Universitätspublikationen
Refine
Year of publication
- 2018 (1314) (remove)
Document Type
- Article (901)
- Doctoral Thesis (113)
- Working Paper (107)
- Preprint (78)
- Part of Periodical (40)
- Conference Proceeding (30)
- Part of a Book (21)
- Report (9)
- Review (9)
- Book (3)
Language
- English (1314) (remove)
Has Fulltext
- yes (1314)
Is part of the Bibliography
- no (1314)
Keywords
- Financial Institutions (9)
- breast cancer (9)
- inflammation (8)
- Neuroscience (7)
- Research article (7)
- Germany (6)
- Inflammation (6)
- Liquidity (6)
- Macro Finance (6)
- aging (6)
- Blood (5)
- Depression (5)
- Financial Markets (5)
- Heavy Ion Experiments (5)
- Mammakarzinom (5)
- Systemic Risk (5)
- cancer (5)
- mitochondria (5)
- Banking Union (4)
- Behandlung (4)
- Biomarker (4)
- Cell staining (4)
- Cirrhosis (4)
- Demography (4)
- ECB (4)
- Financial Stability (4)
- Hemorrhage (4)
- Household Finance (4)
- Neurons (4)
- Phosphorylation (4)
- Schizophrenia (4)
- Social System (4)
- Synapses (4)
- development (4)
- household finance (4)
- machine learning (4)
- metastasis (4)
- mutual information (4)
- pain (4)
- reactive oxygen species (4)
- regulation (4)
- Acinetobacter baumannii (3)
- Ascomycota (3)
- Axons (3)
- BESIII (3)
- Banking Regulation (3)
- Banking Supervision (3)
- Biodiversity (3)
- Biomarkers (3)
- Birds (3)
- Bitcoin (3)
- Breast cancer (3)
- CDK4/6 (3)
- Cancer (3)
- Cell membranes (3)
- Cognition (3)
- Community ecology (3)
- Competition (3)
- Cryptocurrency (3)
- Crystal structure (3)
- Developmental biology (3)
- EEG microstates (3)
- Exercise (3)
- Face (3)
- Flow cytometry (3)
- Fungi (3)
- Gene expression (3)
- German (3)
- HIV (3)
- Hepatocellular carcinoma (3)
- Invasive species (3)
- Liver diseases (3)
- Luciferase (3)
- Mental health and psychiatry (3)
- Metastasen (3)
- Morbidity (3)
- Neonates (3)
- Nerve fibers (3)
- OTC markets (3)
- Obesity (3)
- PD1/PDL1 (3)
- Palaeoclimate (3)
- Patients (3)
- Pension (3)
- Pension Insurance (3)
- Prognosis (3)
- Proteins (3)
- Quality of life (3)
- Questionnaires (3)
- Reaction time (3)
- School of Salamanca (3)
- Sensory processing (3)
- Small molecules (3)
- Sports (3)
- Stem cells (3)
- Studien (3)
- Teeth (3)
- Thailand (3)
- Vision (3)
- autophagy (3)
- chemotherapy (3)
- entropy (3)
- focused electron beam induced deposition (3)
- forensic entomology (3)
- glioblastoma (3)
- host specificity (3)
- information theory (3)
- macrophage (3)
- new taxa (3)
- rat (3)
- regeneration (3)
- regulatory arbitrage (3)
- reproducibility (3)
- risk (3)
- sphingolipids (3)
- treatment (3)
- ADHD (2)
- Acoustics (2)
- Action potentials (2)
- Alcohol consumption (2)
- Antarctica (2)
- Antiretroviral therapy (2)
- Anxiety (2)
- Atherosclerosis (2)
- Atrial fibrillation (2)
- Autism (2)
- Autism spectrum disorder (2)
- Autophagy (2)
- BRAF (2)
- Bacterial meningitis (2)
- Basidiomycetes (2)
- Basidiomycota (2)
- Behavior (2)
- Biohydrogen (2)
- Biophysical chemistry (2)
- Biosynthesis (2)
- Blood pressure (2)
- Brain metastasis (2)
- COPD (2)
- CTGF (2)
- Cancer treatment (2)
- Capital Markets Union (2)
- Cardiac magnetic resonance (2)
- Cardiovascular diseases (2)
- Cardiovascular magnetic resonance (2)
- Cell biology (2)
- Cell therapy (2)
- Central Clearing (2)
- Central Counterparties (2)
- Circuit Breaker (2)
- Citation analysis (2)
- Cognitive impairment (2)
- Collateral (2)
- Comparative genomics (2)
- Complex networks (2)
- Complications (2)
- Consensus (2)
- Cortisol (2)
- Counterparty Risk (2)
- Cryoelectron microscopy (2)
- Culture (2)
- Cytoskeleton (2)
- DNA (2)
- Data processing (2)
- Death rates (2)
- Decision making (2)
- Dendritic structure (2)
- Dentition (2)
- Derivatives (2)
- Diabetes (2)
- Diagnostic markers (2)
- Diagnostic medicine (2)
- Domestic animals (2)
- Dopamine (2)
- EMIR (2)
- EPR (2)
- Electroencephalography – EEG (2)
- Electronic properties and materials (2)
- Emotions (2)
- Endoplasmic reticulum (2)
- Etiology (2)
- Europe (2)
- European Supervisory Architecture (2)
- Eutheria (2)
- Evaluation (2)
- Everolimus (2)
- Extracellular matrix (2)
- Eye movements (2)
- Eyes (2)
- FGFR (2)
- Financial Literacy (2)
- Fistula (2)
- Formate dehydrogenase (2)
- GPCR (2)
- General practice (2)
- Genome-wide association studies (2)
- Geochemistry (2)
- German Banking System (2)
- Guidelines (2)
- HCC (2)
- HIV-1 (2)
- Heart (2)
- Hematology (2)
- High-throughput screening (2)
- Human behaviour (2)
- Hydrogen production (2)
- Hydrogenase (2)
- Immunology (2)
- Indoles (2)
- Insects (2)
- Internet (2)
- Kidney transplantation (2)
- Knees (2)
- Language (2)
- Legs (2)
- Liver fibrosis (2)
- Long non-coding RNAs (2)
- Loss Sharing (2)
- Magnetic properties and materials (2)
- Mammals (2)
- Margin (2)
- Markovianity (2)
- MaxEnt (2)
- Membrane potential (2)
- Membrane proteins (2)
- Metabolic syndrome (2)
- MicroRNAs (2)
- Migration (2)
- Mixed methods (2)
- Molecular medicine (2)
- Monetary Policy (2)
- Monte Carlo method (2)
- Morphometry (2)
- Mortality (2)
- Motor neurons (2)
- Multimorbidity (2)
- Multiple chronic conditions (2)
- Musculoskeletal system (2)
- Nephrons (2)
- Neural circuits (2)
- Neuronal dendrites (2)
- Next-generation sequencing (2)
- Nitric oxide (2)
- Non-small cell lung cancer (2)
- Oncology (2)
- Optogenetics (2)
- PCR (2)
- PELDOR (2)
- Palaeoceanography (2)
- Palliative care [MeSH] (2)
- Percutaneous coronary intervention (2)
- Periodontitis (2)
- Personality (2)
- Petrology (2)
- Phase transitions and critical phenomena (2)
- Polypharmacy (2)
- Primary care (2)
- Prostate cancer (2)
- Protein domains (2)
- Protein translation (2)
- Prävention (2)
- Psychological stress (2)
- Psychology (2)
- Pulmonary hypertension (2)
- Refugees (2)
- Risiko (2)
- Running (2)
- Scientists (2)
- Screening (2)
- Secretion (2)
- Senescence (2)
- Sensitivity (2)
- Sepsis (2)
- Sequence alignment (2)
- Sequence analysis (2)
- Simulation (2)
- Single-molecule biophysics (2)
- Solution-state NMR (2)
- Sports and exercise medicine (2)
- Stroke (2)
- Super-resolution microscopy (2)
- Surgical and invasive medical procedures (2)
- Surgical oncology (2)
- Survival (2)
- Sweden (2)
- Systematic Risk (2)
- Target validation (2)
- Transcription factors (2)
- Trauma (2)
- Treatment (2)
- Validation (2)
- Vesicles (2)
- Viral load (2)
- Vitamin D (2)
- Vitamin D deficiency (2)
- Volatility Interruption (2)
- acute kidney injury (2)
- adult neurogenesis (2)
- aggression (2)
- aminal structure (2)
- angiogenesis (2)
- antioxidants (2)
- ataxia telangiectasia (2)
- atherosclerosis (2)
- attention (2)
- authoritarianism (2)
- banking regulation (2)
- bioinformatics (2)
- blockchain (2)
- cardiac surgery (2)
- catheter ablation (2)
- cell migration (2)
- ceramides (2)
- child (2)
- chronic kidney disease (2)
- connectivity (2)
- conservation (2)
- correlation functions (2)
- cytokines (2)
- data science (2)
- database (2)
- democratic boundary problem (2)
- desiccation (2)
- diagnosis (2)
- education (2)
- endoplasmic reticulum (2)
- endothelial cells (2)
- epilepsy (2)
- exosomes (2)
- expectation formation (2)
- finance (2)
- financial stability (2)
- genetic markers (2)
- hedgehog signaling (2)
- hepatitis C virus (2)
- heterogeneity (2)
- hippocampus (2)
- human (2)
- hyperglycemia (2)
- hypoxia (2)
- imaging (2)
- immunotherapy (2)
- inclusion (2)
- innate immunity (2)
- interleukin-4 (2)
- liquidity (2)
- liver injury (2)
- lyme disease (2)
- mannitol (2)
- matrix (2)
- medical students (2)
- mesenchymal stromal/stem cells (2)
- metabolism (2)
- metastases (2)
- miRNA (2)
- microRNA (2)
- morphology (2)
- multidrug resistance (2)
- neocortical circuits (2)
- neurocognition (2)
- neuromodulation (2)
- next generation sequencing (NGS) (2)
- nitric oxide (2)
- obesity (2)
- paclitaxel (2)
- participation (2)
- personality (2)
- polarization (2)
- poverty (2)
- pregnancy (2)
- pressure (2)
- prevention (2)
- primary immunodeficiency (2)
- proteomics (2)
- psoriasis (2)
- radiation (2)
- rapamycin (2)
- refugees (2)
- reliability (2)
- resistance (2)
- rule (2)
- safety (2)
- schizophrenia (2)
- seasonality (2)
- seizure (2)
- semantics (2)
- sensory neurons (2)
- signaling (2)
- skin (2)
- smut fungi (2)
- sphingosine 1-phosphate (2)
- spreadsheet (2)
- stationarity (2)
- statistical operator (2)
- supervisory arbitrage (2)
- synaptic plasticity (2)
- tobacco prevention (2)
- transport coefficients (2)
- trauma (2)
- trehalose (2)
- trials (2)
- unconventional monetary policy (2)
- vaccine (2)
- validity (2)
- valley winds (2)
- vascular endothelial cells (2)
- vector (2)
- vemurafenib (2)
- videos (2)
- volatile organic compounds (2)
- wine (2)
- workflow (2)
- (surface) partial differential equations (1)
- *ABA (1)
- 1,2-dichloroethane (1)
- 1,25-Dihydroxyvitamin D (1)
- 1-octanol (1)
- 16p11.2 (1)
- 2-deoxyglucose (2-DG) (1)
- 3,30′-ethane-1,2-diyl-bis-1,3,5-triazabicyclo[3.2.1]octane (1)
- 3C protease(3Cpro) (1)
- 3D modeling (1)
- 3D spatio-temporal resolved mathematical models (1)
- 4-FA (1)
- 401(k) plan (1)
- 5-Lipoxygenase activating protein (FLAP) (1)
- 5-lipoxygenase (1)
- A375 human melanoma cells (1)
- A549 (1)
- ABC proteins (1)
- ABC transporter (1)
- ABCE1 (1)
- ACE-inhibitor (1)
- ACL rupture (1)
- ACURATE neo (1)
- ADP (1)
- AEC syndrome (1)
- AIDS (1)
- AKI (1)
- ALK gene (1)
- ALK-rearranged NSCLC (1)
- AML (1)
- ANOSIM (1)
- APP processing (1)
- ARA (1)
- ARMA (1)
- ASO (1)
- ATP (1)
- ATP-citrate lyase (1)
- ATPase (1)
- ATPases (1)
- Abatacept (1)
- Absolute branching fraction (1)
- Accreting black holes (1)
- Acetobacterium woodii (1)
- Activin (1)
- Activities of daily living (1)
- Acupuncture (1)
- Acute bronchitis (1)
- Acute cough (1)
- Acute lymphocytic leukaemia (1)
- Acute myeloid leukemia (1)
- Adenylyl cyclase (1)
- Adipose-derived mesenchymal stem cells (1)
- Adolescents (1)
- Adult-onset ADHD (1)
- Adults (1)
- Adverse Selection (1)
- Aedes aegypti (1)
- Aedes albopictus (1)
- AfD (1)
- Afghanistan (1)
- Afrotheria (1)
- Agaricales (1)
- Age (1)
- Age groups (1)
- Age-structure (1)
- Aggregate outcomes (1)
- Aggressive periodontitis (1)
- Agriculture (1)
- Akaike information criterion (1)
- Akaike information criterion (AIC) (1)
- Ala-5 (1)
- Alcanivorax borkumensis SK2 (1)
- Alcohols (1)
- Alexandrian commentaries (1)
- Aliphatic halogenated hydrocarbons (1)
- Alleles (1)
- Allergic asthma (1)
- Allosteric inhibition (1)
- Alternative splicing (1)
- Alveolar ridge augmentation (1)
- Alzheimer’s disease (1)
- Ambroxol (1)
- American crocodile (1)
- Amyloid-beta (1)
- Anamorphic fungi (1)
- Anchoring (1)
- Andexanet alpha (1)
- Angioedema (1)
- Angiogenesis (1)
- Angioplasty (1)
- Animal behavior (1)
- Animal flight (1)
- Animal navigation (1)
- Animal phylogenetics (1)
- Animal sociality (1)
- Animal wings (1)
- Anisakid nematodes (1)
- Annihilation (1)
- Annual density fluctuation (1)
- Anonymity Services (1)
- Anti de Sitter space (1)
- Anti-viral activity (1)
- Antibiotics (1)
- Antibodies (1)
- Antibody-mediated rejection (1)
- Anticancer therapy (1)
- Anticoagulant therapy (1)
- Anticonvulsant activity (1)
- Antioxidants (1)
- Antiretrovirals (1)
- Antirheumatic agents (1)
- Antithrombotic therapy (1)
- Antiviral agents (1)
- Antiviral therapy (1)
- Ants (1)
- Anxiety disorders (1)
- Apical Vesicular Transport (1)
- Apixaban (1)
- Apoptosis (1)
- Aquaporins (1)
- Arabic-Islamic authors (1)
- Arabidopsis (1)
- Arabidopsis thaliana (1)
- Arabinogalactan-proteins (1)
- Arachidonic acid cascade (1)
- Arbitrage (1)
- Areas of Interest (1)
- Arendt, Hannah (1)
- Aristotle (1)
- Aristòtil (1)
- Aristóteles (1)
- Arms (1)
- Art (1)
- Ascites (1)
- Aspergillus (1)
- Aspergillus nidulans (1)
- Asphyxia (1)
- Asset Liquidation (1)
- Asset Pricing (1)
- Atakora mountain chain (1)
- Atrial appendage occlusion (1)
- Attention (1)
- Attention-deficit / hyperactivity disorder (1)
- Attentional set (1)
- Attitude (1)
- Auction (1)
- Audit fees (1)
- Audit partner tenure (1)
- Audit quality (1)
- Auditing (1)
- Auditor rotation (1)
- Aurora A (1)
- Aurora kinase (1)
- Australia (1)
- Austria (1)
- Autism Spectrum Disorder (1)
- Auto transfusion (1)
- Autoimmune response (1)
- Autoimmunity (1)
- Autopsy (1)
- Azan (1)
- Azathioprine (1)
- B cell subpopulations (1)
- B cells (1)
- B-cell immunology (1)
- B-cell lymphoma (1)
- BATF3 (1)
- BCR signaling (1)
- BIAM-switch (1)
- BMC (1)
- BMR (1)
- BPD (1)
- BRCA1 (1)
- BRCA2 (1)
- BTK (1)
- Babesia divergens (1)
- Babesia microti (1)
- Bacterial pathogens (1)
- Bacteriophages (1)
- Bank of Japan (1)
- Bank regulation (1)
- Banking union (1)
- Bargaining (1)
- Bartolomé de Las Casas (1)
- Batten disease (1)
- Bayes (1)
- Bayesian analysis (1)
- Bayesian estimation (1)
- Bayesian inference (1)
- Bayesian information criterion (1)
- Bayesian learning (1)
- Behavioral analysis (1)
- Behavioral ecology (1)
- Benefit (1)
- Bertolt Brecht (1)
- Best practice (1)
- Beta-diversity (1)
- Bias (1)
- Bibliometrics (1)
- Bidirectional genes (1)
- Big five (1)
- Binding analysis (1)
- Binoculars (1)
- BioEn (1)
- Biochemistry (1)
- Biochemistry and chemical biology (1)
- Bioenergetics (1)
- Biofluids (1)
- Biofuel (1)
- Biogeochemistry (1)
- Biogeography (1)
- Bioinformatics (1)
- Biological (1)
- Biological citizenship (1)
- Biological invasion (1)
- Biomechanical analysis (1)
- Biophysical models (1)
- Biophysics (1)
- Biopsy (1)
- Biosynthetic mesh (1)
- Biotin (1)
- Bipolar disorder (1)
- Bird flight (1)
- Bird physiology (1)
- Birds of prey (1)
- Birth weight (1)
- Black hole (1)
- Black holes (1)
- Blasphemy Law (1)
- Blended learning (1)
- Blockchain (1)
- Blood cells (1)
- Blood groups (1)
- Blood-brain barrier (1)
- Bloodstream infections (1)
- Blurred vision (1)
- Bolhmann bands (1)
- Bone defect (1)
- Bone marrow cells (1)
- Bone marrow fibrosis (1)
- Bone marrow mononuclear cells (1)
- Bone marrow-derived mesenchymal stem cells (1)
- Bone tissue engineering (1)
- Borderline personality disorder (1)
- Borrelia (1)
- Borrelia burgdorferi (1)
- Borrelia miyamotoi (1)
- Bosnia and Herzegovina (1)
- Bourdieu, Pierre (1)
- Bradykinin (1)
- Brain DNA methylation (1)
- Brain anatomy (1)
- Brain damage (1)
- Brain ischemia (1)
- Branching fractions (1)
- Breast tumors (1)
- Brexit (1)
- Bridge International (1)
- Bright light therapy (1)
- Broker Crossing Networks (1)
- Bronchial inflammation (1)
- Bronchitis severity scale (1)
- Bronchopulmonary dysplasia (1)
- Brownian motion (1)
- Brush Border Formation (1)
- Brustkrebs (1)
- Burden of disease (1)
- Business lending (1)
- Bypass liner (1)
- C-reactive protein (1)
- C. elegans (1)
- C1 inhibitor (1)
- C1-inhibitor (1)
- C5 acylcarnitine (1)
- CABLE (1)
- CCL2 (1)
- CCN2 (1)
- CD3/19 depletion (1)
- CD34 selection (1)
- CD36 (1)
- CD74 (1)
- CDK4/6 inhibitor (1)
- CEP68 (1)
- CHRNA10 (1)
- CHRNA7 (1)
- CHRNA9 (1)
- CLN3 (1)
- CLOUD experiment (1)
- CNS (1)
- CNS infection (1)
- CNS melanoma (1)
- CNV 16p11.2 (1)
- CO2 reduction (1)
- CO2-induced forced ventilation (1)
- COI (1)
- COII (1)
- COMT (1)
- COPD assessment test (1)
- COPD course and therapy (1)
- COSMO-CLM (1)
- CRE-luciferase (1)
- CRISPR/Cas9 (1)
- CRM1 (1)
- CTX (1)
- Ca2+ imaging (1)
- Caddisfly (1)
- Caenorhabditis elegans (1)
- Caffeine (1)
- Calcium signalling (1)
- Calcium waves (1)
- Calliphora (1)
- Calnexin (1)
- Cameroon (1)
- Canada (1)
- Canary Current (1)
- Canary Islands (1)
- Cancer cell migration (1)
- Cancer detection and diagnosis (1)
- Cancer development (1)
- Cancer epidemiology (1)
- Cancer genomics (1)
- Cancer progression (1)
- Cancer therapy (1)
- Canonical suppression (1)
- Caprylic acid (1)
- Carbohydrate active enzymes (1)
- Carbon capture (1)
- Carbon tetrachloride (1)
- Carboxylic acid reductase (1)
- Cardiac Fibrosis (1)
- Cardiac surgery (1)
- Cardiac surgery patients (1)
- Cardiomyopathy (1)
- Cardiovascular biology (1)
- Cardiovascular disease (1)
- Cardiovascular genetics (1)
- Cell adhesion (1)
- Cell binding (1)
- Cell cultures (1)
- Cell distribution (1)
- Cell salvage (1)
- Cell signalling (1)
- Cell-free Protein Synthesis (1)
- Cell-free protein synthesis (1)
- Cementation (1)
- Central Counterparty Clearing House (CCP) (1)
- Ceramic (1)
- Cerclage (1)
- Cerebral ischemia (1)
- Cerebrospinal fluid (1)
- Cerrado (1)
- Certification (1)
- Cesarean section (1)
- Chaenodraco wilsoni (1)
- Champsocephalus gunnari (1)
- Channichthyidae (1)
- Chaperone (1)
- Charged-particle multiplicity (1)
- Charmonium (1)
- Chemical biology (1)
- Chemical ecology (1)
- Chemnitz (1)
- Chemobrain (1)
- Chemoembolization (1)
- Chemoinformatics (1)
- Chemoprevention (1)
- Chest pain unit (1)
- Chikungunya virus (1)
- Child (1)
- Children (1)
- Children’s agency (1)
- Chironomidae (1)
- Chlorides (1)
- Chloroform (1)
- Chondrocytes (1)
- Chorismate mutase-prephenate dehydratase (1)
- Chromatin accessibility (1)
- Chromatin and Epigenetics (1)
- Chromosomes and gene expression (1)
- Chronic heart failure (1)
- Chronic periodontiti (1)
- Chronification (1)
- Chrysomya chani (1)
- Chrysomya megacephala (1)
- Church (1)
- Circadian rhythms and sleep (1)
- Circumplex Scales of Intergroup Goals (1)
- Ciudadanía (1)
- Civil and political rights (1)
- Classroom Management (1)
- Cleanliness level (1)
- Clearing (1)
- Climate (1)
- Climate Change (1)
- Climate sciences (1)
- Clinical frailty scale (1)
- Clinical genetics (1)
- Clinical outcome (1)
- Clinical psychometry (1)
- Clinical study (1)
- Clinical trials (1)
- Closure (1)
- Co-culture (1)
- Co-morbidity (1)
- CoCo bonds (1)
- Cocaine (1)
- Coevolution (1)
- Cognitive Load (1)
- Cognitive control (1)
- Cognitive neuroscience (1)
- Cognitive psychology (1)
- Collaboration (1)
- Collagens (1)
- Colon cancer (1)
- Colon capsule endoscopy (1)
- Color superconductivity (1)
- Comorbidity (1)
- Compact stars (1)
- Comparative effectiveness research (1)
- Compartmentalization (1)
- Complement system (1)
- Complementation rate (1)
- Complete heart block (1)
- Complex I (1)
- Complex II (1)
- Complex hernia (1)
- Complex problem solving (1)
- Complication management (1)
- Computational biology (1)
- Computational chemistry (1)
- Computational models (1)
- Computer-based assessment (1)
- Confirmatory Bias (1)
- Conformal Field Theory (1)
- Conformational trapping (1)
- Connective tissue (1)
- Connectomics (1)
- Consolidation (1)
- Consortia (1)
- Constitutional Reform (1)
- Consumer financial protection (1)
- Consumption (1)
- Contact microradiography (1)
- Contact network (1)
- Contracaecum (1)
- Contract terms (1)
- Convection (1)
- Conventional synthetic disease-modifying antirheumatic drug (1)
- Coronary artery disease (1)
- Coronary intervention (1)
- Corporate Bonds (1)
- Corporate Finance (1)
- Cortex (1)
- Cre-lox system (1)
- Credentialing (1)
- Credit Default Swap (CDS) (1)
- Credit Risk (1)
- Credit lines (1)
- Credit rating agencies (1)
- Criterio A (1)
- Criterion A (1)
- Critical bleeding (1)
- Crocodylus acutus (1)
- Crohn’s disease (1)
- Cryptic species (1)
- Cryptocurrencies (1)
- CspZ (1)
- Cultural diversity of law (1)
- Cuneiform (1)
- Cyclic GMP (1)
- Cyprus (1)
- Cystic fibrosis (1)
- Cytokines (1)
- Cytology (1)
- Czochralski method (1)
- DAA (1)
- DAMP (1)
- DEER (1)
- DLBCL (1)
- DMARDs (biologic) (1)
- DMARDs (synthetic) (1)
- DNA methylation (1)
- DNA mismatch repair (1)
- DNA transporter (1)
- DNA-based taxonomy (1)
- DNase1-seq (1)
- DOK1 (1)
- DSGE models (1)
- DSM (1)
- DTI (1)
- Dabigatran (1)
- Daily flight activity (1)
- Dalitz decay (1)
- Dark Pools (1)
- Data acquisition (1)
- Data management (1)
- Data science (1)
- Data visualization (1)
- Decision Confidence (1)
- Deformation (1)
- Delta resonance (1)
- Democracy (1)
- Demos (1)
- Dengue (1)
- Dengue fever (1)
- Dengue virus (1)
- Dense matter (1)
- Density equalizing mapping (1)
- Dental implants (1)
- Dental phobia (1)
- Dental training (1)
- Dentin (1)
- Depolarization (1)
- Derivate (1)
- Dermatomyositis (1)
- Deutschland (1)
- Developmental biology and stem cells (1)
- Developmental programming (1)
- Developmental trajectory (1)
- Di-hadron correlations (1)
- DiD (1)
- Diabetes mellitus (1)
- Diagnose (1)
- Diagnosis (1)
- Diagnostik (1)
- Dichloromethane (1)
- Dietary HDAC inhibitor (1)
- Differential equations (1)
- Differentiation (1)
- Diflapolin (1)
- Digital rectal examination (1)
- Dimer (1)
- Dimers (Chemical physics) (1)
- Direct current electrical stimulation (1)
- Direct reactions (1)
- Disc herniation (1)
- Disease Modeling (1)
- Dispositional learning analytics (1)
- Dissociative seizures (1)
- Distance to water (1)
- Distributed Ledger (1)
- Diversidad (1)
- Dodd-Frank Act (1)
- Dominated States (1)
- Donor Selection (1)
- Dothideomycetes (1)
- Drosophila melanogaster (1)
- Drug discovery (1)
- Drug interactions (1)
- Drug safety (1)
- Drug therapy (1)
- Drug-Drug Interactions (1)
- Dual therapy (1)
- Dynamic networks (1)
- Dynamic stochastic general equilibrium model (1)
- D⁰ meson (1)
- E-Learning (1)
- E. coli (1)
- E. colo (1)
- E/I-Balance (1)
- EEG (1)
- EEG-TMS (1)
- EGFL7 (1)
- EMT (1)
- ENCODE-DREAM in vivo Transcription Factor binding site prediction challenge (1)
- ERMS (1)
- EROS (1)
- EU (1)
- EU countries (1)
- Early (prenatal and postnatal) life experiences (1)
- Early diagnosis (1)
- Early recurrence (1)
- Eastern boundary upwelling ecosystem (1)
- Ebola virus (1)
- Ecological metrics (1)
- Ecological networks (1)
- Ecological niche modeling (1)
- Ecology (1)
- Economic history (1)
- Economy (1)
- Ecosystem ecology (1)
- Ecosystems (1)
- Ectoparasites (1)
- Edoxaban (1)
- Educación (1)
- Eigentum (1)
- Elderly (1)
- Elective caesarean section (1)
- Elephants (1)
- Elevation (1)
- Ellipsoids (1)
- Eltonian noise hypothesis (1)
- Emotional recognition (1)
- EnKS 3D (1)
- Endocrine cancer (1)
- Endogenous heat load (1)
- Endoscopy (1)
- Endothelial cells (1)
- Endothelium (1)
- Energy (1)
- Energy system analysis (1)
- Energy system modelling tool (1)
- Enforcement (1)
- England (1)
- Ensemble learning (1)
- Enterostomy (1)
- Enterostomy closure (1)
- Enterostomy formation (1)
- Enterovirus 71 (1)
- Entrepreneurship (1)
- Entry and exit (1)
- Entyloma microsporum complex (1)
- Entyloma ranunculi-repentis complex (1)
- Env (1)
- Environment (1)
- Environmental chemistry (1)
- Environmental enrichment (1)
- Enzyme kinetics (1)
- Enzyme mechanisms (1)
- Epidemic (1)
- Epidemiology (1)
- Epidermal growth factor receptor (1)
- Epidural block (1)
- Epigenetics (1)
- Epilepsy (1)
- Epileptic seizures (1)
- Epistles of the Sincere Brethren (1)
- Epithelial cells (1)
- Epstein-Barr virus (1)
- Epstein–Barr virus (1)
- Epístolas de los Hermanos de la Pureza (1)
- Epístoles dels Germans de la Puresa (1)
- Equation of state (1)
- Equidad (1)
- Equipment (1)
- Ergonomics (1)
- Erkenntnistheorie (1)
- Esters (1)
- Estradiol (1)
- Eukaryota (1)
- Euro (1)
- European Market Infrastructure Regulation (EMIR) (1)
- European Portuguese (1)
- European Union (1)
- European banks (1)
- European registry for idiopathic pulmonary fibrosis (eurIPFreg) (1)
- Europeanization (1)
- Evidence-based policymaking (1)
- Evolution (1)
- Evolutionary ecology (1)
- Examination questions (1)
- Exchange Format (1)
- Executive function (1)
- Exercise identity (1)
- Exercise self-schema (1)
- Exosomes (1)
- Expected Returns (1)
- Experimental models of disease (1)
- Extending Discourses (1)
- Extinction (1)
- Extracellular matrix proteins (1)
- Extracorporeal purification (1)
- F1Fo-ATP-synthase (1)
- FAM134B (1)
- FDI-intensity (1)
- FOXO3a (1)
- FRET imaging (1)
- FTY720 (1)
- FX06 (1)
- Face recognition (1)
- Factor analysis (1)
- Fascia (1)
- Fats (1)
- Fatty acid synthase (1)
- Fatty alcohol (1)
- Fear conditioning (1)
- Feather mites (1)
- Federal Reserve (1)
- Fenofibrate (1)
- Ferroptosis (1)
- Fiber Bundles (1)
- Fibroblasts (1)
- Fibrosis (1)
- Fibrous dysplasia (1)
- Ficus carica (1)
- Financial Crises (1)
- Financial Education (1)
- Financial Regulation (1)
- Financial frictions (1)
- Financial intermediation (1)
- Financial regulation (1)
- Finanzmärkte (1)
- Finanzwirtschaft (1)
- Finite Element Method (1)
- Finite Volumes (1)
- Fiscal stress (1)
- Fish (1)
- Fisher information (1)
- Flaps (1)
- Flash Crash (1)
- Flight-to-safety (1)
- Flowers (1)
- Fluid dynamics (1)
- Fluorene derivatives (1)
- Fluorescent proteins (1)
- Foam rolling (1)
- Food-web (1)
- Foraging (1)
- Foreign Investment Insurance (1)
- Forensic science (1)
- Forensics (1)
- Forest resources (1)
- Formation dance (1)
- Formative assessment (1)
- Fourier analysis (1)
- Fragmentation (1)
- Frailty (1)
- Fraud (1)
- Free energy (1)
- Freshwater ecology (1)
- Fruit body (1)
- Früherkennung (1)
- Frühgeburt (1)
- Fulani (1)
- Functional clustering (1)
- Functional genomics (1)
- Fungal genetics (1)
- Fungal spores (1)
- Fusarium (1)
- G-protein coupled receptor (1)
- G2A (1)
- GABA (1)
- GABAergic interneurons (1)
- GDPR (1)
- GI pH (1)
- GI solubility (1)
- GLI inhibitors (1)
- GMYC (1)
- GPS collar (1)
- GRACE (1)
- GSK3α (1)
- GSK3β (1)
- Galaktografie (1)
- Galaktomosynthese (1)
- Games (1)
- Gamma distribution (1)
- Gamma-Band Activity (1)
- Gap junctions (1)
- Gas chromatography-mass spectrometry (1)
- Gastric cancer (1)
- Gastrointestinal cancer (1)
- Gastrointestinal tract (1)
- Gauge-gravity correspondence (1)
- Gender (1)
- Gender gap (1)
- Gene Regulation (1)
- Gene expression profiling (1)
- Gene flow (1)
- Gene fusion (1)
- Gene microarray analysis (1)
- Gene regulation (1)
- Gene therapy (1)
- General Data Protection Regulation (1)
- General Equilibrium (1)
- General dental practice (1)
- General relativity (1)
- Generation time (1)
- Genetic engineering (1)
- Genetic transduction (1)
- Genetics (1)
- Genotyping (1)
- Geodesics (1)
- Geographically weighted regression (GWR) (1)
- Geomorphology (1)
- German Agribusiness (1)
- German Reunification (1)
- German people (1)
- German reunification (1)
- Germany Inc. (1)
- Gestational age (1)
- Gig-economy (1)
- Gini (1)
- Glaucoma (1)
- Glioblastoma (1)
- Global Governance (1)
- Global Justice (1)
- Global South (1)
- Global ethnography (1)
- Globalisierung (1)
- Globalization (1)
- Glomerulus (1)
- Glomosporiaceae (1)
- Glycosphingolipids (1)
- Golgi (1)
- Government spending multiplier (1)
- Grafts (1)
- Gram negative bacteria (1)
- Granger Causality (1)
- Graph theory (1)
- Gravity self-completeness (1)
- Great philippine eagle (1)
- Greater tuberosity fractures (1)
- Greeks (1)
- Growth factors (1)
- Guanine nucleotide exchange factors (1)
- Guanosine triphosphatase (1)
- Guided waves (1)
- HACA (1)
- HBV reactivation (1)
- HCV treatment (1)
- HER2 c-erbB2 (1)
- HER2-positive (1)
- HER2/neu (1)
- HH (1)
- HIV serodiagnosis (1)
- HLA class II (1)
- HLA peptidome (1)
- HMGB1 (1)
- HPV (1)
- HRas (1)
- HWC database (1)
- Hadronic decays (1)
- Haematoma expansion (1)
- Haemostatics (1)
- Hannah Arendt (1)
- Hantavirus (1)
- Hashimoto’s thyroiditis (1)
- Hawking radiation (1)
- Head injury (1)
- Health care resource utilization (1)
- Health economics (1)
- Health education (1)
- Health information (1)
- Health risk analysis (1)
- Health-seeking behaviour (1)
- Heart rate (1)
- Heart transplantation (1)
- Heavy-ion collision (1)
- Heavy-ion collisions (1)
- Hedgehog pathway (1)
- Helpline (1)
- Hematocrit value (1)
- Hematopoietic stem cell transplantation (1)
- Hemodynamics (1)
- Hengduan Mountains (1)
- HepG2 (1)
- Hepatitis B virus (1)
- Hepatitis C virus (1)
- Hepatitis C, Chronic (1)
- Herbalife (1)
- Hereditary breast and ovarian cancer (1)
- Heston model (1)
- HhAntag (1)
- Hidden Markov Model (1)
- High performance liquid chromatography (1)
- High-Frequency Trading (1)
- High-intensity interval endurance training (1)
- High-resolution (1)
- Himalaya (1)
- Hindu Kush Himalayas (1)
- Hinduismus (1)
- Hip (1)
- Hippocampus (1)
- Hispaniola (1)
- Histology (1)
- Histone post-translational modifications (1)
- History of individual rights (1)
- Hochschule (1)
- Home ownership (1)
- Homeostasis (1)
- Homing behavior (1)
- Hominins (1)
- Homo erectus (1)
- Homology (1)
- Honey bees (1)
- Horner's syndrome (1)
- Horses (1)
- Household finance (1)
- Housing tenure (1)
- HuR (1)
- Human prostate (1)
- Hydrogen bonding (1)
- Hydrogen storage (1)
- Hydrogen-dependent CO2 reductase (1)
- Hydroxychloroquine (1)
- Hydroxycut (1)
- Hydroxymandelate synthase (1)
- Hydroxyurea (1)
- Hyperons (1)
- Hypertext (1)
- Hypoxia inducible factor (1)
- Hyraxes (1)
- ICN (1)
- ICT4D (1)
- IFN (1)
- IFRS (1)
- IL-18BP (1)
- IL-1β (1)
- IL-6 (1)
- ILT (1)
- IRES translation (1)
- ISIS (1)
- ITGA7 (1)
- IUIPC (1)
- IVA interference tandem mass spectrometry (1)
- Iceland (1)
- Iconography (1)
- Idarucizumab (1)
- Idiopathic pulmonary fibrosis (IPF) (1)
- Idiosyncratic Risk (1)
- Idiosyncratic volatility puzzle (1)
- Image processing (1)
- Imaging (1)
- Imaging in LGG (1)
- Immune suppression (1)
- Immunosenescence (1)
- Immunotherapy (1)
- Implementation (1)
- In vitro selection (1)
- In-work poverty (1)
- Incisional hernia (1)
- Inclusión (1)
- Incomplete colonoscopy (1)
- Indian culture (1)
- Indirect-binding (1)
- Individual rights (1)
- Induced sputum (1)
- Inequality (1)
- Infectious disease epidemiology (1)
- Inflammatory diseases (1)
- Inflammatory pain (1)
- Inflation (1)
- Informatik (1)
- Information theory and computation (1)
- Informationsverarbeitung (1)
- Infrastructure (1)
- Injection therapy (1)
- Injuries (1)
- Injury (1)
- Innate immune system (1)
- Institutional investors (1)
- Instructional Strategy (1)
- Insulin (1)
- Insurance Companies (1)
- Insurance Markets (1)
- Integrins (1)
- Intensive care outcome (1)
- Intensive care units (1)
- Interconnectedness (1)
- Interest Rates (1)
- Interference fragmentation function (1)
- Interleukin-6 (1)
- Intermediated work (1)
- Internal ribosome entry site (1)
- Internet Governance (1)
- Internet Users’ Information Privacy Concerns (1)
- Internet of Things (1)
- Interpersonal relationships (1)
- Interspecific competition (1)
- Interstitial lung diseases (ILD) (1)
- Intervertebral disc degeneration (1)
- Intra-abdominal infection (1)
- Intracellular pathogens (1)
- Intracerebral haemorrhage (1)
- Intracerebroventricular (1)
- Intracranial haemorrhage (1)
- Intracranial hemorrhage (1)
- Intragastric balloon (1)
- Inverse Kinematics (1)
- Invertebrates (1)
- Investment Protection (1)
- Investor Protection (1)
- Investor protection (1)
- Ion source (1)
- Ion transport (1)
- Irregular vaccination (1)
- Italy (1)
- Ivor Lewis esophagectomy (1)
- J-couplings (1)
- JNK3 (1)
- Jaw (1)
- John Rawls (1)
- Juan de Palacios Rubios (1)
- Jumping (1)
- KAP (1)
- KDIGO (1)
- Kaisidis plate (1)
- Karen Horney (1)
- Kidney (1)
- Kidney Transplantation (1)
- Kidney transplant recipients (1)
- Kinase inhibitors (1)
- Klasse (1)
- Klassenführung (1)
- Klebsiella oxytoca (1)
- Knowledge (1)
- Kollaboration <Informatik> (1)
- Kontrahentenrisiko (1)
- Krebsforschung (1)
- Kupffer cells (1)
- Kynurenine (1)
- L1 attrition (1)
- LCH (1)
- LILBID (1)
- Labor and delivery (1)
- Lactic acidosis (1)
- Langerhans cell histiocytosis (1)
- Laparostomy (1)
- Larvae (1)
- Lasers (1)
- Laterality (1)
- Latin America (1)
- Lattice QCD (1)
- Lattice field theory (1)
- Leaf clearing (1)
- Learning (1)
- Learning Analytics (1)
- Learning analytics (1)
- Learning dispositions (1)
- Lectin affinity plasmapheresis (1)
- Lectures (1)
- Leflunomide (1)
- Legal History (1)
- Legal pluralism (1)
- Lehre (1)
- Lesions (1)
- Leukocyte elastase (1)
- Liability regime (1)
- LibGen (1)
- Library screening (1)
- Life Insurance (1)
- Light (1)
- Light nuclei production (1)
- Light pulses (1)
- Light sheet fluorescence microscopy (1)
- Light sheet-based fluorescence microscopy (1)
- Light-sheet microscopy (1)
- Linear regression analysis (1)
- Lipid Environment (1)
- Lipid-based formulation (1)
- Lipidol (1)
- Lipopolysaccharide-binding protein (1)
- Liquidity Provision (1)
- Liquidity provider incentives (1)
- Liver cirrhosis (1)
- Liver transplantation (1)
- Livestock (1)
- LncRNA (1)
- Load flow calculations (1)
- Loan Losses (1)
- Local climate (1)
- Local control (1)
- Locomotor circuit (1)
- Log data (1)
- Lokalrezidiv (1)
- Long ncRNA (1)
- Long-term live imaging (1)
- Lottery stocks (1)
- Low volume prep (1)
- Low-grade glioma (1)
- Lucas paradox (1)
- Lumbar spine (1)
- Lung adenocarcinoma (1)
- Lyapunov exponents (1)
- Lysosome (1)
- MALDI MS (1)
- MDR1 (1)
- MEIS2 (1)
- MET (1)
- MOLLI (1)
- MR spectroscopy (1)
- MR-proADM (1)
- MRI (1)
- MRP4 (1)
- MRT (1)
- Machine learning (1)
- Macrophages (1)
- Macrophysiology (1)
- Madagascar (1)
- Main olfactory epithelium (1)
- Malaria (1)
- Malawi Rift (1)
- Mamma (1)
- Mammalian genomics (1)
- Mammalian target of rapamycin (1)
- Mandelic acid (1)
- Marburg virus (1)
- Marine chemistry (1)
- Market Design (1)
- Market Fragility (1)
- Market Fragmentation (1)
- Market fragmentation (1)
- Market manipulation (1)
- Marsupials (1)
- Mass spectra (1)
- Maternal morbidity (1)
- Maternal separation (1)
- Maxillary sinus (1)
- Mc Kean martingale (1)
- MdfA (1)
- Medical communication (1)
- Medical education (1)
- Medical ethics (1)
- Medical hypoxia (1)
- Medical imaging (1)
- Medical risk factors (1)
- Medical traineeship (1)
- Medication Appropriateness Index (1)
- Medication changes (1)
- Melanocortin (1)
- Membrane Proteins (1)
- Membrane protein (1)
- Membrane staining (1)
- Mental health therapies (1)
- Mesangial cells (1)
- Mesh (1)
- Mesh repair (1)
- Messenger RNA (1)
- Meta effect (1)
- Metaanalysis (1)
- Metabolic critical temperatures (1)
- Metabolomics (1)
- Metacognition (1)
- Metalloproteins (1)
- Meteorology (1)
- Methotrexate (1)
- Methylation (1)
- MiFID II (1)
- MiFIR (1)
- Micro CT (1)
- Micro RNAs (1)
- Micro-CT (1)
- Microalgae (1)
- Microbial ecology (1)
- Microbial mutation (1)
- Microbiome (1)
- Microsatellite instability (1)
- Microvillus Atrophy (1)
- Middle East respiratory syndrome coronavirus (1)
- Midline laparotomy (1)
- Mindanao hawk-eagle (1)
- Minimal Important Difference (MID) (1)
- Minimal core of imaging (1)
- Minimal invasive (1)
- Mitochondria (1)
- Mitochondrial ROS (1)
- Mitochondrial disorder (1)
- Mitochondrial dysfunction (1)
- Mitochondrial proteins (1)
- Mitochondrial respiration (1)
- Mitophagy (1)
- MitraClip (1)
- Model Organism (1)
- Model complexity (1)
- Model evaluation (1)
- Model-based public policy (1)
- Modelling (1)
- Models of QCD (1)
- Modernity (1)
- Modified gravity (1)
- Molars (1)
- Molecular association (1)
- Molecular conformation (1)
- Molecular docking (1)
- Molecular genetics (1)
- Molecular modelling (1)
- Molecular phylogeny (1)
- Monetary Union (1)
- Monetary policy transmission (1)
- Mongolia (1)
- Monocytes and macrophages (1)
- Monolithic crown (1)
- Mooney faces (1)
- Moraceae (1)
- Morphogenesis (1)
- Motherhood (1)
- Motor skills (1)
- Mott metal-insulator transition (1)
- Mott transition (1)
- Mountain (1)
- Mouse (1)
- Mouse model (1)
- Mouse models (1)
- Moviprep (1)
- Multi-level marketing (1)
- Multi-modal feedback (1)
- Multi-normativity (1)
- Multidimensional Recurrence Quantification Analysis (1)
- Multidimensional Time series (1)
- Multidisciplinary management (1)
- Multidrug resistance (1)
- Multimodal treatment (1)
- Multiple parton interactions (1)
- Multiple sclerosis (1)
- Multivariate analysis (1)
- Muscle contraction (1)
- Muscle electrophysiology (1)
- Muscle fibers (1)
- Muscle tissue (1)
- Musculoskeletal injury (1)
- Mushroom (1)
- Music perception (1)
- Musician-specific seating position (1)
- Mutant p53 (1)
- Myalgia (1)
- Mycobacterium tuberculosis (1)
- Myelofibrosis (1)
- Myocardial infarction (1)
- Myocardial revascularization (1)
- Myofascial pain (1)
- Mössbauer spectroscopy (1)
- N-Acetylaspartate (1)
- N-acetylcysteine (1)
- N-methyl-D-aspartate receptor (1)
- NADH:ubiquinone oxidoreductase (1)
- NAFLD (1)
- NASH (1)
- NBO analysis (1)
- NDNF interneurons (1)
- NDUFA6 (1)
- NK cells (1)
- NKG2A blocking (1)
- NKG2D (1)
- NK cells (1)
- NMR (1)
- NMR Spectroscopy (1)
- NMR spectroscopy (1)
- NO-GC stimulators (1)
- NOD2 (1)
- NSTEMI (1)
- Nachsorge (1)
- Nano-ESI MS (1)
- Nanobody (1)
- Nanodiscs (1)
- Nanoparticles (1)
- Nanoscale materials (1)
- Native mass spectrometry (1)
- Natriuretic peptide (1)
- Natural Language Processing (1)
- Natural Products (1)
- Natural products (1)
- Nealotus tripes (1)
- Necrosis (1)
- Necrotizing enterocolitis (1)
- Needs assessment [MeSH] (1)
- Negative staining (1)
- Neoadjuvant therapy (1)
- Neonatal (1)
- Neonatal intensive care unit (1)
- Neonatal morbidity (1)
- Neopagetopsis ionah (1)
- Neoplatonism (1)
- Neotropical fungi (1)
- Nerve regeneration (1)
- Nerves (1)
- Network Communities (1)
- Network analysis (1)
- Network models (1)
- Networks (1)
- Neural networks (1)
- Neural pathways (1)
- Neurobiology of disease and regeneration (1)
- Neurodevelopment (1)
- Neuroendocrine cancer (1)
- Neuroimaging (1)
- Neuron-glia interactions (1)
- Neuronal Differentiation (1)
- Neuronal plasticity (1)
- Neurotransmission (1)
- Neutropenia (1)
- Next generation sequencing (1)
- Nfe2l2 (1)
- Niche differentiation (1)
- Nimotuzumab (1)
- Nisaetus pinskeri (1)
- Nobel prizes (1)
- Noether symmetries (1)
- Non-REM sleep (1)
- Non-coding RNA (1)
- Non-interventional study (1)
- Non-responder (1)
- Non-small-cell lung cancer (1)
- Non-trauma (1)
- Noncoding RNA (1)
- Normal distribution (1)
- Normative Orders (1)
- North China Plain (1)
- Nox1 (1)
- Nox4 (1)
- NoxO1 (1)
- Npr2 (1)
- Nuclear interactions (1)
- Nuclear magnetic resonance (1)
- Nuclear reactions (1)
- Nuclear structure & decays (1)
- Nucleon induced nuclear reactions (1)
- Nucleus (1)
- Nucleus pulposus cells (1)
- Numerical simulation (1)
- Numismatics (1)
- Nutrition (1)
- Nymphs (1)
- OCT (1)
- OTC-Märkte (1)
- Object vision (1)
- Observation (1)
- Observational studies (1)
- Obstetrics and gynecology (1)
- Ocean sciences (1)
- Octanoic acid (1)
- Ocular findings (1)
- Ocular tuberculosis (1)
- Odorant receptor (1)
- Oesophageal cancer (1)
- Okinawa (1)
- Okinawa diet (1)
- Old-old (1)
- Older adults (1)
- Oncologic surgery (1)
- Ontologies (1)
- Ontology (1)
- Open abdomen (1)
- Open data data (1)
- Open-source software (1)
- OpenStreetMap (1)
- Operation/Chirurgie (1)
- Operons (1)
- Opossums (1)
- Optic nerve atrophy (1)
- Optimism (1)
- Oral and maxillofacial trauma (1)
- Oral anticoagulation (1)
- Oral surgery (1)
- Orangutans (1)
- Ordinary least squares (OLS) (1)
- Organ dysfunction (1)
- Organ dysfunctions (1)
- Organ support (1)
- Organs at Risk (1)
- Oroantral (1)
- Osimertinib (1)
- Ossifying fibroma (1)
- Osteocalcin (1)
- Osteogenic differentiation (1)
- Outbreak (1)
- Outcome Responsibility (1)
- Outcome assessment (1)
- Outcome assessment [MeSH] (1)
- Outreach practice (1)
- Outsourcing (1)
- Overlapping Generations (1)
- Oxidative stress (1)
- Oxidoreductases (1)
- OxyELITE Pro (1)
- P-gp (1)
- P1NP (1)
- P2P lending (1)
- P2X7 receptor (1)
- P2Y13 receptor (1)
- PAH (1)
- PAI-1 (1)
- PBX1 (1)
- PC12 cells (1)
- PCAOB (1)
- PCR-GLOBWB (1)
- PCV (1)
- PD-L1 (1)
- PD1/ PDL1 (1)
- PDCA (1)
- PDZ domain (1)
- PEGylated PLGA (PLGA-PEG) (1)
- PELDOR/DEER (1)
- PFL (1)
- PGC-1 alpha (1)
- PI3K (1)
- PISA (1)
- PKA (1)
- PPAR gamma activator (1)
- PTCH (1)
- PTDM (1)
- PTK2B (1)
- PTP (1)
- PTSD (1)
- Pacemaker (1)
- Pagetopsis macropterus (1)
- Pain (1)
- Paleobiology (1)
- Pancreatitis (1)
- Parameter space (1)
- Parasites of endangered species (1)
- Pardon (1)
- Parenting behavior (1)
- Parkin (1)
- Parkinson disease (1)
- Parmeliaceae (1)
- Pathological complete response (1)
- Pathology (1)
- Patient Blood Management (1)
- Patient Outcome Assessment (1)
- Patient satisfaction (1)
- Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (1)
- Pecuniary Externality (1)
- Pediatrics [MeSH] (1)
- Peer teaching (1)
- Perception (1)
- Periodontal diseases (1)
- Peritonitis (1)
- Permeability (1)
- Permeation and transport (1)
- Personality differences (1)
- Personality traits (1)
- Personalized medicine (1)
- Peru (1)
- Pessar (1)
- Phage display (1)
- Phagocytosis (1)
- Pharmacodynamics (1)
- Pharmacokinetic Interactions (1)
- Pharmacy setting (1)
- Pharyngeal reflex (1)
- Phase diagram of dense matter (1)
- Phlyctenule (1)
- Phonology (1)
- Phospho-soda (1)
- Phospholipids (1)
- Photobiology (1)
- Photocages (1)
- Photolabile Schutzgruppen (1)
- Photolabile protecting groups (1)
- Photoreceptors (1)
- Phylogenetic analysis (1)
- Phylogeny (1)
- Physical and chemical properties (1)
- Physical environment (1)
- Physical fitness (1)
- Physicians (1)
- Physics (1)
- Physiological parameters (1)
- Physiology (1)
- Pigeons (1)
- PilF (1)
- PillCamColon2 (1)
- Pinus canariensis (1)
- Pitch perception (1)
- Pithecophaga jefferyi (1)
- Plague (1)
- Planck scale (1)
- Planning (1)
- Plant symbiosis (1)
- Plasma physics (1)
- Plasmid construction (1)
- Plasmid mapping (1)
- Podospora anserina (1)
- Pokémon Go (1)
- Political Rights (1)
- Political Risk Insurance (1)
- Polyamides (1)
- Polymerization (Polymers) (1)
- Polyps (1)
- Population (1)
- Population size (1)
- Populus (1)
- Portal hypertension (1)
- Position paper (1)
- Post-transplant (1)
- Postoperative infections (1)
- Posttranslational modification (1)
- Postural control (1)
- Potassium channels (1)
- Poverty (1)
- Power plant (1)
- Power system model (1)
- Power system simulations (1)
- Practice (1)
- Precautionary Saving (1)
- Precipitation (1)
- Preclinical (1)
- Pregnancy (1)
- Preterm birth (1)
- Price Efficiency (1)
- Primary health care (1)
- Primary metabolites (1)
- Primary schools (1)
- Privacy (1)
- Privacy Concerns (1)
- Privacy Policies (1)
- Private Information (1)
- Private Investment (1)
- Probability Weighting Function (1)
- Procaine (1)
- Profit (1)
- Progesteron (1)
- Progesterone (1)
- Prognosefaktoren (1)
- Prognostic markers (1)
- Program Evaluation (1)
- Programming languages (1)
- Progranulin (1)
- Proinflammatory cytokines (1)
- Proliferation (1)
- Proline (1)
- Prolyl 4 hydroxylases (1)
- Prostate Cancer (1)
- Prostate cancer cell lines (1)
- Prosthetic rehabilitation (1)
- Protein folding (1)
- Protein turnover (1)
- Proteomics (1)
- Prothrombin complex concentrate (1)
- Proton (1)
- Proton number fluctuations (1)
- Prudential oversight (1)
- Prädiktivfaktoren (1)
- Präsenzlehre (1)
- Pseudochaenichthys georgianus (1)
- Pseudoterranova (1)
- Psicanálise (1)
- Psychiatric disorders (1)
- Psychoanalysis (1)
- Psychometrics (1)
- Psychophysics (1)
- Psychotherapy (1)
- Pterolichoidea (1)
- Public and occupational health (1)
- Public pension funds (1)
- Pulmonary artery pressure (1)
- Pulmonary embolism (1)
- Pump-and-dump schemes (1)
- Purkinje cells (1)
- Puumala virus (1)
- Pyramidal cells (1)
- Pyruvate (1)
- Python (1)
- Qualitative research [MeSH] (1)
- Quality of health care [MeSH] (1)
- Quantitative MRI (1)
- Quantitative trait loci (1)
- Quantum chemistry (1)
- Quantum gravity (1)
- Quark-Gluon Plasma (1)
- Quarkonium (1)
- Quercetin (1)
- Quinolinate Phosphoribosyltransferase (1)
- Quinolinate phosphoribosyltransferase (1)
- Quinolinic acid (1)
- Quotas (1)
- Q‐method (1)
- RADseq (1)
- RDF (1)
- REM sleep (1)
- RNA and RNA-protein complexes (1)
- RNA therapy (1)
- RNA viruses (1)
- RNASolution-state NMR (1)
- ROS (1)
- Rab7 (1)
- Radiative transfer (1)
- Radical nephrectomy (1)
- Rain (1)
- Rainfall (1)
- Ramon Llull (1)
- Randomized (1)
- RapL (1)
- Rapamycin (1)
- Rare diseases (1)
- Rawls, John (1)
- Re-exploration (1)
- Reactive oxygen species (1)
- Reading Flow Short Scale (1)
- Rearing temperature (1)
- Red blood cell transfusion (1)
- Redox dependent epigenetic modifications (1)
- Redox modification (1)
- Redox-sensitive transcription factor (1)
- Regeneration (1)
- Regression analysis (1)
- Regulation (1)
- Regulatory networks (1)
- Reintervention (1)
- Relativismus (1)
- Remote monitoring (1)
- Renal cancer (1)
- Renal system (1)
- Reproductive potential (1)
- Research Article (1)
- Research architecture (1)
- Resource competition (1)
- Respiratory tract diseases (1)
- Response criteria (1)
- Responsibilization (1)
- Resuscitation (1)
- Retina (1)
- Retinal degeneration (1)
- Return to play (1)
- Reversible Jump Markov Chain Monte Carlo (1)
- Rheumatoid arthritis (1)
- Ribosome Recycling (1)
- Ribosome display (1)
- Richtlinie (1)
- Risk Beliefs (1)
- Rivaroxaban (1)
- Rodent-associated infections (1)
- Rostock (1)
- Rudder stock (1)
- Rural area (1)
- Ruxolitinib (1)
- Ryanodine receptors (1)
- Rydberg (1)
- S1P (1)
- SAVI (1)
- SCMR (1)
- SDH (1)
- SIFI (1)
- SKAP1 (1)
- SMAD signaling (1)
- SOFA (1)
- SPARQL (1)
- SPME-GCMS (1)
- SRM (1)
- SSM (1)
- SSR128129E (1)
- STED superresolution (1)
- STING (1)
- STK3 (1)
- Saccharomyces cerevisiae (1)
- Safety equipment (1)
- Safety learning (1)
- Salamanca (1)
- Saliva (1)
- Salmantizenser (1)
- Salmonella Typhimurium (1)
- Salmonella-induced filaments (1)
- Sarcoidosis (1)
- Schengen Information System (1)
- Schwinger effect (1)
- Sci-Hub (1)
- Scientific publishing (1)
- Scribble (1)
- Scrofulous keratitis (1)
- Seasonal (1)
- Seasonal fluctuation (1)
- Seasonal trend decomposition (1)
- Seasons (1)
- Secondary metabolism (1)
- Secondary metabolites (1)
- Securities regulation (1)
- Sedimentology (1)
- Segmentation (1)
- Selbstkonzept (1)
- Self-massage (1)
- Sensory Neuroscience (1)
- Sensory perception (1)
- Septic shock (1)
- Serum (1)
- Service-learning (1)
- Settlement Latency (1)
- Severe blood loss (1)
- Severity of illness index (1)
- Sex differences (1)
- Sex education (1)
- Shannon index (1)
- Shared gaze (1)
- Shell model (1)
- Sholl analysis (1)
- Short-chain fatty acids (1)
- Sicherheitenmarge (1)
- Sigmund Freud (1)
- Signal processing (1)
- Similarity (1)
- Simulated patients (1)
- Sin Stocks (1)
- Single-cell RNA-seq (1)
- Slavkovska (1)
- Slow-Moving Capital (1)
- Smac mimetic (1)
- Small-cell lung cancer (1)
- Smart nebulizer (1)
- Smoking habits (1)
- Social communication (1)
- Social construction of technology (1)
- Social psychology (1)
- Social research (1)
- Social sciences (1)
- Social systems (1)
- Socio-cultural factors (1)
- Socio-ecology (1)
- Software development practice (1)
- Solanum lycopersicum (1)
- Solid Earth sciences (1)
- Solidworks 2015 (1)
- Soluble epoxide hydrolase (sEH) (1)
- Soluble proteins (1)
- Solvency II (1)
- Sovereign (1)
- Sovereign Bonds (1)
- Sovereign Debt (1)
- Sovereignty (1)
- Soybean (1)
- Spatial Attention (1)
- Spatio-temporal patterns (1)
- Specialized Information Service (1)
- Species composition (1)
- Species diversity (1)
- Spectroscopic factors & electromagnetic moments (1)
- Speech (1)
- Sphingolipids (1)
- Spine Register (1)
- Spirochetes (1)
- Sportpsychologie (1)
- Spot sign (1)
- SseJ (1)
- Standards of care (1)
- Starvation (1)
- State Civil Disobedience (1)
- State of exception (1)
- Statistical data (1)
- Statistical distributions (1)
- Statistical methods (1)
- Statistical model (1)
- Status epilepticus (1)
- Stellar structure (1)
- Stenotrophomonas maltophilia (1)
- Stereotactic radiosurgery (1)
- Stoa (1)
- Stochastic (1)
- Stock Market (1)
- Stoma (1)
- Storage Ring (1)
- Strangeness (1)
- Strength training (1)
- Streptococcus pneumoniae (1)
- Stress vulnerability/resilience genes (1)
- String similarity (1)
- Stringed bow player (1)
- Structural MRI (1)
- Structural biology and molecular biophysics (1)
- Structural genomics (1)
- Structure-based drug discovery (1)
- Structure-function interplay (1)
- Structured Illumination Microscopy (1)
- Study protocol (1)
- Sub-hourly scale (1)
- Subjective Survival Beliefs (1)
- Subtropical East-Atlantic (1)
- Suicide (1)
- Sulfasalazine (1)
- Sulphoraphane (1)
- Sumatra (1)
- Sumerian (1)
- Super resolution (1)
- Super resolution fluorescence microscopy (1)
- Superconducting devices (1)
- Superconducting properties and materials (1)
- Supraspinatus tendon (1)
- Surgical ICU (1)
- Surgical site occurrence (1)
- Survival analysis (1)
- Survival data (1)
- Svetamycin (1)
- Sweat osmolality (1)
- Sweat secretion rate (1)
- Swimming (1)
- Syllables (1)
- Sympathetic nerve (1)
- Synaptic plasticity (1)
- Syncope (1)
- Syntax (1)
- Synthetic (1)
- Systematic Internalizer (1)
- Systematisches Risiko (1)
- T cell (1)
- T cells (1)
- T helper 17 cells (1)
- T-DM1 (1)
- T-cell targeting (1)
- T-cells (1)
- T1 mapping (1)
- TALE-homdomain protein (1)
- TARGET (1)
- TAVR (1)
- TBSS (1)
- TC stenosis (1)
- TEMPO (1)
- TEPT (1)
- TF-complexes (1)
- TLR (1)
- TMS-EEG (1)
- TNF inhibitors (1)
- TNF-α (1)
- TOR inhibitor (1)
- TP53 mutation status (1)
- Target identification (1)
- Targeted therapy (1)
- Task switching (1)
- Tax (1)
- Taxation of Capital (1)
- Taxonomy (1)
- Teacher Education (1)
- Teachers (1)
- Technique (1)
- Telemedicine (1)
- Temporal lobe epilepsy (1)
- Temporal variation (1)
- Term Structure of Interest Rates (1)
- Term birth (1)
- Terpenes (1)
- Testosterone (1)
- Tet-inducible system (1)
- Text mining (1)
- The D-statistic (1)
- Theodor Adorno (1)
- Theoretical Classification (1)
- Theoretical nuclear physics (1)
- Thermalization (1)
- Thermoanaerobacter kivui (1)
- Thermophiles (1)
- Thermoregulation (1)
- Thomism (1)
- Three-Pillar-System (1)
- Three-dimensional back scan (1)
- Thrombosis (1)
- Thyroid (1)
- Tick-Borne diseases (1)
- Tick-borne encephalitis (1)
- Timing (1)
- Tinnitus (1)
- Toluidine blue (1)
- Tomography (1)
- Tomosynthese (1)
- Tools and resources (1)
- Tools and ressources (1)
- Tooth transplantation (1)
- Torque (1)
- Tortoise beetles (1)
- Toxicity (1)
- Trading (1)
- Trading volume (1)
- Training (1)
- Tranexamic acid (1)
- Transaction costs (1)
- Transcription (1)
- Transcription Factors (1)
- Transferases (1)
- Transfusion (1)
- Transgenesis (1)
- Transgenic SK-2 mice (1)
- Translation initiation (1)
- Transparency (1)
- Transportation (1)
- Transversity (1)
- Trauma surgery (1)
- Trauma índice (1)
- Traumatic brain injury (1)
- Traumatic experiences (1)
- Traumatic injury (1)
- Tribolium castaneum (1)
- Trichiurus lepturus (1)
- Trichuris suis ova (1)
- Triple negative (1)
- Triple therapy (1)
- Triple-negative breast cancer (1)
- Troponin (1)
- Trust Beliefs (1)
- Tubers (1)
- Tumor infiltrating lymphocytes (1)
- Tumour biomarkers (1)
- Type 2 diabetes (1)
- Tyrosine prototrophy (1)
- UCN-01 (1)
- UDP-glucose ceramide glycosyltransferase (1)
- UGCG (1)
- ULBP4 (1)
- US culture (1)
- US executive-legislative relations (1)
- US presidency (1)
- UWB diagnostics (1)
- Ubiquitin (1)
- Ubiquitination (1)
- Ultra microscopy (1)
- Ultraschall (1)
- Ultrasonic nebulizer (1)
- Ultrasound imaging (1)
- Unconventional Monetary Policy (1)
- Upper body posture (1)
- Urologic tumors (1)
- Ursus arctos (1)
- Ustilaginaceae (1)
- Ustilaginomycotina (1)
- Usutu virus (1)
- V/Sc (1)
- V4 (1)
- VEGF (1)
- VIP1 (1)
- Vaccination breakthrough (1)
- Vaccine (1)
- Vaishnava Krishna Caitanya Kirtan (1)
- Value creation (1)
- Vascular emergencies (1)
- Vector mosquito (1)
- Vein density (1)
- Vein networks (1)
- Verbal behavior (1)
- Verlustbeteiligung (1)
- Viral core (1)
- Viral replication (1)
- Virtual drug screening (1)
- Virtual reality (1)
- Visual Perception (1)
- Visual acuity (1)
- Visual cortex (1)
- Visual search (1)
- Vitamin (1)
- Vitoria (1)
- Volatility (1)
- Volumetric analysis (1)
- W-exchange (1)
- W3 (1)
- WGHM (1)
- Wahrheit (1)
- Warburg effect (1)
- Water chemistry (1)
- Weight loss (1)
- Well-being (1)
- West Africa (1)
- West Nile fever (1)
- West Nile neuroinvasive disease (1)
- West Nile virus (1)
- White-rot (1)
- Within-host infection (1)
- Women (1)
- Work shadowing (1)
- Working memory (1)
- WpHG (1)
- X-ray crystallography (1)
- X-ray generation (1)
- X-ray irradiation (1)
- X-ray spectroscopy (1)
- XL probe (1)
- Yarrowia lipolytica (1)
- Yarrowia lipolytica F1Fo-ATP synthase (1)
- YbNi4P2 (1)
- YbRh2Si2 (1)
- Yeast (1)
- Young-old (1)
- Zentrales Clearing (1)
- Zero lower bound (1)
- Zervixverkürzung (1)
- Zika (1)
- Zika vaccine (1)
- Zika virus (1)
- Zirconia (1)
- Zoopotentation (1)
- Zooprophylaxis (1)
- abemaciclib (1)
- abnormal tumor vasculature (1)
- abuso sexual infantil (1)
- academic development (1)
- accident (1)
- acclimation (1)
- accounting (1)
- acetaminophen (1)
- acetogenesis (1)
- acetyl-CoA (1)
- action memory (1)
- activation receptors (1)
- active sensing (1)
- active/deactive transition (1)
- activity sensors (1)
- actography (1)
- actor (1)
- acute cholecystitis (1)
- acute coronary syndrome (1)
- acute exacerbations of COPD (1)
- acute inflammation (1)
- acute myeloid leukemia (1)
- adaptation (1)
- adeno-associated viruses (AAV) (1)
- adenosine receptors (1)
- adherence (1)
- adhesion (1)
- adipose-derived mesenchymal stem cells (1)
- adolescence (1)
- adoptive cell therapy (1)
- adoptive immunotherapy (1)
- advanced breast cancer (1)
- adverse reaction (1)
- adverse selection (1)
- aegean (1)
- aerosol (1)
- aerosol formation (1)
- aerosols (1)
- aesthetic liking (1)
- affected interests (1)
- affective disorder (1)
- age-friendly cities and communities (1)
- agency (1)
- agglomeration (1)
- aggregate risk (1)
- aggregate uncertainty (1)
- agonism (1)
- agricultural commodity (1)
- airway remodeling (1)
- aliphatic halogenated hydrocarbons (1)
- alirocumab (1)
- all-affected principle (1)
- allergen immunotherapy (1)
- allergic rhinitis (1)
- allogeneic stem cell transplantation (1)
- allostery (1)
- alpinia zerumbet (1)
- ambulatory assessment (1)
- anaesthesia in orthopaedics (1)
- anaesthetics (1)
- anarchy (1)
- anastomotic leakage (1)
- anatomy (1)
- anatomy and histology (1)
- and translation (1)
- anger (1)
- annuity (1)
- anti-GD2 immunotherapy (1)
- anti-idiotypes (1)
- anti-inflammatory (1)
- antibiotic (1)
- antibiotic therapy (1)
- antibodies (1)
- anticonvulsants (1)
- antigen presentation (1)
- antigen processing (1)
- antihormone therapy (1)
- antimicrobial activity (1)
- antimicrobial resistance (1)
- antioxidant (1)
- antioxidant activity (1)
- antisense oligonucleotides (1)
- antiviral therapy (1)
- aortic stenosis (1)
- aplicabilidad (1)
- apoptosis (1)
- apps (1)
- aptamer (1)
- aquaporin 1 (1)
- arachidonate 15-lipoxygenase (1)
- arachidonic acid (1)
- aroma (1)
- art market (1)
- artificial intelligence (1)
- artificial magnetic lattices (1)
- ascites (1)
- asexual fungi (1)
- asset managers (1)
- asset purchases (1)
- asthma (1)
- asymmetric and private information (1)
- asymptotic behavior (1)
- atheism (1)
- atrial fibrillation (1)
- atrial septostomy (1)
- atrophy (1)
- attachment (1)
- attachment figures (1)
- attachment networks (1)
- augmented reality (1)
- autobiographical reasoning (1)
- autoimmunity (1)
- autologous stem cell transplantation (1)
- automated deduction (1)
- automatic (1)
- autores araboislámicos (1)
- autors araboislàmics (1)
- avelumab (1)
- average mutual information (1)
- axon bifurcation (1)
- axonal pathfinding (1)
- back scan (1)
- bacterium (1)
- balance regulation (1)
- balance sheet risk (1)
- balanced state (1)
- bank accounting (1)
- bank lending (1)
- barrier loci (1)
- basal cell carcinoma (1)
- basic leucine zipper transcription factor ATF-like (1)
- bats (1)
- beta blockade (1)
- betaine/choline/carnitine transporter (1)
- betamethasone dipropionate (1)
- bevacizumab (1)
- bibliometric analysis (1)
- bibliometry (1)
- bio imaging (1)
- bioactive phytochemicals (1)
- biodiesel (1)
- biogeographic legaciese (1)
- bioluminescence (1)
- biomarker (1)
- biometrics (1)
- biopsy (1)
- biorelevant dissolution tests (1)
- bipolar disorders (1)
- birch pollen allergoid (1)
- bistable perception (1)
- block jumping (1)
- blood (1)
- blood donor (1)
- blow flies (1)
- blow fly (1)
- body politic (1)
- body posture (1)
- bonds (1)
- bone remodeling (1)
- bone resorption (1)
- border (1)
- borderline personality disorder (1)
- borrelia (1)
- boswellic acid (1)
- brachytherapy (1)
- brain-state-dependent stimulation (1)
- breast (1)
- broadly neutralizing antibodies (1)
- bronchodilator (1)
- brown bear (1)
- buccal mucosa (1)
- bulk viscosity (1)
- cAMP (1)
- cFLIP (1)
- cGKI (1)
- calcification score (1)
- calcipotriol (1)
- calcium-independent phospholipase A2β (1)
- cancer stem cells (1)
- capital maintenance (1)
- capital markets (1)
- capital structure (1)
- capital-labor ratio (1)
- carbon tetrachloride (1)
- cardiovascular diseases (1)
- cardiovascular precision medicine (1)
- carnitine metabolism (1)
- case study (1)
- caspase-2 (1)
- cathepsin (1)
- causal inferences (1)
- ceRNA (1)
- celery (1)
- cell biology (1)
- cell cycle (1)
- cell respiration (1)
- cell surface hydrophobicity (1)
- cell types (1)
- cellular signalling (1)
- centenarians (1)
- center embedding (1)
- central bank independence (1)
- central bank policy (1)
- central nervous system modifications (1)
- centrosome (1)
- centrosome linker (1)
- cerclage (1)
- cerebellar granule cells (1)
- cerebrospinal fluid (1)
- cervical shortening (1)
- cervical spine (1)
- cervico-thoracic junction (1)
- ch14.18/CHO (1)
- challenged locomotion (1)
- chamomile (1)
- changepoint (1)
- charge-cluster glass (1)
- checkpoint inhibition (1)
- chemokine (1)
- chemotaxis (1)
- chemotherapeutic drug resistance (1)
- child abuse and neglect (1)
- child maltreatment (1)
- childhood sexual abuse (1)
- children (1)
- cholangiocarcinoma (1)
- cholesterol (1)
- chromatography (1)
- chromosomal integration (1)
- cilia (1)
- circadian rhythms (1)
- circadian variation (1)
- circular emotional process (1)
- cisplatin resistance (1)
- citizen engagement (1)
- citizens (1)
- citizenship (1)
- clathrin heavy chains (1)
- click chemistry (1)
- client involvement (1)
- climate (1)
- climatic variability (1)
- clinical COPD questionnaire (1)
- clinical management (1)
- clinical practice (1)
- clinical trial (1)
- closed-end funds (1)
- closed-loop robots (1)
- clostridia (1)
- clumped isotopes (1)
- clusivity (1)
- co-culture model (1)
- coastal geomorphology (1)
- cocrystals (1)
- code:Matlab (1)
- cognition (1)
- cognitive behaviour therapy (1)
- cognitive decline (1)
- cognitive development (1)
- cognitive states (1)
- cognitive training (1)
- cognitive-motor interference (1)
- cohort study (1)
- colitis (1)
- collaborative governance (1)
- collagen (1)
- collagen-based biomaterial (1)
- collective agency (1)
- collective dynamics (1)
- colon (1)
- colon carcinoma cells (1)
- column chromatography (1)
- combination (1)
- combination therapy (1)
- combined immunodeficiency (1)
- comentarios alejandrinos (1)
- comentaris alexandrins (1)
- commodities (1)
- communion (1)
- comparability (1)
- compatible solutes (1)
- compensation (1)
- compensation design (1)
- competition (1)
- competitiveness (1)
- complement dependent cytotoxicity (1)
- complementary information (1)
- complex I (1)
- complexome profiling (1)
- compliant robot (1)
- complications (1)
- component study (1)
- composite structures (1)
- computational chemistry (1)
- computational virology (1)
- computer-assisted drug therapy (1)
- conceptual history (1)
- concerns for information privacy (CFIP) (1)
- conflict of laws (1)
- conformational dynamics (1)
- conformational flexibility (1)
- congenic mice (1)
- conquest (1)
- consciousness (1)
- consequentialism (1)
- constituent power (1)
- constitutionalism (1)
- constitutions without constitutionalism (1)
- construction procurement (1)
- consumption (1)
- consumption commitments (1)
- contact lens solution (1)
- contest (1)
- contextual equivalence (1)
- contingent capital (1)
- continuation vote (1)
- continuous glucose monitoring (1)
- contract law (1)
- controlled diffusions and jump processes (1)
- controlled nuclear import (1)
- conventional monetary policy (1)
- coping (1)
- copyright (1)
- coronary (1)
- coronary disease (1)
- corporate income tax (1)
- correctness (1)
- corrosion (1)
- cortical activity (1)
- corticospinal excitability (1)
- cosmopolitanism (1)
- cost-benefit analysis (1)
- counter-democracy (1)
- counter-governance (1)
- cover times (1)
- critical gerontology (1)
- criticality (1)
- cross reactivity (1)
- cross-border cooperation (1)
- cross-cultural comparison (1)
- cross-linguistic influence (1)
- crowdfunding (1)
- crowdinvesting (1)
- crowdlending (1)
- crowdsponsoring (1)
- cryo-electron tomography (1)
- cryoballoon (1)
- cryptocurrencies (1)
- crystal engineering (1)
- crystal structure (1)
- cult of immediacy (1)
- cultural diversity (1)
- cultural heritage (1)
- cultural life script (1)
- cumulative dose (1)
- cumulative trauma (1)
- currencies (1)
- curriculum (1)
- cytarabine dose (1)
- cytochrome P450 2E1 (1)
- cytokine release syndrome (1)
- cytokine-induced killer cells (1)
- cytotoxic T cells (1)
- dabrafenib (1)
- damage associated molecular pattern (1)
- data assimilation (1)
- data protection (1)
- data structure (1)
- data-science (1)
- decision aids (1)
- decision-making (1)
- deduction (1)
- deforestation (1)
- degree of saturation (1)
- delayed cholecystectomy (1)
- delirium (1)
- delta-9-tetrahydrocannabinol (1)
- democracy (1)
- democratic commitments (1)
- democratic deficit (1)
- democratic ideals (1)
- democratic innovation (1)
- demographic trends (1)
- dendritic cells (1)
- dendritic inhibition (1)
- dendroecology (1)
- density functional theory (1)
- dental abutment (1)
- dental implants (1)
- dentate gyrus (1)
- deposition; dissociation; electron beam induced deposition (EBID); focused electron beam induced deposition (FEBID); precursor; trimethyl(methylcyclopentadienyl)platinum(IV) ((CH3-C5H4)Pt(CH3)3) (1)
- dermatology (1)
- developmental task (1)
- developmental temperature (1)
- dexamethasone (1)
- diabetes (1)
- diabetic macular edema (1)
- diagnostics (1)
- diesel (1)
- dietary supplements (1)
- differentiated thyroid carcinoma (1)
- differentiation (1)
- diffuse low-grade glioma (1)
- diffusion model (1)
- digital age determination (1)
- digital heritage (1)
- digitalization (1)
- dihydroceramides (1)
- diligence (1)
- diplopia (1)
- direct testing effect (1)
- direct-acting antivirals (1)
- discount (1)
- discursive institutionalism (1)
- disease progression (1)
- disintegration (1)
- disorder (1)
- displacement (1)
- dissidence (1)
- dissociative electron attachment (1)
- dissociative ionization (1)
- distributed ledger technology (1)
- distribution-based bifurcation model (1)
- diurnal cycle (1)
- divalent metal ions (1)
- diversity (1)
- doing age (1)
- dominion (1)
- dominium (1)
- dose response curve (1)
- doxorubicin (1)
- doxycycline (1)
- dreaming (1)
- drug discovery (1)
- drug interaction (1)
- drug release (1)
- drug-coated balloon (1)
- drug-eluting balloon (1)
- dsRNA (1)
- dual-task (1)
- duration of pay (1)
- dynamic balance task (1)
- dynamic stimuli (1)
- dynamical mean-field theory (1)
- dynamics (1)
- eNPP2 (1)
- ePR (1)
- ePrivacy Regulation (1)
- early cholecystectomy (1)
- earth observation (1)
- ecocultural approach (1)
- ecological speciation (1)
- economic crisis (1)
- economic growth (1)
- economic participation (1)
- economic policy uncertainty (1)
- economic surprises (1)
- ectosomes (1)
- ectotherm (1)
- educational cases (1)
- educational measurement (1)
- efficacy (1)
- egr-1 (1)
- elderly (1)
- elections (1)
- electrical resistivity tomography (1)
- electromechanical impedance (1)
- electron bifurcation (1)
- electron induced deposition (1)
- electron microscopy (1)
- electron molecule interaction (1)
- electron transfer (1)
- electrophysiology (1)
- elephant (1)
- elevational gradient (1)
- elite sports (1)
- embedded implicature (1)
- embodiment (1)
- emotion regulation (1)
- emotional competence (1)
- emulsion diffusion (1)
- enactment (1)
- encoding (1)
- endemic (1)
- endogenous clock (1)
- endogenous risk (1)
- endophilin (1)
- endosomal tubulation (1)
- endothelial activation (1)
- endothelial barrier (1)
- endothelial cell (1)
- endothelial nitric-oxide synthase (1)
- energy system simulations (1)
- energy-dispersive x-ray spectroscopy (1)
- ensemble refinement (1)
- environmental attitudes (1)
- environmental behavior (1)
- environmental education (1)
- environmental gerontology (1)
- environmental knowledge (1)
- enzyme activity (1)
- epidemics (1)
- epidemiology (1)
- epileptic encephalopathies (1)
- epitope vaccine (1)
- equilibrium (1)
- equity (1)
- equity premium (1)
- erasure codes (1)
- error correction codes (1)
- ester (1)
- ethics (1)
- ethnography (1)
- ethnomethodology (1)
- eukaryotic system (1)
- event study (1)
- event-based (1)
- evolution (1)
- exact exchange (1)
- excitability (1)
- exercise (1)
- exhaustivity (1)
- experimental pragmatics (1)
- exploitation (1)
- exponential model (1)
- extracellular matrix (1)
- extracellular vesicles (1)
- extracting solvents (1)
- extreme value theory (1)
- eye tracking (1)
- fMRI (1)
- face (1)
- face inversion (1)
- face perception (1)
- facebook (1)
- faces (1)
- facial EMG (1)
- facial emotion recognition (1)
- facial expressions of emotion (1)
- facial muscle activity (1)
- factor H (1)
- faculty development (1)
- fair trade (1)
- fake news (1)
- falls (1)
- false memory (1)
- false-nearest neighbors (1)
- family policy (1)
- fatty acid/biosynthesis (1)
- fear learning (1)
- feasibility (1)
- feedback neurons (1)
- felicity judgment (1)
- female subjects (1)
- femoropopliteal segment (1)
- fermentation (1)
- fibrinolysis (1)
- fibrosis (1)
- fiction reading (1)
- fight against crime (1)
- filopodia (1)
- finance and technology (1)
- financial advice (1)
- financial decision-making (1)
- financial development (1)
- financial innovation (1)
- financial innovations (1)
- financial literacy (1)
- financial literacy determinants (1)
- financial market data (1)
- financial structure (1)
- financial supervision (1)
- financial transaction data (1)
- first-price auctions (1)
- flow (1)
- flow cytometry (1)
- fluctuation spectroscopy (1)
- fluocinolone acetonide (1)
- focal adhesion (1)
- follow‑up (1)
- food security (1)
- football coach (1)
- foraminifera (1)
- forensics (1)
- forest classification (1)
- forest functional similarity (1)
- forest tree (1)
- formate dehydrogenase (1)
- forward guidance (1)
- fractional Fourier transform (1)
- fractionation (1)
- frankincense (1)
- free speech (1)
- fringe politics (1)
- functional connectivity (1)
- functional genomics (1)
- functional magnetic resonance imaging (1)
- functional magnetic resonance imaging (fMRI) (1)
- functional programming (1)
- fungi (1)
- fungus (1)
- galactography (1)
- galactomannan (1)
- galactomosynthesis (1)
- gallstone disease (1)
- game–theoretic pragmatics (1)
- gangliosides (1)
- gastric cancer (1)
- gastro-oesophageal junction cancer (1)
- gastrointestinal drugs (1)
- gender (1)
- genderroles (1)
- gene delivery (1)
- gene expression (1)
- gene flow (1)
- gene therapy (1)
- gene vectors (1)
- general anaesthesia (1)
- general practice (1)
- genetic analysis (1)
- genomics (1)
- geophysical prospections (1)
- geriatric medicine (1)
- germinal center (1)
- giraffe (1)
- glass-like structural ordering (1)
- glioma (1)
- glioma-associated oncogene homolog (1)
- gliomas (1)
- global democracy (1)
- global governance (1)
- global mapping (1)
- global poverty (1)
- glucocorticoid (1)
- glucose metabolism (1)
- glucose transport (1)
- glycerophospholipid (1)
- glycolysis (1)
- glycosphingolipids (1)
- graft perfusion (1)
- graft rejection (1)
- graft-versus-host disease (1)
- graft-versus-tumor effect (1)
- granulocytemacrophage colony-stimulating factor (1)
- granulomas (1)
- granulomatous inflammation (1)
- grapes (1)
- great recession (1)
- green tea extract (1)
- grounded theory (1)
- groundwater storage (1)
- group law (1)
- group x age interaction (1)
- growth rates (1)
- guanylyl cyclase (1)
- guideline (1)
- guidelines (1)
- hanging donors (1)
- hardwood (1)
- head and neck squamous cell carcinoma (1)
- head-and-neck cancer (1)
- headache (1)
- health (1)
- health care personnel (1)
- health information exchange (1)
- health services accessibility (1)
- health-related quality of life (1)
- heart failure (1)
- heavy ion experiments (1)
- hedge funds (1)
- hedgehog signaling pathway (1)
- hedging errors (1)
- helminths (1)
- hematopoietic stem cells (1)
- hemophilia a (1)
- hepatitis B virus (1)
- hepatitis C virus (HCV) (1)
- hepatitis E virus (1)
- hepatocyte transplantation (1)
- herbivores (1)
- hereditary angioedema (1)
- heritage language (1)
- heritage speakers (1)
- herpes simplex virus type 1 (1)
- herpes simplex virus type 2 (1)
- heteronuclear FEBID precursors (1)
- heuristics (1)
- hierarchical fields (1)
- hierarchical modeling (1)
- hierarchy (1)
- high-resolution atmospheric modelling (1)
- high-resolution simulation (1)
- hip and ankle strategies (1)
- hippocampal neuronal cell line (1)
- hippocampal neurons (1)
- histone acetylation (1)
- histone deacetylase (1)
- histone deacetylase 5 (1)
- homeostasis (1)
- hominin adaptation (1)
- honeybee (1)
- honorable merchant (1)
- host-targeting antivirals (1)
- hours per capita measurement (1)
- house price (1)
- human biology and medicine (1)
- human capital investment (1)
- human host adaptation (1)
- human monocytes (1)
- human neocortex (1)
- human papilloma virus (1)
- human pathogen (1)
- human renal proximal tubular epithelial cells (1)
- human rights (1)
- human-wildlife conflict (1)
- humanized mouse (1)
- humans (1)
- humoral factors (1)
- hxt0 strain (1)
- hybrid (1)
- hybrid assembly (1)
- hybrid energy sources (1)
- hybridization (1)
- hydrocephalus (1)
- hydrogen bonds (1)
- hydrogen production (1)
- hydrogen storage (1)
- hydrogenase (1)
- hydroxyapatite crystals (1)
- hydroxyproline (1)
- hyperbaric oxygen treatment (1)
- hyperconjugative interaction (1)
- hyperlipidemia (1)
- hypocotyls (1)
- hypothalamus (1)
- hypoxia-induced cell death (1)
- ideational shift (1)
- identification (1)
- idiosyncratic risk (1)
- idle time (1)
- illegal migration (1)
- imitation (1)
- immigration (1)
- immune (1)
- immune reconstitution (1)
- immunohistochemistry (1)
- imperfect duty (1)
- in vitro test system (1)
- in-cabin exposure (1)
- incentives (1)
- income dependent inflation (1)
- index trauma (1)
- indigenous culture (1)
- individual differences (1)
- individual investors (1)
- individualistic identity (1)
- inducible gene expression (1)
- industrial organization (1)
- industry sector (1)
- inequality (1)
- infectivity (1)
- infidels (1)
- inflammasome (1)
- inflation (1)
- inflation target (1)
- influenza (1)
- influenza vaccine (1)
- information (1)
- information decomposition (1)
- informativeness principle (1)
- infrastructure improvements (1)
- inhaler (1)
- inhibitor (1)
- inhibitors (1)
- innate lymphoid cells (1)
- insulin resistance (1)
- insurance industry (1)
- insurance market (1)
- integration (1)
- integrin (1)
- integrins (1)
- intellectual property (1)
- interest (1)
- interfaces (1)
- interferon (1)
- interferon gamma (1)
- interleukin-1 (1)
- interleukin-18 (1)
- interleukin-1β (1)
- interleukin-23 receptor (1)
- internal transcribed spacer (1)
- international organizations (1)
- interneuron types (1)
- interneurons (1)
- interstitial brachytherapy (1)
- intervertebral disc degeneration (1)
- intestinal graft-versushost disease (1)
- intra-individual variability (1)
- intracellular protein localization (1)
- intracellular trafficking (1)
- intraperitoneal therapy (1)
- intraventricular chemotherapy (1)
- intrinsically disordered protein (1)
- invasion (1)
- investigación de resultados psicoterapéuticos (1)
- investments (1)
- invincible ignorance (1)
- ionomycin (1)
- irradiation (1)
- ischemic type biliary lesions (1)
- isk premiums (1)
- islam (1)
- isocaloric ketogenic diet (1)
- isorhamnetin (1)
- isovaleric acidaemia (1)
- journals (1)
- just war (1)
- just war theory (1)
- kavalactones (1)
- keratinocytes (1)
- kinase inhibitor (1)
- kinesin (1)
- knockout mice (1)
- knowledge discovery (1)
- labor demand (1)
- labor hoarding (1)
- labor supply (1)
- laceration (1)
- lambda calculus (1)
- land surface datasets (1)
- land-use/cover change modeling (1)
- lapatinib (1)
- larval morphology, identification (1)
- laser plasma emission (1)
- laser-matter interaction (1)
- late lumen loss (1)
- lattice-supersolid (1)
- laws of war (1)
- layer 1 (1)
- layer 1 interneurons (1)
- layoff risk (1)
- leadership (1)
- learning about jumps (1)
- leasing (1)
- legacy software (1)
- legislative presidency (1)
- legislative success (1)
- leptomeningeal metastases (1)
- levetiracetam (1)
- lichens (1)
- life cycle saving (1)
- life narrative (1)
- life stage association (1)
- life story (1)
- life-cycle behavior (1)
- lifecycle (1)
- lifespan (1)
- limit cycles (1)
- linguistic linked open data (1)
- linguistics (1)
- linked open data (1)
- lipid metabolism (1)
- lipidomics (1)
- lipoxygenase (1)
- literature (1)
- liver cirrhosis (1)
- liver fibrosis (1)
- liver transplantation (1)
- load and structural monitoring (1)
- loan loss allowances (1)
- local recurrence (1)
- locusts (1)
- long-acting muscarinic antagonist (1)
- long-term follow-up (1)
- long-term infusion (1)
- longevity (1)
- longevity risk (1)
- low frequency trends (1)
- low-resource languages (1)
- low-wage (1)
- lowland tropical forest (1)
- lucid dreaming (1)
- lung cancer (1)
- lung function (1)
- lung remodeling (1)
- lung transplantation (1)
- lymphocyte (1)
- lymphoma (1)
- lysosomal storage disorders (1)
- lysosome (1)
- mRNA translation (1)
- mTOR (1)
- mTOR inhibitor (1)
- mTORC1 (1)
- machine reasoning (1)
- machine-learning (1)
- macroeconomic conditions (1)
- macroeconomic experiences (1)
- macroeconomic risks (1)
- macromolecular complexes (1)
- macroprudential regulation (1)
- macula (1)
- magnetic gradiometry (1)
- magnetic nanostructures (1)
- magnetoencephalography (1)
- magnitude estimation (1)
- maintenance (1)
- major facilitator superfamily (1)
- malignancy (1)
- many-body blockade (1)
- mapping (1)
- marginal bone loss (1)
- marine oil spills (1)
- marine structures (1)
- market discipline (1)
- marketplace lending (1)
- markovianity (1)
- massively parallel multigrid solvers (1)
- materialism (1)
- maternal care (1)
- mathematical modeling (1)
- measure development/validation (1)
- measurement (1)
- mechanobactericidal surfaces (1)
- medical illustration (1)
- medical school (1)
- medication reconciliation (1)
- membrane fatty acids (1)
- membrane fluidity (1)
- membrane proteins (1)
- membranes (1)
- membranes/fluidity (1)
- memebrane (1)
- memory (1)
- mental health (1)
- mentoring (1)
- metabolic cancer therapy (1)
- metamorphosis (1)
- metasomatism (1)
- metastatic (1)
- methotrexate (1)
- methyltransferase (1)
- methyltransferases (1)
- miR-122 (1)
- miR-21 (1)
- micro data transparency (1)
- micro-Hall magnetometry (1)
- micro-longitudinal design (1)
- microdosing (1)
- microglia (1)
- micromagnetic simulations (1)
- micropalaeontology (1)
- microparticles (1)
- microsaccades (1)
- microsatellite instability (1)
- microsomal prostaglandin E2 synthase (1)
- microtubule-targeting agents (1)
- microvesicles (1)
- microwave breast imaging (1)
- middle childhood (1)
- migrants (1)
- migration (1)
- mild cognitive impairment (1)
- mindfulness (1)
- minimal information requirements (1)
- minimalinvasive Biopsie (1)
- minimally invasive biopsies (1)
- mitochondrial disease (1)
- mitosis (1)
- mixing height (1)
- mobile air quality study (1)
- model of measurement (1)
- model uncertainty (1)
- modularity of megasynthases (1)
- moisturing cream (1)
- molecular identification (1)
- molecular mechanisms (1)
- molecular motors (1)
- molecular phylogenetics (1)
- molecular simulations (1)
- molecular species discrimination (1)
- momentum (1)
- momilactone A (1)
- momilactone B (1)
- monetary policy (1)
- monetary policy surprise (1)
- monetary transmission (1)
- monitoring (1)
- monkey (1)
- monte carlo simulations (1)
- moral hazard (1)
- motor control (1)
- motor learning (1)
- mountain meteorology (1)
- mouse (1)
- mouse model (1)
- mouse neocortex (1)
- mtDNA (1)
- multidomain protein (1)
- multidrug transport (1)
- multigene analyses (1)
- multigene phylogeny (1)
- multimorbidity (1)
- multinucleated giant cells (1)
- multiple chronic conditions (1)
- multiple myeloma (1)
- multiple sclerosis (1)
- multiple traumatization (1)
- multiscale interactions (1)
- multisite cooperation (1)
- multivariate mixed model (1)
- mushroom bodies (1)
- mushroom body extrinsic neurons (1)
- myocyte enhancer factor 2 (1)
- nESI (1)
- nanofabrication (1)
- nanoparticle growth (1)
- nanostructured arrays (1)
- nanostructures (1)
- national security (1)
- nationalism (1)
- natural competence (1)
- natural experiment (1)
- natural killer T cells (1)
- natural killer cell (1)
- natural law (1)
- neo-nazi (1)
- neo-nazism (1)
- neoadjuvant chemotherapy (1)
- neoadjuvante Chemotherapie (1)
- neoepitopes (1)
- neonatal intensive care unit (1)
- neonate (1)
- neoplatonisme (1)
- neoplatonismo (1)
- neural network (1)
- neural oscillations (1)
- neuraminidase inhibitor (1)
- neuro-ophthalmological examination (1)
- neuroblastoma (1)
- neurocritical care (1)
- neurogenesis (1)
- neurological emergencies (1)
- neuromuscular function (1)
- neuronal ceroid lipofuscinosis (1)
- neurophysiology (1)
- neuropilin-1 (1)
- neuroplasticity (1)
- neuropsychology (1)
- neuroscience (1)
- new information subjects (1)
- new primers (1)
- nitro-fatty acids (1)
- nociception and pain (1)
- nomadic lifestyles (1)
- nomenclature (1)
- nominal unification (1)
- non-ST-segment elevation acute coronary syndrome (1)
- non-citizens (1)
- non-equilibrium states (1)
- nonalcoholic fatty liver disease (1)
- nonalcoholic steatohepatitis (1)
- noncovalent interactions (1)
- nondispatchability (1)
- nonviral gene delivery (1)
- novel psychoactive substance (1)
- nuclear magnetic resonance spectroscopy (1)
- nucleobases (1)
- null subjects (1)
- nursery school students (1)
- nursery schools (1)
- nursery students (1)
- nurses (1)
- obese (1)
- object tracking (1)
- observational equivalence (1)
- observational study (1)
- occupational immediate-type reactions (1)
- oil price (1)
- oligonucleotide (1)
- oligonucleotides (1)
- omega-3 fatty acids (1)
- omissions (1)
- oncogene (1)
- one health (1)
- one-child policy (1)
- online bayesian change point detection (1)
- open-access (1)
- open-source (1)
- operational risk (1)
- opposition (1)
- optimal coding (1)
- optimal power flow (1)
- option pricing (1)
- optionality (1)
- optogenetic stimulation (1)
- oral absorption (1)
- oral kallikrein inhibitor (1)
- organic charge-transfer salts (1)
- organic compounds (1)
- organic conductor (1)
- orientation behavior (1)
- orthopic liver transplantation (1)
- oscillations (1)
- oseltamivir (1)
- osmotic stress (1)
- osteoclastogenesis (1)
- osteoclasts (1)
- ostium (1)
- outcome (1)
- outcomes (1)
- outdoor education (1)
- output gap estimates (1)
- ovarian cancer (1)
- overt pronouns (1)
- oxidation state (1)
- oxygen (1)
- p+p collisions (1)
- p21-activated kinase 2 (1)
- p38 (1)
- p63 (1)
- p97 (1)
- pCREB (1)
- palbociclib (1)
- paleodiet (1)
- paleoecology (1)
- palmitoylation (1)
- papilloma (1)
- parallel file systems (1)
- parameter estimation (1)
- parameterization (1)
- parsing (1)
- parsley (1)
- part-time employment (1)
- participation as complicity (1)
- participatory governance (1)
- particle size distribution (1)
- particularism (1)
- particulate matter (1)
- pastoralism (1)
- patency (1)
- patient study (1)
- patients (1)
- paycheck frequency (1)
- paywalls (1)
- pearling transition (1)
- peer effects (1)
- peer-to-peer (1)
- pension reform (1)
- pentose phosphate pathway (1)
- perceptual closure (1)
- perceptual-cognitive expertise (1)
- percolation (1)
- pericytes (1)
- peridotite (1)
- peripheral artery disease (1)
- peripheral vascular diseases (1)
- peritoneal carcinomatosis (1)
- persistence (1)
- persistent atrial fibrillation (1)
- persisting pain (1)
- person (1)
- personalized medicine (1)
- personalized oncology (1)
- pertuzumab (1)
- pessary (1)
- phage display (1)
- pharmacology (1)
- phase III (1)
- phase coding (1)
- phase-1 (1)
- phenolics (1)
- phenylephrine (1)
- phosphate (1)
- phosphodiesterase-4 inhibitor (1)
- phospholipids/phosphatidylglycerol (1)
- phosphorylation (1)
- photo elicitation (1)
- photoaging (1)
- photochemistry (1)
- photography (1)
- photolabile protection (1)
- photopharmacology (1)
- phylogenetic community distance (1)
- phylogeny (1)
- physical activity (1)
- physical activity promotion (1)
- physical activity recommendations (1)
- physiologically based pharmacokinetic model (1)
- pictilisib (1)
- pig (1)
- piracy (1)
- pivalate (1)
- pivoloyl (1)
- plant-microbe interactions (1)
- plasminogen (1)
- plasticity (1)
- platform-switched (1)
- platforms (1)
- pleasure (1)
- pleomorphic fungi (1)
- point process (1)
- polarisation (1)
- political capacity (1)
- political economy (1)
- political epistemology (1)
- political legitimacy (1)
- political participation (1)
- political realism (1)
- poly(I:C) (1)
- poly(lactic-co-glycolic acid) (PLGA) (1)
- polydipsia (1)
- polyketide synthase (1)
- polylactic acid (PLA) (1)
- polymerase chain reaction (1)
- polypharmacy (1)
- polyphenols (1)
- polytrauma (1)
- polyuria (1)
- popliteal artery (1)
- population aging (1)
- populism (1)
- porcine (1)
- portable electronic nose (1)
- portfolio performance (1)
- post-transplantation lymphoproliferative disease (1)
- post-truth (1)
- posttranslational modification (1)
- postural control (1)
- practice theories (1)
- pre-emptive allogeneic hematopoietic stem cell transplantation (1)
- preclinical semesters (1)
- preconditioning (1)
- predictability (1)
- predictive factors (1)
- predictive modelling (1)
- predictive policing (1)
- present bias (1)
- pressurized intraperitoneal aerosol chemotherapy (PIPAC) (1)
- preterm (1)
- preterm birth (1)
- pretreatment (1)
- prevent smoking (1)
- price stability (1)
- primary cilium (1)
- primary healthcare (1)
- primary mouse proximal tubular cells (1)
- principal-agent models (1)
- privacy behavior (1)
- privacy calculus (1)
- privacy concerns (1)
- private benefits of control (1)
- procedural preferences (1)
- processing complexity (1)
- processing fluency (1)
- processing speed (1)
- processing style (1)
- progenitor cell (1)
- progesterone (1)
- prognostic factors (1)
- program transformation (1)
- programmed cell death ligand 1 (1)
- programmed cell death protein 1 (1)
- proliferation (1)
- pronominal resolution (1)
- property rights (1)
- prophylaxis (1)
- propofol anesthesia (1)
- proportionality in war (1)
- prospective memory (1)
- prostaglandin E2 (1)
- prostate cancer (1)
- protected names (1)
- protein aggregation (1)
- protein denaturation (1)
- protein engineering (1)
- protein kinase D (1)
- protein kinases (1)
- protein phosphorylation (1)
- protein tyrosine kinase (1)
- protein–protein interaction (1)
- proverbs (1)
- pruritus (1)
- psoriatic arthritis (1)
- psychological questionnaires (1)
- psychometric properties (1)
- psychosis (1)
- psychotherapy process (1)
- psychotherapy outcome research (1)
- public participation (1)
- publication (1)
- publishing (1)
- pulmonary arterial hypertension (1)
- pulmonary inflammation (1)
- pulmonary vein isolation (1)
- qPCR (1)
- qRT-PCR (1)
- qualitative research (1)
- quality control (1)
- quality of democracy (1)
- quality of life (1)
- quantitative easing (1)
- quantitative methodology (1)
- quantum criticality (1)
- quantum electrodynamics test (1)
- quantum spin frustration (1)
- quantum spin liquids (1)
- quark gluon plasma (1)
- quasiparticle expansion (1)
- quercetin (1)
- racism (1)
- radical right (1)
- radical scavenging chemicals (1)
- radicalization (1)
- radiofrequency (1)
- radiotherapy (1)
- radiotherapy resistance (1)
- random energy model (1)
- randomized controlled trial (RCT) (1)
- rangeland ecosystems (1)
- rank feedback (1)
- rare diseases (1)
- rational bias (1)
- rational learning (1)
- reading pleasure (1)
- real-world evidence (1)
- realistic geometries (1)
- recall speed (1)
- recent economic crisis (1)
- recursion (1)
- recycling pathway (1)
- redistribution (1)
- redox signalling (1)
- redox-linked proton translocation (1)
- redundancy (1)
- redundant information (1)
- reference values (1)
- regional heterogeneity (1)
- regional propagation (1)
- regression discontinuity design (1)
- regulatory T cell (1)
- rehabilitation (1)
- rejected names (1)
- relació com a principi dinàmic (1)
- relación como principio dinámico (1)
- relapsing–remitting (1)
- related party transactions (1)
- relation as dynamic principle (1)
- relative performance evaluation (1)
- relativism (1)
- relativistic fluid dynamics (1)
- relativistic heavy-ion collisions (1)
- remodeling (1)
- remote ischemic preconditioning (1)
- remote sensing (1)
- renal cell cancer (1)
- renal cell carcinoma (1)
- renal failure (1)
- renal ischemia reperfusion injury (1)
- renewable energy (1)
- repeatability (1)
- reproductive isolation (1)
- repurchases (1)
- research consortium (1)
- resilience (1)
- resource boom (1)
- respirasomes (1)
- respiratory chain supercomplexes (1)
- respiratory complex I (1)
- responsibility (1)
- restenosis (1)
- restrictive atrial communication (1)
- retina (1)
- retinoic acid-related orphan receptor gamma t (1)
- retirement (1)
- retirement age (1)
- reweighting (1)
- rhodocetin-αβ (1)
- rhythm (1)
- ribociclib (1)
- ribosomal proteins (1)
- ribosome biogenesis (1)
- ribosome quality control (1)
- rice husk (1)
- right to life (1)
- rigor (1)
- riots (1)
- risk assessment (1)
- risk culture (1)
- robophysics (1)
- roflumilast (1)
- rootletin (1)
- roots (1)
- rural health program (1)
- rural-urban migration (1)
- saliva (1)
- satellite rainfall estimates (1)
- scalar implicature (1)
- scanning laser Doppler vibrometry (1)
- scarring effects (1)
- scheduling (1)
- school-based prevention (1)
- schools (1)
- science of sciences (1)
- scientometrics (1)
- scientometry (1)
- screening (1)
- screening routine (1)
- screening system (1)
- secondary transport (1)
- secretion (1)
- securities regulation (1)
- security-constrained optimal power flow (1)
- sedentarism (1)
- selection (1)
- selective attention (1)
- selective mutism, (1)
- self-interest (1)
- self-organized locomotion (1)
- semen (1)
- sensitization (1)
- sensorimotor loop (1)
- sensorimotor oscillations (1)
- sensory acquisition (1)
- sequential ALK-inhibitor therapy (1)
- sexual ornament (1)
- shedding (1)
- shell ginger (1)
- shortage of family doctors (1)
- siRNA (1)
- signal processing (1)
- silence interfering RNA (1)
- single crystal growth (1)
- sirtuin1 (1)
- sirtuins (1)
- six new taxa (1)
- skeletal muscle (1)
- skill-level (1)
- slabs (1)
- slope winds (1)
- slums (1)
- smoking (1)
- smoking cessation (1)
- smut fung (1)
- social investment (1)
- social class (1)
- social identity (1)
- social interactions (1)
- social security (1)
- social threat sensitivity (1)
- socialist education (1)
- soil VOCs (1)
- solution-state NMR (1)
- solvent displacement (1)
- somatostatin interneurons (1)
- sonidegib (1)
- soraphen (1)
- spatial (1)
- spatial exclusion (1)
- spatial filtering (1)
- spatial precision (1)
- speciation (1)
- species complex (1)
- species discrimination (1)
- speededness (1)
- sphinganine 1-phosphate (1)
- sphingosine kinase 1 (1)
- spike timing (1)
- spinster homology protein 2 (Spns2) (1)
- spirochetes (1)
- squamous cell carcinoma (1)
- stable convergence (1)
- stacking (1)
- staleness (1)
- standard setting (1)
- standard value (1)
- standardization (1)
- state-contingent contracts (1)
- statelessness (1)
- stem cell niche (1)
- stem cells (1)
- stenosis (1)
- stenosis quantification (1)
- steppe ecosystem (1)
- sterol regulatory element binding protein-2 (1)
- stochastic model (1)
- stochastic volatility (1)
- stock returns (1)
- stockholding (1)
- stocks (1)
- storage (1)
- storage rings (1)
- strangeness (1)
- stress test (1)
- striatum (1)
- stroke (1)
- strong Coulomb field (1)
- structural biology (1)
- structural biology and molecular biophysics (1)
- structural health monitoring (1)
- structural validity (1)
- structure-based reverse vaccinology (1)
- studies (1)
- subcutaneous immunotherapy (1)
- sublingual immunotherapy (1)
- subsistence agriculture (1)
- subtomogram averaging (1)
- subventricular zone (1)
- sugar transport assays (1)
- sugar transport inhibitors (1)
- superficial femoral artery (1)
- superresolution microscopy (1)
- supervisory intervention (1)
- suppletion (1)
- support vector machine (1)
- supramolecular chemistry (1)
- surface science (1)
- surgery (1)
- surveillance (1)
- synaptic scaling (1)
- synaptic vesicles (1)
- syncope (1)
- synergy (1)
- syntactic dependencies (1)
- syntax (1)
- synthetic riboswitches (1)
- systematics (1)
- systemic risk (1)
- talent, learning (1)
- target (1)
- taxation (1)
- taxonomy (1)
- teaching skills (1)
- tear (1)
- technological frames (1)
- technological progess (1)
- technological stasis (1)
- technologies (1)
- temozolomide (1)
- temperature (1)
- temperature adaptation (1)
- temporality (1)
- temsirolimus (1)
- terapia cognitivo conductual (1)
- test anxiety (1)
- testicular cancer (1)
- tetracycline (1)
- tetracycline aptamer (1)
- tetrahydrobiopterin (1)
- text analysis (1)
- theatre (1)
- theory (1)
- therapeutic alliance (1)
- thermal expansion (1)
- thermophile (1)
- three-dimensional nanostructures (1)
- thymus (1)
- time inconsistency (1)
- time-delayed embedding (1)
- time-limit effect (1)
- titanium (1)
- titanium particles (1)
- tobacco (1)
- tobacco cessation (1)
- tomography (1)
- tomosynthesis (1)
- top-down processing (1)
- topic modelling (1)
- topical agent (1)
- topography filtering (1)
- total events (1)
- total flavonoids (1)
- total phenols (1)
- toxicity (1)
- tracking (1)
- trade wind clouds (1)
- trademark law (1)
- traffic emissions (1)
- trans/cis ratio (1)
- transcatheter aortic valve replacement (1)
- transcranial magnetic stimulation (1)
- transcriptome analysis (1)
- transcriptomics (1)
- transfemoral (1)
- transgelin (1)
- transgenic mice (1)
- transient elastography (1)
- transketolase-like protein 1 (1)
- translation (1)
- translational cancer research (1)
- transliteration (1)
- transnational democratic inclusion (1)
- transport theory (1)
- transposition (1)
- trastorno borderline de personalidad (1)
- trastuzumab (1)
- trauma acumulado (1)
- traumatización múltiple (1)
- treatment/therapy (1)
- tree rings (1)
- triacylglycerides (1)
- triterpene acid (1)
- tropical conservation (1)
- tropical forests (1)
- tropical fungi (1)
- truth (1)
- tubular regeneration (1)
- tumor metabolism (1)
- tumor-infiltrating lymphocytes (1)
- tunneling (1)
- tutur text (1)
- type B (1)
- type IV pili (1)
- typology (1)
- ubiquitin (1)
- ultrashort laser pulses (1)
- ultrasound (1)
- uncertainty (1)
- unemployment insurance (1)
- unique information (1)
- unit commitment; (1)
- unit nomenclature (1)
- universalism (1)
- university teachers (1)
- updating (1)
- upper gastrointestinal cancer (1)
- urban governance (1)
- urban sociology (1)
- vaccination rates (1)
- vaccine acceptance (1)
- vaccine trial (1)
- vanadium (1)
- variable renewable energy sources (1)
- vascular biology/endothelial cells (1)
- vascular calcification (1)
- vascular endothelial growth factor receptor 2 (1)
- vascular smooth muscle cells (1)
- vasculogenic mimicry (1)
- vasoconstriction (1)
- vasodilation (1)
- vasopressin (1)
- vectored vaccine (1)
- ventilation modes (1)
- ventral striatum (1)
- ventriculoperitoneal shunt (1)
- venture funding (1)
- verb cluster (1)
- verification (1)
- vesicular glutamate transporter 2 (1)
- vessel-associated mural cells (1)
- viral dynamics (1)
- viral immune escape (1)
- virus (1)
- virus-like particles (1)
- vision (1)
- vismodegib (1)
- vismodegib (GDC-0449) (1)
- visual cortex (1)
- visuo-spatial attention (1)
- vitamin D (1)
- vitamin D receptor (1)
- volatility of volatility (1)
- volleyball (1)
- voltage-gated proton channels (1)
- voltage-sensing domains (1)
- voltage-sensing phosphatases (1)
- voucherless taxa (1)
- water contact angles (1)
- wear (1)
- weighted constraints (1)
- welfare (1)
- welfare regimes (1)
- welfare state (1)
- welfare state attitudes (1)
- wh-question (1)
- white-matter (1)
- whole-cell recordings (1)
- wild animals (1)
- wildlife mobility (1)
- willingness to participate (1)
- winner-loser (1)
- within-host viral modelling (1)
- women radicalization (1)
- word order (1)
- working memory (1)
- working memory training (1)
- working memory updating; (1)
- wound healing (1)
- xAPI (1)
- yield optimization (1)
- zero lower bound (1)
- zero returns (1)
- ß-D-glucan (1)
- Λc⁺ (1)
- α-mannosidosis (1)
- 创伤 (1)
- 可行性 (1)
- 多重创伤 (1)
- 心理治疗结果研究 (1)
- 指标创伤 (1)
- 标准A (1)
- 童年性虐待 (1)
- 累 积创伤 (1)
- 认知行为治疗 (1)
- 边缘性人格障碍 (1)
Institute
- Medizin (456)
- Physik (218)
- Wirtschaftswissenschaften (131)
- Frankfurt Institute for Advanced Studies (FIAS) (96)
- Sustainable Architecture for Finance in Europe (SAFE) (95)
- Center for Financial Studies (CFS) (94)
- Biowissenschaften (90)
- Informatik (69)
- House of Finance (HoF) (62)
- Biochemie und Chemie (58)
Background: Current approved drugs for Alzheimer’s disease (AD) only attenuate symptoms, but do not cure the disease. The pirinixic acid derivate MH84 has been characterized as a dual gamma-secretase/proliferator activated receptor gamma (PPARγ) modulator in vitro. Pharmacokinetic studies in mice showed that MH84 is bioavailable after oral administration and reaches the brain. We recently demonstrated that MH84 improved mitochondrial dysfunction in a cellular model of AD. In the present study, we extended the pharmacological characterization of MH84 to 3-month-old Thy-1 AβPPSL mice (harboring the Swedish and London mutation in human amyloid precursor protein (APP)) which are characterized by enhanced AβPP processing and cerebral mitochondrial dysfunction, representing a mouse model of early AD.
Methods: Three-month-old Thy-1 AβPPSL mice received 12 mg/kg b.w. MH84 by oral gavage once a day for 21 days. Mitochondrial respiration was analyzed in isolated brain mitochondria, and mitochondrial membrane potential and ATP levels were determined in dissociated brain cells. Citrate synthase (CS) activity was determined in brain tissues and MitoTracker Green fluorescence was measured in HEK293-AβPPwt and HEK293-AβPPsw cells. Soluble Aβ1–40 and Aβ1–42 levels were determined using ELISA. Western blot analysis and qRT-PCR were used to measure protein and mRNA levels, respectively.
Results: MH84 reduced cerebral levels of the β-secretase-related C99 peptide and of Aβ40 levels. Mitochondrial dysfunction was ameliorated by restoring complex IV (cytochrome-c oxidase) respiration, mitochondrial membrane potential, and levels of ATP. Induction of PPARγ coactivator-1α (PGC-1α) mRNA and protein expression was identified as a possible mode of action that leads to increased mitochondrial mass as indicated by enhanced CS activity, OXPHOS levels, and MitoTracker Green fluorescence.
Conclusions: MH84 modulates β-secretase processing of APP and improves mitochondrial dysfunction by a PGC-1α-dependent mechanism. Thus, MH84 seems to be a new promising therapeutic agent with approved in-vivo activity for the treatment of AD.
Damage control resuscitation may lead to postoperative intra-abdominal hypertension or abdominal compartment syndrome. These conditions may result in a vicious, self-perpetuating cycle leading to severe physiologic derangements and multiorgan failure unless interrupted by abdominal (surgical or other) decompression. Further, in some clinical situations, the abdomen cannot be closed due to the visceral edema, the inability to control the compelling source of infection or the necessity to re-explore (as a “planned second-look” laparotomy) or complete previously initiated damage control procedures or in cases of abdominal wall disruption. The open abdomen in trauma and non-trauma patients has been proposed to be effective in preventing or treating deranged physiology in patients with severe injuries or critical illness when no other perceived options exist. Its use, however, remains controversial as it is resource consuming and represents a non-anatomic situation with the potential for severe adverse effects. Its use, therefore, should only be considered in patients who would most benefit from it. Abdominal fascia-to-fascia closure should be done as soon as the patient can physiologically tolerate it. All precautions to minimize complications should be implemented.
The contribution of upper body movements to dynamic balance regulation during challenged locomotion
(2018)
Recent studies suggest that in addition to movements between ankle and hip joints, movements of the upper body, in particular of the arms, also significantly contribute to postural control. In line with these suggestions, we analyzed regulatory movements of upper and lower body joints supporting dynamic balance regulation during challenged locomotion. The participants walked over three beams of varying width and under three different verbally conveyed restrictions of arm posture, to control the potential influence of arm movements on the performance: The participants walked with their arms stretched out perpendicularly in the frontal plane, spontaneously, i.e., without restrictions to the arm movements, and with their hands on their thighs. After applying an inverse-dynamics analysis to the measured joint kinematics, we investigated the contribution of upper and lower body joints to balance regulation in terms of torque amplitude and variation. On the condition with the hands on the thighs, the contribution of the upper body remains significantly lower than the contribution of the lower body irrespective of beam widths. For spontaneous arm movements and for outstretched arms we find that the upper body (including the arms) contributes to the balancing to a similar extent as the lower body. Moreover, when the task becomes more difficult, i.e., for narrower beam widths, the contribution of the upper body increases, while the contribution of the lower body remains nearly constant. These findings lend further support to the hypothetical existence of an "upper body strategy" complementing the ankle and hip strategies especially during challenging dynamic balance tasks.
The new edition of the 2016 World Health Organization (WHO) classification system for tumors of the hematopoietic and lymphoid tissues was published in September 2017. Under the category of myeloproliferative neoplasms (MPNs), the revised document includes seven subcategories: chronic myeloid leukemia, chronic neutrophilic leukemia, polycythemia vera (PV), primary myelofibrosis (PMF), essential thrombocythemia (ET), chronic eosinophilic leukemia-not otherwise specified and MPN, unclassifiable (MPN-U); of note, mastocytosis is no longer classified under the MPN category. In the current review, we focus on the diagnostic criteria for JAK2/CALR/MPL mutation-related MPNs: PV, ET, and PMF. In this regard, the 2016 changes were aimed at facilitating the distinction between masked PV and JAK2-mutated ET and between prefibrotic/early and overtly fibrotic PMF. In the current communication, we (i) provide practically useful resource tables and graphs on the new diagnostic criteria including outcome, (ii) elaborate on the rationale for the 2016 changes, (iii) discuss the complementary role of mutation screening, (iv) address ongoing controversies and propose solutions, (v) attend to the challenges of applying WHO criteria in routine clinical practice, and (vi) outline future directions from the perspectives of the clinical pathologist.
Background: Rare diseases are, by definition, very serious and chronic diseases with a high negative impact on quality of life. Approximately 350 million people worldwide live with rare diseases. The resulting high disease burden triggers health information search, but helpful, high-quality, and up-to-date information is often hard to find. Therefore, the improvement of health information provision has been integrated in many national plans for rare diseases, discussing the telephone as one access option. In this context, this study examines the need for a telephone service offering information for people affected by rare diseases, their relatives, and physicians.
Methods: In total, 107 individuals participated in a qualitative interview study conducted in Germany. Sixty-eight individuals suffering from a rare disease or related to somebody with rare diseases and 39 health care professionals took part. Individual interviews were conducted using a standardized semi-structured questionnaire. Interviews were analysed using the qualitative content analysis, triangulating patients, relatives, and health care professionals. The fulfilment of qualitative data processing standards has been controlled for.
Results: Out of 68 patients and relatives and 39 physicians, 52 and 18, respectively, advocated for the establishment of a rare diseases telephone service. Interviewees expected a helpline to include expert staffing, personal contact, good availability, low technical barriers, medical and psychosocial topics of counselling, guidance in reducing information chaos, and referrals. Health care professionals highlighted the importance of medical topics of counselling—in particular, differential diagnostics—and referrals.
Conclusions: Therefore, the need for a national rare diseases helpline was confirmed in this study. Due to limited financial resources, existing offers should be adapted in a stepwise procedure in accordance with the identified attributes.
Background: The Catechol-O-methyltransferase (COMT) represents the key enzyme in catecholamine degradation. Recent studies suggest that the COMT rs4680 polymorphism is associated with the response to endogenous and exogenous catecholamines. There are, however, conflicting data regarding the COMT Met/Met phenotype being associated with an increased risk of acute kidney injury (AKI) after cardiac surgery. The aim of the current study is to prospectively investigate the impact of the COMT rs4680 polymorphism on the incidence of AKI in patients undergoing cardiac surgery.
Methods: In this prospective single center cohort study consecutive patients hospitalized for elective cardiac surgery including cardiopulmonary-bypass (CPB) were screened for participation. Demographic clinical data, blood, urine and tissue samples were collected at predefined time points throughout the clinical stay. AKI was defined according to recent recommendations of the Kidney Disease Improving Global Outcome (KDIGO) group. Genetic analysis was performed after patient enrolment was completed.
Results: Between April and December 2014, 150 patients were recruited. The COMT genotypes were distributed as follows: Val/Met 48.7%, Met/Met 29.3%, Val/Val 21.3%. No significant differences were found for demography, comorbidities, or operative strategy according to the underlying COMT genotype. AKI occurred in 35 patients (23.5%) of the total cohort, and no differences were evident between the COMT genotypes (20.5% Met/Met, 24.7% Val/Met, 25.0% Val/Val, p = 0.66). There were also no differences in the post-operative period, including ICU or in-hospital stay.
Conclusions: We did not find statistically significant variations in the risk for postoperative AKI, length of ICU or in-hospital stay according to the underlying COMT genotype.
This paper presents three acceptability experiments investigating German verb-final clauses in order to explore possible sources of sentence complexity during human parsing. The point of departure was De Vries et al.'s (2011) generalization that sentences with three or more crossed or nested dependencies are too complex for being processed by the human parsing mechanism without difficulties. This generalization is partially based on findings from Bach et al. (1986) concerning the acceptability of complex verb clusters in German and Dutch. The first experiment tests this generalization by comparing two sentence types: (i) sentences with three nested dependencies within a single clause that contains three verbs in a complex verb cluster; (ii) sentences with four nested dependencies distributed across two embedded clauses, one center-embedded within the other, each containing a two-verb cluster. The results show that sentences with four nested dependencies are judged as acceptable as control sentences with only two nested dependencies, whereas sentences with three nested dependencies are judged as only marginally acceptable. This argues against De Vries et al.'s (2011) claim that the human parser can process no more than two nested dependencies. The results are used to refine the Verb-Cluster Complexity Hypothesis of Bader and Schmid (2009a). The second and the third experiment investigate sentences with four nested dependencies in more detail in order to explore alternative sources of sentence complexity: the number of predicted heads to be held in working memory (storage cost in terms of the Dependency Locality Theory [DLT], Gibson, 2000) and the length of the involved dependencies (integration cost in terms of the DLT). Experiment 2 investigates sentences for which storage cost and integration cost make conflicting predictions. The results show that storage cost outweighs integration cost. Experiment 3 shows that increasing integration cost in sentences with two degrees of center embedding leads to decreased acceptability. Taken together, the results argue in favor of a multifactorial account of the limitations on center embedding in natural languages.
The UDP-glucose ceramide glycosyltransferase (UGCG) is a key enzyme in the sphingolipid metabolism by generating glucosylceramide (GlcCer), the precursor for all glycosphingolipids (GSL), which are essential for proper cell function. Interestingly, the UGCG is also overexpressed in several cancer types and correlates with multidrug resistance protein 1 (MDR1) gene expression. This membrane protein is responsible for efflux of toxic substances and protects cancer cells from cell damage through chemotherapeutic agents. Studies showed a connection between UGCG and MDR1 overexpression and multidrug resistance development, but the precise underlying mechanisms are unknown. Here, we give an overview about the UGCG and its connection to MDR1 in multidrug resistant cells. Furthermore, we focus on UGCG transcriptional regulation, the impact of UGCG on cellular signaling pathways and the effect of UGCG and MDR1 on the lipid composition of membranes and how this could influence multidrug resistance development. To our knowledge, this is the first review presenting an overview about UGCG with focus on the relationship to MDR1 in the process of multidrug resistance development.
Background: Worldwide, the number of recorded human hantavirus infections as well as the number of affected countries is on the rise. In Europe, most human hantavirus infections are caused by the Puumala virus (PUUV), with bank voles (Myodes glareolus) as reservoir hosts. Generally, infection outbreaks have been related to environmental conditions, particularly climatic conditions, food supply for the reservoir species and land use. However, although attempts have been made, the insufficient availability of environmental data is often hampering accurate temporal and spatially explicit models of human hantavirus infections.
Methods: In the present study, dynamics of human PUUV infections between 2001 and 2015 were explored using ArcGIS in order to identify spatio-temporal patterns.
Results: Percentage cover of forest area was identified as an important factor for the spatial pattern, whereas beech mast was found explaining temporal patterns of human PUUV infections in Germany. High numbers of infections were recorded in 2007, 2010 and 2012 and areas with highest records were located in Baden-Wuerttemberg (southwest Germany) and North Rhine-Westphalia (western Germany).
Conclusion: More reliable data on reservoir host distribution, pathogen verification as well as an increased awareness of physicians are some of the factors that should improve future human infection risk assessments in Germany.
Background: As ectothermic animals, temperature influences insects in almost every aspect. The potential disease spreading Asian bush mosquito (Aedes japonicus japonicus) is native to temperate East Asia but invasive in several parts of the world. We report on the previously poorly understood temperature-dependence of its life history under laboratory conditions to understand invasion processes and to model temperature niches.
Results: To evaluate winter survival, eggs were exposed between 1 day and 14 days to low temperatures (5 °C, 0 °C, -5 °C and -9 °C). Hatching success was drastically decreased after exposure to 0 °C and -5 °C, and the minimal hatching success of 0% was reached at -9 °C after two days. We then exposed larvae to 14 temperatures and assessed their life trait parameters. Larval survival to adulthood was only possible between 10 °C and 31 °C. Based on this, we modelled the optimal (25 °C), minimal (7 °C) and maximal (31 °C) temperature for cumulative female survival. The time to adult emergence ranges from 12 days to 58 days depending on temperature. We used an age-at-emergence-temperature model to calculate the number of potential generations per year for the Asian bush mosquito in Germany with an average of 4.72 potential generations. At lower temperatures, individuals grew larger than at higher temperatures with female R1 length ranging from 3.04 ± 0.1 mm at 31 °C to 4.26 ± 0.2 mm at 15 °C.
Conclusions: Reduced egg hatch after exposure to sub-zero temperatures prohibits the establishment of the Asian bush mosquito in large parts of Germany. Larval overwintering is not possible at temperature ≤ 5 °C. The many potential generations displayed per year may contribute to the species’ invasion success. This study on the thermal ecology of the Asian bush mosquito adds to our knowledge on the temperature dependence of the species and data could be incorporated in epidemiological and population dynamic modelling.
Background: The treatment of patients with multiple trauma including blunt chest/thoracic trauma (TxT) and hemorrhagic shock (H) is still challenging. Numerous studies show detrimental consequences of TxT and HS resulting in strong inflammatory changes, organ injury and mortality. Additionally, the reperfusion (R) phase plays a key role in triggering inflammation and worsening outcome. Ethyl pyruvate (EP), a stable lipophilic ester, has anti-inflammatory properties. Here, the influence of EP on the inflammatory reaction and liver injury in a double hit model of TxT and H/R in rats was explored.
Methods: Female Lewis rats were subjected to TxT followed by hemorrhage/H (60 min, 35±3 mm Hg) and resuscitation/R (TxT+H/R). Reperfusion was performed by either Ringer`s lactated solution (RL) alone or RL supplemented with EP (50 mg/kg). Sham animals underwent all surgical procedures without TxT+H/R. After 2h, blood and liver tissue were collected for analyses, and survival was assessed after 24h.
Results: Resuscitation with EP significantly improved haemoglobin levels and base excess recovery compared with controls after TxT+H/R, respectively (p<0.05). TxT+H/R-induced significant increase in alanine aminotransferase levels and liver injury were attenuated by EP compared with controls (p<0.05). Local inflammation as shown by increased gene expression of IL-6 and ICAM-1, enhanced ICAM-1 and HMGB1 protein expression and infiltration of the liver with neutrophils were also significantly attenuated by EP compared with controls after TxT+H/R (p<0.05). EP significantly reduced TxT+H/R-induced p65 activation in liver tissue. Survival rates improved by EP from 50% to 70% after TxT+H/R.
Conclusions: These data support the concept that the pronounced local pro-inflammatory response in the liver after blunt chest trauma and hemorrhagic shock is associated with NF-κB. In particular, the beneficial anti-inflammatory effects of ethyl pyruvate seem to be regulated by the HMGB1/NF-κB axis in the liver, thereby, restraining inflammatory responses and liver injury after double hit trauma in the rat.
The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2
(2018)
Impaired or excessive growth of endothelial cells contributes to several diseases. However, the functional involvement of regulatory long non-coding RNAs in these processes is not well defined. Here, we show that the long non-coding antisense transcript of GATA6 (GATA6-AS) interacts with the epigenetic regulator LOXL2 to regulate endothelial gene expression via changes in histone methylation. Using RNA deep sequencing, we find that GATA6-AS is upregulated in endothelial cells during hypoxia. Silencing of GATA6-AS diminishes TGF-β2-induced endothelial–mesenchymal transition in vitro and promotes formation of blood vessels in mice. We identify LOXL2, known to remove activating H3K4me3 chromatin marks, as a GATA6-AS-associated protein, and reveal a set of angiogenesis-related genes that are inversely regulated by LOXL2 and GATA6-AS silencing. As GATA6-AS silencing reduces H3K4me3 methylation of two of these genes, periostin and cyclooxygenase-2, we conclude that GATA6-AS acts as negative regulator of nuclear LOXL2 function.
Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome
(2018)
The p63 gene encodes a master regulator of epidermal commitment, development, and differentiation. Heterozygous mutations in the C-terminal domain of the p63 gene can cause ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome, a life-threatening disorder characterized by skin fragility and severe, long-lasting skin erosions. Despite deep knowledge of p63 functions, little is known about mechanisms underlying disease pathology and possible treatments. Here, we show that multiple AEC-associated p63 mutations, but not those causative of other diseases, lead to thermodynamic protein destabilization, misfolding, and aggregation, similar to the known p53 gain-of-function mutants found in cancer. AEC mutant proteins exhibit impaired DNA binding and transcriptional activity, leading to dominant negative effects due to coaggregation with wild-type p63 and p73. Importantly, p63 aggregation occurs also in a conditional knock-in mouse model for the disorder, in which the misfolded p63 mutant protein leads to severe epidermal defects. Variants of p63 that abolish aggregation of the mutant proteins are able to rescue p63’s transcriptional function in reporter assays as well as in a human fibroblast-to-keratinocyte conversion assay. Our studies reveal that AEC syndrome is a protein aggregation disorder and opens avenues for therapeutic intervention.
Background: Recurrent airway infections are common in patients with Down’s syndrome (DS). Hence, ruling out Cystic Fibrosis (CF) in these patients is often required. In the past, the value of sweat testing – the gold standard to diagnose CF – has been questioned in DS as false positive results have been reported. However, these reports are based on measurements of sweat osmolality or sodium concentrations, not chloride concentrations. This study analyses sweat secretion rate and chloride concentration in sweat samples of patients with DS in comparison to healthy controls.
Methods: We assessed sweat samples in 16 patients with DS and 16 healthy controls regarding sweat secretion rate (SSR) and sweat chloride concentration.
Results: All measured chloride concentrations were within the normal range. The chloride concentrations were slightly, but not significantly lower in patients with DS (15,54 mmol/l (±4,47)) compared to healthy controls (18,31 mmol/l (±10,12)). While no gender gap in chloride concentration could be found, chloride concentration increased with age in both groups.
Insufficient sweat was collected in 2 females with DS (12.5% of the study group) but not in an individual of the control group. A significant lower sweat secretion rate was found in the DS group (27,6 μl/30 min (± 12,18)) compared to the control group (42,7 μl/30 min (± 21,22)). In a sub-analysis, female patients produced significantly less sweat (20,8 ± 10,6 μl/30 min) than male patients with DS (36,4 ± 7,8 μl/30 min), which accounts for the difference between patients and controls. Furthermore, while the sweating secretion rate increased with age in the control group, it did not do so in the DS group. Once again this was due to female patients with DS, who did not show a significant increase of sweat secretion rate with age.
Conclusions: Sweat chloride concentrations were within the normal range in patients with DS and therefore seem to be a reliable tool for testing for CF in these patients. Interestingly, we found a reduced sweat secretion rate in the DS group. Whether the last one has a functional and clinical counterpart, possibly due to a disturbed thermoregulation in DS patients, requires further investigation.
Coordination of circuit breakers? Volume migration and volatility spillover in fragmented markets
(2018)
We study circuit breakers in a fragmented, multi-market environment and investigate whether a coordination of circuit breakers is necessary to ensure their effectiveness. In doing so, we analyze 2,337 volatility interruptions on Deutsche Boerse and research whether a volume migration and an accompanying volatility spillover to alternative venues that continue trading can be observed. Different to prevailing theoretical rationale, trading volume on alternative venues significantly decreases during circuit breakers on the main market and we do not find any evidence for volatility spillover. Moreover, we show that the market share of the main market increases sharply during a circuit breaker. Surprisingly, this is amplified with increasing levels of fragmentation. We identify high-frequency trading as a major reason for the vanishing trading activity on the alternative venues and give empirical evidence that a coordination of circuit breakers is not essential for their effectiveness as long as market participants shift to the dominant venue during market stress.
We investigate different designs of circuit breakers implemented on European trading venues and examine their effectiveness to manage excess volatility and to preserve liquidity. Specifically, we empirically analyze volatility and liquidity around volatility interruptions implemented on the German and Spanish stock market which differ regarding specific design parameters. We find that volatility interruptions in general significantly decrease volatility in the post interruption phase. Unfortunately, this decrease in volatility comes at the cost of decreased liquidity. Regarding design parameters, we find tighter price ranges and shorter durations to support volatility interruptions in achieving their goals.
A primordial state of matter consisting of free quarks and gluons that existed in the early universe a few microseconds after the Big Bang is also expected to form in high-energy heavy-ion collisions. Determining the equation of state (EoS) of such a primordial matter is the ultimate goal of high-energy heavy-ion experiments. Here we use supervised learning with a deep convolutional neural network to identify the EoS employed in the relativistic hydrodynamic simulations of heavy ion collisions. High-level correlations of particle spectra in transverse momentum and azimuthal angle learned by the network act as an effective EoS-meter in deciphering the nature of the phase transition in quantum chromodynamics. Such EoS-meter is model-independent and insensitive to other simulation inputs including the initial conditions for hydrodynamic simulations.
Background: Agrocybe aegerita is an agaricomycete fungus with typical mushroom features, which is commercially cultivated for its culinary use. In nature, it is a saprotrophic or facultative pathogenic fungus causing a white-rot of hardwood in forests of warm and mild climate. The ease of cultivation and fructification on solidified media as well as its archetypal mushroom fruit body morphology render A. aegerita a well-suited model for investigating mushroom developmental biology.
Results: Here, the genome of the species is reported and analysed with respect to carbohydrate active genes and genes known to play a role during fruit body formation. In terms of fruit body development, our analyses revealed a conserved repertoire of fruiting-related genes, which corresponds well to the archetypal fruit body morphology of this mushroom. For some genes involved in fruit body formation, paralogisation was observed, but not all fruit body maturation-associated genes known from other agaricomycetes seem to be conserved in the genome sequence of A. aegerita. In terms of lytic enzymes, our analyses suggest a versatile arsenal of biopolymer-degrading enzymes that likely account for the flexible life style of this species. Regarding the amount of genes encoding CAZymes relevant for lignin degradation, A. aegerita shows more similarity to white-rot fungi than to litter decomposers, including 18 genes coding for unspecific peroxygenases and three dye-decolourising peroxidase genes expanding its lignocellulolytic machinery.
Conclusions: The genome resource will be useful for developing strategies towards genetic manipulation of A. aegerita, which will subsequently allow functional genetics approaches to elucidate fundamentals of fruiting and vegetative growth including lignocellulolysis.
Background: Von Willebrand disease (VWD) is the most common inherent bleeding disorder. Gingival bleeding is a frequently reported symptom of VWD. However, gingival bleeding is also a leading symptom of plaque-induced gingivitis and untreated periodontal disease. In type 1 VWD gingival bleeding was not increased compared to controls. Thus, this study evaluated whether type 2 and 3 VWD determines an increased susceptibility to gingival bleeding in response to the oral biofilm.
Methods: Twenty-four cases and 24 controls matched for age, sex, periodontal diagnosis, number of teeth and smoking were examined hematologically (VWF antigen, VWF activity, factor VIII activity) and periodontally (Gingival Bleeding Index [GBI]), bleeding on probing [BOP], Plaque Control Record [PCR], periodontal inflamed surface area [PISA], vertical probing attachment level).
Results: BOP (VWD: 14.5±10.1%; controls: 12.3±5.3%; p = 0.542) and GBI (VWD: 10.5±9.9%; controls: 8.8±4.8%; p = 0.852) were similar for VWD and controls. Multiple regressions identified female sex, HbA1c, PCR and PISA to be associated with BOP. HbA1c and PCR were associated with GBI. Number of remaining teeth was negatively correlated with BOP and GBI.
Conclusion: Type 2 and 3 VWD are not associated with a more pronounced inflammatory response to the oral biofilm in terms of BOP and GBI.
Stimulation of renal collecting duct principal cells with antidiuretic hormone (arginine-vasopressin, AVP) results in inhibition of the small GTPase RhoA and the enrichment of the water channel aquaporin-2 (AQP2) in the plasma membrane. The membrane insertion facilitates water reabsorption from primary urine and fine-tuning of body water homeostasis. Rho guanine nucleotide exchange factors (GEFs) interact with RhoA, catalyze the exchange of GDP for GTP and thereby activate the GTPase. However, GEFs involved in the control of AQP2 in renal principal cells are unknown. The A-kinase anchoring protein, AKAP-Lbc, possesses GEF activity, specifically activates RhoA, and is expressed in primary renal inner medullary collecting duct principal (IMCD) cells. Through screening of 18,431 small molecules and synthesis of a focused library around one of the hits, we identified an inhibitor of the interaction of AKAP-Lbc and RhoA. This molecule, Scaff10-8, bound to RhoA, inhibited the AKAP-Lbc-mediated RhoA activation but did not interfere with RhoA activation through other GEFs or activities of other members of the Rho family of small GTPases, Rac1 and Cdc42. Scaff10-8 promoted the redistribution of AQP2 from intracellular vesicles to the periphery of IMCD cells. Thus, our data demonstrate an involvement of AKAP-Lbc-mediated RhoA activation in the control of AQP2 trafficking.
Background: Published estimates of mortality and progression to AIDS as children with HIV approach adulthood are limited. We describe rates and risk factors for death and AIDS-defining events in children and adolescents after initiation of combination antiretroviral therapy (cART) in 17 middle- and high-income countries, including some in Western and Central Europe (W&CE), Eastern Europe (Russia and Ukraine), and Thailand.
Methods and findings: Children with perinatal HIV aged <18 years initiating cART were followed until their 21st birthday, transfer to adult care, death, loss to follow-up, or last visit up until 31 December 2013. Rates of death and first AIDS-defining events were calculated. Baseline and time-updated risk factors for early/late (≤/>6 months of cART) death and progression to AIDS were assessed. Of 3,526 children included, 32% were from the United Kingdom or Ireland, 30% from elsewhere in W&CE, 18% from Russia or Ukraine, and 20% from Thailand. At cART initiation, median age was 5.2 (IQR 1.4–9.3) years; 35% of children aged <5 years had a CD4 lymphocyte percentage <15% in 1997–2003, which fell to 15% of children in 2011 onwards (p < 0.001). Similarly, 53% and 18% of children ≥5 years had a CD4 count <200 cells/mm3 in 1997–2003 and in 2011 onwards, respectively (p < 0.001). Median follow-up was 5.6 (2.9–8.7) years. Of 94 deaths and 237 first AIDS-defining events, 43 (46%) and 100 (42%) were within 6 months of initiating cART, respectively. Multivariable predictors of early death were: being in the first year of life; residence in Russia, Ukraine, or Thailand; AIDS at cART start; initiating cART on a nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimen; severe immune suppression; and low BMI-for-age z-score. Current severe immune suppression, low current BMI-for-age z-score, and current viral load >400 c/mL predicted late death. Predictors of early and late progression to AIDS were similar. Study limitations include incomplete recording of US Centers for Disease Control (CDC) disease stage B events and serious adverse events in some countries; events that were distributed over a long time period, and that we lacked power to analyse trends in patterns and causes of death over time.
Conclusions: In our study, 3,526 children and adolescents with perinatal HIV infection initiated antiretroviral therapy (ART) in countries in Europe and Thailand. We observed that over 40% of deaths occurred ≤6 months after cART initiation. Greater early mortality risk in infants, as compared to older children, and in Russia, Ukraine, or Thailand as compared to W&CE, raises concern. Current severe immune suppression, being underweight, and unsuppressed viral load were associated with a higher risk of death at >6 months after initiation of cART.
In optogenetics, rhodopsins were established as light-driven tools to manipulate neuronal activity. However, during long-term photostimulation using channelrhodopsin (ChR), desensitization can reduce effects. Furthermore, requirement for continuous presence of the chromophore all-trans retinal (ATR) in model systems lacking sufficient endogenous concentrations limits its applicability. We tested known, and engineered and characterized new variants of de- and hyperpolarizing rhodopsins in Caenorhabditis elegans. ChR2 variants combined previously described point mutations that may synergize to enable prolonged stimulation. Following brief light pulses ChR2(C128S;H134R) induced muscle activation for minutes or even for hours (‘Quint’: ChR2(C128S;L132C;H134R;D156A;T159C)), thus featuring longer open state lifetime than previously described variants. Furthermore, stability after ATR removal was increased compared to the step-function opsin ChR2(C128S). The double mutants C128S;H134R and H134R;D156C enabled increased effects during repetitive stimulation. We also tested new hyperpolarizers (ACR1, ACR2, ACR1(C102A), ZipACR). Particularly ACR1 and ACR2 showed strong effects in behavioral assays and very large currents with fast kinetics. In sum, we introduce highly light-sensitive optogenetic tools, bypassing previous shortcomings, and thus constituting new tools that feature high effectiveness and fast kinetics, allowing better repetitive stimulation or investigating prolonged neuronal activity states in C. elegans and, possibly, other systems.
The increased susceptibility to infections of neonates is caused by an immaturity of the immune system as a result of both qualitative and quantitative differences between neonatal and adult immune cells. With respect to B cells, neonatal antibody responses are known to be decreased. Accountable for this is an altered composition of the neonatal B cell compartment towards more immature B cells. However, it remains unclear whether the functionality of individual neonatal B cell subsets is altered as well. In the current study we therefore compared phenotypical and functional characteristics of corresponding neonatal and adult B cell subpopulations. No phenotypic differences could be identified with the exception of higher IgM expression in neonatal B cells. Functional analysis revealed differences in proliferation, survival, and B cell receptor signaling. Most importantly, neonatal B cells showed severely impaired class-switch recombination (CSR) to IgG and IgA. This was associated with increased expression of miR-181b in neonatal B cells. Deficiency of miR-181b resulted in increased CSR. With this, our results highlight intrinsic differences that contribute to weaker B cell antibody responses in newborns.
Background: Leaf venation traits are important for many research fields such as systematics and evolutionary biology, plant physiology, climate change, and paleoecology. In spite of an increasing demand for vein trait data, studies are often still data-limited because the development of methods that allow rapid generation of large sets of vein data has lagged behind. Recently, non-destructive X-ray technology has proven useful as an alternative to traditional slow and destructive chemical-based methods. Non-destructive techniques more readily allow the use of herbarium specimens, which provide an invaluable but underexploited resource of vein data and related environmental information. The utility of 2D X-ray technology and microfocus X-ray computed tomography, however, has been compromised by insufficient image resolution. Here, we advanced X-ray technology by increasing image resolution and throughput without the application of contrast agents.
Results: For 2D contact microradiography, we developed a method which allowed us to achieve image resolutions of up to 7 µm, i.e. a 3.6-fold increase compared to the industrial standard (25 µm resolution). Vein tracing was further optimized with our image processing standards that were specifically adjusted for different types of leaf structure and the needs of higher imaging throughput. Based on a test dataset, in 91% of the samples the 7 µm approach led to a significant improvement in estimations of minor vein density compared to the industrial standard. Using microfocus X-ray computed tomography, very high-resolution images were obtained from a virtual 3D–2D transformation process, which was superior to that of 3D images.
Conclusions: Our 2D X-ray method with a significantly improved resolution advances rapid non-destructive bulk scanning at a quality that in many cases is sufficient to determine key venation traits. Together with our high-resolution microfocus X-ray computed tomography method, both non-destructive approaches will help in vein trait data mining from museum collections, which provide an underexploited resource of historical and recent data on environmental and evolutionary change. In spite of the significant increase in effective image resolution, a combination of high-throughput and full visibility of the vein network (including the smallest veins and their connectivity) remains challenging, however.
The likelihood of pathological complete remission (pCR) of breast cancer following neoadjuvant chemotherapy (NACT) is increasing; most of all in the triple negative and HER2 positive tumour subgroups. The question thus arises whether or not breast surgery is necessary when there is complete remission after NACT, and whether it provides any improvement of the oncological treatment result when tumour is no longer detectable. Avoiding surgery and possibly even radiotherapy would only be conceivable on the basis of a reliable diagnosis of pCR without operating. Current imaging does not achieve the necessary sensitivity and specificity to assure the diagnosis of pathological complete remission. Further studies are therefore required to determine which methods are best able to evaluate tumour response to NACT. Studies on image-guided, minimally invasive biopsies after NACT have delivered first promising results towards diagnosing pCR before surgery and could provide the basis for further studies on the possibility of avoiding surgery in this specific patient collective.
I present a new business cycle model in which decision making follows a simple mental process motivated by neuroeconomics. Decision makers first compute the value of two different options and then choose the option that offers the highest value, but with errors. The resulting model is highly tractable and intuitive. A demand function in level replaces the traditional Euler equation. As a result, even liquid consumers can have a large marginal propensity to consume. The interest rate affects consumption through the cost of borrowing and not through intertemporal substitution. I discuss the implications for stimulus policies.
This paper analyses whether the post-crisis regulatory reforms developed by global-standard-setting bodies have created appropriate incentives for different types of market participants to centrally clear Over-The-Counter (OTC) derivative contracts. Beyond documenting the observed facts, we analyze four main drivers for the decision to clear: 1) the liquidity and riskiness of the reference entity; 2) the credit risk of the counterparty; 3) the clearing member’s portfolio net exposure with the Central Counterparty Clearing House (CCP) and 4) post trade transparency. We use confidential European trade repository data on single-name Sovereign Credit Derivative Swap (CDS) transactions, and show that for all the transactions reported in 2016 on Italian, German and French Sovereign CDS 48% were centrally cleared, 42% were not cleared despite being eligible for central clearing, while 9% of the contracts were not clearable because they did not satisfy certain CCP clearing criteria. However, there is a large difference between CCP clearing members that clear about 53% of their transactions and non-clearing members, even those that are subject to counterparty risk capital requirements, that almost never clear their trades. Moreover, we find that diverse factors explain clearing members’ decision to clear different CDS contracts: for Italian CDS, counterparty credit risk exposures matter most for the decision to clear, while for French and German CDS, margin costs are the most important factor for the decision. Clearing members use clearing to reduce their exposures to the CCP and largely clear contracts when at least one of the traders has a high counterparty credit risk.
The longevity of the population in the Okinawa Islands of Japan has been ascribed to genetic factors and the traditional Okinawa cuisine, which is low in calories and high in plant content. This diet includes shell ginger (Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm) of the ginger family (Zingiberaceae). Due to its local popularity, Alpinia zerumbet has become the subject of a good deal of study at the University of the Ryukyus in Okinawa. Personal local experience and review of the literature now suggest that culinary shell ginger may contribute to longevity among the population in Okinawa. This is supported by its abundant phytochemical content, with antioxidant and anti-obesity properties. The major bioactive phytochemicals are dihydro-5,6-dehydrokawain (DDK; 80–410 mg g−1 fresh weight), 5,6-dehydrokawain (DK; ≤100 mg g−1), and essential oils, phenols, phenolic acids, and fatty acids (≤150 mg g−1 each). Further, Alpinia zerumbet extends the lifespan in animals by 22.6%. In conclusion, culinary shell ginger may significantly contribute to human longevity in Okinawa.
The blue light-dependent interaction between the proteins iLID and Nano allows recruiting and patterning proteins on GUV membranes, which thereby capture key features of patterns observed in nature. This photoswitchable protein interaction provides non-invasive, reversible and dynamic control over protein patterns of different sizes with high specificity and spatiotemporal resolution.
Compared to their protein-coding counterparts, almost nothing is known about the role of long noncoding RNAs (lncRNAs) in cardiac fibrosis. In the current report, Liang and Pan et al. characterized the pro-fibrotic lncRNA PFL in respect to cardiac fibrosis in mice. PFL was upregulated in the hearts of mice after myocardial infarction and in fibrotic cardiac fibroblasts. Moreover, PFL competitively sponged the cardio-protective miRNA let-7d in cardiac fibroblasts. Knockdown of platelet activating factor receptor (PTAFR) was shown to affect the pro-fibrotic collagen production mediated by PFL. PTAFR overexpression also led to collagen production and RNA abundance of PTAFR was also regulated by miRNA let-7d. Therefore, the PFL/PTAFR/let-7d-dependent gene regulatory mechanism proposed by the authors manifests the hypothesis of competing endogenous RNAs to cardiac fibrosis.
Digitalization expands the possibility for corporations to reduce taxes, mainly, but not exclusively, by allowing improved planning where profits can be shifted. Against this background, the European Commission and several countries emphatically demand and design new tax instruments. However, a selective turning away from internationally accepted principles of international taxation will bring up more questions than solutions. While there are good reasons to think about a fundamental regime switch in international corporate taxation, there are also good arguments for not turning to ad hoc measures that selectively target the relatively small market of Google and Facebook and raise only negligible tax revenues.
Monetary policy and prudential supervision – from functional separation to a holistic approach?
(2018)
When prudential supervision was put in the hands of the European Central Bank (ECB), it was the political understanding that the ECB should follow a policy of meticulous separation between monetary policy and financial supervision. However, the financial crisis showed that monetary policy and prudential supervision deeply affect each other and that an overly strict separation might generate systemic risk. As a consequence, the prevalent model of “functional separation” – central banking and financial supervision in separate entities – has been questioned and calls for a more holistic approach increased.
This policy letter states that from a legal perspective, such a holistic approach would be in conformity with the current legal framework of the Economic and Monetary Union. Although the realization of a holistic approach might intensify the doubts of democratic legitimation under the framework of the ESCB, the independence of the ECB should not be given up. As viable alternatives to protect monetary policy against the time inconsistency problem that would render central bank independence moot do not seem to be available and given the great importance of the independence of the European institutions for the European integration, the democratic control over the ECB should be strengthened instead of stripping the ECB of its independence.
Automated deduction in higher-order program calculi, where properties of transformation rules are demanded, or confluence or other equational properties are requested, can often be done by syntactically computing overlaps (critical pairs) of reduction rules and transformation rules. Since higher-order calculi have alpha-equivalence as fundamental equivalence, the reasoning procedure must deal with it. We define ASD1-unification problems, which are higher-order equational unification problems employing variables for atoms, expressions and contexts, with additional distinct-variable constraints, and which have to be solved w.r.t. alpha-equivalence. Our proposal is to extend nominal unification to solve these unification problems. We succeeded in constructing the nominal unification algorithm NomUnifyASC. We show that NomUnifyASC is sound and complete for these problem class, and outputs a set of unifiers with constraints in nondeterministic polynomial time if the final constraints are satisfiable. We also show that solvability of the output constraints can be decided in NEXPTIME, and for a fixed number of context-variables in NP time. For terms without context-variables and atom-variables, NomUnifyASC runs in polynomial time, is unitary, and extends the classical problem by permitting distinct-variable constraints.
1998 ACM Subject Classification F.4.1 Mathematical Logic
Strong imprints of Indian culture in various forms or modes of expressions are significantly found in Java. Sanskrit-Old Javanese texts, amongst those texts and traditions, were produced in the island in the periods between 9th to 15th cen. A.D. It covers various genres and subjects enriching indigenous culture in the archipelago. Tutur or tattva texts were one genre of them recorded the dynamic of Javanese intellectuals or poet-sages in pursuing the truth; they reveal metaphysical or theological aspects of Brahmanism, Saivism, Buddhism, Tantrism, Samkhya, Yoga, etc. This paper attempts to study ideas behind the Hindi transliteration and translation of those texts. This is a library reserach, the data were collected from Hindi translation of those texts. This attempt is of high scientific and cultural values as Indian scholars paid attention to Indian culture spreading in foreign lands. With this attempt Indian intellectuals/scholars/students got acquainted with their own culture flourished outside India in different forms, since the works were written and produced in Devanagari script and Hindi language. It creates nuances of being Indian. It can widen their understanding on philosophical point of view, religious elements, and culture of Java, that unity in diversity does not only exist in native land but also abroad.
This study investigated associations between parenting stress in parents and self-reported stress in children with children's diurnal cortisol secretion and whether these associations are moderated by known stress-regulating capacities, namely child cognitive control. Salivary cortisol concentrations were assessed from awakening to evening on two weekend days from 53 6-to-7-year-old children. Children completed a cognitive control task and a self-report stress questionnaire with an experimenter, while parents completed a parenting stress inventory. Hierarchical, linear mixed effects models revealed that higher parenting stress was associated with overall reduced cortisol secretion in children, and this effect was moderated by cognitive control. Specifically, parenting stress was associated with reduced diurnal cortisol levels in children with lower cognitive control ability and not in children with higher cognitive control ability. There were no effects of self-reported stress in children on their cortisol secretion, presumably because 6-to-7-year-old children cannot yet self-report on stress experiences. Our results suggest that higher cognitive control skills may buffer the effects of parenting stress in parents on their children’s stress regulation in middle childhood. This could indicate that training cognitive control skills in early life could be a target to prevent stress-related disorders.
Background: We evaluated the sensitivity of the D-statistic, a parsimony-like method widely used to detect gene flow between closely related species. This method has been applied to a variety of taxa with a wide range of divergence times. However, its parameter space and thus its applicability to a wide taxonomic range has not been systematically studied. Divergence time, population size, time of gene flow, distance of outgroup and number of loci were examined in a sensitivity analysis.
Result: The sensitivity study shows that the primary determinant of the D-statistic is the relative population size, i.e. the population size scaled by the number of generations since divergence. This is consistent with the fact that the main confounding factor in gene flow detection is incomplete lineage sorting by diluting the signal. The sensitivity of the D-statistic is also affected by the direction of gene flow, size and number of loci. In addition, we examined the ability of the f-statistics, fˆGf^G and fˆhomf^hom, to estimate the fraction of a genome affected by gene flow; while these statistics are difficult to implement to practical questions in biology due to lack of knowledge of when the gene flow happened, they can be used to compare datasets with identical or similar demographic background.
Conclusions: The D-statistic, as a method to detect gene flow, is robust against a wide range of genetic distances (divergence times) but it is sensitive to population size. The D-statistic should only be applied with critical reservation to taxa where population sizes are large relative to branch lengths in generations.
The influenza vaccination is recommended for all German pregnant women and health care personnel (HCP). We are the first to publish vaccination rates of mothers of hospitalized newborns and HCP in neonatal units. Between September 2016 and March 2017, data were collected in our level-III neonatology department in this descriptive multidisciplinary study, using an anonymous questionnaire. As a result, 513 persons were asked to participate, including 330 parents and 183 HCP. We received an 80.3% (412/513) response rate, 87.3% (288/330), and 67.8% (124/183) from parents and HCP, respectively. Ten percent (16/160) of mothers and 4.7% (6/127) of fathers had been vaccinated in 2016–2017 and 54.4% (87/160) mothers and 52.2% (66/127) fathers ever in their lifetime. In 2016–2017, 51.2% (21/41) of physicians had been vaccinated, 25.5% (14/55) of nurses, and 50.0% (14/28) of other staff members. When comparing those who had more than five influenza vaccinations in their life time, physicians were at 43.9% (18/41) versus nurses at 10.9% (6/55) (p < 0.01), and other HCP at 7.4% (2/27) (p < 0.01). The influenza vaccine uptake rate of 10% in mothers of hospitalized neonates is disappointingly low, resulting in 90% of hospitalized neonates being potentially vulnerable to influenza infection at a time where the risk for influenza-related complication can be severe.
Background: Despite the numerous associations of vitamin D with health and disease, vitamin D deficiency is still common from a global perspective. While basic research, clinical and preventive activities grow constantly in vitamin D research, there is no in-depth analysis of the related global scientific productivity available so far.
Methods: Density equalizing mapping procedures (DEMP) were combined with socioeconomic benchmarks using the NewQIS platform.
Results: A total of 25,992 vitamin D-related research articles were identified between 1900 to 2014 with a significant increase (r2 = .6541) from 1900 to 2014. Authors located in Northern America – especially in the USA – distributed the majority of global vitamin D research, followed by their Western European counterparts. DEMP-analysis illustrates that Africa and South America exhibit only minor scientific productivity. Among high-income group countries, Scandinavian nations such as Denmark or Finland (2147.9 and 1607.7 vitamin D articles per GDP in 1000 billion USD) were highly active with regard to socioeconomic figures.
Conclusion: Networks dedicated to vitamin D research are present around the world. Overall, the Northern American and Western European nations occupy prominent positions. However, South American, African and Asian countries apart from Japan only play a minor role in the global research production related to vitamin D. Since vitamin D deficiency is currently increasing in the Americas, Europe and parts of the Middle East, research in these regions may need to be encouraged.
Background: In 2007, the European Association of Palliative Care (EAPC) provided a comprehensive set of recommendations and standards for the provision of adequate pediatric palliative care. A number of studies have shown deficits in pediatric palliative care compared to EAPC standards. In Germany, pediatric palliative care patients can be referred to specialized outpatient palliative care (SOPC) services, which are known to enhance quality of life, e.g. by avoiding hospitalization. However, current regulations for the provision of SOPC in Germany do not account for the different circumstances and needs of children and their families compared to adult palliative care patients. The "Evaluation of specialized outpatient palliative care (SOPC) in the German state of Hesse (ELSAH)" study aims to perform a needs assessment for pediatric patients (children, adolescents and young adults) receiving SOPC. This paper presents the study protocol for this assessment (work package II).
Methods/Design: The study uses a sequential mixed-methods study design with a focus on qualitative research. Data collection from professional and family caregivers and, as far as possible, pediatric patients, will involve both a written questionnaire based on European recommendations for pediatric palliative care, and semi-structured interviews. Additionally, professional caregivers will take part in focus group discussions and participatory observations. Interviews and focus groups will be tape- or video-recorded, transcribed verbatim and analyzed in accordance with the principles of grounded theory (interviews) and content analysis (focus groups). A structured field note template will be used to record notes taken during the participatory observations. Statistical Package for Social Sciences (SPSS, version 22 or higher) will be used for descriptive statistical analyses. The qualitative data analyses will be software-assisted by MAXQDA (version 12 or higher).
Discussion: This study will provide important information on what matters most to family caregivers and pediatric patients receiving SOPC. The results will add valuable knowledge to the criteria that distinguish SOPC for pediatric from SOPC for adult patients, and will provide an indication of how the German SOPC rule of procedure can be optimized to satisfy the special needs of pediatric patients.
Trial registration: Internet Portal of the German Clinical Trials Register (www.germanctr.de, DRKS-ID: DRKS00012431).
Background: Although polypharmacy can cause adverse health outcomes, patients often know little about their medication. A regularly conducted medication review (MR) can help provide an overview of a patient’s medication, and benefit patients by enhancing their knowledge of their drugs. As little is known about patient attitudes towards MRs in primary care, the objective of this study was to gain insight into patient-perceived barriers and facilitators to the implementation of an MR.
Methods: We conducted a qualitative study with a convenience sample of 31 patients (age ≥ 60 years, ≥3 chronic diseases, taking ≥5 drugs/d); in Hesse, Germany, in February 2016. We conducted two focus groups and, in order to ensure the participation of elderly patients with reduced mobility, 16 telephone interviews. Both relied on a semi-structured interview guide dealing with the following subjects: patients’ experience of polypharmacy, general design of MRs, potential barriers and facilitators to implementation etc. Interviews were audio-recorded, transcribed verbatim, and analysed by two researchers using thematic analysis.
Results: Patients’ average age was 74 years (range 62–88 years). We identified barriers and facilitators for four main topics regarding the implementation of MRs in primary care: patient participation, GP-led MRs, pharmacist-led MRs, and the involvement of healthcare assistants in MRs. Barriers to patient participation concerned patient autonomy, while facilitators involved patient awareness of medication-related problems. Barriers to GP-led MRs concerned GP’s lack of resources while facilitators related to the trusting relationship between patient and GP. Pharmacist-led MRs might be hindered by a lack of patients’ confidence in pharmacists’ expertise, but facilitated by pharmacies’ digital records of the patients’ medications. Regarding the involvement of healthcare assistants in MRs, a potential barrier was patients’ uncertainty regarding the extent of their training. Patients could, however, imagine GPs delegating some aspects of MRs to them.
Conclusions: Our study suggests that patients regard MRs as beneficial and expect indications for their medicines to be checked, and possible interactions to be identified. To foster the implementation of MRs in primary care, it is important to consider barriers and facilitators to the four identified topics.
Background: Methotrexate (MTX) remains the anchor drug in rheumatoid arthritis (RA) treatment, but is poorly tolerated or contraindicated in some patients. There is a wealth of data supporting the use of abatacept in combination with MTX, but data on alternative conventional synthetic disease-modifying antirheumatic drug (csDMARD) combinations with abatacept are scarce.
Methods: In this post-hoc exploratory analysis, efficacy and safety data were extracted from abatacept RA studies in which combination with csDMARDs other than MTX was permitted: three interventional trials (ATTAIN, ASSURE, and ARRIVE) and one real-world study (ACTION). Patients with moderate-to-severe RA received abatacept in combination with MTX, hydroxychloroquine, sulfasalazine, azathioprine, or leflunomide for 6 months to 2 years according to the study design. Change from baseline in physical function (Health Assessment Questionnaire—Disability Index (HAQ-DI); all studies) and 28-joint Disease Activity Score (C-reactive protein) (DAS28 (CRP); ATTAIN, ARRIVE, and ACTION), American College of Rheumatology response rates (ATTAIN), and safety were assessed for individual and pooled csDMARD combinations for each trial. A meta-analysis was also performed on pooled data for HAQ-DI and DAS28 (CRP) across interventional trials.
Results: Across all four studies, 731 patients received abatacept plus one non-MTX csDMARD (hydroxychloroquine n = 152; sulfasalazine n = 123; azathioprine n = 59; and leflunomide n = 397) and 2382 patients received abatacept plus MTX. Mean changes from baseline in HAQ-DI scores for abatacept plus MTX (all csDMARDs pooled) vs abatacept plus a non-MTX csDMARD were –0.54 vs –0.44 (ATTAIN), –0.43 vs –0.43 (ASSURE), and –0.39 vs –0.36 (ARRIVE). Mean changes from baseline in DAS28 (CRP) and ACR response rates were also similar with abatacept plus MTX or non-MTX csDMARDs. Data for individual non-MTX csDMARDs (pooled across studies) and real-world data were consistent with these findings. Rates of treatment-related adverse events and serious adverse events, respectively, for abatacept plus one non-MTX csDMARD vs abatacept plus MTX were 35.7% vs 41.7% and 2.4% vs 2.3% (ATTAIN), 58.0% vs 55.9% and 4.2% vs 1.7% (ASSURE), and 38.1% vs 44.3% and 0.6% vs 2.9% (ARRIVE).
Conclusions: Abatacept in combination with non-MTX csDMARDs is clinically effective and well tolerated in patients with moderate-to-severe RA, providing similar benefits to those seen with abatacept plus MTX.
Background: The present study aims to elucidate the state of gender equality in high-quality research by analyzing the representation of female authorships in the last decade (from 2008 to 2016).
Methods: Based on the Gendermetrics platform, 293,557 research articles from 54 journals listed in the Nature Index were considered covering the categories Life Science, Multidisciplinary, Earth & Environmental and Chemistry. The core method was the combined analysis of the proportion of female authorships and the female-to-male odds ratio for first, co- and last authorships. The distribution of prestigious authorships was measured by the Prestige Index.
Results: 29.8% of all authorships and 33.1% of the first, 31.8% of the co- and 18.1% of the last authorships were held by women. The corresponding female-to-male odds ratio is 1.19 (CI: 1.18–1.20) for first, 1.35 (CI: 1.34–1.36) for co- and 0.47 (CI: 0.46–0.48) for last authorships. Women are underrepresented at prestigious authorships compared to men (Prestige Index = -0.42). The underrepresentation accentuates in highly competitive articles attracting the highest citation rates, namely, articles with many authors and articles that were published in highest-impact journals. More specifically, a large negative correlation between the 5-Year-Impact-Factor of a journal and the female representation at prestigious authorships was revealed (r(52) = -.63, P < .001). Women publish fewer articles compared to men (39.0% female authors are responsible for 29.8% of all authorships) and are underrepresented at productivity levels of more than 2 articles per author. Articles with female key authors are less frequently cited than articles with male key authors. The gender-specific differences in citation rates increase the more authors contribute to an article. Distinct differences at the journal, journal category, continent and country level were revealed. The prognosis for the next decades forecast a very slow harmonization of authorships odds between the two genders.
Even though extensively investigated, the nature of working memory (WM) deficits in patients with schizophrenia (PSZ) is not yet fully understood. In particular, the contribution of different WM sub-processes to the severe WM deficit observed in PSZ is a matter of debate. So far, most research has focused on impaired WM maintenance. By analyzing different types of errors in a spatial delayed response task (DRT), we have recently demonstrated that incorrect yet confident responses (which we labeled as false memory errors) rather than incorrect/not-confident responses reflect failures of WM encoding, which was also impaired in PSZ. In the present study, we provide further evidence for a functional dissociation between confident and not-confident errors by manipulating the demands on WM maintenance, i.e., the length over which information has to be maintained in WM. Furthermore, we investigate whether these functionally distinguishable WM processes are impaired in PSZ. Twenty-four PSZ and 24 demographically matched healthy controls (HC) performed a spatial DRT in which the length of the delay period was varied between 1, 2, 4, and 6 s. In each trial, participants also rated their level of response confidence. Across both groups, longer delays led to increased rates of incorrect/not-confident responses, while incorrect/confident responses were not affected by delay length. This functional dissociation provides additional support for our proposal that false memory errors (i.e., confident errors) reflect problems at the level of WM encoding, while not-confident errors reflect failures of WM maintenance. Schizophrenic patients showed increased numbers of both confident and not-confident errors, suggesting that both sub-processes of WM—encoding and maintenance—are impaired in schizophrenia. Combined with the delay length-dependent functional dissociation, we propose that these impairments in schizophrenic patients are functionally distinguishable.