Update on glycosphingolipids abundance in hepatocellular carcinoma

  • Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer. Low numbers of HCC patients being suitable for liver resection or transplantation and multidrug resistance development during pharmacotherapy leads to high death rates for HCC patients. Understanding the molecular mechanisms of HCC etiology may contribute to the development of novel therapeutic strategies for prevention and treatment of HCC. UDP-glucose ceramide glycosyltransferase (UGCG), a key enzyme in glycosphingolipid metabolism, generates glucosylceramide (GlcCer), which is the precursor for all glycosphingolipids (GSLs). Since UGCG gene expression is altered in 0.8% of HCC tumors, GSLs may play a role in cellular processes in liver cancer cells. Here, we discuss the current literature about GSLs and their abundance in normal liver cells, Gaucher disease and HCC. Furthermore, we review the involvement of UGCG/GlcCer in multidrug resistance development, globosides as a potential prognostic marker for HCC, gangliosides as a potential liver cancer stem cell marker, and the role of sulfatides in tumor metastasis. Only a limited number of molecular mechanisms executed by GSLs in HCC are known, which we summarize here briefly. Overall, the role GSLs play in HCC progression and their ability to serve as biomarkers or prognostic indicators for HCC, requires further investigation.

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Author:Frances L. ByrneORCiD, Ellen M. Olzomer, Nina Lolies, Kyle L. HoehnORCiD, Marthe-Susanna WegnerORCiDGND
Parent Title (English):International journal of molecular sciences
Publisher:Molecular Diversity Preservation International
Place of publication:Basel
Document Type:Article
Date of Publication (online):2022/04/19
Date of first Publication:2022/04/19
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2023/12/13
Tag:GEMs; UGCG; gangliosides; globosides; glucosylceramide; glycolysis; lacto/neo-lacto series GSLs; normal liver cells; oxidative phosphorylation; sulfatides
Issue:9, art. 4477
Article Number:4477
Page Number:13
First Page:1
Last Page:13
This work was funded by the Deutsche Forschungsgemeinschaft (WE 5825/2-1). FB is supported by funding from the Cancer Institute NSW (Career Development Fellowship, 2021/CDF1120).
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International