Examining volumetric gradients based on the frustum surface ratio in the brain in autism spectrum disorder

  • Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that is accompanied by neurodevelopmental differences in regional cortical volume (CV), and a potential layer‐specific pathology. Conventional measures of CV, however, do not indicate how volume is distributed across cortical layers. In a sample of 92 typically developing (TD) controls and 92 adult individuals with ASD (aged 18–52 years), we examined volumetric gradients by quantifying the degree to which CV is weighted from the pial to the white surface of the brain. Overall, the spatial distribution of Frustum Surface Ratio (FSR) followed the gyral and sulcal pattern of the cortex and approximated a bimodal Gaussian distribution caused by a linear mixture of vertices on gyri and sulci. Measures of FSR were highly correlated with vertex‐wise estimates of mean curvature, sulcal depth, and pial surface area, although none of these features explained more than 76% variability in FSR on their own. Moreover, in ASD, we observed a pattern of predominant increases in the degree of FSR relative to TD controls, with an atypical neurodevelopmental trajectory. Our findings suggest a more outward‐weighted gradient of CV in ASD, which may indicate a larger contribution of supragranular layers to regional differences in CV.

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Author:Caroline MannORCiD, Tim SchäferORCiDGND, Anke BletschORCiDGND, Maria GudbrandsenORCiD, Eileen DalyORCiD, John SucklingORCiD, Edward T. BullmoreORCiDGND, Michael V. LombardoORCiD, Meng-Chuan LaiORCiD, Michael C. CraigORCiDGND, Simon Baron-CohenORCiDGND, Declan G. M. MurphyORCiD, Christine EckerORCiD
Parent Title (English):Human brain mapping
Place of publication:New York, NY
Document Type:Article
Date of Publication (online):2020/12/09
Date of first Publication:2020/12/09
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Contributing Corporation:MRC AIMS Consortium
Release Date:2021/03/02
Tag:autism spectrum disorder; brain anatomy; computational neuroimaging; cortical folding; grey matter volume; gyrification
Page Number:14
First Page:953
Last Page:966
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0