The association between intraoperative cell salvage and red blood cell transfusion in cardiac surgery – an observational study in a patient blood management centre
- Introduction: Cell salvage (CS) is an integral part of patient blood management (PBM) and aims to reduce allogeneic red blood cell (RBC) transfusion. Material and methods: This observational study analysed patients scheduled for elective cardiac surgery requiring cardiopulmonary bypass (CPB) between November 2015 and October 2018. Patients were divided into a CS group (patients receiving CS) and a control group (no CS). Primary endpoints were the number of patients exposed to allogeneic RBC transfusions and the number of RBC units transfused per patient. Results: A total of 704 patients undergoing cardiac surgery were analysed, of whom 338 underwent surgery with CS (CS group) and 366 were without CS (control group). Intraoperatively, 152 patients (45%) were exposed to allogeneic RBC transfusions in the CS group and 93 patients (25%) in the control group (P < 0.001). Considering the amount of intraoperative blood loss, regression analysis revealed a significant association between blood loss and increased use of RBC units in patients of the control compared to the CS group (1000 mL: 1.0 vs. 0.6 RBC units; 2000 mL: 2.2 vs. 1.1 RBC units; 3000 mL: 3.4 vs. 1.6 RBC units). Thus, CS was significantly associated with a reduced number of allogeneic RBCs by 40% for 1000 mL, 49% for 2000 mL, and 52% for 3000 mL of blood loss compared to patients without CS. Conclusions: Cell salvage was significantly associated with a reduced number of allogeneic RBC transfusions. It supports the beneficial effect of CS in cardiac surgical patients as an individual measure in a comprehensive PBM program.
Author: | Vanessa NeefORCiDGND, Linda VoGND, Eva HerrmannORCiDGND, Chris TriphausGND, Leonie JuddGND, Andreas WinterORCiD, Kai ZacharowskiORCiDGND, Suma ChoorapoikayilGND, Patrick MeybohmORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-629437 |
DOI: | https://doi.org/10.5114/ait.2021.103735 |
ISSN: | 1731-2531 |
ISSN: | 1642-5758 |
Parent Title (English): | Anaesthesiology intensive therapy |
Publisher: | Medigo |
Place of publication: | Warszawa |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2021/02/23 |
Date of first Publication: | 2021/02/23 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2023/08/23 |
Tag: | cardiac surgery; cell salvage; patient blood management; transfusion |
Volume: | 53 |
Issue: | 1 |
Page Number: | 9 |
First Page: | 1 |
Last Page: | 9 |
Note: | Implementation of the Patient Blood Management program was supported by B. Braun Melsungen, CSL Behring, Fresenius Kabi, and Vifor Pharma. |
HeBIS-PPN: | 511655126 |
Institutes: | Medizin / Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - CC BY-NC-SA - Namensnennung - Nicht kommerziell - Weitergabe unter gleichen Bedingungen 4.0 International |