Fluid overload is associated with increased 90-day mortality in AML patients undergoing induction chemotherapy

  • Treatment‐related complications contribute substantially to morbidity and mortality in acute myeloid leukemia (AML) patients undergoing induction chemotherapy. Although AML patients are susceptible to fluid overload (FO) (e.g., in the context of chemotherapy protocols, during sepsis treatment or to prevent tumor lysis syndrome), little attention has been paid to its role in AML patients undergoing induction chemotherapy. AML patients receiving induction chemotherapy between 2014 and 2019 were included in this study. FO was defined as ≥5% weight gain on day 7 of induction chemotherapy compared to baseline weight determined on the day of admission. We found FO in 23 (12%) of 187 AML patients undergoing induction chemotherapy. Application of >100 ml crystalloid fluids/kg body weight until day 7 of induction chemotherapy was identified as an independent risk factor for FO. AML patients with FO suffered from a significantly increased 90-day mortality rate and FO was demonstrated as an independent risk factor for 90-day mortality. Our data suggests an individualized, weight-adjusted calculation of crystalloid fluids in order to prevent FO-related morbidity and mortality in AML patients during induction chemotherapy. Prospective trials are required to determine the adequate fluid management in this patient population.

Download full text files

Export metadata

Author:Olivier Karl Friedrich BalloORCiDGND, Fagr EladlyGND, Sebastian E. KoschadeORCiDGND, Stefan BüttnerGND, Jan Alexander StratmannORCiDGND, Uta BrunnbergGND, Eva-Maria Kreisel, Franziska FrankGND, Sebastian WagnerORCiDGND, Björn SteffenGND, Hubert ServeORCiDGND, Fabian FinkelmeierORCiDGND, Christian Hubertus BrandtsORCiDGND
Parent Title (English):Annals of hematology
Place of publication:Berlin ; Heidelberg ; New York
Document Type:Article
Date of Publication (online):2021/07/25
Date of first Publication:2021/07/25
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/03/03
Tag:Acute myeloid leukemia; Fluid overload; Induction chemotherapy; Intensive care treatment; Survival
Page Number:9
First Page:2603
Last Page:2611
Open Access funding enabled and organized by Projekt DEAL.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0