Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila
- The repeated and improper use of antibiotics had led to an increased number of multiresistant bacteria. Therefore, new lead structures are needed. Here, the synthesis and an expanded structure–activity relationship of the simple and antistaphylococcal amide nematophin from Xenorhabdus nematophila and synthetic derivatives are described. Moreover, the synthesis of intrinsic fluorescent derivatives, incorporating azaindole moieties was achieved for the first time.
Author: | Frank WescheORCiD, Hélène Adihou, Thomas Alexander WichelhausORCiD, Helge Björn BodeORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-488112 |
DOI: | https://doi.org/10.3762/bjoc.15.47 |
ISSN: | 1860-5397 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/30873237 |
Parent Title (English): | Beilstein journal of organic chemistry |
Publisher: | Beilstein-Institut zur Förderung der Chemischen Wissenschaften |
Place of publication: | Frankfurt, Main |
Contributor(s): | J. S. Dickschat |
Document Type: | Article |
Language: | English |
Year of Completion: | 2019 |
Date of first Publication: | 2019/02/25 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2019/04/02 |
Tag: | MRSA; Staphylococcus aureus; azaindole; fluorescent dye; nematophin |
Volume: | 15 |
Page Number: | 7 |
First Page: | 535 |
Last Page: | 541 |
Note: | This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc) |
HeBIS-PPN: | 447589326 |
Institutes: | Biowissenschaften / Biowissenschaften |
Medizin / Medizin | |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung 4.0 |