Stephan Kolodziej, Olga Nikolaevna Lausen, Thomas Oellerich, Julia Herglotz, Ingo Backert, Nicole Kohrs, Estella Buscató Arsequell, Sandra Kerstin Wittmann, Gabriela Salinas-Riester, Halvard-Björn Bönig, Michael Karas, Hubert Serve, Ewgenij Proschak, Jörn Lausen
- The transcription factor Tal1 is a critical activator or repressor of gene expression in hematopoiesis and leukaemia. The mechanism by which Tal1 differentially influences transcription of distinct genes is not fully understood. Here we show that Tal1 interacts with the peptidylarginine deiminase IV (PADI4). We demonstrate that PADI4 can act as an epigenetic coactivator through influencing H3R2me2a. At the Tal1/PADI4 target gene IL6ST the repressive H3R2me2a mark triggered by PRMT6 is counteracted by PADI4, which augments the active H3K4me3 mark and thus increases IL6ST expression. In contrast, at the CTCF promoter PADI4 acts as a repressor. We propose that the influence of PADI4 on IL6ST transcription plays a role in the control of IL6ST expression during lineage differentiation of hematopoietic stem/progenitor cells. These results open the possibility to pharmacologically influence Tal1 in leukaemia.
MetadatenAuthor: | Stephan Kolodziej, Olga Nikolaevna Lausen, Thomas OellerichORCiD, Julia Herglotz, Ingo Backert, Nicole Kohrs, Estella Buscató Arsequell, Sandra Kerstin Wittmann, Gabriela Salinas-Riester, Halvard-Björn BönigORCiDGND, Michael KarasGND, Hubert ServeORCiDGND, Ewgenij ProschakORCiDGND, Jörn Lausen |
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URN: | urn:nbn:de:hebis:30:3-373900 |
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DOI: | https://doi.org/10.1038/ncomms4995 |
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ISSN: | 2041-1723 |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/24874575 |
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Parent Title (English): | Nature Communications |
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Publisher: | Nature Publishing Group |
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Place of publication: | London |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2014/05/29 |
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Date of first Publication: | 2014/05/29 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2015/10/08 |
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Volume: | 5 |
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Issue: | 3995 |
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Page Number: | 12 |
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First Page: | 1 |
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Last Page: | 12 |
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Note: | This work is licensed under a Creative Commons Attribution- NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons. org/licenses/by-nc-nd/3.0/ |
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HeBIS-PPN: | 37144845X |
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Institutes: | Biochemie, Chemie und Pharmazie / Pharmazie |
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| Medizin / Medizin |
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| Angeschlossene und kooperierende Institutionen / Georg-Speyer-Haus |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0 |
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