Severe traumatic brain injury (TBI) modulates the kinetic profile of the inflammatory response of markers for neuronal damage
- The inflammatory response plays an important role in the pathophysiology of multiple injuries. This study examines the effects of severe trauma and inflammatory response on markers of neuronal damage. A retrospective analysis of prospectively collected data in 445 trauma patients (Injury Severity Score (ISS) ≥ 16) is provided. Levels of neuronal biomarkers (calcium-binding Protein B (S100b), Enolase2 (NSE), glial fibrillary acidic protein (GFAP)) and Interleukins (IL-6, IL-10) in severely injured patients (with polytrauma (PT)) without traumatic brain injury (TBI) or with severe TBI (PT+TBI) and patients with isolated TBI (isTBI) were measured upon arrival until day 5. S100b, NSE, GFAP levels showed a time-dependent decrease in all cohorts. Their expression was higher after multiple injuries (p = 0.038) comparing isTBI. Positive correlation of marker level after concomitant TBI and isTBI (p = 0.001) was noted, while marker expression after PT appears to be independent. Highest levels of IL-6 and -10 were associated to PT und lowest to isTBI (p < 0.001). In all groups pro-inflammatory response (IL-6/-10 ratio) peaked on day 2 and at a lower level on day 4. Severe TBI modulates kinetic profile of inflammatory response by reducing interleukin expression following trauma. Potential markers for neuronal damage have a limited diagnostic value after severe trauma because undifferentiated increase.
Author: | Cora Rebecca SchindlerORCiDGND, Thomas LustenbergerORCiDGND, Mathias WoschekGND, Philipp StörmannORCiDGND, Dirk HenrichORCiDGND, Peter Radermacher, Ingo MarziORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-555762 |
DOI: | https://doi.org/10.3390/jcm9061667 |
ISSN: | 2077-0383 |
Parent Title (English): | Journal of Clinical Medicine |
Publisher: | MDPI |
Place of publication: | Basel |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2020/06/01 |
Date of first Publication: | 2020/06/01 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2020/09/23 |
Tag: | GFAP; IL-10; IL-6; NSE; S100b; biomarker; multiple trauma; posttraumatic inflammation; risk prediction; traumatic brain injury (TBI) |
Volume: | 9 |
Issue: | (6), article 1667 |
Page Number: | 13 |
HeBIS-PPN: | 470773847 |
Institutes: | Medizin / Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung 4.0 |