Cholesterol-crystal embolism presenting with delayed graft function and impaired long-term function in renal transplant recipients : two case reports
- Introduction Impaired renal function and/or pre-existing atherosclerosis in the deceased donor increase the risk of delayed graft function and impaired long-term renal function in kidney transplant recipients. Case presentation We report delayed graft function occurring simultaneously in two kidney transplant recipients, aged 57-years-old and 39-years-old, who received renal allografts from the same deceased donor. The 62-year-old donor died of cardiac arrest during an asthmatic state. Renal-allograft biopsies performed in both kidney recipients because of delayed graft function revealed cholesterol-crystal embolism. An empiric statin therapy in addition to low-dose acetylsalicylic acid was initiated. After 10 and 6 hemodialysis sessions every 48 hours, respectively, both renal allografts started to function. Glomerular filtration rates at discharge were 26 ml/min/1.73 m2 and 23.9 ml/min/1.73 m2, and remained stable in follow-up examinations. Possible donor and surgical procedure-dependent causes for cholesterol-crystal embolism are discussed. Conclusion Cholesterol-crystal embolism should be considered as a cause for delayed graft function and long-term impaired renal allograft function, especially in the older donor population.
Author: | Rainer U. PliquettORCiDGND, Aida Asbe-Vollkopf, Ernst-Heinrich ScheuermannGND, Elisabeth Gröne, Michael Probst, Helmut GeigerGND, Ingeborg A. HauserGND |
---|---|
URN: | urn:nbn:de:hebis:30-65987 |
DOI: | https://doi.org/10.1186/1752-1947-3-6839 |
Parent Title (English): | Journal of Medical Case Reports |
Document Type: | Article |
Language: | English |
Year of Completion: | 2009 |
Year of first Publication: | 2009 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2009/05/11 |
Volume: | 3 |
Issue: | 6839 |
Note: | © 2009 Pliquett et al; licensee Cases Network Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Source: | Journal of Medical Case Reports 2009, 3:6839 ; doi: 10.1186/1752-1947-3-6839 |
HeBIS-PPN: | 213961474 |
Institutes: | Medizin / Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Licence (German): | ![]() |