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We have analyzed a series of eleven mutations in the 49-kDa protein of mitochondrial complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica to identify functionally important domains in this central subunit. The mutations were selected based on sequence homology with the large subunit of [NiFe] hydrogenases. None of the mutations affected assembly of complex I, all decreased or abolished ubiquinone reductase activity. Several mutants exhibited decreased sensitivities toward ubiquinone-analogous inhibitors. Unexpectedly, seven mutations affected the properties of iron-sulfur cluster N2, a prosthetic group not located in the 49-kDa subunit. In three of these mutants cluster N2 was not detectable by electron-paramagnetic resonance spectroscopy. The fact that the small subunit of hydrogenase is homologous to the PSST subunit of complex I proposed to host cluster N2 offers a straightforward explanation for the observed, unforeseen effects on this iron-sulfur cluster. We propose that the fold around the hydrogen reactive site of [NiFe] hydrogenase is conserved in the 49-kDa subunit of complex I and has become part of the inhibitor and ubiquinone binding region. We discuss that the fourth ligand of iron-sulfur cluster N2 missing in the PSST subunit may be provided by the 49-kDa subunit.
We consider J/ψ production in heavy ion collisions at RHIC energies in the statistical coalescence model with exact (canonical ensemble) charm conservation. Charm quark–antiquark pairs are assumed to be created in primary hard parton collisions, but open and hidden charm particles are formed at the hadronization stage according to the laws of statistical mechanics. The dependence of the J/ψ production on both the number of nucleon participants and the collision energy is studied. The model predicts J/ψ suppression for low energies, whereas at the highest RHIC energy the model reveals J/ψ enhancement.
For statistical multifragmentation model the critical indices α′,β,γ′,δ are calculated as functions of the Fisher parameter τ. It is found that these indices have different values than in Fisher's droplet model. Some peculiarities of the scaling relations are discussed. The basic model predicts for the index τ a narrow range of values, 1.799<τ<1.846, which is consistent with two experiments on nuclear multifragmentation.
In high energy p(p)+p interactions the mean multiplicity and transverse mass spectra of neutral mesons from η to ϒ (m≅0.5–10 GeV/c2) and the transverse mass spectra of pions (mT> 1 GeV/c2) reveal a remarkable behaviour: they follow, over more than 10 orders of magnitude, the power-law function: Cm(T)−P. The parameters C and P are energy dependent, but similar for all mesons produced at the same collision energy. This scaling resembles that expected in the statistical description of hadron production: the parameter P plays the role of a temperature and the normalisation constant C is analogous to the system volume. The fundamental difference is, however, in the form of the distribution function. In order to reproduce the experimental results and preserve the basic structure of the statistical approach the Boltzmann factor e−E∗/T appearing in standard statistical mechanics has to be substituted by a power-law factor (E∗/Λ)−P.
O propósito deste artigo é o de expor os motivos que levaram T.W. Adorno e M. Horkheimer a não tratar o problema filosófico da moral nas sociedades contemporâneas nos termos de uma teoria ética. Em decorrência disso, a ética assume, na perspectiva desses autores, a dimensão de um impulso que se realiza enquanto crítica racional a uma racionalidade supostamente esclarecida.
Aquest article intenta exposar els temes centrals de la teoria estètica de T.W. Adorno a través dels seus assajos sobre música. Partint dels problemes que es plantegen a l’anàlisi de la composició a Schönberg i Stravinsky, es tracta la relació entre art i filosofia, així com la seva concepció de la composició, la duplicitat del fet artístic i la seva importància com a corrector de la racionalitat instrumental.
Crustal structure at the western end of the North Anatolian Fault Zone from deep seismic sounding
(2001)
The first deep seismic sounding experiment in Northwestern Anatolia was carried out in October 1991 as part of the "German - Turkish Project on Earthquake Prediction Research" in the Mudurnu area of the North Anatolian Fault Zone. The experiment was a joint enterprise by the Institute of Meteorology and Geophysics of Frankfurt University, the Earthquake Research Institute (ERI) in Ankara, and the Turkish Oil Company (TPAO). Two orthogonal profiles, each 120 km in length with a crossing point near Akyazi, were covered in succession by 30 short period tape recording seismograph stations with 2 km station spacing. 12 shots, with charge sizes between 100 and 250 kg, were fired and 342 seismograms out of 360 were used for evaluation. By coincidence an M b = 4.5 earthquake located below Imroz Island was also recorded and provided additional information on Moho and the sub-Moho velocity. A ray tracing method orginally developed by Weber (1986) was used for travel time inversion. From a compilation of all data two generalized crustal models were derived, one with velocity gradients within the layers and one with constant layer velocities. The latter consists of a sediment cover of about 2 km with V p » 3.6 km/s, an upper crystalline crust down to 13 km with V p » 5.9 km/s, a middle crust down to 25 km depth with V p » 6.5 km/s, a lower crust down to 39 km Moho depth with V p » 7.0 km/s and V p » 8.05 km/s below the Moho. The structure of the individual profiles differs slightly. The thickest sediment cover is reached in the Izmit-Sapanca-trough and in the Akyazi basin. Of particular interest is a step of about 4 km in the lower crust near Lake Sapanca and probably an even larger one in the Moho (derived from the Imroz earthquake data). After the catastrophic earthquake of Izmit on 17 August 1999 this significant heterogeneity in crustal structure appears in a new light with regard to the possible cause of the Izmit earthquake. Heterogeneities in structure are frequently also heterogeneities in strength and stress that impede or even lock rupture. The Izmit earthquake is discussed in relation to a large stepover or jog at the North Anatolian Fault.
The present study is the second in a three-part series (the first appearing in <i>Sefarad </i>59 [1999] pp. 3-42; the third being in press) on the phenomenon of Neo- Latin and Romance-Language —Spanish and Portuguese— poetry of the Sephardim in Hamburg and Frankfurt am Main from the early seventeenth to the midnineteenth centuries. Our collection expands the original poetic corpus from twenty-eight to forty-five works. In an historical and critical Introduction to the poems, the authors distinguish the creative genius of a new type of literary discourse, one which meshes neo-classical strophic forms with inspiration from Sephardic orthodox Judaism as it was practiced in the Dutch Netherlands, biblical events and Jewish philosophical constructs. In addition to the evaluation and edition of the poems and, in the cases of Neo-Latin works, their translation to English, the Introduction includes an argument for substantiating book printing of Sephardic-authored books in Frankfurt am Main during the period 1614-1634 as well as sporadically throughout the remainder of the seventeenth century.<br><br>Nuestro estudio representa la segunda parte (la primera apareció en <i>Sefarad</i> 59 [1999] págs. 3-42; la tercera está en prensa) de un trabajo sobre la poesía en latín y lenguas romances —español y portugués— de los sefardíes de Hamburgo y de Frankfurt am Main desde principios del siglo XVII hasta mediados del XVIII. Aquí el <i>corpus poetarum</i> se amplía de veintiocho a cuarenta y cinco obras; estas nuevas poesías evidencian un espíritu neoclasicista mezclado ingeniosamente con un discurso apegado a un judaísmo ortodoxo-sefardí tal como entonces se practicaba en los países protestantes del norte de Europa. En el apartado introductorio, que es tanto descriptivo como evaluativo de la obra poética, se defiende la tesis de que la ciudad protestante de Frankfurt am Main con su feria del libro anual servía como lugar de impresión para ciertas obras producidas por autores sefardíes durante los años 1614-1632 y esporádicamente durante el resto del siglo XVII.