Selenocysteine, pyrrolysine and the unique energy metabolism of methanogenic archaea

  • Methanogenic archaea are a group of strictly anaerobic microorganisms characterized by their strict dependence on the process of methanogenesis for energy conservation. Among the archaea, they are also the only known group synthesizing proteins containing selenocysteine or pyrrolysine. All but one of the known archaeal pyrrolysine-containing and all but two of the confirmed archaeal selenocysteine-containing protein are involved in methanogenesis. Synthesis of these proteins proceeds through suppression of translational stop codons but otherwise the two systems are fundamentally different. This paper highlights these differences and summarizes the recent developments in selenocysteine- and pyrrolysine-related research on archaea and aims to put this knowledge into the context of their unique energy metabolism.

Download full text files

Export metadata

Author:Michael RotherORCiDGND, Joseph A. KrzyckiORCiD
Parent Title (German):Archaea
Publisher:Hindawi Publishing Corporation
Document Type:Article
Date of Publication (online):2010/09/24
Year of first Publication:2010
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2010/09/24
Issue:Article ID 453642
Article Number:453642
Page Number:14
Copyright © 2010 Michael Rother and Joseph A. Krzycki. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Source:Archaea, Volume 2010 (2010), Article ID 453642, 14 pages doi:10.1155/2010/453642
Institutes:Biowissenschaften / Biowissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Sammlung Biologie / Sondersammelgebiets-Volltexte
Licence (German):License LogoCreative Commons - Namensnennung 4.0