Gamma-rhythmic gain modulation

  • Cognition requires the dynamic modulation of effective connectivity, i.e., the modulation of the postsynaptic neuronal response to a given input. If postsynaptic neurons are rhythmically active, this might entail rhythmic gain modulation, such that inputs synchronized to phases of high gain benefit from enhanced effective connectivity. We show that visually induced gamma-band activity in awake macaque area V4 rhythmically modulates responses to unpredictable stimulus events. This modulation exceeded a simple additive superposition of a constant response onto ongoing gamma-rhythmic firing, demonstrating the modulation of multiplicative gain. Gamma phases leading to strongest neuronal responses also led to shortest behavioral reaction times, suggesting functional relevance of the effect. Furthermore, we find that constant optogenetic stimulation of anesthetized cat area 21a produces gamma-band activity entailing a similar gain modulation. As the gamma rhythm in area 21a did not spread backward to area 17, this suggests that postsynaptic gamma is sufficient for gain modulation.

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Author:Ni JianguangORCiDGND, Thomas WunderleORCiDGND, Christopher Murphy LewisORCiD, Robert DesimoneORCiD, Ilka DiesterORCiDGND, Pascal FriesORCiDGND
Parent Title (English):Neuron
Publisher:Cell Press
Place of publication:[Cambridge, Mass.]
Document Type:Article
Date of Publication (online):2016/09/22
Date of first Publication:2016/09/22
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2023/04/23
Page Number:17
First Page:240
Last Page:251
Institutes:Angeschlossene und kooperierende Institutionen / MPI f├╝r Hirnforschung
Dewey Decimal Classification:1 Philosophie und Psychologie / 15 Psychologie / 150 Psychologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0