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The shortage of functional information compared to the abundance of sequence information characterizes today’s situation in functional genomics. For many years the knock-down of a gene’s product has been the most powerful way of analysing its function. In addition to the complete knock-out by homologous recombination, several different techniques have been developed to temporarily knock down gene expression through methods based on specific sequence recognition, such as knockdown by antisense oligonucleotides, ribozymes, aptamers or RNAi.
The ESF workshop on ‘Impact of Nucleic Acid Chemistry on Gene Function Analysis’ brought together researchers who use techniques that are different but highly related. It offered an opportunity for an in-depth discussion of recent progress and common problems. Antisense oligonucleotides aptamers and ribozymes are techniques that have been used successfully for many years to validate targets. However, recent developments, such as increased tightness of binding (e.g. locked nucleic acids) or the combination of different methods (e.g. using aptamers to design ribozymes), have continued to improve the existing techniques. RNA interference (RNAi) is a defence mechanism of the cell against viruses. Since the exact mechanism of action within the cell is still unclear, RNAi was a particularly exciting topic at the workshop and was addressed in the largest number of presentations. Predictability of positional effects (accessibility of RNA) is a problem shared by all techniques using sequence-specific recognition and was the subject of quite controversial debates.
The meeting comprised over 50 people from 14 countries (13 European countries and the USA).
„Das Reich geht mich nichts an“ : Goethes Götz von Berlichingen, das Reich und die Reichspublizistik
(2002)
Der folgende Beitrag soll zeigen, dass die Reichsreformbemühungen um 1500 und die Forma imperii-Debatte des 17. Jahrhunderts neben politischen Fragen des späten 18. Jahrhunderts den historischen und politisch-theoretische Hintergrund für Goethes Schauspiel „Götz von Berlichingen mit der eisernen Hand“ bilden. In dem Drama fin-den sich zwei entgegengesetzte Interpretationen der Reichsverfassung. Diese sind so-wohl bestimmten Figuren des Dramas sowie nacheinander folgenden Zeiten der deut-schen Geschichte zuzuordnen. Bei der Umsetzung benutzte Goethe verschiedene For-men der Zeitenmontage. Themen des 18. Jahrhunderts werden zum Gegenstand einer Handlung, die zu Beginn des 16. Jahrhunderts spielt. Das 17. Jahrhundert, in dem die Reichspublizistik die Frage der Forma imperii, der Staatsform des Reiches, intensiv erörterte, sparte Goethe dabei aus. Deswegen wird die Forma imperii-Debatte in einem zweiten Teil nochmals anhand ihrer Hauptexponenten skizziert. Hierbei wird deutlich, dass die Frontstellung der Berli-chingenzeit, nämlich die Frage Lehensverband oder Staatsbildung, in der zweiten Hälfte des 17. Jahrhunderts bereits so überholt war, wie mit Beginn des 18. Jahrhunderts auch die Frage nach der Staatsform des Reiches. Die Zeit, über die Goethe schreibt, die Jahre um 1500, und die Zeit, in der er schreibt, im letzten Drittel des 18. Jahrhunderts, um-schließen als Anfangs- und Endphase die Epoche des frühmodernen Staates. Dieser wird sowohl im Geschichtsdrama wie in diesem Beitrag betrachtet. In diesem Kontext wird auch auf die aktuelle Debatte um den Charakter des alten Reiches eingegangen. In einem dritten Teil soll der Götz-Stoff als Teil der Reichspublizistik vorgestellt werden. Hier geht es auch um die nationale Dimension des Götz-Dramas und sein Bezug zur Reichspolitik.
Im Sommer 2001 wurden käferkundliche Exkursionen in verschiedenen Regionen Mitteleuropas sowie des angrenzenden Südostens durchgeführt. Ausser zahlreichen Neu- und Wiederfunden für die jeweilige Region gelang mit Pseudolathra manueli (Staphylinidae, Paederinae) auch ein Neufund für Deutschland. Im östlichen Ungarn wurde mehrfach eine noch nicht beschriebene Staphyliniden-Art der Gattung Atheta (U.G.Parameotica) gefunden.
Am 1. November 2002 erschien die 3. Ausgabe des SNUDEBILLER, der weltweit ersten digitalen Fachzeitschrift zur Taxonomie, Biologie und Ökologie der Rüsselkäfer auf CD ROM. Der Rezensent hat lange gewartet und die Entwicklung des SNUDEBILLER-Reaktionsteams im CURCULIO-Institut in den letzten drei Jahren aufmerksam beobachtet, bevor er sich jetzt an eine erste Bestandsaufnahme wagt.
Der Beitrag geht davon aus, dass es von den Anfängen bis heute eigentlich keine deutsche Einheitssprache gegeben hat, sondern nur regionale Varietäten. Auch wenn Regionalität bei den Sprachen eine universale Kategorie zu sein scheint, zählt das Deutsche aus einer Reihe soziokultureller und sprachhistorischer Gründe zu den Sprachen, in denen den Varietäten eine besondere Bedeutung zukommt: Deutsch ließe sich wohl als ein Prototyp für die Heterogenität innerhalb einer Sprache ansehen. Der Aufsatz spricht von einer „mehrfachen Regionalität“ der deutschen Gegenwartssprache, die sich zugleich in mehreren diatopischen Variationsdimensionen manifestiert. Gemäß der variationslinguistischen Dialektologie – die primär den Aufbau und den Wandel des gesamten Spektrums regionaler Sprachvariation zwischen den Extremen Standardsprache und Basisdialekt erforscht – handelt es sich im vorliegenden Beitrag nicht um Schichten bzw. Strata, sondern um Oppositionen, d.h. um eine Art „Skala“ mit den beiden Polen („Standardsprache“ vs. andere Varietät), in deren Spannungsfeld sich die Kulturrealität Variation abspielt. In diesem Sinne werden der Standardsprache folgende Oppositionsdimensionen gegenübergestellt: (a) (z.B. groß- und kleinräumige bzw. lokale) Basisdialekte, (b) regionale Umgangssprachen, (c) nationale Standardvarietäten des Deutschen im Rahmen des Konzepts „Deutsch als plurizentrische Sprache“ und (d) Deutsch als Minderheitensprache im Sinne einer dialektalen Kontaktvarietät.
A cladistic analysis is presented of the hawkmoths of the tribe Acherontiini, Morgan´s Sphinx (Xanthopan morganii (Walker», and related genera. The study aims to test the monophyly of tribe Acherontiini; the hypothesis that all taxa with extremely long probosces (some Acherontiini, Meganoton rubescens, Neococytius, Xanthopan) form a monophyletic group, or at least fall within a single reasonably compact clade; and, within this group, to determine whether Xanthopan is more closely related to Acherontiini or to COCytillS and Neococytius. The data set comprises 109 characters derived from adult and immature stage morphology, biology and behaviour. These data were analysed using equal weighting, successive approximations character weighting (SACW) and implied weighting. All weighting schemes agreed on the monophyly of Acherontiini and of a group of genera comprising Amphimoea, Cocytius and Neococytius (the Cocytius group). Several other generic and suprageneric clades were also consistently recovered. However, those hawkmoths with extremely long probosces were never recovered as a monophyletic group. The relationships of Xanthopan were also ambiguous. Equal weighting and SACW placedXanthopan + Meganoton rztbescens (Butler) as sister to the COCytills group, while implied weighting placed Xanthopan as sister to Acherontiini. This latter relationship is based primarily on shared possession of a pilifer/palp hearing organ. Further analyses suggested the two components of this organ were not biologically independent. Downweighting this feature accordingly resulted in all weighting schemes converging on the topology found by equal weighting. Exclusion of the incomplete subset of immature stage data had no effect under implied weighting but equal weighting and SACW now recovered a Neotropical clade comprising Manduca. and the Cocytius group, while Xanthopan was placed with M. rubescens and Panogena. Downweighting the pilifer/palp hearing organ under implied weighting again caused convergence with the equal weighting/SACW results. Thus, the relationships of Xanthopan remain equivocal and further data, particularly from the immature stages, will be required to elucidate its phylogenetic position further.
In this paper I seek to account for the productive word-formation process resulting in the current proliferation of un-nouns, the semi-legitimate offspring of Humpty Dumpty´s un-birthday present (1871) and 7-Up´s commercial incarnation as The Un-Cola (1968), a construction that can be linked to the more well-established categories of un-adjectives and un-verbs, whose formation constraints we will also examine. Drawing on a large corpus of novel un-nouns I have assembled in collaboration with Beth Levin presented in the Appendices to this paper, I will invoke Rosch´s prototype semantics and Aristotle´s notion of PRIVATIVE opposites, defined in terms of a marked exception to a general class property, to generalize across the different categories of un-words. It will be argued that a given un-noun refers either to an element just outside a given category with whose members it shares a salient function (e.g. un-cola) or to a peripheral member of a given category (an unhotel is a hotel but not a good exemplar of the class-not a HOTEL hotel).
The Siwalik formations of northern Pakistan consist of deposits of ancient rivers that existed throughout the early Miocene through the late Pliocene. The formations are highly fossiliferous with a diverse array of terrestrial and freshwater vertebrates, which in combination with exceptional lateral exposure and good chronostratigraphic control allows a more detailed and temporally resolved study of the sediments and faunas than is typical in terrestrial deposits. Consequently the Siwaliks provide an opportunity to document temporal differences in species richness, turnover, and ecological structure in a terrestrial setting, and to investigate how such differences are related to changes in the fluvial system, vegetation, and climate. Here we focus on the interval between 10.7 and 5.7 Ma, a time of significant local tectonic and global climatic change. It is also the interval with the best temporal calibration of Siwalik faunas and most comprehensive data on species occurrences. A methodological focus of this paper is on controlling sampling biases that confound biological and ecological signals. Such biases include uneven sampling through time, differential preservation of larger animals and more durable skeletal elements, errors in age-dating imposed by uncertainties in correlation and paleomagnetic timescale calibrations, and uneven taxonomic treatment across groups. We attempt to control for them primarily by using a relative-abundance model to estimate limits for the first and last appearances from the occurrence data. This model also incorporates uncertainties in age estimates. Because of sampling limitations inherent in the terrestrial fossil record, our 100-Kyr temporal resolution may approach the finest possible level of resolution for studies of vertebrate faunal changes over periods of millions of years. Approximately 40,000 specimens from surface and screenwash collections made at 555 localities form the basis of our study. Sixty percent of the localities have maximum and minimum age estimates differing by 100 Kyr or less, 82% by 200 Kyr or less. The fossils represent 115 mammalian species or lineages of ten orders: Insectivora, Scandentia, Primates, Tubulidentata, Proboscidea, Pholidota, Lagomorpha, Perissodactyla, Artiodactyla, and Rodentia. Important taxa omitted from this study include Carnivora, Elephantoidea, and Rhinocerotidae. Because different collecting methods were used for large and small species, they are treated separately in analyses. Small species include insectivores, tree shrews, rodents, lagomorphs, and small primates. They generally weigh less than 5 kg. The sediments of the study interval were deposited by coexisting fluvial systems, with the larger emergent Nagri system being displaced between 10.1 and 9.0 Ma by an interfan Dhok Pathan system. In comparison to Nagri floodplains, Dhok Pathan floodplains were less well drained, with smaller rivers having more seasonally variable flow and more frequent avulsions. Paleosol sequences indicate reorganization of topography and drainage accompanying a transition to a more seasonal climate. A few paleosols may have formed under waterlogged, grassy woodlands, but most formed under drier conditions and more closed vegetation. The oxygen isotopic record also indicates significant change in the patterns of precipitation beginning at 9.2 Ma, in what may have been a shift to a drier and more seasonal climate. The carbon isotope record demonstrates that after 8.1 Ma significant amounts of C4 grasses began to appear and that by 6.8 Ma floodplain habitats included extensive C4 grasslands. Plant communities with predominantly C3 plants were greatly diminished after 7.0 Ma, and those with predominantly C4 plants, which would have been open woodlands or grassy woodlands, appeared as early as 7.4 Ma. Inferred first and last appearances show a constant, low level of faunal turnover throughout the interval 10.7–5.7-Ma, with three short periods of elevated turnover at 10.3, 7.8, and 7.3–7.0 Ma. The three pulses account for nearly 44% of all turnover. Throughout the late Miocene, species richness declined steadily, and diversity and richness indices together with data on body size imply that community ecological structure changed abruptly just after 10 Ma, and then again at 7.8 Ma. Between 10 and 7.8 Ma the large-mammal assemblages were strongly dominated by equids, with more balanced faunas before and after. The pattern of appearance and disappearance is selective with respect to inferred habits of the animals. Species appearing after 9.0 Ma are grazers or typical of more open habitats, whereas many species that disappear can be linked to more closed vegetation. We presume exceptions to this pattern were animals of the mixed C3/C4 communities or the wetter parts of the floodplain that did not persist into the latest Miocene. The pace of extinction accelerates once there is C4 vegetation on the floodplain. The 10.3 Ma event primarily comprises disappearance of taxa that were both common and of long duration. The event does not correlate to any obvious local environmental or climatic event, and the pattern of species disappearance and appearance suggests that biotic interactions may have been more important than environmental change. The 7.8 Ma event is characterized solely by appearances, and that at 7.3 Ma by a combination of appearances and disappearances. These two latest Miocene events include more taxa that were shorter ranging and less common, a difference of mode that developed between approximately 9.0 and 8.5 Ma when many short-ranging and rare species began to make appearances. Both events also show a close temporal correlation to changes in floodplain deposition and vegetation. The 7.8 Ma event follows the widespread appearance of C4 vegetation and is coincident with the shift from equid-dominated to more evenly balanced large-mammal assemblages. The 7.3 to 7.0 Ma event starts with the first occurrence of C4-dominated floras and ends with the last occurrence of C3-dominated vegetation. Absence of a consistent relationship between depositional facies and the composition of faunal assemblages leads us to reject fluvial system dynamics as a major cause of faunal change. The close correlation of latest Miocene species turnover and ecological change to expansion of C4 plants on the floodplain, in association with oxygen isotopic and sedimentological evidence for increasingly drier and more seasonal climates, causes us to favor explanations based on climatic change for both latest Miocene pulses. The Siwalik record supports neither “coordinated stasis” nor “turnover pulse” evolutionary models. The brief, irregularly spaced pulses of high turnover are characteristic of both the stasis and pulse models, but the high level of background turnover that eliminates 65–70% of the initial species shows there is no stasis in the Siwalik record. In addition, the steadily declining species richness and abrupt, uncoordinated changes in diversity do not fit either model.