Structure, assembly and dynamics of H/ACA-Ribonucleoproteins
- H/ACA-RNPs are involved in RNA guided pseudouridylation of rRNAs and snRNAs. In this thesis I reconstituted active and labeled archaeal as well as eukaryotic H/ACA-RNPs and studied the structural dynamics of complex assembly and pseudouridine formation. Single molecule FRET spectroscopy was used as method of analysis to study structure, assembly and dynamics of these important complexes.
Author: | Gerd Werner Günter Hanspach |
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URN: | urn:nbn:de:hebis:30:3-574468 |
Place of publication: | Frankfurt am Main |
Referee: | Martin HengesbachORCiDGND, Harald SchwalbeORCiDGND |
Document Type: | Doctoral Thesis |
Language: | English |
Date of Publication (online): | 2020/12/16 |
Year of first Publication: | 2020 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Granting Institution: | Johann Wolfgang Goethe-Universität |
Date of final exam: | 2020/12/14 |
Release Date: | 2021/01/13 |
Tag: | H/ACA-RNP; Pseudouridine; Pseudouridylation; Ribonucleoproteins; smFRET |
Page Number: | 221 |
HeBIS-PPN: | 474638626 |
Institutes: | Biochemie, Chemie und Pharmazie |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Sammlungen: | Universitätspublikationen |
Licence (German): | Deutsches Urheberrecht |