Vitali Koch, Julia Anna Walburga Abt, Leon David Grünewald, Katrin Eichler, Tommaso D’Angelo, Simon Martin, Moritz Hans Ernst Albrecht, Axel Thalhammer, Christian Booz, Ibrahim Yel, Simon Bernatz, Scherwin Mahmoudi, Marc Harth, Wojciech Derwich, Thomas J. Vogl, Daphne Gray, Tatjana Gruber-Rouh, Georg Jung
- Purpose
To assess the diagnostic value of different imaging modalities in distinguishing systemic vasculitis from other internal and immunological diseases.
Methods
This retrospective study included 134 patients with suspected vasculitis who underwent ultrasound, magnetic resonance imaging (MRI), or 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) between 01/2010 and 01/2019, finally consisting of 70 individuals with vasculitis. The main study parameter was the confirmation of the diagnosis using one of the three different imaging modalities, with the adjudicated clinical and histopathological diagnosis as the gold standard. A secondary parameter was the morphological appearance of the vessel affected by vasculitis.
Results
Patients with systemic vasculitis had myriad clinical manifestations with joint pain as the most common symptom. We found significant correlations between different imaging findings suggestive of vasculitis and the final adjudicated clinical diagnosis. In this context, on MRI, vessel wall thickening, edema, and diameter differed significantly between vasculitis and non-vasculitis groups (p < 0.05). Ultrasound revealed different findings that may serve as red flags in identifying patients with vasculitis, such as vascular occlusion or halo sign (p = 0.02 vs. non-vasculitis group). Interestingly, comparing maximal standardized uptake values from PET/CT examinations with vessel wall thickening or vessel diameter did not result in significant differences (p > 0.05).
Conclusions
We observed significant correlations between different imaging findings suggestive of vasculitis on ultrasound or MRI and the final adjudicated diagnosis. While ultrasound and MRI were considered suitable imaging methods for detecting and discriminating typical vascular changes, 18F-FDG PET/CT requires careful timing and patient selection given its moderate diagnostic accuracy.
MetadatenAuthor: | Vitali KochORCiDGND, Julia Anna Walburga AbtGND, Leon David GrünewaldORCiDGND, Katrin EichlerGND, Tommaso D’Angelo, Simon MartinORCiDGND, Moritz Hans Ernst AlbrechtORCiDGND, Axel Thalhammer, Christian BoozORCiDGND, Ibrahim YelORCiDGND, Simon BernatzORCiDGND, Scherwin MahmoudiGND, Marc HarthORCiDGND, Wojciech DerwichGND, Thomas J. VoglORCiDGND, Daphne Gray, Tatjana Gruber-RouhORCiDGND, Georg JungGND |
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URN: | urn:nbn:de:hebis:30:3-752101 |
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DOI: | https://doi.org/10.1016/j.ejro.2022.100445 |
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ISSN: | 2352-0477 |
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Parent Title (English): | European journal of radiology open |
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Publisher: | Elsevier Science |
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Place of publication: | Amsterdam [u.a.] |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2022/10/12 |
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Date of first Publication: | 2022/10/12 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2024/08/19 |
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Tag: | Diagnostic imaging; Magnetic resonance imaging; Positron emission tomography; Vasculitis |
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Volume: | 9 |
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Issue: | 100445 |
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Article Number: | art. 100445 |
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Page Number: | 8 |
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First Page: | 1 |
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Last Page: | 8 |
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Note: | Gefördert durch den Open-Access-Publikationsfonds der Goethe-Universität |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Open-Access-Publikationsfonds: | Medizin |
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Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
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