Medizin
Refine
Year of publication
Document Type
- Article (3562) (remove)
Has Fulltext
- yes (3562) (remove)
Keywords
- inflammation (47)
- glioblastoma (29)
- apoptosis (27)
- breast cancer (26)
- cancer (26)
- Inflammation (19)
- biomarker (18)
- COVID-19 (17)
- autophagy (17)
- Depression (15)
- immunotherapy (15)
- mitochondria (15)
- Cancer (14)
- Germany (14)
- pain (14)
- Apoptosis (13)
- Breast cancer (13)
- depression (13)
- macrophage (13)
- prevention (13)
- prostate cancer (13)
- reactive oxygen species (13)
- Biomarkers (12)
- Cirrhosis (12)
- HIV (12)
- Mammakarzinom (12)
- Neuroscience (12)
- chemotherapy (12)
- Biomarker (11)
- SARS-CoV-2 (11)
- Stroke (11)
- aging (11)
- cytokines (11)
- diagnosis (11)
- epilepsy (11)
- microRNA (11)
- obesity (11)
- schizophrenia (11)
- Chemotherapy (10)
- Gene expression (10)
- Human behaviour (10)
- Mitochondria (10)
- Research article (10)
- angiogenesis (10)
- attention (10)
- cirrhosis (10)
- glioma (10)
- hypoxia (10)
- multiple sclerosis (10)
- ADHD (9)
- COPD (9)
- Children (9)
- Hemorrhage (9)
- MRI (9)
- Oncology (9)
- Primary care (9)
- Treatment (9)
- cell death (9)
- children (9)
- complications (9)
- human (9)
- invasion (9)
- leukemia (9)
- macrophages (9)
- migration (9)
- neuroblastoma (9)
- proliferation (9)
- quality of life (9)
- surgery (9)
- treatment (9)
- Atrial fibrillation (8)
- Behandlung (8)
- Evaluation (8)
- General practice (8)
- Hepatocellular carcinoma (8)
- Liver diseases (8)
- Metastasen (8)
- NADPH oxidase (8)
- Parkinson’s disease (8)
- Prognosis (8)
- Prävention (8)
- Quality of life (8)
- ROS (8)
- cognition (8)
- data science (8)
- differentiation (8)
- fMRI (8)
- mTOR (8)
- psoriasis (8)
- radiotherapy (8)
- Autophagy (7)
- Blood (7)
- Diagnostic markers (7)
- Drug therapy (7)
- Europe (7)
- HDAC (7)
- Immunotherapy (7)
- Machine learning (7)
- Multimorbidity (7)
- Outcome (7)
- Patients (7)
- Schizophrenia (7)
- Surgery (7)
- Survival (7)
- child (7)
- development (7)
- endothelial cells (7)
- epidemiology (7)
- epigenetics (7)
- hepatitis C virus (7)
- hereditary angioedema (7)
- lung cancer (7)
- macrophage polarization (7)
- medical education (7)
- metabolism (7)
- metastases (7)
- natural killer cells (7)
- proteomics (7)
- sepsis (7)
- Borrelia (6)
- CDK4/6 (6)
- Cancer treatment (6)
- Cardiovascular magnetic resonance (6)
- Death rates (6)
- Diabetes mellitus (6)
- Hepatitis C virus (6)
- Liver transplantation (6)
- Magnetic resonance imaging (6)
- Mental health and psychiatry (6)
- NASH (6)
- PD1/PDL1 (6)
- PI3K (6)
- Pain (6)
- Radiotherapy (6)
- Studien (6)
- Suicide (6)
- Surgical and invasive medical procedures (6)
- TRAIL (6)
- VEGF (6)
- bipolar disorder (6)
- brain metastases (6)
- diffusion tensor imaging (6)
- extracellular matrix (6)
- gender (6)
- infection (6)
- information theory (6)
- innate immunity (6)
- integrins (6)
- medizinische Ausbildung (6)
- metastasis (6)
- miRNA (6)
- microbiome (6)
- monocytes (6)
- mouse (6)
- neurodegeneration (6)
- outcome (6)
- particulate matter (6)
- physical activity (6)
- portal hypertension (6)
- prophylaxis (6)
- safety (6)
- targeted therapy (6)
- therapy (6)
- toxicity (6)
- ubiquitin (6)
- vitamin D (6)
- ACLF (5)
- Acute myeloid leukemia (5)
- Angiogenesis (5)
- Atherosclerosis (5)
- Cell signalling (5)
- Clinical trial (5)
- Crohn’s disease (5)
- DNA methylation (5)
- Diagnosis (5)
- EEG (5)
- EGFR (5)
- Epidemiology (5)
- Experimental models of disease (5)
- HCV (5)
- HIV-1 (5)
- Heart failure (5)
- Histology (5)
- IL-6 (5)
- MEG (5)
- Macrophages (5)
- Malaria (5)
- Medical education (5)
- Molecular biology (5)
- Morbidity (5)
- Mortality (5)
- Multiple sclerosis (5)
- Multivariate analysis (5)
- NKG2D (5)
- Non-small cell lung cancer (5)
- Obesity (5)
- Oral anticoagulation (5)
- PCR (5)
- PD-L1 (5)
- RUCAM (5)
- Smac (5)
- T cell (5)
- T cells (5)
- Targeted therapy (5)
- Trauma (5)
- Viral load (5)
- acute coronary syndrome (5)
- acute-on-chronic liver failure (5)
- adhesion (5)
- aortic stenosis (5)
- asthma (5)
- ataxia telangiectasia (5)
- atherosclerosis (5)
- atrial fibrillation (5)
- bevacizumab (5)
- biomarkers (5)
- cardiac surgery (5)
- cell therapy (5)
- chimeric antigen receptor (5)
- chronic kidney disease (5)
- cochlear implant (5)
- colorectal cancer (5)
- complement (5)
- conduct disorder (5)
- coronavirus (5)
- curcumin (5)
- cytotoxicity (5)
- efficacy (5)
- elderly (5)
- environmental tobacco smoke (5)
- fibrosis (5)
- forensic entomology (5)
- gene therapy (5)
- guideline (5)
- integrin (5)
- liver (5)
- magnetic resonance imaging (5)
- mutual information (5)
- natural killer cell (5)
- ovarian cancer (5)
- p53 (5)
- periodontitis (5)
- plasticity (5)
- polytrauma (5)
- prevalence (5)
- prognosis (5)
- regeneration (5)
- renal cell carcinoma (5)
- resistance (5)
- signal transduction (5)
- sphingosine-1-phosphate (5)
- stroke (5)
- transcranial magnetic stimulation (5)
- trauma (5)
- tumor microenvironment (5)
- valproic acid (5)
- ABCB1 (4)
- ATM (4)
- Age groups (4)
- Anticoagulation (4)
- Aortic valve (4)
- Ascites (4)
- Aspergillus fumigatus (4)
- Attention (4)
- Autism spectrum disorder (4)
- B cells (4)
- Bipolar disorder (4)
- CIK cells (4)
- CRISPR/Cas9 (4)
- Cell biology (4)
- Cell staining (4)
- Cell therapy (4)
- Clinical trials (4)
- Communication (4)
- Consensus (4)
- Cytokines (4)
- DILI (4)
- DNA damage (4)
- Decision making (4)
- Denosumab (4)
- Developmental biology (4)
- Diagnostic medicine (4)
- Diagnostik (4)
- E-Learning (4)
- Emotions (4)
- Epilepsy (4)
- Ewing sarcoma (4)
- Fibrosis (4)
- Flow cytometry (4)
- Gastric cancer (4)
- Gender (4)
- Guidelines (4)
- Hematology (4)
- Hodgkin lymphoma (4)
- Homeostasis (4)
- IAP proteins (4)
- Immunohistochemistry (4)
- Immunology (4)
- Kinematic analysis (4)
- Liver cirrhosis (4)
- MRSA (4)
- MSD (4)
- Mechanisms of disease (4)
- Medizindidaktik (4)
- MicroRNAs (4)
- Molecular medicine (4)
- Mouse models (4)
- NK cell (4)
- NK cells (4)
- NK-92 (4)
- Neonates (4)
- Neutropenia (4)
- NoxO1 (4)
- OSCE (4)
- Osteoporosis (4)
- Outcomes (4)
- Parkinson's disease (4)
- Personalized medicine (4)
- Physicians (4)
- Portal hypertension (4)
- Pregnancy (4)
- Prevention (4)
- Proliferation (4)
- Proteomics (4)
- Psychiatric disorders (4)
- Randomized controlled trial (4)
- Reactive oxygen species (4)
- Risiko (4)
- Roussel Uclaf Causality Assessment Method (4)
- Sepsis (4)
- Sex differences (4)
- Stem cells (4)
- Surgical oncology (4)
- Thrombosis (4)
- Ubiquitination (4)
- Validation (4)
- XIAP (4)
- acute kidney injury (4)
- acute lymphoblastic leukemia (4)
- adjuvant therapy (4)
- adjuvante Therapie (4)
- adolescents (4)
- aggression (4)
- alirocumab (4)
- anaemia (4)
- antibodies (4)
- antioxidants (4)
- bibliometry (4)
- cancer stem cells (4)
- cell biology (4)
- climate change (4)
- clinical trial (4)
- cytomegalovirus (4)
- dementia (4)
- dendritic cells (4)
- dental implants (4)
- direct-acting antivirals (4)
- drug resistance (4)
- early breast cancer (4)
- entropy (4)
- evaluation (4)
- faculty development (4)
- fibroblasts (4)
- frühes Mammakarzinom (4)
- gene expression (4)
- graph theory (4)
- heart failure (4)
- hematopoietic stem cell transplantation (4)
- hepatitis C (4)
- hepatocellular carcinoma (4)
- immune evasion (4)
- liver cirrhosis (4)
- liver transplantation (4)
- management (4)
- melanoma (4)
- meningioma (4)
- metabolic syndrome (4)
- mortality (4)
- p21 (4)
- pancreatic cancer (4)
- peripheral artery disease (4)
- precision medicine (4)
- pregnancy (4)
- proteome (4)
- qualitative research (4)
- radiation (4)
- radical prostatectomy (4)
- rapamycin (4)
- registry (4)
- rhabdomyosarcoma (4)
- risk (4)
- risk factors (4)
- seizure (4)
- smoking (4)
- sphingolipids (4)
- spirochetes (4)
- survival (4)
- transfusion (4)
- trials (4)
- tumor progression (4)
- tumor-associated macrophages (4)
- vector (4)
- working memory (4)
- (surface) partial differential equations (3)
- Acute inflammation (3)
- Adverse events (3)
- Aging (3)
- Allgemeinmedizin (3)
- Alzheimer's disease (3)
- Aortic valve replacement (3)
- Aspergillus (3)
- Attitude (3)
- Autism (3)
- B-cell lymphoma (3)
- BCR/ABL (3)
- BRAF (3)
- Blood pressure (3)
- Blood-brain barrier (3)
- Brain metastasis (3)
- C-reactive protein (3)
- C. elegans (3)
- CXCR3 (3)
- CXCR4 (3)
- Cancer chemotherapy (3)
- Cancer detection and diagnosis (3)
- Cancer genetics (3)
- Cardiac surgery (3)
- Cardiology (3)
- Cardiovascular disease (3)
- Catheter ablation (3)
- Cell proliferation (3)
- Chromatin accessibility (3)
- Citation analysis (3)
- Clinical competence (3)
- Clinical genetics (3)
- Cognition (3)
- Cognitive neuroscience (3)
- Cohort studies (3)
- Colorectal cancer (3)
- Complex I (3)
- Complications (3)
- Conduct disorder (3)
- Cytoskeleton (3)
- DMEK (3)
- DNase1-seq (3)
- DTI (3)
- Data processing (3)
- Data science (3)
- Decorin (3)
- Density equalizing mapping (3)
- Diabetes (3)
- Dopamine (3)
- EEG microstates (3)
- Endoscopy (3)
- Endothelial cells (3)
- European Union (3)
- Everolimus (3)
- Exercise (3)
- Eyes (3)
- FTY720 (3)
- Fingolimod (3)
- Finite Volumes (3)
- Fistula (3)
- Functional clustering (3)
- Genetics (3)
- Genome-wide association studies (3)
- Glioblastoma (3)
- Global health (3)
- HAE (3)
- HBV (3)
- HCC (3)
- HER2/neu (3)
- HNSCC (3)
- HPV (3)
- Heart (3)
- Heart transplantation (3)
- Hereditary angioedema (3)
- Hippocampus (3)
- Hospitals (3)
- Human genetics (3)
- Hypertension (3)
- IAPs (3)
- IBD (3)
- In vitro (3)
- Incidence (3)
- Inflammatory diseases (3)
- Innate immunity (3)
- Intensive care (3)
- Kidney transplantation (3)
- Knees (3)
- Knowledge (3)
- Kommunikation (3)
- LCMV (3)
- Langerhans cell histiocytosis (3)
- Language (3)
- Lehrqualifikation (3)
- Lesions (3)
- Liver fibrosis (3)
- Long non-coding RNAs (3)
- Lumbar spine (3)
- MCAK (3)
- MLL (3)
- Machine-learning (3)
- Mesenchymal stem cells (3)
- Messenger RNA (3)
- Molecular neuroscience (3)
- Morphogenesis (3)
- Motor control (3)
- Mouse (3)
- Musculoskeletal disorder (3)
- Musculoskeletal system (3)
- NF-κB (3)
- Neuroinflammation (3)
- Nivolumab (3)
- Nox4 (3)
- Observational study (3)
- PARK2 (3)
- PDGFRβ (3)
- Patient blood management (3)
- Pediatric patients (3)
- Phosphorylation (3)
- Pneumonia (3)
- Prediction (3)
- Predictive markers (3)
- Prevalence (3)
- Prostate cancer (3)
- Public health (3)
- Quantitative MRI (3)
- RITA (3)
- Radiomics (3)
- Rare diseases (3)
- Reaction time (3)
- Rectal cancer (3)
- Registries (3)
- Regression analysis (3)
- Respiration (3)
- Rheumatoid arthritis (3)
- STAT3 (3)
- Signaling (3)
- Statistical data (3)
- Stereotactic body radiation therapy (3)
- Surgeons (3)
- TKI (3)
- Tacrolimus (3)
- Tissue engineering (3)
- Torque (3)
- Training (3)
- Transcription factors (3)
- Transfusion (3)
- Translational research (3)
- Zika virus (3)
- Zoonosis (3)
- acetaminophen (3)
- adaptation (3)
- ageing (3)
- allogeneic stem cell transplantation (3)
- anal cancer (3)
- animal (3)
- anti-angiogenic therapy (3)
- antiviral (3)
- antiviral therapy (3)
- arteriogenesis (3)
- artificial intelligence (3)
- ascites (3)
- astrocytes (3)
- augmentation (3)
- autism spectrum disorder (3)
- bioinformatics (3)
- blood (3)
- body mass index (3)
- brachytherapy (3)
- breast (3)
- cGMP (3)
- cardiac (3)
- caspase-2 (3)
- caspase-8 (3)
- catheter ablation (3)
- ceramides (3)
- cerebellum (3)
- chemoresistance (3)
- cholesterol (3)
- cisplatin (3)
- clinical benefit (3)
- clinical study (3)
- clock genes (3)
- combination therapy (3)
- computational virology (3)
- connectivity (3)
- cortex (3)
- cortisol (3)
- cystic fibrosis (3)
- cytokine-induced killer cells (3)
- dental profession (3)
- dentate gyrus (3)
- dentist (3)
- diabetes mellitus (3)
- didactic (3)
- doxorubicin (3)
- drug induced liver injury (3)
- echocardiography (3)
- electroencephalography (3)
- electrolytic cleaning (3)
- endocannabinoids (3)
- endoplasmic reticulum (3)
- everolimus (3)
- exercise (3)
- exosomes (3)
- fatigue (3)
- flow cytometry (3)
- focal adhesion (3)
- functional magnetic resonance imaging (3)
- gamma (3)
- gastric cancer (3)
- head and neck cancer (3)
- health-related quality of life (3)
- hematopoietic stem and progenitor cells (3)
- herb induced liver injury (3)
- histology (3)
- histone acetylation (3)
- hyperglycemia (3)
- imaging (3)
- immune reconstitution (3)
- immunity (3)
- immunohistochemistry (3)
- immunology (3)
- impulsivity (3)
- inflammasome (3)
- iron (3)
- irradiation (3)
- leukocytes (3)
- lipocalin-2 (3)
- liver fibrosis (3)
- liver injury (3)
- lyme disease (3)
- lymphoma (3)
- mTORC1 (3)
- machine learning (3)
- mass spectrometry (3)
- massively parallel multigrid solvers (3)
- medical students (3)
- memory (3)
- mesenchymal stromal cells (3)
- mesenchymal stromal/stem cells (3)
- metastatic (3)
- metformin (3)
- miRNAs (3)
- mice (3)
- mitophagy (3)
- mitosis (3)
- molecular mechanisms (3)
- mouse model (3)
- multimorbidity (3)
- mycophenolic acid (3)
- neoadjuvant therapy (3)
- neoplasms (3)
- neuropathic pain (3)
- oncology (3)
- osteoarthritis (3)
- osteoporosis (3)
- oxidative stress (3)
- p47phox (3)
- patient blood management (3)
- perfusion (3)
- periimplantitis (3)
- platelets (3)
- polypharmacy (3)
- predictive coding (3)
- preeclampsia (3)
- primary care (3)
- primary health care (3)
- primary immunodeficiency (3)
- prognostic factors (3)
- prostaglandins (3)
- psoriatic arthritis (3)
- rat (3)
- realistic geometries (3)
- reliability (3)
- remodelling (3)
- renal cell cancer (3)
- renal function (3)
- resting state (3)
- review (3)
- rheumatoid arthritis (3)
- screening (3)
- senescence (3)
- skeletal muscle (3)
- sphingolipid (3)
- sphingosine 1-phosphate (3)
- spinal cord (3)
- stress (3)
- stress response (3)
- tobacco prevention (3)
- transplantation (3)
- tumor growth (3)
- ubiquitination (3)
- ultrasound (3)
- viral dynamics (3)
- working conditions (3)
- wound healing (3)
- 3D spatio-temporal resolved mathematical models (2)
- A/D transition (2)
- ABCC1 (2)
- ABCG2 (2)
- AKI (2)
- ALL (2)
- AML (2)
- AMPK (2)
- ATP-citrate lyase (2)
- Academic medicine (2)
- Access (2)
- Acoustics (2)
- Acute lymphocytic leukaemia (2)
- Addison’s disease (2)
- Adenocarcinoma (2)
- Adipose tissue (2)
- Adipose-derived mesenchymal stem cells (2)
- Adolescents (2)
- Adults (2)
- Alcohol consumption (2)
- Alcoholic liver disease (2)
- Alleles (2)
- Allergic asthma (2)
- Allergy (2)
- Alpelisib (2)
- Alzheimer (2)
- Alzheimer’s disease (2)
- Amblyopia (2)
- Anemia (2)
- Antibodies (2)
- Anticoagulant therapy (2)
- Antiretroviral therapy (2)
- Antiretrovirals (2)
- Antiviral therapy (2)
- Aortic dissection (2)
- Apheresis (2)
- Artificial intelligence (2)
- Asphyxia (2)
- Assessment (2)
- Atezolizumab (2)
- Aurora A (2)
- Austria (2)
- Autopsy (2)
- BCL2 (2)
- BCL6 (2)
- BDNF (2)
- BMC (2)
- BRCA1 (2)
- BRCA2 (2)
- BRD4 (2)
- Babesia divergens (2)
- Babesia microti (2)
- Bacterial infection (2)
- Benefit (2)
- Big Data (2)
- Biochemistry (2)
- Bioinformatics (2)
- Biopsy (2)
- Biosynthetic mesh (2)
- Bladder cancer (2)
- Blood groups (2)
- Body mass index (2)
- Bone defect (2)
- Bone marrow (2)
- Bone marrow-derived mesenchymal stem cells (2)
- Bone regeneration (2)
- Bone tissue engineering (2)
- Brain tumor (2)
- Breast neoplasms (2)
- Breast tumors (2)
- Brustkrebs (2)
- Burden of disease (2)
- C1 inhibitor (2)
- CAD/CAM (2)
- CAR (2)
- CBA (2)
- CC16 (2)
- CD19 (2)
- CD36 (2)
- CDKN1A (2)
- CLP (2)
- CPE (2)
- CT (2)
- CTGF (2)
- CUELA (2)
- CV9202 (2)
- CXCL12 (2)
- Calcium (2)
- Callous-unemotional traits (2)
- Cancer epidemiology (2)
- Cancer genomics (2)
- Cancer models (2)
- Candida (2)
- Cannabidiol (2)
- Cannabis (2)
- Capecitabine (2)
- Capsule endoscopy (2)
- Cardiac hypertrophy (2)
- Cardiac magnetic resonance (2)
- Cardioprotection (2)
- Cardiovascular diseases (2)
- Case management (2)
- Cats (2)
- Causality assessment (2)
- Celiac disease (2)
- Cell binding (2)
- Cell differentiation (2)
- Cell salvage (2)
- Cerebrospinal fluid (2)
- Cesarean section (2)
- Chaperone (2)
- Checkpoint inhibitor (2)
- Chemical biology (2)
- Chemoradiotherapy (2)
- Chronic disease (2)
- Chronic diseases (2)
- Chronic hepatitis (2)
- Chronic kidney disease (2)
- Chronic obstructive pulmonary disease (2)
- Clinical presentation (2)
- Clinical studies (2)
- Clinical study (2)
- Cocaine (2)
- Cognitive behavioral therapy (2)
- Cognitive impairment (2)
- Community based intervention (2)
- Compliance (2)
- Complication management (2)
- Connective tissue (2)
- Coronary heart disease (2)
- Cortex (2)
- Costs (2)
- Croatia (2)
- Crohn's disease (2)
- Crystal structure (2)
- CspZ (2)
- Cuela (2)
- CyberKnife robotic radiosurgery (2)
- Cytogenetics (2)
- Cytoskeletal proteins (2)
- DAA (2)
- DMARDs (biologic) (2)
- DNA damage response (2)
- DNA mismatch repair (2)
- DSM (2)
- Daptomycin (2)
- Data visualization (2)
- Decision (2)
- Decision trees (2)
- Dentist (2)
- Dentistry (2)
- Deutschland (2)
- Diagnose (2)
- Diagnostics (2)
- Differentiation (2)
- Digestive system procedures (2)
- Direct current electrical stimulation (2)
- Disease Activity (2)
- Docetaxel (2)
- Dose response (2)
- Dravet syndrome (2)
- Drug development (2)
- Drug resistance (2)
- E3 ligase (2)
- ECMO (2)
- EEG-fMRI (2)
- ENCODE-DREAM in vivo Transcription Factor binding site prediction challenge (2)
- EQ-5D (2)
- Ears (2)
- Eccentric fixation (2)
- Education (2)
- Efficiency (2)
- Ejection fraction (2)
- Elderly (2)
- Electroencephalography (2)
- Emotion regulation (2)
- EndMT (2)
- Endothelial permeability (2)
- Ensemble learning (2)
- Enzyme-linked immunoassays (2)
- Epidermal growth factor receptor (2)
- Epigenetics (2)
- Epstein-Barr virus (2)
- Ergonomics (2)
- Etiology (2)
- Evidence-based medicine (2)
- Extended donor criteria (2)
- Extracellular matrix (2)
- Eye movements (2)
- Face (2)
- Family practice (2)
- Fatty liver (2)
- Fibroblasts (2)
- Flaps (2)
- Forensic entomology (2)
- Fortbildung (2)
- Frailty (2)
- Früherkennung (2)
- Frühgeburt (2)
- Functional magnetic resonance imaging (2)
- Funding (2)
- G-CSF (2)
- GFAP (2)
- GWAS (2)
- Gadobutrol (2)
- Galaktografie (2)
- Galaktomosynthese (2)
- Gene regulation (2)
- Gene therapy (2)
- General practitioners (2)
- Genetic testing (2)
- Genetics research (2)
- German people (2)
- Glucose metabolism (2)
- Grafts (2)
- Growth factors (2)
- HDACi (2)
- HER2 (2)
- HOD (2)
- HSCT (2)
- HSV (2)
- Head and neck cancer (2)
- Health economics (2)
- Health services research (2)
- Healthcare worker (2)
- Hematologic malignancies (2)
- HepG2 (2)
- Hepatocytes (2)
- Herb induced liver injury (2)
- High-density lipoprotein (2)
- Hirnforschung (2)
- Holmes tremor (2)
- Hypoxia (2)
- ICU (2)
- IHC (2)
- IL-10 (2)
- IL-1β (2)
- IR-A (2)
- Image analysis (2)
- Immune suppression (2)
- Implementation (2)
- Incisional hernia (2)
- Indirect-binding (2)
- Infection (2)
- Infection control (2)
- Infectious diseases (2)
- Inflammatory bowel disease (2)
- Intensive care units (2)
- Interdisciplinarity (2)
- Interleukin-22 (2)
- Interleukin-6 (2)
- Internet (2)
- Iron deficiency anemia (2)
- Ischemia (2)
- Ischemia/reperfusion injury (2)
- Jaw (2)
- KGF (2)
- Katherine (2)
- Klebsiella pneumoniae (2)
- Klinische Kompetenz (2)
- Kompetenzen (2)
- L2 (2)
- LPS (2)
- LVAD (2)
- Labor and delivery (2)
- Left hemisphere (2)
- Legs (2)
- Leukemias (2)
- Linear regression analysis (2)
- Lipid signalling (2)
- Liver Transplantation (2)
- Lokalrezidiv (2)
- Long-term care (2)
- Longitudinal (2)
- Low back pain (2)
- Luciferase (2)
- Lyme disease (2)
- Lymph nodes (2)
- Lymphocytes (2)
- Lysosome (2)
- MALAT1 (2)
- MCAO (2)
- MCI (2)
- MICA (2)
- MMP9 (2)
- MRT (2)
- MYC (2)
- Macroautophagy (2)
- Mamma (2)
- Markovianity (2)
- Masquelet technique (2)
- Mass spectrometry (2)
- Maxillary sinus (2)
- Medical risk factors (2)
- Medication Appropriateness Index (2)
- Medicine (2)
- Medizinstudium (2)
- Meldepflicht (2)
- Membrane potential (2)
- Mesh (2)
- Metastatic breast cancer (2)
- Microbiome (2)
- Microsurgery (2)
- Migrants (2)
- Minimal residual disease (2)
- Mitosis (2)
- MitraClip (2)
- Mixed methods (2)
- Molecular profiling (2)
- Morphometry (2)
- Multidrug resistance (2)
- Multiple chronic conditions (2)
- Musculoskeletal diseases (2)
- Mutation (2)
- Myocardial infarction (2)
- NADH:ubiquinone oxidoreductase (2)
- NAFLD (2)
- NK cells (2)
- NOTCH1 (2)
- Nachsorge (2)
- Neoplasms (2)
- Nepal (2)
- Nerve fibers (2)
- Nerve regeneration (2)
- Neural circuits (2)
- Neuroimaging (2)
- Neurology (2)
- Neuronal morphology (2)
- Neurons (2)
- Nevirapine (2)
- Next-generation sequencing (2)
- Nitric oxide (2)
- Non-REM sleep (2)
- Non-interventional study (2)
- Normal distribution (2)
- Nox (2)
- Nox1 (2)
- Nrf2 (2)
- OSPE (2)
- Occlusion treatment (2)
- Operation/Chirurgie (2)
- Ophthalmology (2)
- Optogenetics (2)
- Oral surgery (2)
- Organ dysfunction (2)
- Organ dysfunctions (2)
- Oroantral (2)
- Osteogenic differentiation (2)
- Outcome assessment (2)
- Ovarian cancer (2)
- Oxidative stress (2)
- P600 (2)
- PARP (2)
- PD1/ PDL1 (2)
- PD‑L1 (2)
- PET (2)
- PINK1 (2)
- Palliative care (2)
- Palliative care [MeSH] (2)
- Parkin (2)
- Parkinson disease (2)
- Patient-centred care (2)
- Pediatric (2)
- Pediatric infections (2)
- Percutaneous coronary intervention (2)
- Periodontitis (2)
- Peritonitis (2)
- Persistence (2)
- Personal- und Organisationsentwicklung (2)
- Philadelphia chromosome (2)
- Phylogenetic analysis (2)
- Physiology (2)
- Plasmodium (2)
- Platelet-rich fibrin (2)
- Platelets (2)
- Plerixafor (2)
- Plk1 inhibitors (2)
- Podospora anserina (2)
- Polypharmacy (2)
- Portal veins (2)
- Post-translational modifications (2)
- Postoperative radiochemotherapy (2)
- Postural control (2)
- Practical skills (2)
- Professionalisierung (2)
- Prognosefaktoren (2)
- Prognostic (2)
- Prognostic markers (2)
- Programm (2)
- Progranulin (2)
- Prophylaxis (2)
- Prostatic neoplasms (2)
- Protease inhibitor therapy (2)
- Proteasome (2)
- Protein translation (2)
- Prädiktivfaktoren (2)
- Psychology (2)
- Pulmonary hypertension (2)
- Pulmonary veins (2)
- Quality of care (2)
- Questionnaires (2)
- RIPK3 (2)
- RNA binding proteins (2)
- RNA interference (2)
- RNA interference (RNAi) (2)
- RNA isolation (2)
- Red blood cell transfusion (2)
- Regeneration (2)
- Register (2)
- Registry (2)
- Reliabilität (2)
- Renal cell carcinoma (2)
- Renal system (2)
- Research architecture (2)
- Respiratory chain (2)
- Rhabdomyosarcoma (2)
- Rheumatoid Arthritis (2)
- Richtlinie (2)
- Roussel Uclaf Causality Assessment Method (RUCAM) (2)
- S1P (2)
- SARS (2)
- SARS‐CoV‐2 (2)
- SD-OCT (2)
- SKAP1 (2)
- SPTAN1 (2)
- STING (2)
- Safety (2)
- Sarcoidosis (2)
- Sarcoma (2)
- Schmerz (2)
- Scientists (2)
- Screening (2)
- Senescence (2)
- Sensory processing (2)
- Sestrin 2 (2)
- Simulated patients (2)
- Skills (2)
- Sleep (2)
- Social participation (2)
- Socioeconomic status (2)
- Sorafenib (2)
- Sphingolipids (2)
- Sports and exercise medicine (2)
- Staff development (2)
- Stem cell (2)
- Stem-cell therapies (2)
- Strength training (2)
- Streptococcus pneumoniae (2)
- Structural plasticity (2)
- Study protocol (2)
- Subarachnoid hemorrhage (2)
- Sunitinib (2)
- Superoxide (2)
- Supportivtherapie (2)
- Survival analysis (2)
- Survivin (2)
- Sweden (2)
- Synaptic plasticity (2)
- Systematic reviews (2)
- TBSS (2)
- TF-complexes (2)
- TGFβ (2)
- Target identification (2)
- Teeth (2)
- Tele-EEG (2)
- Tenofovir (2)
- Thailand (2)
- Therapie (2)
- Therapy (2)
- Thermoregulation (2)
- Thoracic trauma (2)
- Thromboembolism (2)
- Thrombolysis (2)
- Toll-like receptor (2)
- Tomosynthese (2)
- Toxicity (2)
- Transarterial chemoembolization (2)
- Transcription Factors (2)
- Transmission (2)
- Traumatic injury (2)
- Treatment outcome (2)
- Tumor microenvironment (2)
- T‑DM1 (2)
- Ulcerative colitis (2)
- Ultraschall (2)
- Ultrasonography (2)
- Ultrasound (2)
- Urology (2)
- VDR (2)
- VIGALL (2)
- Vaccination (2)
- Validität (2)
- Vascularization (2)
- Veins (2)
- Video (2)
- Vision (2)
- Visual acuity (2)
- Vitamin D (2)
- Vitamin D deficiency (2)
- Vmem (2)
- Warburg effect (2)
- Working memory (2)
- Wound healing (2)
- Wundheilung (2)
- abuse (2)
- acetyl-CoA (2)
- acute decompensation (2)
- acute lung injury (2)
- acute myeloid leukaemia (2)
- acute myeloid leukemia (2)
- adalimumab (2)
- additives (2)
- adenosine (2)
- adenovirus (2)
- adherence (2)
- adipose-derived mesenchymal stem cells (2)
- admission test (2)
- adoptive cancer immunotherapy (2)
- advanced (2)
- advanced care planning (2)
- adverse reaction (2)
- age (2)
- age-related macular degeneration (2)
- aged (2)
- air flow (2)
- albumin (2)
- alcohol (2)
- alpelisib (2)
- alveolar ridge augmentation (2)
- analgesics (2)
- animal experiment (2)
- animal models (2)
- antibacterial activity (2)
- antibiotic therapy (2)
- anticonvulsants (2)
- antiepileptic drugs (2)
- antisocial behavior (2)
- arousal (2)
- arthritis (2)
- astrocytoma (2)
- atezolizumab (2)
- audiovisual (2)
- autoimmune diabetes (2)
- autoimmune disease (2)
- autoimmunity (2)
- autologous stem cell transplantation (2)
- behavior (2)
- betulinic acid (2)
- biocompatibility (2)
- biologics (2)
- biopsy (2)
- blood flow restriction (2)
- bone healing (2)
- bone metabolism (2)
- borrelia (2)
- brain imaging (2)
- brain states (2)
- brain-derived neurotrophic factor (2)
- brainstem (2)
- burden of illness (2)
- cAMP (2)
- cART (2)
- calcitriol (2)
- calretinin (2)
- cancer immunotherapy (2)
- capsaicin (2)
- carbapenemase (2)
- carbapenemases (2)
- cardiovascular (2)
- cardiovascular disease (2)
- case-referent study (2)
- cell migration (2)
- cell motility (2)
- cell proliferation (2)
- cells (2)
- ceramide (2)
- cerebrospinal fluid (2)
- cervical cancer (2)
- chemokines (2)
- chemoradiotherapy (2)
- chemotherapy resistance (2)
- chest trauma (2)
- chronic myeloid leukemia (2)
- chronic thromboembolic pulmonary hypertension (2)
- cigarette (2)
- circadian (2)
- circadian rhythm (2)
- circadian rhythms (2)
- cisplatin resistance (2)
- citation (2)
- classical Hodgkin lymphoma (2)
- cleaning (2)
- clinical research (2)
- clinical studies (2)
- cochlea (2)
- collagen (2)
- colon cancer (2)
- colon carcinoma cells (2)
- colorectal carcinoma (2)
- communication (2)
- complementary and alternative medicine (2)
- complex I (2)
- compliance (2)
- computed tomography (2)
- continuous performance test (2)
- corneal edema (2)
- corneal transplantation (2)
- coronary artery bypass graft surgery (2)
- coronary artery disease (2)
- critical care (2)
- criticality (2)
- cryoballoon (2)
- cyclooxygenase (2)
- cyclosporin A (2)
- cytochrome P450 2E1 (2)
- cytotoxic T cells (2)
- dabrafenib (2)
- deafness (2)
- decision making (2)
- decompensated liver cirrhosis (2)
- dental assistants (2)
- dental education (2)
- dental implant (2)
- dentists (2)
- detoxification (2)
- diabetes (2)
- dietary supplements (2)
- dihydroceramide (2)
- disease models (2)
- disintegration (2)
- distress (2)
- drug discovery (2)
- drug release (2)
- drug-induced liver injury (2)
- dual task (2)
- e-Learning (2)
- eLearning (2)
- education (2)
- eicosanoids (2)
- elderly patients (2)
- electrocardiography (2)
- electron transport chain (2)
- encoding (2)
- endothelial (2)
- endothelial cell (2)
- entorhinal cortex lesion (2)
- epigenetic (2)
- epileptogenesis (2)
- esophageal cancer (2)
- event-related potentials (2)
- expertise (2)
- extraversion (2)
- factor H (2)
- fasting (2)
- feedback (2)
- femoral artery ligation (2)
- fenfluramine (2)
- follow‑up (2)
- fortgeschritten (2)
- fracture (2)
- functional connectivity (2)
- functional genetics (2)
- functional genomics (2)
- gait analysis (2)
- galactography (2)
- galactomosynthesis (2)
- gene regulation (2)
- general practice (2)
- genetics (2)
- glucose metabolism (2)
- growth (2)
- growth factor (2)
- growth inhibition (2)
- guidelines (2)
- health (2)
- health information exchange (2)
- heart rate (2)
- hedgehog signaling (2)
- hematopoiesis (2)
- hematopoietic stem cells (2)
- hemodialysis (2)
- hemolysis (2)
- hepatic encephalopathy (2)
- hepatitis B (2)
- hepatitis C virus (HCV) (2)
- herbal hepatotoxicity (2)
- hippocampus (2)
- histological validation (2)
- histone deacetylase inhibitor (2)
- human biology and medicine (2)
- human cytomegalovirus (2)
- hyperactivity (2)
- hyperhomocysteinemia (2)
- iDILI (2)
- iPS (2)
- immune escape (2)
- immune response (2)
- immune system (2)
- immunocytochemistry (2)
- in vitro (2)
- induced membrane (2)
- inertial motion capture (2)
- infiltration (2)
- inflammatory bowel disease (2)
- inner ear (2)
- insulin resistance (2)
- integration (2)
- interferon (2)
- interferon gamma (2)
- interleukin-18 (2)
- interleukin-22 (2)
- interleukin-4 (2)
- interleukins (2)
- invasive fungal disease (2)
- invasive fungal infection (2)
- job-exposure matrix (2)
- kidney (2)
- kidney transplantation (2)
- kinase inhibitor (2)
- kinase regulation (2)
- kinematics (2)
- klinischer Nutzen (2)
- knowledge discovery (2)
- lapatinib (2)
- leukopenia (2)
- levetiracetam (2)
- lipoxygenase (2)
- liver disease (2)
- liver metastases (2)
- lncRNA (2)
- local control (2)
- local information dynamics (2)
- local recurrence (2)
- long-term prophylaxis (2)
- long-term survival (2)
- longevity (2)
- lung function (2)
- machine-learning (2)
- magnetoencephalography (2)
- maintenance (2)
- mandatory reporting (2)
- marginal bone loss (2)
- mathematical modeling (2)
- mathematical models of viral RNA cycle (2)
- matrix (2)
- medical studies (2)
- melatonin (2)
- metabolomics (2)
- methylprednisolone (2)
- microdosing (2)
- microenvironment (2)
- microglia (2)
- microwave ablation (2)
- mild cognitive impairment (2)
- minimalinvasive Biopsie (2)
- minimally invasive biopsies (2)
- mitochondrial disease (2)
- modeling (2)
- modularity (2)
- molecular mimicry (2)
- morphogenesis (2)
- motility (2)
- multidrug resistance (2)
- multinucleated giant cells (2)
- musculoskeletal (2)
- musculoskeletal disorders (2)
- music (2)
- myelodysplastic syndrome (2)
- nanoparticles (2)
- natural product (2)
- necroptosis (2)
- neoadjuvant chemotherapy (2)
- neoadjuvante Chemotherapie (2)
- neoadjuvante Therapie (2)
- neonate (2)
- network analysis (2)
- neural network (2)
- neural oscillations (2)
- neurocritical care (2)
- neurogenesis (2)
- neuroimaging (2)
- neuromodulation (2)
- neurophysiology (2)
- neuroticism (2)
- neutrophils (2)
- newborn (2)
- next generation sequencing (2)
- next generation sequencing (NGS) (2)
- nitric oxide (2)
- non-coding RNA (2)
- nursery schools (2)
- nutlin-3 (2)
- observational study (2)
- occupational exposure (2)
- occupational health (2)
- omega-3 fatty acids (2)
- oncogene (2)
- oscillations (2)
- osteogenesis (2)
- outcomes (2)
- overall survival (2)
- overweight (2)
- paclitaxel (2)
- paired associative stimulation (2)
- palatal tremor (2)
- pandemic (2)
- partial information decomposition (2)
- patient (2)
- patient safety (2)
- patient triage (2)
- pelvic packing (2)
- peptide aptamer (PA) (2)
- perception (2)
- perforant path transection (2)
- peri‐implantitis (2)
- phagocytosis (2)
- pharmacodynamics (2)
- pharmacoresistance (2)
- pharmacovigilance (2)
- phosphate (2)
- plasmid (2)
- platelet-rich fibrin (2)
- polo-like kinase 1 (2)
- poly(lactic-co-glycolic acid) (PLGA) (2)
- polygenic risk score (2)
- polymerase chain reaction (2)
- polymorphism (2)
- population dynamics (2)
- postoperative complications (2)
- posttraumatic stress disorder (2)
- predictive factors (2)
- prefrontal cortex (2)
- preterm birth (2)
- primary cilium (2)
- primary sclerosing cholangitis (2)
- prognostic value (2)
- prostaglandin (2)
- proteasome inhibitor (2)
- protein kinase (2)
- protein quality control (2)
- proteoglycan (2)
- proximal tubule (2)
- psychophysiology (2)
- psychosis (2)
- public health (2)
- pulmonary hypertension (2)
- pulmonary vein isolation (2)
- quality (2)
- quality assurance (2)
- quantitative MRI (2)
- questionnaire (2)
- rare diseases (2)
- re-osseointegration (2)
- real-world data (2)
- recommendations (2)
- reference values (2)
- reproducibility (2)
- research (2)
- revision surgery (2)
- ribavirin (2)
- risk prediction (2)
- rituximab (2)
- school-based prevention (2)
- scientometrics (2)
- scientometry (2)
- second-hand smoke (2)
- secretion (2)
- secretome (2)
- secukinumab (2)
- seizures (2)
- sensory neuropathy (2)
- severe acute respiratory syndrome coronavirus 2 (2)
- sex (2)
- sex differences (2)
- short essay questions (2)
- shunt (2)
- siRNA (2)
- signal transducer and activator of transcription 5 (Stat5) (2)
- signaling (2)
- signature (2)
- simulation (2)
- simulation training (2)
- single-sided deafness (2)
- skin (2)
- sleep (2)
- smoking cessation (2)
- soft tissue sarcoma (2)
- soluble MICA (2)
- spiking neural networks (2)
- spreadsheet (2)
- stability (2)
- stationarity (2)
- status epilepticus (2)
- stem cell transplantation (2)
- studies (2)
- sulforaphane (2)
- supportive therapy (2)
- surgical procedures (2)
- survival rate (2)
- survivin (2)
- synchronization (2)
- synchrony (2)
- synergy (2)
- systematic review (2)
- telemedicine (2)
- temozolomide (2)
- temperature (2)
- temporal lobe epilepsy (2)
- temsirolimus (2)
- therapy monitoring (2)
- therapy resistance (2)
- thymus (2)
- tissue Doppler imaging (2)
- tobacco (2)
- tobacco smoke (2)
- tomosynthesis (2)
- training (2)
- transcriptome (2)
- transient elastography (2)
- trastuzumab (2)
- treatment/therapy (2)
- trophoblast (2)
- tumor angiogenesis (2)
- tumor infiltrating lymphocytes (2)
- tumor suppressor (2)
- tumor-infiltrating lymphocytes (2)
- undergraduate medical education (2)
- ustekinumab (2)
- uteroglobin (2)
- vaccination (2)
- vaccine (2)
- validity (2)
- vemurafenib (2)
- vitamin B deficiency (2)
- von Willebrand factor (2)
- weight loss (2)
- within-host viral modelling (2)
- workflow (2)
- zebrafish (2)
- zinc (2)
- (cardiac) surgery (1)
- (novel) brominated flame retardants ((N)BFR) (1)
- 1,2-dichloroethane (1)
- 1,25-Dihydroxyvitamin D (1)
- 14-3-3 gene family (1)
- 15-PGDH (1)
- 16 segment AHA model (1)
- 16S rRNA sequencing (1)
- 16p11.2 (1)
- 17-AAG (1)
- 17‐OH itraconazole (1)
- 19F MR spectroscopy (1)
- 1H MR spectroscopy (1)
- 1α,25(OH)2D3 (1)
- 2-deoxyglucose (2-DG) (1)
- 2-hydroxyglutarate (1)
- 2019-nCoV (1)
- 2‑methoxyestradiol (1)
- 3-hydroxyanthranilic acid (1)
- 32D progenitor cells (1)
- 3Cs technology (1)
- 3D printed cell-free scaffold (1)
- 3D printing (1)
- 3D rapid prototyping (1)
- 3D spatiotemporal resolved mathematical models (1)
- 3D tissue models (1)
- 3years (1)
- 4-1BB (1)
- 4-FA (1)
- 5 lipoxygenase (1)
- 5' UTR (1)
- 5-lipoxygenase (1)
- 6-Schritt-Methode (1)
- 90% or more improvement in baseline Psoriasis Area and Severity Index (1)
- 99mTc-MIBI (1)
- 99mTc-pertechnetate (1)
- A-FFIP (1)
- A-PRF+ (1)
- A2BP1 (1)
- A375 human melanoma cell line (1)
- A375 human melanoma cells (1)
- A549 (1)
- AA-amylodosis (1)
- AB-serum (1)
- ABS (1)
- ABT-737 (1)
- ACE-Bestimmung (1)
- ACE-inhibitor (1)
- ACL (1)
- ACURATE neo (1)
- ADAM-17 (1)
- ADAM10 (1)
- ADAM15 (1)
- ADAMTS-13 (1)
- ADHD differential diagnosis (1)
- AGC kinase (1)
- AICAR (1)
- AIDS (1)
- AIH immunopathogenesis (1)
- AIS (1)
- AJAP1 (1)
- ALF (1)
- ALK gene (1)
- ALK-rearranged NSCLC (1)
- AMD3100 (1)
- AMH (1)
- AML – acute myeloid leukemia (1)
- AMP-activated kinase (1)
- AOSpine (1)
- AOSpine injury score (1)
- APMPPE - acute posterior multifocal placoid pigment epitheliopathy (1)
- APP (1)
- APP processing (1)
- APRI (1)
- ARA (1)
- ARDS (1)
- ARID5B (1)
- ASA404 (1)
- ASAP (1)
- ASCT (1)
- ASD-specific (1)
- ASO (1)
- AT-101 (1)
- ATO (1)
- ATP (1)
- ATXN2 (1)
- AVM hemorrhage (1)
- AZD7762 (1)
- Abatacept (1)
- Abdominal aortic aneurysm (1)
- Abdominal infections (1)
- Abdominal surgery (1)
- Abdominal trauma (1)
- Abdominelles Aortenaneurysma (1)
- Abiraterone acetate (1)
- Abl kinase inhibitors (1)
- Absenteeism (1)
- Academic health centres (1)
- Academics (1)
- Accelerometry (1)
- Accessibility (1)
- Acellular dermis (1)
- Acer platanoides (1)
- Acid ceramiase (1)
- Acquired drug resistance (1)
- Actin (1)
- Actinomycin D (1)
- Action potential (1)
- Activities of daily living (1)
- Activity control (1)
- Acute HIV infection (1)
- Acute Hemiparesis (1)
- Acute Myeloid Leukemia (1)
- Acute Myeloid Leukemia (AML) (1)
- Acute bronchitis (1)
- Acute calcolous cholecystitis (1)
- Acute coronary syndrome (1)
- Acute cough (1)
- Acute decompensation (1)
- Acute heart failure (1)
- Acute hospital (1)
- Acute leukemia (1)
- Acute lymphoblastic leukemia (1)
- Acute myeloid leukaemia (1)
- Acute-on-chronic liver failure (1)
- Adenylyl cyclase (1)
- Adherence (1)
- Adherence junctions (1)
- Adhesion (1)
- Adipose tissue-derived mesenchymal stem cells (1)
- Adjustment of dosage at steady state (1)
- Adjuvant therapies (1)
- Adolescence (1)
- Adult (1)
- Adult T-cell acute lymphoblastic leukemia (1)
- Adult neurogenesis (1)
- Advanced biliary tract cancer (1)
- Advanced breast cancer (1)
- Advanced glycation endproducts (1)
- Adverse drug reaction (1)
- Aedes aegypti (1)
- Aedes albopictus (1)
- Affective disorders (1)
- Africa (1)
- Age (1)
- Age determination by skeleton (1)
- Aggregation (1)
- Aggressive periodontitis (1)
- Agoraphobia (1)
- Agreement (1)
- Air traffic (1)
- Airways (1)
- Akaike information criterion (AIC) (1)
- Akute Leukämie (1)
- Akutes Koronarsyndrom (1)
- Algorithms (1)
- Aliphatic halogenated hydrocarbons (1)
- Alisertib (1)
- All oral (1)
- All-trans retinoic acid (1)
- Allergen immunotherapy (1)
- Allergic rhinitis (1)
- Allergoid (1)
- Allochromatium vinosum (1)
- Allogeneic Stem Cell Transplantation (SCT) (1)
- Allogeneic hematopoietic stem (1)
- Allogeneic stem cell transplantation (1)
- Allograft bone block (1)
- Allosteric inhibition (1)
- Alpha oscillations (1)
- Alpha-synuclein (1)
- Alpha-synuclein deficiency (1)
- Alternative oxidase (1)
- Alveolar ridge augmentation (1)
- Alzheimer’s dementia (1)
- Ambroxol (1)
- Ameloblastoma (1)
- Amino acid analysis (1)
- Aminosäuremetabolismus (1)
- Aminosäuren (1)
- Aminotransferases (1)
- Amizon (1)
- Amygdala (1)
- Amyloid precursor protein (1)
- Amyloid-beta 42 (1)
- Amyotrophic lateral sclerosis (1)
- Anaemia (1)
- Anaesthesia (1)
- Anal cancer (1)
- Anamneseerhebung (1)
- Anaplastic astrocytoma (1)
- Anatomic competence (1)
- Anatomie (1)
- Anatomie und Histologie (1)
- Anatomy (1)
- Andersen-Tawil syndrome (1)
- Andexanet alpha (1)
- Andropogon virginicus (1)
- Anesthesia, Intravenous (1)
- Aneurysm (1)
- Aneurysmal subarachnoid hemorrhage (1)
- Aneurysms (1)
- Angioedema (1)
- Angiogenèse (1)
- Angiography (1)
- Angioplasty (1)
- Angiotensin Converting Enzyme (1)
- Angiotensin-converting enzyme (1)
- Animal wings (1)
- Ankle arthrometer (1)
- Anopheles (1)
- Anosmia (1)
- Antagonist (1)
- Antarctic marine sponges (1)
- Anterior cingulate cortex (1)
- Anterior cruciate ligament reconstruction (1)
- Anti platelet therapy (1)
- Anti-CMV IgG (1)
- Anti-Müller-Hormon (1)
- Anti-TNF (1)
- Anti-tumor immunity (1)
- Antiangiogenesis (1)
- Antibiotic (1)
- Antibiotic generic drugs (1)
- Antibiotic stewardship (1)
- Antibiotic therapy (1)
- Antibiotics (1)
- Antibody isotypes (1)
- Antibody-mediated rejection (1)
- Anticoagulants (1)
- Anticoagulants [MeSH] (1)
- Antidepressant (1)
- Antifungal agents (1)
- Antigen-presenting cells (1)
- Antigens (1)
- Antihormone therapy (1)
- Antimicrobial resistance (1)
- Antimicrobial treatment (1)
- Antiplatelet therapy (1)
- Antireflux surgery (1)
- Antirheumatic agents (1)
- Antithrombotic therapy (1)
- Antivenom (1)
- Antiviral agents (1)
- Antiviral immune response (1)
- Antiviral response (1)
- Anura (1)
- Anxiety (1)
- Aortic Valve Replacement (1)
- Aortic arch replacement (1)
- Aortic debranching (1)
- Aortic stenosis (1)
- Aortic stiffness (1)
- Aortic valve sparing (1)
- Apes (1)
- Apixaban (1)
- Aquaporins (1)
- Arabin pessary (1)
- Arabin-Pessar (1)
- Area deprivation (1)
- Arms (1)
- Aromatase Inhibitors (1)
- Arrhythmia (1)
- Arrhythmia/all (1)
- Artemether-lumefantrine (1)
- Artemisinin-combination-therapy (1)
- Arteriogenesis (1)
- Artesunate (1)
- Arthroscopy (1)
- Asian bush mosquito (1)
- Aspergillosis (1)
- Aspergillus species (1)
- Assay variation (1)
- Assessment of care (1)
- Asthma (1)
- Asthma and allergic disorders (1)
- Astrocytoma grades (1)
- Ataxia (1)
- Ataxia telangiectasia (1)
- Ataxia-telangiectasia (1)
- Atazanavir (1)
- Atelopus carbonerensis (1)
- Atelopus mucubajiensis (1)
- Atelopus tamaense (1)
- Atención centrada en el paciente (1)
- Atrial appendage occlusion (1)
- Atrial function (1)
- Attack (1)
- Attention Deficit Hyperactivity Disorder (1)
- Attention-deficit / hyperactivity disorder (1)
- Atxn2 (1)
- Audio equipment (1)
- Audio signal processing (1)
- Audiology (1)
- Auditory (1)
- Auditory cortex (1)
- Auditory system (1)
- Auric nanoparticles (1)
- Aurora (1)
- Aurora Ax (1)
- Aurora kinase inhibitor (1)
- Australia (1)
- Autism spectrum disorders (1)
- Autistic Behavior (1)
- Autistic disorder (1)
- Auto transfusion (1)
- Autogenous bone block (1)
- Autoimmune encephalomyelitis (1)
- Autoimmunity (1)
- Autologous stem cell transplantation (1)
- Automated Tube Potential Selection (1)
- Automatic Environmental Tobacco Smoke Emitter (1)
- Autonomic nervous system (1)
- Autosomal recessive cutis laxa type 1C (1)
- Awareness (1)
- Axon (1)
- Axons (1)
- Azacitidine (1)
- Azan trichrome stain (1)
- Azathioprine (1)
- Azidothymidine (1)
- B cell malignancies (1)
- B cell precursor acute lymphoblastic leukemia (1)
- B cell receptor (1)
- B cell subpopulations (1)
- B-cell antigen receptor (1)
- B-cell immunology (1)
- B-cell non-Hodgkin lymphoma (1)
- B-cell receptor (1)
- B16 cells (1)
- BAG3 (1)
- BATF3 (1)
- BBB (1)
- BCL-2 (1)
- BCL11b (1)
- BCR signaling (1)
- BCR-ABL (1)
- BCX7353 (1)
- BFIS (1)
- BG-index (1)
- BI1361849 (1)
- BIAM switch assay (1)
- BIAM-switch (1)
- BIRC5 (1)
- BK channel (1)
- BMAC (1)
- BMI (1)
- BMSC (1)
- BNC2 (1)
- BPD (1)
- BPDCN (1)
- BRAF V600E (1)
- BRAF inhibitors (1)
- BRAF mutation (1)
- BRD4-NUT (1)
- BRUCE (1)
- BRVO (1)
- BTC (1)
- BTK (1)
- BV6 (1)
- Babesia venatorum (1)
- Back pain (1)
- Backpropagating action potential (1)
- Bacterial meningitis (1)
- Bacterial pathogenesis (1)
- Bacterial pathogens (1)
- BadA, (1)
- Bag6 (1)
- Ballet (1)
- Bariatric surgery (1)
- Barlow disease (1)
- Bartonella (1)
- Basal Ganglia (1)
- Basel Consensus Statement (1)
- Basler Consensus Statement (1)
- Bathyergidae (1)
- Batten disease (1)
- Bayesian (1)
- Bayesian inference (1)
- Bayesian model (1)
- Bcl-2 (1)
- Bcr-Abl (1)
- Becton Dickinson (1)
- Bee venom allergy (1)
- Behavior (1)
- Behavioral analysis (1)
- Benchmarks (1)
- Benign disorder (1)
- Benign pulmonary diseases (1)
- Benigne Lungenerkrankungen (1)
- Beratung (1)
- Berci needle (1)
- Best practice (1)
- Best-practice model (1)
- Bestimmungsmethoden (1)
- Bevacizumab (1)
- Bewegungsanalyse mit Inertialsensoren (1)
- Bias (1)
- Bibliometric analysis (1)
- Bibliometrics (1)
- Bidirectional genes (1)
- Big Five (1)
- Big data (1)
- Big five (1)
- Biglycan (1)
- Bilateral cochlear implant (1)
- Bildung (1)
- Biliary physiology (1)
- Biliary tree (1)
- Biliary tree stones (1)
- Bilirubin (1)
- Bioactivity-guided fractionation (1)
- Bioavailability prediction (1)
- Biofilm (1)
- Biofluids (1)
- Biological (1)
- Biological Activity (1)
- Biological heart valves (1)
- Biological invasion (1)
- Biological markers (1)
- Biomarkers & Diagnostic Imaging (1)
- Biomechanical analysis (1)
- Biophysical models (1)
- Bioprosthesis (1)
- Biotechnology (1)
- Bipolar (1)
- Birth weight (1)
- Bisphosphonates (1)
- Blended learning curriculum · (1)
- Blended-Learning-Curriculum (1)
- Blended-learning (1)
- Blog (1)
- Blood cells (1)
- Blood loss (1)
- Blood plasma (1)
- Blood transfusion (1)
- Bloodstream infection (1)
- Bloodstream infections (1)
- Blow fly (1)
- Blowflies (1)
- BluePrint (1)
- Blurred vision (1)
- Body limbs (1)
- Body-contouring surgery (1)
- Bologna process (1)
- Bologna-Prozess (1)
- Bone and joint mechanics (1)
- Bone cancer (1)
- Bone marrow aspirate concentrate (1)
- Bone marrow aspiration (1)
- Bone marrow cells (1)
- Bone marrow fibrosis (1)
- Bone marrow mononuclear cells (1)
- Bone metastasis (1)
- Bone strength assessment (1)
- Borrelia Garinii (1)
- Borrelia burgdorferi (1)
- Borrelia miyamotoi (1)
- Bortezomib (1)
- Bottom-up (1)
- Bradykinin (1)
- Brain (1)
- Brain anatomy (1)
- Brain damage (1)
- Brain development (1)
- Brain injury (1)
- Brain ischemia (1)
- Brain repair (1)
- Brain tumors (1)
- BrainNet Europe consortium (1)
- Breast neoplasm (1)
- Breast reconstruction (1)
- Breathing (1)
- Breech delivery (1)
- Bright light therapy (1)
- Brij 35 (1)
- BrijL23 (1)
- Brms (1)
- Bronchial inflammation (1)
- Bronchitis severity scale (1)
- Bronchodilator agents (1)
- Bronchopulmonary dysplasia (1)
- Bufonidae (1)
- Bungarus niger (1)
- Burst (1)
- Bypass liner (1)
- C-clamp (1)
- C-reactive proteins (1)
- C1 esterase inhibitor (human) (1)
- C1-INH (C1 inhibitor, C1-esterase inhibitor) (1)
- C1-esterase inhibitor protein (1)
- C1-inhibitor (1)
- C1-inhibitor deficiency (1)
- C2 domain (1)
- C3M (1)
- C4M (1)
- C5 acylcarnitine (1)
- C57BL/6J mice (1)
- C57BL/6N mice (1)
- C6 ceramide (1)
- CA (1)
- CA1 (1)
- CAKUT (1)
- CAM (1)
- CAR-NK cell (1)
- CAR-T cell (1)
- CAT (1)
- CCL2 (1)
- CCN2 (1)
- CD137 (1)
- CD16 (1)
- CD23 (1)
- CD271 (1)
- CD3 (1)
- CD3/19 depletion (1)
- CD3/CD19 depletion (1)
- CD34 (1)
- CD34 selection (1)
- CD4 binding site (1)
- CD41 (1)
- CD44 (1)
- CD45RA naïve lymphocytes (1)
- CD49d (1)
- CD56 (1)
- CD62P (1)
- CD74 (1)
- CD8 (1)
- CD8+ T cell (1)
- CD8+ T lymphocytes (1)
- CD8+ T-cell mediated tumor suppression (1)
- CD8+ tumor infiltrating lymphocytes (1)
- CD95/Fas receptor (1)
- CDK inhibitor (1)
- CDK4/6 inhibitor (1)
- CDK4/CDK6 (1)
- CDK9 (1)
- CDKN2A (1)
- CEBPE (1)
- CGD (1)
- CGN codon (1)
- CHA2DS2-VASc-score (1)
- CHIP (1)
- CHRNA10 (1)
- CHRNA7 (1)
- CHRNA9 (1)
- CIK cell (1)
- CIOMS (1)
- CLEC-2 (1)
- CMS (1)
- CMVepidemiology (1)
- CNS (1)
- CNS cancer (1)
- CNS toxicity (1)
- CNVs (1)
- CO2-induced forced ventilation (1)
- COBAS Taqman (1)
- COI (1)
- COII (1)
- COMT (1)
- COPD course and therapy (1)
- CPT1A (1)
- CRE-dependent transcription (1)
- CRE-luciferase (1)
- CREB inhibitor (1)
- CRISPR/Cas (1)
- CRISPR/dCas9 (1)
- CRM (1)
- CRM1 (1)
- CRP (1)
- CRT-D (1)
- CRVO (1)
- CSC marker (1)
- CT pulmonary angiography (1)
- CT radiation exposure (1)
- CT-guidance (1)
- CT-guided interventions (1)
- CTLA-4 (1)
- CTX (1)
- CUELA system (1)
- CUP (1)
- CVD biomarker (1)
- CVID (1)
- CWS Studiengruppe (1)
- CXCL10 (1)
- CXCL16 (1)
- CY-503 (1)
- CYBA/p22phox (1)
- CYP1A1 (1)
- Ca2+ imaging (1)
- Caco 2 cells/metabolism (1)
- Caco-2 cells (1)
- Caco‐2 cells (1)
- Caffeine (1)
- Calcium signalling (1)
- Calliphoridae (1)
- Calnexin (1)
- Canada (1)
- Cancer Staging (1)
- Cancer detection (1)
- Cancer epigenetics (1)
- Cancer of unknown primary (1)
- Cancer risk factors (1)
- Cancer staging (1)
- Cancer stem cells (1)
- Cancer therapeutic resistance (1)
- Candida spp (1)
- Carbapenem-resistente Gram-negative Bakterien (CRGN) (1)
- Carbapenemasen (1)
- Carbohydrates (1)
- Carbon tetrachloride (1)
- Carcinoma, Ductal, Breast (1)
- Cardiac (1)
- Cardiac Fibrosis (1)
- Cardiac acoustic biomarkers (1)
- Cardiac device therapy (1)
- Cardiac fibroblast (1)
- Cardiac function (1)
- Cardiac masses (1)
- Cardiac monitoring (1)
- Cardiac necroenzymes (1)
- Cardiac output (1)
- Cardiac remodelling (1)
- Cardiac surgery patients (1)
- Cardiac troponin (1)
- CardioMEMS™ HF system (1)
- Cardiogenic shock (1)
- Cardiomyocyte signaling pathways (1)
- Cardiomyopathy (1)
- Cardiopulmonary bypass (1)
- Cardiovascular Magnetic Resonance (CMR) (1)
- Cardiovascular biology (1)
- Cardiovascular epidemiology (1)
- Cardiovascular genetics (1)
- Cardiovascular mortality (1)
- Career promotion (1)
- Careers (1)
- Carrier-bound fibrin sealant (1)
- Cas9 inhibitor (1)
- Case management [MeSH] (1)
- Case report (1)
- Castleman’s disease (1)
- Catch-up validation study (1)
- Causality (1)
- Cause of death (1)
- Cdk1/cyclin B1 (1)
- Cell Adhesion (1)
- Cell adhesion (1)
- Cell cortex (1)
- Cell cultures (1)
- Cell cycle (1)
- Cell distribution (1)
- Cell division (1)
- Cell membranes (1)
- Cell metabolism (1)
- Cell motility (1)
- Cell plasticity (1)
- Cell processing (1)
- Cell-assisted lipotransfer (1)
- Cell-based therapies (1)
- Cell-to-Cell Spread (1)
- Cellular (1)
- Cellular imaging (1)
- Cellular inflammatory response (1)
- Cellular neuroscience (1)
- Cellular stress (1)
- Cellular stress responses (1)
- Cementation (1)
- Center-specific time in therapeutic range (cTTR) (1)
- Central nervous system (1)
- Central nervous system metastases (1)
- Centrifugation (1)
- Ceramic (1)
- Cerasorb (1)
- Cerclage (1)
- Cerebellar ataxia (1)
- Cerebellum (1)
- Cerebral Vasospasm (1)
- Cerebral cortex (1)
- Cerebral ischemia (1)
- Cerebral toxoplasmosis HIV (1)
- Cerebral vasospasm (1)
- Cerebrovascular (1)
- Certification (1)
- Cervical (1)
- Cesarean delivery (1)
- Change Management (1)
- Checkpoint kinase (1)
- Checkpoints (1)
- Chemical company (1)
- Chemical ecology (1)
- Chemical modification (1)
- Chemiluminescence (1)
- Chemobrain (1)
- Chemoembolization (1)
- Chemokine CCL2 (1)
- Chemokines (1)
- Chemoradiation (1)
- Chemorefractory advanced gastric cancer (1)
- Chemosensitivity (1)
- Chest pain unit (1)
- Chikungunya virus (1)
- Child (1)
- Child adiposity (1)
- Children and adolescents (1)
- Chimerism (1)
- Chlorides (1)
- Chloroform (1)
- Cholecystectomy (1)
- Cholesterin (1)
- Cholesterol (1)
- Chondral Lesion (1)
- Chondrocyte (1)
- Chondrocyte signalling (1)
- Chondrocytes (1)
- Chorion (1)
- Chromatin and Epigenetics (1)
- Chromatin conformation (1)
- Chromoendoscopy (1)
- Chromosomal deletion (1)
- Chromosomale Translokation (1)
- Chronic Hepatitis C (1)
- Chronic ankle instability (1)
- Chronic care model (1)
- Chronic conditions (1)
- Chronic depression (1)
- Chronic disease [MeSH] (1)
- Chronic health condition (1)
- Chronic heart failure (1)
- Chronic hepatitis C virus (1)
- Chronic illness (1)
- Chronic infection (1)
- Chronic inflammation (1)
- Chronic intestinal failure (1)
- Chronic medical conditions (1)
- Chronic obstructive airway disease (1)
- Chronic pancreatitis (1)
- Chronic periodontiti (1)
- Chronification (1)
- Chronology of disease (1)
- Cigarettes (1)
- Cinnarizine (1)
- Cinryze® (1)
- Circadian rhythms and sleep (1)
- Circulation (1)
- Cirugía (1)
- Citation (1)
- Citationrate (1)
- Cities (1)
- Classification (1)
- Claudin 5 (1)
- Cleanliness level (1)
- Cleft palate (1)
- Clincial pharmacology (1)
- CliniMACS (1)
- Clinical Global Impression of Change (1)
- Clinical Skills (1)
- Clinical Trials and Observations (1)
- Clinical effectiveness (1)
- Clinical frailty scale (1)
- Clinical outcome (1)
- Clinical pathways (1)
- Clinical psychometry (1)
- Clinical skills (1)
- Clinical variation (1)
- Cln3 (1)
- Clonidine (1)
- Clostridioides difficile (1)
- Clostridium (1)
- Closure (1)
- Cluster (1)
- Cluster randomization (1)
- Clustering (1)
- Co-culture (1)
- Co-morbidity (1)
- Coagulopathy management (1)
- Coexistence (1)
- Cofilin (1)
- Cognitive neurology (1)
- Cognitive psychology (1)
- Cohort Analysis (1)
- Cohort study (1)
- Colchicum (1)
- Cold pain (1)
- Colitis Ulcerosa (1)
- Collagen antibody-induced arthritis (1)
- Collagen hemostat (1)
- Collagen type I (1)
- Collagen type III (1)
- Collagens (1)
- Colloids (1)
- Colon cancer (1)
- Colon capsule endoscopy (1)
- Colonisation (1)
- Combined immune checkpoint blockade (1)
- Combo® DTS (1)
- Communicable diseases (1)
- Community health services (1)
- Comorbidities (1)
- Comorbidity (1)
- Comparative effectiveness research (1)
- Comparative study (1)
- Comparators (1)
- Compartmental modeling (1)
- Competencies (1)
- Complement Regulator (1)
- Complement cascade (1)
- Complement system (1)
- Complementary medicine (1)
- Complementation rate (1)
- Complete heart block (1)
- Complex II (1)
- Complex hernia (1)
- Complex networks (1)
- Complexin 1 (1)
- Complexin-1 (1)
- Complexome profiling (1)
- Complication (1)
- Comprehensive cancer centers (1)
- Computational biology and bioinformatics (1)
- Computational model (1)
- Computed axial tomography (1)
- Computed tomography pulmonary angiography (CTPA) (1)
- Computer hardware (1)
- Computer science (1)
- Computer simulation (1)
- Computer software (1)
- Computer-aided drug design (1)
- Computers (1)
- Concept paper (1)
- Conception (1)
- Concurrent chemoradiotherapy (1)
- Conditional gene trap (1)
- Conduct problems (1)
- Conduit function (1)
- Confocal endomicroscopy (1)
- Conformational change (1)
- Congenital CMVinfection (1)
- Congenital anomalies (1)
- Congenital duodenal obstruction (1)
- Congenital ocular motor apraxia (1)
- Coniosporium corticale (1)
- Consciousness (1)
- Consensus methods (1)
- Conservative (1)
- Consortia (1)
- Constrained posture (1)
- Contact precautions (1)
- Contractile function (1)
- Contrast-Enhancing Lesions (1)
- Contrast-enhanced (1)
- Conventional Chemotherapeutic (1)
- Conventional synthetic disease-modifying antirheumatic drug (1)
- Coping (1)
- Copy number variation (1)
- Cord blood transplantation (1)
- Core needle biopsy (1)
- Cornea (1)
- Coronary artery disease (1)
- Coronary artery disease (CAD) (1)
- Coronary intervention (1)
- Cost-effectiveness (1)
- Cost-effectiveness analysis (1)
- Couch tracking (1)
- Council for International Organizations of Medical Sciences (1)
- CoxVa (1)
- Coxibs (1)
- Craniomandibular disorders (1)
- Credentialing (1)
- Creeping Disease (1)
- Crispr/Cas (1)
- Critical Online Reasoning Assessment (1)
- Critical bleeding (1)
- Critical care (1)
- Critical care and emergency medicine (1)
- Critical haematocrit (1)
- Critical pathway (1)
- Cross-contamination (1)
- Cross-sectional (1)
- Cross-sectional study (1)
- Crosscorrelation (1)
- Crossmodal (1)
- Cryo-electron microscopy (1)
- Cryoablation (1)
- Cryoballoon (1)
- Cryptococcus (1)
- Cryptostroma corticale (1)
- CspA (1)
- Cumulative dose (1)
- Cure (1)
- Curriculum (1)
- Curvilinear dose response (1)
- CyberKnife (1)
- Cyp46a1 (1)
- CysLTR1 (1)
- Cysteine‐Rich Domain (CRD) (1)
- Cystic fibrosis (1)
- Cytokine (1)
- Cytology (1)
- Cytomegalovirus (CMV) (1)
- Cytoplasm (1)
- Cytoplasmic staining (1)
- Cytotoxic CD8+ T cell (1)
- C‐reactive protein (1)
- D-dimer (1)
- D2-autoreceptor (1)
- DAMP (1)
- DAMPs (1)
- DBH genotype (1)
- DCM (1)
- DDA (1)
- DDIT4 (1)
- DEE (1)
- DFNB9 (1)
- DHA (1)
- DILI database case quality (1)
- DKK1 (1)
- DKTK-ROG (1)
- DLBCL (1)
- DMARDs (synthetic) (1)
- DME (1)
- DMXAA (1)
- DNA Damage (1)
- DNA double-strand break repair (1)
- DNA repair (1)
- DNA replication (1)
- DNA sequence analysis (1)
- DNA sequencing (1)
- DNA-binding proteins (1)
- DNA-protein crosslinks (1)
- DOK1 (1)
- DR5 (1)
- DSAEK (1)
- DSS /AOM (1)
- DTHR (1)
- DUBs (1)
- DYRK1A (1)
- DYT1 (1)
- Dabigatran (1)
- Dancer (1)
- Darmerkrankung (1)
- Darreichungsform (1)
- Darunavir (1)
- Data acquisition (1)
- Data mining (1)
- Data monitoring (1)
- Data protection (1)
- Data validation (1)
- Database (1)
- Database searching (1)
- Databases (1)
- Dataset bias (1)
- Datenqualität (1)
- Datenschutz (1)
- David technique (1)
- Decision impact (1)
- Decision-making (1)
- Decolonization (1)
- Deep brain stimulation (1)
- Deficient Inhibition (1)
- Deformation (1)
- Delayed Cerebral Ischemia (1)
- Delayed union (1)
- Deletion mutation (1)
- Delivery mode (1)
- Delivery quality assurance (1)
- Delphi Survey (1)
- Delphie-Befragung (1)
- Dementia (1)
- Dendritic cell (1)
- Dendritic cell population (1)
- Dendritic cells (1)
- Dendritic spines (1)
- Denervation (1)
- Dengue (1)
- Dengue fever (1)
- Dengue virus (1)
- Denguefieber (1)
- Density equalizing (1)
- Density-equalizing mapping (1)
- Dental implants (1)
- Dental phobia (1)
- Dental training (1)
- Dentition (1)
- Depolarization (1)
- Dermal fat (1)
- Dermatomyositis (1)
- Desinfektion von Flugzeugen (1)
- Desmin (1)
- Determination method (1)
- Developmental disorders (1)
- Devic disease (1)
- Devic syndrome (1)
- Diabetic nephropathy (1)
- Diagnostic differentiation (1)
- Diagnostic techniques and procedures (1)
- Diagnostic test (1)
- Diagnostik von MLL Translokationen (1)
- Diary Data (1)
- Dicer (1)
- Dichloromethane (1)
- Didaktik (1)
- Diesel (1)
- Dietary intake (1)
- Differential expression (1)
- Diffuse astrocytoma (1)
- Diffuse large B cell lymphoma (1)
- Diffusion of Innovations (1)
- Digenic model (1)
- Digestive system (1)
- Digital breast tomosynthesis (DBT) (1)
- Digital ethics (1)
- Digital hybrid visualization (1)
- Digital mammography (1)
- Digital rectal examination (1)
- Digital transformation (1)
- Digitale Ethik (1)
- Digitale Transformation (1)
- Digitalisierung (1)
- Digitalization (1)
- Dilated cardiomyopathy (1)
- Dimer (1)
- Dimers (Chemical physics) (1)
- Dipeptide (1)
- Diphosphonates (1)
- Direct Acting Antivirals (DAA) (1)
- Direct acting antiviral therapies (1)
- Direct-acting antiviral agents (DAAs) (1)
- Disabilities (1)
- Disabling back pain (1)
- Disc herniation (1)
- Discs large (1)
- Disease burden (1)
- Disease management (1)
- Diseases (1)
- Disinfection of aircraft (1)
- Disintegration (1)
- Dissemination (1)
- Dissociative seizures (1)
- Distance to water (1)
- Distress (1)
- Distress screening (1)
- Distribution (1)
- Dog (1)
- Dogs (1)
- Domestic (1)
- Donor Selection (1)
- Dorsolateral prefrontal cortex (1)
- Dose optimization (1)
- Doubling time (1)
- Down's syndrome (1)
- Doxorubicin (1)
- Drug (1)
- Drug Discovery (1)
- Drug Therapy (1)
- Drug discovery (1)
- Drug hepatotoxicity (1)
- Drug induced liver injury (1)
- Drug interactions (1)
- Drug permeability (1)
- Drug resistance/synergy (1)
- Drug screens (1)
- Drug targeting (1)
- Dual energy CT (1)
- Dual therapy (1)
- Dual-Source CT (1)
- Duchenne’s muscular dystrophy (1)
- Dumon stents (1)
- Duodenal atresia (1)
- Duodenal stenosis (1)
- Dvc1 (1)
- E protein structure (1)
- E-cadherin (1)
- E-cadhérine (1)
- E-learning (1)
- E. coli (1)
- E/I-Balance (1)
- E3-Ligases (1)
- EBM (1)
- ECLS (1)
- ECM (1)
- EDB (1)
- EDTA-plasma (1)
- EEG reference choices (1)
- EFP1 (1)
- EGF (1)
- EGFL7 (1)
- EGFP (1)
- EGFR inhibitor (1)
- EGFR pathway (1)
- EGR1-dependent transcription (1)
- EIIIB (1)
- ELISA (1)
- ELSID-Diabetes (1)
- EMD 55900 (1)
- EMD 72000 (1)
- EMT (1)
- EPA (1)
- EQ (1)
- EQIP (1)
- ER stress (1)
- ERBB2 (1)
- ERBB2 (HER2/neu) (1)
- ERK3/MAPK6 (1)
- ERM (1)
- ERMS (1)
- ERP (1)
- ERSCongress (1)
- ES (1)
- ES cells (1)
- ESBL (1)
- ESMO-MCBS (1)
- ET (1)
- ETP-ALL (1)
- ETS (1)
- EWS/Fli1 (1)
- EZ-IO® needle driver (1)
- Early Rheumatoid Arthritis (1)
- Early diagnosis (1)
- Early goal-directed therapy (1)
- Early intervention (1)
- Early recurrence (1)
- Ebola virus (1)
- Echocardiography (1)
- Echovirus-30 (1)
- Eclampsia (1)
- Ecological momentary assessment (1)
- Economic analysis (1)
- Economic benchmarks (1)
- Economic evaluation (1)
- Economic impact (1)
- Economics (1)
- Ectopic bone formation (1)
- Edentulous jaw (1)
- Edoxaban (1)
- Educación médica (1)
- Efavirenz (1)
- Effective connectivity (1)
- Effectivity (1)
- Efficacy (1)
- Eicosanoids (1)
- Eignungsprüfung (1)
- Einfachauswahlverfahren (1)
- Eingangstest (1)
- Einreibetechnik (1)
- Elastogenesis (1)
- Elderly patients (1)
- Elective caesarean section (1)
- Electrical accident (1)
- Electrical instability (1)
- Electrical stimulation (1)
- Electroencephalography – EEG (1)
- Electrolytes (1)
- Electron transport chain (1)
- Electronic cigarettes (1)
- Electrophysiology (1)
- Electrotonic analysis (1)
- Elektroenzephalographie (1)
- Elektronenmikroskopie (1)
- Elevation (1)
- Elimination (1)
- Ellipsoids (1)
- Embolization (1)
- Embryos (1)
- Emergency (1)
- Emergency medicine (1)
- Emotion (1)
- Emotion processing (1)
- Emotional recognition (1)
- Empathy (1)
- Empfehlungen (1)
- Emphysema (1)
- Employment (1)
- Employment effect (1)
- End-of-life decisions (1)
- Endocrine cancer (1)
- Endometrial cancer (1)
- Endometriosis (1)
- Endoplasmic reticulum (1)
- Endoscopic coronary revascularisation (1)
- Endoscopic retrograde Cholangiopancreatography (ERCP) (1)
- Endoscopic ultrasound (1)
- Endoskopik koroner revaskülarizasyon (1)
- Endosomes (1)
- Endothelial cell (EC) (1)
- Endothelial nitric oxide synthase (1)
- Endothelium (1)
- Endotoxins (1)
- Endovascular repair (1)
- Endovaskuläre Behandlung (1)
- Endpoints (1)
- Enfermedades crónicas (1)
- England (1)
- Enteral nutrition (1)
- Enteric nervous system (1)
- Enterobacteriaceae (1)
- Enterostomy (1)
- Enterostomy closure (1)
- Enterostomy formation (1)
- Entfernung (1)
- Entorhinal cortex lesion (1)
- Entrenamiento práctico (1)
- Entzündung (1)
- EnvZ signalling (1)
- Envenomation (1)
- Environmental chemistry (1)
- Enzyme kinetics (1)
- Enzyme mechanisms (1)
- Enzyme regulation (1)
- Epidemiological data (1)
- Epidermolysis bullosa simplex with muscular dystrophy (1)
- Epidural block (1)
- Epilepsie (1)
- Epileptic seizures (1)
- Epileptische Anfälle (1)
- Epithelial cells (1)
- Epstein–Barr virus (1)
- Equipment (1)
- Equity (1)
- Eradication (1)
- Ergonomic analysis (1)
- Ergonomie am Arbeitsplatz (1)
- Ergonomische Analyse (1)
- Erythema migrans (1)
- Erythrocytes (1)
- Erythropoiesis (1)
- Esophageal adenocarcinoma (1)
- Esophageal adenocarcinoma (EAC) (1)
- Esophagectomy (1)
- Esophagogastric (1)
- Estradiol (1)
- Estrogen Receptor Modulators (1)
- Ethnicity (1)
- European Society for Immunodeficiencies (ESID) (1)
- European babesiosis (1)
- European registry for idiopathic pulmonary fibrosis (eurIPFreg) (1)
- Evaluation in microsurgery (1)
- Evaluationspraxis (1)
- Everolimus resistance (1)
- Evidence based medicine (1)
- Evidence-based dentistry (1)
- Evidence-based guidelines (1)
- Evidenzbasierte Medizin (1)
- Evolutionary biology (1)
- Exacerbations (1)
- Examination questions (1)
- Excitability (1)
- Exercise challenge at an ambient temperature (1)
- Exercise challenge in a cold chamber (1)
- Exercise testing (1)
- Exercise therapy (1)
- Exercise-induced bronchoconstriction (1)
- Exosomes (1)
- Experimental autoimmune encephalomyelitis (1)
- Experts (1)
- Expression (1)
- Extended Glasgow outcome scale (eGOS) (1)
- Extension study (1)
- External-/self-assessment (1)
- Extinction (1)
- Extracellular RNA (1)
- Extracellular RNA (eRNA) (1)
- Extracellular matrix proteins (1)
- Extracellular signal-regulated kinase 1/2 (1)
- Extracellular vesicles (1)
- Extracorporeal circulation (1)
- Extracorporeal life support (1)
- Extracorporeal purification (1)
- Extreme hypo-fractionation (1)
- F508del homozygous (1)
- FAAM (1)
- FAIR (1)
- FAK (1)
- FAM134B (1)
- FAV00A (1)
- FEV1 (1)
- FFLU (1)
- FFPE (1)
- FGFR (1)
- FIB-4 (1)
- FIV (1)
- FLT3 (1)
- FOLFIRI (1)
- FOXO3a (1)
- FREEDOM (1)
- FSS (1)
- FX06 (1)
- Facet joint osteoarthritis (1)
- Factor H (1)
- Factor analysis (1)
- Faculty Development (1)
- Falciparum (1)
- Fallbeispiele (1)
- Family Physician (1)
- Fascia (1)
- Fast-track (1)
- Fat layer (1)
- Fatty acids (1)
- Fbw7 (1)
- Fc receptor (1)
- Fear conditioning (1)
- Feasibility (1)
- Feature tracking (1)
- Feedback (1)
- Feedback loop (1)
- Feline bartonellosis (1)
- FemNAT-CD (1)
- Female (1)
- Female adolescents (1)
- Females (1)
- Feminismus (1)
- Femoral neck (1)
- Fertigkeiten (1)
- Fertilität (1)
- Fertilité (1)
- Fetal bovine serum (1)
- Fever (1)
- Fevers (1)
- Fibrinolytic (1)
- Fibroblast growth factor (1)
- Fibronectin (1)
- Fibrotest (1)
- Fibulin-4 (1)
- Fibulin-5 (1)
- Filovirus cell entry; attachment factors redundancy; SH-SY5Y cell line; host–pathogen interactions (1)
- Finanzierung (1)
- Finite Element Method (1)
- First experience with patients (1)
- First site of metastatic disease (1)
- First-line combination antiretroviral therapy (1)
- First-line regimen (1)
- Five-Konzept (1)
- Fleas (1)
- FlexTouch (1)
- Flexibility (1)
- Flexible Endoscopic Evaluation of Swallowing (1)
- Fluorescence imaging (1)
- Fluorescence-in-situ-hybridization (FISH) (1)
- Fluorescent Probes (1)
- Foam rolling (1)
- Folic acid (1)
- Follow-up (1)
- Food effects (1)
- Foramen ovale (1)
- Forensics (1)
- Forkhead box (1)
- Formation dance (1)
- Foxp1 (1)
- Fracture risk (1)
- Francisella tularensis (1)
- Francisella tularensis subspecies holarctica (1)
- Frankfurt <Main> / Klinikum (1)
- Frankfurt microsurgery course (1)
- Fresh frozen plasma (1)
- Frontotemporal dementia (1)
- Frühgeborenes (1)
- Fuchs endothelial dystrophy (1)
- Fuctional connectivity (1)
- Functional ankle instability (1)
- Functional capacity (1)
- Functional characterization (1)
- Functional connectivity (1)
- Functional electrical stimulation (1)
- Functional mitral regurgitation (1)
- Functional outcome (1)
- Functionally-impaired elderly (1)
- FungiScope® registry (1)
- Fusarium (1)
- Fusion Proteins, BCR-ABL (1)
- G-protein (1)
- G-protein-coupled receptors (1)
- G/P (1)
- G2A (1)
- G3BP (1)
- G9a/EHMT2/KMT1C (1)
- GABA (1)
- GABAergic interneurons (1)
- GHQ-28 (1)
- GLI inhibitors (1)
- GLUT1 (1)
- GM-CSF (1)
- GPCR (1)
- GPVI (1)
- GRADE (1)
- GRK2 (1)
- GRX1-roGFP2 (1)
- GSK2334470 (1)
- GSK3α (1)
- GSK3β (1)
- GVHD (1)
- GVL (1)
- Gaba (1)
- Gadopentate dimeglumine (1)
- Gads (1)
- Gait analysis (1)
- Gallbladder percutaneous drainage (1)
- Galleria mellonella (1)
- Games (1)
- Gamma-Band Activity (1)
- Gamma-aminobutyric acid (1)
- Gap junctions (1)
- Gas gangrene (1)
- Gastritis (1)
- Gastroesophageal reflux disease (1)
- Gastroesophageal reflux disease symptoms (1)
- Gastrointestinal bleeding (1)
- Gastrointestinal cancer (1)
- Gastrointestinal neoplasm (1)
- Gastrointestinal tract (1)
- Gaucher disease type III (1)
- Gaucher’s disease (1)
- Gebärmutterhalskrebs (1)
- Gemcitabine (1)
- Gender analysis (1)
- Gender equality (1)
- Gender gap (1)
- Gender reassigning surgery (1)
- Gene Regulation (1)
- Gene engineering (1)
- Gene expression prediction (1)
- Gene fusion (1)
- Gene microarray analysis (1)
- Gene ontology (1)
- Gene polymorphism (1)
- Gene prediction (1)
- Gene set analysis (1)
- Gene-protein assay (1)
- GeneMANIA (1)
- General clinical cardiology (1)
- General dental practice (1)
- General practice/family medicine (1)
- General practitioner (1)
- Generation Y (1)
- Generation time (1)
- Generic drugs (1)
- Genetic causes of cancer (1)
- Genome annotation (1)
- Genomic instability (1)
- Geographically weighted regression (GWR) (1)
- German (1)
- German PID-NET registry (1)
- Gesprächsführung (1)
- Gestational age (1)
- Gestational diabetes (1)
- Gesundheitsamt (1)
- Gezielte Therapie (1)
- Giant lymph node hyperplasia (1)
- Gift (1)
- Gimbaled tracking (1)
- Glaucoma (1)
- Gleason Score (1)
- Gleason upgrading (1)
- Glioma (1)
- Glivec® (1)
- Global protein synthesis rates (1)
- Glomerular Filtration Rate (1)
- Glomerular diseases (1)
- Glomerulonephritis (1)
- Glucocorticoids (1)
- Glucose Transporter Type 1 (1)
- Glycogen synthase kinase 3 beta (1)
- Glycolysis (1)
- Glycosphingolipids (1)
- Glyoxalase I (1)
- Goal-oriented care (1)
- Gold (1)
- Goserelin (1)
- Grado en medicina (1)
- Graft function (1)
- Graft survival (1)
- Gram negative bacteria (1)
- Gram-positive infection (1)
- Granule cell (1)
- Grass pollen (1)
- Greater tuberosity fractures (1)
- Gross tumor volume optimization (1)
- Growth cone (1)
- Growth factor (1)
- Growth factor signalling (1)
- Guided surgery (1)
- Guided tissue regeneration (1)
- Guideline (1)
- Guideline adherence (1)
- Gut-liver-axis (1)
- GvHD (1)
- Gαq/11 (1)
- H-Index (1)
- H1N1 (1)
- H3 receptor (1)
- H5N1 (1)
- HACA (1)
- HAEGARDA (1)
- HAI‐1 (1)
- HBV filaments (1)
- HBV genotypes (1)
- HBV reactivation (1)
- HBV surface protein (1)
- HCC recurrence (1)
- HCMV (1)
- HCV treatment (1)
- HDAC-inhibition (1)
- HER2 c-erbB2 (1)
- HER2-positive (1)
- HER2/neu (ERBB2) (1)
- HEV (1)
- HFrEF (1)
- HGF (1)
- HH (1)
- HIBCPP cells (1)
- HIF (1)
- HIF1α (1)
- HIFU (1)
- HILI (1)
- HIV protease inhibitors (1)
- HIV serodiagnosis (1)
- HIV therapy (1)
- HIV-1 escape restriction (1)
- HIV-RNA (1)
- HLA DQ haplotypes (1)
- HLA class I loss (1)
- HLA class II (1)
- HLA peptidome (1)
- HMA (1)
- HMGB1 (1)
- HODE (1)
- HRM (1)
- HRas (1)
- HSPC (1)
- HSV-1 (1)
- HSV-2 (1)
- HUVEC (1)
- Haematoma expansion (1)
- Haematopoietic stem cells (1)
- Haemodynamic monitoring (1)
- Haemostatics (1)
- Hand-foot syndrome (1)
- Haploidentical stem cell transplantation (1)
- Haplotypes (1)
- Hard-to-reach population (1)
- Hashimoto’s thyroiditis (1)
- Hausarztmangel (1)
- HbA1c (1)
- Head and neck Cancer (1)
- Head injury (1)
- Health Policy (1)
- Health Systems (1)
- Health care (1)
- Health care access (1)
- Health care resource utilization (1)
- Health care sector (1)
- Health care workers (1)
- Health education and awareness (1)
- Health information (1)
- Health literacy (1)
- Health policy (1)
- Health risk analysis (1)
- Health services (1)
- Health services research [MeSH] (1)
- Health-related quality of life (1)
- Health-seeking behaviour (1)
- Health‐related quality of life (1)
- Heart regeneration (1)
- Heat dissipation (1)
- Heat pain (1)
- Hebbian plasticity (1)
- Hedgehog (1)
- Hedgehog pathway (1)
- Helpline (1)
- Hemagglutination inhibition assay (1)
- Hematocrit value (1)
- Hematopoietic stem and progenitor cells (HSPCs) (1)
- Hematopoietic stem cell transplantation (1)
- Hematopoietic stem cells (1)
- Hematoxylin staining (1)
- Hemodilution (1)
- Hemodynamic management (1)
- Hemodynamics (1)
- Hemoglobin (1)
- Hemophilia A (1)
- Hemorrhagic shock (1)
- Hemostasis (1)
- Hemostatics (1)
- HepaRG cells (1)
- Hepatic encephalopathy (1)
- Hepatitis (1)
- Hepatitis B (1)
- Hepatitis B infection (1)
- Hepatitis B vaccination (1)
- Hepatitis B virus (1)
- Hepatitis C (1)
- Hepatitis C, Chronic (1)
- Hepatitis c (1)
- Hepatotoxicity (1)
- Herbal hepatotoxicity (1)
- Herbalife (1)
- Herbs (1)
- Herd immunity (1)
- Hereditary breast and ovarian cancer (1)
- Hereditary breast cancer (1)
- Hereditary ovarian cancer (1)
- Heregulin (1)
- Hernia recurrence (1)
- Hernia surgery (1)
- Heterogeneity (1)
- Hexavalent vaccine (1)
- HhAntag (1)
- HiC (1)
- HiChIP (1)
- Hif-1 alpha (1)
- Hif1α (1)
- High-dose chemotherapy (1)
- High-income countries (1)
- High-intensity interval endurance training (1)
- High-risk cardiac surgery (1)
- High-risk patient (1)
- High-throughput screening (1)
- Highly infectious diseases (1)
- Hindu Kush Himalayas (1)
- Hip (1)
- Hippo signaling (1)
- Hippocampal volume (1)
- Hirnverletzung (1)
- Hispanic people (1)
- Histone post-translational modifications (1)
- Histoplasma qPCR (1)
- Hmox1 (1)
- Hochansteckende Krankheiten (1)
- Hochschuldidaktik (1)
- Hodgkin’s lymphoma (1)
- Homeostatic plasticity (1)
- Homicide (1)
- Homocysteine (1)
- Hormone de régression müllérienne (1)
- Horner's syndrome (1)
- Horses (1)
- Hospital (1)
- Hospitalization (1)
- Hospitalizations (1)
- Host-directed therapies (1)
- Host-targeting agents (HTAs) (1)
- House dust mite allergy (1)
- Household contacts (1)
- Hrvaška (1)
- Hsp70 (1)
- Hsp90 inhibitor (1)
- HuR (1)
- Huh7 (1)
- Human (1)
- Human experimental pain models (1)
- Human immunodeficiency virus (HIV) (1)
- Human olfaction (1)
- Human physiology (1)
- Human prostate (1)
- Humangenetik (1)
- Humans (1)
- Humeral fractures (1)
- Humerus (1)
- Hungary (1)
- Hydrocephalus (1)
- Hydroxyapatite (1)
- Hydroxychloroquine (1)
- Hydroxycut (1)
- Hydroxyurea (1)
- Hymenoptera venom immunotherapy (1)
- Hyperammonemic encephalopathy (1)
- Hypofractionated radiotherapy (1)
- Hyponatremia (1)
- Hypoxia inducible factor (1)
- Hypoxic responses (1)
- Hysterektomie-Prävalenz (1)
- I-FABP (1)
- I-PRF (1)
- ICSI (1)
- IDH mutation (1)
- IDH1 inhibitor (1)
- IDO1 (1)
- IFA (1)
- IFN (1)
- IFN-γ expression (1)
- IGF (1)
- IGRA (1)
- IKKε (1)
- IKZF1 (1)
- IL -17 (1)
- IL -23 (1)
- IL 23p19 knockout mouse (1)
- IL-11 (1)
- IL-12 (1)
- IL-13 (1)
- IL-15 (1)
- IL-18 binding protein (1)
- IL-18BP (1)
- IL-21 (1)
- IL-22 (1)
- IL-27 cytokine (1)
- IL-33 (1)
- IL10R (1)
- ILUVIEN (1)
- IMiD® (1)
- IPEX (1)
- IPS e.max system (1)
- IRES translation (1)
- ISS (1)
- ITGA7 (1)
- IUIS classification 2017 (1)
- IV iron (1)
- IVA interference tandem mass spectrometry (1)
- IVD degeneration (IVDD) (1)
- IVDU (1)
- IVF (1)
- Iceland (1)
- Idarucizumab (1)
- Identity (1)
- Idiopathic pulmonary fibrosis (IPF) (1)
- IgE (1)
- IgG (1)
- IgG substitution therapy (1)
- IgG4-related disease (1)
- IgGAM (1)
- Illumina (1)
- Image processing (1)
- Image processing (computer-assisted) (1)
- Imaging (1)
- Imaging genetics (1)
- Imaging in LGG (1)
- Imaging, three-dimensional (1)
- Immediate loading (1)
- Immediate placement (1)
- Immobilization (1)
- Immune Response (1)
- Immune cells (1)
- Immune receptor signaling (1)
- Immune response (1)
- Immune system (1)
- Immunity (1)
- Immunmodulation (1)
- Immunoassays (1)
- Immunocompromised (1)
- Immunoglobulin Therapy (1)
- Immunohistochemistry techniques (1)
- Immunological techniques (1)
- Immunologie (1)
- Immunology and Microbiology Section (1)
- Immunomodulation (1)
- Immunomonitoring (1)
- Immunosenescence (1)
- Immunostaining (1)
- Immunosuppression (1)
- Immunosuppressive Agents (1)
- Immunosuppressive agents (1)
- Immunosuppressive therapy (1)
- Impfung (1)
- Implant-supported bars (1)
- Implementación (1)
- Impulse control (1)
- In vivo (1)
- In-hospital cardiac arrest (1)
- In-line filtration (1)
- In-vivo (1)
- IncL (1)
- Incidence rate (1)
- Incomplete colonoscopy (1)
- Independent component analysis (1)
- Independent laboratories (1)
- Indeterminate biliary stricture (1)
- Index (1)
- Indication (1)
- Individualisierung des Studiums (1)
- Individualized intervention (1)
- Individuelle Studienbegleitung (1)
- Indonesia (1)
- Indoor air pollution (1)
- Induced membrane technique (1)
- Induced pluripotent stem cells (1)
- Induced sputum (1)
- Inertial motion capture (1)
- Infant (1)
- Infant leukemia (1)
- Infants (1)
- Infarction (1)
- Infections (1)
- Infectious disease (1)
- Infectious disease epidemiology (1)
- Infektionsabwehr (1)
- Infektionsprophylaxe (1)
- Infliximab (1)
- Inflow obstruction (1)
- Influenza (1)
- Information theory (1)
- Information transfer (1)
- Infusion management (1)
- Injuries (1)
- Injury (1)
- Inner ear therapy (1)
- Inpatients (1)
- Inside-out Signaling (1)
- Insula (1)
- Insulin (1)
- Insulin secretion (1)
- Insulin therapy (1)
- Integrated multimodal training (1)
- Integration (1)
- Integrin (1)
- Integrins (1)
- Intelligence (1)
- Intelligence tests (1)
- Intensive care outcome (1)
- Intensive care unit (1)
- Inter-study reproducibility (1)
- Interdisziplinarität (1)
- Interferon-free HCV treatment (1)
- Interferons (1)
- Interleukin-17A (1)
- Interleukin-18 (1)
- Interleukin-18 binding protein (1)
- Interleukin-22 binding protein (1)
- Intermediate filaments (1)
- International body passport (1)
- Internet citation (1)
- Interspecific competition (1)
- Interstitial lung diseases (ILD) (1)
- Interventional Trials (1)
- Interventional cardiology (1)
- Intervertebral disc degeneration (1)
- Intestinal failure-associated liver disease (1)
- Intestinal neoplasms (1)
- Intolerance (1)
- Intra-abdominal infection (1)
- Intracellular pathogens (1)
- Intracerebral haemorrhage (1)
- Intracranial embolism (1)
- Intracranial haemorrhage (1)
- Intracranial hemorrhage (1)
- Intragastric balloon (1)
- Intraoral scanners (1)
- Intraosseous access (1)
- Intratumoral (1)
- Intratympanic drug delivery (1)
- Intravenous Drug User (1)
- Intravenous injections (1)
- Invasive candidiasis (1)
- Invasive fungal infection (1)
- Invasive fungal infections (1)
- Inzidenzkorrektur (1)
- Ionenkanal (1)
- Ipilimumab (1)
- Ireb2 (1)
- Ireland (1)
- Iron Overload (1)
- Iron chelation (1)
- Iron deficiency (1)
- Irregular vaccination (1)
- Ischemia-reperfusion injury (1)
- Ischemia–reperfusion injury (1)
- Isolierung <Medizin> (1)
- Isoproterenol (1)
- Issue 96 (1)
- Italy (1)
- Itpr1 (1)
- Ivor Lewis esophagectomy (1)
- Ixodes ricinus (1)
- JAK inhibition (1)
- JNK3 (1)
- Jak2(V617F) (1)
- Joint destruction (1)
- Joint loading (1)
- Joubert syndrome (1)
- Jumping (1)
- Juvenile myoclonic epilepsy (1)
- KAP (1)
- KCGS (1)
- KCNJ2 mutation (1)
- KCNQ4 (1)
- KDIGO (1)
- KIF (1)
- KIF11 (1)
- KIR (1)
- KLK5 (1)
- KOOS IV (1)
- KRAS (1)
- Kaisidis plate (1)
- Karyotypes (1)
- Kegelschnecke (1)
- Keratinocytes (1)
- Ketogenic Diet (1)
- Ki-67 (1)
- Ki-67/MIB1 (1)
- Ki67 transgenic c‐myc/TGFα mice (1)
- Kidney Transplantation (1)
- Kidney disease (1)
- Kidney neoplasm (1)
- Kidney transplant recipients (1)
- Kiefer (1)
- Kim-1 (1)
- Kinases (1)
- Kinder (1)
- Kindheit (1)
- Kinematic posture analysis (1)
- Kinematics (1)
- Kinetochore (1)
- Klinische Ergebnisse (1)
- Klinische Fertigkeiten (1)
- Knee joint (1)
- Knockout (1)
- Kongress (1)
- Konsensus Methode (1)
- Konzeption (1)
- Konzeptpapier (1)
- Krait (1)
- Kraniomandibuläre Dysfunktion (1)
- Krebs (1)
- Krebsforschung (1)
- Kupffer cells (1)
- Kynurenine (1)
- Körperbild (1)
- Körpermodifikation (1)
- L1 cell-adhesion molecule (L1-CAM) (1)
- LABAs (1)
- LAMP3 (1)
- LAMTOR2 (1)
- LAT (1)
- LC-NE system (1)
- LC3 I/II (1)
- LC3B (1)
- LCH (1)
- LC–MS/MS (1)
- LDL (1)
- LDL-cholesterol (1)
- LFA-1 (1)
- LFP (1)
- LHRH receptor (1)
- LIR interaction, (1)
- LIVIN (1)
- LM11A 31 (1)
- LN229 (1)
- LNS (1)
- LOS (1)
- LPP (1)
- LRBA (1)
- LSCC (1)
- LTB4 (1)
- LTBI (1)
- LUBAC (1)
- LUT (1)
- Laboratory techniques and procedures (1)
- Lack of immunity (1)
- Lactation (1)
- Lactic acidosis (1)
- Lactobacillus (1)
- Lafora disease (1)
- Lamivudine (1)
- Landarztprogramm (1)
- Langzeitpflege (1)
- Laparoscopic fundoplication (1)
- Laparostomy (1)
- Laparotomy. Joel-Cohen (1)
- Laser navigation system (1)
- Late Gadolinium Enhancement (LGE) (1)
- Late gadolinium enhancement (1)
- Late presentation (1)
- Latent transforming growth factor β-binding protein 4 (1)
- Lateral recess stenosis (1)
- Laterality (1)
- Le carcinome épidermoïde oral (1)
- Leadership (1)
- Learning algorithms (1)
- Learning and memory (1)
- Learning outcomes (1)
- Leber congenital amaurosis (1)
- Lectin affinity plasmapheresis (1)
- Lecture (1)
- Leflunomide (1)
- Left Ventricular Mass (1)
- Left ventricular assist device (1)
- Left ventricular function (1)
- Left ventricular mass (1)
- Left ventricular non-compaction, (1)
- Leg alignment (1)
- Lehre (1)
- Lehrerausbildung (1)
- Leistungsorientierte Mittelvergabe (1)
- Leitlinie (1)
- Lenalidomide (1)
- Length of stay (1)
- Lentiviral vectors (1)
- Lernerfolgsmessung (1)
- Lernziele (1)
- Les macrophages associés aux tumeurs (1)
- Lesion (1)
- Leukemia (1)
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive (1)
- Leukocyte elastase (1)
- Leukocytes (1)
- Leukodystrophy (1)
- Leukotriene (1)
- Lice (1)
- Light sheet fluorescence microscopy (1)
- Lineage (1)
- Lineage tracing (1)
- Linkage (1)
- Lipid metabolism (1)
- Lipid signaling (1)
- Lipid trafficking (1)
- Lipidol (1)
- Lipiodol (1)
- Lipodystrophy (1)
- Lipopolysaccharide-binding protein (1)
- Liquid filled MicroLion ion chamber array (1)
- Lithium (1)
- Liver (1)
- Liver cancer (1)
- Liver enzymes (1)
- Liver injury (1)
- Liver metastases (1)
- Liver resection (1)
- Liver transplant (1)
- Liver-Related Complications (1)
- Liver-related complications (1)
- LiverTox (1)
- Livestock (1)
- LncRNA (1)
- LncRNA - long noncoding RNA (1)
- Local IgE (1)
- Local allergic rhinitis (1)
- Local climate (1)
- Local control (1)
- Localized prostate cancer (1)
- Locally advanced (1)
- Loco-regional control (1)
- Locomotor circuit (1)
- Lomentospora prolificans (1)
- Long term output (1)
- Long term result (1)
- Long-term (1)
- Long-term follow up (1)
- Longitudinal analysis (1)
- Low birth weight infant (1)
- Low volume prep (1)
- Low-dose X-irradiation (1)
- Low-dose ionizing radiation (1)
- Low-grade glioma (1)
- Low-virulent infection (1)
- Lower back pain (1)
- Lpar2 (1)
- Ltbp-4 (1)
- Ltbp-4L (1)
- Ltbp-4S (1)
- Ltbp4 (1)
- Lucigenin (1)
- Luftverkehr (1)
- Lumbar spinal canal stenosis (1)
- Lumbar stenosis (1)
- Lumican (1)
- Lung (1)
- Lung Cancer (1)
- Lung adenocarcinoma (1)
- Lung cancer (1)
- Lung failure (1)
- Lungenerkrankungen (1)
- Lyme Borreliosis (1)
- Lyme borreliosis (1)
- Lyme disease - Borreliosis (1)
- Lymph node (1)
- Lymphadenopathy (1)
- Lymphangiogenesis (1)
- Lymphangioleiomyomatosis (1)
- Lymphedema (1)
- Lymphocyte (1)
- Lymphoepithelioma (1)
- Lymphoid Neoplasia (1)
- Lymphoid tissues (1)
- Lymphoma (1)
- Lymphomas (1)
- Lysophosphatidic acids (1)
- Lysosomal storage disease (1)
- MACE (1)
- MAGGIC score (1)
- MAIT cell (1)
- MC-Fragen (1)
- MCP (1)
- MCP-1 (1)
- MDM2 (1)
- MDR1 (1)
- MEDIC (1)
- MEIS2 (1)
- MELD (1)
- MET (1)
- MK-0457 (1)
- MKP1 (1)
- MLC tracking (1)
- MLH1 (1)
- MLKL (1)
- MLL-rearranged leukemia (1)
- MLN8237 (1)
- MLV (1)
- MM-121 (1)
- MMF (1)
- MMP14 (1)
- MMP2 (1)
- MOLLI (1)
- MPA (1)
- MPM (1)
- MPN (1)
- MPN-U (1)
- MR spectroscopy (1)
- MR-based histology (1)
- MR-proADM (1)
- MR-spectroscopy (1)
- MRI patterns of gliomas (1)
- MRP4 (1)
- MSC-subsets (1)
- MSM (1)
- MTCL (1)
- MTRNR1 (1)
- MTT (1)
- MTT assay (1)
- Machine learning algorithms (1)
- Machine teaching (1)
- Macrophage Transdifferentiation (1)
- Macrophage polarization (1)
- Macular neovascularization (1)
- Magnetic resonance (1)
- Magnetic resonance imaging (MRI) (1)
- Magnetoencephalography (1)
- Magnetresonanztomografie (1)
- Maintenance treatment (1)
- Major bleeding (1)
- Major infection after cardiac surgery (1)
- Malaria prevalence (1)
- Malariae (1)
- Male (1)
- Male Population (1)
- MammaPrint (1)
- Mammalian target of rapamycin (1)
- Mammaplasty (1)
- Mammary gland (1)
- Manatee invariant (1)
- Mandible (1)
- Mania (1)
- Manner of death (1)
- Manufacturing (1)
- Maple bark disease (1)
- Maple bark strippers’ lung (1)
- Mapping (1)
- Marburg virus (1)
- Marginal grafts (1)
- Marker genes (1)
- Markov model (1)
- Massive Online Open Course (1)
- Mastectomy (1)
- Maternal morbidity (1)
- Mathematical methods (1)
- Mathematical model (1)
- Mathematical models (1)
- Mathematische Biologie (1)
- Mcl-1 (1)
- MdM2 (1)
- Measles (1)
- Measurement equipment (1)
- Mechanical ankle instability (1)
- Meckel’s diverticulum (1)
- Medical (1)
- Medical Education (1)
- Medical communication (1)
- Medical ethics (1)
- Medical hypoxia (1)
- Medical imaging (1)
- Medical implants (1)
- Medical management (1)
- Medical research (1)
- Medical school (1)
- Medical staff (1)
- Medical student (1)
- Medical traineeship (1)
- Medication changes (1)
- Medicine and health sciences (1)
- Medizin (1)
- Medizinische Abbildung (1)
- Medizinische Ausbildung (1)
- Medizinische Ethik (1)
- Medizinische Lehre (1)
- Medizinische Psychologie (1)
- Medizinstudierende (1)
- Melanoma (1)
- Membrane Attack Complex (1)
- Membrane Trafficking (1)
- Membrane assays (1)
- Membrane proteins (1)
- Membrane staining (1)
- Memory (1)
- Mena/VASP (1)
- Mental health (1)
- Mental health disorders (1)
- Mental health problems (1)
- Menthol (1)
- Mentor (1)
- Mesangial cells (1)
- Mesenchymal stem cell (1)
- Mesenchymal stem/stromal cells (1)
- Mesenchymal stromal cells (1)
- Mesenchymal stromal cells (MSC) (1)
- Mesh repair (1)
- Meta-analysis (1)
- Metaanalysis (1)
- Metabolic diseases (1)
- Metabolic syndrome (1)
- Metabolism (1)
- Metabolism, Inborn Errors (1)
- Metalloproteases (1)
- Metastasis (1)
- Metastatic (1)
- Metastatic castration-resistant prostate cancer (1)
- Metastatic tumors (1)
- Methacholine challenge test (1)
- Methicillin resistance (1)
- Methicillin-resistant Staphylococcus aureus (1)
- Methionine (1)
- Methoden (1)
- Methotrexate (1)
- Mgm1p (1)
- MiSpEx Network (1)
- Mice (1)
- Micro RNAs (1)
- Micro-CT (1)
- MicroRNA-181a (1)
- MicroRNAs (miRNAs) (1)
- Microalgae (1)
- Microarray (1)
- Microbial mutation (1)
- Microfluidics (1)
- Microglia (1)
- Microglial cells (1)
- Micrognathia (1)
- Microphones (1)
- Microphysiological models (1)
- Microsatellite instability (1)
- Microstates (1)
- Microtubule (1)
- Midbrain/brainstem expression changes (1)
- Middle East respiratory syndrome coronavirus (1)
- Midkine (1)
- Midline laparotomy (1)
- Midwifery (1)
- Migration (1)
- Mild cognitive impairment (1)
- Minimal Residual Disease (MRD) (1)
- Minimal core of imaging (1)
- Minimal invasive (1)
- Minimally invasive surgical procedures (1)
- Minimally invasive transforaminal interbody fusion (1)
- Mislocalised proteins (1)
- Mitochondrial ROS (1)
- Mitochondrial amino acid tRNA synthetases (1)
- Mitochondrial complex I (1)
- Mitochondrial disease (1)
- Mitochondrial disorder (1)
- Mitochondrial dysfunction (1)
- Mitochondrial function (1)
- Mitochondrial proteins (1)
- Mitochondrial respiration (1)
- Mitochondrial shuttles (1)
- Mitochondrien (1)
- Mitomycin C (1)
- Mitoxantrone (1)
- Mobilization (1)
- Model Organism (1)
- Modell-Curriculum (1)
- Modellprojekt, (1)
- Moderating factors (1)
- Modified FDI criteria (1)
- Molar tooth sign (1)
- Mole-rat (1)
- Molecular diagnostic testing (1)
- Molecular genetics (1)
- Molecular imaging (1)
- Molecular marker (1)
- Molecular matched therapy (1)
- Molecular signatures (1)
- Molecular subtype (1)
- Molecular subtypes (1)
- Molecular therapy (1)
- Molecularly targeted therapy (1)
- Molekulare Therapie (1)
- Monacolin K (1)
- Monitoring (1)
- Monoclonal antibodies (1)
- Monocytes and macrophages (1)
- Monolithic crown (1)
- Monosaccharide Transport Proteins (1)
- Monte Carlo method (1)
- Monte Carlo simulation (1)
- Morbus Crohn (1)
- Morphological modeling (1)
- Mortalitätskorrektur (1)
- Motility disorder (1)
- Motivating factor (1)
- Motor neuron disease (1)
- Motor skills (1)
- Mountain (1)
- Mouse model (1)
- Moviprep (1)
- Mucomaix® matrix (1)
- Mucopolysaccharidoses (1)
- Multi-center (1)
- Multi-modal feedback (1)
- Multi-nucleated cardiomyocytes (1)
- Multi-resistant pathogens (1)
- Multidetector Computed Tomography (1)
- Multidetector computed tomography (1)
- Multidisciplinary management (1)
- Multidrug-resistant bacteria (1)
- Multidrug-resistant tuberculosis (1)
- Multilevel two-part modelling (1)
- Multimedia (1)
- Multimodal imaging (1)
- Multimorbid patients (1)
- Multimorbilidad (1)
- Multinomial logistic regression (1)
- Multinucleated giant cells (1)
- Multiomics (1)
- Multiple Sclerosis (1)
- Multiple choice Fragen (1)
- Multiple myeloma (1)
- Multiple trauma (1)
- Multisensory (1)
- Multivariable analysis (1)
- Muscarinic acetylcholine receptor (1)
- Muscle atrophy (1)
- Muscle tissue (1)
- Muscular diseases (1)
- Musculoskeletal (1)
- Musculoskeletal ultrasound (1)
- Music chair concepts (1)
- Musical rhythm (1)
- Musician (1)
- Musician-specific seating position (1)
- Muskuloskeletales System (1)
- Muskuloskelettale Erkrankungen (1)
- Mutation databases (1)
- Mutations (1)
- Myalgia (1)
- Mycoses (1)
- Myelin or myeloarchitecture (1)
- Myelodysplastic syndrome (1)
- Myelofibrosis (1)
- Myeloperoxidase (1)
- Myeloproliferative disease (1)
- Myocardial perfusion (1)
- Myocardial revascularization (1)
- Myocardial segmentation (1)
- Myonecrosis (1)
- Myotonic dystrophy (1)
- Mφs (1)
- N-Acetylaspartate (1)
- N-acetyl-L-cysteine (1)
- N-acetylcysteine (1)
- N-cadherin (1)
- N-cadhérine (1)
- N-hydroxysuccinimide (1)
- N-methyl-D-aspartate receptor (1)
- N-myc (1)
- N2 (1)
- NADH dehydrogenase (1)
- NADPH oxidase 4 (1)
- NAFL (1)
- NCAM (1)
- NCH93 (1)
- NDBI (1)
- NDNF interneurons (1)
- NDR1 (1)
- NDUFA6 (1)
- NDUFAF8 (1)
- NEAT1 (1)
- NEAT2 (1)
- NETs (1)
- NF-ĸB (1)
- NF-κB pathway (1)
- NF-кB (1)
- NFAT (1)
- NFκB (1)
- NGS (1)
- NHE (1)
- NHEJ (1)
- NIRS (1)
- NK cell subset (1)
- NK receptors (1)
- NKG2A blocking (1)
- NKT cell (1)
- NMDA IgA/IgM antibodies (1)
- NMDA antibody (1)
- NMDAR subunit GluN2B (1)
- NMO-IgG (1)
- NO (1)
- NOD2 (1)
- NOXA (1)
- NPC disease (1)
- NPH insulin (1)
- NPSR1 (1)
- NRAS (1)
- NS1608 (1)
- NS3 protease inhibitor (1)
- NS3-4A protease inhibitor (1)
- NS3/4A protease inhibitors (PI) (1)
- NS5A inhibitors (1)
- NS5B polymerase inhibitor (1)
- NSAIDs (1)
- NSC350625 (1)
- NSE (1)
- NSF (1)
- NSG mice (1)
- NSTEMI (1)
- NXF1 (1)
- Nackenmuskulatur (1)
- NanoBone (1)
- Nanocrystalline (1)
- Nanoparticles (1)
- Nanopore (1)
- National catalogue of competence-based learning objectives in dentistry (1)
- Native T1 (1)
- Native T1 mapping (1)
- Natriuretic peptide (1)
- Naturwissenschaften (1)
- Nav channel activity (1)
- Nav1.7 (1)
- Neck muscles (1)
- Necrosis (1)
- Necrotic area (1)
- Necrotizing enterocolitis (1)
- Necrotizing fasciitis (1)
- Needs assessment [MeSH] (1)
- Negative staining (1)
- Negative-pressure wound therapy (1)
- Neoadjuvant radiochemotherapy (1)
- Neoadjuvant therapy (1)
- Neonatal (1)
- Neonatal brain damage (1)
- Neonatal intensive care unit (1)
- Neonatal morbidity (1)
- Neonatal outcome (1)
- Neonatal urea cycle disorders (1)
- Neosexualitäten (1)
- Nephrectomy (1)
- Nephrons (1)
- Nerves (1)
- Nervous system diseases (1)
- Nesplora Aquarium (1)
- Network analysis (1)
- Network model (1)
- Neugeborenes (1)
- Neural function (1)
- Neural networks (1)
- Neural stem cells (1)
- Neuro-ophthalmology (1)
- Neurobiology of disease and regeneration (1)
- Neuroblastoma (1)
- Neurochemistry (1)
- Neurodegeneration (1)
- Neurodegenerative diseases (1)
- Neurodevelopment (1)
- Neurodevelopmental disorders (1)
- Neuroendocrine cancer (1)
- Neurogenese (1)
- Neurogenesis (1)
- Neuromyelitis optica (1)
- Neuronal dendrites (1)
- Neuronal homeostasis (1)
- Neuronal networks (1)
- Neuronal nitric oxide synthase (1)
- Neuronal plasticity (1)
- Neuropathic pain (1)
- Neurophysiology (1)
- Neuropsychological testing (1)
- Neuropsychology (1)
- Neurotoxicity (1)
- Neurotransmitter (1)
- Neurowissenschaften (1)
- Neutrophils (1)
- New Developments (1)
- Next generation sequencing (1)
- Nfe2l2 (1)
- Niche differentiation (1)
- Nicolaides-Baraitser syndrome (1)
- Nicotine (1)
- Nimotuzumab (1)
- Nociception (1)
- Nodular lymphocyte predominant Hodgkin lymphoma (1)
- Non-RCT (1)
- Non-alcoholic fatty liver disease (1)
- Non-allergic-rhinitis (1)
- Non-aneurysmal (1)
- Non-clear cell renal cell cancer (1)
- Non-coding RNAs (1)
- Non-falciparum (1)
- Non-invasive brain stimulation (1)
- Non-neuronal cholinergic system (1)
- Non-nucleoside polymerase inhibitors (NNI) (1)
- Non-operative (1)
- Non-perimesencephalic (1)
- Non-responder (1)
- Non-small-cell lung cancer (1)
- Non-steroidal anti-inflammatory drugs (1)
- Non-trauma (1)
- Non-urothelial (1)
- Noncoding RNA (1)
- Noninferiority (1)
- Nonsteroidal anti-inflammatory drugs (1)
- Nonunion (1)
- Non–small-cell lung cancer (1)
- Nordic questionnaire (1)
- Notch (1)
- Novel treatment target (1)
- NoxA1 (1)
- Nucleolus (1)
- Nucleophosmin-1 (1)
- Nucleus pulposus cells (1)
- Numerical simulation (1)
- Nurses (1)
- Nursing (1)
- Nutrition (1)
- Nutrition risk stratification (1)
- Nymphs (1)
- O-GlcNAcylation (1)
- OCT (1)
- OECD performance standards (1)
- OGTT (1)
- ONC201 (1)
- OPRM1 methylation (1)
- OPS (1)
- OR time (1)
- OXA-48 (1)
- Object perception (1)
- Object vision (1)
- Objectives (1)
- Objektivität (1)
- Observational (1)
- Observational studies (1)
- Obstetric care (1)
- Obstetrics (1)
- Obstetrics and gynecology (1)
- Occupational Accidents (1)
- Occupational disease (1)
- Occupational exposure (1)
- Occupational health (1)
- Occupational medicine (1)
- Ocular findings (1)
- Oesophageal cancer (1)
- Oesophagogastric cancer oxaliplatin (1)
- Off-pump surgery (1)
- Offene Versorgung (1)
- Okinawa (1)
- Okinawa diet (1)
- Older adults (1)
- Oldest-old (1)
- Olfactory diagnostics (1)
- Olfactory system (1)
- Omics (1)
- Oncologic surgery (1)
- Oncolytic adenovirus (1)
- Oncolytic virus (1)
- Oncotargets (1)
- One health (1)
- Online-Lehre (1)
- Online-Lernen (1)
- Online-Magazine (1)
- Opacity (1)
- Open abdomen (1)
- Open repair (1)
- Open source concept (1)
- Opioids (1)
- Oposterior urethral valve (1)
- Opportunistic infections (1)
- Oppositional defant disorder (1)
- Oppositional defiant disorder (1)
- Optic nerve atrophy (1)
- Optical coherence tomography angiography (1)
- Optical lenses (1)
- Oral Health Impact Profile (OHIP) (1)
- Oral and maxillofacial trauma (1)
- Oral implantology (1)
- Ordinary least squares (OLS) (1)
- Organ allocation (1)
- Organ motion (1)
- Organ preservation (1)
- Organ rinse (1)
- Organ shortage (1)
- Organ support (1)
- Organoids (1)
- Organs at Risk (1)
- Oroantral communication (1)
- Orphan disease (1)
- Orthodontist (1)
- Oryctolagus cuniculus (1)
- Osimertinib (1)
- Osmosensing (1)
- OspE (1)
- Osteoinduction (1)
- Osteonecrosis (1)
- Osteoporosis diagnosis (1)
- Oswestry Disability Score (1)
- Outcome assessment [MeSH] (1)
- Outcomes research (1)
- Outpatients (1)
- Ovale (1)
- Ovarian carcinoma (1)
- Overall survival (1)
- Oxaliplatin (1)
- Oxidativer Stress (1)
- OxyELITE Pro (1)
- Oxygen (1)
- Oxygen consumption (1)
- Oxygen uptake (1)
- Oxygen-derived free radicals (1)
- P-gp (1)
- P1NP (1)
- P2X7 receptor (1)
- PAH (1)
- PAI-1 (1)
- PAR (1)
- PARK4 (1)
- PARK6 (1)
- PARK7 (1)
- PAX3/FOXO1 (1)
- PBMC (peripheral blood mononuclear cells) (1)
- PBPK simulation (1)
- PBX1 (1)
- PC12 cells (1)
- PC12 neuronal differentiation (1)
- PCP (1)
- PCSK9 protein (1)
- PCV (1)
- PD-1 (1)
- PD-1 inhibitor (1)
- PDCD4 (1)
- PDD - Assessment - Screening (1)
- PDE inhibition (1)
- PDE‐5‐inhibitor (1)
- PDI (1)
- PDK1 (1)
- PEA-15 (1)
- PEGylated PLGA (PLGA-PEG) (1)
- PEI (1)
- PELICAN (1)
- PEM-technology (1)
- PF-06273340 (1)
- PFL (1)
- PGE2 (1)
- PID prevalence (1)
- PIF pocket (1)
- PKA (1)
- PKCε (1)
- PKD (1)
- PKD/IC (1)
- PLK1 (1)
- PLK1 inhibitors (1)
- PLX4032 (1)
- PLX4720 (1)
- PM (1)
- PMF (1)
- PML (1)
- POLG (1)
- PPAR (Peroxisome proliferator-activated receptors) (1)
- PPARγ (1)
- PRG-1 (1)
- PRLTS3 (1)
- PRNT (1)
- PROM (1)
- PROMISE (1)
- PROTAC (1)
- PRRT2 (1)
- PRoMPT (1)
- PSA (1)
- PTCH (1)
- PTCH-1 (1)
- PTDM (1)
- PTEN (1)
- PTK2B (1)
- PUMA (1)
- PV (1)
- PXA (1)
- PYGL (1)
- Pacemaker (1)
- Paediatric Investigation Plan (1)
- Paediatric oncology (1)
- Paediatric research (1)
- Paediatrics (1)
- Pain management (1)
- Pain sensation (1)
- Pancreas transplantation (1)
- Pancreatic islet (1)
- Pancreatic surgery (1)
- Pancreatitis (1)
- Pancreatoduodenectomy (1)
- Panel testing (1)
- Panic disorder (1)
- Par-4 (1)
- Paracetamol (1)
- Parainfluenza (1)
- Paraneoplastic syndrome (1)
- Parapneumonic pleural effusion (1)
- Parent support (1)
- Parenteral nutrition (1)
- Parkinson (1)
- Parkinsonerkrankung (1)
- Parkinsons disease (1)
- Particles (1)
- Particulate matter (1)
- Patellofemoral Joint (1)
- Pathogen reduction (1)
- Pathogenesis (1)
- Pathologic changes (1)
- Pathological complete response (1)
- Pathologists (1)
- Pathology (1)
- Pathology Section (1)
- Patient Blood Management (1)
- Patient Outcome Assessment (1)
- Patient care planning (1)
- Patient education (1)
- Patient information materials (1)
- Patient isolation (1)
- Patient knowledge (1)
- Patient manikins (1)
- Patient preference (1)
- Patient preferences (1)
- Patient reported outcomes (1)
- Patient safety (1)
- Patient satisfaction (1)
- Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (1)
- Patient-centered care (1)
- Patient-reported outcomes (1)
- Pattern recognition receptors (1)
- Pause (1)
- Pdgfrβ (1)
- Pediatric burn injury (1)
- Pediatric neuroimaging (1)
- Pediatric sarcoma (1)
- Pediatrics (1)
- Pediatrics [MeSH] (1)
- Peer Teaching (1)
- Peer teaching (1)
- Peer-feedback (1)
- Peer-teaching (1)
- Peg3 (1)
- Pegylated liposomal doxorubicin (1)
- Penile carcinomas (1)
- Pentaglobin (1)
- Peptides and proteins (1)
- Percutaneous (1)
- Performing Artists (1)
- Pericardial effusion (1)
- Pericarditis (1)
- Perilymph (1)
- Perimesencephalic (1)
- Periodontal disease (1)
- Periodontal diseases (1)
- Periodontal therapy (1)
- Peripheral vascular disease (1)
- Personalised medicine (1)
- Personalisierte translationale Therapie (1)
- Personality (1)
- Personality disorder (1)
- Pessar (1)
- Petri net (1)
- Pfannenstiel (1)
- Pflege (1)
- Pflegeeinrichtungen (1)
- Pgrmc1 (1)
- Phagocytosis (1)
- Phantom study (1)
- Pharm-fMRI (1)
- Pharmaco-nutrition (1)
- Pharmacodynamic (1)
- Pharmacological treatment (1)
- Pharmacology (1)
- Pharmacometrics (1)
- Pharmacy setting (1)
- Pharmakoepidemiologie (1)
- Pharyngeal reflex (1)
- Phase 2 (1)
- Phase I trials (1)
- Phase II trial (1)
- Phase rotors (1)
- Phase-IV research (1)
- Philadelphia Chromosome (1)
- Philadelphia Chromosome-positive leukemia (1)
- Phospho-soda (1)
- Phospho-tau (1)
- Phospholipids (1)
- Physical activity (1)
- Physical environment (1)
- Physical fitness (1)
- Physical therapist (1)
- Physician report (1)
- Physician-assisted suicide (1)
- Phytochemicals (1)
- Piercing (1)
- Pierre Robin sequence (1)
- Pill Count (1)
- PillCamColon2 (1)
- Pilocytic astrocytoma (1)
- Pim-1 (1)
- Pink esthetic score (1)
- Placental growth factor (1)
- Planning target volume (1)
- Plasma (1)
- Plasma fibronectin (1)
- Plasma transfusion (1)
- Plasma usage (1)
- Plasmacytoid dendritic cell (1)
- Plasminogen (1)
- Plastic endoprosthesis (1)
- Platelet (1)
- Platelet dysfunction (1)
- Platelet lysate (1)
- Platelet releasate (1)
- Platzierung (1)
- Plectin (1)
- Pleural empyema (1)
- Plk1 (1)
- Plus-end (1)
- Pneumococcal conjugate vaccine (1)
- Pneumocystis jirovecii (1)
- Polarity index (1)
- Police (1)
- Poliomyelitis (1)
- Polo-like kinase 3 (1)
- PolySUMOylation (1)
- Polyhexanide (1)
- Polymerase Chain Reaction (PCR) (1)
- Polyphenole (1)
- Polyps (1)
- Polysomnography (1)
- Polyzystisches Ovarsyndrom (1)
- Política de Saúde (1)
- Pooling (1)
- Poor solubility (1)
- Population-based screening (1)
- Porin regulation (1)
- Portal (1)
- Portugal (1)
- Posaconazole serum level (1)
- Position paper (1)
- Positron-emission tomography (1)
- Post surgery pain (1)
- Post treatment (1)
- Post-transplant (1)
- Posterior Cerebral (1)
- Postoperative infections (1)
- Postoperative nutritional management (1)
- Posttranslational modification (1)
- Posttraumatic stress disorder (1)
- Posttraumatische Belastungsstörung (1)
- Posture (1)
- Posture analysis (1)
- Potassium channel Kir2.1 (1)
- Poverty (1)
- Practical training (1)
- Practice (1)
- Practice-based research network (1)
- Praktikum (1)
- Praktische Fertigkeiten (1)
- Pre-economic effects (1)
- Pre-emptive immunotherapy (1)
- Pre-treatment drug resistance mutations (1)
- PreS1 deletion (1)
- Precision (1)
- Precision oncology (1)
- Preclinical (1)
- Preclinical drug development (1)
- Preclinical research (1)
- Precompetitive development (1)
- Predictive medicine (1)
- Predominant polarity (1)
- Preeclampsia (1)
- Prenatal ultrasonographic detection rate (1)
- Preoperative diagnostics (1)
- Preoperative radiochemotherapy (1)
- Prepontine (1)
- Pressure pain (1)
- Presynaptic vesicles (1)
- Preterm birth (1)
- Preventive medicine (1)
- Pre‐Ligand Assembly Domain (PLAD) (1)
- Primary Care Health Centre (1)
- Primary breast lymphoma (1)
- Primary cilium (1)
- Primary health care (1)
- Primary health care [MeSH] (1)
- Primary prophylaxis (1)
- Primary sclerosing cholangitis (1)
- Primärversorgung (1)
- Prisoners (1)
- Prisons (1)
- Probability density (1)
- Probability distribution (1)
- Produkte zur Desinfektion (1)
- Professions (1)
- Profiling Transthiolation Activity (1)
- Profilometry (1)
- Progesteron (1)
- Progesterone (1)
- Prognostic biomarker (1)
- Programming languages (1)
- Prospective randomized Analysis (1)
- Prostaglandin (1)
- Prostate Cancer (1)
- Prostate cancer cell lines (1)
- Prostate-specific membrane antigen (1)
- Prosthetic rehabilitation (1)
- Protease activity (1)
- Proteasomes (1)
- Protective factors (1)
- Protein Kinase Inhibitors (1)
- Protein Structure (1)
- Protein Translocation (1)
- Protein aggregates (1)
- Protein complex (1)
- Protein degradation (1)
- Protein domains (1)
- Protein kinase (1)
- Protein purify derivative (1)
- Protein tyrosine modification (1)
- Protein-Kinasen (1)
- Protein-Protein Interactions (1)
- Proteinkinase (1)
- Proteins (1)
- Proteostasis (1)
- Protestantism (1)
- Prothrombin complex concentrate (1)
- Protokoll-Compliance (1)
- Prototypes (1)
- Proximal humeral fracture (1)
- Präanalytik (1)
- Prädiktive Validität (1)
- Prävalenz (1)
- Prüfung (1)
- Prüfungen (1)
- Prüfungserfolg (1)
- Prüfungsfragen (1)
- Pseudo HE-images (1)
- Psoriasis (1)
- Psoriasis vulgaris (1)
- Psycho-oncology (1)
- Psychodynamic psychotherapy (1)
- Psychological stress (1)
- Psychometric evaluation (1)
- Psychometrics (1)
- Psychopathology (1)
- Psychophysiologie (1)
- Psychosocial (1)
- Public and occupational health (1)
- Publication (1)
- Publication output (1)
- Pulmonary artery pressure (1)
- Pulmonary disease, chronic obstructive (1)
- Pulmonary embolism (1)
- Pulmonary failure (1)
- Pulse contour analysis (1)
- Pulse pressure variation (1)
- Pulsed SILAC (1)
- Pupillometry (1)
- Pustulosis (1)
- Pyruvate (1)
- Pädiatrische Brandverletzung (1)
- QA/QC (1)
- QOL (1)
- Qb-Test (1)
- QbTest® (1)
- Qualitative research (1)
- Qualitative research [MeSH] (1)
- Quality indicators (1)
- Quality management (1)
- Quality of Teaching and Learning (1)
- Quality of health care [MeSH] (1)
- Quality, performance, safety and outcomes (1)
- Qualität (1)
- Qualitätsmanagement (1)
- Qualitätssicherung (1)
- Qualitätssicherung der Lehre (1)
- Quantitative research (1)
- Quantitative sensory testing (1)
- Quantitative trait (1)
- Quantitative trait loci (1)
- Questionnaire (1)
- Questionnaire - Psychometrics - Diagnostics (1)
- Quinine (1)
- Quinolinate phosphoribosyltransferase (1)
- Quinolinic acid (1)
- R (1)
- R programming language (1)
- R software (1)
- RAD001 (1)
- RBC (1)
- RBC-depletion (1)
- RBFOX1 (1)
- RCT (1)
- RD cells (1)
- RDoC (1)
- REM sleep (1)
- REMS (1)
- RH30 cells (1)
- RIP1 (1)
- RMS (1)
- RNA Biology (1)
- RNA extraction (1)
- RNA polymerase (1)
- RNA polymerase inhibitors (1)
- RNA processing (1)
- RNA processing machinery (1)
- RNA therapeutics (1)
- RNA therapy (1)
- RNA viruses (1)
- RNA, long noncoding (1)
- RNA-Interferenz (1)
- RNA-sequencing (1)
- RNA-templated DNA repair (1)
- RNActive (1)
- RNAi (1)
- RNAi and CRISPR screens (1)
- RNAseq analysis (1)
- RNF4 (1)
- ROS generation (1)
- ROS/RNS (1)
- ROS1 (1)
- RPE65 (1)
- RT-qPCR (1)
- RTS (1)
- RUFY (1)
- RULA (1)
- RUNX1/ETO (1)
- Rab proteins (1)
- Rab7 (1)
- Rac1 (1)
- Radial artery (1)
- Radiation exposure (1)
- Radiation induced diarrhoea (1)
- Radical cystectomy (1)
- Radical nephrectomy (1)
- Radiochemotherapy (1)
- Radiofrequency (1)
- Radiology and imaging (1)
- Radiyal arter (1)
- Rahmenbedingungen der Lehre (1)
- Rainfall (1)
- Raman spectroscopy (1)
- Ramón y Cajal (1)
- Random forest (1)
- Randomised controlled trial (1)
- Randomised trial (1)
- Randomized (1)
- Randomized controlled trials (1)
- Randomized trial (1)
- RapL (1)
- Rapamycin (1)
- Rapid diagnostic test (1)
- Rapid eye movement sleep behavior disorder (1)
- Rare Diseases (1)
- Rare disease (1)
- Ratewahrscheinlichkeit (1)
- Rational use (1)
- Re-exploration (1)
- Re-exposure (1)
- Re-injury (1)
- Readmission (1)
- Real-time phase contrast (1)
- Real-world data (1)
- Real-world evidence (1)
- RealTime (1)
- Rearing temperature (1)
- Recall rate (1)
- Receptor physiology (1)
- Reconstructed human epidermis (1)
- Reconstruction (1)
- Reconstructive surgical procedures (1)
- Recurrence (1)
- Recurrence rate (1)
- Red blood cells (1)
- Red yeast rice (1)
- Redox (1)
- Redox modification (1)
- Redox-sensitive GFP (1)
- Reference (1)
- Refractory ALL (1)
- Regenerative medicine (1)
- Regulatory T cells (1)
- Regulatory framework (1)
- Regulatory networks (1)
- Rehabilitation (1)
- Rehospitalization (1)
- Reintervention (1)
- Reisefieber (1)
- Rejection (1)
- Rekonstruktive chirurgische Verfahren (1)
- Relapse (1)
- Relapsed ALL (1)
- Relaxometry (1)
- Release of mtDNA and mtRNA (1)
- Remission (1)
- Remote ischemic conditioning (1)
- Remote monitoring (1)
- Renal cancer (1)
- Renal function (1)
- Renal lesions (1)
- Renal replacement therapy (1)
- Repatriation of corpses (1)
- Reperfusion (1)
- Replication study (1)
- Repositioning drugs (1)
- Reproducibility (1)
- Reproduktionsmedizin (1)
- Research Article (1)
- Research trends (1)
- Reservoir function (1)
- Residential care (1)
- Residential facilities (1)
- Resin composites (1)
- Resource competition (1)
- Respimat® Soft Mist™ Inhaler (1)
- Respiratory Syncytial Virus (1)
- Respiratory infections (1)
- Respiratory signs and symptoms (1)
- Respiratory syncytial virus (1)
- Respiratory tract diseases (1)
- Response (1)
- Response criteria (1)
- Ressourcen (1)
- Restenosis (1)
- Resting state (1)
- Resting-state (1)
- Restricted posture (1)
- Resuscitation (1)
- Reticulon (1)
- Retina (1)
- Retinal degeneration (1)
- Retro-IDEAL (1)
- Retrospective studies (1)
- Return to play (1)
- Return to sports (1)
- Reverse transcription polymerase chain reaction (1)
- Review (1)
- Rezidivrate (1)
- Rheumatology (1)
- Rho GTPases (1)
- Rho/Rho-kinase (1)
- RhoA (1)
- RhoGTPases (1)
- Ribosomal S6 phosphorylation (1)
- Ribosomal translation (1)
- Ribosomes (1)
- Right hemisphere (1)
- Risk assessment (1)
- Risk factor (1)
- Risk factors (1)
- Risk prediction (1)
- Risk reduction (1)
- Risk stratification (1)
- Rivaroxaban (1)
- Robotic Radiosurgery (1)
- Robotic tracking (1)
- Roe deer (1)
- Rolandic Spikes (1)
- Roma women (1)
- Rora (1)
- Roughness (1)
- Round window membrane (1)
- Routinedaten (1)
- Roux-en-Y gastric bypass (1)
- Rtn3 (1)
- Ruijs-Aalfs syndrome (1)
- Rural area (1)
- Rush (1)
- Rush protocol (1)
- Rush-SIT (1)
- Ruxolitinib (1)
- Ryanodine (1)
- S. cerevisiae (1)
- S100 calcium‑binding protein B (1)
- S100b (1)
- S1P lyase (1)
- S1P1 receptor (1)
- S1P1–5 (1)
- S1PR1 (1)
- S1PR4 (1)
- SAGE (1)
- SAH close (1)
- SAMHD1 (1)
- SAMHD1 knockout mouse (1)
- SAMHD1 phosphorylation (1)
- SAP (1)
- SARS coronavirus (1)
- SARS-CoV (1)
- SAVI (1)
- SCA34 (1)
- SCA38 (1)
- SCCHN (1)
- SCMR (1)
- SCT (1)
- SDF-1 (1)
- SDH (1)
- SDS (1)
- SENP (1)
- SENP6 (1)
- SERS (1)
- SF-36 (1)
- SHH (1)
- SIADH (1)
- SILAC (1)
- SIRT1 (1)
- SKI II (1)
- SLC20A1 (1)
- SLP-76 (1)
- SMAD (1)
- SMAD signaling (1)
- SNP (1)
- SOCS (1)
- SOD (1)
- SOFA (1)
- SPARTAN (1)
- SPRTN (1)
- SPSS (1)
- SR protein (1)
- SR-BI (1)
- SRSF3 (1)
- SRSF7 (1)
- ST2L (1)
- STAMPE2 (1)
- STAT1 (1)
- STAT5 (1)
- STDP (1)
- STIR (1)
- SUMO (1)
- SUMO chains (1)
- SUMO1-3 (1)
- SUMOylation (1)
- SUN1 (1)
- SUN2 (1)
- SUV (1)
- SVR (1)
- SW480 Cell (1)
- SW480 cells (1)
- SWATH (1)
- Saccades (1)
- Saccadometry (1)
- Safety equipment (1)
- Safety learning (1)
- Salivary gland diseases (1)
- Salmonella choleraesuis (1)
- Salmonella infection (1)
- Salt inducible kinase 2 (SIK2) (1)
- Salvage therapy (1)
- Sarcomas (1)
- Sarcopenia (1)
- Sarkoidose (1)
- Sauerstoffpartialdruck (1)
- Scedosporium spp. (1)
- Scheimpflug imaging (1)
- School support (1)
- Science structure (1)
- Scientifi c competence (1)
- Scientific community (1)
- Scientific publishing (1)
- Scientometria (1)
- Scientometric analysis (1)
- Scientometrics (1)
- Scientometry (1)
- Sclerostin (1)
- Screening guidelines (1)
- Seattle heart failure model (1)
- Second stage of labor (1)
- Second-line treatment (1)
- Secondary injury cascades (1)
- Secondary prevention (1)
- Secretion (1)
- Seizure (1)
- Seizures (1)
- Selection bias (1)
- Selective autophagy (1)
- Selenium (1)
- Selenium administration in gynecologic radiation oncology (1)
- Selenoproteins (1)
- Self-assessment (1)
- Self-efficacy (1)
- Self-expandable metal stent (SEMS) (1)
- Self-expandable metal stents (1)
- Self-expandable metal stents complications (1)
- Self-management support (1)
- Self-myofascial release (1)
- Self-renewal (1)
- Self-report (1)
- Seltene Erkrankungen (1)
- Semicontinuous (1)
- Semitendinosus tendon autograft (1)
- Sensitivity (1)
- Sensorimotor processing (1)
- Sensorimotor training (1)
- Sensory Neuroscience (1)
- Sensory neuron (1)
- Sensory perception (1)
- Sensory systems (1)
- Sepsis-bundle (1)
- Septic shock (1)
- Sequence (1)
- Sequence alignment (1)
- Sequence motif analysis (1)
- Sequential (1)
- Seribantumab (1)
- Serine proteases (1)
- Seroconverter (1)
- Seroepidemiology (1)
- Seroprevalence (1)
- Serotype 3 (1)
- Serum (1)
- Serum Susceptibility (1)
- Severe Acute Respiratory Syndrome (1)
- Severe bacterial infection (1)
- Severe blood loss (1)
- Severe malaria (1)
- Severity of illness index (1)
- Sex (1)
- Sexual Dysfunctions (1)
- Sexual child abuse (1)
- Sexual violence (1)
- Sexualmedizin (1)
- Sexuelle Dysfunktionen (1)
- Sexuelle Gewalt (1)
- Sexuelle Revolution (1)
- Sexueller Kindesmissbrauch (1)
- Shannon index (1)
- Sharpin (1)
- Sholl analysis (1)
- Shone’s complex (1)
- Short bowel syndrome (1)
- Shoulder joint (1)
- Shunt (1)
- Sickle Cell Disease (1)
- Signal Transduction (1)
- Signal transduction (1)
- Signaling ROS (1)
- Signaling pathway (1)
- Silicosis (1)
- Silver in situ hybridization (1)
- Simulation and modeling (1)
- Simulation komplexer Systeme (1)
- Simulation training (1)
- Simultaneous (1)
- Single-Molecule Localization Microscopy (SMLM) (1)
- Single-cell RNA-seq (1)
- Single-cell RNA-sequencing (1)
- Sistemas de Saúde (1)
- Skeletal muscle (1)
- Skills training (1)
- Skin fibroblast (1)
- Skin irritation test (1)
- Skin manifestation (1)
- Skin morphology (1)
- Skp (1)
- Slc11a2 (1)
- Slc25a37 (1)
- Sleep deprivation (1)
- Smac mimetic (1)
- Small bowel (1)
- Small bowel atresia (1)
- Small bowel endoscopy (1)
- Small molecules (1)
- Small- and medium-sized enterprises (1)
- Small-cell lung cancer (1)
- Smart nebulizer (1)
- Smoking habits (1)
- Smooth muscle (1)
- Smooth muscle cell (1)
- Snakebite (1)
- Social Media (1)
- Social communication (1)
- Social epidemiology (1)
- Social health determinants (1)
- Social information processing (1)
- Social phobia (1)
- Social research (1)
- Social sciences (1)
- Social skills training (1)
- Social support (1)
- Socio-economic analysis (1)
- Soft skills (1)
- Soft tissue infection (1)
- Soft-tissue sarcoma (1)
- Software tool (1)
- Software tools (1)
- Solidworks 2015 (1)
- SoloSTAR (1)
- Somatization (1)
- Sonication (1)
- Source reconstruction (1)
- Sozialpsychiatrischer Dienst (1)
- Spa water (1)
- Spanish National Health System (1)
- Species identification (1)
- Speciesidentification (1)
- Specimen preparation and treatment (1)
- Spectral library (1)
- Spectraldomain OCTA (1)
- Spectrin (1)
- Speech (1)
- Speech signal processing (1)
- Sphere Formation Assay (1)
- Sphingolipid (1)
- Sphingosine 1-phosphate (1)
- Sphingosine-1-phosphate (1)
- Spinal cord (1)
- Spine Register (1)
- Spine density (1)
- Spinocerebellar ataxia (1)
- Spirochetes (1)
- Splanchnic Hemodynamics (1)
- Spleen (1)
- Splenic dendritic cell (1)
- Splice variants (1)
- Spondyloarthritis (1)
- Spondylolisthesis (1)
- Spontaneous bacterial peritonitis (1)
- Sports (1)
- Spot sign (1)
- Squamous cell carcinoma (1)
- StUbL (1)
- Staatsexamen (1)
- Standard risk (1)
- Standardized operating procedures (1)
- Standards of care (1)
- Standardverfahren (1)
- Staphylococcus aureus (1)
- Starvation (1)
- Statistical methods (1)
- Status epilepticus (1)
- Stavudine (1)
- Steatosis (1)
- Stenosis (1)
- Stenotrophomonas maltophilia (1)
- Stentoplasty (1)
- Sterblichkeit (1)
- Stereotactic radiosurgery (1)
- Steroid (1)
- Stilbene (1)
- Stimulation experiments (1)
- Stimulus-secretion coupling (1)
- Stoma (1)
- Stress (1)
- Stress and resilience (1)
- Stress resilience (1)
- Striatum (1)
- Stringed bow player (1)
- Stroke prevention (1)
- Stroke volume variation (1)
- Stromal cell (1)
- Structural MRI (1)
- Structural genomics (1)
- Structured reporting (1)
- Strukturwandel der Sexualität (1)
- Students (1)
- Studiendauer (1)
- Studium mit Kind (1)
- Störfaktoren (1)
- Sub-segmentation (1)
- Subacute cerebellar degeneration (1)
- Subarachnoid Hemorrhage (1)
- Subcutaneous (1)
- Subgroup identification (1)
- Subpopulation (1)
- Substances for disinfection (1)
- Subterranean (1)
- Sudden cardiac death (1)
- Suicidal behavior (1)
- Suicidal ideation (1)
- Suicidal thoughts (1)
- Sulfasalazine (1)
- Sulfhydryl-reactivity (1)
- Sulfur metabolism (1)
- Sumatra (1)
- Superimposition (1)
- Superinfection (1)
- Supplemental parenteral nutrition (1)
- Supplementation (1)
- Supraspinatus tendon (1)
- Supraventricular arrhythmias (1)
- Surface (1)
- Surgical ICU (1)
- Surgical risk (1)
- Surgical site occurrence (1)
- Surveillance (1)
- Surveys (1)
- Survival data (1)
- Sustainable Development (1)
- Sustained virological response (SVR) (1)
- Sweat osmolality (1)
- Sweat secretion rate (1)
- Swept-source OCTA (1)
- Switzerland (1)
- Sycamore (1)
- Syllables (1)
- Sympathicolysis (1)
- Symptome (1)
- Symptoms (1)
- Synapses (1)
- Synaptic dysfunction (1)
- Synaptopodin (1)
- Syncope (1)
- Syndrome des ovaires polykystiques (1)
- Synovial inflammation (1)
- Synovial sarcoma (1)
- Synthetic (1)
- Systematic review (1)
- Systemic inflammatory response (1)
- Systemic lupus erythematosus (1)
- Systemic treatment (1)
- Systems biology (1)
- Systems medicine (1)
- T Cells (1)
- T cell receptors (1)
- T cell/histiocyte rich large B cell lymphoma (1)
- T helper 17 cells (1)
- T-ALL (1)
- T-DM1 (1)
- T-cell homeostasis (1)
- T-cell homing (1)
- T-cell niche (1)
- T-cell receptor (1)
- T-cell targeting (1)
- T-cells (1)
- T-lymphocytes (1)
- T-tubule system (1)
- T1 (1)
- T1 and T2 mapping (1)
- T1 mapping (1)
- T84 colon carcinoma cells (1)
- TACE (1)
- TALE-homdomain protein (1)
- TAPSE (1)
- TAVI (1)
- TAVR (1)
- TAX1BP1 (1)
- TBK1 (1)
- TC stenosis (1)
- TCR signaling cascade (1)
- TEER (1)
- TEM (1)
- TEVAR (1)
- TG-186 (1)
- TG-43 (1)
- TGF-beta (1)
- TGF-β (1)
- TGF-β1 (1)
- THV (1)
- TIA-1 (1)
- TIC10 (1)
- TILs (1)
- TIM23 (1)
- TIMP2 (1)
- TL AOSIS (1)
- TLR (1)
- TLR2/6 (1)
- TLR7 (1)
- TLR8 (1)
- TMC435 (1)
- TMEM126B (1)
- TMS (1)
- TMS-EEG (1)
- TMT (1)
- TNF (1)
- TNF inhibitors (1)
- TNF-α (1)
- TNFR1 (1)
- TOR inhibitor (1)
- TOR1A (1)
- TP53 (1)
- TP53 mutation status (1)
- TP53-induced glycolysis and apoptosis regulator (1)
- TPR (1)
- TRAPP (1)
- TRIM25 (1)
- TRPA1 (1)
- TSC (1)
- TSC-associated neuropsychiatric disorders (1)
- TSC22D3 (1)
- TVT (1)
- TWINKLE (1)
- Tabakkonsum (1)
- Tagging (1)
- Tailored medicine (1)
- Tailored therapy (1)
- Tamponade (1)
- Targeted therapies (1)
- Targeted tumor therapy (1)
- Tas2r126 (1)
- Tas2r135 (1)
- Tas2r143 (1)
- Tattoo (1)
- Tau (1)
- Tau acetylation (1)
- Tax effect (1)
- Taxane (1)
- Taxonomy (1)
- Tea (1)
- Teaching and Learning conditions (1)
- Technicians (1)
- Technique (1)
- Telemedicine (1)
- Telomere length (1)
- Telomeres (1)
- Temozolomide (1)
- Temporal lobe epilepsy (1)
- Temsirolimus (1)
- Tendon incontinence repair (1)
- Tendon transplantation (1)
- Term birth (1)
- Testosterone (1)
- Tet-inducible system (1)
- Texture analysis (1)
- Tfrc (1)
- Tgfβ (1)
- Th1 polarization (1)
- Theft (1)
- Theorie der Sexualität (1)
- Therapeutics (1)
- Therapy response (1)
- Thermal injury (1)
- Thermal spring water (1)
- Thermische Verletzung (1)
- Thermodilution (1)
- Thermoplasma (1)
- Thiol redox modification (1)
- Three-dimensional back scan (1)
- Three-dimensional echocardiography (1)
- Thrombosis/hypercoagulable states (1)
- Thrombotic microangiopathy (1)
- Thrombotic thrombocytopenic purpura (1)
- Thromboxane (1)
- Thymocytes (1)
- Thymus (1)
- Thyroid (1)
- Thyroid disease (1)
- Tick (1)
- Tick-Borne diseases (1)
- Tick-borne encephalitis (1)
- Ticks (1)
- Time in therapeutic range (TTR) (1)
- Time optimization (1)
- Time series (1)
- Time to treatment failure (1)
- Timing (1)
- Tinnitus (1)
- Tissue microarray (TMA) (1)
- Tissue stiffness (1)
- Toll-like receptor (TLR) 6 (1)
- Toll-like receptors (1)
- Tomography (1)
- Tonsil (1)
- Tools and ressources (1)
- Tooth transplantation (1)
- Topoisomerase (1)
- Total colonoscopy (1)
- Total hip replacement (1)
- Total operating room time (1)
- Toxicology (1)
- Tozasertib (1)
- Tracheal Intubation (1)
- Tranexamic acid (1)
- Transcatheter Aortic Valve Implantation (1)
- Transcatheter based aortic valve implantation (1)
- Transcription (1)
- Transcriptional control (1)
- Transcriptome (1)
- Transcriptome analysis (1)
- Transcriptome microarray (1)
- Transduction (1)
- Transesophageal echocardiography (1)
- Transfer model (1)
- Transferases (1)
- Transformation (1)
- Transgender (1)
- Transgenic SK-2 mice (1)
- Transient (1)
- Transient elastography (1)
- Transient ischemic attack (1)
- Transition invariant (1)
- Transitional cell carcinoma (1)
- Translation initiation (1)
- Translational (1)
- Transmembrane communication (1)
- Transplantation (1)
- Transportation (1)
- Trastuzumab (1)
- Trauma surgery (1)
- Traumatic brain injury (1)
- Travellers (1)
- Treatment modification (1)
- Treatment protocol (1)
- Trees (1)
- Treg cell (1)
- Triamcinolone acetonide (1)
- Trichuris suis ova (1)
- Triple negative (1)
- Triple therapy (1)
- Triple-negative breast cancer (1)
- Trk (1)
- TrkC (1)
- Tropenmedizin (1)
- Troponin (1)
- Trousseau’s syndrome (1)
- Trueness (1)
- Tubers (1)
- Tularemia (1)
- Tumor growth (1)
- Tumor heterogeneity (1)
- Tumor infiltrating lymphocytes (1)
- Tumor interstitial fluid pressure (1)
- Tumor obstruction (1)
- Tumor suppressor protein (1)
- Tumor volume (1)
- Tumormarker (1)
- Tumorsphere Formation (1)
- Tumour biomarkers (1)
- Tumour immunology (1)
- Turkish (1)
- Tween20 (1)
- Twist (1)
- Two-hit hypothesis (1)
- Type 2 Diabetes mellitus (1)
- Type 2 diabetes (1)
- Tyrosine kinase inhibitor (1)
- Tyrosine kinase inhibitor mTOR inhibition (1)
- Tyrosine kinases (1)
- U-87MG (1)
- UDP-glucose ceramide glycosyltransferase (1)
- UGCG (1)
- ULBP4 (1)
- UPPS (1)
- USP9X (1)
- UVA (1)
- UWB diagnostics (1)
- Ubiquitin (1)
- Ubiquitin Ligase (1)
- Ubiquitin kinase PINK1 (1)
- Ubiquitylation (1)
- Ultra microscopy (1)
- Ultra-rush protocol (1)
- Ultrasonic nebulizer (1)
- Ultrasound imaging (1)
- Umbilical cord (1)
- Underfeeding (1)
- Undergraduate medical education (1)
- Undergraduate training (1)
- Undergraduates (1)
- Unilateral hip osteoarthritis (1)
- United States (1)
- União Européia (1)
- Unterdruckwundtherapie (1)
- Upper body posture (1)
- Upper respiratory tract infection (1)
- Urban (1)
- Ureter (1)
- Urethral cancer (1)
- Urothelial cancer (1)
- Urothelial carcinoma (1)
- Urothelial cells (1)
- Urticaria (1)
- Usutu virus (1)
- Uveal melanoma (1)
- V4 (1)
- VARGADO (1)
- VASP (1)
- VBM (1)
- VE-cadherin (1)
- VEGF receptors (1)
- VEGFA (1)
- VEGFR (1)
- VEGFR-2 (1)
- VEGFR-3 (1)
- VHH (1)
- VIP (1)
- VIP1 (1)
- VIS (1)
- VISTA (1)
- VLA4 (1)
- VPA-analogues (1)
- VPAC1 (1)
- VRE (1)
- VX680 (1)
- Vaccination breakthrough (1)
- Vaccine (1)
- Vaccine breakthrough (1)
- Vacuoles (1)
- Vaginal breech delivery (1)
- Vaginal delivery (1)
- Validierungsstudie (1)
- Validity (1)
- Value-added effect (1)
- Variant histology (1)
- Vascular biology (1)
- Vascular emergencies (1)
- Vascular endothelial growth factor A (1)
- Vascular endothelial growth factor receptor 2 (1)
- Vascular permeability (1)
- Vasculogenesis (1)
- Vector mosquito (1)
- Vector-borne infections (1)
- Vein (1)
- Veino-lymphatic separation (1)
- Vemurafenib (1)
- VeroE6‐eGFP cells (1)
- Versorgungsforschung (1)
- Versorgungsstrukturen (1)
- Vertebral augmentation (1)
- Vertebral body stenting (1)
- Vertebral fracture (1)
- Vertigo (1)
- Veränderungsmanagement (1)
- Vespid venom allergy (1)
- Victimization (1)
- Video-oculography (1)
- Videolaryngoscopy (1)
- Vincristine (1)
- VirB (1)
- Viral Load (1)
- Viral core (1)
- Viral infection (1)
- Viral replication (1)
- Virchow-Robin Spaces (1)
- Virological Failure (1)
- Virological Response (1)
- Virological failure (1)
- Virotherapy (1)
- Virtual implant planning (1)
- Visual impairments (1)
- Visual quality (1)
- Visual system (1)
- Vitamin (1)
- Vitamin K antagonists (1)
- Vitreous opacity (1)
- Vitreous samples (1)
- Voltage attenuation (1)
- Volume overload (1)
- Volumetric analysis (1)
- Volumetric indexes (1)
- Voriconazole (1)
- Vorkenntnisse (1)
- Vorklinik (1)
- Voxel-based morphometry (1)
- WNT (1)
- WRNIP1 (1)
- WT1 (1)
- WYE-354 (1)
- Wait and see (1)
- Wakefulness (1)
- Water chemistry (1)
- Weak bases (1)
- Wearable cardioverter‐defibrillator (1)
- Web 2.0 (1)
- Weight loss (1)
- West Nile fever (1)
- West Nile neuroinvasive disease (1)
- West Nile virus (1)
- Westphal-Paradigm (1)
- White blood cells (1)
- Whole genome association (1)
- Willensfreiheit (1)
- Wilms tumor (1)
- Wing morphometry (1)
- Wnt (1)
- WoMo score (1)
- Women in medicine (1)
- Women in science (1)
- Work shadowing (1)
- Workplace (1)
- Workplace ergonomics (1)
- Wound healing potential (1)
- X-ray Crystallography (1)
- X-ray crystallography (1)
- XL probe (1)
- Xenorhabdus (1)
- YB-1 (1)
- YK-4-279 (1)
- YM155 (1)
- YWHAE (1)
- YWHAZ (1)
- Yarrowia lipolytica (1)
- Yarrowia lipolytica mitochondrial genome complex I NADH: ubiquinoneoxidoreductase (1)
- Yellow fluorescent protein (1)
- Zebrafish (1)
- Zellbiologie (1)
- Zellulärer Transport (1)
- Zervixverkürzung (1)
- Zika (1)
- Zika fever (1)
- Zika vaccine (1)
- Zirconia (1)
- Zoopotentation (1)
- Zooprophylaxis (1)
- Zulassung zum Medizinstudium (1)
- Zulassungskriterien (1)
- Zwangseinweisungen (1)
- a disintegrin and metalloprotease 10 (ADAM10) (1)
- abdominal imaging (1)
- abemaciclib (1)
- ablation (1)
- ablation techniques (1)
- abnormal tumor vasculature (1)
- abuso (1)
- academic (1)
- academic medicine (1)
- acceptable change limit (1)
- accident (1)
- accidental falls [MeSH] (1)
- accidents (1)
- acetylation (1)
- acetylcholine binding protein (1)
- acetylcholine receptors (1)
- acetylcholinesterase (1)
- acetylcholinesterase (AChE) inhibition (1)
- acetylcholinesterase inhibition (1)
- acid dentine lysate (1)
- acid sphingomyelinase (ASMase; Smpd1) (1)
- acneiform skin toxicity (1)
- acoustic radiation force impulse imaging (1)
- acquired drug resistance (1)
- actin cytoskeleton (1)
- actin dynamics (1)
- action sounds (1)
- action-effect association (1)
- activation receptors (1)
- active/deactive transition (1)
- activities of daily life (1)
- activity-based benefits (1)
- actography (1)
- acupuncture (1)
- acute and chronic graft versus host disease (a/c GVHD) (1)
- acute attacks (1)
- acute cholecystitis (1)
- acute chronic inflammation (1)
- acute coronary syndromes (1)
- acute decompensation of cirrhosis (1)
- acute exacerbations of COPD (1)
- acute inflammation (1)
- acute leukemia (1)
- acute liver failure (1)
- acute liver injury (1)
- acute lung injury (ALI) (1)
- acute lymphatic leukemia (1)
- acute lymphoblastic leukaemia (1)
- acute myeloid leukemia (AML) (1)
- acute respiratory distress syndrome (1)
- acute-on-chronic liver failure (ACLF) (1)
- acute‐on‐chronic liver failure (1)
- adaptation plan (1)
- adaptive cardiac remodelling (1)
- adaptive immune escape (1)
- adaptive immunity (1)
- adeno-associated virus (1)
- adenocarcinoma (1)
- adenomatous polyposis (1)
- adenosine receptors (1)
- adeno‐associated virus (1)
- adipocytes (1)
- adiponectin (1)
- adipose tissue (1)
- adipose tissue-derived stem cell (1)
- adipose-derived stem cells (1)
- adipose-derived stem cells (ASCs) (1)
- adiposity (1)
- adjustment disorder (1)
- adjuvant chemotherapy (1)
- adjuvant radiotherapy (1)
- admission criteria (1)
- adolescence (1)
- adolescentes (1)
- adolescents’ health (1)
- adoptive cell therapy (1)
- adoptive immunotherapy (1)
- adrenal insuffciency (1)
- adrenoceptors (1)
- adult and elderly patients (1)
- adult attention deficit/hyperactivity disorder (adult ADHD) (1)
- adult congenital heart disease (1)
- adult neurogenesis (1)
- advance directive (1)
- advanced breast cancer (1)
- advanced glycation end products (1)
- adverse effects (1)
- adverse events (1)
- aerobic exercise (1)
- aerodynamics (1)
- aerosol (1)
- aesthetics (1)
- affective disorder (1)
- affective disorders (1)
- affinity purification (1)
- affordance (1)
- aftercare structures (1)
- aged [MesH] (1)
- aggressiveness (1)
- agonists (1)
- air pollution (1)
- air pouch (1)
- airborne bacteria (1)
- airway (1)
- airway remodeling (1)
- alcohol dehydrogenase (ADH) (1)
- alcohol metabolism (1)
- alcohol use disorder (1)
- alcoholic liver disease (1)
- alcoholic liver injury (1)
- aliphatic halogenated hydrocarbons (1)
- alkaloid (1)
- all-ceramic (1)
- alleles (1)
- allergen immunotherapy (1)
- allergic rhinitis (1)
- allergy (1)
- alloHSCT (1)
- allocation (1)
- allogeneic (1)
- allogeneic hematopoietic stem cell transplantation (1)
- allogeneic hematopoietic stem cell transplantation (aHSCT) (1)
- allogeneic transplantation (1)
- allosteric inhibition (1)
- allosteric regulation (1)
- alpha band (1)
- alpha peak (1)
- alpha-synuclein (1)
- alpharetroviral vector (1)
- alpinia zerumbet (1)
- alternative 3′ end processing (1)
- alternative oxidase (1)
- alveolar macrophages (1)
- alzheimer disease (1)
- ambiguity (1)
- amblyopia (1)
- ameloblastoma (1)
- amino acid PET (1)
- amino acids (1)
- amlexanox (1)
- amoeboid (1)
- amoxicillin/metronidazole (1)
- amphiregulin (1)
- amygdala (1)
- amyloid beta-peptides (1)
- amyotrophic lateral sclerosis (ALS) (1)
- anaesthesia in orthopaedics (1)
- anaesthetics (1)
- anal carcinoma (1)
- analgesia based sedation (1)
- anaphylactic reactions (1)
- anaplastic large cell lymphoma (1)
- anastomotic leakage (1)
- anatomy (1)
- anatomy and histology (1)
- anemia (1)
- anesthesiology (1)
- angio-immunogenic switch (1)
- angiography (1)
- angioplasty (1)
- angiopoietin-2 (1)
- angiopoietin-like 3 (ANGPTL3) (1)
- angiopoietins (1)
- angiostasis (1)
- animal host (1)
- animal model (1)
- anisotropy (1)
- annual bleeding rate (1)
- anorexia nervosa (1)
- anoxygenic phototrophic sulfur bacteria (1)
- antenatal characteristics (1)
- antenatalne značilnosti (1)
- anterior chamber depth changes (1)
- anti-GD2 immunotherapy (1)
- anti-cancer therapy (1)
- anti-chronic myeloid leukemia (1)
- anti-citrullinated protein antibodies (1)
- anti-diabetes (1)
- anti-epileptic drug (1)
- anti-inflammatory (1)
- anti-inflammatory agents (1)
- anti-inflammatory effects (1)
- anti-retroviral agents (1)
- anti-skin aging (1)
- anti-tumor activity (1)
- antibiotic (1)
- antibiotic treatment (1)
- antibody (1)
- antibody tests (1)
- anticancer agents (1)
- anticholinergic burden (1)
- anticoagulants (1)
- anticoagulation (1)
- anticonvulsant (1)
- anticonvulsant activity (1)
- antidepressants (1)
- antiepileptic drug (1)
- antifibrotic therapy (1)
- antifungal activity (1)
- antifungal combination therapy (1)
- antifungal host response (1)
- antifungal management (1)
- antifungal prophylaxis (1)
- antifungal therapy (1)
- antigen (1)
- antigenic variation (1)
- antigens of infectious origin (1)
- antihormone therapy (1)
- antimicrobial activity (1)
- antioxidant (1)
- antioxidant activity (1)
- antioxidant defense (1)
- antiproliferative activity (1)
- antireflux surgery (1)
- antiresorptive agents (1)
- antiseizure (1)
- antisense oligonucleotides (1)
- antisynthetase antibodies (1)
- antisynthetase syndrome (1)
- antitumor immunity (1)
- antiviral drugs (1)
- antiviral peptide (1)
- anxiety (1)
- apical junction (1)
- apigenin (1)
- apixaban (1)
- apparent diffusion constant (1)
- apparent motion (1)
- apps (1)
- aprotinin (1)
- aptamer (1)
- aquaporin 1 (1)
- aquaporin-4 (AQP4) antibody (1)
- arachidonate 15-lipoxygenase (1)
- arachidonic acid (1)
- archaea (1)
- archaeosomes (1)
- architecture (1)
- arm (1)
- aromatics (1)
- arsenic trioxide (1)
- arterial hypertension (1)
- artery (1)
- artesunate (ART) (1)
- articulatory motor cortex (1)
- artificial neural networks (1)
- aspirin (1)
- assay development (1)
- assessment (1)
- associative memory (1)
- asthma phenotypes (1)
- astrocyte (1)
- astrocyte heterogeneity (1)
- astroglia (1)
- asymmetric hearing (1)
- asymptomatic (1)
- ataxia score (1)
- athletes (1)
- athletic training (1)
- atopy (1)
- atrial septostomy (1)
- atrophy (1)
- attachment loss (1)
- attention deficit hyperactivity disorder (1)
- attention modulation (1)
- attention-deficit/hyperactivity disorder (1)
- attention-deficit/hyperactivitydisorder (1)
- attractiveness (1)
- auditory cortex (1)
- auditory development (1)
- auditory language processing (1)
- auditory prediction (1)
- auditory system (1)
- augmentation materials (1)
- authentication (1)
- authorship (1)
- autism (1)
- autistic disorder (1)
- auto-structure (1)
- autoantibodies (1)
- autoantigen (1)
- autograft (1)
- autoimmune encephalomyelitis (1)
- autoimmune polyglandular syndrome type 2 (1)
- autoimmune thyroiditis (1)
- automated patch-clamp (1)
- automatic environmental tobacco smoke emitter (1)
- automation (1)
- autophagic cell death (1)
- autopsy (1)
- autoreactivity (1)
- autovaccine (1)
- avelumab (1)
- aviscumine (1)
- axon (1)
- azaindole (1)
- b-cell lymphomas (1)
- back pain (1)
- back scan (1)
- bacteria (1)
- bacterial translocation (1)
- bacterium (1)
- baicalein (1)
- balanced state (1)
- balloon pulmonary angioplasty (1)
- baroreflex (1)
- barriers to implementation (1)
- basal cell carcinoma (1)
- basal insulin (1)
- basic leucine zipper transcription factor ATF-like (1)
- basic mechanisms (1)
- basonuclin 2 (1)
- beads (1)
- beam quality correction factors (1)
- behavioral adverse events (1)
- behavioral performance (1)
- belimumab (1)
- bendamustine (1)
- berotralstat (1)
- beta band (1)
- beta blockade (1)
- betamethasone dipropionate (1)
- beta‐trace protein (1)
- bibliometric analysis (1)
- bicuspid aortic valve (1)
- biglycan (1)
- bile duct stenosis (1)
- biliary cirrhosis (1)
- binary search procedure (1)
- binaural cochlear implants (1)
- binding (1)
- bio imaging (1)
- bio-absorbable mesh (1)
- bioacoustics (1)
- bioactive phospholipids (1)
- bioactive phytochemicals (1)
- bioactivity (1)
- biobank (1)
- biochanin A (1)
- biochemical recurrence (1)
- biochemistry (1)
- bioenergetics (1)
- biofilm (1)
- biokompatibilni materijali (1)
- biological maturation (1)
- biological mesh (1)
- biological transport (1)
- biological treatments (1)
- biologically inspired computing (1)
- biologicals (1)
- bioluminescence (1)
- biomarker study (1)
- biomechanics (1)
- biopsy naïve (1)
- bipolar disorders (1)
- birch pollen allergoid (1)
- bistable (1)
- bladder cancer (1)
- bladder cancer (BCa) (1)
- bladder dose (1)
- bladder exstrophy-epispadias complex (1)
- blastic plasmacytoid dendritic cell neoplasm (1)
- blended learning (1)
- bleomycin (1)
- blood consumption (1)
- blood donor (1)
- blood flow recovery (1)
- blood hiv rna (1)
- blood loss (1)
- blood safety (1)
- blood transfusion (1)
- blood-brain barrier (1)
- blood-cerebrospinal fluid barrier (1)
- blow flies (1)
- blow fly (1)
- bmal1 (1)
- body dysmorphic disorder (1)
- body plethysmography (1)
- body posture (1)
- bone (1)
- bone chips (1)
- bone damage (1)
- bone loss (1)
- bone marrow (1)
- bone marrow derived mononuclear cells (1)
- bone marrow metastasis (1)
- bone marrow microenvironment (1)
- bone marrow mononuclear cells (1)
- bone metastasis (1)
- bone morphogenetic protein-2 (1)
- bone morphogenetic proteins (BMPs) (1)
- bone regeneration (1)
- bone substitute material (1)
- bone substitutes (1)
- bone tissue regeneration (1)
- bone-marrow (1)
- bone‐screw (1)
- bone–implant interface (1)
- borrelia mayonii (1)
- bortezomib (1)
- bottom-up (1)
- brachytherapy imaging methods (1)
- brain anatomy (1)
- brain function (1)
- brain injury (1)
- brain metastasis (1)
- brain networks (1)
- brain oscillations (1)
- brain phosphorylome (1)
- brain structure (1)
- brain tumor (1)
- brainmass (1)
- brainsize (1)
- branched-chain amino acids (BCAA) (1)
- breakpoint cluster region (1)
- breast cancer diagnosis (1)
- breast cancer systemic therapy (1)
- breast cancer treatment (1)
- breech (1)
- broad-range qPCR (1)
- broadly neutralizing antibodies (1)
- bronchial allergen challenge (1)
- bronchial allergen provocation (1)
- bronchiolitis obliterans syndrome (1)
- bronchodilator (1)
- buccal mucosa (1)
- buccal mucosal graft urethroplasty (1)
- bulimia nervosa (1)
- bullying (1)
- bundle (1)
- butyrylcholinesterase (1)
- c-kit (1)
- c1orf124 (1)
- cBioPortal (1)
- cFLIP (1)
- cGAS-STING (1)
- cHL (1)
- cIAP1 (1)
- cIAP1 BIR (1)
- cIAP1/2 (1)
- cadherin (1)
- calbindin (1)
- calcification score (1)
- calcipotriol (1)
- calcium handling (1)
- calcium-independent phospholipase A2β (1)
- calcium-sensor (1)
- callous-unemotional traits (1)
- caloric restriction (1)
- calprotectin (1)
- calretinin-knock out (1)
- cancer and drug vulnerabilities (1)
- cancer care (1)
- cancer care providers (1)
- cancer cell malignancy (1)
- cancer cell metabolism (1)
- cancer cells (1)
- cancer drug (1)
- cancer immunobiology (1)
- cancer patients (1)
- cancer screening (1)
- cancer therapy (1)
- cancer-associated fibroblasts (1)
- cancer-specific survival (1)
- candidate genes (1)
- candidemia (1)
- cannabidiol (1)
- cannabinoid receptor type 1 (1)
- cannabinoids (1)
- cannabis (1)
- canonical (1)
- canonical/non-canonical (1)
- cap-dependent translation (1)
- car indoor (1)
- carbapenem resistance (1)
- carbapenem-resistant Gram-negative bacteria (CRGN) (1)
- carbon oxides (COx) (1)
- carbon tetrachloride (1)
- carboxyfluorescein (1)
- carcinoma (1)
- cardiac I/R injury (1)
- cardiac arrest (1)
- cardiac events (1)
- cardiac ischaemia‐reperfusion (1)
- cardiac magnetic (1)
- cardiac myocytes (1)
- cardiac rehabilitation (1)
- cardiomegaly (1)
- cardiomyopathy (1)
- cardiovascular diseases (1)
- cardiovascular magnetic resonance (1)
- cardiovascular pharmacology (1)
- cardiovascular precision medicine (1)
- cardiovascular risk factors (1)
- career promotion (1)
- caregivers (1)
- carnitine supplementation (1)
- carotid (1)
- carpal tunnel syndrome (1)
- carrion (1)
- cartilage oligomeric matrix protein (1)
- cartilage trauma (1)
- case reports (1)
- case study (1)
- case-control study (1)
- caspase 8 (1)
- caspase-1 (1)
- cataract surgery (1)
- catheter (1)
- catheter removal (1)
- catheterization/diagnostic interventional (1)
- causality assessment (1)
- cd4 count determination procedure (1)
- cdk (1)
- cdk2/cyclin A (1)
- ceRNA (1)
- celery (1)
- celiac desease (1)
- cell adhesion (1)
- cell and focal adhesion (1)
- cell cycle (1)
- cell cycle arrest (1)
- cell cycling (1)
- cell fate (1)
- cell fusion (1)
- cell growth (1)
- cell identity (1)
- cell line (1)
- cell salvage (1)
- cell signaling (1)
- cell survival (1)
- cell survival mechanisms (1)
- cell transplantation (1)
- cellular immunology (1)
- cellular reaction (1)
- cellular response (1)
- cellular signalling (1)
- cellular therapy (1)
- centenarians (1)
- central nervous system (1)
- central nervous system infection (1)
- centrifugation (1)
- ceramide synthase (CERS2/CERS1) (1)
- cerclage (1)
- cerebellar mutism (1)
- cerebello-dentato-thalamo-cortical pathway (1)
- cerebral infarct (1)
- cerebral radiation necrosis (1)
- cerebrovascular disease (1)
- ceritinib (1)
- cervical shortening (1)
- cervical spine (1)
- cervico-thoracic junction (1)
- cetuximab-bevacizumab therapy sequence (1)
- ch14.18/CHO (1)
- chamomile (1)
- changes immune activation (1)
- chaperones (1)
- characterization (1)
- charged particles (1)
- checklist (1)
- checkpoint inhibition (1)
- checkpoint proteins (1)
- chelation therapy (1)
- chemical-induced proximity (1)
- chemoattractant (1)
- chemoconvulsant (1)
- chemoembolization (1)
- chemogenomic set (1)
- chemokine (1)
- chemokine receptor 4 (1)
- chemokine receptors (1)
- chemokines: CYP2D6 model (1)
- chemoprevention (1)
- chemosensory cells (1)
- chemotaxis (1)
- chemotherapeutic drug resistance (1)
- chemotherapeutics (1)
- chemotherapeutics-treated (1)
- chemotherapy regimen (1)
- chemotherapy-resistance (1)
- chest injury (1)
- child abuse and neglect (1)
- child maltreatment (1)
- child psychiatry (1)
- childhood (1)
- childhood abuse (1)
- childhood cancer (1)
- children and adolescents (1)
- chimeric antigen receptor t-cell therapy (1)
- chimeric antigen receptors (1)
- chinese medicine (1)
- chloroplasts (1)
- cholangiocarcinoma (1)
- cholecystectomy (1)
- cholestasis (1)
- cholinesterase (1)
- chondrocyte (1)
- chondrocytes (1)
- chromatin immunoprecipitation (1)
- chromosomal breaks (1)
- chromosomal instability (1)
- chromosomal integration (1)
- chromosomal translocations (1)
- chromosome alignment (1)
- chromosome instability (1)
- chromosome segregation (1)
- chronic care (1)
- chronic colitis (1)
- chronic coronary artery disease (1)
- chronic granulomatous disease (1)
- chronic hepatitis C (1)
- chronic illness (1)
- chronic infection (1)
- chronic inflammation (1)
- chronic kidney disease (CKD) (1)
- chronic liver disease (1)
- chronic liver disease (CLD) (1)
- chronic metabolic acidosis (1)
- chronic myeloid leukemia (CML) (1)
- chronic total occlusion (1)
- chronic viral hepatitis (1)
- chronische Niereninsuffizienz (1)
- chronische metabolische Azidose (1)
- chronobiology (1)
- chronotype (1)
- cigarette smoke (1)
- cigarette strength (1)
- cigarettes (1)
- cigarillos (1)
- cilia (1)
- circadian variation (1)
- circular RNA (1)
- circulating miRNA (1)
- circulation (1)
- cisplatin sensitivity (1)
- citizen science (1)
- claims data (1)
- classical conditioning (1)
- classification of bone defects (1)
- clean room (1)
- clear or almost clear skin (1)
- clinical (1)
- clinical cases (1)
- clinical competency (1)
- clinical features (1)
- clinical history (1)
- clinical immunology (1)
- clinical management (1)
- clinical pathways (1)
- clinical practice (1)
- clinical relevance (1)
- clinical tool (1)
- clinical trials (1)
- clinically important restrictions and symptoms (1)
- clinico-biological indices (1)
- cloacae (1)
- cloacal malformation (1)
- clonal dominance (1)
- clonal hematopoiesis (1)
- clopidogrel (1)
- cluster of differentiation 4 (CD4) (1)
- cluster-randomized controlled trial (1)
- clusteranalysis (1)
- co-crystallization (1)
- co-infection (1)
- coaching (1)
- coauthor ship (1)
- cocaine (1)
- coffee (1)
- cognitive control (1)
- cognitive decline (1)
- cognitive deficits (1)
- cognitive fluency (1)
- cognitive functions (1)
- cognitive models (1)
- cognitive states (1)
- cognitively stimulating leisure activities (1)
- cohlear implant (1)
- cohort study (1)
- cold induced pain (1)
- cold tolerance (1)
- colitis (1)
- collaborative feedback (1)
- collagen I (1)
- collagen VI (1)
- collagen adhesion (1)
- collagen degradation marker (1)
- collagen type I (1)
- collagen-based biomaterial (1)
- collagen-based matrix (1)
- collateral growth (1)
- collateral sprouting (1)
- collective dynamics (1)
- colloid (1)
- colon (1)
- colon cancer cells (1)
- colon carcinoma (1)
- colonization (1)
- colorectal cancer (CRC) (1)
- colorectal cancer liver metastases (CRLM) (1)
- column chromatography (1)
- combination (1)
- combination immunotherapy (1)
- combination therapies (1)
- combination treatment (1)
- combined immunodeficiency (1)
- common genetic variation (1)
- common neighbor (1)
- common variant (1)
- common variants (1)
- communication/social competencies (1)
- community violence exposure (1)
- comorbidities (1)
- comorbidity (1)
- compaction (1)
- comparative pathology (1)
- comparative study (1)
- competitive peptide (1)
- complement dependent cytotoxicity (1)
- complement; patients (1)
- complementary information (1)
- complementary psychosocial care (1)
- complex I deficiency (1)
- complex systems (1)
- complexity theory (1)
- complexome profiling (1)
- comprehensive care (1)
- computational biology (1)
- computational functional genomics (1)
- computational intelligence (1)
- computational modeling (1)
- computational models (1)
- computational neuroimaging (1)
- computational neuroscience (1)
- computational techniques (1)
- computer tomography (1)
- computer vision (1)
- computer-assisted (1)
- computer-assisted drug therapy (1)
- computerized programs (1)
- concentric (1)
- concordance (1)
- concurrent (1)
- concurrent TMS--fMRI (1)
- conditioning (1)
- conduit (1)
- cone-beam computed tomography (CBCT) (1)
- cone-beam computer tomography (1)
- confidence (1)
- confinement (1)
- congenic mice (1)
- congenital deafness (1)
- congruency (1)
- connectional fingerprint (1)
- connective tissue (1)
- connective tissue graft (1)
- conotoxin (1)
- consciousness (1)
- consensus (1)
- consolidation treatment (1)
- contact heat evoked potentials (CHEPS) (1)
- contact lens solution (1)
- continuing education (1)
- continuing medical education (1)
- continuous glucose monitoring (1)
- contralateral delay activity (1)
- controlled nuclear import (1)
- conventional laparoscopic (1)
- conventional/traditional transarterial chemoembolization (cTACE) (1)
- conversation skills (1)
- convolution neural network (1)
- convulsive seizures (1)
- cooling deactivation (1)
- cooling period (1)
- coordination (1)
- copeptin (1)
- coping (1)
- copy number polymorphism (1)
- cord clamping (1)
- corneas (1)
- corona virus (1)
- coronary (1)
- coronary artery bypass surgery (1)
- coronary calcium (1)
- coronary computed-tomography angiography (CCTA) (1)
- coronary disease (1)
- coronary plaques (1)
- coronavirus disease 2019 (1)
- corpus callosum (1)
- correction of incidence rate (1)
- correction of mortality rate (1)
- correlation (1)
- corrosion (1)
- cortex, gray matter (1)
- cortical folding (1)
- cortical layers and areas (1)
- cortical malformation (1)
- cortical network (1)
- cortical networks (1)
- cortical slices (1)
- cortical thickness (1)
- corticomuscular coherence (CMC) (1)
- cost-effective (1)
- cost-of-illness (1)
- costimulation (1)
- costs (1)
- coupling (1)
- courting behavior (1)
- cranberry (1)
- crestal bone loss (1)
- crime scene (1)
- crista junction (1)
- cristae (1)
- critical care unit (1)
- critical ill patients (1)
- critical periods (1)
- critical size defect (1)
- critically ill patients (1)
- cross-border (1)
- cross-communication (1)
- cross-modal (1)
- cross-modal plasticity (1)
- cross-sectional study (1)
- crowns (1)
- cryogenic electron microscopy (1)
- cryopreservation (1)
- cryotherapy (1)
- crystalloid (1)
- cultural and social transformation of sexuality (1)
- cumulative dose (1)
- curriculum (1)
- cutaneous T cell lymphoma (1)
- cuticular hydrocarbons (1)
- cyclic depsipeptide (1)
- cyclin D1 (1)
- cyclins (1)
- cyclooxygenase 1 (COX-1) (1)
- cyclooxygenase 2 (COX-2) (1)
- cyclophilin A (1)
- cyclophosphamide (1)
- cyclosporine (1)
- cys-loop receptor (1)
- cystatin C (1)
- cytarabin (1)
- cytarabine dose (1)
- cytokine (1)
- cytokine gene expression (1)
- cytokine release syndrome (1)
- cytokine, angiogenesis (1)
- cytoskeleton (1)
- cytotoxic immunotherapy (1)
- dNTP pools (1)
- dabigatran (1)
- daily activity protocols (1)
- damage associated molecular pattern (1)
- damage-associated molecular pattern (1)
- dapagliflozin (1)
- data modeling (1)
- data quality (1)
- data quality check (1)
- day clinic (1)
- deaf white cat (1)
- death (1)
- death receptor (1)
- debridement (1)
- decision aids (1)
- decision support systems (1)
- decision-making (1)
- declaration of tobacco ingredients (1)
- decomposition (1)
- deconvolution (1)
- decorin (1)
- decorrelation (1)
- dedifferentiation (1)
- deep mutational scanning (1)
- deep neural network (1)
- deep sedation (1)
- defect configuration (1)
- delay (1)
- delayed auditory feedback (1)
- delayed cholecystectomy (1)
- delayed wound healing (1)
- deletion 5q (1)
- delirium (1)
- delta-9-tetrahydrocannabinol (1)
- dendrite (1)
- dendritic cell–tumor cell fusion (1)
- dendritic inhibition (1)
- denervation (1)
- density equalizing mapping (1)
- dental abutment (1)
- dental assistant (1)
- dental emergency treatment (1)
- dental health professional (1)
- dentin adhesives (1)
- dentistry (1)
- dentoalveolar surgery (1)
- depolymerization (1)
- depressive symptoms (1)
- depressive symptoms clusters (1)
- deprivation (1)
- dermatology (1)
- dermatomes (1)
- desensitization (1)
- desmoplastic small round cell tumor (1)
- desmoplastic stroma (1)
- deswelling (1)
- deubiquitinating enzyme (1)
- deubiquitinating enzymes (1)
- devastated bladder outlet (1)
- device handling (1)
- dexamethasone (1)
- diabetes therapy (1)
- diabetic macular edema (1)
- diabetic nephropathy (1)
- diabetic neuropathy (1)
- diagnostic algorithm (1)
- diagnostic biomarkers (1)
- diagnostic method (1)
- diagnostic test (1)
- diagnostics (1)
- dialysis (1)
- diarrhoeal disease (1)
- diastolic function (1)
- diclofenac (1)
- diet (1)
- differentiated thyroid carcinoma (1)
- diffuse large B cell lymphoma (1)
- diffuse low-grade glioma (1)
- diffusion MRI (1)
- diffusion microstructure (1)
- diffusion tensor imaging (DTI) (1)
- digestive tract (1)
- digital age determination (1)
- digital didactics (1)
- digital pathology (1)
- digitale Didaktik (1)
- dihydroceramides (1)
- dimethylfumarate (1)
- dipeptide (1)
- diplopia (1)
- direct antiviral (1)
- direct antiviral agents (1)
- direct-acting antivirals (DAAs) (1)
- directed disulfide bond formation (1)
- directed forgetting (1)
- directly acting antiviral agents (1)
- disasters (1)
- discoidin domain-containing receptor (1)
- discomfort/pain (1)
- discontinuous dose dependency (1)
- disease modelling (1)
- disease progression (1)
- disease-free survival (1)
- disease-modifying antirheumatic drugs (1)
- disease-modifying therapy (1)
- dislocation (1)
- disposable insulin pens (1)
- disruptive behaviour disorder (1)
- dissemination (1)
- dissimilatory sulfite reductase (1)
- distal pronephric outlet obstruction (1)
- distance learning (1)
- distraction (1)
- distributed computation (1)
- diuretics (1)
- diurnal (1)
- docetaxel (1)
- docking studies (1)
- dog study (1)
- donor deferral (1)
- donor recruitment (1)
- donor retention (1)
- dopamine (1)
- doppler (1)
- dorsal auditory stream (1)
- dose response curve (1)
- dosimetry (1)
- dosing accuracy (1)
- double inversion recovery (DIR) (1)
- double orifice mitral valve (1)
- doublecortin (1)
- doxycycline (1)
- drilling tool design (1)
- drug delivery (1)
- drug hepatotoxicity (1)
- drug interaction (1)
- drug metabolism and distribution (1)
- drug resistance and invasiveness (1)
- drug screening (1)
- drug targets (1)
- drug therapy (1)
- drug-coated balloon (1)
- drug-eluting balloon (1)
- drug-eluting beads TACE (DEB-TACE) (1)
- drug-induced liver injury (DILI) (1)
- druggable genome (1)
- drugs (1)
- drug‐resistant epilepsy (1)
- dsr genes (1)
- dual antiplatelet therapy (1)
- dual bronchodilators (1)
- dynamic 18F-FDG PET/CT (1)
- dynamic connectivity (1)
- dynamic stimuli (1)
- dysbiosis (1)
- dysferlin (1)
- dysferlinopathy (1)
- dyssynchrony analysis (1)
- e-Health (1)
- e-scooter (1)
- eNOS (1)
- eNPP2 (1)
- ePTFE membrane (1)
- early cholecystectomy (1)
- early continence (1)
- early epilepsy (1)
- early infection (1)
- early loss (1)
- early myocardial damage (EMD) (1)
- early recognition (1)
- early tumor stages (1)
- eating disorders (1)
- eccentric (1)
- economic burden (1)
- economy (1)
- ectopic pregnancy (1)
- edema (1)
- editorials (1)
- edoxaban (1)
- educational cases (1)
- educational measurement (1)
- educational settings (1)
- educational technology (1)
- educational theory (1)
- effect mechanism (1)
- effective lens position (1)
- effectiveness (1)
- eight disorders (1)
- ejection fraction (EF) (1)
- electric and acustic stymulation (1)
- electric scooter (1)
- electrical stimulation (1)
- electroconvulsive therapy (1)
- electroencephalography (EEG), EEG reference choices, event-related potentials (ERP), independent component analysis (ICA), pain research, contact heat evoked potentials (CHEPS) (1)
- electromagnetic navigation bronchoscopy (EMN, ENB) (1)
- electrophiles (1)
- elite athlete (1)
- eltrombopag (1)
- embodiment (1)
- embolization (1)
- emergence (1)
- emergency care (1)
- emergent self-organizing maps (1)
- emotion (1)
- emotional climate (1)
- emotional information processing (1)
- empagliflozin (1)
- empowerment (1)
- emulsion diffusion (1)
- encoding strategies (1)
- end of life care (1)
- endocarditis (1)
- endogenous clock (1)
- endometrial cancer (1)
- endometriosis (1)
- endophytes (1)
- endoscopic retrograde cholangiopancreatography (1)
- endoscopy (1)
- endothelial activation (1)
- endothelial barrier (1)
- endothelial function (1)
- endothelial nitric-oxide synthase (1)
- endothelial receptor expression (1)
- endothelial to mesenchymal transition (1)
- endothelin (1)
- endothelin receptor type A antagonist (1)
- endothelium (1)
- endotoxemia (1)
- endotoxins (1)
- enforced viral replication (1)
- english (1)
- enterovirus (1)
- entomological evidence (1)
- envelope technique (1)
- environment (1)
- eosinophil cationic protein (1)
- eosinophilic cholangitis (1)
- eosinophils (1)
- epidemics (1)
- epidermal growth factor (1)
- epidermal growth factor receptor (1)
- epidermis (1)
- epididymitis (1)
- epigenetic memory (1)
- epigenome (1)
- epigenomics (1)
- epileptic encephalopathies (1)
- epileptic encephalopathy (1)
- epiregulin (1)
- epithelial cells (1)
- epithelial mesenchymal transition (1)
- epithelial‐mesenchymal transition (1)
- epitope mapping (1)
- erectile dysfunction (1)
- ergometry (1)
- ergonomics (1)
- erosions (1)
- erythropoietin (1)
- erythropoietin (EPO) (1)
- escape mutations (1)
- esterification (1)
- ethical trade-off (1)
- ethyl pyruvate (1)
- eutheria (1)
- euthymic (1)
- evaluation practice (1)
- event logs (1)
- event-based (1)
- event-related potential (1)
- event-related potentials (ERP) (1)
- evoked response (1)
- evolution (1)
- ex vivo expansion (1)
- ex vivo model (1)
- ex vivo stimulation (1)
- ex-Gaussian analysis (1)
- examination success (1)
- excess fluid volume (1)
- excitability (1)
- executive control (1)
- executive function (1)
- exercise on prescription (1)
- exercise physiology (1)
- exercise testing (1)
- exercise training (1)
- exome sequencing (1)
- experimental human pain models (1)
- expert review (1)
- explainable AI (1)
- exponential model (1)
- exposure (1)
- expressed emotion (1)
- expression studies (1)
- extensive surgery (1)
- extensively drug-resistant (1)
- external fixation (1)
- external joint moments (1)
- extracellular chromatin (1)
- extracellular vesicles (1)
- extracting solvents (1)
- extraction socket healing (1)
- extremity (1)
- eye movement (1)
- eye tracking (1)
- eye-tracking (1)
- face (1)
- face inversion effect (1)
- face-name association task (1)
- facial EMG (1)
- facial emotion recognition (1)
- facial expressions of emotion (1)
- facial muscle activity (1)
- facial nerve functional outcome (1)
- facial prosthesis (1)
- factor IX (1)
- factor VIII (1)
- factor VIII (FVIII) (1)
- falls (1)
- false memory (1)
- familial colorectal cancer (1)
- familial infantile epilepsy (1)
- familiengerechte Hochschule (1)
- family medicine (1)
- family-friendly universities (1)
- fat (1)
- fatty acid elongase (Elovl1/4/5) (1)
- fatty acids (1)
- fear conditioning (1)
- fear extinction (1)
- fear generalization (1)
- fear learning (1)
- feeder cells (1)
- feeding (1)
- female health (1)
- female subjects (1)
- femoropopliteal segment (1)
- ferret (1)
- ferric carboxymaltose (1)
- fetal weight estimation (1)
- fiber orientations (1)
- fibre tracking (1)
- fibrin (1)
- fibrinolysis (1)
- fibroblast (1)
- fibrocytes (1)
- fibrogenesis (1)
- fibromodulin (1)
- fibronectin (1)
- fibrosarcoma (1)
- fibrotest (1)
- fidaxomicin (1)
- finger tapping (1)
- fingolimod (1)
- first-line chemotherapy (1)
- fitness (1)
- fixation (1)
- fixed partial dentures (1)
- fizička aktivnost; (1)
- flavivirus entry factor (1)
- fluid (1)
- fluid shear stress (1)
- fluocinolone acetonide (1)
- fluorescent dye (1)
- fluorine (1)
- focal adhesion kinase (1)
- focal cortical dysplasia (FCD) (1)
- focal seizures (1)
- focal therapy (1)
- follow-up (1)
- forensics (1)
- formalin-fixed and paraffin-embedded tissue (FFPE) (1)
- formalin-fixed paraffin-embedded (FFPE) samples (1)
- fourth (1)
- fractional anisotropy (1)
- free gingival graft (1)
- free leptin index (FLI) (1)
- freeze avoidance (1)
- fresh frozen plasma (1)
- frontal cortex (1)
- frontotemporal lobar degeneration (1)
- full-contour crown restorations (1)
- full-contour zirconia (1)
- fully human (1)
- fumonisin B1 (1)
- function, sorting (1)
- functional MRI (1)
- functional imaging (1)
- functional magnetic resonance imaging (fMRI) (1)
- fundoplication (1)
- fungal pathogens (1)
- fungi (1)
- fungus (1)
- funktionelle Bildgebung (1)
- furcation involvement (1)
- further education (1)
- fusion (1)
- gRNA library (1)
- gadobutrol (1)
- gadolinium (1)
- gadolinium enhancing lesion (1)
- gadolinium‐based contrast agent (1)
- galactomannan (1)
- gallbladder cancer (1)
- gallbladder cancer xenografts (1)
- gallstone disease (1)
- galunisertib monohydrate (LY2157299) (1)
- gap junction protein alpha 4-genotype (1)
- gas chromatography-mass spectrometry (1)
- gastric (1)
- gastric surgery (1)
- gastro-oesophageal junction cancer (1)
- gastroesophageal reflux (1)
- gastrointestinal tract (1)
- gel spacer injection (1)
- gender difference (1)
- gender dysphoria (1)
- gender equality (1)
- gender equality plan (1)
- gender studies (1)
- gender-affirming hormone therapy (1)
- gene delivery (1)
- gene expression analysis (1)
- gene expression profiling (1)
- gene expression profiling (GEP) (1)
- gene signature (1)
- gene vectors (1)
- general anaesthesia (1)
- general practitioner (1)
- generic preparedness (1)
- genes (1)
- genetic diversity (1)
- genetic generalized epilepsy (1)
- genetic markers (1)
- genetic phenotypes (1)
- genetic polymorphisms (1)
- genetic predisposition (1)
- genetic rearrangements (1)
- genetics and genomics (1)
- gene×environment interactions (1)
- genome (1)
- genome editing (1)
- genome-wide (1)
- genome-wide association study (1)
- genomic classifiers (1)
- genotype (1)
- genotype determination (1)
- geriatric medicine (1)
- germ cell tumors (1)
- germinal center (1)
- gland extracts (1)
- glecaprevir (1)
- glial activation (1)
- glial fibrillary acidic protein (1)
- glioblastoma (GBM) (1)
- glioblastoma stem-like cells (1)
- glioma-associated oncogene homolog (1)
- gliomas (1)
- gliomatosis cerebri growth pattern (1)
- global diversity (1)
- global mapping (1)
- global warming (1)
- glucocorticoid (1)
- glucocorticoids (1)
- glucosamine (1)
- glucose (1)
- glutamate metabolism (1)
- glutamine (1)
- glycation (1)
- glycolysis (1)
- glycosaminoglycan (1)
- gold nanoparticles (1)
- good manufacturing practice (1)
- gossypol (1)
- governance (1)
- graft (1)
- graft perfusion (1)
- graft rejection (1)
- graft-versus host (1)
- graft-versus-host disease (1)
- graft-versus-tumor effect (1)
- gram-negative bacteria (1)
- granulocyte (1)
- granulocytecolony stimulating factor (1)
- granulocytemacrophage colony-stimulating factor (1)
- granuloma (1)
- granulomas (1)
- granulomatous inflammation (1)
- gray matter (1)
- gray matter changes (1)
- gray‐white matter blurring (1)
- green fluorescent protein (1)
- green tea extract (1)
- grey matter volume (1)
- grinding (1)
- grounded theory (1)
- growth hormone (1)
- guanidine alkaloid (1)
- guessing likelihood (1)
- guidance (1)
- guinea pig (1)
- gut microbiota (1)
- gyrification (1)
- h-index (1)
- hMOF/KAT8 (1)
- habituation (1)
- haematologic malignancies (1)
- haemophilia (1)
- haemophilia A (1)
- haemophilic arthropathy (1)
- haemostasis (1)
- hair cell (1)
- hand area (1)
- hanging donors (1)
- haplo-identical (1)
- haploidentical (1)
- harassment (1)
- harmine (1)
- head and neck neoplasms (1)
- head and neck squamous cell carcinoma (1)
- head to head (1)
- head zones (1)
- head-and-neck cancer (1)
- head-to-head (1)
- headache (1)
- health apps (1)
- health care (1)
- health care personnel (1)
- health economics (1)
- health insurance data (1)
- health literacy (1)
- health related quality of life (1)
- health services accessibility (1)
- health services research (1)
- healthcare (1)
- healthcare personnel (1)
- healthcare professional (1)
- healthcare systems (1)
- healthcare worker (1)
- healthcare workers (1)
- healthy subjects (1)
- health‐related quality of life (1)
- hearing loss (1)
- hearing nerve (1)
- heart (1)
- heart rate variability (1)
- heat (1)
- heat stress (1)
- hedgehog (1)
- hedgehog signaling pathway (1)
- helminths (1)
- hemadsorption (1)
- hemagglutination (1)
- hematoma (1)
- hematopoietic cell transplantation (1)
- hematopoietic cells (1)
- hematopoietic stem cell mobilization (1)
- hematopoietic stress (1)
- hemiplegic migraine (1)
- hemispherotomy (1)
- hemodynamic (1)
- hemodynamic instability (1)
- hemophilia A (1)
- hemorrhage (1)
- hemorrhagic transformation (1)
- hepatic fibrosis (1)
- hepatic osteodystrophy (1)
- hepatic phenotype (1)
- hepatic steatosis (1)
- hepatic tumor (1)
- hepatitis B virus (1)
- hepatitis E (1)
- hepatitis E virus (1)
- hepatitis c (1)
- hepatoblastoma (1)
- hepatocellular carcinoma (HCC) (1)
- hepatocyte transplantation (1)
- hepatocytes (1)
- hepatotoxicity (1)
- herb induced liver injury (HILI) (1)
- herbal drug (1)
- herbs (1)
- hereditary angioedema, (1)
- hereditary tumor syndromes (1)
- hernia to the cord (1)
- herpes simplex virus (1)
- heterogeneity of plasticity effects (1)
- hexosamine biosynthetic pathway (1)
- hiPSC (1)
- hierarchy (1)
- high molecular weight plasticizer (1)
- high surgical risk (1)
- high throughput (1)
- high-dimensional data sets (1)
- high-dose chemotherapy (1)
- high-dose-rate interstitial brachytherapy (1)
- high-energy photon and proton radiation (1)
- high-intensity focused ultrasound ablation (1)
- high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (1)
- high-pitch (1)
- high-throughput nucleotide sequencing (1)
- high-throughput sequencing (1)
- higher education (1)
- higher education pedagogy (1)
- highly parallel recordings (1)
- high‐mobility group box‐1 (HMGB1) (1)
- hip joint (1)
- hippocampal neuronal cell line (1)
- hippocampal sclerosis (1)
- hippocampal volume (1)
- histamine (1)
- histological technic (1)
- histomorphometry (1)
- histone deacetylase (1)
- histone deacetylase 5 (1)
- histone deacetylases (HDACs) (1)
- histone modification (1)
- histoplasmosis (1)
- history (1)
- history of medicine (1)
- history taking (1)
- hiv (1)
- home care services (1)
- home visit (1)
- homeostatic synaptic scaling (1)
- homing (1)
- homoarginine (1)
- homologna transplantacija (1)
- hormonal therapy (1)
- hormone (1)
- hormones (1)
- hospital (1)
- hospital exemption (1)
- hospitalization (1)
- host cell interaction (1)
- host cell response (1)
- host immune response (1)
- host response (1)
- host-directed therapies (1)
- host-pathogen interaction (1)
- host-targeting antivirals (1)
- hostpathogen interaction (1)
- hotspot loci (1)
- house dust mite allergy (1)
- household chaos (1)
- huCAR19 (1)
- human Natural Killer cell (1)
- human antigen R (HuR) (1)
- human brain (1)
- human decellularized dermis (1)
- human erythroid leukemia (HEL) (1)
- human experimental pain (1)
- human genomics (1)
- human gingival fibroblasts (1)
- human immunodeficiency virus (1)
- human intracranial recordings (1)
- human knockout model (1)
- human lymph node (1)
- human natural killer cell (1)
- human papilloma virus (1)
- human renal proximal tubular epithelial cells (1)
- human resources (1)
- human sera (1)
- human skin graft (1)
- humanized mice (1)
- humanized mouse (1)
- humanized mouse model (1)
- humans (1)
- humectant agents (1)
- humoral factors (1)
- hybrid (1)
- hydrocephalus (1)
- hydroxyapatite crystals (1)
- hydroxyurea (1)
- hygienic hand disinfection (1)
- hygienische Händedesinfektion (1)
- hymenoptera (1)
- hyperalgesia (1)
- hyperammonemia (1)
- hyperarousal (1)
- hyperbaric oxygen treatment (1)
- hyperlipidemia (1)
- hypertension (1)
- hypertension and anti-hypertensive treatment (1)
- hypertension, pulmonary (1)
- hypertonic (1)
- hypoglycaemia (1)
- hyponatremia (1)
- hypoparathyroidism (1)
- hypophosphataemia (1)
- hypothalamus (1)
- hypothermia (1)
- hypoxia-induced cell death (1)
- hypoxia-inducible factor (1)
- hysteresis (1)
- i-AAA protease (1)
- iCBT (1)
- iCLIP (1)
- iDrug induced liver injury (1)
- idiopathic dystonia (1)
- idiopathic pulmonary fibrosis (1)
- idiosyncratic DILI (1)
- idiosyncratic drug-induced liver injury (1)
- ifenprodil (1)
- ignition (1)
- illness experiences (1)
- image analysis (1)
- image distortion (1)
- image-based risk modelling (1)
- imiquimod (1)
- imitation (1)
- immune (1)
- immune checkpoint inhibitors (1)
- immune deficiency (1)
- immune dysregulation (1)
- immune function (1)
- immune landscape (1)
- immune microenvironment (1)
- immune modulation (1)
- immune responses (1)
- immune surveillance of cancer (1)
- immune therapy (1)
- immune tolerance (1)
- immune-checkpoint inhibition (1)
- immune-mediated inflammatory diseases (1)
- immune-modulating therapy (1)
- immunization (1)
- immunocompromised patient (1)
- immunoglobulin superfamily (1)
- immunologic (1)
- immunological research (1)
- immunology and infectious diseases (1)
- immunomagnetic (1)
- immunoprecipitation (1)
- immunostaining (1)
- immunosuppressants (1)
- immunosuppression (1)
- immunosuppressive agent (1)
- immunosuppressive drug (1)
- impact factor (1)
- implant (1)
- implant movement (1)
- implant stability (1)
- implant survival (1)
- implanto-prosthetic therapy (1)
- imported malaria (1)
- improvement in quality of life (1)
- in silico simulation (1)
- in situ gene correction (1)
- in situ hybridization (1)
- in situ vaccine (1)
- in vivo micro‐CT (1)
- in vivo model of critical size defects (1)
- in-cabin exposure (1)
- incisional hernia (1)
- indacaterol/glycopyrronium (1)
- independent component analysis (ICA) (1)
- indication (1)
- individual moulds (1)
- individualized solutions (1)
- individualized therapy (1)
- indomethacin (1)
- indoor air pollution (1)
- inducible gene expression (1)
- inducible nitric oxide synthase (1)
- induction chemotherapy (1)
- infant (1)
- infants (1)
- infection eradication (1)
- infection model (1)
- infections: pneumonia, TB, viral (1)
- infectious disease (1)
- infectious diseases (1)
- infectivity (1)
- inflammatory arthritis (1)
- inflammatory cytokines (1)
- inflammatory markers (1)
- influenza (1)
- influenza pandemic (1)
- influenza vaccination (1)
- influenza vaccine (1)
- infomax (1)
- information decomposition (1)
- information needs (1)
- information storage (1)
- information transfer (1)
- inhalation flow profiles (1)
- inhaled steroids (1)
- inhaler (1)
- inheritance (1)
- inhibition (1)
- inhibition of DNA-binding (1)
- inhibitor of apoptosis protein family (1)
- inhibitors (1)
- injury (1)
- innate and adaptive immune response (1)
- innate immune system (1)
- innate lymphoid cells (1)
- inner ear therapy (1)
- inpatient hospital admissions (1)
- insect herbivory (1)
- insecticide (1)
- insertable cardiac monitor (1)
- insertion (1)
- insomnia (1)
- instructional interventions (1)
- insulitis (1)
- integrate and fire (1)
- integrated stress response (1)
- intensive care (1)
- intensive care unit (1)
- inter-assay precision (1)
- interactome (1)
- interaural time difference (1)
- interference (1)
- interferon regulatory factor 9 (IRF9) (1)
- interferon-free (1)
- interferon-free antiviral treatment (1)
- interferon-γ (1)
- interferons (1)
- interleukin-1 (1)
- interleukin-10 (1)
- interleukin-1β (1)
- interleukin-23 receptor (1)
- interleukin-6 (1)
- internal ribosomal entry site (IRES) (1)
- internal time (1)
- international (1)
- internet (1)
- internet- and mobile-based intervention (1)
- internet-based cognitive behavioral therapy (1)
- internet-based treatment (1)
- interneurons (1)
- interscalene brachial plexus block (1)
- interstitial brachytherapy (1)
- interstitial lung disease (1)
- intervention (1)
- intervention study (1)
- interventional radiology (1)
- intervertebral disc (1)
- intervertebral disc (IVD) (1)
- intervertebral disc degeneration (1)
- intestinal barrier (1)
- intestinal graft-versushost disease (1)
- intestinal obstruction (1)
- intoxication (1)
- intra-arterial chemotherapy (1)
- intraarterial therapy (1)
- intracellular trafficking (1)
- intracerebral haemorrhage (1)
- intracerebral hemorrhage (1)
- intracranial hemorrhage (1)
- intraperitoneal therapy (1)
- intratumoral (1)
- intraventricular chemotherapy (1)
- intravital microscopy (1)
- intrinsic DILI (1)
- intrinsic apoptosis (1)
- intrinsic drug resistance (1)
- intronic ORF (1)
- invasive growth (1)
- invasive mold infection (1)
- inverse dynamics (1)
- involuntary hospitalization (1)
- in vivo (1)
- ion channel (1)
- ionomycin (1)
- ionotropic glutamate receptors (1)
- irbesartan (1)
- irinotecan-loaded drug-eluting beads TACE (DEBIRI-TACE) (1)
- iron chelation (1)
- iron chelator (1)
- iron chelators (1)
- iron deficiency (1)
- iron homeostasis (1)
- iron metabolism (1)
- iron overload versus deprivation (1)
- iron supplements (1)
- irritable bowel syndrome (1)
- ischaemia (1)
- ischemia (1)
- ischemic stroke (1)
- ischemic type biliary lesions (1)
- isocaloric ketogenic diet (1)
- isogenic (1)
- isomeric antagonists (1)
- isovaleric acidaemia (1)
- isradipine (1)
- isušenje (1)
- itraconazole (1)
- ixekizumab (1)
- joint bleeding (1)
- joint contact forces (1)
- joint loading (1)
- joint moments (1)
- junctional adhesion molecule (1)
- juvenile brain lesion (1)
- juvenile myoclonic epilepsy (1)
- kallikrein inhibitor (1)
- kavalactones (1)
- keratinized mucosa (1)
- keratinocytes (1)
- keratoplasty (1)
- ketamine (1)
- ketogenic (1)
- ketogenic diet (1)
- ketone body (1)
- kidney disease (1)
- kidney formation (1)
- kidney function (1)
- kinesin (1)
- kinetic fingerprint (1)
- klinische Kompetenz (1)
- klinische Studie (1)
- knee joint (1)
- knockout mice (1)
- knockout mouse (1)
- kommunikative/soziale Kompetenzen (1)
- konduit (1)
- koroner arter baypas cerrahisi (1)
- kutane Larva migrans (1)
- kynureninase (1)
- kynurenine (1)
- kyphosis (1)
- l-DOPA (1)
- laceration (1)
- lacosamide (1)
- lactate (1)
- lactate dehydrogenase (1)
- laminin (1)
- laminins (1)
- lamotrigine (1)
- language (1)
- laser (1)
- laser based cell manipulation (1)
- laser microdissection (1)
- laser-capture microdissection (1)
- late lumen loss (1)
- late-life depression (1)
- latent class analysis (1)
- latent tuberculosis infection (1)
- layer 1 (1)
- layer-specificity (1)
- learning (1)
- learning curve (1)
- learning strategies (1)
- left ventricular function (1)
- left ventricular non-compaction (1)
- left ventricular trabeculation (1)
- leg alignment (1)
- legal gender reassignment (1)
- lenalidomide (1)
- length of study (1)
- lentiviral vector (1)
- leptin (1)
- leptin, leptin receptor (sOB-R) (1)
- leptomeningeal disease (1)
- leptomeningeal metastases (1)
- lethal toxin (1)
- leukapheresis (1)
- leukemia initiating cell (1)
- leukemia; solid tumors (1)
- leukocytosis (1)
- leukodystrophy (1)
- leukotriene (1)
- life cycle (1)
- life span (1)
- lifelong learning (1)
- lifespan (1)
- ligelizumab (1)
- light microscopy (1)
- light transmission aggregometry (1)
- limb girdle muscular dystrophy type 2B (LGMD2B) (1)
- liminality (1)
- linoleic acid metabolites (1)
- lipid mediator (1)
- lipid metabolism (1)
- lipid raft (1)
- lipid signaling (1)
- lipid signalling (1)
- lipid-protein interaction (1)
- lipidomic analysis (1)
- lipidomics (1)
- lipids (1)
- lipids inflammatory pain (1)
- lipiodol (1)
- lipopolyplex (1)
- lipopolysaccharide (1)
- liposomes (1)
- liquid PRF (1)
- liquid-PRF (1)
- live cell imaging (1)
- liver abscess (1)
- liver adaption (1)
- liver cancer (1)
- liver cell lines (1)
- liver damage (1)
- liver diseases (1)
- liver immunology (1)
- liver metabolism (1)
- liver transplantation center (1)
- livermetastases of colorectal cancer (1)
- living will (1)
- local anesthetic (1)
- local field potential (1)
- local inflammation (1)
- local radiotherapy (1)
- lockdown (1)
- locomotor rhythm (1)
- locoregional chemotherapy (1)
- long essay questions (1)
- long essey questions (1)
- long non-coding RNA (1)
- long noncoding RNAs (1)
- long reads (1)
- long-acting muscarinic antagonist (1)
- long-acting β2-agonists (1)
- long-term depression (1)
- long-term distress (1)
- long-term follow-up (1)
- long-term infection (1)
- long-term infusion (1)
- long-term outcome (1)
- long-term potentiation (1)
- longitudinal follow-up after epilepsy surgery (1)
- longitudinal relaxation time T1 (1)
- longitudinally extensive transverse myelitis (1)
- loss (1)
- loss of signal (1)
- low birth weight infant (1)
- low doses (1)
- low speed centrifugation concept (1)
- low-back pain (1)
- low-cost medication (1)
- low-density lipoprotein cholesterol (1)
- low-dose imaging (1)
- low-dose radiation therapy (1)
- low-risk (1)
- lower extremity arterial disease (1)
- lower urinary tract obstruction (1)
- lumican (1)
- lung (1)
- lung disease (1)
- lung disease phenotype (1)
- lung remodeling (1)
- lung transplantation (1)
- luteolin (1)
- lymph nodes (1)
- lymphangiogenesis (1)
- lymphocyte (1)
- lymphocytes (1)
- lymphoma pathogenesis (1)
- lysosomes (1)
- l‐arginine:glycine amidinotransferase (1)
- mGluR3 (1)
- mGluR5 (1)
- mPGES-1 (1)
- mRNA (1)
- mRNA active cancer immunotherapy (1)
- mRNA and protein expression (1)
- mRNA decay (1)
- mRNA export (1)
- mRNA stability (1)
- mRNA vaccine (1)
- mTOR inhibition (1)
- mTOR inhibitor (1)
- mTOR inhibitors (1)
- mTORC (1)
- macula (1)
- macular hole (1)
- magentoencephalography (MEG) (1)
- magnetic field gradient (1)
- magnetic resonance imaging of the brain (1)
- magnetoencephalography (MEG) (1)
- maintenance therapy (1)
- major adverse cardiac events (1)
- major adverse cardiovascular events (1)
- major depression (1)
- major depression (MD) (1)
- major depressive disorder (1)
- major depressive disorder (MDD) (1)
- malaria elimination (1)
- malignancy (1)
- malignant glioma (1)
- mammals (1)
- mammary cancer (1)
- mammary carcinoma (1)
- mammary carcinomas (1)
- mandatory reporting system (1)
- mantle cell lymphoma (1)
- marathon (1)
- maraton (1)
- markovianity (1)
- maspin (1)
- mass spectrometry-based proteomics (1)
- massive parallel sequencing (1)
- massive weight loss (1)
- maternal care (1)
- maternal tobacco smoke (1)
- matrikine (1)
- matrix metalloproteinase (1)
- matrix metalloproteinases (1)
- maturation (1)
- mature T-cell lymphoma (1)
- mean diffusivity (1)
- measure development/validation (1)
- mechanical stimuli (1)
- mechanism of action (1)
- mechanistic target of rapamycin (mTOR) (1)
- mechanobactericidal surfaces (1)
- medial prefrontal cortex (1)
- medial thigh lift (1)
- medical and health research (1)
- medical error (1)
- medical history (1)
- medical illustration (1)
- medical informatics initiative (1)
- medical psychologoy (1)
- medical school (1)
- medical studies admission (1)
- medical teacher (1)
- medical teaching (1)
- medication (1)
- medication reconciliation (1)
- medication review (1)
- medications (1)
- medulloblastoma (1)
- medulloblastoma resection (1)
- memantine (1)
- membrane (1)
- membrane potential (1)
- membrane protein (1)
- membrane protein complex (1)
- membrane repair (1)
- membrane structure (1)
- memebrane (1)
- memory and learning tests (1)
- memory performance (1)
- mental health (1)
- mental health services (1)
- menthol (1)
- mentoring (1)
- men’s (1)
- merkel cell carcinoma (1)
- mesenchymal (1)
- mesenchymal stem cell (1)
- mesenchymal stromal cell (1)
- meta-analysis (1)
- metabolic cancer therapy (1)
- metabolic reprogramming (1)
- metabolic syndromes (1)
- metabolites (1)
- metalloprotease (1)
- metamorphosis (1)
- metaplasticity (1)
- metastability (1)
- metastasis-directed radiotherapy (1)
- metastates (1)
- metastatic cancer (1)
- metastatic colorectal cancer (1)
- metastatic melanoma stage IV (1)
- metastatic urethral cancer (1)
- meter (1)
- methotrexate (1)
- methylation profiling (1)
- methylglyoxal (1)
- methyltransferases (1)
- miR (1)
- miR-122 (1)
- miR-143-3p (1)
- miR-181 (1)
- miR-21 (1)
- miR-375 (1)
- miRNA let-7e (1)
- miRNA-17–92 (1)
- micelles (1)
- micro CT (1)
- microRNAs (1)
- microcirculation (1)
- microdeletions (1)
- microkeratome (1)
- microlesions (1)
- microplasmin (1)
- microsaccades (1)
- microsatellite instability (1)
- microsomal ethanol-oxidizing system (MEOS) (1)
- microsurgical treatment (1)
- microtubular cytoskeleton (1)
- microtubule disruptors (1)
- microtubule dynamics (1)
- microtubule-targeting agents (1)
- microwave breast imaging (1)
- midkine (1)
- migrants (1)
- migration and invasion (1)
- mindfulness (1)
- mini gastric bypass (1)
- minimal clinically important difference (1)
- minimally invasive cardiac surgery (1)
- mino acid metabolism (first pass) (1)
- mir-148a (1)
- mismatch repair (1)
- mitochondrial bioenergetics and glycolysis (1)
- mitochondrial dynamics (1)
- mitochondrial dysfunction (1)
- mitogen-activated protein kinase (1)
- mitogenic effects (1)
- mitomycin C (1)
- mitostatin (1)
- mitotic arrest (1)
- mitotic kinases (1)
- mixed micelles (1)
- mobile air quality study (1)
- mobile phone apps (1)
- mobile tongue cancer (1)
- mobilization (1)
- model curriculum (1)
- model psychosis (1)
- moisturing cream (1)
- molecular characteristics (1)
- molecular diagnosis (1)
- molecular diagnostics (1)
- molecular dynamics (1)
- molecular dynamics simulation (1)
- molecular identification (1)
- molecular marker (1)
- molecular pathology (1)
- molecular targeted drugs (1)
- molecular targeting (1)
- molecular therapy (1)
- molecular tumor board (1)
- molecular typing (1)
- momilactone A (1)
- momilactone B (1)
- monitoring (1)
- monkey (1)
- monkeys (1)
- monoamine oxidase A (1)
- monoclonal antibody (1)
- monocrotaline (1)
- monocyte chemotactic protein 1 (MCP-1) (1)
- monogenic disorders (1)
- mononuclear cell (1)
- montelukast (1)
- morbidity (1)
- morphological filtering (1)
- morphometry (1)
- motifs (1)
- motion analysis (1)
- motion capture (1)
- motor control (1)
- motor cortex (1)
- motor neuron disease (1)
- motor task (1)
- motor-evoked potential (1)
- mountain (1)
- mouse models (1)
- movement disorders (1)
- movement pattern (1)
- movement profile (1)
- mpMRI (1)
- mtor (1)
- mucormycete (1)
- mucormycetes (1)
- mucosal inflammation (1)
- mucositis (1)
- multi-drug resistance (1)
- multidisciplinary pain treatment (1)
- multidrug-resistant Gram-negative bacteria (MRGN) (1)
- multifocal (1)
- multimedia (1)
- multimodal complex treatment (1)
- multimorbidity [MeSH] (1)
- multiple choice question (1)
- multiple choice questions (1)
- multiple chronic conditions (1)
- multiple myeloma (1)
- multiple trauma (1)
- multiplex immunofluorescence (1)
- multiresistente Gram-negativen Stäbchenbakterien (MRGN) (1)
- multisensory (1)
- multisensory integration (1)
- multisite cooperation (1)
- multiunit activity (1)
- murine model (1)
- muscle (1)
- muscle disease (1)
- muscular dystrophies (1)
- muscular dystrophy (1)
- musculoskeletal modeling (1)
- musculoskeletal pain (1)
- musician (1)
- mutated neoantigens (1)
- mutational antigenic profiling (1)
- mutations (1)
- mutually exclusive mutations (1)
- mycophenolate mofetil [MMF] (1)
- myeloid cells (1)
- myeloperoxidase (1)
- myocardial infarction (1)
- myocardial injury (1)
- myocardial perfusion (1)
- myocarditis (1)
- myocardium (1)
- myocyte enhancer factor 2 (1)
- myoferlin (1)
- myogenic tone (1)
- myogenic vasoconstriction (1)
- myositis (1)
- myotonia congenita (1)
- nadomjesci za kost (1)
- nadp (1)
- naked haplo (1)
- nanobodies (1)
- nanoparticle (1)
- nanostructures (1)
- narrative content analysis (1)
- narrative economics (1)
- narrative medicine (1)
- natriuretic peptide (1)
- natural compounds (1)
- natural cytotoxicity (1)
- natural killer T cells (1)
- natural killer cell cultivation (1)
- natural killer cell cytotoxicity (1)
- natural killer cell expansion (1)
- natural killer cell therapy (1)
- natural sciences (1)
- naturalistic sample (1)
- necrosis (1)
- needle displacement (1)
- needs assessment (1)
- negative symptoms (1)
- neglect (1)
- negligencia (1)
- nematophin (1)
- neoadjuvant treatment (1)
- neocortex development (1)
- neocortical circuits (1)
- neoepitopes (1)
- neonatal intensive care unit (1)
- neonatal septic shock (1)
- neonates (1)
- neonatology (1)
- neosexual revolution (1)
- neosexualities (1)
- neovascularization, physiologic (1)
- nerve growth factor (NGF) (1)
- nerve injury (1)
- nerve-sparing (1)
- network (1)
- network neuroscience (1)
- network topology (1)
- networks (1)
- neural adaptation (1)
- neural computation (1)
- neural development (1)
- neural dynamics (1)
- neural systems (1)
- neurale Stammzellen (1)
- neuraminidase inhibitor (1)
- neuro-ophthalmological examination (1)
- neurobiology (1)
- neuroblastoma regression (1)
- neurocognition (1)
- neurodegenerative diseases (1)
- neurodevelopmental (1)
- neurodevelopmental disorders (1)
- neuroendocrine (1)
- neurofibrillary pathology (1)
- neuroinflammation (1)
- neuroinformatics (1)
- neurological diseases (1)
- neurological emergencies (1)
- neurological impairment (1)
- neurological outcome (1)
- neuronal avalanches (1)
- neuronal maturation (1)
- neuronale Netzwerke (1)
- neuronale Vorläuferzellen (1)
- neurons (1)
- neurooncology (1)
- neuropathological diagnosis (1)
- neuropathy (1)
- neuropilin-1 (1)
- neuroprotection (1)
- neuropsychiatric disorders (1)
- neuropsychological impairment (1)
- neuropsychology (1)
- neurosurgery (1)
- neurotrophins (1)
- neurovascular bundle preservation (1)
- neutral ceramidase (Asah2) (1)
- neutral sphingomyelinase (Smpd3) (1)
- neutralization (1)
- neutralizing antibodies (1)
- neutropenia (1)
- new miRNA functions (1)
- newborn infant (1)
- newborn screening (1)
- next-generation sequencing (1)
- nicotinic acetylcholine receptors (1)
- nintedanib (1)
- nitro-fatty acids (1)
- nitrogen dioxide (1)
- nitrogen oxides (NOx) (1)
- niños (1)
- nocardia (1)
- nocardiosis (1)
- nociception (1)
- nodular lymphocyte predominant Hodgkin lymphoma (1)
- nodular sclerosis (1)
- noise intervention measures (1)
- non - pharmacological anti-infective measures (1)
- non-Poissonian (1)
- non-ST-segment elevation acute coronary syndrome (1)
- non-canonical (1)
- non-classical adhesion molecule (1)
- non-communicable disease (1)
- non-communicable diseases (1)
- non-homologous end joining (1)
- non-invasive brain stimulation (1)
- non-invasive fibrosis assessment (1)
- non-linear dynamics (1)
- non-malignant hematological diseases (1)
- non-receptor tyrosine kinase (nRTK) (1)
- non-sensory bias (1)
- non-sexual (1)
- non-small cell lung cancer (1)
- non-small-cell lung cancer (1)
- non-spatial processing (1)
- nonalcoholic fatty liver disease (1)
- nonalcoholic steatohepatitis (1)
- noncoding RNA (1)
- noninterventional (1)
- nonnucleoside polymerase inhibitor (1)
- nonrandom connectivity (1)
- nonviral gene delivery (1)
- non‐selective beta‐blocker (1)
- non‑Hodgkin's lymphoma (1)
- novel H1N1 influenza (1)
- novel psychoactive substance (1)
- nuclear envelope (1)
- nuclear hormone receptor (1)
- nuclear import (1)
- nuclear pore complex (1)
- nuclear translocation (1)
- nucleotide analogue (1)
- nucleotide metabolism (1)
- nucleus accumbens (1)
- nursery school students (1)
- nursery students (1)
- nurses (1)
- nutrient deprivation (1)
- obese (1)
- objecitvity (1)
- object perception (1)
- object tracking (1)
- observational cohort study (1)
- occupational factors (1)
- occupational stress (1)
- ocriplasmin (1)
- off-pump surgery (1)
- offene Fragen (1)
- offset times (1)
- oksidacioni stres (1)
- older patients (1)
- older people (1)
- oligodendrocyte (1)
- oligomerization (1)
- olivo-ponto-cerebellar atrophy (OPCA) (1)
- omalizumab (1)
- omphalocele (1)
- oncogenes (1)
- oncological gastrectomy (1)
- oncological outcome (1)
- oncolytic virotherapy (1)
- oncomodulation (1)
- one anastomosis gastric bypass (1)
- one health (1)
- online information processing (1)
- online learning (1)
- online reasoning patterns (1)
- online survey (1)
- online teaching (1)
- open-source (1)
- operative (1)
- optical coherence tomography (1)
- optical imaging (1)
- oral and maxillofacial surgery (1)
- oral anticoagulation (1)
- oral cancer (1)
- oral enzyme combination (1)
- oral kallikrein inhibitor (1)
- oral squamous cell carcinoma (1)
- organ dysfunction (1)
- organ failure (1)
- organ of Corti (1)
- organisation of health services (1)
- organizational development (1)
- organophosphate flame retardants (OFR) (1)
- organotypic slice cultures (1)
- orientation (1)
- orientation selectivity (1)
- orthodeoxia (1)
- orthodontic mini‐implant (1)
- orthodontist (1)
- orthopaedic surgery (1)
- orthopic liver transplantation (1)
- oscillation (1)
- oscillator (1)
- oseltamivir (1)
- osteogenic sarcoma cells (1)
- osteoimmunological changes (1)
- osteopenia (1)
- osteoporosis treatment (1)
- osteotomy (1)
- ostium (1)
- otoferlin (1)
- ouabain (1)
- outcome parameter (1)
- oval split ring resonator (1)
- ovary (1)
- overall survival (OS) (1)
- overreaching markers (1)
- own-face perception (1)
- oxLDL (1)
- oxidised lipids (1)
- oxygen (1)
- oxygen metabolism (1)
- p14 (1)
- p16 (1)
- p21 phosphorylation (1)
- p21 stability (1)
- p21-activated kinase 2 (1)
- p22phox (1)
- p38 (1)
- p44/42 MAPK (1)
- p53 activator (1)
- p62 (1)
- p67phox (1)
- p73 (1)
- p75 (1)
- p97 (1)
- pCREB (1)
- pSMAD2 (1)
- pacemaker implantation (1)
- pack-years (PY) (1)
- paclitaxel sensitization (1)
- paediatric (1)
- paediatric nephrology (1)
- pain genetics (1)
- pain management (1)
- pain medication (1)
- pain questionnaire (1)
- pain research (1)
- pain target (1)
- pain, dorsal root ganglia (1)
- paired continuous theta burst stimulation (1)
- palbociclib (1)
- palmitoylation (1)
- pancreatic surgery (1)
- pandemic preparedness (1)
- papilloma (1)
- parameter estimation (1)
- parasite identity (1)
- parathormone (PTH) (1)
- parenting (1)
- parenting students (1)
- paricalcitol (1)
- parietal cortex (1)
- parkinson’s disease (1)
- parsley (1)
- participation (1)
- particle size distribution (1)
- particulate matter (PM) (1)
- passive immunization (1)
- passive reading paradigm (1)
- passive smoke (1)
- patency (1)
- patent (1)
- patent foramen ovale (1)
- pathogenesis (1)
- pathology (1)
- patient and public involvement (1)
- patient centered care (1)
- patient perspective (1)
- patient preference (1)
- patient preferences (1)
- patient questionnaire (1)
- patient study (1)
- patient-derived xenograft (1)
- patient-reported outcome measure (1)
- patient-reported outcomes (1)
- patients (1)
- patients' experience (1)
- patient‐centred outcomes (1)
- patient’s desires (1)
- patient’s perspective (1)
- pattern (1)
- patterns of progression (1)
- paxilline (1)
- pazopanib (1)
- peanut allergy (1)
- pediatric (1)
- pediatric cancer (1)
- pediatric epilepsy (1)
- pediatric eye screening (1)
- pediatric patients (1)
- pediatrics (1)
- pedicle screws (1)
- peficitinib (1)
- peg-interferon lambda (1)
- peginterferon (1)
- peginterferon-α (1)
- pelvic injury (1)
- pelvic ring fracture (1)
- pentafluorothio group (1)
- pentose phosphate pathway (1)
- perceptual memory (1)
- perceptual organization (1)
- perforin (1)
- performance assessment (1)
- performance evaluation (1)
- performance-based funding allocation (1)
- perfusion-weighted imaging (1)
- peri-implantitis (1)
- pericardial empyema (1)
- pericarditis (1)
- pericytes (1)
- perinasal skin cancer (1)
- perinatal HIV infection (1)
- perineurium (1)
- perio-prosthetic joint infection (1)
- periodontal disease progression (1)
- periodontal diseases (1)
- periodontal probing, (1)
- periodontal risk assessment (1)
- periodontal risk calculator (1)
- perioperative ischemia (1)
- perioperative mortality (1)
- perioperative outcome (1)
- perioperative period (1)
- peripheral arterial disease (1)
- peripheral blood mononuclear cells (1)
- peripheral blood stem cell transplant (1)
- peripheral nerve (1)
- peripheral vascular diseases (1)
- perirenal (1)
- peritoneal carcinomatosis (1)
- peri‐implant lesions (1)
- peri‐implant probing (1)
- peri‐implantitis therapy (1)
- persistent atrial fibrillation (1)
- persisting pain (1)
- person-oriented approach (1)
- personalised therapy (1)
- personalized oncology (1)
- pertuzumab (1)
- pervasive developmental disorders (1)
- pessary (1)
- pet rabbit (1)
- phage (1)
- phage display (1)
- phage therapy (1)
- phagocytes (1)
- pharmacist (1)
- pharmacoepidemiology (1)
- pharmacogenetics (1)
- pharmacogenomics (1)
- pharmacologic vitreolysis (1)
- pharmacology (1)
- phase 2 clinical trials (1)
- phase 3 study (1)
- phase II trial (1)
- phase III (1)
- phase coupling (1)
- phase-1 (1)
- phenolics (1)
- phenotype (1)
- phenotype/genotype relation (1)
- phenotypic screening (1)
- phenotypic spectrum (1)
- phenylephrine (1)
- phonological processing (1)
- phosphatases (1)
- phosphatidylinositols (1)
- phosphorus (1)
- phosphorylation (1)
- photoaging (1)
- photodynamic therapy (1)
- phylogenetic analysis (1)
- physical activity counseling (1)
- physical activity promotion (1)
- physical activity recommendations (1)
- physiotherapy (1)
- pibrentasvir (1)
- pictilisib (1)
- pig (1)
- pigs (1)
- pilot study (1)
- pineal (1)
- piperidone (1)
- pirinixic acid (1)
- pirinixic acid derivative (1)
- pitch perception (1)
- pivalate (1)
- pivoloyl (1)
- pixantrone (1)
- placement (1)
- plant growth (1)
- plant resistance (1)
- plant-insect interactions (1)
- plaque psoriasis (1)
- plasma membrane MICA (1)
- plasma-derived factor VIII concentrate, prophylaxis (1)
- plasminogen (1)
- plastic (1)
- platelet (1)
- platelet aggregation (1)
- platelet count (1)
- platelet lysate (1)
- platelet rich plasma (1)
- platform switching (1)
- platform-switched (1)
- platypnea (1)
- pleiotropin (1)
- pleomorphic xanthoastrocytoma (1)
- pleuropericarditis (1)
- plus-tip (1)
- pneumocystis carinii (1)
- pneumocystis pneumonia (1)
- pneumonia (1)
- podocytes (1)
- poetry (1)
- point shear wave elastography (1)
- pol g (1)
- polarization (1)
- polishing (1)
- pollen allergy (1)
- polo-like kinase (1)
- polo-like kinase 3 (1)
- poly(I:C) (1)
- poly-L-lysine (1)
- polyamines/metabolism (1)
- polycyclic aromatic hydrocarbon (1)
- polycystic kidney (1)
- polydipsia (1)
- polyethylenimine (1)
- polylactic acid (PLA) (1)
- polylactide (1)
- polyomavirus (1)
- polyomavirus (MCPyV) (1)
- polypharmacology (1)
- polyphenols (1)
- polysomnography (1)
- polysorbate 20 (1)
- polyuria (1)
- poor condition subarachnoid hemorrhage (1)
- popliteal artery (1)
- population-based (1)
- population-based surveillance (1)
- porcine (1)
- portosystemic shunt (1)
- posaconazole (1)
- post hoc study (1)
- post-liver transplantation management (1)
- post-translational modifications (PTMs) (1)
- post-transplantation lymphoproliferative disease (1)
- post-traumatic (1)
- post-traumatic osteoarthritis (1)
- posterior fossa masses (1)
- posterior parietal cortex (1)
- posterior vitreous detachment (1)
- postmortem interval (1)
- postnatal neurogenesis (1)
- postoperative delirium (1)
- posttranslational modification (1)
- posttransnational modification (1)
- posttraumatic inflammation (1)
- post‐traumatic stress disorder (1)
- potassium channels (1)
- power dynamics (1)
- ppi1 (1)
- practical exercises (1)
- pranlukast (1)
- pre-clinical models (1)
- pre-emptive allogeneic hematopoietic stem cell transplantation (1)
- pre-school asthma (1)
- preclinical (1)
- preclinical semesters (1)
- preconditioning (1)
- prediabetes (1)
- predialysis (1)
- prediction model (1)
- predictive biomarkers (1)
- predictive timing (1)
- predictive validity (1)
- pregnant (1)
- premature infant (1)
- premature transcript termination (1)
- premotor cortex (1)
- preoperative anaemia management (1)
- preoperative assessment (1)
- preoperative preparation (1)
- preparation (1)
- preprocedure prophylaxis (1)
- preschool asthma (1)
- preschool children (1)
- preschool health examination (1)
- presenilin (PS)/gamma-secretase activity (1)
- pressure (1)
- pressure cycling technology (1)
- pressure ulcer treatment (1)
- pressurized intraperitoneal aerosol chemotherapy (PIPAC) (1)
- preterm (1)
- pretreatment (1)
- prevalence of hysterectomy (1)
- prevent smoking (1)
- preventive medicine (1)
- primary biliary cirrhosis (1)
- primary biliary diseases (1)
- primary brain tumors (1)
- primary healthcare (1)
- primary immunodeficiency (PID) (1)
- primary motor cortex (1)
- primary motor cortex (M1) (1)
- primary mouse proximal tubular cells (1)
- primary prostate cancer (1)
- primary tubular cells (1)
- prior knowledge (1)
- proactive aggression (1)
- proanthocyanidin (1)
- procedural safety (1)
- process mining (1)
- productivity (1)
- progenitor (1)
- progeria (1)
- progesterone (1)
- progestin (1)
- prognosis research (1)
- prognostic biomarker (1)
- prognostic factor (1)
- programmed cell death (1)
- programmed cell death ligand 1 (1)
- programmed cell death protein 1 (1)
- progranulin (1)
- progression-free survival (PFS) (1)
- progressive myoclonus epilepsy (1)
- progressive neoplastic disease (1)
- proinflammatory microenvironment (1)
- promotion index (1)
- pronephric development (1)
- prophylactic vaccine (1)
- propofol anesthesia (1)
- proprotein convertase subtilisin/kexin type 9 inhibition (1)
- prospective memory (1)
- prospective studies (1)
- prostaglandin E2 (1)
- prostate and breast cancer cell lines (1)
- prostate brachytherapy (1)
- prostate cancer cells (1)
- prostate volume (1)
- prostate-specific antigen (1)
- prostatic cancer (1)
- proteases (1)
- protein C (1)
- protein kinase D (1)
- protein kinases (1)
- protein phosphatase 1 (PP1) inhibition/activation (1)
- protein phosphorylation (1)
- protein stability (1)
- protein tagging (1)
- protein transduction (1)
- protein/lentiviral transduction (1)
- protein–protein interactions (1)
- proteoglycans (1)
- proteostasis (1)
- proto-oncogene proteins c-akt (1)
- protocol compliance (1)
- proton density (1)
- proton pump inhibitors (1)
- proximal tubule cells (1)
- pruritus (1)
- pseudoexfoliative syndrome (1)
- psoriatic (1)
- psychiatric disorders (1)
- psychiatry (1)
- psycho-oncology (1)
- psychological (1)
- psychological distress (1)
- psychological model (1)
- psychological questionnaires (1)
- psychometric properties (1)
- psychometrics (1)
- psychosocial adjustment (1)
- psychosocial stress (1)
- psychotherapy (1)
- pteridine (1)
- public health department (1)
- public health. (1)
- public mental health (1)
- publication (1)
- pulmonary arterial hypertension (1)
- pulmonary endarterectomy (1)
- pulmonary inflammation (1)
- pulmonary nocardiosis (1)
- pulse labeling (1)
- pulse-spreading harmonic complex (1)
- pupil dilation (1)
- pupillary reactivity (1)
- putrescine/metabolism (1)
- pyramidal cell (1)
- qPCR (1)
- qRT-PCR (1)
- qRT-PCR detection (1)
- quality control (1)
- quality indicators (1)
- quality management (1)
- quality of care (1)
- quality of health care (1)
- quantification (1)
- quantitative T1 mapping (1)
- quantitative T1‐difference maps (1)
- quantitative mass spectrometry (1)
- quantitative proteomics (1)
- quantitative sensory testing (1)
- quantum biology (1)
- quantum neurobiology (1)
- rRNA (1)
- racket sports (1)
- radiation damage response (1)
- radiation oncology (1)
- radiation theraphy (1)
- radiation therapy (1)
- radiation-induced leukemia (1)
- radical oxygen species (1)
- radical prostatecomy (1)
- radical scavenging chemicals (1)
- radiofrequency (1)
- radiofrequency ablation (1)
- radioimmunotherapy (1)
- radioimmunotherpay (1)
- radiological (1)
- radiomic (1)
- radionuclide imaging (1)
- radioresponse (1)
- radiotherapy resistance (1)
- radixin (1)
- radon therapy (1)
- randomised controlled trial (1)
- randomized (1)
- randomized controlled trial (1)
- rare disease (1)
- rare disesases (1)
- rare variant (1)
- rare variants (1)
- rat femur defect (1)
- rat model (1)
- rct (1)
- re-emerging virus (1)
- re-transplantation (1)
- reactivation (1)
- reactive aggression (1)
- reactive oxygen species (ROS) (1)
- readmission rates (1)
- reaktivne vrste kiseonika (1)
- real-world (1)
- real-world evidence (1)
- receptor (1)
- receptor for advanced glycation end product (RAGE) (1)
- receptor tyrosine kinase (1)
- recertification (1)
- recombinant vesicular stomatitis virus‐Zaire ebolavirus (1)
- recommendation (1)
- recurrence (1)
- recurrent chromosomal translocations (1)
- recurrent laryngeal nerve palsy (1)
- recurrent mutations (1)
- recurrent optic neuritis (1)
- red blood cells (1)
- redox (1)
- redox signalling (1)
- redox-linked proton translocation (1)
- redundancy (1)
- redundant information (1)
- referred pain (1)
- reflexes (1)
- refractory aGvHD (1)
- registry for primary immunodeficiency (1)
- regorafenib (1)
- regorafenib csf concentration (1)
- regulation (1)
- regulatory T cell (1)
- regulatory T cells (1)
- relapsing fever (1)
- relapsing–remitting (1)
- relaxation (1)
- relaxometry (1)
- reliable change index (1)
- remifentanil (1)
- remission (1)
- remote ischemic preconditioning (1)
- remote monitoring (1)
- removal (1)
- renal failure (1)
- renal impairment (1)
- renal ischemia reperfusion injury (1)
- renal tubular cells (1)
- renal tubular epithelial cells (1)
- renin-angiotensin system (1)
- reorganization (1)
- repeat DMEK (1)
- repeat biopsy (1)
- repeated (1)
- reperfusion injury (1)
- repetition suppression (RS) (1)
- repetitive firing (1)
- repetitive transcranial magnetic stimulation (1)
- reproduction biology (1)
- repsonse process patterns (1)
- requirements analysis (1)
- research consortium (1)
- research in academic medicine (1)
- resective surgery (1)
- reserve substance (1)
- reservoir computing (1)
- resilience (1)
- resistance-associated substitutions (RAS) (1)
- resolution (1)
- resonance (1)
- resource utilization (1)
- respiratory complex I (1)
- respiratory disease (1)
- respiratory failure (1)
- restenosis (1)
- resting EEG (1)
- resting-state functional connectivity (1)
- resting‐state (1)
- restless legs syndrome (1)
- restrictive atrial communication (1)
- resuscitation (1)
- resveratrol (1)
- retina (1)
- retinal degeneration (1)
- retinal detachment (1)
- retinoic acid-related orphan receptor gamma t (1)
- retrospective (1)
- retrospective trial (1)
- retuximab (1)
- revalidation (1)
- reverse transcription (1)
- rhabdomyosarcomas (1)
- rheumatoid (1)
- rhodocetin-αβ (1)
- rhyme (1)
- rhythm (1)
- rhythmic aptitude (1)
- rhythms (1)
- ribociclib (1)
- ribosome-inactivating protein (1)
- rice husk (1)
- ridge preservation (1)
- right heart catheter (1)
- right ventricular function (1)
- riociguat (1)
- risk assessment (1)
- risk communication (1)
- risk factor progression (1)
- risk genes (1)
- risk management (1)
- risk score (1)
- rivaroxaban (1)
- robotic heart surgery (1)
- robotik kalp cerrahis (1)
- rolipram (1)
- romske ženske (1)
- root coverage (1)
- rosacea (1)
- rosetting T cells (1)
- roughness (1)
- rub-in technique (1)
- running (1)
- running wheel (1)
- rural health program (1)
- sCD163 (1)
- sCD206 (1)
- sE-cadherin (1)
- saliva (1)
- salvage radiotherapy (1)
- salvage therapy (1)
- sarcoma (1)
- sarcopenia (1)
- scaffold size (1)
- scaffolding proteins (1)
- scavenger receptor (1)
- schizophrenia spectrum (1)
- sciatic nerve (1)
- sciatic nerve injury (1)
- sclerosing cholangitis (1)
- sclerostin (1)
- scoping review (1)
- screening routine (1)
- screening test (1)
- screw augmentation (1)
- screw loosening (1)
- second mitochondria-derived activator of caspases mimetic (1)
- secondary cancer (1)
- secondary data analysis (1)
- secondary hyperparathyroidism (sHPT) (1)
- secondary schools (1)
- seed germination (1)
- segmentation (1)
- selectin (1)
- selection (1)
- selective attention (1)
- selective autophagy (1)
- selective autophagy receptor (1)
- selective mutism, (1)
- self-administration (1)
- self-citation (1)
- self-esteem (1)
- self-management support (1)
- self-organisation (1)
- self-organized criticality (1)
- self-schema (1)
- selfish genetic element (1)
- self‐expanding (1)
- semen (1)
- sensitization (1)
- sensorimotor exercise training (1)
- sensory deprivation (1)
- sensory neurons (1)
- sensory processing (1)
- sequential ALK-inhibitor therapy (1)
- serine palmitoyltransferase 2 (Sptlc2) (1)
- serology (1)
- serositis (1)
- serotonin (1)
- serum (1)
- serum albumin deficiency (1)
- serum concentrations (1)
- severe acute respiratory syndrome coronavirus (1)
- severe asthma (1)
- severe congenital neutropenia (1)
- severe uncontrolled asthma (1)
- severe vitamin D deficiency (1)
- sexual revolution (1)
- sexually transmitted diseases (1)
- sexually transmitted infection (1)
- sex‑determining region Y-box 11 (1)
- sham (1)
- shedding (1)
- shell ginger (1)
- shock (1)
- shock filter (1)
- short linear motifs (SLiMs) (1)
- short tandem repeats (1)
- short-chain ceramide (1)
- short-term prophylaxis (1)
- shortage of family doctors (1)
- shortening of treatment (1)
- shrinkage (1)
- siRNA delivery (1)
- siRNA/RNAi (1)
- sialitis (1)
- sickle cell anemia (1)
- signal transducer and activator of transcription (1)
- signal transducer and activator of transcription 3 (1)
- signal transducer and activator of transcription-1 (1)
- signalosome (1)
- silence interfering RNA (1)
- silicone device (1)
- silk fibroin (1)
- simeprevir (1)
- single best choice question (1)
- single choice questions (1)
- single nucleotide polymorphism (1)
- single-port cholecystectomy (1)
- single‐photon emission (1)
- sinus rhythm (1)
- sirtuin1 (1)
- sirtuins (1)
- six-step technique (1)
- size of cigarettes (1)
- skill mix (1)
- skills shortage (1)
- skin conductance (1)
- skin inflammation (1)
- skin involvement (1)
- sleep apnea (1)
- sleepiness (1)
- slow-wave rhythms (1)
- slowing (1)
- smac mimetic (1)
- small compounds (1)
- small leucine-rich proteoglycan (1)
- small molecule inhibitor (1)
- small molecules (1)
- small-angle neutron scattering (1)
- smoking in pregnancy (1)
- social cognitive (1)
- social determinants (1)
- social isolation (1)
- social psychiatry (1)
- socioeconomic status (1)
- sodium bituminosulfonate (1)
- sodium channels (1)
- sofosbuvir (1)
- soft drinks (1)
- soft skills (1)
- soft tissue sarcoma (STS) (1)
- solid tumors (1)
- solitary pulmonary nodule (1)
- soluble epoxide hydrolase (1)
- soluble tumor necrosis factor receptor (1)
- solvent (1)
- solvent displacement (1)
- somatic mutations (1)
- somatoform disorder (1)
- somatostatin interneurons (1)
- sonic hedgehog (1)
- sonic hedgehog signaling (1)
- sonidegib (1)
- sound analyses (1)
- sound-induced flash illusion (1)
- sox genes (1)
- spatial (1)
- spatial interactions (1)
- spatial processing (1)
- species differences (1)
- spectral activity (1)
- spectrin (1)
- spectroscopy (1)
- speech rhythm (1)
- speech segmentation (1)
- spermidine (1)
- sphinganine 1-phosphate (1)
- sphingolipid metabolism (1)
- sphingolipid sphingosine-1-phosphate (1)
- sphingosine 1-phoshate (1)
- sphingosine 1-phosphate antagonistst/inhibitors (1)
- sphingosine 1-phosphate metabolism (1)
- sphingosine 1-phosphate receptor (1)
- sphingosine 1-phosphate signaling (1)
- sphingosine kinase (1)
- sphingosine kinase 1 (1)
- sphingosine-1-phosphate receptor (1)
- sphingosine-1-phosphate receptor 5 (1)
- spider toxin (1)
- spike train (1)
- spike train analysis (1)
- spike-in SILAC (1)
- spike-timing dependent plasticity (1)
- spike-timing dependent-like plasticity (1)
- spinal fusion (1)
- spindle assembly (1)
- spindle mispositioning (1)
- spine (1)
- spinster homology protein 2 (Spns2) (1)
- spiral ganglion (1)
- spiral ganglion cell (1)
- spiral ganglion cells (1)
- spirochete (1)
- spirometry (1)
- spontaneous portosystemic shunt (1)
- sport (1)
- sports (1)
- squamous cell carcinoma (1)
- squamous cell carcinoma of head and neck (1)
- staff capacity (1)
- staff fluctuation (1)
- stage (1)
- stage II/III colorectal cancer (1)
- standard value (1)
- standardization (1)
- standardized regression-based change norms (1)
- starvation (1)
- state exams (1)
- statedependence (1)
- statistical parametric mapping (1)
- steatosis (1)
- stellate reticulum (1)
- stem cell niche (1)
- stem cell therapy (1)
- stem cells (1)
- stem/progenitor cell expansion (1)
- stenosis (1)
- stenosis quantification (1)
- stent (1)
- stereoselectivity (1)
- stereotactic (1)
- sterile abscess (1)
- sterile α motif (SAM) (1)
- steroid control of aging (1)
- steroid-resistant aGvHD (1)
- sterol regulatory element binding protein-2 (1)
- stimulation (1)
- stimulus coding (1)
- stiripentol (1)
- stopping rule (1)
- stratification (1)
- strength (1)
- strength and conditioning mesocycle (1)
- strength training (1)
- stretching (1)
- stroke prevention (1)
- stromal-derived factor 1 (1)
- structural biology and molecular biophysics (1)
- structural covariance (1)
- structural equation modeling (1)
- structural plasticity (1)
- structure (1)
- structure–activity relationships (1)
- studentisches Lernverhalten (1)
- study protocol (1)
- subcutaneous fat (1)
- subcutaneous immunotherapy (1)
- subject selection (1)
- subjunctivity (1)
- sublingual immunotherapy (1)
- substance abuse disorder (1)
- subventricular zone (1)
- subventricular zone (SVZ) (1)
- success rate (1)
- succession (1)
- suicidality (1)
- suicide (1)
- sulfasalazine (1)
- sulfur dioxide (1)
- sulfur globules (1)
- superficial femoral artery (1)
- superiority (1)
- supervised machine-learning (1)
- supervision (1)
- supervisión (1)
- suplementacija (1)
- supplementary motor area (1)
- supplementary motor area (SMA) (1)
- supplementation (1)
- support vector machines (1)
- suprapubic catheter (1)
- surface marker reversion (1)
- surface-based morphometry (1)
- surfactant (1)
- surgical margin (1)
- surveillance (1)
- survey (1)
- sympathetic nervous system (1)
- sympathicus (1)
- symptoms (1)
- synapse (1)
- synaptic plasticity (1)
- synaptic signaling (1)
- syncope (1)
- synergistic interaction (1)
- synovial fibroblast (1)
- synoviocyte (1)
- synovium (1)
- syntax (1)
- synuclein (1)
- systematic biopsy (1)
- systematisches Review (1)
- systemic antibiotics (1)
- systemic inflammation (1)
- systemic lupus erythematosus (1)
- systemic sclerosis (1)
- szentiamide (1)
- t(6;9) (1)
- t-distributed stochastic neighbor embedding (1)
- tDCS (1)
- tRNA (1)
- tacrolimus (1)
- tailored treatment schedule (1)
- talent development (1)
- talent identification (1)
- tandem mass spectrometry (1)
- target variability (1)
- targeted biopsy (1)
- targeting (1)
- task set (1)
- task-switching training (1)
- tea (1)
- teach-the-teacher (1)
- teacher training (1)
- teacher's training (1)
- teachers' training (1)
- teaching competencies (1)
- teaching skills (1)
- tear (1)
- tehnika dekalcifikacije (1)
- telmisartan (1)
- temporal correlations (1)
- temsirolimus-resistance (1)
- terapia cognitivo conductual enfocada en trauma (1)
- teratoma (1)
- terebridae venom (1)
- terminology (1)
- test protocol (1)
- testicular cancer (1)
- testing (1)
- testis (1)
- testosterone (1)
- tetracycline (1)
- tetraether lipid (1)
- tetrahydrobiopterin (1)
- tetrahydrocannabinol (1)
- thalassemia (1)
- thalidomide (1)
- the allen institute for brain science (1)
- the small molecule inhibitor MRIA9 (1)
- theory of sexuality (1)
- theranostics (1)
- therapeutics (1)
- therapy at the end of life (1)
- thiazolidine and perhydrothiazine derivatives of aldophosphamide and I-aldophosphamide (1)
- thighplasty (1)
- thioredoxin (1)
- thiosulfate oxidation (1)
- third (1)
- thoracolumbar spine injury classification system (1)
- thoracolumbar trauma (1)
- three point bending test (1)
- three-dimensional analysis (1)
- three‐dimensional analysis (1)
- thrombocyte dysfunction (1)
- thrombocyte function (1)
- thrombocytopenia (1)
- thrombocytosis (1)
- thrombolysis (tPA) (1)
- thrombopenia (1)
- thrombopietin receptor agonist (1)
- thrombosis (1)
- thrombospondin-4 (1)
- thrombotic microangiopathy (1)
- thrombotic thrombocytopenic purpura (1)
- thyroglobulin mRNA (1)
- thyroid cancer (1)
- thyroid nodule (1)
- thyroid resection (1)
- thyroid surgery (1)
- tick (1)
- time-lapse imaging (1)
- tiotropium (1)
- tissue at risk (1)
- tissue engineering (1)
- tissue mechanics (1)
- tissue slice co-cultures (1)
- titanium (1)
- titanium particles (1)
- tobacco cessation (1)
- tobacco control (1)
- tobacco products (1)
- tobacco taxation (1)
- toc64 (1)
- tolerability (1)
- tolerance (1)
- toll-like receptors (1)
- tolvaptan (1)
- tomography (1)
- tongue edema (1)
- tooth (1)
- tooth autotransplantation (1)
- tooth transplantation (1)
- tooth wear (1)
- top-down (1)
- top-down processing (1)
- topical agent (1)
- topographic maps (1)
- top–down (1)
- total body score (1)
- total events (1)
- total flavonoids (1)
- total joint arthroplasty (TJA) (1)
- total phenols (1)
- toxic hemisphere syndrome (1)
- toxin B (1)
- tpileptogenesis (1)
- tracheobronchomalacia (1)
- tracking (1)
- tractography (1)
- traffic accident (1)
- traffic emissions (1)
- trafficking (1)
- training effects (1)
- training program (1)
- training transfer (1)
- trans-Golgi network (1)
- transapical aortic valve replacement (1)
- transarterial chemoembolization (TACE) (1)
- transbronchial biopsy (TBB) (1)
- transcatheter aortic valve replacement (1)
- transcatheter aortic valve replacement (TAVR) (1)
- transcatheter aortic valve replacement (TAVR), aortic valve stenosis (AS) (1)
- transcatheter closure (1)
- transcranial alternating current stimulation (tACS) (1)
- transcription factor (1)
- transcription factors (1)
- transcriptional profiling (1)
- transcriptional regulation of autophagy (1)
- transcriptome analysis (1)
- transcriptomics (1)
- transdifferentiation (1)
- transfemoral (1)
- transfer (1)
- transforming growth factor beta (1)
- transforming growth factor beta (TGF-β) (1)
- transforming growth factor-β (1)
- transgelin (1)
- transgenically augmented CAR NK cell (1)
- transient interactions (1)
- transient receptor potential channels (1)
- transient virtual lesion (1)
- transition (1)
- transjugular intrahepatic portosystemic shunt (TIPS) (1)
- transjugular portosystemic intrahepatic (1)
- transketolase-like protein 1 (1)
- translation (1)
- translational cancer research (1)
- translational medical research (1)
- translational medicine (1)
- translational reseach (1)
- translocation partner genes (1)
- translocon (1)
- transmission and vector control (1)
- transmission routes (1)
- transmitted founder virus (1)
- transportation (1)
- transposition (1)
- transrectal prostate biopsy (1)
- transsexualism (1)
- transurethral catheter (1)
- transverse axis (1)
- traumafocused cognitive behavioural therapy (1)
- traumatic brain injury (1)
- traumatic brain injury (TBI) (1)
- treatment choice (1)
- treatment preference (1)
- treatment-related changes (1)
- treatment-resistant (1)
- trehalose (1)
- triathlon (1)
- tricalcium phosphate (1)
- trichostatin A (1)
- trigeminal pain (1)
- triple therapy (1)
- trochee (1)
- trophiclevel (1)
- trophoblastic cell lines (1)
- trophoblasts (1)
- tropical marine sponges (1)
- troponin (1)
- trust (1)
- trustworthy AI (1)
- tryptophan (1)
- tuberculosis epidemiology (1)
- tuberous sclerosis complex (1)
- tubular regeneration (1)
- tuft cells (1)
- tumor (1)
- tumor adhesion (1)
- tumor cell proliferation (1)
- tumor dissemination (1)
- tumor growth in xenografts (1)
- tumor immune escape (1)
- tumor immune evasion (1)
- tumor invasion (1)
- tumor metabolism (1)
- tumor microenviroment (1)
- tumor microenvironment (TME) (1)
- tumor migration (1)
- tumor necrosis factor converting enzyme (1)
- tumor necrosis factor receptor superfamily member 9 (1)
- tumor pain (1)
- tumor proliferation (1)
- tumor response (1)
- tumor stroma (1)
- tumor weight (1)
- tumor xenograft (1)
- tumor-infiltrating-lymphocytes (1)
- tumor-specific antigen expressing dendritic cells (1)
- tumor‐associated macrophages (1)
- tumour (1)
- tumour growth (1)
- tumour immunology (1)
- tumour microenvironment (1)
- tumour-infiltrating lymphocytes (1)
- two-tissue compartment model (1)
- type 1 diabetes (1)
- type B (1)
- type I interferon (1)
- type I interferons (1)
- type I interferons (IFNs) (1)
- type-1-diabetes (1)
- tyrosinase inhibitor (1)
- tyrosine kinase inhibitors (1)
- tyrosine kinase inhibitors. (1)
- ubiquitin coat (1)
- ubiquitin receptor (1)
- ubiquitin-binding zinc finger (1)
- ulcerative colitis (1)
- ultra-high field MRI (1)
- unanticipated (1)
- uncertainty (1)
- understudied kinase (1)
- unfolded protein response (1)
- unguided (1)
- unilateral hip osteoarthritis (1)
- unique information (1)
- university hospitals (1)
- upper gastrointestinal cancer (1)
- urachal cancer (1)
- urethral stricture (1)
- urethroplasty (1)
- urinary diversion (1)
- urinary tract development (1)
- ursodeoxycholic acid (1)
- uterine cervical cancer (1)
- vaccination rates (1)
- vaccine acceptance (1)
- vaccine trial (1)
- vacuuming (1)
- vadimezan (1)
- validation studies (1)
- value frameworks (1)
- vancomycin (1)
- variability (1)
- vascular (1)
- vascular calcification (1)
- vascular complications (1)
- vascular disease (1)
- vascular disrupting agents (1)
- vascular dysfunction and inflammation (1)
- vascular endothelial growth factor (1)
- vascular endothelial growth factor receptor (1)
- vascular endothelial growth factor receptor 2 (1)
- vascular remodeling (1)
- vascular smooth muscle (1)
- vascular smooth muscle cells (1)
- vascular surgery (1)
- vasculogenic mimicry (1)
- vasoconstriction (1)
- vasodilation (1)
- vasopressin (1)
- vector-borne disease (1)
- velpatasvir (1)
- veneering porcelain (1)
- ventilation modes (1)
- ventral striatum (1)
- ventricular zone (VZ) (1)
- ventriculoperitoneal shunt (1)
- venturesomeness (1)
- versican (VCAN) (1)
- vertebrates (1)
- vertebroplasty (1)
- verzweigtkettige Aminosäuren (1)
- vesicovaginal septum (1)
- vesicular glutamate transporter 2 (1)
- vessel density (1)
- vessel-associated mural cells (1)
- vestibular schwannoma (1)
- viability (1)
- videos (1)
- vigilance (1)
- vincristine (1)
- violence (1)
- viral gene transfer (1)
- viral infection (1)
- viral tracing (1)
- viral vectors (1)
- virological failure (1)
- virulence (1)
- virus (1)
- virus-like particles (1)
- viscero-cutaneous (1)
- vision (1)
- vismodegib (1)
- vismodegib (GDC-0449) (1)
- visual cortex (1)
- visual illusion (1)
- visual priming (1)
- visual short-term memory (1)
- visual system (1)
- visuo-spatial attention (1)
- visuospatial attention (1)
- vitamin D deficiency (1)
- vitamin D metabolites (1)
- vitamin D receptor (1)
- vitamin D supplementation (1)
- vitamin D target genes (1)
- vitamin D3 (1)
- vitamin Dmetabolism (1)
- vitreomacular traction (1)
- vitreous samples (1)
- vocal cord dysfunction (1)
- vocal cord palsy (1)
- voice (1)
- volatile organic compounds (VOC) (1)
- volatile sedation (1)
- voltage sensitive dye imaging (1)
- voluntary training (1)
- von Willebrand disease (1)
- von Willebrand diseases (1)
- voxel-based morphometry (1)
- voxilaprevir (1)
- waking state (1)
- water parameter (1)
- wax layer (1)
- wear (1)
- western blotting (1)
- wheezing (1)
- white matter changes (1)
- white-matter (1)
- whole abdominal radiotherapy (1)
- whole genome sequencing (1)
- whole slide image (1)
- whole-brain modeling (1)
- wild animals (1)
- wild boar carcass (1)
- willingness to participate (1)
- winter survival (1)
- within-host viral modeling (1)
- women (1)
- words (1)
- work ability (1)
- work productivity (1)
- work-life balance (1)
- workplace health promotion (1)
- wound complications (1)
- xenobiotics (1)
- xenophagy (1)
- yeast-two-hybrid (Y2H) (1)
- yellow fever virus (1)
- yellow fever virus tropism (1)
- yield optimization (1)
- young people (1)
- youth football (1)
- zafirlukast (1)
- zebrafish development (1)
- zirconia (1)
- zymosan (1)
- Übernahme von Innovationen (1)
- Übertragungswege (1)
- Überwachung (1)
- ß-D-glucan (1)
- ß-tricalciumphosphate (1)
- α-amylase inhibitor (1)
- α-mannosidosis (1)
- α-particles (1)
- α-synuclein (1)
- αvβ3 integrin (1)
- β-catenin (1)
- β-lactamases (1)
- γH2AX (1)
- γδT cell (1)
- γ‐H2AX (1)
- μ-opioid receptor regulation (1)
- π-clamp (1)
- гепатит С (1)
- правила прекращения лечения (1)
- противовирусные препараты прямого действия (ПППД) (1)
- сокращение лечения (1)
- устойчивый вирусологический ответ (УВО) (1)
- “gatekeeper” mutation T315I (1)
- flow cytometry (1)
Institute
- Medizin (3562)
- Biowissenschaften (68)
- Georg-Speyer-Haus (59)
- Sonderforschungsbereiche / Forschungskollegs (56)
- Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit (ZAFES) (56)
- Biochemie und Chemie (46)
- Pharmazie (46)
- Exzellenzcluster Makromolekulare Komplexe (45)
- Frankfurt Institute for Advanced Studies (FIAS) (43)
- Präsidium (34)
Objective: We aimed to assess the correlation between serum prostate-specific antigen (PSA) and tumor burden in prostate cancer (PCa) patients undergoing radical prostatectomy (RP), because estimation of tumor burden is of high value, e.g., in men undergoing RP or with biochemical recurrence after RP. Patients and Methods: From January 2019 to June 2020, 179 consecutive PCa patients after RP with information on tumor and prostate weight were retrospectively identified from our prospective institutional RP database. Patients with preoperative systemic therapy (n=19), metastases (cM1, n=5), and locally progressed PCa (pT4 or pN1, n=50) were excluded from analyses. Histopathological features, including total weight of the prostate and specific tumor weight, were recorded by specialized uro-pathologists. Linear regression models were performed to evaluate the effect of PSA on tumor burden, measured by tumor weight after adjustment for patient and tumor characteristics. Results: Overall, median preoperative PSA was 7.0 ng/ml (interquartile range [IQR]: 5.41–10) and median age at surgery was 66 years (IQR: 61-71). Median prostate weight was 34 g (IQR: 26–46) and median tumor weight was 3.7 g (IQR: 1.8–7.1), respectively. In multivariable linear regression analysis after adjustment for patients and tumor characteristics, a significant, positive correlation could be detected between preoperative PSA and tumor weight (coefficient [coef.]: 0.37, CI: 0.15–0.6, p=0.001), indicating a robust increase in PSA of almost 0.4 ng/ml per 1g tumor weight. Conclusion: Preoperative PSA was significantly correlated with tumor weight in PCa patients undergoing RP, with an increase in PSA of almost 0.4 ng/ml per 1 g tumor weight. This might help to estimate both tumor burden before undergoing RP and in case of biochemical recurrence.
Artificial Intelligence (AI) has the potential to greatly improve the delivery of healthcare and other services that advance population health and wellbeing. However, the use of AI in healthcare also brings potential risks that may cause unintended harm. To guide future developments in AI, the High-Level Expert Group on AI set up by the European Commission (EC), recently published ethics guidelines for what it terms “trustworthy” AI. These guidelines are aimed at a variety of stakeholders, especially guiding practitioners toward more ethical and more robust applications of AI. In line with efforts of the EC, AI ethics scholarship focuses increasingly on converting abstract principles into actionable recommendations. However, the interpretation, relevance, and implementation of trustworthy AI depend on the domain and the context in which the AI system is used. The main contribution of this paper is to demonstrate how to use the general AI HLEG trustworthy AI guidelines in practice in the healthcare domain. To this end, we present a best practice of assessing the use of machine learning as a supportive tool to recognize cardiac arrest in emergency calls. The AI system under assessment is currently in use in the city of Copenhagen in Denmark. The assessment is accomplished by an independent team composed of philosophers, policy makers, social scientists, technical, legal, and medical experts. By leveraging an interdisciplinary team, we aim to expose the complex trade-offs and the necessity for such thorough human review when tackling socio-technical applications of AI in healthcare. For the assessment, we use a process to assess trustworthy AI, called 1Z-Inspection® to identify specific challenges and potential ethical trade-offs when we consider AI in practice.
Multinucleated giant cells (MNGCs) are frequently observed in the implantation areas of different biomaterials. The main aim of the present study was to analyze the long-term polarization pattern of the pro- and anti-inflammatory phenotypes of macrophages and MNGCs for 180 days to better understand their role in the success or failure of biomaterials. For this purpose, silk fibroin (SF) was implanted in a subcutaneous implantation model of Wistar rats as a model for biomaterial-induced MNGCs. A sham operation was used as a control for physiological wound healing. The expression of different inflammatory markers (proinflammatory M1: CCR-7, iNos; anti-inflammatory M2: CD-206, CD-163) and tartrate-resistant acid phosphatase (TRAP) and CD-68 were identified using immunohistochemical staining. The results showed significantly higher numbers of macrophages and MNGCs within the implantation bed of SF-expressed M1 markers, compared to M2 markers. Interestingly, the expression of proinflammatory markers was sustained over the long observation period of 180 days. By contrast, the control group showed a peak of M1 macrophages only on day 3. Thereafter, the inflammatory pattern shifted to M2 macrophages. No MNGCs were observed in the control group. To the best of our knowledge, this is study is the first to outline the persistence of pro-inflammatory MNGCs within the implantation bed of SF and to describe their long-term kinetics over 180 days. Clinically, these results are highly relevant to understand the role of biomaterial-induced MNGCs in the long term. These findings suggest that tailored physicochemical properties may be a key to avoiding extensive inflammatory reactions and achieving clinical success. Therefore, further research is needed to elucidate the correlation between proinflammatory MNGCs and the physicochemical characteristics of the implanted biomaterial.
The purpose of this narrative review is to discuss and highlight recently published studies regarding the surgical management of patients suffering from prostate cancer treatment complications. Focus will be put on the recalcitrant and more complex cases which might lead to urinary diversion as a definite, last resort treatment. It is in the nature of every treatment, that complications will occur and be bothersome for both patients and physicians. A small percentage of patients following prostate cancer treatment (radical prostatectomy, radiation therapy, or other focal therapies) will suffer side effects and thus, will experience a loss of quality of life. These side effects can persist for months and even years. Often, conservative management strategies fail resulting in recalcitrant recurrences. Prostate cancer patients with “end-stage bladder,” “devastated outlet,” or a history of multiple failed interventions, are fortunately rare, but can be highly challenging for both patients and Urologists. In a state of multiple previous surgical procedures and an immense psychological strain for the patient, urinary diversion can offer a definite, last resort surgical solution for this small group of patients. Ideally, they should be transferred to centers with experience in this field and a careful patient selection is needed. As these cases are highly complex, a multidisciplinary approach is often necessary in order to guarantee an improvement of quality of life.
Mitofusin 2 (MFN2) is a mitochondrial outer membrane GTPase, which modulates mitochondrial fusion and affects the interaction between endoplasmic reticulum and mitochondria. Here, we explored how MFN2 influences mitochondrial functions and inflammatory responses towards zymosan in primary human macrophages. A knockdown of MFN2 by small interfering RNA decreased mitochondrial respiration without attenuating mitochondrial membrane potential and reduced interactions between endoplasmic reticulum and mitochondria. A MFN2 deficiency potentiated zymosan-elicited inflammatory responses of human primary macrophages, such as expression and secretion of pro-inflammatory cytokines interleukin-1β, -6, -8 and tumor necrosis factor α, as well as induction of cyclooxygenase 2 and prostaglandin E2 synthesis. MFN2 silencing also increased zymosan-induced nuclear factor kappa-light-chain-enhancer of activated B cells and mitogen-activated protein kinases inflammatory signal transduction, without affecting mitochondrial reactive oxygen species production. Mechanistic studies revealed that MFN2 deficiency enhanced the toll-like receptor 2-dependent branch of zymosan-triggered responses upstream of inhibitor of κB kinase. This was associated with elevated, cytosolic expression of interleukin-1 receptor-associated kinase 4 in MFN2-deficient cells. Our data suggest pro-inflammatory effects of MFN2 deficiency in human macrophages.
Background and Aims: Activation of the inflammasome NLRP3 (NOD-, LRR- and pyrin domain containing 3) contributes to the development of non-alcoholic fatty liver disease (NAFLD) and progression to non-alcoholic steatohepatitis (NASH). Therefore, this study explored the therapeutic effects of a novel and selective NLRP3 antagonist in a murine dietary model of NASH. Methods: Groups of 12-week-old ApoE-/- mice were fed ad lib for 7 weeks with a methionine/choline deficient (MCD) and western diet (WD). After 3 weeks of diet-induced injury, mice were injected i. p. with the NLRP3 antagonist IFM-514 (100 mg/kg body weight) or vehicle (0.5% carmellose) every day, 5 days/week for a further 4 weeks. Several markers of inflammation, fibrosis and steatosis were evaluated. Whole transcriptome sequencing and panel RNA expression analysis (NanoString) were performed. Results: IFM-514 inhibited IL-1β production in mice challenged with 20 mg/kg lipopolysaccharide, and in mouse and human inflammatory cells in vitro. IFM-514 inhibited hepatic inflammation in the in vivo non-alcoholic steatohepatitis model assessed by H&E staining and in the hepatic gene expression of inflammasome-related proinflammatory cytokines. This effect was associated with significant reduction in caspase-1 activation. Similarly, IFM-514 was efficacious in vivo in MDC-fed ApoE-/- mice, markedly reducing portal pressure, Sirius red staining and 4-hydroxyproline content compared to vehicle-treated mice. Moreover, IFM-514 significantly reduced hepatic steatosis in MCD-fed ApoE-/- mice, as evidenced by NAFLD scores, oil red O staining, hepatic triglycerides and gene expression. In WD treated animals, similar trends in inflammation and fibrosis were observed, although not sufficient IFM-514 levels were reached. Conclusion: Overall, IFM-514 reduced liver inflammation and fibrosis, with mild effects on liver steatosis in experimental murine NASH. Blocking of NLRP3 may be an attractive therapeutic approach for NASH patients.
Introduction: Gastroesophageal reflux disease (GERD) is associated with accelerated decline in lung health in children with cystic fibrosis (CF). Thus, antireflux surgery (ARS) is offered to a selected CF cohort with refractory GERD, but outcomes remain poorly investigated. This study aimed to determine the incidence of GERD in children with CF and to evaluate complications and outcomes of ARS. Materials and Methods: A systematic literature-based search was conducted using various online databases according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The number of GERD cases in pediatric CF cohorts who underwent diagnostic investigation(s) was recorded. Data on postoperative complications and outcomes (including symptoms, lung function, and nutritional status) following ARS were analyzed. Results: Ten articles (n = 289 patients) met the defined inclusion criteria (51% male; age range, 0.5 month–36 years). The overall incidence of GERD was 46% (range, 19–81%), derived from seven studies (n = 212 patients). Four publications (n = 82 patients) reported on ARS due to uncontrolled GERD. All ARSs were Nissen fundoplication (majority with gastrostomy placement). Major postoperative complications occurred in 15 (18%) patients, two required redo-ARS. Median follow-up time was 2 years (range, 3 months–6 years); 59% showed symptom improvement, and pulmonary exacerbations and decline in lung function were reduced. Nutritional status mainly improved in milder CF cases. There were no deaths related to ARS. Conclusion: Approximately half of pediatric CF patients have GERD. Published data for children with CF are limited and heterogeneous in terms of GERD diagnosis and outcomes following ARS. However, ARS has shown to slow the deterioration of lung function in CF.
Biomedinformatics: A New Journal for the New Decade to Publish Biomedical Informatics Research
(2021)
With this volume, the peer-reviewed open access journal Biomedinformatics published online on the website https://www.mdpi.com/journal/biomedinformatics, and bearing the current International Standard Serial Number ISSN 2673-7426 enters the scientific community. At the beginning of the 3rd decade of the 21st century, this new journal is dedicated to research reports in the field of biomedical informatics. Biomedinformatics appears at a time when computational methods have reached clinical practice and the transformation to digital medicine is accelerating. Both digitized healthcare and bioinformatics-based research is producing and benefiting from increasingly complex data. This requires the development of tools and methods to extract information from these data and translate it into new knowledge. While biomedical research continues to require clinical and experi- mental data collection, digital healthcare research has clearly evolved from a collection of supporting methods to an equivalent scientific approach, enabling a paradigm shift from almost exclusively hypothesis-driven approaches to increasingly data-driven biomedical research. Indeed, computational science is a rapidly growing multidisciplinary field that uses advanced computational capabilities to understand and solve complex problems by applying new methods of computational intelligence, machine learning, and advanced statistics [1].
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the acute respiratory disease COVID-19, which has become a global concern due to its rapid spread. The common methods to monitor and quantitate SARS-CoV-2 infectivity in cell culture are so far time-consuming and labor-intensive. Using the Sleeping Beauty transposase system, we generated a robust and versatile cellular infection model that allows SARS-CoV-2 infection experiments compatible for high-throughput and live cell imaging. The model is based on lung derived A549 cells, which show a profound interferon response and convenient cell culture characteristics. ACE2 and TMPRSS2 were introduced for constitutive expression (A549-AT). Subclones with varying levels of ACE2/TMPRSS2 were screened for optimal SARS-CoV-2 susceptibility. Furthermore, extensive evaluation demonstrated that SARS-CoV-2 infected A549-AT cells were distinguishable from mock-infected cells and already showed approximately 12 h post infection a clear signal to noise ratio in terms of cell roughness, fluorescence and a profound visible cytopathic effect. Moreover, due to the high transfection efficiency and proliferation capacity, Sleeping Beauty transposase-based overexpression cell lines with a second inducible fluorescence reporter cassette (eGFP) can be generated in a very short time, enabling the investigation of host and restriction factors in a doxycycline-inducible manner. Thus, the novel model cell line allows rapid and sensitive monitoring of SARS-CoV-2 infection and the screening for host factors essential for viral replication. HIGHLIGHTS: Sleeping Beauty transposon-based cellular system was used to generate a highly susceptible cell line for monitoring SARS-CoV-2 infection; The versatile model cell line A549-AT is suitable for rapid and sensitive high-throughput assays; Additional gene specific expression cassettes allow the screening for compounds and cellular factors limiting SARS-CoV-2 replication.
Background: dental professionals suffer frequently from musculoskeletal disorders (MSD). Dentists and dental assistants work closely with each other in a mutually dependent relationship. To date, MSD in dental assistants have only been marginally investigated and compared to their occurrence in dentists. Therefore, the aim of this study was to compare the prevalence of MSD between dentists and dental assistants by considering occupational factors, physical activity and gender. Methods: This was a cross-sectional observational study. A Germany-wide survey, using a modified version of the Nordic Questionnaire and work-related questions, was applied. In total, 2548 participants took part, of which 389 dentists (240 females and 149 males) and 322 dental assistants (320 females and 2 males) were included in the analysis. Data were collected between May 2018 and May 2019. Differences between the dentists and dental assistants were determined by using the Chi2 test for nominal and the Wilcoxon–Mann–Whitney U test for both ordinal and non-normally distributed metric data. Results: A greater number of dental assistants reported complaints than dentists in all queried body regions. Significant differences in the most affected body regions (neck, shoulders, wrist/hands, upper back, lower back and feet/ankles) were found for the lifetime prevalence, annual prevalence and weekly prevalence. Data from the occupational factors, physical activity and gender analyses revealed significant differences between dentists and dental assistants. Conclusions: Dental assistants appear to be particularly affected by MSD when compared to dentists. This circumstance can be explained only to a limited extent by differences in gender distribution and occupational habits between the occupations.
Clinical data on antifungal combination therapy are limited, in particular in the pediatric setting. We analyzed real-life data collected in two major pediatric cancer centers over a period of 4 years. Patients were identified in an observational study on children with acute leukemia and lymphoma or undergoing hematopoietic cell transplantation. Out of 438 patients, 19 patients received 21 episodes of antifungal combination therapy. Therapy was mostly started for sepsis (n = 5) or clinical deterioration with pulmonary infiltrates (n = 10), and less often for periorbital swelling with suspected mold infection (n = 2), clinical deterioration and new skin lesions, secondary antifungal prophylaxis, a persistently elevated galactomannan index, or as pre-emptive treatment (n = 1 each). Diagnostics revealed proven, probable, and possible invasive fungal disease in two, seven and four episodes, respectively. Most regimens included caspofungin (n = 19), and treatment was initiated as first line therapy in 10 episodes. The median duration was 13 days (4–46 days). Nine of the 13 patients with proven, probable, or possible invasive fungal disease survived, which was comparable to patients receiving antifungal monotherapy. Our analysis demonstrates that combination therapy has mainly been prescribed in selected immunocompromised patients with clinical deterioration due to suspected invasive fungal disease or those with sepsis, and is well tolerated. Future studies need to better characterize clinical settings in which patients may benefit from antifungal combination therapy.
Endothelial cells can acquire a mesenchymal phenotype through a process called Endothelial-to-Mesenchymal transition (EndMT). This event is found in embryonic development, but also in pathological conditions. Blood vessels lose their ability to maintain vascular homeostasis and ultimately develop atherosclerosis, pulmonary hypertension, or fibrosis. An increase in inflammatory signals causes an upregulation of EndMT transcription factors, mesenchymal markers, and a decrease in endothelial markers. In our study, we show that the induction of EndMT results in an increase in long non-coding RNA AERRIE expression. JMJD2B, a known EndMT regulator, induces AERRIE and subsequently SULF1. Silencing of AERRIE shows a partial regulation of SULF1 but showed no effect on the endothelial and mesenchymal markers. Additionally, the overexpression of AERRIE results in no significant changes in EndMT markers, suggesting that AERRIE is marginally regulating mesenchymal markers and transcription factors. This study identifies AERRIE as a novel factor in EndMT, but its mechanism of action still needs to be elucidated.
Background: Current literature is inconsistent regarding the risk of severe side effects using accelerated induction protocols in Hymenoptera venom immunotherapy (VIT). In addition, several data indicate the influence of purity grade of venom preparation on tolerability. We evaluated the safety and tolerability of ultra-rush and rush build-up protocols using purified and non-purified venom preparations. Methods: Retrospective single-center study of 581 VIT inductions (325 ultra-rush and 256 rush protocols) from 2005 to 2018 in 559 patients with bee and vespid venom allergy using aqueous purified (ALK SQ®) for ultra-rush protocol and aqueous non-purified (ALK Reless®) venom preparations for rush protocol. Results: Urticaria (8% vs. 3.1%, p = 0,013) and dose reductions (4.3% vs. 1.2%, p = 0,026) were significantly more frequent in the ultra-rush group. Overall rate of moderate-to-severe side effects (anaphylaxis ≥grade 2 according to Ring and Meβmer) was low and did not differ significantly between protocols (p = 0.105). Severe events (grade 4 anaphylaxis) were not reported. Discontinuation rate was very low in both cohorts (0.6% vs 1.2%). The higher purity grade of venom preparations in the ultra-rush cohort did not improve tolerability. The bee venom group showed a non-significant trend towards higher incidence of mild reactions (urticaria), resulting in more frequent dose reductions and antiallergic therapy. Conclusion: Rush and ultra-rush protocols show an excellent safety profile with only infrequent and mild anaphylactic reactions in bee and vespid venom allergy. Ultra-rush immunotherapy reduces the duration of the inpatient build-up phase setting and thus is viewed by the authors as preferred treatment in Hymenoptera venom allergic patients.
Background: Dental professionals are subjected to higher risks for musculoskeletal disorders (MSDs) than other professional groups, especially the hand region. This study aims to investigate the prevalence of hand complaints among dentists (Ds) and dental assistants (DAs) and examines applied therapies. Methods: For this purpose, an online questionnaire analysed 389 Ds (240female/149male) and 406 DAs (401female/5male) working in Germany. The self-reported data of the two occupational groups were compared with regard to the topics examined. The questionnaire was based on the Nordic Questionnaire (self-reported lifetime, 12-month and 7-day MSDs prevalence of the hand, the conducted therapy and its success), additional occupational and sociodemographic questions as well as questions about specific medical conditions. Results: 30.8% of Ds affirmed MSDs in the hand at any time in their lives, 20.3% in the last twelve months and 9.5% in the last seven days. Among DAs, 42.6% reported a prevalence of MSDs in the hand at any time in their lives, 31.8% in the last 12 months and 15.3% in the last seven days. 37.5% of the Ds and 28.3% of the DAs stated that they had certain treatments. For both, Ds and DAs, physiotherapy was the most frequently chosen form of therapy. 89.7% of Ds and 63.3% of DAs who received therapy reported an improvement of MSDs. Conclusion: Although the prevalence of MSDs on the hand is higher among DAs than among Ds, the use of therapeutic options and the success of therapy is lower for DAs compared to Ds.
This study deals with 3D laser investigation on the border between the human lymph node T-zone and germinal centre. Only a few T-cells specific for antigen selected B-cells are allowed to enter germinal centres. This selection process is guided by sinus structures, chemokine gradients and inherent motility of the lymphoid cells. We measured gaps and wall-like structures manually, using IMARIS, a 3D image software for analysis and interpretation of microscopy datasets. In this paper, we describe alpha-actin positive and semipermeable walls and wall-like structures that may hinder T-cells and other cell types from entering germinal centres. Some clearly defined holes or gaps probably regulate lymphoid traffic between T- and B-cell areas. In lymphadenitis, the morphology of this border structure is clearly defined. However, in case of malignant lymphoma, the wall-like structure is disrupted. This has been demonstrated exemplarily in case of angioimmunoblastic T-cell lymphoma. We revealed significant differences of lengths of the wall-like structures in angioimmunoblastic T-cell lymphoma in comparison with wall-like structures in reactive tissue slices. The alterations of morphological structures lead to abnormal and less controlled T- and B-cell distributions probably preventing the immune defence against tumour cells and infectious agents by dysregulating immune homeostasis.
Background: The intraoperative blood loss is estimated daily in the operating room and is mainly done by visual techniques. Due to local standards, the surgical sponge colours can vary (e.g. white in US, green in Germany). The influence of sponge colour on accuracy of estimation has not been in the focus of research yet. Material and methods: A blood loss simulation study containing four “bleeding” scenarios each per sponge colour were created by using expired whole blood donation samples. The blood donations were applied to white and green surgical sponges after dilution with full electrolyte solution. Study participants had to estimate the absorbed blood loss in sponges in all scenarios. The difference to the reference blood loss was analysed. Multivariate linear regression analysis was performed to investigate other influence factors such as staff experience and sponge colour. Results: A total of 53 anaesthesists participated in the study. Visual estimation correlated moderately with reference blood loss in white (Spearman's rho: 0.521; p = 3.748*10−16) and green sponges (Spearman's rho: 0.452; p = 4.683*10−12). The median visually estimated blood loss was higher in white sponges (250ml IRQ 150–412.5ml) than in green sponges (150ml IQR 100-300ml), compared to reference blood loss (103ml IQR 86–162.8). For both colour types of sponges, major under- and overestimation was observed. The multivariate statistics demonstrates that fabric colours have a significant influence on estimation (p = 3.04*10−10), as well as clinician’s qualification level (p = 2.20*10−10, p = 1.54*10−08) and amount of RBL to be estimated (p < 2*10−16). Conclusion: The deviation of correct blood loss estimation was smaller with white surgical sponges compared to green sponges. In general, deviations were so severe for both types of sponges, that it appears to be advisable to refrain from visually estimating blood loss whenever possible and instead to use other techniques such as e.g. colorimetric estimation.
Objectives: In this study, localization accuracy and sensitivity to acoustic interaural time differences (ITDs) in subjects using cochlear implants with combined electric-acoustic stimulation (EAS) were assessed and compared with the results of a normal hearing control group. Methods: Eight CI users with EAS (2 bilaterally implanted, 6 unilaterally implanted) and symmetric binaural acoustic hearing and 24 normal hearing subjects participated in the study. The first experiment determined mean localization error (MLE) for different angles of sound incidence between ± 60° (frontal and dorsal presentation). The stimuli were either low-pass, high-pass or broadband noise bursts. In a second experiment, just noticeable differences (JND) of ITDs were measured for pure tones of 125 Hz, 250 Hz and 500 Hz (headphone presentation). Results: Experiment 1: MLE of EAS subjects was 8.5°, 14.3° and 14.7°, (low-, high-pass and broadband stimuli respectively). In the control group, MLE was 1.8° (broadband stimuli). In the differentiation between sound incidence from front and back, EAS subjects performed on chance level. Experiment 2: The JND-ITDs were 88.7 μs for 125 Hz, 48.8 μs for 250 Hz and 52.9 μs for 500 Hz (EAS subjects). Compared to the control group, JND-ITD for 125 Hz was on the same level of performance. No statistically significant correlation was found between MLE and JND-ITD in the EAS cohort. Conclusions: Near to normal ITD sensitivity in the lower frequency acoustic hearing was demonstrated in a cohort of EAS users. However, in an acoustic localization task, the majority of the subjects did not reached the level of accuracy of normal hearing. Presumably, signal processing time delay differences between devices used on both sides are deteriorating the transfer of precise binaural timing cues.
Background: Anemia is the most important complication during major surgery and transfusion of red blood cells is the mainstay to compensate for life threating blood loss. Therefore, accurate measurement of hemoglobin (Hb) concentration should be provided in real-time. Blood Gas Analysis (BGA) provides rapid point-of-care assessment using smaller sampling tubes compared to central laboratory (CL) services. Objective: This study aimed to investigate the accuracy of BGA hemoglobin testing as compared to CL services. Methods: Data of the ongoing LIBERAL-Trial (Liberal transfusion strategy to prevent mortality and anemia-associated ischemic events in elderly non-cardiac surgical patients, LIBERAL) was used to assess the bias for Hb level measured by BGA devices (ABL800 Flex analyzer®, GEM series® and RapidPoint 500®) and CL as the reference method. For that, we analyzed pairs of Hb level measured by CL and BGA within two hours. Furthermore, the impact of various confounding factors including age, gender, BMI, smoker status, transfusion of RBC, intraoperative hemodilution, and co-medication was elucidated. In order to ensure adequate statistical analysis, only data of participating centers providing more than 200 Hb pairs were used. Results: In total, three centers including 963 patients with 1,814 pairs of Hb measurements were analyzed. Mean bias was comparable between ABL800 Flex analyzer® and GEM series®: - 0.38 ± 0.15 g/dl whereas RapidPoint 500® showed a smaller bias (-0.09 g/dl) but greater median absolute deviation (± 0.45 g/dl). In order to avoid interference with different standard deviations caused by the different analytic devices, we focused on two centers using the same BGA technique (309 patients and 1,570 Hb pairs). A Bland-Altman analysis and LOWESS curve showed that bias decreased with smaller Hb values in absolute numbers but increased relatively. The smoker status showed the greatest reduction in bias (0.1 g/dl, p<0.001) whereas BMI (0.07 g/dl, p = 0.0178), RBC transfusion (0.06 g/dl, p<0.001), statins (0.04 g/dl, p<0.05) and beta blocker (0.03 g/dl, p = 0.02) showed a slight effect on bias. Intraoperative substitution of volume and other co-medications did not influence the bias significantly. Conclusion: Many interventions like substitution of fluids, coagulating factors or RBC units rely on the accuracy of laboratory measurement devices. Although BGA Hb testing showed a consistently stable difference to CL, our data confirm that BGA devices are associated with different bias. Therefore, we suggest that hospitals assess their individual bias before implementing BGA as valid and stable supplement to CL. However, based on the finding that bias decreased with smaller Hb values, which in turn are used for transfusion decision, we expect no unnecessary or delayed RBC transfusion, and no major impact on the LIBERAL trial performance.
Objectives: To review systematically the past 10 years of research activity into the healthcare experiences (HCX) of patients with chronic heart failure (CHF) in Germany, in order to identify research foci and gaps and make recommendations for future research. Design: In this scoping review, six databases and grey literature sources were systematically searched for articles reporting HCX of patients with CHF in Germany that were published between 2008 and 2018. Extracted results were summarised using quantitative and qualitative descriptive analysis. Results: Of the 18 studies (100%) that met the inclusion criteria, most were observational studies (60%) that evaluated findings quantitatively (60%). HCX were often concerned with patient information, global satisfaction as well as relationships and communication between patients and providers and generally covered ambulatory care, hospital care and rehabilitation services. Overall, the considerable heterogeneity of the included studies’ outcomes only permitted relatively trivial levels of synthesis. Conclusion: In Germany, research on HCX of patients with CHF is characterised by missing, inadequate and insufficient information. Future research would benefit from qualitative analyses, evidence syntheses, longitudinal analyses that investigate HCX throughout the disease trajectory, and better reporting of sociodemographic data. Furthermore, research should include studies that are based on digital data, reports of experiences gained in under-investigated yet patient-relevant healthcare settings and include more female subjects.
The intestinal epithelium acts as a selective barrier for the absorption of water, nutrients and orally administered drugs. To evaluate the gastrointestinal permeability of a candidate molecule, scientists and drug developers have a multitude of cell culture models at their disposal. Static transwell cultures constitute the most extensively characterized intestinal in vitro system and can accurately categorize molecules into low, intermediate and high permeability compounds. However, they lack key aspects of intestinal physiology, including the cellular complexity of the intestinal epithelium, flow, mechanical strain, or interactions with intestinal mucus and microbes. To emulate these features, a variety of different culture paradigms, including microfluidic chips, organoids and intestinal slice cultures have been developed. Here, we provide an updated overview of intestinal in vitro cell culture systems and critically review their suitability for drug absorption studies. The available data show that these advanced culture models offer impressive possibilities for emulating intestinal complexity. However, there is a paucity of systematic absorption studies and benchmarking data and it remains unclear whether the increase in model complexity and costs translates into improved drug permeability predictions. In the absence of such data, conventional static transwell cultures remain the current gold-standard paradigm for drug absorption studies.
Background: Dentists are at a higher risk of suffering from musculoskeletal disorders (MSD) than the general population. However, the latest study investigating MSD in the dental profession in Germany was published about 20 years ago. Therefore, the aim of this study was to reveal the current prevalence of MSD in dentists and dental students in Germany. Methods: The final study size contained 450 (287 f/163 m) subjects of different areas of specialization. The age of the participants ranged from 23 to 75 years. The questionnaire consisted of a modified version of the Nordic Questionnaire, work-related questions from the latest questionnaire of German dentists, typical medical conditions and self-developed questions. Results: The overall prevalence showed that dentists suffered frequently from MSD (seven days: 65.6%, twelve months: 92%, lifetime: 95.8%). The most affected body regions included the neck (42.7%–70.9%–78.4%), shoulders (29.8%–55.6%–66.2%) and lower back (22.9%–45.8%–58.7%). Overall, female participants stated that they suffered from pain significantly more frequently, especially in the neck, shoulders and upper back. Conclusion: The prevalence of MSD among dentists, especially in the neck, shoulder and back area, was significantly higher than in the general population. In addition, women suffered more frequently from MSD than men in almost all body regions.
Large spines are stable and important for memory trace formation. The majority of large spines also contains synaptopodin (SP), an actin-modulating and plasticity-related protein. Since SP stabilizes F-actin, we speculated that the presence of SP within large spines could explain their long lifetime. Indeed, using 2-photon time-lapse imaging of SP-transgenic granule cells in mouse organotypic tissue cultures we found that spines containing SP survived considerably longer than spines of equal size without SP. Of note, SP-positive (SP+) spines that underwent pruning first lost SP before disappearing. Whereas the survival time courses of SP+ spines followed conditional two-stage decay functions, SP-negative (SP-) spines and all spines of SP-deficient animals showed single-phase exponential decays. This was also the case following afferent denervation. These results implicate SP as a major regulator of long-term spine stability: SP clusters stabilize spines, and the presence of SP indicates spines of high stability.
Prostate cancer patients whose tumors develop resistance to conventional treatment often turn to natural, plant-derived products, one of which is sulforaphane (SFN). This study was designed to determine whether anti-tumor properties of SFN, identified in other tumor entities, are also evident in cultivated DU145 and PC3 prostate cancer cells. The cells were incubated with SFN (1–20 µM) and tumor cell growth and proliferative activity were evaluated. Having found a considerable anti-growth, anti-proliferative, and anti-clonogenic influence of SFN on both prostate cancer cell lines, further investigation into possible mechanisms of action were performed by evaluating the cell cycle phases and cell-cycle-regulating proteins. SFN induced a cell cycle arrest at the S- and G2/M-phase in both DU145 and PC3 cells. Elevation of histone H3 and H4 acetylation was also evident in both cell lines following SFN exposure. However, alterations occurring in the Cdk-cyclin axis, modification of the p19 and p27 proteins and changes in CD44v4, v5, and v7 expression because of SFN exposure differed in the two cell lines. SFN, therefore, does exert anti-tumor properties on these two prostate cancer cell lines by histone acetylation and altering the intracellular signaling cascade, but not through the same molecular mechanisms.
Human placentation is a highly invasive process. Deficiency in the invasiveness of trophoblasts is associated with a spectrum of gestational diseases, such as preeclampsia (PE). The oncogene B-cell lymphoma 6 (BCL6) is involved in the migration and invasion of various malignant cells. Intriguingly, its expression is deregulated in preeclamptic placentas. We have reported that BCL6 is required for the proliferation, survival, fusion, and syncytialization of trophoblasts. In the present work, we show that the inhibition of BCL6, either by its gene silencing or by using specific small molecule inhibitors, impairs the migration and invasion of trophoblastic cells, by reducing cell adhesion and compromising the dynamics of the actin cytoskeleton. Moreover, the suppression of BCL6 weakens the signals of the phosphorylated focal adhesion kinase, Akt/protein kinase B, and extracellular regulated kinase 1/2, accompanied by more stationary, but less migratory, cells. Interestingly, transcriptomic analyses reveal that a small interfering RNA-induced reduction of BCL6 decreases the levels of numerous genes, such as p21 activated kinase 1, myosin light chain kinase, and gamma actin related to cell adhesion, actin dynamics, and cell migration. These data suggest BCL6 as a crucial player in the migration and invasion of trophoblasts in the early stages of placental development through the regulation of various genes associated with the migratory machinery.
Background: paediatric patients are vulnerable to blood loss and even a small loss of blood can be associated with severe shock. In emergency situations, a red blood cell (RBC) transfusion may become unavoidable, although it is associated with various risks. The aim of this trial was to identify independent risk factors for perioperative RBC transfusion in children undergoing surgery. Methods: to identify independent risk factors for perioperative RBC transfusion in children undergoing surgery and to access RBC transfusion rates and in-hospital outcomes (e.g., length of stay, mortality, and typical postoperative complication rates), a monocentric, retrospective, and observational study was conducted. Descriptive, univariate, and multivariate analyses were performed. Results: between 1 January 2010 and 31 December 2019, data from n = 14,248 cases were identified at the centre. Analysis revealed an RBC transfusion rate of 10.1% (n = 1439) in the entire cohort. The independent predictors of RBC transfusion were the presence of preoperative anaemia (p < 0.001; OR = 15.10 with preoperative anaemia and OR = 2.40 without preoperative anaemia), younger age (p < 0.001; ORs between 0.14 and 0.28 for children older than 0 years), female gender (p = 0.036; OR = 1.19 compared to male gender), certain types of surgery (e.g., neuro surgery (p < 0.001; OR = 10.14), vascular surgery (p < 0.001; OR = 9.93), cardiac surgery (p < 0.001; OR = 4.79), gynaecology (p = 0.014; OR = 3.64), visceral surgery (p < 0.001; OR = 2.48), and the presence of postoperative complications (e.g., sepsis (p < 0.001; OR = 10.16), respiratory dysfunction (p < 0.001; OR = 7.56), cardiovascular dysfunction (p < 0.001; OR = 4.68), neurological dysfunction (p = 0.029; OR = 1.77), and renal dysfunction (p < 0.001; OR = 16.17)). Conclusion: preoperative anaemia, younger age, female gender, certain types of surgery, and postoperative complications are independent predictors for RBC transfusion in children undergoing surgery. Future prospective studies are urgently required to identify, in detail, the potential risk factors and impact of RBC transfusion in children.
Background: Abnormalities of heart rate (HR) and its variability are characteristic of major depressive disorder (MDD). However, circadian rhythm is rarely taken into account when statistically exploring state or trait markers for depression. Methods: A 4-day electrocardiogram was recorded for 16 treatment-resistant patients with MDD and 16 age- and sex-matched controls before, and for the patient group only, after a single treatment with the rapid-acting antidepressant ketamine or placebo (clinical trial registration available on https://www.clinicaltrialsregister.eu/ with EUDRACT number 2016-001715-21). Circadian rhythm differences of HR and the root mean square of successive differences (RMSSD) were compared between groups and were explored for classification purposes. Baseline HR/RMSSD were tested as predictors for treatment response, and physiological measures were assessed as state markers. Results: Patients showed higher HR and lower RMSSD alongside marked reductions in HR amplitude and RMSSD variation throughout the day. Excellent classification accuracy was achieved using HR during the night, particularly between 2 and 3 a.m. (90.6%). A positive association between baseline HR and treatment response (r = 0.55, p = 0.046) pointed toward better treatment outcome in patients with higher HR. Heart rate also decreased significantly following treatment but was not associated with improved mood after a single infusion of ketamine. Limitations: Our study had a limited sample size, and patients were treated with concomitant antidepressant medication. Conclusion: Patients with depression show a markedly reduced amplitude for HR and dysregulated RMSSD fluctuation. Higher HR and lower RMSSD in depression remain intact throughout a 24-h day, with the highest classification accuracy during the night. Baseline HR levels show potential for treatment response prediction but did not show potential as state markers in this study.
Transfusion of red blood cells (RBC) in patients undergoing major elective cranial surgery is associated with increased morbidity, mortality and prolonged hospital length of stay (LOS). This retrospective single center study aims to identify the clinical outcome of RBC transfusions on skull base and non-skull base meningioma patients including the identification of risk factors for RBC transfusion. Between October 2009 and October 2016, 423 patients underwent primary meningioma resection. Of these, 68 (16.1%) received RBC transfusion and 355 (83.9%) did not receive RBC units. Preoperative anaemia rate was significantly higher in transfused patients (17.7%) compared to patients without RBC transfusion (6.2%; p = 0.0015). In transfused patients, postoperative complications as well as hospital LOS was significantly higher (p < 0.0001) compared to non-transfused patients. After multivariate analyses, risk factors for RBC transfusion were preoperative American Society of Anaesthesiologists (ASA) physical status score (p = 0.0247), tumor size (p = 0.0006), surgical time (p = 0.0018) and intraoperative blood loss (p < 0.0001). Kaplan-Meier curves revealed significant influence on overall survival by preoperative anaemia, RBC transfusion, smoking, cardiovascular disease, preoperative KPS ≤ 60% and age (elderly ≥ 75 years). We concluded that blood loss due to large tumors or localization near large vessels are the main triggers for RBC transfusion in meningioma patients paired with a potential preselection that masks the effect of preoperative anaemia in multivariate analysis. Further studies evaluating the impact of preoperative anaemia management for reduction of RBC transfusion are needed to improve the clinical outcome of meningioma patients.
Background: MitraClip ® (MC) is an established procedure for severe mitral regurgitation (MR) in patients deemed unsuitable for surgery. Right ventricular dysfunction (RVD) is associated with a higher mortality risk. The prognostic accuracy of heart failure risk scores like the Seattle heart failure model (SHFM) and Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) score in pts undergoing MC with or without RVD has not been investigated so far. Methods: SHFM and MAGGIC score were calculated retrospectively. RVD was determined as tricuspid annular plane systolic excursion (TAPSE) ≤15 mm. Area under receiver operating curves (AUROC) of SHFM and MAGGIC were performed for one-year all-cause mortality after MC. Results: N = 103 pts with MR III° (73 ± 11 years, LVEF 37 ± 17%) underwent MC with a reduction of at least I° MR. One-year mortality was 28.2%. In Kaplan-Meier analysis, one- year mortality was significantly higher in RVD-pts (34.8% vs 2.8%, p = 0.009). Area under the Receiver Operating Characteristic (AUROC) for SHFM and MAGGIC were comparable for both scores (SHFM: 0.704, MAGGIC: 0.692). In pts without RVD, SHFM displayed a higher AUROC and therefore better diagnostic accuracy (SHFM: 0.776; MAGGIC: 0.551, p < 0.05). In pts with RVD, MAGGIC and SHFM displayed comparable AUROCs. Conclusion: RVD is an important prognostic marker in pts undergoing MC. SHFM and MAGGIC displayed adequate over-all prognostic power in these pts. Accuracy differed in pts with and without RVD, indicating higher predictive power of the SHFM score in pts without RVD.
The NADPH oxidase Nox4 is a hydrogen peroxide (H2O2)-producing enzyme, with the highest expression in the kidney. As the kidney is involved in volume and blood pressure control through sodium handling, we set out to determine the impact of a low sodium diet on these parameters in WT and Nox4-/- mice. Nox4 expression in the murine kidney was restricted to the proximal tubule. Nevertheless, low-sodium-induced weight loss and sodium sparing function was similar in WT and Nox4-/- mice, disputing an important function of renal Nox4 in sodium handling. In contrast, a low sodium diet resulted in a reduction in systolic blood pressure in Nox4-/- as compared to WT mice. This was associated with a selectively lower pressure to heart-rate ratio, as well as heart to body weight ratio. In general, a low sodium diet leads to activation of sympathetic tone and the renin angiotensin system, which subsequently increases peripheral resistance. Our observations suggest that the control by this system is attenuated in Nox4-/- mice, resulting in lower blood pressure in response to low sodium.
Triathletes often experience incoordination at the start of a transition run (TR); this is possibly reflected by altered joint kinematics. In this study, the first 20 steps of a run after a warm-up run (WR) and TR (following a 90 min cycling session) of 16 elite, male, long-distance triathletes (31.3 ± 5.4 years old) were compared. Measurements were executed on the competition course of the Ironman Frankfurt in Germany. Pacing and slipstream were provided by a cyclist in front of the runner. Kinematic data of the trunk and leg joints, step length, and step rate were obtained using the MVN Link inertial motion capture system by Xsens. Statistical parametric mapping was used to compare the active leg (AL) and passive leg (PL) phases of the WR and TR. In the TR, more spinal extension (~0.5–1°; p = 0.001) and rotation (~0.2–0.5°; p = 0.001–0.004), increases in hip flexion (~3°; ~65% AL−~55% PL; p = 0.001–0.004), internal hip rotation (~2.5°; AL + ~0–30% PL; p = 0.001–0.024), more knee adduction (~1°; ~80–95% AL; p = 0.001), and complex altered knee flexion patterns (~2–4°; AL + PL; p = 0.001–0.01) occurred. Complex kinematic differences between a WR and a TR were detected. This contributes to a better understanding of the incoordination in transition running.
During the course of sepsis in critically ill patients, kidney dysfunction and damage are among the first events of a complex scenario toward multi-organ failure and patient death. Acute kidney injury triggers the release of lipocalin-2 (Lcn-2), which is involved in both renal injury and recovery. Taking into account that Lcn-2 binds and transports iron with high affinity, we aimed at clarifying if Lcn-2 fulfills different biological functions according to its iron-loading status and its cellular source during sepsis-induced kidney failure. We assessed Lcn-2 levels both in serum and in the supernatant of short-term cultured renal macrophages (MΦ) as well as renal tubular epithelial cells (TEC) isolated from either Sham-operated or cecal ligation and puncture (CLP)-treated septic mice. Total kidney iron content was analyzed by Perls’ staining, while Lcn-2-bound iron in the supernatants of short-term cultured cells was determined by atomic absorption spectroscopy. Lcn-2 protein in serum was rapidly up-regulated at 6 h after sepsis induction and subsequently increased up to 48 h. Lcn-2-levels in the supernatant of TEC peaked at 24 h and were low at 48 h with no change in its iron-loading. In contrast, in renal MΦ Lcn-2 was low at 24 h, but increased at 48 h, where it mainly appeared in its iron-bound form. Whereas TEC-secreted, iron-free Lcn-2 was associated with renal injury, increased MΦ-released iron-bound Lcn-2 was linked to renal recovery. Therefore, we hypothesized that both the cellular source of Lcn-2 as well as its iron-load crucially adds to its biological function during sepsis-induced renal injury.
Background Polypharmacy interventions are resource-intensive and should be targeted to those at risk of negative health outcomes. Our aim was to develop and internally validate prognostic models to predict health-related quality of life (HRQoL) and the combined outcome of falls, hospitalisation, institutionalisation and nursing care needs, in older patients with multimorbidity and polypharmacy in general practices.
Methods Design: two independent data sets, one comprising health insurance claims data (n=592 456), the other data from the PRIoritising MUltimedication in Multimorbidity (PRIMUM) cluster randomised controlled trial (n=502). Population: ≥60 years, ≥5 drugs, ≥3 chronic diseases, excluding dementia. Outcomes: combined outcome of falls, hospitalisation, institutionalisation and nursing care needs (after 6, 9 and 24 months) (claims data); and HRQoL (after 6 and 9 months) (trial data). Predictor variables in both data sets: age, sex, morbidity-related variables (disease count), medication-related variables (European Union-Potentially Inappropriate Medication list (EU-PIM list)) and health service utilisation. Predictor variables exclusively in trial data: additional socio-demographics, morbidity-related variables (Cumulative Illness Rating Scale, depression), Medication Appropriateness Index (MAI), lifestyle, functional status and HRQoL (EuroQol EQ-5D-3L). Analysis: mixed regression models, combined with stepwise variable selection, 10-fold cross validation and sensitivity analyses.
Results Most important predictors of EQ-5D-3L at 6 months in best model (Nagelkerke’s R² 0.507) were depressive symptoms (−2.73 (95% CI: −3.56 to −1.91)), MAI (−0.39 (95% CI: −0.7 to −0.08)), baseline EQ-5D-3L (0.55 (95% CI: 0.47 to 0.64)). Models based on claims data and those predicting long-term outcomes based on both data sets produced low R² values. In claims data-based model with highest explanatory power (R²=0.16), previous falls/fall-related injuries, previous hospitalisations, age, number of involved physicians and disease count were most important predictor variables.
Conclusions Best trial data-based model predicted HRQoL after 6 months well and included parameters of well-being not found in claims. Performance of claims data-based models and models predicting long-term outcomes was relatively weak. For generalisability, future studies should refit models by considering parameters representing well-being and functional status.
Lockdown measures during the COVID-19 pandemic have led to reductions in physical activity (PA) worldwide. Leading public health organizations have recommended the use of online exercise classes (OEC) to compensate the loss of regular exercise classes. As of now, no data are available on the uptake of OEC and on users’ attitudes. The aim of the current online survey was to assess the use of and attitudes towards OEC in Germany. Respondents indicated awareness and use of OEC, and levels of agreement with statements on OEC. Frequency of awareness and use of OEC according to PA status were calculated with contingency tables and the Χ2 test. Differences between users and non-users were tested with the Student’s t-test and the Mann–Whitney U test. Data on attitudes are presented as percentages, and Spearman correlations were calculated between attitudes and activity status, frequency of use, educational attainment, age and body mass index. A total of 979 datasets were analyzed. Of the respondents, 681 were aware of and 180, 118 and 84 used them <1 per week, 1–2 per week and ≥3 per week, respectively. Significantly more active respondents were aware of and used OEC compared to less active respondents. All in all, regular OEC use was quite limited. OEC was differentially attractive to people according to PA status, frequency of use, BMI and age. Tailoring OEC to current non-users and adding motivational support might enhance the regular use of OEC.
Introduction: Obesity is classified as a global epidemic and judged to be the greatest public health threat in Western countries. The tremendously increasing prevalence rates in children lead to morbidity and mortality in adults. In many countries, prevalence has doubled since the 1980s. Other countries show a continuous increase or stagnate at a very high level. Given these regional differences, this study aims to draw a global world map of childhood obesity research, including regional epidemiological characteristics, to comprehensively assess research influences and needs. Methods: In addition to established bibliometric parameters, this study uses epidemiological data to interpret metadata on childhood obesity research from the Web of Science in combination with state-of-the-art visualization methods, such as density equalizing map projections. Results: It was not until the 1990s that belated recognition of the dangerous effects of childhood obesity led to an increase in the number of publications worldwide. In addition, our findings show that countries’ study output does not correlate with epidemiologic rates of childhood obesity. In contrast, the primary driver of the research efforts on childhood obesity appears to be largely driven government funding structures. Discussion/Conclusion: The geographical differences in the epidemiological background of childhood obesity complicate the implementation of transnational research projects and cross-border prevention programs. Effective realization requires a sound scientific basis, which is facilitated by globally valid approaches. Hence, there is a need for information exchange between researchers, policy makers, and private initiatives worldwide.
Hematopoietic stem cell transplantation (HSCT) has been proposed as a promising therapeutic opportunity to improve immunity and prevent hematologic malignancies in Ataxia-telangiectasia (A-T). However, experience in the transplantation strategy for A-T patients is still scarce. The aim of this study was to investigate whether different approaches of HSCT are feasible in regard to graft versus host response and sufficient concerning functional immune reconstitution. Atm-deficient mice were treated with a clinically relevant non-myeloablative host-conditioning regimen and transplanted with CD90.2-depleted, green fluorescent protein (GFP)-expressing, and ataxia telangiectasia mutated (ATM)-competent bone marrow donor cells in a syngeneic, haploidentical or allogeneic setting. Like syngeneic HSCT, haploidentical HSCT, but not allogeneic HSCT extended the lifespan of Atm-deficient mice through the reduction of thymic tumors and normalized T-cell numbers. Donor-derived splenocytes isolated from transplanted Atm-deficient mice filled the gap of cell loss in the naïve T-cell population and raised CD4 cell functionality up to wild-type level. Interestingly, HSCT using heterozygous donor cells let to a significantly improved survival of Atm-deficient mice and increased CD4 cell numbers as well as CD4 cell functionality equivalent to HSCT using with wild-type donor cells. Our data provided evidence that haploidentical HSCT could be a feasible strategy for A-T, possibly even if the donor is heterozygous for ATM. However, this basic research cannot substitute any research in humans.
Introduction: Ischemic and hemorrhagic strokes in the brainstem and cerebellum with injury to the functional loop of the Guillain-Mollaret triangle (GMT) can trigger a series of events that result in secondary trans-synaptic neurodegeneration of the inferior olivary nucleus. In an unknown percentage of patients, this leads to a condition called hypertrophic olivary degeneration (HOD). Characteristic clinical symptoms of HOD progress slowly over months and consist of a rhythmic palatal tremor, vertical pendular nystagmus, and Holmes tremor of the upper limbs. Diffusion Tensor Imaging (DTI) with tractography is a promising method to identify functional pathway lesions along the cerebello-thalamo-cortical connectivity and to generate a deeper understanding of the HOD pathophysiology. The incidence of HOD development following stroke and the timeline of clinical symptoms have not yet been determined in prospective studies—a prerequisite for the surveillance of patients at risk. Methods and Analysis: Patients with ischemic and hemorrhagic strokes in the brainstem and cerebellum with a topo-anatomical relation to the GMT are recruited within certified stroke units of the Interdisciplinary Neurovascular Network of the Rhine-Main. Matching lesions are identified using a predefined MRI template. Eligible patients are prospectively followed up and present at 4 and 8 months after the index event. During study visits, a clinical neurological examination and brain MRI, including high-resolution T2-, proton-density-weighted imaging, and DTI tractography, are performed. Fiberoptic endoscopic evaluation of swallowing is optional if palatal tremor is encountered. Study Outcomes: The primary endpoint of this prospective clinical multicenter study is to determine the frequency of radiological HOD development in patients with a posterior fossa stroke affecting the GMT at 8 months after the index event. Secondary endpoints are identification of (1) the timeline and relevance of clinical symptoms, (2) lesion localizations more prone to HOD occurrence, and (3) the best MR-imaging regimen for HOD identification. Additionally, (4) DTI tractography data are used to analyze individual pathway lesions. The aim is to contribute to the epidemiological and pathophysiological understanding of HOD and hereby facilitate future research on therapeutic and prophylactic measures.
Background: To test the value of immunohistochemistry (IHC) staining in prostate biopsies for changes in biopsy results and its impact on treatment decision-making. Methods: Between January 2017–June 2020, all patients undergoing prostate biopsies were identified and evaluated regarding additional IHC staining for diagnostic purpose. Final pathologic results after radical prostatectomy (RP) were analyzed regarding the effect of IHC at biopsy. Results: Of 606 biopsies, 350 (58.7%) received additional IHC staining. Of those, prostate cancer (PCa) was found in 208 patients (59.4%); while in 142 patients (40.6%), PCa could be ruled out through IHC. IHC patients harbored significantly more often Gleason 6 in biopsy (p < 0.01) and less suspicious baseline characteristics than patients without IHC. Of 185 patients with positive IHC and PCa detection, IHC led to a change in biopsy results in 81 (43.8%) patients. Of these patients with changes in biopsy results due to IHC, 42 (51.9%) underwent RP with 59.5% harboring ≥pT3 and/or Gleason 7–10. Conclusions: Patients with IHC stains had less suspicious characteristics than patients without IHC. Moreover, in patients with positive IHC and PCa detection, a change in biopsy results was observed in >40%. Patients with changes in biopsy results partly underwent RP, in which 60% harbored significant PCa.
The entorhino-dentate projection, i.e., the perforant pathway, terminates in a highly ordered and laminated fashion in the rodent dentate gyrus (DG): fibers arising from the medial entorhinal cortex (MEC) terminate in the middle molecular layer, whereas fibers arising from the lateral entorhinal cortex (LEC) terminate in the outer molecular layer of the DG. In rats and rabbits, a crossed entorhino-dentate projection exists, which originates from the entorhinal cortex (EC) and terminates in the contralateral DG. In contrast, in mice, such a crossed projection is reportedly absent. Using single and double mouse organotypic entorhino-hippocampal slice cultures, we studied the ipsi- and crossed entorhino-dentate projections. Viral tracing revealed that entorhino-dentate projections terminate with a high degree of lamina-specificity in single as well as in double cultures. Furthermore, in double cultures, entorhinal axons arising from one slice freely intermingled with entorhinal axons originating from the other slice. In single as well as in double cultures, entorhinal axons exhibited a correct topographical projection to the DG: medial entorhinal axons terminated in the middle and lateral entorhinal axons terminated in the outer molecular layer. Finally, entorhinal neurons were virally transduced with Channelrhodopsin2-YFP and stimulated with light, revealing functional connections between the EC and dentate granule cells. We conclude from our findings that entorhino-dentate projections form bilaterally in the mouse hippocampus in vitro and that the mouse DG provides a permissive environment for crossed entorhinal fibers.
Invasive fungal disease (IFD) in hematopoietic stem cell transplantation is associatedwith high morbidity and mortality. As the antifungal host response determines risk and outcomeof IFD, there is growing interest in adoptive immunotherapy using T cells or natural killer (NK)cells. Although the NK-92 cell line has been tested as anticancer therapy in clinical trials, data onthe antifungal activity of NK-92 cells are lacking. Here, we show that the NK-92 cell line exhibitsconsiderable fungal damage on all medically important fungi tested, such as different species ofAspergillus,Candida, mucormycetes, andFusarium. The extent of fungal damage differs acrossvarious species of mucormycetes andFusarium, whereas it is comparable across different species ofAspergillusandCandida. Interferon (IFN)-γlevels in the supernatant were lower when NK-92 cells areco-incubated withAspergillus fumigatus,Candida albicans, orRhizopus arrhizuscompared to the levelswhen NK-92 cells are incubated alone. Different to primary human NK cells, no increase of perforinlevels in the supernatant was observed when the fungi were added to NK-92 cells. Ourin vitrodatademonstrated that the NK-92 cell line could be a feasible tool for antifungal immunotherapy, butdata of animal models are warranted prior to clinical trials.
The aim of the current study was to analyze two major pitfalls in forensic entomological casework: delayed evidence sampling and the effect of low-temperature storage of the body. For this purpose, temperature profiles of heavily infested corpses during cooling and cases in which insect evidence was collected both at the scene and during autopsy were evaluated with regard to species composition and development stages found. The results show that the temperature in the body bags remained at higher average temperatures up to 10 °C relative to the mortuary cooler, therefore, sufficient for larval development, with significant differences in temperature between larval aggregations on one and the same body. In addition, we found large differences both in species number, species composition, and the developmental stages found at the scene and during the autopsy. These data and observations underscore the importance of sampling evidence at the scene and recording temperatures throughout the cooling period of a body.
Background: We conducted a comprehensive medication review at the patients’ home, using data from electronic patient records, and with input from relevant specialists, general practitioners and pharmacists formulated and implemented recommendations to optimize medication use in patients aged 60+ years with polypharmacy. We evaluated the effect of this medication review on quality of life (QoL) and medication use. Methods: Cluster randomized controlled trial (stepped wedge), randomly assigning general practices to one of three consecutive steps. Patients received usual care until the intervention was implemented. Primary outcome was QoL (SF-36 and EQ-5D); secondary outcomes were medication changes, medication adherence and (instrumental) activities of daily living (ADL, iADL) which were measured at baseline, and around 6- and 12-months post intervention. Results: Twenty-four general practices included 360 women and 410 men with an average age of 75 years (SD 7.5). A positive effect on SF-36 mental health (estimated mean was stable in the intervention, but decreased in the control condition with −6.1, p = 0.009,) was found with a reduced number of medications at follow-up compared to the control condition. No significant effects were found on other QoL subscales, ADL, iADL or medication adherence. Conclusion: The medication review prevented decrease of mental health (SF36), with no significant effects on other outcome measures, apart from a reduction in the number of prescribed medications.
Despite recent advances in the treatment of colorectal cancer (CRC), patient’s individual response and clinical follow-up vary considerably with tumor intrinsic factors to contribute to an enhanced malignancy and therapy resistance. Among these markers, upregulation of members of the inhibitor of apoptosis protein (IAP) family effects on tumorigenesis and radiation- and chemo-resistance by multiple pathways, covering a hampered induction of apoptosis/autophagy, regulation of cell cycle progression and DNA damage response. These mechanisms are tightly controlled by the tumor suppressor p53 and thus transcriptional and post-translational regulation of IAPs by p53 is expected to occur in malignant cells. By this, cellular IAP1/2, X-linked IAP, Survivin, BRUCE and LIVIN expression/activity, as well as their intracellular localization is controlled by p53 in a direct or indirect manner via modulating a multitude of mechanisms. These cover, among others, transcriptional repression and the signal transducer and activator of transcription (STAT)3 pathway. In addition, p53 mutations contribute to deregulated IAP expression and resistance to therapy. This review aims at highlighting the mechanistic and clinical importance of IAP regulation by p53 in CRC and describing potential therapeutic strategies based on this interrelationship.
The estimation of the minimum time since death is one of the main applications of forensic entomology. This can be done by calculating the age of the immature stage of necrophagous flies developing on the corpse, which is confined to approximately 2–4 weeks, depending on temperature and species of the first colonizing wave of flies. Adding the age of the adult flies developed on the dead body could extend this time frame up to several weeks when the body is in a building or closed premise. However, the techniques for accurately estimating the age of adult flies are still in their beginning stages or not sufficiently validated. Here we review the current state of the art of analysing the aging of flies by evaluating the ovarian development, the amount of pteridine in the eyes, the degree of wing damage, the modification of their cuticular hydrocarbon patterns, and the increasing number of growth layers in the cuticula. New approaches, including the use of age specific molecular profiles based on the levels of gene and protein expression and the application of near infrared spectroscopy, are introduced, and the forensic relevance of these methods is discussed.
Chronic intestinal failure (CIF) is a rare but feared complication of Crohn’s disease. Depending on the remaining length of the small intestine, the affected intestinal segment, and the residual bowel function, CIF can result in a wide spectrum of symptoms, from single micronutrient malabsorption to complete intestinal failure. Management of CIF has improved significantly in recent years. Advances in home-based parenteral nutrition, in particular, have translated into increased survival and improved quality of life. Nevertheless, 60% of patients are permanently reliant on parenteral nutrition. Encouraging results with new drugs such as teduglutide have added a new dimension to CIF therapy. The outcomes of patients with CIF could be greatly improved by more effective prevention, understanding, and treatment. In complex cases, the care of patients with CIF requires a multidisciplinary approach involving not only physicians but also dietitians and nurses to provide optimal intestinal rehabilitation, nutritional support, and an improved quality of life. Here, we summarize current literature on CIF and short bowel syndrome, encompassing epidemiology, pathophysiology, and advances in surgical and medical management, and elucidate advances in the understanding and therapy of CIF-related complications such as catheter-related bloodstream infections and intestinal failure-associated liver disease.
Introduction: Surgical practices constitute a common topic of complaint among medical students. The aim of this study is to analyze the type of surgical training that students receive in medical school and the impact of SARS-CoV-2 pandemic.
Methods: A survey based on the National Spanish Agency for the Quality of Evaluation and Accreditation (ANECA) guidelines was spread on social media between medical students and physicians waiting to start their residency. The time spent in surgical practices, the number of times that certain abilities were performed, and the desire of choosing a surgical specialty were analyzed.
Results: 1053 surveys were analyzed. Significant differences between the number of months that students rotate and the number of procedures performed as they gained seniority were found. A weak positive correlation between the number of months rotating and the number of procedures performed was found. The desire of choosing a surgical specialty was not associated with the time spent in surgical practice. SARS-CoV-2 pandemic has reduced the time spent in surgical practice and some of the surgical procedures performed.
Conclusion: The amount of surgical procedures performed by students is below the requirements of ANECA guidelines. A different level of dexterity between 6th year students’ group affected by SARS-CoV-2 pandemic and physicians’ group should not be expected because of the low number of procedures performed by both groups. Students’ role in the operating room and the need for different systems of skills learning should be reconsidered.
Background: Rates of permanent pacemaker implantation (PPI) have been low using the self‐expanding ACURATE neo device, but data regarding risk factors of PPI for this specific device are scarce.
Methods: The study cohort consisted of patients (n = 1000) with severe aortic stenosis undergoing transfemoral transcatheter aortic valve implantation (TAVI) using the ACURATE neo prosthesis in our center between May 2012 and December 2019. For the present analysis, we excluded patients with previous permanent pacemaker (n = 110), high‐grade AV block prior to TAVI (n = 3), and patients requiring conversion to surgical valve replacement (n = 4) or the implantation of a second prosthesis as valve‐in‐valve (n = 15). Preexisting conduction abnormalities were determined, and the implantation depth of the prosthesis was measured on final angiography. Differences across quartiles based on the original consecutive cohort were analyzed with respect to implantation depth and PPI rate. Predictors of PPI were identified using logistic regression.
Results: The PPI rate was 10%. Preexisting AV block I°, right bundle branch block (RBBB), and the implantation depth were independent predictors of PPI. Across quartiles, the implantation depth differed significantly with lowest values in the last quartile, whereas differences of PPI rates across quartiles were not statistically significant, but showed a notable decrease in the last quartile.
Conclusion: Preexisting RBBB, AV block I°, and low implantation depth were independent predictors of PPI following TAVI using the ACURATE neo device. Instead of deliberately aiming at a high position, avoidance of a low implantation depth may represent a reasonable compromise to reduce the rate of PPI without increasing the risk of malpositioning.
Background: The aim of this study was to evaluate post‐irradiation changes in the central nervous system (CNS) detected using magnetic resonance (MR) imaging.
Methods: Magnetic resonance images of 15 children with CNS tumors treated through whole‐brain irradiation over 10 years were reviewed retrospectively. Variables such as age at the time of irradiation, total radiation dose, treatment length, and time interval between irradiation and MR changes, were evaluated.
Results: All patients included in the study had imaging abnormalities of the CNS. Eight patients (53%) developed CNS abnormalities within a short period of time – only a few months after irradiation (mean 4.8 months). Seven patients (47%) developed CNS abnormalities within a long time interval after treatment (mean 4.6 years). In almost all patients, a T2 increase in supra‐ and infratentorial white matter was observed. Follow‐up examinations showed nine patients (60%) with cerebellar atrophy.
Conclusions: In this sample of pediatric patients who underwent whole‐brain irradiation, the time receiving irradiation was not related to the severity of the MR changes. A correlation between the age of the child or the length of the radiotherapy and the extent of the changes could not be confirmed. However, we observed a trend towards stronger brain parenchymal degeneration with cystic changes in the younger age group of children in our sample. Older children who received irradiation seem to be more susceptible to vascular dysplasia with cavernous hemangiomas and microbleeding.
Background: Conditions during blood product storage and transportation should maintain quality. The aim of this in vitro study was to investigate the effect of interruption of agitation, temporary cooling (TC), and pneumatic tube system transportation (PTST) on the aggregation ability (AA) and mitochondrial function (MF) of platelet concentrates (PC).
Study Design and Methods: A PC was divided equally into four subunits and then allocated to four test groups. The control group (I) was stored as recommended (continuous agitation, 22 ± 2°C) for 4 days. The test groups were stored without agitation (II), stored as recommended, albeit 4°C for 60 minutes on day (d)2 (III) and PTST (IV). Aggregometry was measured using Multiplate (RocheAG; ADPtest, ASPItest, TRAPtest, COLtest) and MF using Oxygraph‐2k (Oroboros Instruments). The basal and maximum mitochondrial respiratory rate (MMRR) were determined. AA and MF were measured daily in I and II and AA in III and IV on d2 after TC/PTST. Statistical analysis was performed using tests for matched observations.
Results: Eleven PCs were used. TRAP‐6 induced AA was significantly lower in II when compared to I on d4 (P = 0.015*). In III the ASPItest was significantly lower (P = 0.032*). IV showed no significant differences. The basal and MMRR were significantly reduced over 4 days in I and II (for both rates in both groups: P = <0.0001*). No significant differences occurred on d4 (P = 0.495).
Conclusion: Our results indicate that ex vivo AA and MF of PCs are unaffected, even in no‐ideal storage and transport circumstances with respect to agitation, temperature, and force.
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that is accompanied by neurodevelopmental differences in regional cortical volume (CV), and a potential layer‐specific pathology. Conventional measures of CV, however, do not indicate how volume is distributed across cortical layers. In a sample of 92 typically developing (TD) controls and 92 adult individuals with ASD (aged 18–52 years), we examined volumetric gradients by quantifying the degree to which CV is weighted from the pial to the white surface of the brain. Overall, the spatial distribution of Frustum Surface Ratio (FSR) followed the gyral and sulcal pattern of the cortex and approximated a bimodal Gaussian distribution caused by a linear mixture of vertices on gyri and sulci. Measures of FSR were highly correlated with vertex‐wise estimates of mean curvature, sulcal depth, and pial surface area, although none of these features explained more than 76% variability in FSR on their own. Moreover, in ASD, we observed a pattern of predominant increases in the degree of FSR relative to TD controls, with an atypical neurodevelopmental trajectory. Our findings suggest a more outward‐weighted gradient of CV in ASD, which may indicate a larger contribution of supragranular layers to regional differences in CV.
Studies over the past decade have revealed that metabolism profoundly influences immune responses. In particular, metabolism causes epigenetic regulation of gene expression, as a growing number of metabolic intermediates are substrates for histone post-translational modifications altering chromatin structure. One of these substrates is acetyl-coenzyme A (CoA), which donates an acetyl group for histone acetylation. Cytosolic acetyl-CoA is also a critical substrate for de novo synthesis of fatty acids and sterols necessary for rapid cellular growth. One of the main enzymes catalyzing cytosolic acetyl-CoA formation is ATP-citrate lyase (ACLY). In addition to its classical function in the provision of acetyl-CoA for de novo lipogenesis, ACLY contributes to epigenetic regulation through histone acetylation, which is increasingly appreciated. In this review we explore the current knowledge of ACLY and acetyl-CoA in mediating innate and adaptive immune responses. We focus on the role of ACLY in supporting de novo lipogenesis in immune cells as well as on its impact on epigenetic alterations. Moreover, we summarize alternative sources of acetyl-CoA and their contribution to metabolic and epigenetic regulation in cells of the immune system.