Tobias A. Bauer, Natalie Horvat, Oriana Marques, Sara Chocarro, Christina Mertens, Silvia Colucci, Sascha Schmitt, Luca M. Carrella, Svenja Winzen, Kaloian Koynov, Federico Fenaroli, Peter Blümler, Michaela Jung, Rocio Sotillo, Matthias W. Hentze, Martina Muckenthaler, Matthias Barz
- Iron is an essential co-factor for cellular processes. In the immune system, it can activate macrophages and represents a potential therapeutic for various diseases. To specifically deliver iron to macrophages, iron oxide nanoparticles are embedded in polymeric micelles of reactive polysarcosine-block-poly(S-ethylsulfonyl-l-cysteine). Upon surface functionalization via dihydrolipoic acid, iron oxide cores act as crosslinker themselves and undergo chemoselective disulfide bond formation with the surrounding poly(S-ethylsulfonyl-l-cysteine) block, yielding glutathione-responsive core cross-linked polymeric micelles (CCPMs). When applied to primary murine and human macrophages, these nanoparticles display preferential uptake, sustained intracellular iron release, and induce a strong inflammatory response. This response is also demonstrated in vivo when nanoparticles are intratracheally administered to wild-type C57Bl/6N mice. Most importantly, the controlled release concept to deliver iron oxide in redox-responsive CCPMs induces significantly stronger macrophage activation than any other iron source at identical iron levels (e.g., Feraheme), directing to a new class of immune therapeutics.
MetadatenAuthor: | Tobias A. BauerORCiD, Natalie HorvatORCiDGND, Oriana MarquesORCiDGND, Sara ChocarroORCiD, Christina MertensORCiDGND, Silvia ColucciORCiDGND, Sascha Schmitt, Luca M. CarrellaORCiD, Svenja WinzenORCiDGND, Kaloian KoynovORCiD, Federico Fenaroli, Peter Blümler, Michaela JungORCiD, Rocio SotilloORCiDGND, Matthias W. HentzeORCiDGND, Martina MuckenthalerORCiDGND, Matthias BarzORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-722909 |
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DOI: | https://doi.org/10.1002/adhm.202100385 |
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ISSN: | 2192-2659 |
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Parent Title (English): | Advanced healthcare materials |
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Publisher: | Wiley-VCH |
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Place of publication: | Weinheim |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2021/06/16 |
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Date of first Publication: | 2021/06/16 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2023/04/27 |
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Tag: | cross-linking; iron metabolism; macrophage polarization; polymeric micelle; polypept(o)ide; superparamagnetic iron oxide nanoparticles |
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Volume: | 10 |
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Issue: | 19, art. 2100385 |
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Article Number: | 2100385 |
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Page Number: | 13 |
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First Page: | 1 |
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Last Page: | 13 |
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HeBIS-PPN: | 508540879 |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
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| 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
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| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International |
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