Circulating leukotriene b4 identifies respiratory complications after trauma
- Background. Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker in predicting pulmonary complications (PC) in multiply traumatized patients. Methods: Plasma levels of LTB4 were determined in 100 patients on admission (ED) and for five consecutive days (daily). Twenty healthy volunteers served as control. LTB4-levels were measured by ELISA. Thirty patients developed PC (pneumonia, respiratory failure, acute lung injury (ALI), ARDS, pulmonary embolism) and 70 had no PC (ØPC). Results. LTB4-levels in the PC-group [127.8 pg/mL, IQR: 104–200pg/ml] were significantly higher compared to the ØPC-group on admission [95.6 pg/mL, IQR: 55–143 pg/mL] or control-group [58.4 pg/mL, IQR: 36–108 pg/mL]. LTB4 continuously declined to basal levels from day 1 to 5 without differences between the groups. The cutoff to predict PC was calculated at 109.6 pg/mL (72% specificity, 67% sensitivity). LTB4 was not influenced by overall or chest injury severity, age, gender or massive transfusion. Patients with PC received mechanical ventilation for a significantly longer period of time, and had prolonged intensive care unit and overall hospital stay. Conclusion. High LTB4-levels indicate risk for PC development in multiply traumatized patients
Verfasserangaben: | Birgit AunerGND, Emanuel Valentin Geiger, Dirk HenrichORCiDGND, Mark LehnertGND, Ingo MarziORCiDGND, Borna ReljaORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-247989 |
DOI: | https://doi.org/10.1155/2012/536156 |
ISSN: | 1466-1861 |
ISSN: | 0962-9351 |
Pubmed-Id: | https://pubmed.ncbi.nlm.nih.gov/22529525 |
Titel des übergeordneten Werkes (Englisch): | Mediators of inflammation |
Verlag: | Hindawi Publishing Corp. |
Verlagsort: | Sylvania, Ohio |
Dokumentart: | Wissenschaftlicher Artikel |
Sprache: | Englisch |
Jahr der Fertigstellung: | 2012 |
Jahr der Erstveröffentlichung: | 2012 |
Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Datum der Freischaltung: | 31.05.2012 |
Jahrgang: | Volume 2012 (2012) |
Ausgabe / Heft: | Article ID 536156 |
Seitenzahl: | 8 |
HeBIS-PPN: | 357311949 |
Institute: | Medizin / Medizin |
DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Lizenz (Deutsch): | Creative Commons - Namensnennung 3.0 |