The role of cGMP and PKG-I in spinal nociceptive processing

  • First paragraph (this article has no abstract) Persistent stimulation of nociceptors results in sensitization of nociceptive sensory neurons, which is associated with hyperalgesia and allodynia. The release of NO and subsequent synthesis of cGMP in the spinal cord are involved in this process. cGMP-dependent protein kinase I (PKG-I) has been suggested to act as a downstream target of cGMP, but its exact role in nociception hadn't been characterized yet. To further evaluate the NO/cGMP/PKG-I pathway in nociception we assessed the effects of PKG-I inhibiton and activaton in the rat formalin assay and analyzed the nociceptive behavior of PKG-I-/- mice. Open access article.

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Author:Achim SchmidtkoORCiDGND, Irmgard TegederORCiDGND, Ellen NiederbergerGND, Franz Hofmann, Peter RuthGND, Gerd GeisslingerORCiDGND
Parent Title (English):BMC pharmacology
Publisher:BioMed Central
Place of publication:London
Document Type:Article
Date of Publication (online):2005/06/22
Date of first Publication:2005/06/16
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Contributing Corporation:2nd International Conference of cGMP Generators, Effectors and Therapeutic Implications, Potsdam, Germany, 10–12 June, 2005
Release Date:2005/06/22
Issue:(Suppl 1):P50
Page Number:1
First Page:1
Last Page:1
Copyright: © BioMed Central Ltd 2005
Source:BMC Pharmacology 2005, 5(Suppl 1):P50 ,
Institutes:Biochemie, Chemie und Pharmazie / Pharmazie
Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoDeutsches Urheberrecht