NADPH oxidases in pain processing

  • Inflammation or injury to the somatosensory nervous system may result in chronic pain conditions, which affect millions of people and often cause major health problems. Emerging lines of evidence indicate that reactive oxygen species (ROS), such as superoxide anion or hydrogen peroxide, are produced in the nociceptive system during chronic inflammatory and neuropathic pain and act as specific signaling molecules in pain processing. Among potential ROS sources in the somatosensory system are NADPH oxidases, a group of electron-transporting transmembrane enzymes whose sole function seems to be the generation of ROS. Interestingly, the expression and relevant function of the Nox family members Nox1, Nox2, and Nox4 in various cells of the nociceptive system have been demonstrated. Studies using knockout mice or specific knockdown of these isoforms indicate that Nox1, Nox2, and Nox4 specifically contribute to distinct signaling pathways in chronic inflammatory and/or neuropathic pain states. As selective Nox inhibitors are currently being developed and investigated in various physiological and pathophysiological settings, targeting Nox1, Nox2, and/or Nox4 could be a novel strategy for the treatment of chronic pain. Here, we summarize the distinct roles of Nox1, Nox2, and Nox4 in inflammatory and neuropathic processing and discuss the effectiveness of currently available Nox inhibitors in the treatment of chronic pain conditions.

Download full text files

Export metadata

Author:Wiebke Kallenborn-GerhardtORCiDGND, Katrin SchröderORCiDGND, Achim SchmidtkoORCiDGND
Parent Title (English):Antioxidants
Place of publication:Basel
Document Type:Article
Date of Publication (online):2022/06/14
Date of first Publication:2022/06/14
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/01/24
Tag:NADPH oxidase; Nox; Nox inhibition; inflammation; neuropathy; nociception; pain; peripheral injury
Issue:6, art. 1162
Article Number:1162
Page Number:17
First Page:1
Last Page:17
The authors acknowledge grants from the Else Kröner-Fresenius-Stiftung (2021_EKEA.08 to W.K.-G.) and the Deutsche Forschungsgemeinschaft (SCHM 2629/4-1 to A.S.).
Institutes:Biochemie, Chemie und Pharmazie
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International