Controlling coagulation in blood with red light

Precise control of blood clotting and rapid reversal of anticoagulation are essential in many clinical situations. We were successful in modifying a thrombin-binding aptamer with a red-light photocleavable linker derived from Cy7 by Cu-catalyzed Click chemistry. We were able to show that we can successfully deactivate the modified aptamer with red light (660 nm) even in human blood—restoring the blood's natural coagulation capability.

Metadaten
Author:	Patricia Müller, Marlen Sahlbach, Simone Gasper, Günter Mayer, Jens Müller ORCiD, Bernd Pötzsch, Alexander Heckel ORCiD
URN:	urn:nbn:de:hebis:30:3-639396
DOI:	https://doi.org/10.1002/anie.202108468
ISSN:	1521-3773
Parent Title (English):	Angewandte Chemie
Publisher:	Wiley-VCH
Place of publication:	Weinheim
Document Type:	Article
Language:	English
Date of Publication (online):	2021/07/22
Date of first Publication:	2021/07/22
Publishing Institution:	Universitätsbibliothek Johann Christian Senckenberg
Release Date:	2022/03/22
Tag:	aptamer; oligonucleotide; photocaging; phototherapeutic window; red light
Volume:	60
Issue:	41
Page Number:	6
First Page:	22441
Last Page:	22446
Note:	This work was funded by the Deutsche Forschungsgemeinschaft (SFB 902, GRK 1986). Open access funding enabled and organized by Projekt DEAL.
HeBIS-PPN:	493370730
Institutes:	Biochemie, Chemie und Pharmazie
Dewey Decimal Classification:	5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
	6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:	Universitätspublikationen
Licence (German):	Creative Commons - Namensnennung 4.0

Open Access