Domain organization of long autotransporter signal sequences

  • Bacterial autotransporters represent a diverse family of proteins that autonomously translocate across the inner membrane of Gram-negative bacteria via the Sec complex and across the outer bacterial membrane. They often possess exceptionally long N-terminal signal sequences. We analyzed 90 long signal sequences of bacterial autotransporters and members of the two-partner secretion pathway in silico and describe common domain organization found in 79 of these sequences. The domains are in agreement with previously published experimental data. Our algorithmic approach allows for the systematic identification of functionally different domains in long signal sequences. Keywords: bacterial autotransporter, sequence analysis, pattern, protein targeting, signal peptide, protein trafficking

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Author:Jan Alexander HißORCiDGND, Gisbert SchneiderORCiDGND
Parent Title (German):Bioinformatics and Biology Insights
Document Type:Article
Date of Publication (online):2010/10/19
Year of first Publication:2009
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2010/10/19
Tag:bacterial autotransporter; pattern; protein targeting; protein trafficking; sequence analysis; signal peptide
First Page:189
Last Page:204
This article is available from © the authors, licensee Libertas Academica Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestricted use, distribution and reproduction provided the original work is properly cited.
Source:Bioinformatics and Biology Insights 2009:3, pp. 189–204
Institutes:Biowissenschaften / Biowissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Sammlung Biologie / Sondersammelgebiets-Volltexte
Licence (German):License LogoDeutsches Urheberrecht