Medizin
Refine
Year of publication
- 2017 (311) (remove)
Document Type
- Article (309)
- Doctoral Thesis (1)
- Preprint (1)
Language
- English (311) (remove)
Has Fulltext
- yes (311)
Is part of the Bibliography
- no (311)
Keywords
- glioblastoma (8)
- Inflammation (4)
- Neuroscience (4)
- multiple sclerosis (4)
- Apoptosis (3)
- Denosumab (3)
- Kinematic analysis (3)
- Mechanisms of disease (3)
- Mitochondria (3)
- Molecular biology (3)
- Musculoskeletal disorder (3)
- Parkinson’s disease (3)
- Stroke (3)
- bevacizumab (3)
- inflammation (3)
- p47phox (3)
- Apheresis (2)
- Biochemistry (2)
- Biomarker (2)
- Biomarkers (2)
- Breast cancer (2)
- COPD (2)
- CXCR4 (2)
- Cancer models (2)
- Cell biology (2)
- Chemotherapy (2)
- Clinical trial (2)
- Cuela (2)
- Dentist (2)
- Depression (2)
- Drug therapy (2)
- Forensic entomology (2)
- Gender (2)
- General practice (2)
- Genetics (2)
- Head and neck cancer (2)
- Human behaviour (2)
- Leukemias (2)
- Liver transplantation (2)
- MCI (2)
- NADPH oxidase (2)
- NK cells (2)
- Neuroinflammation (2)
- NoxO1 (2)
- OSCE (2)
- Oncology (2)
- Osteoporosis (2)
- Prediction (2)
- Research article (2)
- Respiratory chain (2)
- Sarcoma (2)
- Sex differences (2)
- Surgeons (2)
- Tissue engineering (2)
- Trauma (2)
- anti-angiogenic therapy (2)
- antisocial behavior (2)
- apoptosis (2)
- autophagy (2)
- bibliometry (2)
- conduct disorder (2)
- data science (2)
- elderly (2)
- epidemiology (2)
- glioma (2)
- information theory (2)
- miRNAs (2)
- natural killer cells (2)
- perception (2)
- phagocytosis (2)
- registry (2)
- schizophrenia (2)
- stability (2)
- (surface) partial differential equations (1)
- 3D spatio-temporal resolved mathematical models (1)
- A-PRF+ (1)
- ADHD (1)
- ALL (1)
- AMP-activated kinase (1)
- AMPK (1)
- ASA404 (1)
- AZD7762 (1)
- Academic health centres (1)
- Academic medicine (1)
- Academics (1)
- Accessibility (1)
- Activity control (1)
- Acute heart failure (1)
- Acute inflammation (1)
- Acute lymphoblastic leukemia (1)
- Acute myeloid leukaemia (1)
- Adherence (1)
- Adipose tissue (1)
- Adipose tissue-derived mesenchymal stem cells (1)
- Adult (1)
- Adult neurogenesis (1)
- Africa (1)
- Alcoholic liver disease (1)
- Allergy (1)
- Alternative oxidase (1)
- Alzheimer’s dementia (1)
- Amygdala (1)
- Amyloid-beta 42 (1)
- Andersen-Tawil syndrome (1)
- Angiogenesis (1)
- Angiogenèse (1)
- Anticoagulation (1)
- Antidepressant (1)
- Antiviral response (1)
- Area deprivation (1)
- Arteriogenesis (1)
- Artesunate (1)
- Aspergillus (1)
- Aspergillus fumigatus (1)
- Assessment (1)
- Asthma and allergic disorders (1)
- Atherosclerosis (1)
- Atrial fibrillation (1)
- Attack (1)
- Attention (1)
- Attitude (1)
- Autism spectrum disorders (1)
- Autoimmune encephalomyelitis (1)
- Autophagy (1)
- Azacitidine (1)
- B cell receptor (1)
- BCL6 (1)
- BDNF (1)
- BRAF (1)
- BRAF V600E (1)
- BRD4 (1)
- BRD4-NUT (1)
- BV6 (1)
- BadA, (1)
- Batten disease (1)
- Bias (1)
- Big Data (1)
- Biliary physiology (1)
- Bioinformatics (1)
- Biopsy (1)
- Bipolar disorder (1)
- Bladder cancer (1)
- Blood (1)
- Blow fly (1)
- Blowflies (1)
- Bone and joint mechanics (1)
- Bone marrow-derived mesenchymal stem cells (1)
- Bone metastasis (1)
- Bone tissue engineering (1)
- Breast neoplasms (1)
- Breast reconstruction (1)
- Bronchodilator agents (1)
- C57BL/6J mice (1)
- C57BL/6N mice (1)
- CA (1)
- CAT (1)
- CD16 (1)
- CD56 (1)
- CD8 (1)
- CDK4/CDK6 (1)
- CGD (1)
- CPE (1)
- CRISPR/Cas9 (1)
- CT (1)
- CT-guidance (1)
- CUELA (1)
- CUP (1)
- Calliphoridae (1)
- Callous-unemotional traits (1)
- Cancer chemotherapy (1)
- Cancer detection and diagnosis (1)
- Cancer epigenetics (1)
- Cancer genetics (1)
- Cancer of unknown primary (1)
- Cancer treatment (1)
- Candida (1)
- Cardiac surgery (1)
- Cardiogenic shock (1)
- Cardiopulmonary bypass (1)
- Cardiovascular magnetic resonance (1)
- Career promotion (1)
- Case management (1)
- Catheter ablation (1)
- Cell adhesion (1)
- Cell metabolism (1)
- Cell processing (1)
- Cell signalling (1)
- Cell-assisted lipotransfer (1)
- Cellular imaging (1)
- Cellular inflammatory response (1)
- Centrifugation (1)
- Cerebrovascular (1)
- Cervical (1)
- Checkpoint kinase (1)
- Chemoradiotherapy (1)
- Children (1)
- Chondrocyte (1)
- Chondrocyte signalling (1)
- Chromosomal deletion (1)
- Cinryze® (1)
- Cirrhosis (1)
- Citation (1)
- Classification (1)
- Cleft palate (1)
- Clinical genetics (1)
- Clinical study (1)
- Clinical trials (1)
- Clinical variation (1)
- Cln3 (1)
- Cognitive neuroscience (1)
- Cohort studies (1)
- Cold pain (1)
- Colonisation (1)
- Complexin 1 (1)
- Compliance (1)
- Conditional gene trap (1)
- Connective tissue (1)
- Consciousness (1)
- Conservative (1)
- Constrained posture (1)
- Contact precautions (1)
- Coronary heart disease (1)
- Critical care and emergency medicine (1)
- Crosscorrelation (1)
- Cryptococcus (1)
- CyberKnife (1)
- Cytokines (1)
- DILI (1)
- DMXAA (1)
- DSS /AOM (1)
- Data science (1)
- Death rates (1)
- Decision (1)
- Denervation (1)
- Density equalizing mapping (1)
- Dentistry (1)
- Developmental biology (1)
- Diabetes mellitus (1)
- Diagnostic markers (1)
- Differential expression (1)
- Differentiation (1)
- Digenic model (1)
- Diphosphonates (1)
- Direct current electrical stimulation (1)
- Disintegration (1)
- Dose optimization (1)
- Drug resistance/synergy (1)
- Drug screens (1)
- E-Learning (1)
- E-cadherin (1)
- E-cadhérine (1)
- ECLS (1)
- ECMO (1)
- EDTA-plasma (1)
- EEG-fMRI (1)
- EGF (1)
- ERSCongress (1)
- ESBL (1)
- Economic benchmarks (1)
- Education (1)
- Efficacy (1)
- Elderly (1)
- Embolization (1)
- Endoplasmic reticulum (1)
- Endosomes (1)
- Endothelial nitric oxide synthase (1)
- Endotoxins (1)
- Enteral nutrition (1)
- Epidemiology (1)
- Epilepsy (1)
- Equity (1)
- Europe (1)
- European Union (1)
- Evaluation in microsurgery (1)
- Evidence-based dentistry (1)
- Evidence-based medicine (1)
- Evolutionary biology (1)
- Exacerbations (1)
- Experimental autoimmune encephalomyelitis (1)
- Experimental models of disease (1)
- Extension study (1)
- Extracellular vesicles (1)
- Extracorporeal circulation (1)
- Extreme hypo-fractionation (1)
- FEV1 (1)
- FREEDOM (1)
- Falciparum (1)
- Family Physician (1)
- Fascia (1)
- Feasibility (1)
- Feline bartonellosis (1)
- Finite Volumes (1)
- Flexibility (1)
- Flow cytometry (1)
- Fluorescence imaging (1)
- Foam rolling (1)
- Frailty (1)
- Frankfurt microsurgery course (1)
- Functional characterization (1)
- Fusion Proteins, BCR-ABL (1)
- G-CSF (1)
- G9a/EHMT2/KMT1C (1)
- GRX1-roGFP2 (1)
- Gaba (1)
- Gadobutrol (1)
- Gemcitabine (1)
- Gender equality (1)
- Gene ontology (1)
- Gene set analysis (1)
- General practitioners (1)
- Genetic causes of cancer (1)
- Genetic testing (1)
- Genome-wide association studies (1)
- Germany (1)
- Global health (1)
- Glomerular diseases (1)
- Glucose metabolism (1)
- Growth factor (1)
- Growth factor signalling (1)
- Guidelines (1)
- HIF (1)
- HIV-1 (1)
- HLA class I loss (1)
- Health services research (1)
- Healthcare worker (1)
- Heart failure (1)
- Heat pain (1)
- Hematology (1)
- Hepatitis C virus (1)
- Hepatocytes (1)
- Hereditary angioedema (1)
- High-income countries (1)
- High-risk cardiac surgery (1)
- High-throughput screening (1)
- Hippocampal volume (1)
- Hippocampus (1)
- Hispanic people (1)
- Histology (1)
- Homeostasis (1)
- Hsp70 (1)
- Human experimental pain models (1)
- Human genetics (1)
- Hypertension (1)
- Hypoxia (1)
- I-PRF (1)
- IHC (1)
- IL -17 (1)
- IL -23 (1)
- IL 23p19 knockout mouse (1)
- IgG4-related disease (1)
- Immune receptor signaling (1)
- Indeterminate biliary stricture (1)
- Index (1)
- Indonesia (1)
- Infection control (1)
- Infectious disease (1)
- Insula (1)
- Insulin secretion (1)
- Integration (1)
- Integrins (1)
- KCNJ2 mutation (1)
- LCMV (1)
- LTB4 (1)
- Lateral recess stenosis (1)
- Le carcinome épidermoïde oral (1)
- Leadership (1)
- Learning algorithms (1)
- Learning and memory (1)
- Leber congenital amaurosis (1)
- Les macrophages associés aux tumeurs (1)
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive (1)
- Leukocytes (1)
- Leukotriene (1)
- Linear regression analysis (1)
- Lipid signalling (1)
- Liver diseases (1)
- Localized prostate cancer (1)
- Low back pain (1)
- Lpar2 (1)
- Lumbar spinal canal stenosis (1)
- Lumbar spine (1)
- Lung failure (1)
- Lymph node (1)
- Lysophosphatidic acids (1)
- MEG (1)
- MICA (1)
- MRSA (1)
- MTT assay (1)
- Machine-learning (1)
- Macroautophagy (1)
- Macrophages (1)
- Magnetic resonance imaging (1)
- Malaria (1)
- Manatee invariant (1)
- Mandible (1)
- Massive Online Open Course (1)
- Mathematical model (1)
- Mathematical models (1)
- Measurement equipment (1)
- Medical management (1)
- Medical student (1)
- Medication Appropriateness Index (1)
- Medicine (1)
- Mesenchymal stem cells (1)
- Mice (1)
- Micrognathia (1)
- Microsurgery (1)
- Midkine (1)
- Mild cognitive impairment (1)
- Mitochondrial disease (1)
- Mitochondrial dysfunction (1)
- Mitochondrial shuttles (1)
- Mitosis (1)
- Mobilization (1)
- Molecular medicine (1)
- Molecularly targeted therapy (1)
- Morphogenesis (1)
- Motivating factor (1)
- Mouse models (1)
- Multidrug resistance (1)
- Multidrug-resistant bacteria (1)
- Multinucleated giant cells (1)
- Multiomics (1)
- Multiple sclerosis (1)
- Muscle atrophy (1)
- Music chair concepts (1)
- Musician (1)
- Myelodysplastic syndrome (1)
- N-cadherin (1)
- N-cadhérine (1)
- NF-ĸB (1)
- NF-κB pathway (1)
- NHEJ (1)
- NK receptors (1)
- NKG2D (1)
- NK cells (1)
- National catalogue of competence-based learning objectives in dentistry (1)
- Neonatal outcome (1)
- Nepal (1)
- Network analysis (1)
- Neural networks (1)
- Neuroblastoma (1)
- Neurochemistry (1)
- Neurodegenerative diseases (1)
- Neuronal homeostasis (1)
- Neuronal networks (1)
- Neuronal nitric oxide synthase (1)
- Nociception (1)
- Non-REM sleep (1)
- Non-interventional study (1)
- Non-operative (1)
- Novel treatment target (1)
- Nox (1)
- Nox1 (1)
- NoxA1 (1)
- Nrf2 (1)
- Nucleolus (1)
- Nurses (1)
- Nutrition risk stratification (1)
- OSPE (1)
- Observational (1)
- Obstetric care (1)
- Oldest-old (1)
- Omics (1)
- Oral anticoagulation (1)
- Organ dysfunctions (1)
- Organ preservation (1)
- Orthodontist (1)
- Oswestry Disability Score (1)
- Outcome assessment (1)
- Outpatients (1)
- Ovarian cancer (1)
- Ovarian carcinoma (1)
- Oxygen-derived free radicals (1)
- PARK4 (1)
- PC12 neuronal differentiation (1)
- PCR (1)
- PEM-technology (1)
- PXA (1)
- Pain (1)
- Pancreatic islet (1)
- Pathologic changes (1)
- Pathology Section (1)
- Patient education (1)
- Patient knowledge (1)
- Pattern recognition receptors (1)
- Pediatric (1)
- Pediatric neuroimaging (1)
- Pediatric patients (1)
- Peripheral vascular disease (1)
- Persistence (1)
- Petri net (1)
- Pharmaco-nutrition (1)
- Phase I trials (1)
- Philadelphia Chromosome (1)
- Phospho-tau (1)
- Phosphorylation (1)
- Physicians (1)
- Physiology (1)
- Pierre Robin sequence (1)
- Plasmacytoid dendritic cell (1)
- Plasmodium (1)
- Platelet-rich fibrin (1)
- Platelets (1)
- Plerixafor (1)
- Post surgery pain (1)
- Post-translational modifications (1)
- Postoperative nutritional management (1)
- Postoperative radiochemotherapy (1)
- Posttraumatic stress disorder (1)
- Posttraumatische Belastungsstörung (1)
- Posture analysis (1)
- Potassium channel Kir2.1 (1)
- Practical skills (1)
- Practice-based research network (1)
- Pressure pain (1)
- Prevention (1)
- Primary Care Health Centre (1)
- Primary care (1)
- Primary sclerosing cholangitis (1)
- Prognosis (1)
- Prognostic (1)
- Prognostic markers (1)
- Protein Kinase Inhibitors (1)
- Psychiatric disorders (1)
- Psychology (1)
- Publication (1)
- Pulmonary disease, chronic obstructive (1)
- Pulmonary veins (1)
- Pulsed SILAC (1)
- Quality of life (1)
- Quantitative sensory testing (1)
- Quantitative trait (1)
- Quinine (1)
- R programming language (1)
- RBC-depletion (1)
- RD cells (1)
- REM sleep (1)
- RH30 cells (1)
- RNA Biology (1)
- RNA binding proteins (1)
- RNA isolation (1)
- RNA, long noncoding (1)
- ROS (1)
- RPE65 (1)
- RUCAM (1)
- Radiochemotherapy (1)
- Radiology and imaging (1)
- Radiotherapy (1)
- Random forest (1)
- Rapid eye movement sleep behavior disorder (1)
- Reactive oxygen species (1)
- Rectal cancer (1)
- Redox-sensitive GFP (1)
- Registries (1)
- Reperfusion (1)
- Replication study (1)
- Respiration (1)
- Respiratory Syncytial Virus (1)
- Restricted posture (1)
- Reticulon (1)
- Reverse transcription polymerase chain reaction (1)
- Robotic Radiosurgery (1)
- Roussel Uclaf Causality Assessment Method (1)
- Rtn3 (1)
- SCCHN (1)
- SDF-1 (1)
- SIADH (1)
- SIRT1 (1)
- SNP (1)
- STING (1)
- SUN1 (1)
- SUN2 (1)
- Safety (1)
- Salmonella choleraesuis (1)
- Scientifi c competence (1)
- Scientometry (1)
- Secondary injury cascades (1)
- Selection bias (1)
- Selective autophagy (1)
- Self-myofascial release (1)
- Severe malaria (1)
- Sexual Dysfunctions (1)
- Sexual child abuse (1)
- Sexual violence (1)
- Sexuelle Dysfunktionen (1)
- Sexuelle Gewalt (1)
- Sexueller Kindesmissbrauch (1)
- Signaling pathway (1)
- Simulation and modeling (1)
- Skills (1)
- Socio-economic analysis (1)
- Spanish National Health System (1)
- Species identification (1)
- Speciesidentification (1)
- Sphingolipids (1)
- Spinal cord (1)
- Spleen (1)
- Statistical data (1)
- Stem cell (1)
- Stem-cell therapies (1)
- Stereotactic body radiation therapy (1)
- Stimulation experiments (1)
- Stimulus-secretion coupling (1)
- Subgroup identification (1)
- Superoxide (1)
- Supplemental parenteral nutrition (1)
- Surgery (1)
- Surgical and invasive medical procedures (1)
- Sustainable Development (1)
- Switzerland (1)
- Symptoms (1)
- Synaptic dysfunction (1)
- Systematic reviews (1)
- Systemic inflammatory response (1)
- T cell (1)
- T-cell homing (1)
- T-cell receptor (1)
- TGF-β (1)
- TLR (1)
- Tailored medicine (1)
- Tas2r126 (1)
- Tas2r135 (1)
- Tas2r143 (1)
- Tau (1)
- Tau acetylation (1)
- Technicians (1)
- Thailand (1)
- Three-dimensional echocardiography (1)
- Time optimization (1)
- Time series (1)
- Tissue stiffness (1)
- Toll-like receptors (1)
- Torque (1)
- Training (1)
- Transesophageal echocardiography (1)
- Transient (1)
- Transient ischemic attack (1)
- Transition invariant (1)
- Transmission (1)
- Transplantation (1)
- Treatment (1)
- Twist (1)
- Type 2 Diabetes mellitus (1)
- UVA (1)
- Ubiquitin kinase PINK1 (1)
- Ubiquitination (1)
- Ultrasound (1)
- Underfeeding (1)
- Urothelial carcinoma (1)
- VIS (1)
- VRE (1)
- Vascular endothelial growth factor A (1)
- Vascular endothelial growth factor receptor 2 (1)
- Vascularization (1)
- Vector-borne infections (1)
- Vertigo (1)
- VirB (1)
- Voxel-based morphometry (1)
- Wait and see (1)
- Wakefulness (1)
- Wing morphometry (1)
- Women in medicine (1)
- Women in science (1)
- YK-4-279 (1)
- Zika fever (1)
- Zika virus (1)
- Zoonosis (1)
- ablation (1)
- academic (1)
- acceptable change limit (1)
- acetaminophen (1)
- adaptation plan (1)
- adiposity (1)
- adjustment disorder (1)
- adjuvant therapy (1)
- adjuvante Therapie (1)
- adolescence (1)
- adolescents’ health (1)
- adult neurogenesis (1)
- age-related macular degeneration (1)
- alcohol (1)
- allogeneic transplantation (1)
- anal cancer (1)
- anesthesiology (1)
- angiogenesis (1)
- anti-epileptic drug (1)
- antifungal host response (1)
- antioxidants (1)
- anxiety (1)
- architecture (1)
- arm (1)
- assay development (1)
- atrial fibrillation (1)
- attention (1)
- authorship (1)
- autoimmune diabetes (1)
- autoimmune encephalomyelitis (1)
- autophagic cell death (1)
- bile duct stenosis (1)
- bioenergetics (1)
- biologicals (1)
- biomarkers (1)
- bleomycin (1)
- blood (1)
- brain imaging (1)
- brain metastases (1)
- brain structure (1)
- brain tumor (1)
- brain-derived neurotrophic factor (1)
- breast cancer (1)
- bulimia nervosa (1)
- cGMP (1)
- calbindin (1)
- caloric restriction (1)
- cancer (1)
- cancer stem cells (1)
- cancer therapy (1)
- cannabinoid receptor type 1 (1)
- canonical (1)
- catheter ablation (1)
- cell death (1)
- cell fusion (1)
- cell signaling (1)
- cell therapy (1)
- ceramide (1)
- cerebral infarct (1)
- chemoattractant (1)
- chemoconvulsant (1)
- chemoembolization (1)
- chemoprevention (1)
- chemosensory cells (1)
- chemotherapy (1)
- children (1)
- chimeric antigen receptor (1)
- chronic colitis (1)
- chronic granulomatous disease (1)
- chronic kidney disease (CKD) (1)
- chronic thromboembolic pulmonary hypertension (1)
- chronotype (1)
- circadian (1)
- citation (1)
- climate change (1)
- clinical benefit (1)
- clinical competency (1)
- clinical tool (1)
- cluster of differentiation 4 (CD4) (1)
- cognition (1)
- cognitive control (1)
- cognitively stimulating leisure activities (1)
- cold induced pain (1)
- colon cancer (1)
- colonization (1)
- colorectal cancer (1)
- community violence exposure (1)
- complexity theory (1)
- computational modeling (1)
- computational virology (1)
- computed tomography (1)
- concentric (1)
- conditioning (1)
- consensus (1)
- crista junction (1)
- cristae (1)
- critical care unit (1)
- critical ill patients (1)
- criticality (1)
- cryoballoon (1)
- curcumin (1)
- cyclophilin A (1)
- cytokine-induced killer cells (1)
- dabrafenib (1)
- daily activity protocols (1)
- damage-associated molecular pattern (1)
- data quality check (1)
- deletion 5q (1)
- density equalizing mapping (1)
- dentate gyrus (1)
- depression (1)
- diabetes mellitus (1)
- diagnostic biomarkers (1)
- dialysis (1)
- diarrhoeal disease (1)
- diastolic function (1)
- differentiation (1)
- dihydroceramide (1)
- direct antiviral (1)
- direct-acting antivirals (1)
- directed forgetting (1)
- disease-modifying antirheumatic drugs (1)
- disease-modifying therapy (1)
- diurnal (1)
- doublecortin (1)
- drug induced liver injury (1)
- dual bronchodilators (1)
- early breast cancer (1)
- early infection (1)
- eating disorders (1)
- eccentric (1)
- echocardiography (1)
- ectopic pregnancy (1)
- electrophiles (1)
- emotional climate (1)
- endocannabinoids (1)
- endoscopic retrograde cholangiopancreatography (1)
- endoscopy (1)
- endothelial cells (1)
- endothelium (1)
- endotoxemia (1)
- enforced viral replication (1)
- eosinophilic cholangitis (1)
- epigenetics (1)
- epigenomics (1)
- epilepsy (1)
- epileptogenesis (1)
- ergometry (1)
- esophageal cancer (1)
- ex vivo stimulation (1)
- exosomes (1)
- expressed emotion (1)
- extracellular matrix (1)
- fatigue (1)
- female health (1)
- fibrin (1)
- fibroblasts (1)
- fibrogenesis (1)
- fibronectin (1)
- first-line chemotherapy (1)
- follow-up (1)
- frühes Mammakarzinom (1)
- function, sorting (1)
- galunisertib monohydrate (LY2157299) (1)
- gastric cancer (1)
- gender (1)
- gender equality (1)
- gender equality plan (1)
- gene regulation (1)
- gene therapy (1)
- gliomatosis cerebri growth pattern (1)
- guideline (1)
- hMOF/KAT8 (1)
- head and neck cancer (1)
- health economics (1)
- health information exchange (1)
- health literacy (1)
- healthcare professional (1)
- hematopoiesis (1)
- hematopoietic cells (1)
- hematopoietic stem cell transplantation (1)
- hepatic tumor (1)
- hepatitis B (1)
- hepatitis C (1)
- hepatitis C virus (1)
- heterogeneity of plasticity effects (1)
- high-throughput sequencing (1)
- hippocampal sclerosis (1)
- hippocampus (1)
- hotspot loci (1)
- household chaos (1)
- human experimental pain (1)
- human resources (1)
- hypertension, pulmonary (1)
- hyponatremia (1)
- hypothermia (1)
- ignition (1)
- imiquimod (1)
- immune escape (1)
- immune microenvironment (1)
- immune reconstitution (1)
- immune system (1)
- immune-modulating therapy (1)
- immunity (1)
- immunology (1)
- immunotherapy (1)
- in situ gene correction (1)
- indacaterol/glycopyrronium (1)
- inducible nitric oxide synthase (1)
- infiltration (1)
- inflammatory arthritis (1)
- infomax (1)
- inhibition (1)
- integration (1)
- inter-assay precision (1)
- interleukin-22 (1)
- internal time (1)
- intervention study (1)
- intoxication (1)
- intracerebral haemorrhage (1)
- invasive fungal infection (1)
- invasive growth (1)
- in vivo (1)
- ischemia (1)
- kidney transplantation (1)
- klinischer Nutzen (1)
- laminin (1)
- length of study (1)
- leptomeningeal disease (1)
- leukemia (1)
- leukocytosis (1)
- leukopenia (1)
- lipid signaling (1)
- lipocalin-2 (1)
- liver abscess (1)
- liver damage (1)
- liver metastases (1)
- locomotor rhythm (1)
- long noncoding RNAs (1)
- lung (1)
- lung cancer (1)
- lymph nodes (1)
- lysosomes (1)
- mRNA (1)
- mTOR (1)
- mTORC (1)
- macrophage (1)
- macrophage polarization (1)
- magnetic resonance imaging (1)
- massively parallel multigrid solvers (1)
- mathematical models of viral RNA cycle (1)
- melanoma (1)
- melatonin (1)
- membrane protein complex (1)
- membrane structure (1)
- memory performance (1)
- meningioma (1)
- mesenchymal stromal cells (1)
- metabolism (1)
- metabolomics (1)
- metastability (1)
- metastatic colorectal cancer (1)
- microRNAs (1)
- microdeletions (1)
- migration (1)
- mindfulness (1)
- mitochondria (1)
- monoclonal antibody (1)
- monocrotaline (1)
- monocytes (1)
- morbidity (1)
- motor neuron disease (1)
- mouse (1)
- mouse model (1)
- mucormycete (1)
- multifocal (1)
- mutated neoantigens (1)
- myelodysplastic syndrome (1)
- myeloperoxidase (1)
- natural killer cell (1)
- natural killer cell cultivation (1)
- natural killer cell cytotoxicity (1)
- natural killer cell expansion (1)
- natural killer cell therapy (1)
- negative symptoms (1)
- neoplasms (1)
- neovascularization, physiologic (1)
- nerve growth factor (NGF) (1)
- network (1)
- neural adaptation (1)
- neural computation (1)
- neural development (1)
- neuroblastoma regression (1)
- neurodevelopmental (1)
- neuroimaging (1)
- neuronal avalanches (1)
- neutropenia (1)
- neutrophils (1)
- nitric oxide (1)
- non-canonical (1)
- non-coding RNA (1)
- non-homologous end joining (1)
- non-linear dynamics (1)
- non-receptor tyrosine kinase (nRTK) (1)
- noncoding RNA (1)
- nuclear envelope (1)
- nuclear import (1)
- nuclear pore complex (1)
- obesity (1)
- older people (1)
- oncogenes (1)
- oral squamous cell carcinoma (1)
- oscillation (1)
- oxidative stress (1)
- oxygen metabolism (1)
- p22phox (1)
- p53 (1)
- p67phox (1)
- pSMAD2 (1)
- paediatric nephrology (1)
- paired continuous theta burst stimulation (1)
- parathormone (PTH) (1)
- parenting (1)
- paricalcitol (1)
- partial information decomposition (1)
- pathogenesis (1)
- patient safety (1)
- patient-derived xenograft (1)
- pediatric cancer (1)
- peg-interferon lambda (1)
- perfusion-weighted imaging (1)
- peripheral blood mononuclear cells (1)
- phagocytes (1)
- phase 2 clinical trials (1)
- pilot study (1)
- plasticity (1)
- platelet-rich fibrin (1)
- platelets (1)
- pleomorphic xanthoastrocytoma (1)
- poly-L-lysine (1)
- polymorphism (1)
- polytrauma (1)
- population-based (1)
- postnatal neurogenesis (1)
- predialysis (1)
- predictive coding (1)
- predictive timing (1)
- predictive validity (1)
- preeclampsia (1)
- premotor cortex (1)
- primary brain tumors (1)
- primary sclerosing cholangitis (1)
- proactive aggression (1)
- prognostic biomarker (1)
- progressive neoplastic disease (1)
- proliferation (1)
- prostatic cancer (1)
- protein phosphorylation (1)
- proteomics (1)
- psoriasis (1)
- psychosis (1)
- public health (1)
- pulmonary endarterectomy (1)
- pulmonary hypertension (1)
- pulmonary vein isolation (1)
- quality indicators (1)
- quantification (1)
- quantum biology (1)
- quantum neurobiology (1)
- rRNA (1)
- radiofrequency ablation (1)
- rapamycin (1)
- rare disesases (1)
- rat (1)
- reactive aggression (1)
- reactive oxygen species (1)
- realistic geometries (1)
- recommendation (1)
- reference values (1)
- regeneration (1)
- reliability (1)
- remission (1)
- remodelling (1)
- reproduction biology (1)
- research (1)
- research in academic medicine (1)
- resting-state functional connectivity (1)
- resveratrol (1)
- retinal degeneration (1)
- retinal detachment (1)
- retrospective trial (1)
- rhabdomyosarcoma (1)
- riociguat (1)
- second mitochondria-derived activator of caspases mimetic (1)
- secondary data analysis (1)
- secondary hyperparathyroidism (sHPT) (1)
- seizure (1)
- selective autophagy (1)
- self-organisation (1)
- sepsis (1)
- serum (1)
- serum concentrations (1)
- sex (1)
- sex differences (1)
- short tandem repeats (1)
- signal transducer and activator of transcription 3 (1)
- signal transducer and activator of transcription-1 (1)
- signal transduction (1)
- skill mix (1)
- skills shortage (1)
- small leucine-rich proteoglycan (1)
- soft tissue sarcoma (1)
- somatoform disorder (1)
- sphingolipid (1)
- sphingolipid metabolism (1)
- sphingolipid sphingosine-1-phosphate (1)
- sphingolipids (1)
- sphingosine 1-phosphate (1)
- sphingosine-1-phosphate (1)
- sphingosine-1-phosphate receptor (1)
- sphingosine-1-phosphate receptor 5 (1)
- staff capacity (1)
- staff fluctuation (1)
- state exams (1)
- status epilepticus (1)
- sterile α motif (SAM) (1)
- strength (1)
- structure (1)
- subject selection (1)
- supervised machine-learning (1)
- supplementary motor area (SMA) (1)
- surface marker reversion (1)
- surface-based morphometry (1)
- synaptic plasticity (1)
- synchronization (1)
- synergy (1)
- systemic sclerosis (1)
- temporal lobe epilepsy (1)
- therapy monitoring (1)
- tissue Doppler imaging (1)
- tissue at risk (1)
- toll-like receptors (1)
- tolvaptan (1)
- training program (1)
- transcranial magnetic stimulation (1)
- transcription factor (1)
- transcription factors (1)
- transcriptional regulation of autophagy (1)
- transfer (1)
- transition (1)
- transmitted founder virus (1)
- trauma (1)
- treatment choice (1)
- treatment preference (1)
- trophoblast (1)
- tuft cells (1)
- tumor progression (1)
- tumor suppressor (1)
- tumor-associated macrophages (1)
- tumor-infiltrating-lymphocytes (1)
- tumour microenvironment (1)
- type I interferon (1)
- vadimezan (1)
- vascular disrupting agents (1)
- vascular remodeling (1)
- vector-borne disease (1)
- viral dynamics (1)
- vitamin D (1)
- weight loss (1)
- whole-brain modeling (1)
- within-host viral modelling (1)
- work productivity (1)
- working conditions (1)
- working memory (1)
- wound complications (1)
- wound healing (1)
- zinc (1)
- α-synuclein (1)
Institute
Oncologic therapy is currently undergoing significant changes. A number of innovative targeted medications currently in clinical development have raised high expectations. With that in mind, discussions about terms such as "clinical benefit" and "clinical relevance" are highly topical. This also applies to further developments in the field of adjuvant systemic therapies for early-stage breast cancer. As the treatment aim is curative, assessment of the clinical benefit of adjuvant therapies must be largely based on efficacy outcomes. The focus must be on improving disease-free survival rates and lowering the risk of recurrence. Because of the current low mortality rates, statements about overall survival rates are only possible after very long observation periods. Consequently, new drugs in adjuvant therapies should be considered as offering a clinical benefit, if they reduce the risk of recurrence below current low levels of risk. The evidence for established adjuvant therapy standards in early-stage breast cancer can be used as objective criteria for comparison. This review article considers the requirements for clinical benefit of new adjuvant therapies for early breast cancer, based on examples from adjuvant endocrine therapy, adjuvant polychemotherapy and adjuvant anti-HER2 therapy.
Forensic entomology
(2017)
For many members of the forensic community, insects still have an exotic status. This may be one reason why forensic entomology, the analysis of insect evidence for forensic and legal purposes, has not yet achieved the significance it deserves in forensic sciences. The present special issue may help to change that. ...
Autophagy in cancer therapy
(2017)
Autophagy represents a catabolic program involved in the degradation of cellular components via lysosomes. It serves to mitigate cellular stress and to provide metabolic precursors especially upon starvation. Thereby, autophagy can support the survival of cancer cells. In addition, there is now convincing evidence showing that under certain conditions autophagy can also foster cell death. This dual function of autophagy is also relevant upon anticancer treatment, as many chemotherapeutic agents engage autophagy. A better understanding of the molecular mechanisms that are critical for mediating autophagic cell death in cancer cells will be instrumental to selectively interfere with this cellular program in order to increase the cancer cell’s response to cytotoxic drugs. This review illustrates how anticancer drug-induced autophagy is involved in mediating cell death.
Characterization of a novel KCNJ2 sequence variant detected in Andersen-Tawil syndrome patients
(2017)
Background: Mutations in the KCNJ2 gene encoding the ion channel Kir2.1 have been linked to the Andersen-Tawil syndrome (ATS). Molecular genetic screening performed in a family exhibiting clinical ATS phenotypes unmasked a novel sequence variant (c.434A > G, p.Y145C) in this gene. The aim of this study was to investigate the effect of this variant on Kir2.1 ion channel functionality.
Methods: Mutant as well as wild type GFP tagged Kir2.1 channels were expressed in HEK293 cells. In order to examine the effect of the new variant, electrophysiological measurements were performed using patch clamp technique. Cellular localization of the mutant in comparison to the wild type ion channel was analyzed by confocal laser scanning microscopy.
Results: The currents of cells expressing only mutant channels or a mixture of wild type and mutant were significantly reduced compared to those expressing wild type (WT) channels (p < 0.01). Whereas WT expressing cells exhibited at −120 mV an averaged current of −4.5 ± 1.9 nA, the mutant generates only a current of −0.17 ± 0.07 nA. A co-expression of mutant and WT channel generates only a partial rescue of the WT current. Confocal laser scanning microscopy indicated that the novel variant is not interfering with synthesis and/or protein trafficking.
Conclusions: The detected sequence variant causes loss-of-function of the Kir2.1 channel and explains the clinical phenotypes observed in Andersen-Tawil syndrome patients.
A recent report showed PINK1 transcript levels to be up- or down-regulated by the gain or loss of Ataxin-2 function, respectively, in human blood, in a human neural cell line and in mouse tissues. These observations may have profound implications for the regulation of cell growth and may be medically exploited for the treatment of cancer and neural atrophy...
Background: Previous magnetic resonance imaging (MRI) research suggests that, prior to the onset of psychosis, high risk youths already exhibit brain abnormalities similar to those present in patients with schizophrenia.
Objectives: The goal of the present study was to describe the functional organization of endogenous activation in young adolescents who report auditory verbal hallucinations (AVH) in view of the “distributed network” hypothesis of psychosis. We recruited 20 young people aged 13–16 years who reported AVHs and 20 healthy controls matched for age, gender and handedness from local schools.
Methods: Each participant underwent a semi-structured clinical interview and a resting state (RS) neuroimaging protocol. We explored functional connectivity (FC) involving three different networks: 1) default mode network (DMN) 2) salience network (SN) and 3) central executive network (CEN). In line with previous findings on the role of the auditory cortex in AVHs as reported by young adolescents, we also investigated FC anomalies involving both the primary and secondary auditory cortices (A1 and A2, respectively).
Further, we explored between-group inter-hemispheric FC differences (laterality) for both A1 and A2. Compared to the healthy control group, the AVH group exhibited FC differences in all three networks investigated. Moreover, FC anomalies were found in a neural network including both A1 and A2. The laterality analysis revealed no between-group, inter-hemispheric differences.
Conclusions: The present study suggests that young adolescents with subclinical psychotic symptoms exhibit functional connectivity anomalies directly and indirectly involving the DMN, SN, CEN and also a neural network including both primary and secondary auditory cortical regions.
Nepal is highly vulnerable to global climate change, despite its negligible emission of global greenhouse gases. The vulnerable climate-sensitive sectors identified in Nepal's National Adaptation Programme of Action (NAPA) to Climate Change 2010 include agriculture, forestry, water, energy, public health, urbanization and infrastructure, and climate-induced disasters. In addition, analyses carried out as part of the NAPA process have indicated that the impacts of climate change in Nepal are not gender neutral. Vector-borne diseases, diarrhoeal diseases including cholera, malnutrition, cardiorespiratory diseases, psychological stress, and health effects and injuries related to extreme weather are major climate-sensitive health risks in the country. In recent years, research has been done in Nepal in order to understand the changing epidemiology of diseases and generate evidence for decision-making. Based on this evidence, the experience of programme managers, and regular surveillance data, the Government of Nepal has mainstreamed issues related to climate change in development plans, policies and programmes. In particular, the Government of Nepal has addressed climate-sensitive health risks. In addition to the NAPA report, several policy documents have been launched, including the Climate Change Policy 2011; the Nepal Health Sector Programme – Implementation Plan II (NHSP-IP 2) 2010–2015; the National Health Policy 2014; the National Health Sector Strategy 2015–2020 and its implementation plan (2016–2021); and the Health National Adaptation Plan (H-NAP): climate change and health strategy and action plan (2016–2020). However, the translation of these policies and plans of action into tangible action on the ground is still in its infancy in Nepal. Despite this, the health sector's response to addressing the impact of climate change in Nepal may be taken as a good example for other low- and middle-income countries.
Both hemispheres contribute to motor control beyond the innervation of the contralateral alpha motoneurons. The left hemisphere has been associated with higher-order aspects of motor control like sequencing and temporal processing, the right hemisphere with the transformation of visual information to guide movements in space. In the visuomotor context, empirical evidence regarding the latter has been limited though the right hemisphere’s specialization for visuospatial processing is well-documented in perceptual tasks. This study operationalized temporal and spatial processing demands during visuomotor processing and investigated hemispheric asymmetries in neural activation during the unimanual control of a visual cursor by grip force. Functional asymmetries were investigated separately for visuomotor planning and online control during functional magnetic resonance imaging in 19 young, healthy, right-handed participants. The expected cursor movement was coded with different visual trajectories. During planning when spatial processing demands predominated, activity was right-lateralized in a hand-independent manner in the inferior temporal lobe, occipito-parietal border, and ventral premotor cortex. When temporal processing demands overweighed spatial demands, BOLD responses during planning were left-lateralized in the temporo-parietal junction. During online control of the cursor, right lateralization was not observed. Instead, left lateralization occurred in the intraparietal sulcus. Our results identify movement phase and spatiotemporal demands as important determinants of dynamic hemispheric asymmetries during visuomotor processing. We suggest that, within a bilateral visuomotor network, the right hemisphere exhibits a processing preference for planning global spatial movement features whereas the left hemisphere preferentially times local features of visual movement trajectories and adjusts movement online.
Functional imaging studies using BOLD contrasts have consistently reported activation of the supplementary motor area (SMA) both during motor and internal timing tasks. Opposing findings, however, have been shown for the modulation of beta oscillations in the SMA. While movement suppresses beta oscillations in the SMA, motor and non-motor tasks that rely on internal timing increase the amplitude of beta oscillations in the SMA. These independent observations suggest that the relationship between beta oscillations and BOLD activation is more complex than previously thought. Here we set out to investigate this rapport by examining beta oscillations in the SMA during movement with varying degrees of internal timing demands. In a simultaneous EEG-fMRI experiment, 20 healthy right-handed subjects performed an auditory-paced finger-tapping task. Internal timing was operationalized by including conditions with taps on every fourth auditory beat, which necessitates generation of a slow internal rhythm, while tapping to every auditory beat reflected simple auditory-motor synchronization. In the SMA, BOLD activity increased and power in both the low and the high beta band decreased expectedly during each condition compared to baseline. Internal timing was associated with a reduced desynchronization of low beta oscillations compared to conditions without internal timing demands. In parallel with this relative beta power increase, internal timing activated the SMA more strongly in terms of BOLD. This documents a task-dependent non-linear relationship between BOLD and beta-oscillations in the SMA. We discuss different roles of beta synchronization and desynchronization in active processing within the same cortical region.
In this study, we aimed to comparatively evaluate high-resolution 3D ultrasonography (hrUS), in-vivo micro-CT (μCT) and 9.4T MRI for the monitoring of tumor growth in an orthotopic renal cell carcinoma (RCC) xenograft model since there is a lack of validated, non-invasive imaging tools for this purpose. 1 × 106 Caki-2 RCC cells were implanted under the renal capsule of 16 immunodeficient mice. Local and systemic tumor growth were monitored by regular hrUS, μCT and MRI examinations. Cells engrafted in all mice and gave rise to exponentially growing, solid tumors. All imaging techniques allowed to detect orthotopic tumors and to precisely calculate their volumes. While tumors appeared homogenously radiolucent in μCT, hrUS and MRI allowed for a better visualization of intratumoral structures and surrounding soft tissue. Examination time was the shortest for hrUS, followed by μCT and MRI. Tumor volumes determined by hrUS, μCT and MRI showed a very good correlation with each other and with caliper measurements at autopsy. 10 animals developed pulmonary metastases being well detectable by μCT and MRI. In conclusion, each technique has specific strengths and weaknesses, so the one(s) best suitable for a specific experiment may be chosen individually.