Zsolt Ruzsics, Katja Hoffmann, André Riedl, Adalbert Krawczyk, Marek Widera, Helene Sertznig, Leonie Schipper, Valeria Kapper-Falcone, Monika Debreczeny, Wolfgang Ernst, Reingard Grabherr, Hartmut Hengel, Hanna Harant
- Viral infections are a global disease burden with only a limited number of antiviral agents available. Due to newly emerging viral pathogens and increasing occurrence of drug resistance, there is a continuous need for additional therapeutic options, preferably with extended target range. In the present study, we describe a novel antiviral peptide with broad activity against several double-stranded DNA viruses. The 22-mer peptide TAT-I24 potently neutralized viruses such as herpes simplex viruses, adenovirus type 5, cytomegalovirus, vaccinia virus, and simian virus 40 in cell culture models, while being less active against RNA viruses. The peptide TAT-I24 therefore represents a novel and promising drug candidate for use against double-stranded DNA viruses.
Metadaten| Author: | Zsolt Ruzsics, Katja Hoffmann, André Riedl, Adalbert Krawczyk, Marek WideraORCiDGND, Helene Sertznig, Leonie Schipper, Valeria Kapper-Falcone, Monika Debreczeny, Wolfgang Ernst, Reingard Grabherr, Hartmut Hengel, Hanna Harant |
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| URN: | urn:nbn:de:hebis:30:3-570152 |
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| DOI: | https://doi.org/10.3389/fmicb.2020.601555 |
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| ISSN: | 1664-302X |
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| Parent Title (English): | Frontiers in microbiology |
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| Publisher: | Frontiers Media |
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| Place of publication: | Lausanne |
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| Document Type: | Article |
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| Language: | English |
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| Date of Publication (online): | 2020/11/17 |
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| Date of first Publication: | 2020/11/17 |
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| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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| Release Date: | 2020/12/06 |
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| Tag: | adenovirus; antiviral peptide; cytomegalovirus; herpes simplex virus; polyomavirus |
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| Volume: | 11 |
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| Issue: | 601555 |
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| Page Number: | 10 |
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| HeBIS-PPN: | 476955041 |
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| Institutes: | Medizin / Medizin |
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| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
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| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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| Sammlungen: | Universitätspublikationen |
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| Licence (German): |  Creative Commons - Namensnennung 4.0 |
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Creative Commons - Namensnennung 4.0