The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1)
- The UDP-glucose ceramide glycosyltransferase (UGCG) is a key enzyme in the sphingolipid metabolism by generating glucosylceramide (GlcCer), the precursor for all glycosphingolipids (GSL), which are essential for proper cell function. Interestingly, the UGCG is also overexpressed in several cancer types and correlates with multidrug resistance protein 1 (MDR1) gene expression. This membrane protein is responsible for efflux of toxic substances and protects cancer cells from cell damage through chemotherapeutic agents. Studies showed a connection between UGCG and MDR1 overexpression and multidrug resistance development, but the precise underlying mechanisms are unknown. Here, we give an overview about the UGCG and its connection to MDR1 in multidrug resistant cells. Furthermore, we focus on UGCG transcriptional regulation, the impact of UGCG on cellular signaling pathways and the effect of UGCG and MDR1 on the lipid composition of membranes and how this could influence multidrug resistance development. To our knowledge, this is the first review presenting an overview about UGCG with focus on the relationship to MDR1 in the process of multidrug resistance development.
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| Author: | Marthe-Susanna WegnerORCiDGND, Lisa GruberGND, Peter MattjusORCiD, Gerd GeisslingerORCiDGND, Sabine GröschORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-456796 |
| DOI: | https://doi.org/10.1186/s12885-018-4084-4 |
| ISSN: | 1471-2407 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/29409484 |
| Parent Title (English): | BMC cancer |
| Publisher: | BioMed Central ; Springer |
| Place of publication: | London ; Berlin ; Heidelberg |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2018 |
| Date of first Publication: | 2018/02/06 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2018/02/15 |
| Tag: | Cancer; Glycosphingolipids; MDR1; Multidrug resistance; P-gp; UDP-glucose ceramide glycosyltransferase; UGCG |
| Volume: | 18 |
| Issue: | 1, Art. 153 |
| Page Number: | 10 |
| First Page: | 1 |
| Last Page: | 10 |
| Note: | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| HeBIS-PPN: | 427822092 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 4.0 |
