Autophagy during vertebrate development
- Autophagy is an evolutionarily conserved catabolic process by which cells degrade their own components through the lysosomal machinery. In physiological conditions, the mechanism is tightly regulated and contributes to maintain a balance between synthesis and degradation in cells undergoing intense metabolic activities. Autophagy is associated with major tissue remodeling processes occurring through the embryonic, fetal and early postnatal periods of vertebrates. Here we survey current information implicating autophagy in cellular death, proliferation or differentiation in developing vertebrates. In developing systems, activation of the autophagic machinery could promote different outcomes depending on the cellular context. Autophagy is thus an extraordinary tool for the developing organs and tissues.
| Author: | Maria Rodriguez Aburto, Juan M. Hurlé, Isabel Varela-Nieto, Marta Magariños |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-300134 |
| DOI: | https://doi.org/10.3390/cells1030428 |
| ISSN: | 2073-4409 |
| Parent Title (English): | Cells : open access journal |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2013/05/23 |
| Date of first Publication: | 2012/08/02 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2013/05/23 |
| Tag: | aging; apoptosis; autophagy; cell differentiation; development; homeostasis; proliferation |
| Volume: | 1 |
| Issue: | 3 |
| Page Number: | 21 |
| First Page: | 428 |
| Last Page: | 448 |
| Note: | © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| HeBIS-PPN: | 346678927 |
| Institutes: | Biowissenschaften / Biowissenschaften |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 59 Tiere (Zoologie) / 590 Tiere (Zoologie) |
| Sammlungen: | Universitätspublikationen |
| Sammlung Biologie / Sondersammelgebiets-Volltexte | |
| Licence (German): |  Creative Commons - Namensnennung 3.0 |
