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Hepatocyte nuclear factor 4α (HNF4α) is a ligand-sensing transcription factor and presents as a potential drug target in metabolic diseases and cancer. In humans, mutations in the HNF4α gene cause maturity-onset diabetes of the young (MODY), and the elevated activity of this protein has been associated with gastrointestinal cancers. Despite the high therapeutic potential, available ligands and structure–activity relationship knowledge for this nuclear receptor are scarce. Here, we disclose a chemically diverse collection of orthogonally validated fragment-like activators as well as inverse agonists, which modulate HNF4α activity in a low micromolar range. These compounds demonstrate the druggability of HNF4α and thus provide a starting point for medicinal chemistry as well as an early tool for chemogenomics.
leporello #7
(2021)
Sprachpotenziale stärken : das Projekt Herkunftssprachen im Sprachenzentrum der Goethe-Universität
(2020)
Am 22. November 2019 fand der Workshop „Mit Gender-Wissen in die Praxis“ im Seminarpavillon der Goethe-Universität statt. Die Veranstaltung wurde von Dr. Minna Ruokonen-Engler und Dr. Ewa Palenga-Möllenbeck in Kooperation mit dem Cornelia-Goethe-Centrum veranstaltet und aus dem Ruth-Moufang-Fonds vom Zentralen Gleichstellungsbüro und dem Fachbereich Gesellschaftswissenschaften finanziert. Der Workshop zielte darauf ab, Studierenden der Gender Studies sowie Interessierten Einblicke in verschiedene Berufsfelder der Gender Studies zu geben und Studierende mit den Praktiker*innen zu vernetzen...