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In vivo functional diversity of midbrain dopamine neurons within identified axonal projections
(2019)
Functional diversity of midbrain dopamine (DA) neurons ranges across multiple scales, from differences in intrinsic properties and connectivity to selective task engagement in behaving animals. Distinct in vitro biophysical features of DA neurons have been associated with different axonal projection targets. However, it is unknown how this translates to different firing patterns of projection-defined DA subpopulations in the intact brain. We combined retrograde tracing with single-unit recording and labelling in mouse brain to create an in vivo functional topography of the midbrain DA system. We identified differences in burst firing among DA neurons projecting to dorsolateral striatum. Bursting also differentiated DA neurons in the medial substantia nigra (SN) projecting either to dorsal or ventral striatum. We found differences in mean firing rates and pause durations among ventral tegmental area (VTA) DA neurons projecting to lateral or medial shell of nucleus accumbens. Our data establishes a high-resolution functional in vivo landscape of midbrain DA neurons.
Kaum ein Name ist so eng mit dem "Projekt HSAKA" verbunden wie der von Wolf Aßmus: Seit der ersten Hessischen Schülerakademie für die Oberstufe im Jahre 2004 ist er als Leiter des Physik-Kurses dabei; die Gründung der Mittelstufenakademie 2011 wurde von ihm tatkräftig unterstützt und gefördert; einen Sitz im Kuratorium hat er ebenso übernommen wie das Amt des Ersten Vorsitzenden des Trägervereins von Burg Fürsteneck – der inzwischen pensionierte Professor für Festkörperphysik verkörpert geradezu die Idee vom "Un-Ruhestand". Wer mag es ihm da verübeln, wenn Wolf beschließt, im nächsten Sommer mal mehr Zeit mit seinen Enkeln zu verbringen, statt auf die Burg zu fahren? Weil es daher 2020 zum ersten Mal eine Oberstufenakademie ohne Wolf und ohne Physik-Kurs geben wird (stattdessen Philosophie und Informatik), haben wir auf der vergangenen Akademie die Gelegenheit genutzt, Wolf für 15 Jahre Schülerakademie zu danken. Genauer gesagt: für 15 Jahre, 16 Fachkurse in Physik (15 auf der Oberstufenakademie und einer bei der Mittelstufe), 15 kursübergreifende Naturkunde-Angebote, für die Betreuung Dutzender Studierender und weit über 200 Schüler*innen, für unzählige gemeinsame Aha-Erlebnisse und humorvolle Geschichten, für unermüdliches Engagement und geduldigen Beistand – und nicht zuletzt für viele, viele Liter Speiseeis. Unsere Dankbarkeit wollen wir hier mit allen Leser*innen dieser Dokumentation teilen.
Wir konnten unseren eigenen Weg gehen, jeder von uns hatte am Ende ein anderes Ergebnis und es war keines falsch. Das macht für mich die Qualität beim Lernen aus, dass mir genug Platz für meine Gedanken gegeben wird und ich ernst genommen werde. […] Dieses Gefühl ist bis heute nicht verloren gegangen und der Gedanke, wie es sein könnte, hilft mir, aus mir raus zukommen und andere zu motivieren, das ebenfalls zu tun, um auch um mich herum anregende Gespräche zu führen, die an die während der Akademie geführten heranreichen. (Feedback einer Teilnehmerin der HSAKA-M 2018)
Bildung durch Wissenschaft im Sinne des Forschenden Lernens ist ein zentrales Thema schulischer Bildung und findet beispielsweise im Konzept Kultur.Forscher! eine didaktische, schulische Umsetzung und wird vom Wissenschaftsrat als Leitgedanke ebenfalls für Universitäten mit dem Ziel empfohlen, Studium und Lehre deutlicher an der Forschung auszurichten.
Uniqueness and Lipschitz stability in electrical impedance tomography with finitely many electrodes
(2019)
For the linearized reconstruction problem in electrical impedance tomography with the complete electrode model, Lechleiter and Rieder (2008 Inverse Problems 24 065009) have shown that a piecewise polynomial conductivity on a fixed partition is uniquely determined if enough electrodes are being used. We extend their result to the full non-linear case and show that measurements on a sufficiently high number of electrodes uniquely determine a conductivity in any finite-dimensional subset of piecewise-analytic functions. We also prove Lipschitz stability, and derive analogue results for the continuum model, where finitely many measurements determine a finite-dimensional Galerkin projection of the Neumann-to-Dirichlet operator on a boundary part.
We contribute to the foundations of tropical geometry with a view toward formulating tropical moduli problems, and with the moduli space of curves as our main example. We propose a moduli functor for the moduli space of curves and show that it is representable by a geometric stack over the category of rational polyhedral cones. In this framework, the natural forgetful morphisms between moduli spaces of curves with marked points function as universal curves.
Our approach to tropical geometry permits tropical moduli problems—moduli of curves or otherwise—to be extended to logarithmic schemes. We use this to construct a smooth tropicalization morphism from the moduli space of algebraic curves to the moduli space of tropical curves, and we show that this morphism commutes with all of the tautological morphisms.
We derive a simple criterion that ensures uniqueness, Lipschitz stability and global convergence of Newton’s method for the finite dimensional zero-finding problem of a continuously differentiable, pointwise convex and monotonic function. Our criterion merely requires to evaluate the directional derivative of the forward function at finitely many evaluation points and for finitely many directions. We then demonstrate that this result can be used to prove uniqueness, stability and global convergence for an inverse coefficient problem with finitely many measurements. We consider the problem of determining an unknown inverse Robin transmission coefficient in an elliptic PDE. Using a relation to monotonicity and localized potentials techniques, we show that a piecewise-constant coefficient on an a-priori known partition with a-priori known bounds is uniquely determined by finitely many boundary measurements and that it can be uniquely and stably reconstructed by a globally convergent Newton iteration. We derive a constructive method to identify these boundary measurements, calculate the stability constant and give a numerical example.
We show that the metrisability of an oriented projective surface is equivalent to the existence of pseudo-holomorphic curves. A projective structure p and a volume form σ on an oriented surface M equip the total space of a certain disk bundle Z→M with a pair (Jp,Jp,σ) of almost complex structures. A conformal structure on M corresponds to a section of Z→M and p is metrisable by the metric g if and only if [g]:M→Z is a pseudo-holomorphic curve with respect to Jp and Jp,dAg.
We study continuous dually epi-translation invariant valuations on certain cones of convex functions containing the space of finite-valued convex functions. Using the homogeneous decomposition of this space, we associate a certain distribution to any homogeneous valuation similar to the Goodey-Weil embedding for translation invariant valuations on convex bodies. The support of these distributions induces a corresponding notion of support for the underlying valuations, which imposes certain restrictions on these functionals, and we study the relation between the support of a valuation and its domain. This gives a partial answer to the question which dually epi-translation invariant valuations on finite-valued convex functions can be extended to larger cones of convex functions.
We also study topological properties of spaces of valuations with support contained in a fixed compact set. As an application of these results, we introduce the class of smooth valuations on convex functions and show that the subspace of smooth dually epi-translation invariant valuations is dense in the space of continuous dually epi-translation invariant valuation on finite-valued convex functions. These smooth valuations are given by integrating certain smooth differential forms over the graph of the differential of a convex function. We use this construction to give a characterization of a dense subspace of all continuous valuations on finite-valued convex functions that are rotation invariant as well as dually epi-translation invariant.
Using results from Alesker's theory of smooth valuations on convex bodies, we also show that any smooth valuation can be written as a convergent sum of mixed Hessian valuations. In particular, mixed Hessian valuations span a dense subspace, which is a version of McMullen’s conjecture for valuations on convex functions.
We use recent results by Bainbridge–Chen–Gendron–Grushevsky–Möller on compactifications of strata of abelian differentials to give a comprehensive solution to the realizability problem for effective tropical canonical divisors in equicharacteristic zero. Given a pair (Γ,D) consisting of a stable tropical curve Γ and a divisor D in the canonical linear system on Γ, we give a purely combinatorial condition to decide whether there is a smooth curve X over a non-Archimedean field whose stable reduction has Γ as its dual tropical curve together with an effective canonical divisor KX that specializes to D.
The specific temporal evolution of bacterial and phage population sizes, in particular bacterial depletion and the emergence of a resistant bacterial population, can be seen as a kinetic fingerprint that depends on the manifold interactions of the specific phage–host pair during the course of infection. We have elaborated such a kinetic fingerprint for a human urinary tract Klebsiella pneumoniae isolate and its phage vB_KpnP_Lessing by a modeling approach based on data from in vitro co-culture. We found a faster depletion of the initially sensitive bacterial population than expected from simple mass action kinetics. A possible explanation for the rapid decline of the bacterial population is a synergistic interaction of phages which can be a favorable feature for phage therapies. In addition to this interaction characteristic, analysis of the kinetic fingerprint of this bacteria and phage combination revealed several relevant aspects of their population dynamics: A reduction of the bacterial concentration can be achieved only at high multiplicity of infection whereas bacterial extinction is hardly accomplished. Furthermore the binding affinity of the phage to bacteria is identified as one of the most crucial parameters for the reduction of the bacterial population size. Thus, kinetic fingerprinting can be used to infer phage–host interactions and to explore emergent dynamics which facilitates a rational design of phage therapies.