The plasmodium export element revisited

  • We performed a bioinformatical analysis of protein export elements (PEXEL) in the putative proteome of the malaria parasite Plasmodium falciparum. A protein family-specific conservation of physicochemical residue profiles was found for PEXEL-flanking sequence regions. We demonstrate that the family members can be clustered based on the flanking regions only and display characteristic hydrophobicity patterns. This raises the possibility that the flanking regions may contain additional information for a family-specific role of PEXEL. We further show that signal peptide cleavage results in a positional alignment of PEXEL from both proteins with, and without, a signal peptide.

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Author:Jan Alexander HißORCiDGND, Jude Marek Przyborski, Florian Schwarte, Klaus Lingelbach, Gisbert SchneiderORCiDGND
Parent Title (English):PLoS One
Document Type:Article
Date of Publication (online):2008/02/06
Date of first Publication:2008/02/06
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2008/09/25
Issue:(2): e1560
© 2008 Hiss et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source:PLoS ONE 3(2): e1560. doi:10.1371/journal.pone.0001560
Institutes:Biowissenschaften / Biowissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Sammlungen:Sammlung Biologie / Sondersammelgebiets-Volltexte
Licence (German):License LogoCreative Commons - Namensnennung 3.0