Characterization of neonates born to mothers with SARS-CoV-2 infection: review and meta-analysis
- Characterization of neonates born to mothers with SARS-CoV-2 infection has been partially carried out. There has been no systematic review providing a holistic neonatal presentation including possible vertical transmission. A systematic literature search was performed using PubMed, Google Scholar and Web of Science up to June, 6 2020. Studies on neonates born to mothers with SARS-CoV-2 infection were included. A binary random effect model was used for prevalence and 95% confidence interval. 32 studies involving 261 neonates were included in meta-analysis. Most neonates born to infected mothers did not show any clinical abnormalities (80.4%). Clinical features were dyspnea in 11 (42.3%) and fever in 9 newborns (19.1%). Of 261 neonates, 120 neonates were tested for infection, of whom 12 (10.0%) tested positive. Swabs from placenta, cord blood and vaginal secretion were negative. Neonates are mostly non affected by the mother's SARS-CoV-2 infection. The risk of vertical transmission is low.
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| Author: | Vanessa NeefORCiDGND, Horst BuxmannORCiDGND, Holger RabenauORCiDGND, Kai ZacharowskiORCiDGND, Florian RaimannORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-575578 |
| DOI: | https://doi.org/10.1016/j.pedneo.2020.10.001 |
| ISSN: | 2212-1692 |
| ISSN: | 1875-9572 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/33334687 |
| Parent Title (English): | Pediatrics and neonatology |
| Publisher: | Elsevier |
| Place of publication: | [Singapore] |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2020/10/24 |
| Date of first Publication: | 2020/10/24 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2020/12/23 |
| Tag: | COVID-19; SARS-CoV-2; infant; neonate; newborn |
| Volume: | 2020 |
| Page Number: | 10 |
| HeBIS-PPN: | 476200474 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |
