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Higher N170 amplitudes to words and to faces were recently reported for faster readers of German. Since the shallow German orthography allows phonological recoding of single letters, the reported speed advantages might have their origin in especially well-developed visual processing skills of faster readers. In contrast to German, adult readers of Hebrew are forced to process letter chunks up to whole words. This dependence on more complex visual processing might have created ceiling effects for this skill. Therefore, the current study examined whether also in the deep Hebrew orthography visual processing skills as reflected by N170 amplitudes explain reading speed differences. Forty university students, native speakers of Hebrew without reading impairments, accomplished a lexical decision task (i.e., deciding whether a visually presented stimulus represents a real or a pseudo word) and a face decision task (i.e., deciding whether a face was presented complete or with missing facial features) while their electroencephalogram was recorded from 64 scalp positions. In both tasks stronger event related potentials (ERPs) were observed for faster readers in time windows at about 200 ms. Unlike in previous studies, ERP waveforms in relevant time windows did not correspond to N170 scalp topographies. The results support the notion of visual processing ability as an orthography independent marker of reading proficiency, which advances our understanding about regular and impaired reading development.
The reading acceleration phenomenon refers to the effect that experimentally induced time constraints can generate instantaneous improvements of reading rate, accuracy and comprehension among typical and reading impaired readers of different age groups. An overview of studies applying the fading manipulation (i.e., letters are erased in reading direction), which induces the time constraints causing the acceleration phenomenon, is provided in the first part of this review. The second part summarises the outcomes of studies using a training approach called the reading acceleration program (RAP) that integrated core principles of the acceleration phenomenon to generate persistent reading performance improvements. Our review shows ample evidence for the validity of the acceleration phenomenon, since it has been replicated across various languages and populations. However, although there are several explanatory approaches for underlying mechanisms, none of them is well substantiated by empirical evidence so far. Similarly, although generally positive effects of RAP training were reported for several languages and groups of readers, the exact mechanisms causing improved reading rates and comprehension are not well understood. Our critical discussion points out several limitations of RAP that call for further research. However, we also highlight several benefits regarding RAP's potential as an intervention approach for enhancements in reading performance. Video abstract link: https://youtu.be/wO6aEXavk8w
Previous reports of improved oral reading performance for dyslexic children but not for regular readers when between-letter spacing was enlarged led to the proposal of a dyslexia-specific deficit in visual crowding. However, it is in this context also critical to understand how letter spacing affects visual word recognition and reading in unimpaired readers. Adopting an individual differences approach, the present study, accordingly, examined whether wider letter spacing improves reading performance also for non-impaired adults during silent reading and whether there is an association between letter spacing and crowding sensitivity. We report eye movement data of 24 German students who silently read texts presented either with normal or wider letter spacing. Foveal and parafoveal crowding sensitivity were estimated using two independent tests. Wider spacing reduced first fixation durations, gaze durations, and total fixation time for all participants, with slower readers showing stronger effects. However, wider letter spacing also reduced skipping probabilities and elicited more fixations, especially for faster readers. In terms of words read per minute, wider letter spacing did not provide a benefit, and faster readers in particular were slowed down. Neither foveal nor parafoveal crowding sensitivity correlated with the observed letter-spacing effects. In conclusion, wide letter spacing reduces single word processing time in typically developed readers during silent reading, but affects reading rates negatively since more words must be fixated. We tentatively propose that wider letter spacing reinforces serial letter processing in slower readers, but disrupts parallel processing of letter chunks in faster readers. These effects of letter spacing do not seem to be mediated by individual differences in crowding sensitivity.
Anaphylactic shock is a severe allergic reaction involving multiple organs including the bronchial and cardiovascular system. Most anaphylactic mediators, like platelet-activating factor (PAF), histamine, and others, act through G protein – coupled receptors, which are linked to the heterotrimeric G proteins Gq /G 11 , G12/G13 , and Gi . The role of downstream signaling pathways activated by anaphylactic mediators in defi ned organs during anaphylactic reactions is largely unknown. Using genetic mouse models that allow for the conditional abrogation of G q /G 11 - and G 12 /G 13 -mediated signaling pathways by inducible Cre/loxP-mediated mutagenesis in endothelial cells (ECs), we show that Gq /G11 -mediated signaling in ECs is required for the opening of the endothelial barrier and the stimulation of nitric oxide formation by various infl ammatory mediators as well as by local anaphylaxis. The systemic effects of anaphylactic mediators like histamine and PAF, but not of bacterial lipopolysaccharide (LPS), are blunted in mice with endothelial G alpha q/G alpha 11 deficiency. Mice with endothelium-specific G alpha q /G alpha 11 deficiency, but not with G alpha 12/G alpha 13 deficiency, are protected against the fatal consequences of passive and active systemic anaphylaxis. This identifies endothelial Gq/G11 -mediated signaling as a critical mediator of fatal systemic anaphylaxis and, hence, as a potential new target to prevent or treat anaphylactic reactions.
This article parts from an interdisciplinary point of view. Its main interest lies in the rich and complex interaction between the literary text and the image. These relations are understood as a “reciprocal illumination between the arts”, according to a publication of Oskar Walzel (Berlin, 1917). It will first investigate two historical landmarks in relation to literature and the image: first, the social differentiation around 1800 and its imposition of a purely textual literature and second, the avant-garde with its intense interaction between the various forms of artistic communication. The paper will then approach two contemporary examples of novels which combine visual and textual material.
Este artigo reavalia a fase literária pop do escritor suíço Christian Kracht em relação aos seus últimos dois romances históricos. A superfície, ou até a superficialidade, talvez explique a ênfase da literatura pop dos anos 1990 em labels, servindo apenas como enumeração de elementos concretos, sem jamais entrar no abstrato. Argumentamos, quando nos referimos a Christian Kracht, que ele abandona tais tendências com seus últimos dois romances, "Imperium", de 2012, e "Os mortos", de 2017, sem, entretanto, renunciar à ambivalência entre o superficial e o profundo, pois ele foge habilmente de qualquer posição unívoca, tanto na forma narrativa em seus romances, quanto na forma extraliterária em entrevistas ou informações biográficas. Em virtude disso, há incertezas e ambiguidades quanto a um suposto "núcleo" autêntico ou verdadeiro de sua obra, sendo impossível distinguir claramente entre a teatralidade ficcional e a não-ficcional.
This article conceives the avant-garde as a form of art that emerges out of the experience with technical progress, city life and new patterns of perception and that succeeded in transforming multiple perspective and simultaneity of urban life into a central principle for their production. Analyzed are the European avant-gardes as well as their influences on Brazilian literature and painting in the 20s. Furthermore we take a look at concrete poetry of the 50's as a literary pendant to architectonic concepts of cities like São Paulo and Brasília.
O presente artigo objetiva abordar a obra e vida de Karl May, um dos mais bem-sucedidos escritores de língua alemã, sob o aspecto da encenação. Mostra como May mistura lembranças da infância e elementos literários, o desejado e o factual para uma memória encenada, que fornece um sentido mais profundo tanto para sua biografia como para sua obra. Assim, May se recria como homem ideal que consegue em seus romances superar seus problemas com a realidade, um "eu" multifacetado representado por suas diversas personagens literárias e suas aventuras, reclamadas por May como experiências próprias. Se os entrecruzamentos da identidade ficcional e pessoal criados por Karl May marcam a primeira fase de sua produção e se formamem volta do motivo do aprisionamento e da libertação, sua obra tardia se abstém de tais elementos e se dirige a uma reflexão quase filosófica sobre a humanidade e a paz.v
This article will provide a general look on modern literature as partially configured by medial history. It parts from the impact of Gutenberg’s invention on social differentiation and the romantic literary concepts, and then looks on photography as an important reference for the realistic aesthetics as well as the initial struggle of film against the domination of the traditional literary medium. It closes with a brief historical overview on what one may call precursors of the hyperlink in literary communication.