Sylvia Hartmann, Annette Plütschow, Anja Mottok, Heinz-Wolfram Bernd, Alfred C. Feller, German Ott, Sergio Cogliatti, Falko Fend, Leticia Quintanilla‐Martinez, Harald Stein, Wolfram Klapper, Peter Möller, Andreas Rosenwald, Andreas Engert, Martin-Leo Hansmann, Dennis Alexander Eichenauer
- Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) can present with different histopathological growth patterns. The impact of these histopathological growth patterns on relapse characteristics is unknown. We therefore analyzed paired biopsies obtained at initial diagnosis and relapse from 33 NLPHL patients who had received first‐line treatment within German Hodgkin Study Group (GHSG) trial protocols, and from a second cohort of 41 relapsed NLPHL patients who had been treated outside GHSG studies. Among the 33 GHSG patients, 21 patients presented with a typical growth pattern at initial diagnosis, whereas 12 patients had a variant histology. The histopathological growth patterns at initial diagnosis and at relapse were consistent in 67% of cases. A variant histology at initial diagnosis was associated with a shorter median time to lymphoma recurrence (2.8 vs 5.2 years; P = .0219). A similar tendency towards a shorter median time to lymphoma recurrence was observed for patients presenting with a variant histology at relapse, irrespective of the growth pattern at initial diagnosis. Results obtained from the 41 NLPHL patients who had been treated outside GHSG studies were comparable (median time to lymphoma recurrence for variant histology vs typical growth pattern at initial diagnosis: 1.5 vs 7.0 years). In conclusion, the histopathological growth pattern remains consistent at relapse in the majority of NLPHL cases, and has major impact on the time of relapse.
MetadatenVerfasserangaben: | Sylvia HartmannORCiDGND, Annette Plütschow, Anja Mottok, Heinz-Wolfram BerndGND, Alfred C. Feller, German Ott, Sergio Cogliatti, Falko Fend, Leticia Quintanilla‐MartinezORCiDGND, Harald Stein, Wolfram Klapper, Peter Möller, Andreas RosenwaldGND, Andreas Engert, Martin-Leo HansmannGND, Dennis Alexander Eichenauer |
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URN: | urn:nbn:de:hebis:30:3-559755 |
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DOI: | https://doi.org/10.1002/ajh.25607 |
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ISSN: | 0361-8609 |
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Titel des übergeordneten Werkes (Englisch): | American Journal of Hematology |
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Verlag: | Wiley-Liss |
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Verlagsort: | New York, NY |
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Dokumentart: | Wissenschaftlicher Artikel |
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Sprache: | Englisch |
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Datum der Veröffentlichung (online): | 08.08.2019 |
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Datum der Erstveröffentlichung: | 08.08.2019 |
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Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Datum der Freischaltung: | 05.11.2020 |
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Jahrgang: | 94 |
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Ausgabe / Heft: | 11 |
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Seitenzahl: | 6 |
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Erste Seite: | 1208 |
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Letzte Seite: | 1213 |
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HeBIS-PPN: | 473987988 |
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Institute: | Medizin / Medizin |
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DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Lizenz (Deutsch): | Creative Commons - Namensnennung 4.0 |
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