Proteoglycan form and function: a comprehensive nomenclature of proteoglycans
- We provide a comprehensive classification of the proteoglycan gene families and respective protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores. These three signatures were utilized to design four major classes of proteoglycans with distinct forms and functions: the intracellular, cell-surface, pericellular and extracellular proteoglycans. The proposed nomenclature encompasses forty-three distinct proteoglycan-encoding genes and many alternatively-spliced variants. The biological functions of these four proteoglycan families are critically assessed in development, cancer and angiogenesis, and in various acquired and genetic diseases where their expression is aberrant.
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| Author: | Renato V. IozzoORCiDGND, Liliana SchäferORCiD |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-534334 |
| DOI: | https://doi.org/10.1016/j.matbio.2015.02.003 |
| ISSN: | 0945-053X |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/25701227 |
| Parent Title (English): | Matrix Biology |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam [u.a.] |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2015/02/18 |
| Date of first Publication: | 2015/02/18 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2020/05/12 |
| Volume: | 42 |
| Page Number: | 45 |
| First Page: | 11 |
| Last Page: | 55 |
| Note: | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| HeBIS-PPN: | 466007159 |
| Institutes: | Medizin / Medizin |
| Fachübergreifende Einrichtungen / Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit (ZAFES) | |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |
