Adipogenic activity of chemicals used in plastic consumer products

  • Bisphenols and phthalates, chemicals frequently used in plastic products, promote obesity in cell and animal models. However, these well-known metabolism disrupting chemicals (MDCs) represent only a minute fraction of all compounds found in plastics. To gain a comprehensive understanding of plastics as a source of exposure to MDCs, we characterized all chemicals present in 34 everyday products using nontarget high-resolution mass spectrometry and analyzed their joint adipogenic activities by high-content imaging. We detected 55,300 chemical features and tentatively identified 629 unique compounds, including 11 known MDCs. Importantly, chemicals that induced proliferation, growth, and triglyceride accumulation in 3T3-L1 adipocytes were found in one third of the products. Since the majority did not target peroxisome proliferator-activated receptor γ, the effects are likely to be caused by unknown MDCs. Our study demonstrates that daily-use plastics contain potent mixtures of MDCs and can, therefore, be a relevant yet underestimated environmental factor contributing to obesity. Teaser Plastics contain a potent mixture of chemicals promoting adipogenesis, a key process in developing obesity.

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Author:Johannes VölkerORCiDGND, Felicity Ashcroft, Åsa Vedøy, Lisa ZimmermannORCiDGND, Martin WagnerORCiDGND
Parent Title (English):bioRxiv
Document Type:Preprint
Date of Publication (online):2021/09/01
Date of first Publication:2021/09/01
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/09/14
Page Number:29
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
3 Sozialwissenschaften / 33 Wirtschaft / 333 Boden- und Energiewirtschaft / 333.7 Natürliche Ressourcen, Energie und Umwelt
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International