnam (1)
- Vincentius, Pragensis (1)
- Visual analysis (1)
- Visual word recognition (1)
- Vmem (1)
- Vocalization (1)
- Volk (1)
- Vollerhebung (1)
- Volmer–Weber growth (1)
- Volume therapy (1)
- Volumetrie (1)
- Volunteer donor (1)
- Vorsorgeuntersuchung (1)
- Vorstellungen von Lehrkräften (1)
- Voting advice applications (1)
- Voxel-based morphometry (VBM) (1)
- WAF (1)
- WIPO Alert (1)
- WaterGAP (1)
- Watertight Dural closure (1)
- Wealth shocks (1)
- Wearable cardioverter‐defibrillator (1)
- Web (1)
- Weimarer Reichsverfassung (1)
- Well-being (1)
- Werbung (1)
- Werkbegriff (1)
- Werkvernichtung (1)
- Western Kenya (1)
- Western Mediterranean (1)
- Western blot (1)
- Western diet (1)
- Wiederherstellungsansprüche (1)
- Wilhelm von Bode (1)
- Willingness to pay (1)
- Winter survival (1)
- Wirtschaft (1)
- Wissen und Wahrnehmung der Einheimischen (1)
- Wissenschaftsrat (1)
- Wissenschaftstheorie (1)
- Wohnungspolitik (1)
- Wood-Ljungdahl pathway (1)
- Word2vec (1)
- Work and subjectivity (1)
- Work engagement (1)
- Work orientations (1)
- Workplace ergonomics (1)
- World Health Organization (WHO) (1)
- Wound care (1)
- Wound healing (1)
- Wounds (1)
- Wundversorgung (1)
- X-ray crystallography (1)
- XRF analysis (1)
- Xenorhabdus (1)
- X‐ray diffraction (1)
- YM155 (1)
- YWHAE (1)
- YWHAZ (1)
- Year of practical training (1)
- Yeast (1)
- Yellow fluorescent protein (1)
- ZF-L (1)
- Zajonc (1)
- Zentralasien (1)
- Zigarettenalben (1)
- Zigarettenbilder (1)
- Zink (1)
- Ziviler Ungehorsam (1)
- Zivilgesellschaft (1)
- Zolpidem (1)
- Zulu (1)
- [18F]FET PET (1)
- aDGVM (1)
- aDGVM2 (1)
- abduction (1)
- abelian differentials (1)
- abnormality detection (1)
- abuse (1)
- abuso (1)
- academic medicine (1)
- accessibility hierarchy (1)
- acculturation (1)
- acetogen (1)
- acetylation (1)
- acetylcholine (1)
- acetylcholinesterase (1)
- acid dentine lysate (1)
- acidosis (1)
- acoustic emission (1)
- acquired drug resistance (1)
- acquisition of sentence structure (1)
- actin dynamics (1)
- action sounds (1)
- actionism (1)
- activated clotting time measurement (1)
- activities of daily life (1)
- activity-based benefits (1)
- acupuncture (1)
- acute coronary syndromes (1)
- acute decompensation (1)
- acute decompensation of cirrhosis (1)
- acute kidney injury (1)
- acute myeloid leukaemia (1)
- acute respiratory distress syndrome (1)
- acute-on-chronic liver failure (ACLF) (1)
- acute‐on‐chronic liver failure (1)
- adaptive cardiac remodelling (1)
- adaptive immunity (1)
- additive manufacturing (1)
- adenovirus (1)
- adhesion (1)
- adiabatic saturation (1)
- adipose-derived mesenchymal stem/stromal cells (1)
- adjuncts (1)
- adjuvante Krebstherapie (1)
- admixture inference (1)
- adolescentes (1)
- adoptive cancer immunotherapy (1)
- adrenoceptors (1)
- adult and elderly patients (1)
- advanced care planning (1)
- adverse events (1)
- advertising (1)
- aerobic exercise (1)
- aerodynamics (1)
- aesthetic reasons (1)
- aesthetics (1)
- affect (1)
- affective disorder (1)
- affective disorders (1)
- affective flexibility (1)
- affinity purification (1)
- aftercare structures (1)
- agaricomycetes (1)
- age (1)
- age differences (1)
- agency (1)
- agent-based modeling (1)
- aggressiveness (1)
- agriculture (1)
- air flow (1)
- alcohol use disorder (1)
- alcoholic hepatitis (1)
- aldehydes (1)
- aleatoric (1)
- algebraic cluster model (1)
- algorithm (1)
- alirocumab (1)
- alkaloid (1)
- alkylation (1)
- allergy (1)
- allocation (1)
- allogeneic donor (1)
- allogeneic hematopoietic stem cell transplantation (1)
- alpha power (1)
- alpha-galactosidase A deficiency (1)
- alpharetroviral vector (1)
- alpine valley (1)
- alteración por descarga (1)
- alternative Bewertungsformen (1)
- alternative matrices (1)
- alternative oxidase (1)
- alternative performance assessments (1)
- altitude-for-latitude (1)
- ambiguity (1)
- amblyopia (1)
- ames fluctuation assay (1)
- amino acid PET (1)
- amlexanox (1)
- amorphous solid dispersions (1)
- amyloid beta-peptides (1)
- amyotrophic lateral sclerosis (ALS) (1)
- anabelian geometry (1)
- anaemia walk-in clinic (1)
- anaerobic energy metabolism (1)
- anaerobic metabolism (1)
- anal cancer (1)
- anchor (1)
- anemia (1)
- angiography (1)
- angiokeratoma diffuse (1)
- aniline blue (1)
- animacy (1)
- animal (1)
- animal model (1)
- animal personality (1)
- annual bleeding rate (1)
- anomaly (1)
- anthropology (1)
- anti-chronic myeloid leukemia (1)
- anti-diabetes (1)
- anti-immigrant sentiments (1)
- anti-inflammatory agents (1)
- anti-inflammatory drug (1)
- anti-inflammatory effects (1)
- anti-skin aging (1)
- anti-tumor activity (1)
- antibiotic treatment (1)
- antibody tests (1)
- anticoagulation (1)
- anticolonialism (1)
- anticolonialisme (1)
- antifungals (1)
- antigen (1)
- antigen processing and presentation (1)
- antigenic variation (1)
- antigens of infectious origin (1)
- antilocality (1)
- antioxidant defense (1)
- antioxidants (1)
- antireflux surgery (1)
- antiresorptive agents (1)
- antiseizure (1)
- antiviral (1)
- antiviral peptide (1)
- anxiety disorder (1)
- análisis histórico del discurso (1)
- application programming interface (1)
- aprotinin (1)
- aptamers (1)
- arachidonate 12/15-lipoxygenase (Alox12/15) (1)
- archaeology of Fars (1)
- archeological modeling (1)
- argan trees (1)
- argonaute protein (1)
- argumentation (1)
- arithmetic geometry (1)
- arousal (1)
- art criticism (1)
- artesunate (ART) (1)
- artificial intelligence (1)
- artificial ribonuclease (1)
- ascites (1)
- aspect (1)
- aspiration (1)
- aspirin (1)
- assessment of/for learning (1)
- asset pricing (1)
- asset purchases (1)
- assisted reproductive technologies-ARTs (1)
- asthma (1)
- asthma phenotypes (1)
- astrogliosis (1)
- asylum (1)
- asymptomatic (1)
- ataxia telangiectasia (1)
- athletes (1)
- atopy (1)
- attention module (1)
- attention-deficit/hyperactivity disorder (1)
- attentional focus (1)
- attitudes (1)
- attractive crops (1)
- atypical MAPK kinase (1)
- atypical work (1)
- audience (1)
- audience targeting; (1)
- auditory action effects (1)
- auditory fMRI (1)
- auditory prediction (1)
- auditory processing (1)
- autism (1)
- autism spectrum disorder (1)
- autobiographical reasoning (1)
- autobiography (1)
- autograft (1)
- autoimmune diabetes (1)
- autoimmune polyglandular syndrome type 2 (1)
- autoimmune thyroiditis (1)
- autoinhibition (1)
- automatic scoring (1)
- autonomy (1)
- autonomy education (1)
- autoreactivity (1)
- azo compounds (1)
- b-barrel membrane protein (1)
- back pain diagnosis (1)
- background risk (1)
- bacteria (1)
- bacterial microcompartment (1)
- bacterial translocation (1)
- bailout (1)
- balance (1)
- balloon pulmonary angioplasty (1)
- bank capital (1)
- barbell training (1)
- barrel cortex (1)
- barstar (1)
- basal insulin (1)
- baseline (1)
- bed-sharing (1)
- behavioral adverse events (1)
- behavioural syndrome (1)
- benchmark standards (1)
- bereavement (1)
- berotralstat (1)
- beta-diversity turnover (1)
- bicycle use (1)
- biglycan (1)
- bilin-binding photoreceptors (1)
- bio imaging (1)
- bio-enabling formulations (1)
- bioactive lipids (1)
- bioavailability (1)
- biobank (1)
- biocommodities (1)
- biodiversity loss (1)
- bioengineering (1)
- biofuel (1)
- biofuels (1)
- biogeography (1)
- biografia (1)
- biographie (1)
- biography (1)
- biohydrogen (1)
- biological maturation (1)
- biologicals (1)
- bioluminescence (1)
- biomarker study (1)
- biome shifts and transitions (1)
- biomechanics (1)
- biometric risks (1)
- biophysical investigation (1)
- biopolítica (1)
- biopsy naïve (1)
- biotechnology (1)
- biotin (1)
- bio‐enabling formulations (1)
- bipolare Störung (1)
- bladder cancer (BCa) (1)
- bladder exstrophy-epispadias complex (1)
- blinatumomab (1)
- blindness and visual impairment (1)
- blood (1)
- blood flow recovery (1)
- blood flow restriction (1)
- blood loss (1)
- blood pressure (1)
- blood transfusion (1)
- blood-brain barrier (1)
- blood-cerebrospinal fluid barrier (1)
- body dysmorphic disorder (1)
- body plethysmography (1)
- bois d’œuvre (1)
- bone healing (1)
- bone marrow (1)
- bone marrow mononuclear cells (1)
- bone tissue regeneration (1)
- borane (1)
- border control (1)
- boron (1)
- boron heterocycles (1)
- bounded rationality (1)
- brain (1)
- brain anatomy (1)
- brain function (1)
- brain metastases (1)
- brain shift (1)
- brain tumor (1)
- brain-derived neurotrophic factor (1)
- brainstem (1)
- broad-range qPCR (1)
- broadly neutralizing antibodies (1)
- bromeliads (1)
- bronchiolitis obliterans syndrome (1)
- buccal mucosal graft urethroplasty (1)
- bundle (1)
- bunker fuel (1)
- burial (1)
- burnout (1)
- business equity (1)
- butyrylcholinesterase (1)
- bypass (1)
- cART (1)
- cBioPortal (1)
- cHL (1)
- caddisflies (1)
- caesarean scar (1)
- caesarean section (1)
- caged ATP (1)
- caged diacylglycerol (1)
- calcium handling (1)
- calcium-sensor (1)
- calentamiento climático (1)
- cancer associated fibroblasts (1)
- cancer immunobiology (1)
- cancer information (1)
- cancer specific survival (1)
- candidates (1)
- candidemia (1)
- canine cancer (1)
- cannabidiol (1)
- cannabinoids (1)
- cannabis (1)
- canonical divisors (1)
- capital liquidations (1)
- capsaicin (1)
- captive management (1)
- capture processes (1)
- car use reduction (1)
- carbapenem resistance (1)
- carbapenemase (1)
- carbon (1)
- carbon capture (1)
- carbon dioxide reduction (1)
- carbon stocks (1)
- carbonates (1)
- carcinoma (1)
- cardiac (1)
- cardiac I/R injury (1)
- cardiac ischaemia‐reperfusion (1)
- cardiac magnetic (1)
- cardiac rehabilitation (1)
- cardiomyopathy (1)
- cardiothoracic surgery (1)
- care (1)
- career promotion (1)
- cartel damages (1)
- cartilage oligomeric matrix protein (1)
- caste (1)
- catastrophe bond (1)
- catheter (1)
- cell and focal adhesion (1)
- cell death (1)
- cell fractionation (1)
- cell motility (1)
- cell proliferation (1)
- cell survival (1)
- cells (1)
- cellular immunology (1)
- cellular reaction (1)
- cellular therapy (1)
- central bank independence (1)
- central bank information effect (1)
- central nervous system (1)
- central place (1)
- central vowels (1)
- centralisation (1)
- centralni prostor (1)
- ceramides (1)
- cerebellum (1)
- cerumen (1)
- cervical cancer (1)
- cetuximab-bevacizumab therapy sequence (1)
- champ littéraire (1)
- changes immune activation (1)
- chaperone (1)
- chaperones (1)
- charge transfer (1)
- checklist (1)
- chelation therapy (1)
- chemokine receptor 4 (1)
- chemokines (1)
- chemoprotection (1)
- chemotaxis (1)
- chemotherapeutics-treated (1)
- chemotherapy (1)
- chest trauma (1)
- childhood and experience (1)
- children and adolescents (1)
- chlorophyta (1)
- cholestasis (1)
- cholesterol (1)
- cholinesterase (1)
- christians (1)
- chromium (1)
- chromosomal aberrations (1)
- chromosome number (1)
- chronic coronary artery disease (1)
- chronic illness (1)
- chronic inflammation (1)
- chronic kidney disease (1)
- chronic liver disease (1)
- chronic low back pain (1)
- chronic metabolic acidosis (1)
- chronic myeloid leukemia (1)
- chronic thromboembolic pulmonary hypertension (1)
- chronic total occlusion (1)
- chronische Niereninsuffizienz (1)
- chronische metabolische Azidose (1)
- chronotype (1)
- circuit analysis (1)
- circular dichroism (1)
- circulation (1)
- cisplatin resistance (1)
- cisplatin sensitivity (1)
- cities (1)
- citizenship (1)
- civic education (1)
- class separation (1)
- classical Hodgkin lymphoma (1)
- climate warming (1)
- clinical (1)
- clinical benefit (1)
- clinical history (1)
- clinical immunology (1)
- clinical pathways (1)
- clinical study (1)
- clinically important restrictions and symptoms (1)
- cloacal malformation (1)
- clock genes (1)
- clopidogrel (1)
- clustering (1)
- co-crystal (1)
- co-crystallization (1)
- co-sleep (1)
- coaching model (1)
- coaching psychology (1)
- coagulation (1)
- coal (1)
- cochlear implant (1)
- cockroach (1)
- coffee (1)
- cognitive aging (1)
- cognitive conflict (1)
- cognitive decline (1)
- cognitive flexibility (1)
- coherence (1)
- coin hoards (1)
- collaboration (1)
- collagen type I (1)
- collagen-based matrix (1)
- collateral growth (1)
- collective flow (1)
- colon carcinoma (1)
- colorectal cancer (1)
- colorectal cancer (CRC) (1)
- combinatorial biosynthesis (1)
- combined therapy (1)
- commodity (1)
- common genetic variation (1)
- common variants (1)
- communication (1)
- community assembly (1)
- community composition (1)
- comparative oncology (1)
- comparative pathology (1)
- comparison (1)
- competition (1)
- competition fear (1)
- complement; patients (1)
- complex IV (1)
- complex problem-solving (1)
- complicity (1)
- composite structures (1)
- computational biology (1)
- computational chemistry (1)
- computational methods (1)
- computational modeling (1)
- computational neuroimaging (1)
- computational thinking (1)
- computed tomography (1)
- computer vision (1)
- computer-aided diagnosis (1)
- computer-assisted (1)
- conceptual accessibility (1)
- conduct disorder (1)
- confidence (1)
- conflict (1)
- conflict mitigation (1)
- confocal laser scanning microscopy (1)
- conformation analysis (1)
- connaissances et perceptions locales (1)
- connectedness to nature scale (1)
- consequence (1)
- consequences (1)
- conservation (1)
- consolidation treatment (1)
- constituency (1)
- constituency campaigns (1)
- constitution (1)
- consumption-portfolio decisions (1)
- conséquence (1)
- conséquences (1)
- contact heat evoked potentials (CHEPS) (1)
- contamination (1)
- content analysis (1)
- context unit (1)
- continuing education (1)
- continuous vocational education and training (1)
- continuous vocational education training (1)
- contralateral delay activity (1)
- controversy (1)
- coordinated and multiple views (1)
- coping (1)
- copyright (1)
- corona bonds (1)
- corona crisis (1)
- coronary artery bypass surgery (1)
- coronary artery disease (1)
- coronavirus disease 2019 (1)
- corporate governance (1)
- correlated electrons (1)
- correspondence (1)
- cortex (1)
- cortex, gray matter (1)
- cortical folding (1)
- cortisol (1)
- cortisol secretion (1)
- cosmopolitanism (1)
- cost-of-illness (1)
- coupon collector problem (1)
- covalent drugs (1)
- covalent inhibitors (1)
- covalent reversible inhibition (1)
- cox2 (1)
- cranberry (1)
- creativity (1)
- credit funds (1)
- crepitation (1)
- crepitus (1)
- crisis (1)
- critical care (1)
- critical theory (1)
- critical thinking (1)
- cross fitness (1)
- cross-border political access (1)
- cross-frequency coupling (1)
- cross-section of expected stock returns (1)
- cross-section of stock returns (1)
- cross-valley flow (1)
- crosslinguistic influence (1)
- crowdfunding (1)
- crowding (1)
- cryo-EM (1)
- cryo-electron microscopy (1)
- cryo-electron tomography (1)
- cryogenic electron microscopy (1)
- crystal growth (1)
- cultural imperialism (1)
- culture (1)
- cupriavidus necator (1)
- cycle streets (1)
- cyclin Y (1)
- cyclooxygenase 2 (1)
- cyclophosphamide (1)
- cytarabin (1)
- cytochromes (1)
- cytokine gene expression (1)
- cytokine storm (1)
- cytokine-induced killer cells (1)
- cytotoxic lymphocytes (1)
- damage memory (1)
- dapagliflozin (1)
- dark matter (1)
- data (1)
- data acquisition; high energy physics; FPGA; CBM; FLES (1)
- data assimilation (1)
- data production (1)
- data projection (1)
- data structures (1)
- day clinic (1)
- deadwood experiments (1)
- debris (1)
- deception (1)
- decision support systems (1)
- decision-making (1)
- declaration of tobacco ingredients (1)
- declinación rápida de abundancia (1)
- decomposition (1)
- decorin (1)
- deep fascia (1)
- deep learning (1)
- deep mutational scanning (1)
- deep sedation (1)
- deferred treatment (1)
- delayed auditory feedback (1)
- delayed treatment (1)
- deletion mutant (1)
- deliberation (1)
- deliberative democracy (1)
- deliberative systems (1)
- delta oscillations (1)
- demineralized bone matrix (1)
- democratic equality (1)
- democratic legitimacy (1)
- demography (1)
- dendritic cells (1)
- density maps (1)
- density oscillations (1)
- density visualization (1)
- dental assistants (1)
- dental emergency treatment (1)
- dentin adhesives (1)
- dentist (1)
- dentistry (1)
- dentists (1)
- depressive symptoms (1)
- depressive symptoms clusters (1)
- desired affect (1)
- detoxification (1)
- deubiquitinase (DUB) (1)
- deubiquitinating enzyme (1)
- deubiquitylation (deubiquitination) (1)
- developers (1)
- developmental stages (1)
- diabetes (1)
- diabetes therapy (1)
- diagenesis (1)
- diagnosis (1)
- diagnostic algorithm (1)
- diagnostic test (1)
- dialectal variation (1)
- dialectics (1)
- dialectique (1)
- diet (1)
- differential scanning fluorimetry (1)
- differentiation (1)
- diffusion of norms (1)
- diffusion tensor imaging (1)
- digital communications (1)
- digital pathology (1)
- dignity (1)
- dignité (1)
- dihydroceramide (1)
- dimension reduction (1)
- direct objects (1)
- directors (1)
- disability studies (1)
- disadvantaged groups (1)
- discharge alteration (1)
- discrimination (1)
- disease modelling (1)
- disease models (1)
- dislocation (1)
- dispersal (1)
- disproportionate information processing (1)
- dissipation (1)
- distality (1)
- distribution pattern (1)
- diuretics (1)
- diurnal cycle (1)
- diversity (1)
- divorce (1)
- docking domains (1)
- docking studies (1)
- documentary method (1)
- dog study (1)
- domination (1)
- donor safety (1)
- doppelt-hermeneutische Perspektive (1)
- dorsal root ganglia (1)
- double hierarchical model (1)
- doubling time (1)
- drought (1)
- drought index (1)
- drug abstinence (1)
- drug delivery (1)
- drug‐resistant epilepsy (1)
- drug–drug interaction (DDI) (1)
- družbena teorija (1)
- dryland environments (1)
- dual BET/HDAC inhibitor (1)
- dual antiplatelet therapy (1)
- dual focus (1)
- dynamical Higgs effect (1)
- dynamics (1)
- dysbiosis (1)
- dysferlin (1)
- dysferlinopathy (1)
- dysphagia (1)
- e-Health (1)
- e-health (1)
- e-scooter (1)
- eHealth (1)
- ePortfolio (1)
- early detection (1)
- early myocardial damage (EMD) (1)
- early recognition (1)
- early second language acquisition (1)
- early warning signs (1)
- earnings (1)
- eclogite (1)
- ecology of fear (1)
- econometrics (1)
- economic burden (1)
- economic nationalism (1)
- economic sanctions (1)
- economics (1)
- education for sustainable development (ESD) (1)
- educational adequacy (1)
- educational aims (1)
- educational equality (1)
- educational justice (1)
- educational qualification (1)
- educational resources (1)
- effect mechanism (1)
- effectiveness (1)
- efficacy (1)
- effort (1)
- egalitarian liberalism (1)
- eggs-öocytes (1)
- eight disorders (1)
- elderly patients (1)
- electoral systems (1)
- electric scooter (1)
- electricity (1)
- electrochemical CO2 reduction (1)
- electroencephalography (EEG), EEG reference choices, event-related potentials (ERP), independent component analysis (ICA), pain research, contact heat evoked potentials (CHEPS) (1)
- electrolytic cleaning (1)
- electromyostimulation (1)
- electron transport (1)
- electron transport chain (1)
- electronic adherence measurement (1)
- electrophilic fatty acids (1)
- elephant damage (1)
- elephant‐safe stores (1)
- elimination rate constant (1)
- elite athlete (1)
- elites (1)
- embolization (1)
- emergence (1)
- emergency loans (1)
- emergency powers (1)
- emotion regulation (1)
- emotional competency (1)
- emotional exhaustion (1)
- emotionality (1)
- emotions (1)
- empagliflozin (1)
- employees (1)
- employers (1)
- encoding (1)
- encoding/decoding (1)
- end of life care (1)
- endemism (1)
- endocannabinoids (1)
- endolysosomal system (1)
- endometrial cancer (1)
- endothelial cells (1)
- endémisme (1)
- energy (1)
- energy balance (1)
- enfance et expérience (1)
- engagement (1)
- engagement politique (1)
- ensemble simulations (1)
- enterovirus (1)
- entrepreneurship (1)
- environmental behavior (1)
- environmental conditions (1)
- environmental education (1)
- environmental knowledge (1)
- environmental variables (1)
- enzymes (1)
- eph receptor tyrosin kinase family (1)
- ephrins (1)
- epidemics (1)
- epidemiology (1)
- epidermal growth factor receptor (1)
- epididymitis (1)
- epigenetic (1)
- epigenetics (1)
- epileptic encephalopathy (1)
- episodic memory (1)
- epistemic capabilities (1)
- epistemic injustice (1)
- epistemic network analysis (1)
- epithelial cells (1)
- epithelial-to-mesenchymal transition (EMT) (1)
- epithelial‐mesenchymal transition (1)
- epitope mapping (1)
- equality (1)
- equation of state (1)
- equity (1)
- erectile dysfunction (1)
- ergodic subspace analysis (1)
- ergodicity (1)
- ergonomics (1)
- erosion (1)
- erps (1)
- erythropoietin (EPO) (1)
- escape mutations (1)
- essential tremor (1)
- eta meson (1)
- ethnographic knowledge production (1)
- ethnographie (1)
- ethnography (1)
- ethyl pyruvate (1)
- etravirine (1)
- euro area (1)
- euro crisis (1)
- euthymic (1)
- evaluation (1)
- event (1)
- event logs (1)
- event-related potentials (1)
- event-related potentials (ERP) (1)
- everolimus (1)
- evidence-based policy (1)
- ex vivo model (1)
- ex-Gaussian analysis (1)
- exchange rate (1)
- exchange rate response to monetary policy (1)
- excited nuclei (1)
- exercise on prescription (1)
- exercise therapy (1)
- exercise treatment (1)
- exertion (1)
- experiences (1)
- experimental geomorphology (1)
- experimental human pain models (1)
- experimental pain models (1)
- expertise (1)
- exploration (1)
- exports (1)
- exposure (1)
- extensively drug-resistant (1)
- external fixation (1)
- external joint moments (1)
- external memory (1)
- extracellular matrix (1)
- extracellular stimuli (1)
- extraction islands (1)
- extraction socket healing (1)
- extraversion (1)
- extremity (1)
- fMRT (1)
- face inversion effect (1)
- facial nerve functional outcome (1)
- facilitation (1)
- factor VIII (FVIII) (1)
- familial infantile epilepsy (1)
- fasting (1)
- fatigue (1)
- faultlines (1)
- feedback-based flexibility (1)
- feeder cells (1)
- felsic detrital (1)
- felt body (1)
- felt‐bodily communication (1)
- female refugees (1)
- female workers (1)
- feminism (1)
- feminist epistemology (1)
- femoral artery ligation (1)
- fenfluramine (1)
- fermentation (1)
- ferric carboxymaltose (1)
- fibromodulin (1)
- fiduciary (1)
- film curating (1)
- film studies (1)
- financial decision support (1)
- financial disasters (1)
- financial frictions (1)
- financial industry (1)
- financial stablity (1)
- financial sustainability (1)
- financial technology (1)
- finanzielle Armut (1)
- fingolimod (1)
- firm value (1)
- fish bones (1)
- fisheries policy (1)
- fixation (1)
- fixed-links modeling (1)
- flash crashes (1)
- flat surfaces (1)
- flavonoid (1)
- flexible bilingualism (1)
- flow allocation (1)
- fluid reasoning (1)
- fluorescence dye (1)
- focal cortical dysplasia (1)
- focal seizures (1)
- focus movement (1)
- focused electron beam (1)
- for-profit schools (1)
- force transmission (1)
- forensic entomology (1)
- forest management (1)
- form (1)
- forma (1)
- formalin-fixed paraffin-embedded (FFPE) samples (1)
- formate (1)
- formation length (1)
- forms of knowledge (1)
- forward guidance (1)
- fourth (1)
- fractional anisotropy (1)
- fractionation (1)
- fracture (1)
- fragile-X-associated tremor-ataxia syndrome (1)
- fragment-based design (1)
- fragment-based drug design (1)
- fragment-based screening (1)
- fragmentation (1)
- framework transition (1)
- free gingival graft (1)
- free will (1)
- freshwater ecosystems (1)
- fronto-temporal lobar dementia (1)
- fronto-temporal-lobar-dementia (1)
- frühes Zweitspracherwerb (1)
- fully human (1)
- fumonisin B1 (1)
- functional approach to interpretations (1)
- functional connectivity (1)
- functional coupling (1)
- functional genetics (1)
- functional imaging (1)
- fundoplication (1)
- furcation involvement (1)
- further education (1)
- fusion (1)
- game (1)
- game theory (1)
- gamma oscillations (1)
- gap junction protein alpha 4-genotype (1)
- garbage (1)
- gas chromatography-mass spectrometry (1)
- gastric surgery (1)
- gastrocnemius (1)
- gastroesophageal reflux (1)
- gaze-contingent protocol (1)
- geistiges Eigentum (1)
- gender difference (1)
- gender inequality (1)
- gene loss (1)
- gene regulation (1)
- gene therapy (1)
- general equilibrium (1)
- generalized additive model (1)
- generic tasks (1)
- genetic code expansion (1)
- genetic diversity (1)
- genetic generalized epilepsy (1)
- genetic phenotypes (1)
- genetic polymorphisms (1)
- genetic predisposition (1)
- genome-wide association study (1)
- genomics (1)
- geopolitische Rivalität (1)
- geoprostorski statistični podatki (1)
- geospatial data visualization (1)
- geospatial statistics (1)
- geriatric patients (1)
- geriatrischer Ultraschall (1)
- germ cell tumors (1)
- giraffe (1)
- glioblastoma cells (1)
- global (1)
- global care chains (1)
- global democracy (1)
- global educational justice (1)
- global fire modelling (1)
- global real activity (1)
- global water model (1)
- globalism (1)
- globalization (1)
- globalized labor markets (1)
- glucose (1)
- glucose metabolism (1)
- glutaconyl-CoA decarboxylase (1)
- glycoproteins (1)
- glycosaminoglycan (1)
- goals (1)
- governmentality (1)
- gradient (1)
- graft (1)
- grain‐size evolution (1)
- grammar (1)
- grammatical aspect (1)
- grammaticalization (1)
- granular metals (1)
- graph theory (1)
- graph understanding (1)
- gray zone of turbulence (1)
- grey matter volume (1)
- groundwater (1)
- growth inhibition (1)
- guanidine analogs (1)
- guarding behavior (1)
- guideline catalog (1)
- gyrification (1)
- habitat filter (1)
- hadron gas (1)
- haematologic malignancies (1)
- haemophilia A (1)
- haemophilic arthropathy (1)
- haemostasis (1)
- harmine (1)
- hawkes processes (1)
- health (1)
- health care (1)
- health-related quality of life (1)
- healthcare workers (1)
- healthy subjects (1)
- hearing nerve (1)
- heavy-ion collisions (1)
- hemadsorption (1)
- hematoma (1)
- hematopoietic stem and progenitor cells (1)
- heme-regulated inhibitory kinase (1)
- hemiplegic migraine (1)
- hemispherotomy (1)
- hemodynamic (1)
- hemodynamic instability (1)
- hemophilia A (1)
- hemorrhage (1)
- hemorrhagic transformation (1)
- hepatic fibrosis (1)
- hepatic stellate cells (1)
- hepatitis C virus (1)
- hepatitis C virus (HCV) (1)
- hepatitis E (1)
- hepatocellular cancer (1)
- hepatocyte nuclear factor 4α (1)
- herb induced liver injury (1)
- herd immunity (1)
- hereditary angioedema (1)
- hereditary dystopic lipidosis (1)
- herpes simplex virus (1)
- heterologous expression (1)
- heteronuclear detection (1)
- hiPSC (1)
- high dimensional complex data (1)
- high surgical risk (1)
- high-Tc superconductivity (1)
- high-frequency data (1)
- high-frequency traders (HFTs) (1)
- high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (1)
- high-pressure X-ray diffraction (1)
- high-pressure single-crystal X-ray diffraction (1)
- high-throughput nucleotide sequencing (1)
- high-throughput screening (1)
- higher education teachin (1)
- high‐mobility group box‐1 (HMGB1) (1)
- hip joint (1)
- histological outcomes (1)
- histological technic (1)
- histomorphometry (1)
- histone modifications (1)
- histoplasmosis (1)
- historical analysis of discourse (1)
- historical perspectives on sustainability (1)
- history of meteorology (1)
- history of science (1)
- holdout litigation (1)
- home-based (1)
- homeostasis (1)
- homogeneous catalysis (1)
- honey bee classification (1)
- hospitalization (1)
- host-pathogen interaction (1)
- hotochromism (1)
- household finance (1)
- household survey (1)
- household-portfolio shares (1)
- huCAR19 (1)
- human action sounds (1)
- human decellularized dermis (1)
- human footprint (1)
- human genomics (1)
- human lymph node (1)
- human sera (1)
- human values (1)
- human-body radiation (1)
- humanized mice (1)
- humanized mouse model (1)
- human‐wildlife interactions (1)
- human–elephant conflict (1)
- human–environment interaction (1)
- hybrid abutment (1)
- hydrogen oxidation (1)
- hydrogen storage (1)
- hydrogen-dependent carbon dioxide reductase (1)
- hydrology (1)
- hydrothermal fluids (1)
- hydroxamate (1)
- hydroxylation (1)
- hydroxynaphthoquinone (1)
- hyperarousal (1)
- hyperexcitability (1)
- hyperglycemia (1)
- hyperhomocysteinemia (1)
- hyperkalemia (1)
- hyperons (1)
- hypertension (1)
- hypoglycaemia (1)
- hypophosphataemia (1)
- iDILI (1)
- iDrug induced liver injury (1)
- ice coverage (1)
- ideology (1)
- image-based risk modelling (1)
- imageability (1)
- imagery (1)
- images of foreign peoples and places (1)
- imaging (1)
- imbrication (1)
- immersive analytics (1)
- immigration (1)
- immun (1)
- immune checkpoint (1)
- immune checkpoint inhibitors (1)
- immune defense (1)
- immune evasion (1)
- immune response (1)
- immuno-oncotherapy (1)
- immunoprecipitation (1)
- implied volatility (1)
- improvement in quality of life (1)
- in vitro (1)
- in vitro in vivo extrapolation (IVIVE) (1)
- in vitro models (1)
- in vivo model of critical size defects (1)
- incidence (1)
- inclusive physical education (1)
- incomplete design (1)
- independent component analysis (ICA) (1)
- index of lost lifetime (1)
- individual identification (1)
- individual investor (1)
- indoor air pollution (1)
- induced membrane (1)
- induction (1)
- induction chemotherapy (1)
- inertial motion capture (1)
- infant (1)
- infants (1)
- infection dynamics (1)
- infectious diseases (1)
- inferential processes (1)
- inferior frontal gyrus (1)
- infertility (1)
- inflammatory bowel disease (1)
- inflammatory cytokines (1)
- inflammatory markers (1)
- influences of participation in CVET (1)
- informacijska asimetrija (1)
- informal CVET (1)
- information asymmetry (1)
- information landscape (1)
- information structure (1)
- infrared (1)
- infrastructural power (1)
- infância e experiência (1)
- inhibitor design (1)
- inhibitors (1)
- injury (1)
- inklusiver Sportunterricht (1)
- innate and adaptive immune response (1)
- inner ear therapy (1)
- inositol signaling (1)
- insect abundance (1)
- insomnia (1)
- institutional investors (1)
- institutioneller Diskurs (1)
- instructional interventions (1)
- insulator–semiconductor transition (1)
- insulin resistance (1)
- insulitis (1)
- integrated stress response (1)
- intellectual property (1)
- inter-individual variability (1)
- interaction partners (1)
- interactive data analysis (1)
- interactome (1)
- interdisciplinary (1)
- interest in animals (1)
- interferon type III (1)
- intergenerational persistence (1)
- interleukin-6 (1)
- interleukins (1)
- intermediaries (1)
- internal gravity waves (1)
- interoperability (1)
- interpretative authority (1)
- intertextual similarity (1)
- intervertebral disc (IVD) (1)
- interview (1)
- interview study (1)
- intracellular stimuli (1)
- intratextual similarity (1)
- intrinsic drug resistance (1)
- invasion (1)
- invasive mold infection (1)
- inverse dynamics (1)
- investigational (1)
- inflammation (1)
- inflammatory pain (1)
- ion translocation (1)
- ion–atom collisions (1)
- ion–molecule collisions (1)
- iron deficiency (1)
- iron overload versus deprivation (1)
- iron starvation (1)
- iron supplements (1)
- irradiation (1)
- irrigation efficiency (1)
- ischaemia (1)
- island (1)
- islands of divergence (1)
- isohydricity (1)
- isolation (1)
- isospin (1)
- isotope labeling (1)
- isotope tracking model (1)
- item design (1)
- jade axe-head (1)
- jeu (1)
- job non‐routinization (1)
- jobseekers (1)
- joint bleeding (1)
- joint inference (1)
- joint loading (1)
- joint moments (1)
- journalisme (1)
- justification (1)
- juvenile brain lesion (1)
- kaatsu training (1)
- kallikrein inhibitor (1)
- keratinized mucosa (1)
- ketogenic (1)
- ketone body (1)
- kidney formation (1)
- kidney function (1)
- kimberlite (1)
- kinase inhibitors (1)
- kinematics (1)
- kinetic approaches to dense matter (1)
- kinetic fingerprint (1)
- knee adduction moment (1)
- knee joint (1)
- knee noise (1)
- knee sound (1)
- knockout (1)
- knowledge graphs (1)
- kognitive Kompetenz (1)
- kultura žarnih grobišč (1)
- kynureninase (1)
- kynurenine (1)
- labelfree quantitative mass spectrometry (1)
- labeling (1)
- labor supply (1)
- lacosamide (1)
- lactate (1)
- lamotrigine (1)
- land surface temperature (1)
- landscape fragmentation (1)
- land‐use planning (1)
- land–atmosphere coupling (1)
- language acquisition (1)
- language ideologies (1)
- language production (1)
- large eddy simulation (1)
- large functional RNAs (1)
- late Republican civil wars (1)
- latent class analysis (1)
- lateral line (1)
- lattice QCD (1)
- lawsHeavy-ion collisions (1)
- layer-by-layer (LbL) (1)
- lead stannate (Pb2SnO4) (1)
- leaf water potential (1)
- left ventricular non-compaction (1)
- left ventricular trabeculation (1)
- leg alignment (1)
- legal (1)
- legal transplants (1)
- legislative behavior (1)
- legitimation crisis (1)
- lentiviral vector (1)
- letter spacing (1)
- leukocytes (1)
- leukopenia (1)
- leukotriene (1)
- levetiracetam (1)
- lexical aspect (1)
- lexicon (1)
- liability (1)
- liberalism (1)
- liberty (1)
- lichen extracts (1)
- lichen symbiosis (1)
- light microscopy (1)
- light nuclei production (1)
- limb girdle muscular dystrophy type 2B (LGMD2B) (1)
- limited attention (1)
- limits to arbitrage (1)
- linguistic relativity (1)
- lion of the desert movie (1)
- lipid (1)
- lipid raft (1)
- lipidomic analysis (1)
- lipocalin-2 (1)
- lipoxin A4 (1)
- liquid PRF (1)
- liquid chromatography–mass spectrometry (1)
- liquidity (1)
- liquidity provision (1)
- literary field (1)
- literatura seropositiva (1)
- literature education (1)
- lithium (1)
- lithography (1)
- lithospheric mantle (1)
- litter (1)
- liver fibrosis (1)
- liver transplantation (1)
- liver transplantation center (1)
- local inflammation (1)
- lockdown costs (1)
- locked nucleic acids (1)
- locus coeruleus (1)
- log data (1)
- long reads (1)
- long-term observations (1)
- long-term outcome (1)
- long-term potentiation (1)
- long-term prophylaxis (1)
- long-term research (1)
- long-term success (1)
- long-term survival (1)
- longevity (1)
- longitudinal follow-up after epilepsy surgery (1)
- loss function (1)
- loss index (1)
- losses (1)
- low doses (1)
- low-density lipoprotein cholesterol (1)
- low-fee private schools (1)
- low-risk (1)
- lower critical field (1)
- lower extremity arterial disease (1)
- lumbago (1)
- lumbalgia (1)
- lumbar spinal canal stenosis (1)
- lumican (1)
- lump sum (1)
- lung disease phenotype (1)
- lying (1)
- lymphoma (1)
- lysosomes (1)
- mHealth (1)
- mRNA (1)
- mRNA and protein expression (1)
- mRNA surveillance (1)
- macroecology (1)
- macrohabitat (1)
- macromolecular machines (1)
- macrophage polarization (1)
- magentoencephalography (MEG) (1)
- magic angle spinning (1)
- magnesite-II (1)
- magnesium transporters (1)
- magnetic fields (1)
- magnetic nanowires (1)
- magnetic resonance imaging (1)
- magnetic resonance imaging of the brain (1)
- main group elements (1)
- maintenance (1)
- major adverse cardiovascular events (1)
- major depression (MD) (1)
- major depressive disorder (1)
- major depressive disorder (MDD) (1)
- mammary carcinomas (1)
- management (1)
- mandatory reporting (1)
- many-body method (1)
- marginalization (1)
- market making (1)
- market rate of interest (1)
- market supervision (1)
- marxism-leninism (1)
- masculinities (1)
- matching (1)
- materiality (1)
- maternal tobacco smoke (1)
- mathematical modeling (1)
- mathematics (1)
- matrikine (1)
- matrix metalloproteinases (1)
- matroids, online algorithm (1)
- mayflies (1)
- mean diffusivity (1)
- mean response function (1)
- meaning made (1)
- meaning making (1)
- measure (1)
- measurement of situation-specific skills, (1)
- measurement properties (1)
- mechanism of action (1)
- mechanistic oral absorption modeling (1)
- medial shaping (1)
- mediale Durchformung (1)
- mediality (1)
- median response function (1)
- mediation (1)
- medical training (1)
- medicalization (1)
- medication adherence rate (1)
- medicina (1)
- medicine (1)
- melanoma (1)
- melting (1)
- membrane potential (1)
- membrane protein (1)
- membrane proteins (1)
- membrane repair (1)
- memory and learning tests (1)
- mental distress (1)
- mesenchymal stem cell (1)
- mesenchymal stromal/stem cells (1)
- mesopore (1)
- messenger ribonucleoprotein particles (mRNPs) (1)
- meta-analysis (1)
- metabolic reprogramming (1)
- metabolic syndrome (1)
- metabolism (1)
- metabolomics (1)
- metagenome assembly (1)
- metal–organic frameworks (1)
- metaphor (1)
- metasomatism (1)
- meteorological radar (1)
- method of historical hermeneutic (1)
- methodological situationism (1)
- methodology (1)
- methyltransferase (1)
- metodologija (1)
- metáfora (1)
- miR-142-3p (1)
- miR-181 (1)
- miR-6862-5p (1)
- micro CT (1)
- microbial electrosynthesis (1)
- microdialysis (1)
- microlesions (1)
- micromorphology (1)
- micronucleus assay (1)
- microsurgical treatment (1)
- mid-IR spectroscopy (1)
- migrant rights (1)
- migration and invasion (1)
- migration management (1)
- millimeter wave radar (1)
- mineralized tissues (1)
- mini gastric bypass (1)
- minimal clinically important difference (1)
- minimal residual disease (1)
- mir-148a (1)
- missing data (1)
- missing disinflation (1)
- mitochondrial antiviral signaling protein (MAVS) (1)
- mitochondrial dysfunction (1)
- mitochondrial metabolism (1)
- mitochondrial morphology (1)
- mitochondrial respiration (1)
- mixed lineage kinase domain-like (1)
- mobile augmented reality applications (1)
- mobile health (1)
- modal model (1)
- model (1)
- model development (1)
- model psychosis (1)
- modeling and simulation (1)
- modeling of situation-specific skills (1)
- modes of textual presentation (1)
- modi di presentazione testuale (1)
- module test (1)
- moduli spaces (1)
- molecular adaptation (1)
- molecular biology (1)
- molecular politics (1)
- molecular switch (1)
- molecular tumor board (1)
- molecular typing (1)
- monetary institutions (1)
- monetary law (1)
- monetary policy strategy (1)
- monoamine oxidase A (1)
- monocyte chemotactic protein 1 (MCP-1) (1)
- mononuclear cell (1)
- monotype abutment (1)
- monsoon (1)
- morphogenesis (1)
- morphological filtering (1)
- morphometry (1)
- mortality (1)
- mortality analysis (1)
- mortality risk (1)
- mortgages (1)
- motion analysis (1)
- motivations (1)
- motives (1)
- motor control exercise (1)
- mouse (1)
- mouse model (1)
- mouse models (1)
- movement (1)
- movement pattern (1)
- movement profile (1)
- mtDNA haplotypes (1)
- multi-network (1)
- multi-stem architecture (1)
- multi-task learning (1)
- multimodal complex treatment (1)
- multimorbidity (1)
- multiple texts (1)
- multiple trauma (1)
- multipledocument comprehension (1)
- multiscale entropy (1)
- multitarget drugs (1)
- multivariate analyses (1)
- murine model (1)
- muscle (1)
- muscle contraction (1)
- muscle disease (1)
- muscular dystrophy (1)
- musculoskeletal (1)
- musculoskeletal inflammation (1)
- musculoskeletal pain (1)
- musculoskeletal radiographs (1)
- museum (1)
- music neoclassicism (1)
- musical form (1)
- muslims (1)
- mutational antigenic profiling (1)
- mutualist-mediated effects (1)
- myocardial perfusion (1)
- myofascial (1)
- myofascial chains (1)
- myofascial force transmission (1)
- myoferlin (1)
- myotonia congenita (1)
- n,p,π and Λ+Σ0 production (1)
- n400 (1)
- nanobodies (1)
- nanodiscs (1)
- nanofabrication (1)
- nanomagnetism (1)
- narrative content analysis (1)
- narrative economics (1)
- narrative identity (1)
- narrative medicine (1)
- narrative structure (1)
- natives (1)
- natriuretic peptide (1)
- natural beauty (1)
- natural cytotoxicity (1)
- natural killer cell (1)
- natural products (1)
- naturalism (1)
- naturalismo (1)
- naturalistic sample (1)
- nature (1)
- necrosis (1)
- negative Praktiken (1)
- negative practices (1)
- negative-stain electron microscopy (1)
- neglect (1)
- negligencia (1)
- neoliberalism (1)
- neonate (1)
- neonates (1)
- neonatology (1)
- neoplasms (1)
- nerve (1)
- nerve injury (1)
- network effect (1)
- network similarity measurement (1)
- networks (1)
- neurexin (1)
- neurogenesis (1)
- neurological impairment (1)
- neuromodulation (1)
- neuronal maturation (1)
- neuronal morphology (1)
- neuropathic pain (1)
- neuropathy (1)
- neurophysiology (1)
- neuropsychology (1)
- neuroticism (1)
- neurovascular bundle preservation (1)
- neutral mesons (1)
- neutral pion (1)
- neutralization (1)
- neutralizing antibodies (1)
- neutrino-trapping (1)
- neutron microtomography (1)
- neutron star mergers (1)
- neutron stars; (1)
- new phenomenology (1)
- newborn (1)
- newborn screening (1)
- next-generation sequencing (1)
- nitroalkylation (1)
- niños (1)
- nocturnal behavior (1)
- nomos of the earth (1)
- non-bank financial intermediation (1)
- non-canonical amino acid (1)
- non-coding RNAs (1)
- non-compliance (1)
- non-formal CVET (1)
- non-formal music (1)
- non-malignant hematological diseases (1)
- non-natural nucleotide (1)
- non-ribosomal peptide synthetases (1)
- nonbreeding (1)
- noninterventional (1)
- noninvasive blood glucose analysis (1)
- nonlinear dynamical systems (1)
- nonribosomal peptide synthetases (1)
- nonspecific (1)
- non‐selective beta‐blocker (1)
- nostalgia (1)
- nuclear collective model (1)
- nuclear magnetic resonance (NMR) (1)
- nuclear modification (1)
- nuclear receptor (1)
- nucleophilic addition (1)
- nucleophilic boron (1)
- nucleotide analogue (1)
- nucleotide metabolism (1)
- null object stage (1)
- null subjects (1)
- numbers (1)
- nursing (1)
- nutrient endocytosis (1)
- object-scene inconsistency effect (1)
- objects (1)
- observaciones a largo plazo (1)
- observational study (1)
- occupational health (1)
- odločanje (1)
- off-pump surgery (1)
- oil demand elasticity (1)
- oil inventories (1)
- oil supply elasticity (1)
- oligonucleotides (1)
- omega stringer (1)
- oncogenic signaling (1)
- oncological gastrectomy (1)
- oncological outcome (1)
- one anastomosis gastric bypass (1)
- online borrowing (1)
- online information processing (1)
- online nakupovanje (1)
- online purchasing (1)
- online reasoning (1)
- online reasoning patterns (1)
- online survey (1)
- oocyte death (1)
- open content (1)
- open data (1)
- open economy macro-finance modeling (1)
- open guided waves (1)
- open materials (1)
- open science (1)
- operative (1)
- optical coherence tomography (1)
- optimal stopping (1)
- order/disorder (1)
- ordinary language (1)
- ordine/disordine (1)
- organellar ploidy levels (1)
- organizational identification (1)
- orgueil (1)
- orientation (1)
- orthopaedic patients (1)
- oscillations (1)
- oscillators (1)
- osteoarthritis (1)
- osteogenic sarcoma cells (1)
- osteoimmunological changes (1)
- other-report (1)
- otoferlin (1)
- ouabain (1)
- outcomes (1)
- outgroup derogation (1)
- outside-in signaling (1)
- ovary (1)
- overcommitment (1)
- overweight (1)
- own-face perception (1)
- oxidases (1)
- oxidative stress (1)
- oxidised lipids (1)
- p14ARF (1)
- p38 (1)
- p53 (1)
- p53 family (1)
- p63 (1)
- p73 (1)
- pacemaker implantation (1)
- packaging (1)
- packing problem (1)
- pain questionnaire (1)
- pain research (1)
- pain screening (1)
- paleoaltimetry (1)
- paleoanthropology (1)
- paleoclimate (1)
- paleoclimate modeling (1)
- paleoenvironment modeling (1)
- paleoenvironment reconstruction (1)
- pancreatic ductal adenocarcinoma (1)
- pancreatic surgery (1)
- pandemic economics (1)
- pandemic insurance (1)
- pandemics (1)
- pandemics and memory (1)
- parametrization (1)
- parasites Tapinanthus (1)
- parasitism (1)
- parathyroid hormone 2 (1)
- parkinson’s disease (1)
- participation (1)
- participatory education (1)
- partisanship (1)
- passive imaging (1)
- passive immunization (1)
- passive smoke (1)
- passthrough (1)
- patent paradox (1)
- patent system (1)
- patents (1)
- patient centered care (1)
- patient preferences (1)
- patient questionnaire (1)
- patient triage (1)
- patient-reported outcome measure (1)
- patient’s decree (1)
- patient’s perspective (1)
- pauli principle (1)
- paxilline (1)
- peanut allergy (1)
- pedagogical professionalism (1)
- pediatric (1)
- pediatric epilepsy (1)
- pediatric eye screening (1)
- pediatrics (1)
- pelvic packing (1)
- pelvic ring fracture (1)
- peptide antibiotics (1)
- peptide transport (1)
- perception (1)
- perceptual closure (1)
- perceptual priming (1)
- performance assessment (1)
- performance enhancement (1)
- performance tests (1)
- peri-implantitis (1)
- pericytes (1)
- periimplantitis (1)
- perineurium (1)
- periodismo (1)
- periodontal disease progression (1)
- periodontal risk assessment (1)
- periodontal risk calculator (1)
- periodontal risk factors (1)
- perioperative outcome (1)
- perioperative period (1)
- peripheral arterial disease (1)
- peri‐implantitis (1)
- peri‐implantitis therapy (1)
- persistent complex bereavement disorder (1)
- person-oriented approach (1)
- personalised therapy (1)
- personality (1)
- personalization (1)
- pet rabbit (1)
- phage (1)
- phage display (1)
- phage lysis proteins (1)
- phage therapy (1)
- pharmacogenetics (1)
- pharmacokinetics/pharmacodynamics (PK/PD) (1)
- pharmacoresistance (1)
- phase noise (1)
- phase-amplitude coupling (1)
- phenotype/genotype relation (1)
- phenotypic spectrum (1)
- phenylpropanoid (1)
- philosophical style (1)
- phosphate (1)
- phosphorus (1)
- photobleaching (1)
- photoisomerization (1)
- photolabile protecting groups (1)
- photopharmacology (1)
- photopolymerization (1)
- photoschalbare (1)
- photosynthesis (1)
- photosystem maintenance (1)
- photothermal detection (1)
- phylogenetic signal (1)
- phylogeny (1)
- physical activity counseling (1)
- physical training (1)
- physiological coupling (1)
- physiologically based pharmacokinetic (PBPK) modeling (1)
- piezoresistivity (1)
- pigs (1)
- pinning control (1)
- placenta (1)
- planimetric measurement (1)
- planned missing data design (1)
- plant functional traits (1)
- plant life-form (1)
- plant life‐forms (1)
- plant-hydraulics (1)
- plasma (1)
- plasma-derived factor VIII concentrate, prophylaxis (1)
- plasmid (1)
- plasticity (1)
- ploidy (1)
- pluralism (1)
- pneumocystis (1)
- point inversion (1)
- point of care (1)
- policy (1)
- policy intervention (1)
- policy measures in the EU (1)
- policy rules (1)
- political communication in television (1)
- political ecology (1)
- political engagement (1)
- politische Kommunikation im Fernsehen (1)
- politische Ästhetik (1)
- polo-like kinase 1 (1)
- poly(A)-tail (1)
- polyacetylenes (1)
- polyhydroxy (1)
- polyines (1)
- polyketide synthase (1)
- polylactide (1)
- polymorphism (1)
- polyomavirus (1)
- polypharmacology (1)
- polysomnography (1)
- polyynes (1)
- polémica (1)
- population dynamics (1)
- portable fluorimeter (1)
- portfolio (1)
- portosystemic shunt (1)
- positive organizational e-interventions (1)
- positive organizational intervention (1)
- positive organizational interventions (1)
- positivity bias (1)
- positivity preserving property (1)
- post-caesarean uterus (1)
- post-exercise hypotension (1)
- post-liver transplantation management (1)
- post-transcriptional gene regulation (1)
- post-traumatic (1)
- postcolonial studies (1)
- posterior fossa tumor (1)
- posterior risk (1)
- postmonsoon (1)
- postmortem interval (1)
- postoperative complications (1)
- postoperative delirium (1)
- postsecondary education (1)
- posttranslational modification (PTM) (1)
- posttransnational modification (1)
- posttraumatic inflammation (1)
- posttraumatic stress disorder (1)
- postural control (1)
- potassium (1)
- pottery analysis (1)
- power system analysis; (1)
- ppi1 (1)
- practical knowledge of teachers (1)
- practice theory (1)
- pratiques négatives (1)
- praxis (1)
- pre-rationality (1)
- pre-school asthma (1)
- precision weighting (1)
- predation risk (1)
- prediabetes (1)
- predictability (1)
- predictive coding (1)
- prejudice (1)
- prepotent response inhibition (1)
- preregistered (1)
- preschool (1)
- preschool health examination (1)
- presidential debate (1)
- pressure sensors (1)
- pressure-induced phase transition (1)
- preventive medicine (1)
- price discovery (1)
- price stability (1)
- pride (1)
- primary active transporters (1)
- primary biliary cirrhosis (1)
- primary sclerosing cholangitis (1)
- principle of charity (1)
- principles-based regulation (1)
- privacy concerns (1)
- privacy engineering (1)
- privacy-enhancing technologies (1)
- private ordering (1)
- pro-domain (1)
- pro-enzyme (1)
- proanthocyanidin (1)
- problem solving (1)
- procedures of sign processing (1)
- process data (1)
- process mining (1)
- processing (1)
- prodrug (1)
- profession (1)
- professional and organizational development (1)
- profits (1)
- prognostic marker (1)
- prognostic value (1)
- programme sémantique (1)
- proinflammatory microenvironment (1)
- proline isomerization (1)
- prominence (1)
- promotion index (1)
- propanediol utilization (1)
- propensity to patent (1)
- property damage (1)
- prophylactic vaccine (1)
- prophylaxis (1)
- proportionality (1)
- proprotein convertase subtilisin/kexin type 9 inhibition (1)
- prosodic integration (1)
- prosody (1)
- prostate volume (1)
- protease (1)
- protease inhibitor (1)
- protein folding (1)
- protein import (1)
- protein membrane insertion (1)
- protein quality control (1)
- protein structure (1)
- protein turnover (1)
- protein-protein interaction (1)
- proteins (1)
- proteoglycan (1)
- proximal tubule (1)
- prudential supervision (1)
- préjugé (1)
- pseudokinase (1)
- psoriatic arthritis (1)
- psychischer Stress (1)
- psycho-oncology (1)
- psychology (1)
- psychosocial adjustment (1)
- psychotherapy (1)
- public adult education (1)
- public goods (1)
- public health department (1)
- public mental health (1)
- public private partnership (1)
- public sphere (1)
- pull-down (1)
- punctuated equilibrium theory (1)
- pupillometry (1)
- purification of protein complexes (1)
- qRT-PCR (1)
- qRT-PCR detection (1)
- qualitative Inhaltsanalyse (1)
- qualitative content analysis (1)
- quality (1)
- quality control (1)
- quality of care (1)
- quantitative MRT (1)
- quantitative easing (1)
- quantitative methods (1)
- quantitative proteomics (1)
- quantitative sensory testing (1)
- quantum cascade laser (QCL) (1)
- quantum measurement (1)
- quantum mechanics (1)
- quark-gluon plasma (1)
- quintessence (1)
- radar detection (1)
- radar imaging (1)
- radar signal processing (1)
- radar wind profiler (1)
- radiation oncology (1)
- radical prostatectomy (1)
- radioimmunotherapy (1)
- radiomic (1)
- radiosensitization (1)
- radiotherapy (1)
- radon therapy (1)
- rain (1)
- range of motion (1)
- range predictions (1)
- rapid abundance decline (1)
- rare disease (1)
- rare diseases (1)
- rare variants (1)
- rat femur critical size defect (1)
- ratiometric (1)
- ray-tracing (1)
- rct (1)
- re-osseointegration (1)
- re-transplantation (1)
- reaction (1)
- reaction time (1)
- reading comprehension (1)
- readmission rates (1)
- realism (1)
- reality docu (1)
- reasons and barriers (1)
- rebound effect (1)
- receptor cross-interaction (1)
- receptor for advanced glycation end product (RAGE) (1)
- receptor tyrosine kinases (1)
- recombinant vesicular stomatitis virus‐Zaire ebolavirus (1)
- reconciliation (1)
- recruitment (1)
- referee (1)
- reference damage (1)
- reference resolution in production and comprehension (1)
- refined fuels (1)
- reflexivity (1)
- regioisomers (1)
- regulatory T cell (1)
- regulatory T cells (1)
- regulatory T helper cells (1)
- regulatory arbitrage (1)
- regurgitation pellets (1)
- rehabilitation (1)
- reification (1)
- relapsing fever (1)
- relational values (1)
- relationship quality (1)
- relative clause (1)
- relative performance feedback (1)
- relaxometry (1)
- reliable change index (1)
- religion (1)
- religious intellectualism (1)
- remodelling (1)
- remote sensing by radar (1)
- renal cell cancer (1)
- renal transplantation (1)
- renal tubular cells (1)
- renal tubular epithelial cells (1)
- repeat biopsy (1)
- repeated (1)
- reperfusion injury (1)
- repetition suppression (RS) (1)
- repetitive firing (1)
- replication (1)
- replicative fitness (1)
- representaciones (1)
- representation (1)
- representations (1)
- reproduction number (1)
- reproductive isolation (1)
- repsonse process patterns (1)
- request processing (1)
- requirements analysis (1)
- resective surgery (1)
- resident’ knowledge and perceptions (1)
- residual intra‐individual variability (1)
- resiliency (1)
- resistance (1)
- resistance mutation (1)
- resolution (1)
- resolution of inflammation (1)
- resonance (1)
- resonances (1)
- resting EEG (1)
- resting site (1)
- resumptive pronouns (1)
- reticulocyte haemoglobin (1)
- retinal (1)
- retinoid X receptor (1)
- retirement age (1)
- reverse mortgage (1)
- revised universal soil loss equation (1)
- revision (1)
- revisión (1)
- rhabdomyosarcoma (1)
- rheumatoid arthritis (1)
- rhodopsin (1)
- rhythmanalysis (1)
- ribosome-associated quality control (1)
- ridge preservation (1)
- rifiuti (1)
- right heart catheter (1)
- rights (1)
- risk factor (1)
- risk score (1)
- risk sharing (1)
- robo-advice (1)
- rotational thromboelastometry (1)
- ryanodine receptor (1)
- römische Republik (1)
- sCD163 (1)
- sCD206 (1)
- sable water isotopes (1)
- safety (1)
- sage downy mildew (1)
- sarcoma (1)
- sarcopenia (1)
- sarcoplasmic reticulum (1)
- satellite altimetry (1)
- savanna (1)
- scale validation (1)
- scanner noise (1)
- scarto (1)
- scavenger receptor (1)
- scene knowledge (1)
- scene processing (1)
- schiff base (1)
- school closures (1)
- school development (1)
- school leadership, (1)
- schriftliche Haushaltsbefragung (1)
- sciatic nerve (1)
- science studies (1)
- scientific reasoning (1)
- sea-ice meiofauna (1)
- seasonal migration (1)
- seawater influence (1)
- second-best justifications (1)
- second-hand smoke (1)
- secretary problem (1)
- section conjecture (1)
- securities markets (1)
- security management (1)
- sediment budget (1)
- seedling (1)
- seizures (1)
- selection (1)
- selective autophagy receptor (1)
- selective isotopic labeling (1)
- self (1)
- self-tracking (1)
- self‐expanding (1)
- semantic programme (1)
- semantics (1)
- semiexclusive processes (1)
- sensitivity (1)
- sensorimotor (1)
- sensory attenuation (1)
- sensory coding (1)
- sensory neuropathy (1)
- sentence processing (1)
- sequence alignment (1)
- sequence analysis (1)
- sequencing error (1)
- serialism (1)
- serine protease (NS3-4A) (1)
- serology (1)
- serum (1)
- severe acute respiratory syndrome coronavirus (1)
- severe asthma (1)
- severe congenital neutropenia (1)
- severely injured (1)
- severity (1)
- sex (1)
- shadow banking (1)
- shape-shifting representation (1)
- shareholderism (1)
- shipping (1)
- shock filter (1)
- short linear motifs (SLiMs) (1)
- shrinkage (1)
- shrub encroachment (1)
- shrub-tree dynamics (1)
- shrubs (1)
- shunt (1)
- sialitis (1)
- sickle cell anemia (1)
- siderophore (1)
- signal transduction (1)
- signaling (1)
- silent reading (1)
- silica (1)
- silver coinage (1)
- simbólica del mal (1)
- single-molecule förster resonance energy transfer (smFRET) spectroscopy (1)
- single-molecule localization microscopy (1)
- single-particle cryoEM (1)
- single-particle tracking (1)
- site-directed spin labeling (1)
- site-specific labeling (1)
- situation (1)
- skeletal muscle (1)
- slave-making ants (1)
- sleepiness (1)
- smFRET (1)
- small molecule inhibitor (1)
- small protein (1)
- smart home (1)
- smart living (1)
- smart phones (1)
- smarte Ordnungen (1)
- smartphone apps (1)
- smoking in pregnancy (1)
- snoRNAs (1)
- soccer (1)
- social (1)
- social change (1)
- social determinants (1)
- social engineering (1)
- social facilitation (1)
- social identity (1)
- social identity theory (1)
- social inhibition (1)
- social introduction (1)
- social justice (1)
- social justice pedagogy (1)
- social media (1)
- social modelling (1)
- social norms (1)
- social security (1)
- social stratification (1)
- social survey (1)
- social theory (1)
- sociality (1)
- socioeconomic status (1)
- sociology (1)
- soft drinks (1)
- soil bacteria communities (1)
- soil degradation (1)
- soil moisture deficit (1)
- soluble MICA (1)
- solvate (1)
- sonography (1)
- sovereign debt litigation (1)
- sovereign debt restructuring (1)
- sovereign debt standstill (1)
- sovereignty (1)
- sozial-ökologische Transformation (1)
- soziale Exklusion (1)
- soziale Kämpfe (1)
- soziale Netzwerke (1)
- sp2-carbonates (1)
- sp3-carbonates (1)
- sparse imaging (1)
- spatial learning (1)
- spatio-temporal analysis (1)
- spazzatura (1)
- specialized pro-resolving lipid mediators (SPMs) (1)
- speciation (1)
- species inventory (1)
- specific learning disorder (1)
- specificity (1)
- speech act (1)
- speech acts (1)
- sphingosine 1-phoshate (1)
- sphingosine 1-phosphate antagonistst/inhibitors (1)
- sphingosine 1-phosphate metabolism (1)
- sphingosine 1-phosphate signaling (1)
- spin crossover (1)
- spin labeling (1)
- spinal cord (1)
- spintronics (1)
- spiral ganglion cells (1)
- spirochetes (1)
- spirometry (1)
- spliceosome (1)
- spontaneous portosystemic shunt (1)
- sport (1)
- sports (1)
- sports performance (1)
- spreading (1)
- squamous cell carcinoma (1)
- sset pricing (1)
- stabilization (1)
- stage-based models (1)
- stakeholders (1)
- standardization (1)
- standardized regression-based change norms (1)
- starvation (1)
- state (1)
- state of exception (1)
- statische/dynamische Freiheit (1)
- statistical model (1)
- statistical testing (1)
- steady-state condition (1)
- stearic acid (1)
- steatosis (1)
- stem cell transplantation (1)
- stem cells (1)
- steroid control of aging (1)
- stewardship codes (1)
- stiripentol (1)
- stoneflies (1)
- storage (1)
- strain (1)
- strain localization (1)
- strain‐dependent weakening (1)
- strategies (1)
- strategy review (1)
- streamflow deficit (1)
- strength training (1)
- strengths based development (1)
- strengths-based coaching (1)
- streptozotocin (1)
- stress response (1)
- stretching (1)
- stromal-derived factor 1 (1)
- structural VAR (1)
- structural choices (1)
- structural health monitoring (1)
- structural investigation (1)
- structural priming (1)
- structuralism (1)
- structure constraints (1)
- structure narrative (1)
- structure–activity relationships (1)
- strutturalismo (1)
- student movements (1)
- studi scientifici (1)
- subgroups (1)
- subject-only resumption (1)
- subjectivity (1)
- subsistence consumption (1)
- substance abuse disorder (1)
- subtomogram averaging (1)
- subvalent compounds (1)
- succulence (1)
- suicidality (1)
- suicide (1)
- super-resolution microscopy (1)
- superdeterminism (1)
- supervision (1)
- supervisión (1)
- supplementary motor area (1)
- supportive periodontal therapy (1)
- suprapubic catheter (1)
- surface chemistry (1)
- surface-mounted metal–organic frameworks (SURMOFs) (1)
- surfactant (1)
- surgical margin (1)
- surgical procedures (1)
- sustainability transformations (1)
- sustainable development goals (SDGs) (1)
- sustainable travel (1)
- swallowing (1)
- sway analysis (1)
- switching (1)
- symbiosis (1)
- symbolic of evil (1)
- sympathicus (1)
- symptoms (1)
- synaesthesia (1)
- synaptic plasticity (1)
- synaptic scaling (1)
- synaptogenesis (1)
- synchronization (1)
- synergistic interaction (1)
- synovium (1)
- synthetic aperture radar (1)
- synuclein (1)
- system analysis and design (1)
- systematic biopsy (1)
- systematic scoping review (1)
- systemic risk (1)
- tailored treatment schedule (1)
- talent development (1)
- talent identification (1)
- talent management (1)
- tanker (1)
- taphonom (1)
- taphonomy (1)
- targeted biopsy (1)
- targeted therapy (1)
- targeting (1)
- tauopathies (1)
- tauopathy (1)
- taxes (1)
- tea (1)
- teacher training (1)
- teachers' attitudes (1)
- technical (1)
- technique (1)
- technology-based assessment (1)
- telemedicine (1)
- telomerase (1)
- temperature jump (1)
- temporality (1)
- tension type headache (1)
- terahertz (1)
- terapia cognitivo conductual enfocada en trauma (1)
- terrestrial carbon cycle (1)
- terrestrial mammal (1)
- terrestrial water storage (1)
- terrigenous (1)
- test design (1)
- test protocol (1)
- testis (1)
- tetrahydrocannabinol (1)
- tetramerization (1)
- thalassemia (1)
- the Spanish Flu (1)
- the Weddell Sea (1)
- the evolution of religious knowledge (1)
- therapeutic practice (1)
- therapy monitoring (1)
- therapy resistance (1)
- thermophiles (1)
- thermostatic policy change (1)
- thermotolerance (1)
- theta oscillations (1)
- thiazolidine and perhydrothiazine derivatives of aldophosphamide and I-aldophosphamide (1)
- thin films (1)
- third (1)
- threats (1)
- three-dimensional analysis (1)
- three-level topic model (1)
- three‐dimensional analysis (1)
- thrombopenia (1)
- thrombotic microangiopathy (1)
- thrombotic thrombocytopenic purpura (1)
- thylakoid membrane biogenesis (1)
- tick (1)
- timber (1)
- time charter (1)
- time-lapse imaging (1)
- time-resolved spectroscopy (1)
- tissue slice co-cultures (1)
- tissue specificity (1)
- tobacco control (1)
- tobacco products (1)
- toc64 (1)
- tooth (1)
- tooth autotransplantation (1)
- tooth loss (1)
- tooth transplantation (1)
- topological states (1)
- torsion function (1)
- total body score (1)
- total hip replacement (1)
- tracking (1)
- trademark (1)
- trading (1)
- trading behavior (1)
- traditional Chinese medicine (1)
- traffic accident (1)
- trafficking (1)
- training effects (1)
- trait trade-off (1)
- transcatheter aortic valve replacement (TAVR) (1)
- transcatheter aortic valve replacement (TAVR), aortic valve stenosis (AS) (1)
- transcription (1)
- transcriptional activity (1)
- transference of reproductive capacity-TRCs (1)
- transferrin (1)
- transformation (1)
- transformational leadership (1)
- transforming growth factor-β (1)
- transfusion (1)
- transgenically augmented CAR NK cell (1)
- transjugular intrahepatic portosystemic shunt (TIPS) (1)
- transjugular portosystemic intrahepatic (1)
- translanguaging (1)
- translational medical research (1)
- translational medicine (1)
- translational reseach (1)
- translatome (1)
- translocon (1)
- transmission cost allocation (1)
- transmission routes (1)
- transnational education (1)
- transnational populism (1)
- transperspectivism (1)
- transportation (1)
- transrectal prostate biopsy (1)
- transurethral catheter (1)
- transverse axis (1)
- trastorno de duelo prolongado (1)
- trauma (1)
- trauma registry (1)
- traumafocused cognitive behavioural therapy (1)
- traumatic brain injury (1)
- traumatic brain injury (TBI) (1)
- traumatic events (1)
- traumaticbraininjury(TBI) (1)
- travel behavior change (1)
- treatment capacity (1)
- treatment-related changes (1)
- triadic wave–wave interaction (1)
- trigeminal pain (1)
- trophoblast (1)
- tropical Africa (1)
- tropics (1)
- truth (1)
- trypan blue (1)
- tryptophan (1)
- tsetse fly (1)
- tumor adhesion (1)
- tumor angiogenesis (1)
- tumor hypoxia (1)
- tumor infiltrating lymphocytes (1)
- tumor invasion (1)
- tumor migration (1)
- tumor pain (1)
- tumor perfusion (1)
- tumor stroma (1)
- tumor xenograft (1)
- tumor-associated macrophages (1)
- turbulence length scale (1)
- twelve-tone method of composition (1)
- two factor model of environmental values model (1)
- two-pillar system (1)
- type 1 diabetes (1)
- type 2 diabetes (1)
- type-1-diabetes (1)
- types of categories (1)
- tyrosinase inhibitor (1)
- tyrosine kinase inhibitor (1)
- tyrosine kinase inhibitors (1)
- tyrosine kinase inhibitors. (1)
- tyrosine kinase receptor signaling (1)
- ubiquitin chain conformation (1)
- ubiquitin hydrolase (1)
- ubiquitin receptor (1)
- ubiquitination (1)
- ultracold quantum gases (1)
- ultraperipheral and central heavy ion collisions (1)
- ultrasonic cleaning (1)
- ultrasound (1)
- unanticipated (1)
- uncertainties (1)
- uncertainty (1)
- unconfirmed cases (1)
- unconventional T cell (1)
- unconventional superconductor (1)
- under-ice fauna (1)
- understanding (1)
- unilateral hip osteoarthritis (1)
- universalism (1)
- university (1)
- university didactics (1)
- unlautere Geschäftspraktiken (1)
- unspecific low back pain (1)
- urban extent (1)
- urban waste (1)
- urbanicity (1)
- urbanization (1)
- urethral stricture (1)
- urethroplasty (1)
- urinary tract development (1)
- usage (1)
- uterine wall (1)
- utilisations (1)
- vaccination (1)
- vacuuming (1)
- valence (1)
- valley wind (1)
- valproic acid (1)
- value frameworks (1)
- value-added chemicals (1)
- values (1)
- variability (1)
- variable selection (1)
- variable silent delay (1)
- vascular endothelial growth factor receptor (1)
- vascular surgery (1)
- vector (1)
- vegetation modelling (1)
- venous occlusion (1)
- ventralis intermedius nucleus (1)
- venturesomeness (1)
- verb placemen (1)
- vertical transmission (1)
- vestibular schwannoma (1)
- vibroarthrographic (1)
- vigilance (1)
- vincristine (1)
- viral infection (1)
- virtual environments and data visualization (1)
- virtual reality (1)
- viruses (1)
- vision (1)
- visual field loss (1)
- visual priming (1)
- visual processing (1)
- visual programming (1)
- visual search (1)
- vitamin B deficiency (1)
- vitamin B12 (1)
- vitamin D (1)
- vitamin D deficiency (1)
- vitamin D metabolites (1)
- vitamin k antagonists (1)
- vocational education (1)
- volatile sedation (1)
- volatility clustering (1)
- von Willebrand diseases (1)
- voyage (1)
- vulture creditors (1)
- waiting time (1)
- walking (1)
- waste (1)
- water abstraction (1)
- water governance (1)
- water resources management (1)
- water stress (1)
- water temperature (1)
- water use efficiency (1)
- water-saving strategies assessment framework (1)
- wave modulation (1)
- weakly supervised learning (1)
- wealth inequality (1)
- wearables (1)
- web of things (1)
- web-based portfolio (1)
- weight loss (1)
- welfare (1)
- western marxism (1)
- wheezing (1)
- white matter hyperintensity (1)
- whole abdominal radiotherapy (1)
- whole genome sequencing (1)
- whole slide image (1)
- wild boar carcass (1)
- wildfires (1)
- wind (1)
- wind energy (1)
- wind erosion (1)
- wind turbines (1)
- wing geometric morphometrics (1)
- women problem (1)
- wood-inhabiting fungi (1)
- word order in Italian and Greek (1)
- workaholism (1)
- workplace health promotion (1)
- x-ray techniques (1)
- xefoampeptides (1)
- xenograft (1)
- yeast fatty acid synthase (1)
- yellow flags (1)
- young people (1)
- youth football (1)
- youth policy (1)
- youth transition regimes (1)
- zebrafish (1)
- zebrafish development (1)
- zinc finger (1)
- zoo education (1)
- zooplankton (1)
- zymogen (1)
- µ-protein (1)
- Ältere Menschen (1)
- École de Francfort (1)
- ÖPNV (1)
- Öffentlichkeit (1)
- Übertragungswege (1)
- öffentliche Erwachsenenbildung (1)
- öffentlicher Raum (1)
- öffentlicher Verkehr (1)
- ΔNp63 (1)
- α-amylase inhibitor (1)
- α-particles (1)
- β-barrel assembly machinery (BAM) complex (1)
- γ‐H2AX (1)
- η/s (1)
- 失去; 丧亲 (1)
- 延长哀伤障碍 (1)
- 持续性复 杂丧亲障碍 (1)
- fibrogenesis (1)
- field-effect transistor (1)
- fingolimod (1)
- 𝒮-cone (1)
Institute
- Medizin (742)
- Präsidium (278)
- Physik (250)
- Wirtschaftswissenschaften (213)
- Sustainable Architecture for Finance in Europe (SAFE) (167)
- Biowissenschaften (159)
- Frankfurt Institute for Advanced Studies (FIAS) (148)
- Informatik (116)
- Biochemie, Chemie und Pharmazie (104)
- Neuere Philologien (95)
We report an amplitude analysis and branching fraction measurement of D+s→K+K−π+ decay using a data sample of 3.19 fb−1 recorded with BESIII detector at a center-of-mass energy of 4.178 GeV.
We perform a model-independent partial wave analysis in the low K+K− mass region to determine the K+K− S-wave lineshape,
followed by an amplitude analysis of our very pure high-statistics sample.
The amplitude analysis provides an accurate determination of the detection efficiency allowing us to measure the branching fraction B(D+s→K+K−π+)=(5.47±0.08stat±0.13sys)%.
We report an amplitude analysis and branching fraction measurement of D+s→K+K−π+ decay using a data sample of 3.19 fb−1 recorded with BESIII detector at a center-of-mass energy of 4.178 GeV.
We perform a model-independent partial wave analysis in the low K+K− mass region to determine the K+K− S-wave lineshape, followed by an amplitude analysis of our very pure high-statistics sample.
The amplitude analysis provides an accurate determination of the detection efficiency allowing us to measure the branching fraction B(D+s→K+K−π+)=(5.47±0.08stat±0.13sys)%.
We report an amplitude analysis and branching fraction measurement of D+s→K+K−π+ decay using a data sample of 3.19 fb−1 recorded with BESIII detector at a center-of-mass energy of 4.178 GeV.
We perform a model-independent partial wave analysis in the low K+K− mass region to determine the K+K− S-wave lineshape, followed by an amplitude analysis of our very pure high-statistics sample.
The amplitude analysis provides an accurate determination of the detection efficiency allowing us to measure the branching fraction B(D+s→K+K−π+)=(5.47±0.08stat±0.13sys)%.
Using 2.93 fb−1 of 𝑒+𝑒− collision data taken at a center-of-mass energy of 3.773 GeV with the BESIII detector, we report the first measurements of the absolute branching fractions of 14 hadronic 𝐷0(+) decays to exclusive final states with an 𝜂, e.g., 𝐷0→𝐾−𝜋+𝜂, 𝐾0𝑆𝜋0𝜂, 𝐾+𝐾−𝜂, 𝐾0𝑆𝐾0𝑆𝜂, 𝐾−𝜋+𝜋0𝜂, 𝐾0𝑆𝜋+𝜋−𝜂, 𝐾0𝑆𝜋0𝜋0𝜂, and 𝜋+𝜋−𝜋0𝜂; 𝐷+→𝐾0𝑆𝜋+𝜂, 𝐾0𝑆𝐾+𝜂, 𝐾−𝜋+𝜋+𝜂, 𝐾0𝑆𝜋+𝜋0𝜂, 𝜋+𝜋+𝜋−𝜂, and 𝜋+𝜋0𝜋0𝜂. Among these decays, the 𝐷0→𝐾−𝜋+𝜂 and 𝐷+→𝐾0 𝑆𝜋+𝜂 decays have the largest branching fractions, which are ℬ(𝐷0→𝐾−𝜋+𝜂) = (1.853±0.025stat±0.031syst)% and ℬ(𝐷+→𝐾0𝑆𝜋+𝜂) = (1.309±0.037stat±0.031syst)%, respectively. The charge-parity asymmetries for the six decays with highest event yields are determined, and no statistically significant charge-parity violation is found.
There has recently been a dramatic renewal of interest in hadron spectroscopy and charm physics. This renaissance has been driven in part by the discovery of a plethora of charmonium-like XYZ states at BESIII and B factories, and the observation of an intriguing proton-antiproton threshold enhancement and the possibly related X(1835) meson state at BESIII, as well as the threshold measurements of charm mesons and charm baryons.
We present a detailed survey of the important topics in tau-charm physics and hadron physics that can be further explored at BESIII during the remaining operation period of BEPCII. This survey will help in the optimization of the data-taking plan over the coming years, and provides physics motivation for the possible upgrade of BEPCII to higher luminosity.
During the 2016-17 and 2018-19 running periods, the BESIII experiment collected 7.5~fb−1 of e+e− collision data at center-of-mass energies ranging from 4.13 to 4.44~GeV. These data samples are primarily used for the study of excited charmonium and charmoniumlike states. By analyzing the di-muon process e+e−→(γISR/FSR)μ+μ−, we measure the center-of-mass energies of the data samples with a precision of 0.6 MeV. Through a run-by-run study, we find that the center-of-mass energies were stable throughout most of the data-taking period.
Metabolic differences between symbiont subpopulations in the deep-sea tubeworm Riftia pachyptila
(2020)
The hydrothermal vent tube worm Riftia pachyptila lives in intimate symbiosis with intracellular sulfur-oxidizing gammaproteobacteria. Although the symbiont population consists of a single 16S rRNA phylotype, bacteria in the same host animal exhibit a remarkable degree of metabolic diversity: They simultaneously utilize two carbon fixation pathways and various energy sources and electron acceptors. Whether these multiple metabolic routes are employed in the same symbiont cells, or rather in distinct symbiont subpopulations, was unclear. As Riftia symbionts vary considerably in cell size and shape, we enriched individual symbiont cell sizes by density gradient centrifugation in order to test whether symbiont cells of different sizes show different metabolic profiles. Metaproteomic analysis and statistical evaluation using clustering and random forests, supported by microscopy and flow cytometry, strongly suggest that Riftia symbiont cells of different sizes represent metabolically dissimilar stages of a physiological differentiation process: Small symbionts actively divide and may establish cellular symbiont-host interaction, as indicated by highest abundance of the cell division key protein FtsZ and highly abundant chaperones and porins in this initial phase. Large symbionts, on the other hand, apparently do not divide, but still replicate DNA, leading to DNA endoreduplication. Highest abundance of enzymes for CO2 fixation, carbon storage and biosynthesis in large symbionts indicates that in this late differentiation stage the symbiont’s metabolism is efficiently geared towards the production of organic material. We propose that this division of labor between smaller and larger symbionts benefits the productivity of the symbiosis as a whole.
Highlights
• German patients with LGS identified using most specific algorithm to date.
• Prevalence of probable LGS with epilepsy diagnosis before age 6 was 6.5 per 100,000.
• High healthcare costs of €22,787 PPY; mostly due to inpatient and home nursing care.
• Costs were greater in patients prescribed rescue medications.
• Over 10 years, LGS patients had significant mortality vs. controls (2.88 vs. 0.01%).
Abstract
Objective: This retrospective study examined patients with probable Lennox-Gastaut syndrome (LGS) identified from German healthcare data.
Methods: This 10-year study (2007–2016) assessed healthcare insurance claims information from the Vilua Healthcare research database. A selection algorithm considering diagnoses and drug prescriptions identified patients with probable LGS. To increase the sensitivity of the identification algorithm, two populations were defined: all patients with probable LGS (broadly defined) and only those with a documented epilepsy diagnosis before 6 years of age (narrowly defined). This specific criterion was used as LGS typically has a peak seizure onset between age 3 and 5 years. Primary analyses were prevalence and demographics; secondary analyses included healthcare costs, hospitalization rate and length of stay (LOS), medication use, and mortality.
Results: In the final year of the study, 545 patients with broadly defined probable LGS (mean [range] age: 31.4 [2–89] years; male: 53%) were identified. Using the narrowly defined probable LGS definition, the number of patients was reduced to 102 (mean [range] age: 7.4 [2–14] years; male: 52%). Prevalence of broadly defined and narrowly defined probable LGS was 39.2 and 6.5 per 100,000 people. During the 10-year study, 208 patients with narrowly defined probable LGS were identified and followed up for 1379 patient-years. The mean annual cost of healthcare was €22,787 per patient-year (PPY); greatest costs were attributable to inpatient care (33%), home nursing care (13%), and medication (10%). Mean annual healthcare costs were significantly greater for those with prescribed rescue medication (45% of patient-years) versus those without (€33,872 vs. €13,785 PPY, p < 0.001). Mean (standard deviation [SD]) annual hospitalization rate was 1.6 (2.0) PPY with mean (SD) annual LOS of 22.7 (46.0) days. Annual hospitalization rate was significantly greater in those who were prescribed rescue medication versus those who were not (2.2 [2.3] vs. 1.1 [1.6] PPY, p < 0.001). The mean (SD) number of different medications prescribed was 11.3 (7.3) PPY and 33.8 (17.0) over the entire observable time per patient (OET); antiepileptic drugs only accounted for 2.1 (1.1) of the medications prescribed PPY and 3.8 (2.0) OET. Over the 10-year study period, mortality in patients with narrowly defined probable LGS was significantly higher than the matched control population (six events [2.88%] vs. one event [0.01%], p < 0.001).
Conclusion: Annual healthcare costs incurred by patients with probable LGS in Germany were substantial, and mostly attributable to inpatient care, home nursing care, and medication. Patients prescribed with rescue medication incurred significantly greater costs than those who were not. Patients with narrowly defined probable LGS had a higher mortality rate versus control populations.
100 Jahre Dieter Janz
(2020)
The 20 April 2020 marks the centenary of Dieter Janz’s birth. This issue of Zeitschrift für Epileptologie is published in his honor with the aim of tracing the work of Dieter Janz over the last five decades and summarizing new findings on the Janz syndrome (Juvenile Myoclonic Epilepsy), which is named after him.
Protein turnover, the net result of protein synthesis and degradation, enables cells to remodel their proteomes in response to internal and external cues. Previously, we analyzed protein turnover rates in cultured brain cells under basal neuronal activity and found that protein turnover is influenced by subcellular localization, protein function, complex association, cell type of origin, and by the cellular environment (Dörrbaum et al., 2018). Here, we advanced our experimental approach to quantify changes in protein synthesis and degradation, as well as the resulting changes in protein turnover or abundance in rat primary hippocampal cultures during homeostatic scaling. Our data demonstrate that a large fraction of the neuronal proteome shows changes in protein synthesis and/or degradation during homeostatic up- and down-scaling. More than half of the quantified synaptic proteins were regulated, including pre- as well as postsynaptic proteins with diverse molecular functions.
We examined the feedback between the major protein degradation pathway, the ubiquitin-proteasome system (UPS), and protein synthesis in rat and mouse neurons. When protein degradation was inhibited, we observed a coordinate dramatic reduction in nascent protein synthesis in neuronal cell bodies and dendrites. The mechanism for translation inhibition involved the phosphorylation of eIF2α, surprisingly mediated by eIF2α kinase 1, or heme-regulated kinase inhibitor (HRI). Under basal conditions, neuronal expression of HRI is barely detectable. Following proteasome inhibition, HRI protein levels increase owing to stabilization of HRI and enhanced translation, likely via the increased availability of tRNAs for its rare codons. Once expressed, HRI is constitutively active in neurons because endogenous heme levels are so low; HRI activity results in eIF2α phosphorylation and the resulting inhibition of translation. These data demonstrate a novel role for neuronal HRI that senses and responds to compromised function of the proteasome to restore proteostasis.
Keystone mutualisms, such as corals, lichens or mycorrhizae, sustain fundamental ecosystem functions. Range dynamics of these symbioses are, however, inherently difficult to predict because host species may switch between different symbiont partners in different environments, thereby altering the range of the mutualism as a functional unit. Biogeographic models of mutualisms thus have to consider both the ecological amplitudes of various symbiont partners and the abiotic conditions that trigger symbiont replacement. To address this challenge, we here investigate 'symbiont turnover zones'--defined as demarcated regions where symbiont replacement is most likely to occur, as indicated by overlapping abundances of symbiont ecotypes. Mapping the distribution of algal symbionts from two species of lichen-forming fungi along four independent altitudinal gradients, we detected an abrupt and consistent β-diversity turnover suggesting parallel niche partitioning. Modelling contrasting environmental response functions obtained from latitudinal distributions of algal ecotypes consistently predicted a confined altitudinal turnover zone. In all gradients this symbiont turnover zone is characterized by approximately 12°C average annual temperature and approximately 5°C mean temperature of the coldest quarter, marking the transition from Mediterranean to cool temperate bioregions. Integrating the conditions of symbiont turnover into biogeographic models of mutualisms is an important step towards a comprehensive understanding of biodiversity dynamics under ongoing environmental change.
Two-person neuroscience (2 PN) is a recently introduced conceptual and methodological framework used to investigate the neural basis of human social interaction from simultaneous neuroimaging of two or more subjects (hyperscanning). In this study, we adopted a 2 PN approach and a multiple-brain connectivity model to investigate the neural basis of a form of cooperation called joint action. We hypothesized different intra-brain and inter-brain connectivity patterns when comparing the interpersonal properties of joint action with non-interpersonal conditions, with a focus on co-representation, a core ability at the basis of cooperation. 32 subjects were enrolled in dual-EEG recordings during a computerized joint action task including three conditions: one in which the dyad jointly acted to pursue a common goal (joint), one in which each subject interacted with the PC (PC), and one in which each subject performed the task individually (Solo).
A combination of multiple-brain connectivity estimation and specific indices derived from graph theory allowed to compare interpersonal with non-interpersonal conditions in four different frequency bands. Our results indicate that all the indices were modulated by the interaction, and returned a significantly stronger integration of multiple-subject networks in the joint vs. PC and Solo conditions. A subsequent classification analysis showed that features based on multiple-brain indices led to a better discrimination between social and non-social conditions with respect to single-subject indices. Taken together, our results suggest that multiple-brain connectivity can provide a deeper insight into the understanding of the neural basis of cooperation in humans.
Bone vasculature provides protection and signals necessary to control stem cell quiescence and renewal1. Specifically, type H capillaries, which highly express Endomucin, constitute the endothelial niche supporting a microenvironment of osteoprogenitors and long-term hematopoietic stem cells2–4. The age-dependent decline in type H endothelial cells was shown to be associated with bone dysregulation and accumulation of hematopoietic stem cells, which display cell-intrinsic alterations and reduced functionality3. The regulation of bone vasculature by chronic diseases, such as heart failure is unknown. Here, we describe the effects of myocardial infarction and post-infarction heart failure on the vascular bone cell composition. We demonstrate an age-independent loss of type H bone endothelium in heart failure after myocardial infarction in both mice and in humans. Using single-cell RNA sequencing, we delineate the transcriptional heterogeneity of human bone marrow endothelium showing increased expression of inflammatory genes, including IL1B and MYC, in ischemic heart failure. Inhibition of NLRP3-dependent IL-1β production partially prevents the post-myocardial infarction loss of type H vasculature in mice. These results provide a rationale for using anti-inflammatory therapies to prevent or reverse the deterioration of vascular bone function in ischemic heart disease.
We use the quantum null energy condition in strongly coupled two-dimensional field theories (QNEC2) as diagnostic tool to study a variety of phase structures, including crossover, second and first order phase transitions. We find a universal QNEC2 constraint for first order phase transitions with kinked entanglement entropy and discuss in general the relation between the QNEC2-inequality and monotonicity of the Casini-Huerta c-function. We then focus on a specific example, the holographic dual of which is modelled by three-dimensional Einstein gravity plus a massive scalar field with one free parameter in the self-interaction potential. We study translation invariant stationary states dual to domain walls and black branes. Depending on the value of the free parameter we find crossover, second and first order phase transitions between such states, and the c-function either flows to zero or to a finite value in the infrared. Strikingly, evaluating QNEC2 for ground state solutions allows to predict the existence of phase transitions at finite temperature.
We use the quantum null energy condition in strongly coupled two-dimensional field theories (QNEC2) as diagnostic tool to study a variety of phase structures, including crossover, second and first order phase transitions. We find a universal QNEC2 constraint for first order phase transitions with kinked entanglement entropy and discuss in general the relation between the QNEC2-inequality and monotonicity of the Casini-Huerta c-function. We then focus on a specific example, the holographic dual of which is modelled by three-dimensional Einstein gravity plus a massive scalar field with one free parameter in the self-interaction potential. We study translation invariant stationary states dual to domain walls and black branes. Depending on the value of the free parameter we find crossover, second and first order phase transitions between such states, and the c-function either flows to zero or to a finite value in the infrared. Strikingly, evaluating QNEC2 for ground state solutions allows to predict the existence of phase transitions at finite temperature.
We use holography to study the dynamics of a strongly-coupled gauge theory in four-dimensional de Sitter space with Hubble rate H. The gauge theory is non-conformal with a characteristic mass scale M. We solve Einstein’s equations numerically and determine the time evolution of homogeneous gauge theory states. If their initial energy density is high compared with H4 then the early-time evolution is well described by viscous hydrodynamics with a non-zero bulk viscosity. At late times the dynamics is always far from equilibrium. The asymptotic late-time state preserves the full de Sitter symmetry group and its dual geometry is a domain-wall in AdS5. The approach to this state is characterised by an emergent relation of the form P = w E that is different from the equilibrium equation of state in flat space. The constant w does not depend on the initial conditions but only on H/M and is negative if the ratio H/M is close to unity. The event and the apparent horizons of the late-time solution do not coincide with one another, reflecting its non-equilibrium nature. In between them lies an “entanglement horizon” that cannot be penetrated by extremal surfaces anchored at the boundary, which we use to compute the entanglement entropy of boundary regions. If the entangling region equals the observable universe then the extremal surface coincides with a bulk cosmological horizon that just touches the event horizon, while for larger regions the extremal surface probes behind the event horizon.
Background: Data on the arrhythmic burden of women at risk for sudden cardiac death are limited, especially in patients using the wearable cardioverter-defibrillator (WCD).
Objective: We aimed to characterize WCD compliance, atrial and ventricular arrhythmic burden, and WCD outcomes by sex in patients enrolled in the Prospective Registry of Patients Using the Wearable Cardioverter Defibrillator (WEARIT-II U.S. Registry).
Methods: In the WEARIT-II Registry, we stratified 2000 patients by sex into women (n = 598) and men (n = 1402). WCD wear time, ventricular and atrial arrhythmic events during WCD use, and implantable cardioverter-defibrillator (ICD) implantation rates at the end of WCD use were evaluated.
Results: The mean WCD wear time was similar in women and men (94 days vs 90 days; P = .145), with longer daily use in women (21.4 h/d vs 20.7 h/d; P = .001). Burden of ventricular tachycardia or ventricular fibrillation was higher in women, with 30 events per 100 patient-years compared with 18 events per 100 patient-years in men (P = .017), with similar findings for treated and non-treated ventricular tachycardia/ventricular fibrillation. Recurrent atrial arrhythmias/sustained ventricular tachycardia was also more frequent in women than in men (167 events per 100 patient-years vs 73 events per 100 patient-years; P = .042). However, ICD implantation rate at the end of WCD use was similar in both women and men (41% vs 39%; P = .448).
Conclusion: In the WEARIT-II Registry, we have shown a higher burden of ventricular and atrial arrhythmic events in women than in men. ICD implantation rates at the end of WCD use were similar. Our findings warrant monitoring women at risk for sudden cardiac death who have a high burden of atrial and ventricular arrhythmias while using the WCD.
Highlights
• Transparency of design, reference frames and support for action were found to support students' sense-making of LA dashboards.
• The higher the overall SRL score, the more relevant the three factors were perceived by learners.
• Learner goals affect how relevant students find reference frames.
• The SRL effect on the perceived relevance of transparency depends on learner goals.
Abstract
Unequal stakeholder engagement is a common pitfall of adoption approaches of learning analytics in higher education leading to lower buy-in and flawed tools that fail to meet the needs of their target groups. With each design decision, we make assumptions on how learners will make sense of the visualisations, but we know very little about how students make sense of dashboard and which aspects influence their sense-making. We investigated how learner goals and self-regulated learning (SRL) skills influence dashboard sense-making following a mixed-methods research methodology: a qualitative pre-study followed-up with an extensive quantitative study with 247 university students. We uncovered three latent variables for sense-making: transparency of design, reference frames and support for action. SRL skills are predictors for how relevant students find these constructs. Learner goals have a significant effect only on the perceived relevance of reference frames. Knowing which factors influence students' sense-making will lead to more inclusive and flexible designs that will cater to the needs of both novice and expert learners.
Ziel dieser Untersuchung ist es, die Legitimität der Kriminalisierung des Glücksspiels in Brasilien zu hinterfragen. Dies geschieht mit besonderem Augenmerk auf das spezifische brasilianische Glücksspiel, das „Spiel der Tiere“ (Jogo do bicho), das Ende des 19. Jahrhunderts in der Stadt Rio de Janeiro, der Hauptstadt des damaligen kaiserlichen Brasiliens, entstand. Es handelt sich um eine Form des Glücksspiels, die sich in ganz Brasilien verbreitet hat und bereits Gegenstand mehrerer akademischer Studien in den Bereichen Anthropologie und Soziologie war. Das Verbot dieser Art von Glücksspiel, seine Kriminalisierung, seine große Beliebtheit und seine gesellschaftliche Toleranz sind jedoch Gründe dafür, dass das Spiel der Tiere im Besonderen und das Glücksspiel im Allgemeinen auch im juristischen Bereich, insbesondere im Strafrecht, ein bisher vernachlässigter Forschungsgegenstand von großem Interesse ist.
Das Hauptaugenmerk dieser Arbeit liegt auf der Analyse der Kriminalisierung des Glücksspiels, das in Brasilien seit über einem Jahrhundert unter freiem Himmel praktiziert wird. Bei dieser Analyse werden die Gründe für die Kriminalisierung und die Legitimität des Verbots in Frage gestellt. Zu diesem Zweck ist der Text, abgesehen von der Einleitung und der Schlussfolgerung, in sechs Kapitel unterteilt.
Kapitel 1 beschreibt die Geschichte des brasilianischen Tierspiels, die Ursprünge seines Verbots und seiner Kriminalisierung. In Kapitel 2 wird über die Wirklichkeit der Strafverfolgung in diesem „Kriminalitätsbereich“ berichtet. Kapitel 3 stellt den ent-sprechenden Straftatbestand des brasilianischen „Código Penal“ im Kontext der Systematik des brasilianischen Strafgesetzbuches vor. Kapitel 4 widmet sich zunächst den verfassungsrechtlichen Grenzen der Kriminalisierung, und danach einem Überblick über das deutsche Glücksspielverbot und die Glücksspielregulierung. Ergänzt wird diese Suche in Kapitel 5, in dem die Forschung das strafrechtliche Glücksspielverbot in den Kontext der Debatte über die Abgrenzung zwischen und den Zusammenhang von Recht und Moral. Im abschließenden Kapitel 6 wird das (strafrechtlich sanktionierte) Glücksspielverbot mit den klassischen Legitimations-anforderungen konfrontiert.
Was in der strafrechtlichen Literatur der ersten Hälfte des 20. Jahrhunderts zur Rechtfertigung des Verbots zu lesen ist, deutet auf einen großen Einfluss moralischer Argumente hin. Diese Argumente haben bis heute an Gewicht nicht verloren, auch wenn die Befürworter der Beibehaltung der Kriminalisierung versuchen, ihre letztlich moralistische Ideologie gegen das Glücksspiel mit Argumenten wie der Begleitkriminalität des Glückspiels zu verschleiern, die eher eine Folge als eine Ursache der Kriminalisierung ist.
Decline in physical activity in the weeks preceding sustained ventricular arrhythmia in women
(2020)
Background: Heightened risk of cardiac arrest following physical exertion has been reported. Among patients with an implantable defibrillator, an appropriate shock for sustained ventricular arrhythmia was preceded by a retrospective self-report of engaging in mild-to-moderate physical activity. Previous studies evaluating the relationship between activity and sudden cardiac arrest lacked an objective measure of physical activity and women were often underrepresented.
Objective: To determine the relationship between physical activity, recorded by accelerometer in a wearable cardioverter-defibrillator (WCD), and sustained ventricular arrhythmia among female patients.
Methods: A dataset of female adult patients prescribed a WCD for a diagnosis of myocardial infarction or dilated cardiomyopathy was compiled from a commercial database. Curve estimation, to include linear and nonlinear interpolation, was applied to physical activity as a function of time (days before arrhythmia).
Results: Among women who received an appropriate WCD shock for sustained ventricular arrhythmia (N = 120), a quadratic relationship between time and activity was present prior to shock. Physical activity increased starting at the beginning of the 30-day period up until day -16 (16 days before the ventricular arrhythmia) when activity begins to decline.
Conclusion: For patients who received treatment for sustained ventricular arrhythmia, a decline in physical activity was found during the 2 weeks preceding the arrhythmic event. Device monitoring for a sustained decline in physical activity may be useful to identify patients at near-term risk of a cardiac arrest.
Das Staatsangehörigkeitsrecht verankert rechtlich Vorstellungen über Zugehörigkeit und bestimmt wer vollumfängliche Rechte in einer Gesellschaft hat und wer nicht. Jahrzehntelang wurde Migration in Deutschland als etwas temporäres betrachtet. Im Staatsangehörigkeitsrecht galt bis zur Reform 1999/2000 weitgehend das „ius sanguinis“, das Abstammungsrecht, das auf einem rassistischen und völkischen Staatsverständnis beruht. Diese Reform bedeutete somit mehr als eine reine Gesetzesänderung. Sie war eine Anerkennung Deutschlands als Einwanderungsland und die Veränderung der Vorstellung deutscher Identität. Als Reaktion entbrannte infolge der Reformpläne eine hitzige, rassistische Debatte in der Öffentlichkeit über ebendiese Fragen, die unter dem polarisierten Schlagwort „Doppelpass“ verhandelt wurde. Es war die lauteste migrationspolitische Debatte dieser Zeit.
Kurze Zeit vor Beginn dieser Debatte war die rechtsterroristische Gruppe „Nationalsozialistischer Untergrund“ (NSU) abgetaucht, um einem Haftbefehl zu entgehen. Der NSU war ein deutsches, neonazistisches Netzwerk, in dessen Mittelpunkt drei Terrorist*innen standen. Sie verübten über einen Zeitraum von zwölf Jahren eine rassistische Mordserie an neun Personen türkischer, kurdischer und griechischer Herkunft sowie drei Sprengstoffanschläge auf migrantische Orte und ermordeten eine Polizistin. Den ersten ihrer Sprengstoffanschläge begingen sie nur einen Monat nach der Unterzeichnung der Reform. Wenige Monate nach dem Inkrafttreten des Gesetzes begannen sie mit dem Anschlag auf Enver Şimşek ihre rassistische Mordserie.
Diese Arbeit untersucht anhand der Struktur der Historisch-Materialistischen Politikanalyse das Migrationsregime um die Staatsangehörigkeitsreform von 1999/2000 und wie der NSU darin verortet werden kann.
Die Kontextanalyse stellt auf der Grundlage einer Literaturrecherche die relevanten historischen und strukturellen Faktoren der Debatte sowie des NSU dar. Im nächsten Schritt werden mithilfe einer Analyse von Zeitungsartikel aus dieser Zeit die relevanten Akteur*innen identifiziert und in die vier Hegemonieprojekte neoliberal, sozial, linksliberal-alternativ und konservativ gruppiert. Darauffolgend wird der Ablauf der Debatte in vier Phasen darstellt und als Aushandlung der vier Hegemonieprojekte rekonstruiert. Dabei zeigt sich, dass kein Projekt sich vollumfänglich durchsetzen und Hegemonie erreichen konnte, sie jedoch unterschiedlich stark in den Medien repräsentiert wurden.
Im letzten Schritt betrachtet diese Arbeit Verbindungen dieser Migrationsregime-Analyse zum NSU. Sie kommt zu dem Ergebnis, dass der NSU kein Akteur im Migrationsregime um die Staatsangehörigkeitsdebatte von 1998/99 war. Aufgrund der geringen Erkenntnisse über spezifische Meinungen des NSU zum Staatsangehörigkeitsrecht, können keine kausalen Beziehungen hergestellt werden. Dennoch zeigt diese Arbeit Gemeinsamkeiten in den Weltbildern, Annahmen und migrationspolitischen Zielen des NSU, des konservativen Hegemonieprojektes sowie Teilen der Bevölkerung auf. Dadurch wird ein Beitrag dazu geleistet den NSU als Produkt und Teil der deutschen Gesellschaft zu begreifen.
Attention-Deficit/Hyperactivity Disorder (ADHD) and obesity are frequently comorbid, genetically correlated, and share brain substrates. The biological mechanisms driving this association are unclear, but candidate systems, like dopaminergic neurotransmission and circadian rhythm, have been suggested. Our aim was to identify the biological mechanisms underpinning the genetic link between ADHD and obesity measures and investigate associations of overlapping genes with brain volumes. We tested the association of dopaminergic and circadian rhythm gene sets with ADHD, body mass index (BMI), and obesity (using GWAS data of N = 53,293, N = 681,275, and N = 98,697, respectively). We then conducted genome-wide ADHD–BMI and ADHD–obesity gene-based meta-analyses, followed by pathway enrichment analyses. Finally, we tested the association of ADHD–BMI overlapping genes with brain volumes (primary GWAS data N = 10,720–10,928; replication data N = 9428). The dopaminergic gene set was associated with both ADHD (P = 5.81 × 10−3) and BMI (P = 1.63 × 10−5); the circadian rhythm was associated with BMI (P = 1.28 × 10−3). The genome-wide approach also implicated the dopaminergic system, as the Dopamine-DARPP32 Feedback in cAMP Signaling pathway was enriched in both ADHD–BMI and ADHD–obesity results. The ADHD–BMI overlapping genes were associated with putamen volume (P = 7.7 × 10−3; replication data P = 3.9 × 10−2)—a brain region with volumetric reductions in ADHD and BMI and linked to inhibitory control. Our findings suggest that dopaminergic neurotransmission, partially through DARPP-32-dependent signaling and involving the putamen, is a key player underlying the genetic overlap between ADHD and obesity measures. Uncovering shared etiological factors underlying the frequently observed ADHD–obesity comorbidity may have important implications in terms of prevention and/or efficient treatment of these conditions.
Inhibitors against the NS3-4A protease of hepatitis C virus (HCV) have proven to be useful drugs in the treatment of HCV infection. Although variants have been identified with mutations that confer resistance to these inhibitors, the mutations do not restore replicative fitness and no secondary mutations that rescue fitness have been found. To gain insight into the molecular mechanisms underlying the lack of fitness compensation, we screened known resistance mutations in infectious HCV cell culture with different genomic backgrounds. We observed that the Q41R mutation of NS3-4A efficiently rescues the replicative fitness in cell culture for virus variants containing mutations at NS3-Asp168. To understand how the Q41R mutation rescues activity, we performed protease activity assays complemented by molecular dynamics simulations, which showed that protease-peptide interactions far outside the targeted peptide cleavage sites mediate substrate recognition by NS3-4A and support protease cleavage kinetics. These interactions shed new light on the mechanisms by which NS3-4A cleaves its substrates, viral polyproteins and a prime cellular antiviral adaptor protein, the mitochondrial antiviral signaling protein MAVS. Peptide binding is mediated by an extended hydrogen-bond network in NS3-4A that was effectively optimized for protease-MAVS binding in Asp168 variants with rescued replicative fitness from NS3-Q41R. In the protease harboring NS3-Q41R, the N-terminal cleavage products of MAVS retained high affinity to the active site, rendering the protease susceptible for potential product inhibition. Our findings reveal delicately balanced protease-peptide interactions in viral replication and immune escape that likely restrict the protease adaptive capability and narrow the virus evolutionary space.
Cryo-electron tomography combined with subtomogram averaging (StA) has yielded high-resolution structures of macromolecules in their native context. However, high-resolution StA is not commonplace due to beam-induced sample drift, images with poor signal-to-noise ratios (SNR), challenges in CTF correction, and limited particle number. Here we address these issues by collecting tilt series with a higher electron dose at the zero-degree tilt. Particles of interest are then located within reconstructed tomograms, processed by conventional StA, and then re-extracted from the high-dose images in 2D. Single particle analysis tools are then applied to refine the 2D particle alignment and generate a reconstruction. Use of our hybrid StA (hStA) workflow improved the resolution for tobacco mosaic virus from 7.2 to 4.4 Å and for the ion channel RyR1 in crowded native membranes from 12.9 to 9.1 Å. These resolution gains make hStA a promising approach for other StA projects aimed at achieving subnanometer resolution.
Cryo electron tomography (cryo-ET) combined with subtomogram averaging (StA) enables structural determination of macromolecules in their native context. A few structures were reported by StA at resolution higher than 4.5 Å, however all of these are from viral structural proteins or vesicle coats. Reaching high resolution for a broader range of samples is uncommon due to beam-induced sample drift, poor signal-to-noise ratio (SNR) of images, challenges in CTF correction, limited number of particles. Here we propose a strategy to address these issues, which consists of a tomographic data collection scheme and a processing workflow. Tilt series are collected with higher electron dose at zero-degree tilt in order to increase SNR. Next, after performing StA conventionally, we extract 2D projections of the particles of interest from the higher SNR images and use the single particle analysis tools to refine the particle alignment and generate a reconstruction. We benchmarked our proposed hybrid StA (hStA) workflow and improved the resolution for tobacco mosaic virus from 7.2 to 5.2 Å and the resolution for the ion channel RyR1 in crowded native membranes from 12.9 to 9.1 Å. We demonstrate that hStA can improve the resolution obtained by conventional StA and promises to be a useful tool for StA projects aiming at subnanometer resolution or higher.
Relationship between regional white matter hyperintensities and alpha oscillations in older adults
(2020)
Objective: To investigate whether regional white matter hyperintensities (WMHs) relate to alpha oscillations (AO) in a large population-based sample of elderly individuals.
Methods: We associated voxel-wise WMHs from high-resolution 3-Tesla MRI with neuronal alpha oscillations (AO) from resting-state multichannel EEG at sensor (N=907) and source space (N=855) in older participants of the LIFE-Adult study (60–80 years). In EEG, we computed relative alpha power (AP), individual alpha peak frequency (IAPF), as well as long-range temporal correlations (LRTC) that represent dynamic properties of the signal. We implemented whole-brain voxel-wise regression models to identify regions where parameters of AO were linked to probability of WMH occurrence. We further used mediation analyses to examine whether WMH volume mediated the relationship between age and AO.
Results: Higher prevalence of WMHs in the superior and posterior corona radiata was related to elevated relative AP, with strongest correlations in the bilateral occipital cortex, even after controlling for potential confounding factors. The age-related increase of relative AP in the right temporal brain region was shown to be mediated by total WMH volume.
Conclusion: A high relative AP corresponding to increased regional WMHs was not associated with age per se, in fact, this relationship was mediated by WMHs. We argue that the WMH-associated increase of AP reflects a generalized and likely compensatory spread of AO leading to a larger number of synchronously recruited neurons. Our findings thus suggest that longitudinal EEG recordings might be sensitive to detect functional changes due to WMHs.
Relationship between regional white matter hyperintensities and alpha oscillations in older adults
(2020)
White matter hyperintensities (WMHs) in the cerebral white matter and attenuation of alpha oscillations (AO; 7–13 Hz) occur with the advancing age. However, a crucial question remains, whether changes in AO relate to aging per se or they rather reflect the impact of age-related neuropathology like WMHs. In this study, using a large cohort (N=907) of elderly participants (60-80 years), we assessed relative alpha power (AP), individual alpha peak frequency (IAPF) and long-range temporal correlations (LRTC) from resting-state EEG. We further associated these parameters with voxel-wise WMHs from 3T MRI. We found that higher prevalence of WMHs in the superior and posterior corona radiata was related to elevated relative AP, with strongest correlations in the bilateral occipital cortex, even after controlling for potential confounding factors. In contrast, we observed no significant relation of probability of WMH occurrence with IAPF and LRTC. We argue that the WMH-associated increase of AP reflects generalized and likely compensatory changes of AO leading to a larger number of synchronously recruited neurons.
Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis
(2020)
Highlights
• Hypoxia decreases NCOA4 transcription in primary human macrophages.
• NCOA4 mRNA is a target of miR-6862-5p.
• Lowering NCOA4 increases FTMT abundance under hypoxia.
• FTMT and FTH protect from ferroptosis.
• Tumor cells lack the hypoxic decrease of NCOA4 and fail to stabilize FTMT.
Abstract
Cellular iron, at the physiological level, is essential to maintain several metabolic pathways, while an excess of free iron may cause oxidative damage and/or provoke cell death. Consequently, iron homeostasis has to be tightly controlled. Under hypoxia these regulatory mechanisms for human macrophages are not well understood. Hypoxic primary human macrophages reduced intracellular free iron and increased ferritin expression, including mitochondrial ferritin (FTMT), to store iron. In parallel, nuclear receptor coactivator 4 (NCOA4), a master regulator of ferritinophagy, decreased and was proven to directly regulate FTMT expression. Reduced NCOA4 expression resulted from a lower rate of hypoxic NCOA4 transcription combined with a micro RNA 6862-5p-dependent degradation of NCOA4 mRNA, the latter being regulated by c-jun N-terminal kinase (JNK). Pharmacological inhibition of JNK under hypoxia increased NCOA4 and prevented FTMT induction. FTMT and ferritin heavy chain (FTH) cooperated to protect macrophages from RSL-3-induced ferroptosis under hypoxia as this form of cell death is linked to iron metabolism. In contrast, in HT1080 fibrosarcome cells, which are sensitive to ferroptosis, NCOA4 and FTMT are not regulated. Our study helps to understand mechanisms of hypoxic FTMT regulation and to link ferritinophagy and macrophage sensitivity to ferroptosis.
The tremendous diversity of life in the ocean has proven to be a rich source of inspiration for drug discovery, with success rates for marine natural products up to 4 times higher than other naturally derived compounds. Yet the marine biodiscovery pipeline is characterized by chronic underfunding, bottlenecks and, ultimately, untapped potential. For instance, a lack of taxonomic capacity means that, on average, 20 years pass between the discovery of new organisms and the formal publication of scientific names, a prerequisite to proceed with detecting and isolating promising bioactive metabolites. The need for “edge” research that can spur novel lines of discovery and lengthy high-risk drug discovery processes, are poorly matched with research grant cycles. Here we propose five concrete pathways to broaden the biodiscovery pipeline and open the social and economic potential of the ocean genome for global benefit: (1) investing in fundamental research, even when the links to industry are not immediately apparent; (2) cultivating equitable collaborations between academia and industry that share both risks and benefits for these foundational research stages; (3) providing new opportunities for early-career researchers and under-represented groups to engage in high-risk research without risking their careers; (4) sharing data with global networks; and (5) protecting genetic diversity at its source through strong conservation efforts. The treasures of the ocean have provided fundamental breakthroughs in human health and still remain under-utilised for human benefit, yet that potential may be lost if we allow the biodiscovery pipeline to become blocked in a search for quick-fix solutions.
Macro-finance theory predicts that financial fragility builds up when volatility is low. This “volatility paradox’” challenges traditional systemic risk measures. I explore a new dimension of systemic risk, spillover persistence, which is the average time horizon at which a firm’s losses increase future risk in the financial system. Using firm-level data covering more than 30 years and 50 countries, I document that persistence declines when fragility builds up: before crises, during stock market booms, and when banks take more risks. In contrast, persistence increases with loss amplification: during crises and fire sales. These findings support key predictions of recent macrofinance models.
Understanding effects of emotional valence and stress on children’s memory is important for educational and legal contexts. This study disentangles the effects of emotional content of to-be-remembered information (i.e., items differing in emotional valence and arousal), stress exposure, and associated cortisol secretion on children’s memory. We also examine whether girls’ memory is more affected by stress induction. 143 6-to-7-year-old children were randomly allocated to the Trier Social Stress Test for Children (n = 103) or a control condition (n = 40). 25 minutes after stressor onset, children incidentally encoded 75 objects varying in emotional valence (crossed with arousal) together with neutral scene backgrounds. We found that response-bias corrected memory was worse for low arousing negative items than neutral and positive items, with the latter two categories not being different from each other. Whilst boys’ memory was largely unaffected by stress, girls in the stress condition showed worse memory for negative items, especially the low arousing ones, than girls in the control condition. Girls, compared to boys, reported higher subjective stress increases following stress exposure, and had higher cortisol stress responses. Whilst a higher cortisol stress response was associated with better emotional memory in girls in the stress condition, boys’ memory was not associated with their cortisol secretion. Taken together, our study suggests that 6-to-7-year-old children, more so girls, show memory suppression for negative information. Girls’ memory for negative information, compared to boys, is also more strongly modulated by stress experience and the associated cortisol response.
Aims: Acetylsalicylic acid (ASA) is widely used for the prevention of atherothrombotic events in patients with chronic coronary artery disease (CAD) and peripheral artery disease (PAD), but the risk of vascular events remains high. We aimed at identifying randomised controlled trials (RCTs) on antithrombotic treatments in patients with chronic CAD or PAD.
Methods: Searches were conducted on MEDLINE, EMBASE, and CENTRAL on March 1st, 2018. This systematic review (SR) uses a narrative synthesis to summarize the evidence for the efficacy and safety of antiplatelet and anticoagulant therapies in the population of both chronic CAD or PAD patients.
Results: Four RCTs from 27 publications were included. Study groups included 15,603 to 27,395 patients. ASA alone was the most extensively studied (n = 3); other studies included rivaroxaban with or without ASA (n = 1), vorapaxar alone (n = 1), and clopidogrel with (n = 1) or without ASA (n = 1). Clopidogrel alone and clopidogrel plus ASA compared to ASA presented similar efficacy with comparable safety profile. Rivaroxaban plus ASA significantly reduced the risk of the composite of cardiovascular death, myocardial infarction, and stroke compared to ASA alone, although major bleeding with rivaroxaban plus ASA increased.
Conclusion: There is limited and heterogeneous evidence on the prevention of atherothrombotic events in patients with chronic CAD or PAD. Clopidogrel alone and clopidogrel plus ASA did not demonstrate superiority over ASA alone. A combination of rivaroxaban plus ASA may offer significant additional benefit in reducing cardiovascular outcomes, yet it may increase the risk of bleeding, compared to ASA alone.
Determination of a minimal postmortem interval via age estimation of necrophagous diptera has been restricted to the juvenile stages and the time until emergence of the adult fly, i.e. up until 2–6 weeks depending on species and temperature. Age estimation of adult flies could extend this period by adding the age of the fly to the time needed for complete development. In this context pteridines are promising metabolites, as they accumulate in the eyes of flies with increasing age. We studied adults of the blow fly Lucilia sericata at constant temperatures of 16 °C and 25 °C up to an age of 25 days and estimated their pteridine levels by fluorescence spectroscopy. Age was given in accumulated degree days (ADD) across temperatures. Additionally, a mock case was set up to test the applicability of the method. Pteridine increases logarithmically with increasing ADD, but after 70–80 ADD the increase slows down and the curve approaches a maximum. Sex had a significant impact (p < 4.09 × 10−6) on pteridine fluorescence level, while body-size and head-width did not. The mock case demonstrated that a slight overestimation of the real age (in ADD) only occurred in two out of 30 samples. Age determination of L. sericata on the basis of pteridine levels seems to be limited to an age of about 70 ADD, but depending on the ambient temperature this could cover an extra amount of time of about 5–7 days after completion of the metamorphosis.
Cabozantinib (Cabometyx®) is a potent multikinase inhibitor targeting the vascular endothelial growth factor (VEGF) receptor 2, the mesenchymal-epithelial transition factor (MET) receptor, and the “anexelekto” (AXL) receptor tyrosine kinase. It is approved for the treatment of advanced hepatocellular carcinoma (HCC) after failure of sorafenib in Europe (since November 2018) and in the USA (since January 2019). The approval of cabozantinib was based on results of the randomized, placebo-controlled, phase 3 CELESTIAL trial in patients with unresectable HCC, who received one or two prior lines of treatment including sorafenib. At the second planned interim analysis, the trial was stopped, because the primary end point overall survival was clearly in favor for cabozantinib. Additionally, median progression-free survival was superior to placebo. The most common ≥ grade 3 relevant adverse events in patients with HCC treated with cabozantinib were palmar–plantar erythrodysesthesia, hypertension, fatigue, and diarrhea. In this review, current data on cabozantinib for the treatment of patients with advanced HCC, with a focus on the management of common adverse events and ongoing clinical trials, are discussed.
External linkages allow nascent ventures to access crucial resources during the process of new product development. Forming external linkages can substantially contribute to a venture’s performance. However, little is known about the paths of external linkage formation, as well as the circumstances that drive the choice to pursue one rather than another path. This gap deserves further investigation, because we do not know whether insights developed for incumbent firms also apply to nascent ventures: To address this gap, we explore a novel dataset of 370 venture creation processes. Using sequence analyses based on optimal matching techniques and cluster analyses, we reveal that nascent ventures pursue one of overall four distinct paths of linkage formation activities during new product development. Contrary to the findings of the strategy literature, we find that if nascent ventures engage in external linkages at all, they do not combine exploration- and exploitation-oriented linkages but form either exploration- or exploitation-oriented linkages. Additional regression analyses highlight the circumstances that lead nascent ventures to pursue one rather than the other pathways. Taken together, our analyses point out that resource scarcity constitutes an important factor shaping the linkage formation activities of nascent ventures. Accordingly, we show that nascent ventures tend not to optimize by adding complementary knowledge to the firm’s knowledge base but rather to extend the existing knowledge base—a strategy which we call bricolage.
In recent decades, the assessment of instructional quality has grown into a popular and well-funded arm of educational research. The present study contributes to this field by exploring first impressions of untrained raters as an innovative approach of assessment. We apply the thin slice procedure to obtain ratings of instructional quality along the dimensions of cognitive activation, classroom management, and constructive support based on only 30 s of classroom observations. Ratings were compared to the longitudinal data of students taught in the videos to investigate the connections between the brief glimpses into instructional quality and student learning. In addition, we included samples of raters with different backgrounds (university students, middle school students and educational research experts) to understand the differences in thin slice ratings with respect to their predictive power regarding student learning. Results suggest that each group provides reliable ratings, as measured by a high degree of agreement between raters, as well predictive ratings with respect to students’ learning. Furthermore, we find experts’ and middle school students’ ratings of classroom management and constructive support, respectively, explain unique components of variance in student test scores. This incremental validity can be explained with the amount of implicit knowledge (experts) and an attunement to assess specific cues that is attributable to an emotional involvement (students).
Die Gattungen Nicotiana tabacum und Nicotiana rustica der Tabakpflanze sind von großer wirtschaftlicher Bedeutung. Aus ihnen wird Tabak hergestellt, der mit Alkohol zur weltweit am häufigsten konsumierten Genussdroge zählt. Aufgrund seiner Legalität wird die Toxizität trotz steigender Warnung und Aufklärung immer noch unterschätzt. Die Toxizität der Tabakpflanze ist vor allem auf das Alkaloid Nikotin zurückzuführen. Dass es selten zu einer Vergiftung durch die reine Pflanze kommt, liegt daran, dass sie optisch kaum zum Verzehr anregt. Häufiger dagegen ist eine Vergiftung durch z. B. verschluckte Zigarettenstummel, die vor allem für Kinder sehr gefährlich sein kann. Eine weitere Gefahr der Vergiftung entsteht bei der Tabakernte. Nikotin wird auch über die Haut aufgenommen und kann so zu der Green Tobacco Sickness bei Tabakplantagenarbeitern führen. Im Ernstfall existiert kein Antidot. Aktivkohle sollte so schnell wie möglich gegeben werden, um die Resorption zu vermindern. Ansonsten muss das Nikotin mit einer Magenwäsche aus dem Körper gefiltert werden. Präventiv sollten deshalb verstärkt auf die Gefahren des Tabaks aufmerksam gemacht werden.
The metasomatised continental mantle may play a key role in the generation of some ore deposits, in particular mineral systems enriched in platinum-group elements (PGE) and Au. The cratonic lithosphere is the longest-lived potential source for these elements, but the processes that facilitate their pre-concentration in the mantle and their later remobilisation to the crust are not yet well-established. Here, we report new results on the petrography, major-element, and siderophile- and chalcophile-element composition of native Ni, base metal sulphides (BMS), and spinels in a suite of well-characterised, highly metasomatised and weakly serpentinised peridotite xenoliths from the Bultfontein kimberlite in the Kaapvaal Craton, and integrate these data with published analyses. Pentlandite in polymict breccias (failed kimberlite intrusions at mantle depth) has lower trace-element contents (e.g., median total PGE 0.72 ppm) than pentlandite in phlogopite peridotites and Mica-Amphibole-Rutile-Ilmenite-Diopside (MARID) rocks (median 1.6 ppm). Spinel is an insignificant host for all elements except Zn, and BMS and native Ni account for typically <25% of the bulk-rock PGE and Au. High bulk-rock Te/S suggest a role for PGE-bearing tellurides, which, along with other compounds of metasomatic origin, may host the missing As, Ag, Cd, Sb, Te and, in part, Bi that are unaccounted for by the main assemblage.
The close spatial relationship between BMS and metasomatic minerals (e.g., phlogopite, ilmenite) indicates that the lithospheric mantle beneath Bultfontein was resulphidised by metasomatism after initial melt depletion during stabilisation of the cratonic lithosphere. Newly-formed BMS are markedly PGE-poor, as total PGE contents are <4.2 ppm in pentlandite from seven samples, compared to >26 ppm in BMS in other peridotite xenoliths from the Kaapvaal craton. This represents a strong dilution of the original PGE abundances at the mineral scale, perhaps starting from precursor PGE alloy and small volumes of residual BMS. The latter may have been the precursor to native Ni, which occurs in an unusual Ni-enriched zone in a harzburgite and displays strongly variable, but overall high PGE abundances (up to 81 ppm). In strongly metasomatised peridotites, Au is enriched relative to Pd, and was probably added along with S. A combination of net introduction of S, Au +/− PGE from the asthenosphere and intra-lithospheric redistribution, in part sourced from subducted materials, during metasomatic events may have led to sulphide precipitation at ~80–120 km beneath Bultfontein. This process locally enhanced the metallogenic fertility of this lithospheric reservoir. Further mobilisation of the metal budget stored in these S-rich domains and upwards transport into the crust may require interaction with sulphide-undersaturated melts that can dissolve sulphides along with the metals they store.
Objectives: Lumbar spinal stenosis (LSS) and lumbar disc herniation (LDH) are often accompanied by frequently occurring leg cramps severely affecting patients’ life and sleep quality. Recent evidence suggests that neuromuscular electric stimulation (NMES) of cramp-prone muscles may prevent cramps in lumbar disorders.
Materials and Methods: Thirty-two men and women (63 ± 9 years) with LSS and/or LDH suffering from cramps were randomly allocated to four different groups. Unilateral stimulation of the gastrocnemius was applied twice a week over four weeks (3 × 6 × 5 sec stimulation trains at 30 Hz above the individual cramp threshold frequency [CTF]). Three groups received either 85%, 55%, or 25% of their maximum tolerated stimulation intensity, whereas one group only received pseudo-stimulation.
Results: The number of reported leg cramps decreased in the 25% (25 ± 14 to 7 ± 4; p = 0.002), 55% (24 ± 10 to 10 ± 11; p = 0.014) and 85%NMES (23 ± 17 to 1 ± 1; p < 0.001) group, whereas it remained unchanged after pseudo-stimulation (20 ± 32 to 19 ± 33; p > 0.999). In the 25% and 85%NMES group, this improvement was accompanied by an increased CTF (p < 0.001).
Conclusion: Regularly applied NMES of the calf muscles reduces leg cramps in patients with LSS/LDH even at low stimulation intensity.
We show explicit formulas for the evaluation of (possibly higher-order) fractional Laplacians (-△)ˢ of some functions supported on ellipsoids. In particular, we derive the explicit expression of the torsion function and give examples of s-harmonic functions. As an application, we infer that the weak maximum principle fails in eccentric ellipsoids for s ∈ (1; √3 + 3/2) in any dimension n ≥ 2. We build a counterexample in terms of the torsion function times a polynomial of degree 2. Using point inversion transformations, it follows that a variety of bounded and unbounded domains do not satisfy positivity preserving properties either and we give some examples.
Highlights
• PUR, PVC and PLA microplastics affect life-history parameters of Daphnia magna.
• Natural kaolin particles are less toxic than microplastics.
• Microplastic toxicity is material-specific, e.g. PVC is most toxic on reproduction.
• In case of PVC, plastic chemicals are the main driver of microplastic toxicity.
• PLA bioplastics are similarly toxic as conventional plastics.
Abstract
Given the ubiquitous presence of microplastics in aquatic environments, an evaluation of their toxicity is essential. Microplastics are a heterogeneous set of materials that differ not only in particle properties, like size and shape, but also in chemical composition, including polymers, additives and side products. Thus far, it remains unknown whether the plastic chemicals or the particle itself are the driving factor for microplastic toxicity. To address this question, we exposed Daphnia magna for 21 days to irregular polyvinyl chloride (PVC), polyurethane (PUR) and polylactic acid (PLA) microplastics as well as to natural kaolin particles in high concentrations (10, 50, 100, 500 mg/L, ≤ 59 μm) and different exposure scenarios, including microplastics and microplastics without extractable chemicals as well as the extracted and migrating chemicals alone. All three microplastic types negatively affected the life-history of D. magna. However, this toxicity depended on the endpoint and the material. While PVC had the largest effect on reproduction, PLA reduced survival most effectively. The latter indicates that bio-based and biodegradable plastics can be as toxic as their conventional counterparts. The natural particle kaolin was less toxic than microplastics when comparing numerical concentrations. Importantly, the contribution of plastic chemicals to the toxicity was also plastic type-specific. While we can attribute effects of PVC to the chemicals used in the material, effects of PUR and PLA plastics were induced by the mere particle. Our study demonstrates that plastic chemicals can drive microplastic toxicity. This highlights the importance of considering the individual chemical composition of plastics when assessing their environmental risks. Our results suggest that less studied polymer types, like PVC and PUR, as well as bioplastics are of particular toxicological relevance and should get a higher priority in ecotoxicological studies.
Deubiquitinases (DUBs) are vital for the regulation of ubiquitin signals, and both catalytic activity of and target recruitment by DUBs need to be tightly controlled. Here, we identify asparagine hydroxylation as a novel posttranslational modification involved in the regulation of Cezanne (also known as OTU domain–containing protein 7B (OTUD7B)), a DUB that controls key cellular functions and signaling pathways. We demonstrate that Cezanne is a substrate for factor inhibiting HIF1 (FIH1)- and oxygen-dependent asparagine hydroxylation. We found that FIH1 modifies Asn35 within the uncharacterized N-terminal ubiquitin-associated (UBA)-like domain of Cezanne (UBACez), which lacks conserved UBA domain properties. We show that UBACez binds Lys11-, Lys48-, Lys63-, and Met1-linked ubiquitin chains in vitro, establishing UBACez as a functional ubiquitin-binding domain. Our findings also reveal that the interaction of UBACez with ubiquitin is mediated via a noncanonical surface and that hydroxylation of Asn35 inhibits ubiquitin binding. Recently, it has been suggested that Cezanne recruitment to specific target proteins depends on UBACez. Our results indicate that UBACez can indeed fulfill this role as regulatory domain by binding various ubiquitin chain types. They also uncover that this interaction with ubiquitin, and thus with modified substrates, can be modulated by oxygen-dependent asparagine hydroxylation, suggesting that Cezanne is regulated by oxygen levels.
In diesem Beitrag werden Spezifika der mit der qualitativen Inhaltsanalyse vorgenommenen Leserezeptionsforschung dargestellt. Der Schwerpunkt liegt auf dem literarischen Lesen. In Analysen von Textrezeptionszeugnissen, die zu literaturdidaktischen Forschungszwecken vorgenommen werden, ergibt sich eine doppelt-hermeneutische Herausforderung: Ziel ist es zu verstehen, was Leser_innen in Texten verstehen. Für den Analyseprozess folgen daraus spezifische Anforderungen: Erstens muss der Umfang der Kontexteinheit geklärt werden. Hier sind differenzierte Antworten notwendig, weil sich der gegebene Kontext im Leseprozess ständig verändert. Zweitens erfordert das Forschungsinteresse eine bestimmte Art von Kategorien, die in der Literatur als formal bzw. analytisch bezeichnet werden. Eine weitere Differenzierung zwischen strikt formalen und theoriebasiert formalen Kategorien wird hier vorgeschlagen. Drittens muss geklärt werden, ob die rekonstruierten Leseaktivitäten Prozesse sind, oder ob sie auf zugrunde liegende Dispositionen schließen lassen. Diese Anforderungen werden diskutiert und mit Lösungsansätzen versehen.
Highlights
• Explanation of mobility design and its practical, aesthetic and emblematic effects on travel behaviour.
• Review of recent studies on mobility design elements and the promotion of non-motorised travel.
• Discussion of research gaps and methodological challenges of data collection and comparability.
Abstract
To promote non-motorised travel, many travel behaviour studies acknowledge the importance of the built environment to modal choice, for example with its density or mix of uses. From a mobility design theory perspective, however, objects and environments affect human perceptions, assessments and behaviour in at least three different ways: by their practical, aesthetic and emblematic functions. This review of existing evidence will argue that travel behaviour research has so far mainly focused on the practical function of the built environment. For that purpose, we systematically identified 56 relevant studies on the impacts of the built environment on non-motorised travel behaviour in the Web of Science database. The focus of research on the practical design function primary involves land use distribution, street network connectivity and the presence of walking and cycling facilities. Only a small number of papers address the aesthetic and emblematic functions. These show that the perceived attractiveness of an environment and evoked feelings of traffic safety increase the likelihood of walking and cycling. However, from a mobility design perspective, the results of the review indicate a gap regarding comprehensive research on the effects of the aesthetic and emblematic functions of the built environment. Further research involving these functions might contribute to a better understanding of how to promote non-motorised travel more effectively. Moreover, limitations related to survey techniques, regional distribution and the comparability of results were identified.
Assessment of individual therapeutic responses provides valuable information concerning treatment benefits in individual patients. We evaluated individual therapeutic responses as determined by the Disease Activity Score-28 joints critical difference for improvement (DAS28-dcrit) in rheumatoid arthritis (RA) patients treated with intravenous tocilizumab or comparator anti-tumor necrosis factor (TNF) agents. The previously published DAS28-dcrit value [DAS28 decrease (improvement) ≥ 1.8] was retrospectively applied to data from two studies of tocilizumab in RA, the 52-week ACT-iON observational study and the 24-week ADACTA randomized study. Data were compared within (not between) studies. DAS28 was calculated with erythrocyte sedimentation rate as the inflammatory marker. Stability of DAS28-dcrit responses and European League Against Rheumatism (EULAR) good responses was determined by evaluating repeated responses at subsequent timepoints. A logistic regression model was used to calculate p values for differences in response rates between active agents. Patient-reported outcomes (PROs; pain, global health, function, and fatigue) in DAS28-dcrit responder versus non-responder groups were compared with an ANCOVA model. DAS28-dcrit individual response rates were 78.2% in tocilizumab-treated patients and 58.2% in anti-TNF-treated patients at week 52 in the ACT-ion study (p = 0.0001) and 90.1% versus 59.1% at week 24 in the ADACTA study (p < 0.0001). DAS28-dcrit responses showed greater stability over time (up to 52 weeks) than EULAR good responses. For both active treatments, DAS28-dcrit responses were associated with statistically significant improvements in mean PRO values compared with non-responders. The DAS28-dcrit response criterion provides robust assessments of individual responses to RA therapy and may be useful for discriminating between active agents in clinical studies and guiding treat-to-target decisions in daily practice.
Methoden
(2020)
Rezension zu: Akremi, Leila, Nina Baur, Hubert Knoblauch und Boris Traue (Hrsg.): Handbuch Interpretativ forschen. Weinheim, Basel: Beltz Juventa 2018. 961 Seiten. ISBN: 978-3-7799-3126-3. Preis: C 49,95.
Human RNF213, which encodes the protein mysterin, is a known susceptibility gene for moyamoya disease (MMD), a cerebrovascular condition with occlusive lesions and compensatory angiogenesis. Mysterin mutations, together with exposure to environmental trigger factors, lead to an elevated stroke risk since childhood. Mysterin is induced during cell stress, to function as cytosolic AAA+ ATPase and ubiquitylation enzyme. Little knowledge exists, in which context mysterin is needed. Here, we found that genetic ablation of several mitochondrial matrix factors, such as the peptidase ClpP, the transcription factor Tfam, as well as the peptidase and AAA+ ATPase Lonp1, potently induces Rnf213 transcript expression in various organs, in parallel with other components of the innate immune system. Mostly in mouse fibroblasts and human endothelial cells, the Rnf213 levels showed prominent upregulation upon Poly(I:C)-triggered TLR3-mediated responses to dsRNA toxicity, as well as upon interferon gamma treatment. Only partial suppression of Rnf213 induction was achieved by C16 as an antagonist of PKR (dsRNA-dependent protein kinase). Since dysfunctional mitochondria were recently reported to release immune-stimulatory dsRNA into the cytosol, our results suggest that mysterin becomes relevant when mitochondrial dysfunction or infections have triggered RNA-dependent inflammation. Thus, MMD has similarities with vasculopathies that involve altered nucleotide processing, such as Aicardi-Goutières syndrome or systemic lupus erythematosus. Furthermore, in MMD, the low penetrance of RNF213 mutations might be modified by dysfunctions in mitochondria or the TLR3 pathway.
Purpose: Neonatal surgery for abdominal wall defects is not performed in a centralized manner in Germany. The aim of this study was to investigate whether treatment for abdominal wall defects in Germany is equally effective compared to international results despite the decentralized care.
Methods: All newborn patients who were clients of the major statutory health insurance company in Germany between 2009 and 2013 and who had a diagnosis of gastroschisis or omphalocele were included. Mortality during the first year of life was analysed.
Results: The 316 patients with gastroschisis were classified as simple (82%) or complex (18%) cases. The main associated anomalies in the 197 patients with omphalocele were trisomy 18/21 (8%), cardiac anomalies (32%) and anomalies of the urinary tract (10%). Overall mortality was 4% for gastroschisis and 16% for omphalocele. Significant factors for non-survival were birth weight below 1500 g for both groups, complex gastroschisis, volvulus and anomalies of the blood supply to the intestine in gastroschisis, and female gender, trisomy 18/21 and lung hypoplasia in omphalocele.
Conclusions: Despite the fact that paediatric surgical care is organized in a decentralized manner in Germany, the mortality rates for gastroschisis and omphalocele are equal to those reported in international data.
A convex body is unconditional if it is symmetric with respect to reflections in all coordinate hyperplanes. We investigate unconditional lattice polytopes with respect to geometric, combinatorial, and algebraic properties. In particular, we characterize unconditional reflexive polytopes in terms of perfect graphs. As a prime example, we study the signed Birkhoff polytope. Moreover, we derive constructions for Gale-dual pairs of polytopes and we explicitly describe Gröbner bases for unconditional reflexive polytopes coming from partially ordered sets.
Purpose of Review: To provide an overview of current surgical peri-implantitis treatment options.
Recent Findings: Surgical procedures for peri-implantitis treatment include two main approaches: non-augmentative and augmentative therapy. Open flap debridement (OFD) and resective treatment are non-augmentative techniques that are indicated in the presence of horizontal bone loss in aesthetically nondemanding areas. Implantoplasty performed adjunctively at supracrestally and buccally exposed rough implant surfaces has been shown to efficiently attenuate soft tissue inflammation compared to control sites. However, this was followed by more pronounced soft tissue recession. Adjunctive augmentative measures are recommended at peri-implantitis sites exhibiting intrabony defects with a minimum depth of 3 mm and in the presence of keratinized mucosa. In more advanced cases with combined defect configurations, a combination of augmentative therapy and implantoplasty at exposed rough implant surfaces beyond the bony envelope is feasible.
Summary: For the time being, no particular surgical protocol or material can be considered as superior in terms of long-term peri-implant tissue stability.
Purpose of Review: Attention deficit hyperactivity disorder (ADHD) shows high heritability in formal genetic studies. In our review article, we provide an overview on common and rare genetic risk variants for ADHD and their link to clinical practice.
Recent findings: The formal heritability of ADHD is about 80% and therefore higher than most other psychiatric diseases. However, recent studies estimate the proportion of heritability based on singlenucleotide variants (SNPs) at 22%. It is a matter of debate which genetic mechanisms explain this huge difference. While frequent variants in first mega-analyses of genome-wideassociation study data containing several thousand patients give the first genome-wide results, explaining only little variance, the methodologically more difficult analyses of rare variants are still in their infancy. Some rare genetic syndromes show higher prevalence for ADHD indicating a potential role for a small number of patients. In contrast, polygenic risk scores (PRS) could potentially be applied to every patient. We give an overview how PRS explain different behavioral phenotypes in ADHD and how they could be used for diagnosis and therapy prediction.
Summary: Knowledge about a patient’s genetic makeup is not yet mandatory for ADHD therapy or diagnosis. PRS however have been introduced successfully in other areas of clinical medicine, and their application in psychiatry will begin within the next years. In order to ensure competent advice for patients, knowledge of the current state of research is useful forpsychiatrists.
Voting advice applications (VAAs) are online tools providing voting advice to their users. This voting advice is based on the match between the answers of the user and the answers of several political parties to a common questionnaire on political attitudes. To visualize this match, VAAs use a wide array of visualisations, most popular of which are the two-dimensional political maps. These maps show the position of both the political parties and the user in the political landscape, allowing the user to understand both their own position and their relation to the political parties. To construct these maps, VAAs require scales that represent the main underlying dimensions of the political space. This makes the correct construction of these scales important if the VAA aims to provide accurate and helpful voting advice. This paper presents three criteria that assess if a VAA achieves this aim. To illustrate their usefulness, these three criteria—unidimensionality, reliability and quality—are used to assess the scales in the cross-national EUVox VAA, a VAA designed for the European Parliament elections of 2014. Using techniques from Mokken scaling analysis and categorical principal component analysis to capture the metrics, I find that most scales show low unidimensionality and reliability. Moreover, even while designers can—and sometimes do—use certain techniques to improve their scales, these improvements are rarely enough to overcome all of the problems regarding unidimensionality, reliability and quality. This leaves certain problems for the designers of VAAs and designers of similar type online surveys.
We explore the phase structure of the 1+1 dimensional Gross-Neveu model at finite number of fermion flavors using lattice field theory. Besides a chirally symmetric phase and a homogeneously broken phase we find evidence for the existence of an inhomogeneous phase, where the condensate is a spatially oscillating function. Our numerical results include a crude μ-T phase diagram.
We use recent results by Bainbridge–Chen–Gendron–Grushevsky–Möller on compactifications of strata of abelian differentials to give a comprehensive solution to the realizability problem for effective tropical canonical divisors in equicharacteristic zero. Given a pair (Γ,D) consisting of a stable tropical curve Γ and a divisor D in the canonical linear system on Γ, we give a purely combinatorial condition to decide whether there is a smooth curve X over a non-Archimedean field whose stable reduction has Γ as its dual tropical curve together with an effective canonical divisor KX that specializes to D.
Inhomogeneous phases in the Gross-Neveu model in 1 + 1 dimensions at finite number of flavors
(2020)
We explore the thermodynamics of the 1+1-dimensional Gross-Neveu (GN) model at a finite number of fermion flavors Nf, finite temperature, and finite chemical potential using lattice field theory. In the limit Nf→∞ the model has been solved analytically in the continuum. In this limit three phases exist: a massive phase, in which a homogeneous chiral condensate breaks chiral symmetry spontaneously; a massless symmetric phase with vanishing condensate; and most interestingly an inhomogeneous phase with a condensate, which oscillates in the spatial direction. In the present work we use chiral lattice fermions (naive fermions and SLAC fermions) to simulate the GN model with 2, 8, and 16 flavors. The results obtained with both discretizations are in agreement. Similarly as for Nf→∞ we find three distinct regimes in the phase diagram, characterized by a qualitatively different behavior of the two-point function of the condensate field. For Nf=8 we map out the phase diagram in detail and obtain an inhomogeneous region smaller as in the limit Nf→∞, where quantum fluctuations are suppressed. We also comment on the existence or absence of Goldstone bosons related to the breaking of translation invariance in 1+1 dimensions.
Erratum for: Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells.Journal of biological chemistry, 2002 Nov 15;277(46):43623-30. doi: 10.1074/jbc.M203926200. Epub 2002 Sep 5.
Type-II multiferroic materials, in which ferroelectric polarization is induced by inversion non-symmetric magnetic order, promise new and highly efficient multifunctional applications based on mutual control of magnetic and electric properties. However, to date this phenomenon is limited to low temperatures. Here we report giant pressure-dependence of the multiferroic critical temperature in CuBr2: at 4.5 GPa it is enhanced from 73.5 to 162 K, to our knowledge the highest TC ever reported for non-oxide type-II multiferroics. This growth shows no sign of saturating and the dielectric loss remains small under these high pressures. We establish the structure under pressure and demonstrate a 60\% increase in the two-magnon Raman energy scale up to 3.6 GPa. First-principles structural and magnetic energy calculations provide a quantitative explanation in terms of dramatically pressure-enhanced interactions between CuBr2 chains. These large, pressure-tuned magnetic interactions motivate structural control in cuprous halides as a route to applied high-temperature multiferroicity.
Recurrent cortical network dynamics plays a crucial role for sequential information processing in the brain. While the theoretical framework of reservoir computing provides a conceptual basis for the understanding of recurrent neural computation, it often requires manual adjustments of global network parameters, in particular of the spectral radius of the recurrent synaptic weight matrix. Being a mathematical and relatively complex quantity, the spectral radius is not readily accessible to biological neural networks, which generally adhere to the principle that information about the network state should either be encoded in local intrinsic dynamical quantities (e.g. membrane potentials), or transmitted via synaptic connectivity. We present two synaptic scaling rules for echo state networks that solely rely on locally accessible variables. Both rules work online, in the presence of a continuous stream of input signals. The first rule, termed flow control, is based on a local comparison between the mean squared recurrent membrane potential and the mean squared activity of the neuron itself. It is derived from a global scaling condition on the dynamic flow of neural activities and requires the separability of external and recurrent input currents. We gained further insight into the adaptation dynamics of flow control by using a mean field approximation on the variances of neural activities that allowed us to describe the interplay between network activity and adaptation as a two-dimensional dynamical system. The second rule that we considered, variance control, directly regulates the variance of neural activities by locally scaling the recurrent synaptic weights. The target set point of this homeostatic mechanism is dynamically determined as a function of the variance of the locally measured external input. This functional relation was derived from the same mean-field approach that was used to describe the approximate dynamics of flow control.
The effectiveness of the presented mechanisms was tested numerically using different external input protocols. The network performance after adaptation was evaluated by training the network to perform a time delayed XOR operation on binary sequences. As our main result, we found that flow control can reliably regulate the spectral radius under different input statistics, but precise tuning is negatively affected by interneural correlations. Furthermore, flow control showed a consistent task performance over a wide range of input strengths/variances. Variance control, on the other side, did not yield the desired spectral radii with the same precision. Moreover, task performance was less consistent across different input strengths.
Given the better performance and simpler mathematical form of flow control, we concluded that a local control of the spectral radius via an implicit adaptation scheme is a realistic alternative to approaches using classical “set point” homeostatic feedback controls of neural firing.
Author summary How can a neural network control its recurrent synaptic strengths such that network dynamics are optimal for sequential information processing? An important quantity in this respect, the spectral radius of the recurrent synaptic weight matrix, is a non-local quantity. Therefore, a direct calculation of the spectral radius is not feasible for biological networks. However, we show that there exist a local and biologically plausible adaptation mechanism, flow control, which allows to control the recurrent weight spectral radius while the network is operating under the influence of external inputs. Flow control is based on a theorem of random matrix theory, which is applicable if inter-synaptic correlations are weak. We apply the new adaption rule to echo-state networks having the task to perform a time-delayed XOR operation on random binary input sequences. We find that flow-controlled networks can adapt to a wide range of input strengths while retaining essentially constant task performance.
Recurrent cortical network dynamics plays a crucial role for sequential information processing in the brain. While the theoretical framework of reservoir computing provides a conceptual basis for the understanding of recurrent neural computation, it often requires manual adjustments of global network parameters, in particular of the spectral radius of the recurrent synaptic weight matrix. Being a mathematical and relatively complex quantity, the spectral radius is not readily accessible to biological neural networks, which generally adhere to the principle that information about the network state should either be encoded in local intrinsic dynamical quantities (e.g. membrane potentials), or transmitted via synaptic connectivity. We present two synaptic scaling rules for echo state networks that solely rely on locally accessible variables. Both rules work online, in the presence of a continuous stream of input signals. The first rule, termed flow control, is based on a local comparison between the mean squared recurrent membrane potential and the mean squared activity of the neuron itself. It is derived from a global scaling condition on the dynamic flow of neural activities and requires the separability of external and recurrent input currents. We gained further insight into the adaptation dynamics of flow control by using a mean field approximation on the variances of neural activities that allowed us to describe the interplay between network activity and adaptation as a two-dimensional dynamical system. The second rule that we considered, variance control, directly regulates the variance of neural activities by locally scaling the recurrent synaptic weights. The target set point of this homeostatic mechanism is dynamically determined as a function of the variance of the locally measured external input. This functional relation was derived from the same mean-field approach that was used to describe the approximate dynamics of flow control.
The effectiveness of the presented mechanisms was tested numerically using different external input protocols. The network performance after adaptation was evaluated by training the network to perform a time delayed XOR operation on binary sequences. As our main result, we found that flow control can reliably regulate the spectral radius under different input statistics, but precise tuning is negatively affected by interneural correlations. Furthermore, flow control showed a consistent task performance over a wide range of input strengths/variances. Variance control, on the other side, did not yield the desired spectral radii with the same precision. Moreover, task performance was less consistent across different input strengths.
Given the better performance and simpler mathematical form of flow control, we concluded that a local control of the spectral radius via an implicit adaptation scheme is a realistic alternative to approaches using classical “set point” homeostatic feedback controls of neural firing.
Author summary How can a neural network control its recurrent synaptic strengths such that network dynamics are optimal for sequential information processing? An important quantity in this respect, the spectral radius of the recurrent synaptic weight matrix, is a non-local quantity. Therefore, a direct calculation of the spectral radius is not feasible for biological networks. However, we show that there exist a local and biologically plausible adaptation mechanism, flow control, which allows to control the recurrent weight spectral radius while the network is operating under the influence of external inputs. Flow control is based on a theorem of random matrix theory, which is applicable if inter-synaptic correlations are weak. We apply the new adaption rule to echo-state networks having the task to perform a time-delayed XOR operation on random binary input sequences. We find that flow-controlled networks can adapt to a wide range of input strengths while retaining essentially constant task performance.
Evolution of nematic fluctuations in CaK(Fe1−xNix)4As4 with spin-vortex crystal magnetic order
(2020)
The CaK(Fe1−xNix)4As4 superconductors resemble the archetypal 122-type iron-based materials but have a crystal structure with distinctly lower symmetry. This family hosts one of the few examples of the so-called spin-vortex crystal magnetic order, a non-collinear magnetic configuration that preserves tetragonal symmetry, in contrast to the orthorhombic collinear stripe-type magnetic configuration common to the 122-type systems. Thus, nematic order is completely absent from its phase diagram. To investigate the evolution of nematic fluctuations in such a case, we present elastoresistance and elastic modulus measurements in CaK(Fe1−xNix)4As4 (x=0−0.05) combined with phenomenological modeling and density functional theory. We find clear experimental signatures of considerable nematic fluctuations, including softening of the Young's modulus Y[110] and a Curie-Weiss type divergence of the B2g elastoresistance coefficient in CaK(Fe0.951Ni0.049)4As4. Overall, nematic fluctuations within this series bear strong similarities to the hole-doped Ba1−xKxFe2As2 series, including a substitution-induced sign change. Our theoretical analysis addresses the effect of the specific crystal symmetry of the 1144-type structure in determining its magnetic ground state and on the nematic fluctuations.
Deconfinement of Mott localized electrons into topological and spin–orbit-coupled Dirac fermions
(2020)
The interplay of electronic correlations, spin–orbit coupling and topology holds promise for the realization of exotic states of quantum matter. Models of strongly interacting electrons on honeycomb lattices have revealed rich phase diagrams featuring unconventional quantum states including chiral superconductivity and correlated quantum spin Hall insulators intertwining with complex magnetic order. Material realizations of these electronic states are, however, scarce or inexistent. In this work, we propose and show that stacking 1T-TaSe2 into bilayers can deconfine electrons from a deep Mott insulating state in the monolayer to a system of correlated Dirac fermions subject to sizable spin–orbit coupling in the bilayer. 1T-TaSe2 develops a Star-of-David charge density wave pattern in each layer. When the Star-of-David centers belonging to two adyacent layers are stacked in a honeycomb pattern, the system realizes a generalized Kane–Mele–Hubbard model in a regime where Dirac semimetallic states are subject to significant Mott–Hubbard interactions and spin–orbit coupling. At charge neutrality, the system is close to a quantum phase transition between a quantum spin Hall and an antiferromagnetic insulator. We identify a perpendicular electric field and the twisting angle as two knobs to control topology and spin–orbit coupling in the system. Their combination can drive it across hitherto unexplored grounds of correlated electron physics, including a quantum tricritical point and an exotic first-order topological phase transition.
Cancer‐associated venous thromboembolism (VTE) is a frequent, potentially life‐threatening event that complicates cancer management. Anticoagulants are the cornerstone of therapy for the treatment and prevention of cancer‐associated thrombosis (CAT); factor Xa–inhibiting direct oral anticoagulants (DOACs; apixaban, edoxaban, and rivaroxaban), which have long been recommended for the treatment of VTE in patients without cancer, have been investigated in this setting. The first randomized comparisons of DOACs against low‐molecular‐weight heparin for the treatment of CAT indicated that DOACs are efficacious in this setting, with findings reflected in recent updates to published guidance on CAT treatment. However, the higher risk of bleeding events (particularly in the gastrointestinal tract) with DOACs highlights the need for appropriate patient selection. Further insights will be gained from additional studies that are ongoing or awaiting publication. The efficacy and safety of DOAC thromboprophylaxis in ambulatory patients with cancer at a high risk of VTE have also been assessed in placebo‐controlled randomized controlled trials of apixaban and rivaroxaban. Both studies showed efficacy benefits with DOACs, but both studies also showed a nonsignificant increase in major bleeding events while on treatment. This review summarizes the evidence base for rivaroxaban use in CAT, the patient profile potentially most suited to DOAC use, and ongoing controversies under investigation. We also describe ongoing studies from the CALLISTO (Cancer Associated thrombosis—expLoring soLutions for patients through Treatment and Prevention with RivarOxaban) program, which comprises several randomized clinical trials and real‐world evidence studies, including investigator‐initiated research.
The study of (anti-)deuteron production in pp collisions has proven to be a powerful tool to investigate the formation mechanism of loosely bound states in high energy hadronic collisions. In this paper the production of (anti-)deuterons is studied as a function of the charged particle multiplicity in inelastic pp collisions at s√=13 TeV using the ALICE experiment. Thanks to the large accumulated integrated luminosity, it has been possible to measure (anti-)deuteron production in pp collisions up to the same charged particle multiplicity (dNch/dη∼26) as measured in p-Pb collisions at similar centre-of-mass energies. Within the uncertainties, the deuteron yield in pp collisions resembles the one in p-Pb interactions, suggesting a common formation mechanism behind the production of light nuclei in hadronic interactions. In this context the measurements are compared with the expectations of coalescence and Statistical Hadronisation Models (SHM).
The production of the Λ(1520) baryonic resonance has been measured at midrapidity in inelastic pp collisions at s√ = 7 TeV and in p-Pb collisions at sNN−−−√ = 5.02 TeV for non-single diffractive events and in multiplicity classes. The resonance is reconstructed through its hadronic decay channel Λ(1520) → pK− and the charge conjugate with the ALICE detector. The integrated yields and mean transverse momenta are calculated from the measured transverse momentum distributions in pp and p-Pb collisions. The mean transverse momenta follow mass ordering as previously observed for other hyperons in the same collision systems. A Blast-Wave function constrained by other light hadrons (π, K, K0S, p, Λ) describes the shape of the Λ(1520) transverse momentum distribution up to 3.5 GeV/c in p-Pb collisions. In the framework of this model, this observation suggests that the Λ(1520) resonance participates in the same collective radial flow as other light hadrons. The ratio of the yield of Λ(1520) to the yield of the ground state particle Λ remains constant as a function of charged-particle multiplicity, suggesting that there is no net effect of the hadronic phase in p-Pb collisions on the Λ(1520) yield.
Identifying co-expression of lipid species is challenging, but indispensable to identify novel therapeutic targets for breast cancer treatment. Lipid metabolism is often dysregulated in cancer cells, and changes in lipid metabolism affect cellular processes such as proliferation, autophagy, and tumor development. In addition to mRNA analysis of sphingolipid metabolizing enzymes, we performed liquid chromatography time-of-flight mass spectrometry analysis in three breast cancer cell lines. These breast cancer cell lines differ in estrogen receptor and G-protein coupled estrogen receptor 1 status. Our data show that sphingolipids and non-sphingolipids are strongly increased in SKBr3 cells. SKBr3 cells are estrogen receptor negative and G-protein coupled estrogen receptor 1 positive. Treatment with G15, a G-protein coupled estrogen receptor 1 antagonist, abolishes the effect of increased sphingolipid and non-sphingolipid levels in SKBr3 cells. In particular, ether lipids are expressed at much higher levels in cancer compared to normal cells and are strongly increased in SKBr3 cells. Our analysis reveals that this is accompanied by increased sphingolipid levels such as ceramide, sphingadiene-ceramide and sphingomyelin. This shows the importance of focusing on more than one lipid class when investigating molecular mechanisms in breast cancer cells. Our analysis allows unbiased screening for different lipid classes leading to identification of co-expression patterns of lipids in the context of breast cancer. Co-expression of different lipid classes could influence tumorigenic potential of breast cancer cells. Identification of co-regulated lipid species is important to achieve improved breast cancer treatment outcome.
We study in detail the nuclear aspects of a neutron-star merger in which deconfinement to quark matter takes place. For this purpose, we make use of the Chiral Mean Field (CMF) model, an effective relativistic model that includes self-consistent chiral symmetry restoration and deconfinement to quark matter and, for this reason, predicts the existence of different degrees of freedom depending on the local density/chemical potential and temperature. We then use the out-of-chemical-equilibrium finite-temperature CMF equation of state in full general-relativistic simulations to analyze which regions of different QCD phase diagrams are probed and which conditions, such as strangeness and entropy, are generated when a strong first-order phase transition appears. We also investigate the amount of electrons present in different stages of the merger and discuss how far from chemical equilibrium they can be and, finally, draw some comparisons with matter created in supernova explosions and heavy-ion collisions.
Evaluation of a rapid turn-over, fully-automated ADAMTS13 activity assay: a method comparison study
(2020)
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy caused by severely reduced activity of the von-Willebrand factor-cleaving protease ADAMTS13, mainly caused by anti-ADAMTS-13 antibodies. Although several test systems for ADAMTS13 measurement exist, long turn-around times hamper the usability in daily practice. We performed a method comparison study for two commercially available ADAMTS13 assays and evaluated the agreement between the fully-automated rapid turn-over HemosIL AcuStar ADAMTS13 Activity assay and the manually performed TECHNOZYM ADAMTS-13 Activity assay. Twenty-four paired test samples derived from 10 consecutively recruited patients (n = 8, acquired TTP; n = 1, atypical hemolytic uremic syndrome; n = 1, control), of which nine test samples were collected in case of clinically apparent TTP and 13 samples were collected from TTP patients in clinical remission were included. Overall correlation between the TECHNOZYM and AcuStar assay was good with a Pearson R of 0.93 (p < 0.001). Agreement between the assays assessed with the Passing–Bablok analysis showed high agreement with an Intercept of − 2.56 (95% confidence interval [CI], − 5.07 to − 0.86) and Slope of 1.04 (95% CI 0.84–1.17). The absolute mean bias was 2.54% (standard difference [SD], 6.38%; 95% CI to 10.0–15.05%). Intra-method reliability was high with an absolute mean bias of − 0.13% (SD 3.21%; 95% CI to 6.42–6.16%). The observer agreement for categorial thresholds (> or < 10% ADAMTS3 activity) was kappa = 0.82 (95% CI 0.59–1.0). Conclusively, overall agreement between the testing methods was sufficient and we support previously published data suggesting the AcuStar assay being a valuable and accurate tool for ADAMTS13 activity testing and TTP diagnostics.
Corporate governance is the set of rules, be they legal or self-regulatory, practices and processes pursuant to which an insurance undertaking is administrated. Good corporate governance is not only key to establishing oneself and succeeding in a competitive environment but also to safeguarding the interests of all stakeholders in an insurance undertaking. It is insofar not surprising that mandatory requirements on the administration of insurance undertakings have become rather prolific in recent years, in an attempt by regulators to protect especially policyholders against perceived risks hailing from improperly governed insurance undertakings. In Germany this has been regarded by many undertakings as an overly paternalistic approach of the legislator, especially considering that the German insurance sector has experienced for decades if not centuries a remarkably low number of insolvencies and that German insurers were neither the trigger nor the (especially) endangered actors in the financial crisis commencing in 2007. Notwithstanding the true core of this criticism, that the insurance industry was taken to a certain degree hostage by the shortcomings within the banking sector, the reform of German Insurance Supervisory Law via implementation of the Solvency II-System has brought many advances in the sense of better governance of insurance undertakings and has also brought to light many deficiencies that the administration of some insurance undertakings may have suffered from in the past, which are now more properly addressed.
Macrophages acquire anti-inflammatory and proresolving functions to facilitate resolution of inflammation and promote tissue repair. While alternatively activated macrophages (AAMs), also referred to as M2 macrophages, polarized by type 2 (Th2) cytokines IL-4 or IL-13 contribute to the suppression of inflammatory responses and play a pivotal role in wound healing, contemporaneous exposure to apoptotic cells (ACs) potentiates the expression of anti-inflammatory and tissue repair genes. Given that liver X receptors (LXRs), which coordinate sterol metabolism and immune cell function, play an essential role in the clearance of ACs, we investigated whether LXR activation following engulfment of ACs selectively potentiates the expression of Th2 cytokine-dependent genes in primary human AAMs. We show that AC uptake simultaneously upregulates LXR-dependent, but suppresses SREBP-2-dependent gene expression in macrophages, which are both prevented by inhibiting Niemann–Pick C1 (NPC1)-mediated sterol transport from lysosomes. Concurrently, macrophages accumulate sterol biosynthetic intermediates desmosterol, lathosterol, lanosterol, and dihydrolanosterol but not cholesterol-derived oxysterols. Using global transcriptome analysis, we identify anti-inflammatory and proresolving genes including interleukin-1 receptor antagonist (IL1RN) and arachidonate 15-lipoxygenase (ALOX15) whose expression are selectively potentiated in macrophages upon concomitant exposure to ACs or LXR agonist T0901317 (T09) and Th2 cytokines. We show priming macrophages via LXR activation enhances the cellular capacity to synthesize inflammation-suppressing specialized proresolving mediator (SPM) precursors 15-HETE and 17-HDHA as well as resolvin D5. Silencing LXRα and LXRβ in macrophages attenuates the potentiation of ALOX15 expression by concomitant stimulation of ACs or T09 and IL-13. Collectively, we identify a previously unrecognized mechanism of regulation whereby LXR integrates AC uptake to selectively shape Th2-dependent gene expression in AAMs.
Mongolian spots (MS) are congenital dermal conditions resulting from neural crest-derived melanocytes migration to the skin during embryogenesis. MS incidences are highly variable in different populations. Morphologically, MS present as hyperpigmented maculae of varying size and form, ranging from round spots of 1 cm in diameter to extensive discolorations covering predominantly the lower back and buttocks. Due to their coloring, which is also dependent on the skin type, MS may mimic hematoma thus posing a challenge on the physician conducting examinations of children in cases of suspected child abuse. In the present study, MS incidences and distribution, as well as skin types, were documented in a collective of 253 children examined on the basis of suspected child abuse. From these data, a classification scheme was derived to document MS and to help identify cases with a need for recurrent examination for unambiguous interpretation of initial findings alongside the main decisive factors for re-examination such as general circumstances of the initial examination (e. g., experience of the examiner, lighting conditions) and given dermatological conditions of the patient (e. g., diaper rash).
Objective: Relative to urban populations, rural patients may have more limited access to care, which may undermine timely bladder cancer (BCa) diagnosis and even survival.
Methods: We tested the effect of residency status (rural areas [RA < 2500 inhabitants] vs. urban clusters [UC ≥ 2500 inhabitants] vs. urbanized areas [UA, ≥50,000 inhabitants]) on BCa stage at presentation, as well as on cancer-specific mortality (CSM) and other cause mortality (OCM), according to the US Census Bureau definition. Multivariate competing risks regression (CRR) models were fitted after matching of RA or UC with UA in stage-stratified analyses.
Results: Of 222,330 patients, 3496 (1.6%) resided in RA, 25,462 (11.5%) in UC and 193,372 (87%) in UA. Age, tumor stage, radical cystectomy rates or chemotherapy use were comparable between RA, UC and UA (all p > 0.05). At 10 years, RA was associated with highest OCM followed by UC and UA (30.9% vs. 27.7% vs. 25.6%, p < 0.01). Similarly, CSM was also marginally higher in RA or UC vs. UA (20.0% vs. 20.1% vs. 18.8%, p = 0.01). In stage-stratified, fully matched CRR analyses, increased OCM and CSM only applied to stage T1 BCa patients.
Conclusion: We did not observe meaningful differences in access to treatment or stage distribution, according to residency status. However, RA and to a lesser extent UC residency status, were associated with higher OCM and marginally higher CSM in T1N0M0 patients. This observation should be further validated or refuted in additional epidemiological investigations.
There is limited knowledge on the prevalence and risk factors of diabetic retinopathy (DR) in dialysis patients. We have investigated the association between diabetes mellitus and lipid-related biomarkers and retinopathy in hemodialysis patients. We reviewed 1,255 hemodialysis patients with type 2 diabetes mellitus (T2DM) who participated in the German Diabetes and Dialysis Study (4D Study). Associations between categorical clinical, biochemical variables and diabetic retinopathy were examined by logistic regression. On average, patients were 66 ± 8 years of age, 54% were male and the HbA1c was 6.7% ± 1.3%. DR, found in 71% of the patients, was significantly and positively associated with fasting glucose, HbA1c, time on dialysis, age, systolic blood pressure, body mass index and the prevalence of other microvascular diseases (e.g. neuropathy). Unexpectedly, DR was associated with high HDL cholesterol and high apolipoproteins AI and AII. Patients with coronary artery disease were less likely to have DR. DR was not associated with gender, smoking, diastolic blood pressure, VLDL cholesterol, triglycerides, and LDL cholesterol. In summary, the prevalence of DR in patients with type 2 diabetes mellitus requiring hemodialysis is higher than in patients suffering from T2DM, who do not receive hemodialysis. DR was positively related to systolic blood pressure (BP), glucometabolic control, and, paradoxically, HDL cholesterol. This data suggests that glucose and blood pressure control may delay the development of DR in patients with diabetes mellitus on dialysis.
The genus Ebolavirus comprises some of the deadliest viruses for primates and humans and associated disease outbreaks are increasing in Africa. Different evidence suggests that bats are putative reservoir hosts and play a major role in the transmission cycle of these filoviruses. Thus, detailed knowledge about their distribution might improve risk estimations of where future disease outbreaks might occur. A MaxEnt niche modelling approach based on climatic variables and land cover was used to investigate the potential distribution of 9 bat species associated to the Zaire ebolavirus. This viral species has led to major Ebola outbreaks in Africa and is known for causing high mortalities. Modelling results suggest suitable areas mainly in the areas near the coasts of West Africa with extensions into Central Africa, where almost all of the 9 species studied find suitable habitat conditions. Previous spillover events and outbreak sites of the virus are covered by the modelled distribution of 3 bat species that have been tested positive for the virus not only using serology tests but also PCR methods. Modelling the habitat suitability of the bats is an important step that can benefit public information campaigns and may ultimately help control future outbreaks of the disease.
Aktuelle wissenschaftliche Auseinandersetzungen mit dem Sinnerleben Beschäftigter thematisieren vor allem die Problematik eines belastungsbedingten Sinnverlustes. Danach leiden immer mehr Beschäftigte darunter, ihre Arbeit nicht mehr als sinnvoll empfinden zu können. Eine solche Perspektive lässt allerdings die subjektiven Gestaltungsleistungen und Aneignungsformen von Arbeit aus dem Blick geraten. Diesen wendet sich der Beitrag zu, indem er danach fragt, inwieweit sich unterschiedliche Formen der Aneignung von Arbeit identifizieren lassen. Auf der Basis von Interviews mit vierzig hochqualifizierten Beschäftigten werden drei unterschiedliche Aneignungsmodi mit ihren inhärenten Ambivalenzen identifiziert. Jeder Modus steht für eine spezifische Sichtweise auf die eigenen Gestaltungsmöglichkeiten und für eine Form der primären Sinnzuschreibung in der Arbeit. Differenziert werden drei Idealtypen – „progressive Sinngestaltung“, „widerständige Sinnbewahrung“ sowie „pragmatische Sinnbewahrung“ –, anhand derer die Heterogenität und die Ambivalenzen der Aneignung professioneller Arbeit deutlich werden. Der Beitrag liefert so Erkenntnisse über die subjektiven Praktiken des Bedeutsam-Machens von Arbeit und trägt zur Erforschung des Zusammenspiels von Arbeit und Subjektivität bei.
Objectives: Evaluation of surgical and non-surgical air-polishing in vitro efficacy for implant surface decontamination.
Material and methods: One hundred eighty implants were distributed to three differently angulated bone defect models (30°, 60°, 90°). Biofilm was imitated using indelible red color. Sixty implants were used for each defect, 20 of which were air-polished with three different types of glycine air powder abrasion (GAPA1–3) combinations. Within 20 equally air-polished implants, a surgical and non-surgical (with/without mucosa mask) procedure were simulated. All implants were photographed to determine the uncleaned surface. Changes in surface morphology were assessed using scanning electron micrographs (SEM).
Results: Cleaning efficacy did not show any significant differences between GAPA1–3 for surgical and non-surgical application. Within a cleaning method significant (p < 0.001) differences for GAPA2 between 30° (11.77 ± 2.73%) and 90° (7.25 ± 1.42%) in the non-surgical and 30° (8.26 ± 1.02%) and 60° (5.02 ± 0.84%) in the surgical simulation occurred. The surgical use of air-polishing (6.68 ± 1.66%) was significantly superior (p < 0.001) to the non-surgical (10.13 ± 2.75%). SEM micrographs showed no surface damages after use of GAPA.
Conclusions: Air-polishing is an efficient, surface protective method for surgical and non-surgical implant surface decontamination in this in vitro model. No method resulted in a complete cleaning of the implant surface.
Clinical relevance: Air-polishing appears to be promising for implant surface decontamination regardless of the device.
Purpose: COVID-19 pandemic had multiple influences on the social, industrial, and medical situation in all affected countries. Measures of obligatory medical confinement were suspensions of scheduled non-emergent surgical procedures and outpatients’ clinics as well as overall access restrictions to hospitals and medical practices. The aim of this retrospective study was to assess if the obligatory confinement (lockdown) had an effect on the number of appendectomies (during and after the period of lockdown).
Methods: This retrospective study was based on anonymized nationwide administrative claims data of the German Local General Sickness Fund (AOK). Patients admitted for diseases of the appendix (ICD-10: K35-K38) or abdominal and pelvic pain (ICD-10: R10) who underwent an appendectomy (OPS: 5-470) were included. The study period included 6 weeks of German lockdown (16 March–26 April 2020) as well as 6 weeks before (03 February–15 March 2020) and after (27 April–07 June 2020). These periods were compared to the respective one in 2018 and 2019.
Results: The overall number of appendectomies was significantly reduced during the lockdown time in 2020 compared to that in 2018 and 2019. This decrease affects only appendectomies due to acute simple (ICD-10: K35.30, K35.8) and non-acute appendicitis (ICD-10: K36-K38, R10). Numbers for appendectomies in acute complex appendicitis remained unchanged. Female patients and in the age group 1–18 years showed the strongest decrease in number of cases.
Conclusion: The lockdown in Germany resulted in a decreased number of appendectomies. This affected mainly appendectomies in simple acute and non-acute appendicitis, but not complicated acute appendicitis. The study gives no evidence that the confinement measures resulted in a deterioration of medical care for appendicitis.
Background: Alterations in the SCN5A gene encoding the cardiac sodium channel Nav1.5 have been linked to a number of arrhythmia syndromes and diseases including long-QT syndrome (LQTS), Brugada syndrome (BrS) and dilative cardiomyopathy (DCM), which may predispose to fatal arrhythmias and sudden death. We identified the heterozygous variant c.316A > G, p.(Ser106Gly) in a 35-year-old patient with survived cardiac arrest. In the present study, we aimed to investigate the functional impact of the variant to clarify the medical relevance.
Methods: Mutant as well as wild type GFP tagged Nav1.5 channels were expressed in HEK293 cells. We performed functional characterization experiments using patch-clamp technique.
Results: Electrophysiological measurements indicated, that the detected missense variant alters Nav1.5 channel functionality leading to a gain-of-function effect. Cells expressing S106G channels show an increase in Nav1.5 current over the entire voltage window.
Conclusion: The results support the assumption that the detected sequence aberration alters Nav1.5 channel function and may predispose to cardiac arrhythmias and sudden cardiac death.
Objectives: To immunohistochemically characterize and correlate macrophage M1/M2 polarization status with disease severity at peri-implantitis sites.
Materials and methods: A total of twenty patients (n = 20 implants) diagnosed with peri-implantitis (i.e., bleeding on probing with or without suppuration, probing depths ≥ 6 mm, and radiographic marginal bone loss ≥ 3 mm) were included. The severity of peri-implantitis was classified according to established criteria (i.e., slight, moderate, and advanced). Granulation tissue biopsies were obtained during surgical therapy and prepared for immunohistological assessment and macrophage polarization characterization. Macrophages, M1, and M2 phenotypes were identified through immunohistochemical markers (i.e., CD68, CD80, and CD206) and quantified through histomorphometrical analyses.
Results: Macrophages exhibiting a positive CD68 expression occupied a mean proportion of 14.36% (95% CI 11.4–17.2) of the inflammatory connective tissue (ICT) area. Positive M1 (CD80) and M2 (CD206) macrophages occupied a mean value of 7.07% (95% CI 5.9–9.4) and 5.22% (95% CI 3.8–6.6) of the ICT, respectively. The mean M1/M2 ratio was 1.56 (95% CI 1–12–1.9). Advanced peri-implantitis cases expressed a significantly higher M1 (%) when compared with M2 (%) expression. There was a significant correlation between CD68 (%) and M1 (%) expression and probing depth (PD) values.
Conclusion: The present immunohistochemical analysis suggests that macrophages constitute a considerable proportion of the inflammatory cellular composition at peri-implantitis sites, revealing a significant higher expression for M1 inflammatory phenotype at advanced peri-implantitis sites, which could possibly play a critical role in disease progression.
Clinical relevance: Macrophages have critical functions to establish homeostasis and disease. Bacteria might induce oral dysbiosis unbalancing the host’s immunological response and triggering inflammation around dental implants. M1/M2 status could possibly reveal peri-implantitis’ underlying pathogenesis.
Respiratory complex I catalyzes electron transfer from NADH to ubiquinone (Q) coupled to vectorial proton translocation across the inner mitochondrial membrane. Despite recent progress in structure determination of this very large membrane protein complex, the coupling mechanism is a matter of ongoing debate and the function of accessory subunits surrounding the canonical core subunits is essentially unknown. Concerted rearrangements within a cluster of conserved loops of central subunits NDUFS2 (β1-β2S2 loop), ND1 (TMH5-6ND1 loop) and ND3 (TMH1-2ND3 loop) were suggested to be critical for its proton pumping mechanism. Here, we show that stabilization of the TMH1-2ND3 loop by accessory subunit LYRM6 (NDUFA6) is pivotal for energy conversion by mitochondrial complex I. We determined the high-resolution structure of inactive mutant F89ALYRM6 of eukaryotic complex I from the yeast Yarrowia lipolytica and found long-range structural changes affecting the entire loop cluster. In atomistic molecular dynamics simulations of the mutant, we observed conformational transitions in the loop cluster that disrupted a putative pathway for delivery of substrate protons required in Q redox chemistry. Our results elucidate in detail the essential role of accessory subunit LYRM6 for the function of eukaryotic complex I and offer clues on its redox-linked proton pumping mechanism.
Vor dem Hintergrund der zunehmenden Veränderung des städtischen Lebensumfeldes durch Gentrifizierung, investorenfreundliche Stadtpolitik, Privatisierung öffentlicher Räume, Einsparung öffentlicher Investitionen und den Abbau demokratischer Beteiligungsinstrumente haben wir uns gefragt: Wie könnte eine solidarische Stadt der Zukunft aussehen? Welche Gegenentwürfe zu aktuell herrschenden Paradigmen in der Stadtentwicklung zeigen uns Wege aus der Alternativlosigkeit hin zu einer solidarischen Praxis auf Quartiersebene? Im Rahmen einer angewandten kritischen Geografie möchten wir zeigen, dass es eine Vielzahl an Projekten und Initiativen gibt, die die Kreativlosigkeit, zu der uns der Neoliberalismus erzogen hat, durchbrechen und an konkreten Ideen und deren praktischer Umsetzung arbeiten. Als theoretische Annäherung dafür setzen wir uns mit Utopien und deren Potenzialen für eine politische Praxis auseinander. Da wir selbst im Kontext stadtpolitischer Gruppen engagiert sind, nutzen wir die aktivistische Stadtforschung als methodischen Rahmen unserer Forschung. Daraus entstanden ist ein Faltblatt, der „Kompass für ein solidarisches Quartier“, welcher als aktivistisches Werkzeug und Ideengeber für die konkrete Umsetzung transformativer Stadtpolitik dienen soll.
The production of K∗(892)0 and ϕ(1020) in pp collisions at s√ = 8 TeV was measured using Run 1 data collected by the ALICE collaboration at the LHC. The pT-differential yields d2N/dydpT in the range 0<pT<20 GeV/c for K∗0 and 0.4<pT<16 GeV/c for ϕ have been measured at midrapidity, |y|<0.5. Moreover, improved measurements of the K∗(892)0 and ϕ(1020) at s√=7TeV are presented. The collision energy dependence of pT distributions, pT-integrated yields and particle ratios in inelastic pp collisions are examined. The results are also compared with different collision systems. The values of the particle ratios are found to be similar to those measured at other LHC energies. In pp collisions a hardening of the particle spectra is observed with increasing energy, but at the same time it is also observed that the relative particle abundances are independent of the collision energy. The pT-differential yields of K∗0 and ϕ in pp collisions at s√=8 TeV are compared with the expectations of different Monte Carlo event generators.
The elliptic flow (v2) of (anti-)3He is measured in Pb-Pb collisions at sNN−−−√ = 5.02 TeV in the transverse-momentum (pT) range of 2-6 GeV/c for the centrality classes 0-20%, 20-40%, and 40-60% using the event-plane method. This measurement is compared to that of pions, kaons, and protons at the same center-of-mass energy. A clear mass ordering is observed at low pT, as expected from relativistic hydrodynamics. The violation of the scaling of v2 with the number of constituent quarks at low pT, already observed for identified hadrons and deuterons at LHC energies, is confirmed also for (anti-)3He. The elliptic flow of (anti-)3He is underestimated by the Blast-Wave model and overestimated by a simple coalescence approach based on nucleon scaling. The elliptic flow of (anti-)3He measured in the centrality classes 0-20% and 20-40% is well described by a more sophisticated coalescence model where the phase-space distributions of protons and neutrons are generated using the iEBE-VISHNU hybrid model with AMPT initial conditions.
The transverse momentum (pT) differential yields of (anti-)3He and (anti-)3H measured in p-Pb collisions at sNN−−−√ = 5.02 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The ratios of the pT-integrated yields of (anti-)3He and (anti-)3H to the proton yields are reported, as well as the pT dependence of the coalescence parameters B3 for (anti-)3He and (anti-)3H. For (anti-)3He, the results obtained in four classes of the mean charged-particle multiplicity density are also discussed. These results are compared to predictions from a canonical statistical hadronization model and coalescence approaches. An upper limit on the total yield of 4He¯ is determined.
Measurements of the inclusive J/ψ yield as a function of charged-particle pseudorapidity density dNch/dη in pp collisions at s√ = 13 TeV with ALICE at the LHC are reported. The J/ψ meson yield is measured at midrapidity (|y|<0.9) in the dielectron channel, for events selected based on the charged-particle multiplicity at midrapidity (|η|<1) and at forward rapidity (−3.7<η<−1.7 and 2.8<η<5.1); both observables are normalized to their corresponding averages in minimum bias events. The increase of the normalized J/ψ yield with normalized dN/dη is significantly stronger than linear and dependent on the transverse momentum. The data are compared to theoretical predictions, which describe the observed trends well, albeit not always quantitatively.
The production cross section of prompt Λ+c charmed baryons was measured with the ALICE detector at the LHC at midrapidity in proton-proton (pp) and proton-lead (p-Pb) collisions at a centre-of-mass energy per nucleon pair of sNN−−−√=5.02 TeV. The Λ+c and Λ¯¯¯¯−c baryons were reconstructed in the hadronic decay channels Λ+c→pK−π+ and Λ+c→pK0S and respective charge conjugates. The measured differential cross sections as a function of transverse momentum (pT) and the pT-integrated Λ+c production cross section in pp and in p-Pb collisions are presented. The Λ+c nuclear modification factor (RpPb), calculated from the cross sections in pp and in p-Pb collisions, is presented and compared with the RpPb of D mesons. The Λ+c/D0 ratio is also presented and compared with the light-flavour baryon-to-meson ratios p/π and Λ/K0S, and measurements from other LHC experiments. The results are compared to predictions from model calculations and Monte Carlo event generators.
The ALICE collaboration at the CERN LHC reports novel measurements of jet substructure in pp collisions at s√= 7 TeV and central Pb-Pb collisions at sNN−−−√ = 2.76 TeV. Jet substructure of track-based jets is explored via iterative declustering and grooming techniques. We present the measurement of the momentum sharing of two-prong substructure exposed via grooming, the zg, and its dependence on the opening angle, in both pp and Pb-Pb collisions. We also present the first measurement of the distribution of the number of branches obtained in the iterative declustering of the jet, which is interpreted as the number of its hard splittings. In Pb-Pb collisions, we observe a suppression of symmetric splittings at large opening angles and an enhancement of splittings at small opening angles relative to pp collisions, with no significant modification of the number of splittings. The results are compared to predictions from various Monte Carlo event generators to test the role of important concepts in the evolution of the jet in the medium such as color coherence.
The transverse momentum (pT) differential yields of (anti-)3He and (anti-)3H measured in p-Pb collisions at sNN−−−√ = 5.02 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The ratios of the pT-integrated yields of (anti-)3He and (anti-)3H to the proton yields are reported, as well as the pT dependence of the coalescence parameters B3 for (anti-)3He and (anti-)3H. For (anti-)3He, the results obtained in four classes of the mean charged-particle multiplicity density are also discussed. These results are compared to predictions from a canonical statistical hadronization model and coalescence approaches. An upper limit on the total yield of 4He¯ is determined.
Jet fragmentation transverse momentum distributions in pp and p–Pb collisions at √sNN = 5.02 TeV
(2020)
Jet fragmentation transverse momentum (jT) distributions are measured in proton-proton (pp) and proton-lead (p-Pb) collisions at sNN−−−√ = 5.02 TeV with the ALICE experiment at the LHC. Jets are reconstructed with the ALICE tracking detectors and electromagnetic calorimeter using the anti-kT algorithm with resolution parameter R=0.4 in the pseudorapidity range |η|<0.25. The jT values are calculated for charged particles inside a fixed cone with a radius R=0.4 around the reconstructed jet axis. The measured jT distributions are compared with a variety of parton-shower models. Herwig and PYTHIA 8 based models describe the data well for the higher jT region, while they underestimate the lower jT region. The jT distributions are further characterised by fitting them with a function composed of an inverse gamma function for higher jT values (called the "wide component"), related to the perturbative component of the fragmentation process, and with a Gaussian for lower jT values (called the "narrow component"), predominantly connected to the hadronisation process. The width of the Gaussian has only a weak dependence on jet transverse momentum, while that of the inverse gamma function increases with increasing jet transverse momentum. For the narrow component, the measured trends are successfully described by all models except for Herwig. For the wide component, Herwig and PYTHIA 8 based models slightly underestimate the data for the higher jet transverse momentum region. These measurements set constraints on models of jet fragmentation and hadronisation.
The inclusive production of the J/ψ and ψ(2S) charmonium states is studied as a function of centrality in p-Pb collisions at a centre-of-mass energy per nucleon pair sNN−−−√=8.16 TeV at the LHC. The measurement is performed in the dimuon decay channel with the ALICE apparatus in the centre-of-mass rapidity intervals −4.46<ycms<−2.96 (Pb-going direction) and 2.03<ycms<3.53 (p-going direction), down to zero transverse momentum (pT). The J/ψ and ψ(2S) production cross sections are evaluated as a function of the collision centrality, estimated through the energy deposited in the zero degree calorimeter located in the Pb-going direction. The pT-differential J/ψ production cross section is measured at backward and forward rapidity for several centrality classes, together with the corresponding average ⟨pT⟩ and ⟨p2T⟩ values. The nuclear effects affecting the production of both charmonium states are studied using the nuclear modification factor. In the p-going direction, a suppression of the production of both charmonium states is observed, which seems to increase from peripheral to central collisions. In the Pb-going direction, however, the centrality dependence is different for the two states: the nuclear modification factor of the J/ψ increases from below unity in peripheral collisions to above unity in central collisions, while for the ψ(2S) it stays below or consistent with unity for all centralities with no significant centrality dependence. The results are compared with measurements in p-Pb collisions at sNN−−−√=5.02 TeV and no significant dependence on the energy of the collision is observed. Finally, the results are compared with theoretical models implementing various nuclear matter effects.
This paper presents the measurements of π±, K±, p and p¯ transverse momentum (pT) spectra as a function of charged-particle multiplicity density in proton-proton (pp) collisions at s√ = 13 TeV with the ALICE detector at the LHC. Such study allows us to isolate the center-of-mass energy dependence of light-flavour particle production. The measurements reported here cover a pT range from 0.1 GeV/c to 20 GeV/c and are done in the rapidity interval |y|<0.5. The pT-differential particle ratios exhibit an evolution with multiplicity, similar to that observed in pp collisions at s√ = 7 TeV, which is qualitatively described by some of the hydrodynamical and pQCD-inspired models discussed in this paper. Furthermore, the pT-integrated hadron-to-pion yield ratios measured in pp collisions at two different center-of-mass energies are consistent when compared at similar multiplicities. This also extends to strange and multi-strange hadrons, suggesting that, at LHC energies, particle hadrochemistry scales with particle multiplicity the same way under different collision energies and colliding systems.
Z-boson production in p–Pb collisions at √sNN = 8.16 TeV and Pb–Pb collisions at √sNN = 5.02 TeV
(2020)
Measurement of Z-boson production in p-Pb collisions at sNN−−−√=8.16 TeV and Pb-Pb collisions at sNN−−−√=5.02 TeV is reported. It is performed in the dimuon decay channel, through the detection of muons with pseudorapidity −4<ημ<−2.5 and transverse momentum pμT>20 GeV/c in the laboratory frame. The invariant yield and nuclear modification factor are measured for opposite-sign dimuons with invariant mass 60<mμμ<120 GeVc2 and rapidity 2.5<yμμcms<4. They are presented as a function of rapidity and, for the Pb-Pb collisions, of centrality as well. The results are compared with theoretical calculations, both with and without nuclear modifications to the Parton Distribution Functions (PDFs). In p-Pb collisions the center-of-mass frame is boosted with respect to the laboratory frame, and the measurements cover the backward (−4.46<yμμcms<−2.96) and forward (2.03<yμμcms<3.53) rapidity regions. For the p-Pb collisions, the results are consistent within experimental and theoretical uncertainties with calculations that include both free-nucleon and nuclear-modified PDFs. For the Pb-Pb collisions, a 3.4σ deviation is seen in the integrated yield between the data and calculations based on the free-nucleon PDFs, while good agreement is found once nuclear modifications are considered.
Measurements of the production of muons from heavy-flavour hadron decays in Pb−Pb collisions at sNN−−−√ = 5.02 and 2.76 TeV using the ALICE detector at the LHC are reported. The nuclear modification factor RAA at sNN−−−√ = 5.02 TeV is measured at forward rapidity (2.5<y<4) as a function of transverse momentum pT in central, semi-central, and peripheral collisions over a wide pT interval, 3<pT<20 GeV/c, in which a significant contribution of muons from beauty-hadron decays is expected at high pT. With a significantly improved precision compared to the measurements at lower collision energy, the RAA shows an increase of the suppression of the yields of muons from heavy-flavour hadron decays with increasing centrality. A suppression by a factor of about three is observed in the 10% most central collisions. The RAA at sNN−−−√ = 5.02 is similar to that reported at 2.76 TeV in a broader pT interval and with an improved accuracy with respect to previously published measurements. The precise RAA results have the potential to distinguish between model predictions implementing different mechanisms of parton energy loss in the high-density medium formed in heavy-ion collisions. The results place stringent constraints on the relative energy loss between charm and beauty quarks.