Caroline Krüger, Ingmar Schäfer, Hendrik van den Bussche, Michael Baehr, Horst Bickel, Angela Fuchs, Jochen Gensichen, Wolfgang Maier, Steffi Gerlinde Riedel-Heller, Hans-Helmut König, Anne Maren Dahlhaus, Gerhard Schön, Siegfried Weyerer, Birgitt Wiese, Wolfgang von Renteln-Kruse, Claudia Langebrake, Martin Scherer
- Background: The elderly population deals with multimorbidity (three chronic conditions) and increasinged drug use with age. A comprehensive characterisation of the medication – including prescription and over-the-counter (OTC) drugs – of elderly patients in primary care is still insufficient.
Objectives: This study aims to characterise the medication (prescription and OTC) of multimorbid elderly patients in primary care and living at home by identifying drug patterns to evaluate the relationship between drugs and drug groups and reveal associations with recently published multimorbidity clusters of the same cohort.
Methods: MultiCare was a multicentre, prospective, observational cohort study of 3189 multimorbid patients aged 65 to 85 years in primary care in Germany. Patients and general practitioners were interviewed between 2008 and 2009. Drug patterns were identified using exploratory factor analysis. The relations between the drug patterns with the three multimorbidity clusters were analysed with Spearman-Rank-Correlation.
Results: Patients (59.3% female) used in mean 7.7 drugs; in total 24,535 drugs (23.7% OTC) were detected. Five drug patterns for men (drugs for obstructive pulmonary diseases (D-OPD), drugs for coronary heart diseases and hypertension (D-CHD), drugs for osteoporosis (D-Osteo), drugs for heart failure and drugs for pain) and four drug patterns for women (D-Osteo, D-CHD, D-OPD and drugs for diuretics and gout) were detected. Significant associations between multimorbidity clusters and drug patterns were detectable (D-CHD and CMD: male: ρ = 0.376, CI 0.322–0.430; female: ρ = 0.301, CI 0.624–0.340).
Conclusion: The drug patterns demonstrate non-random relations in drug use in multimorbid elderly patients and systematic associations between drug patterns and multimorbidity clusters were found in primary care.
MetadatenAuthor: | Caroline KrügerORCiDGND, Ingmar SchäferGND, Hendrik van den BusscheORCiDGND, Michael BaehrGND, Horst BickelGND, Angela FuchsGND, Jochen GensichenORCiDGND, Wolfgang MaierGND, Steffi Gerlinde Riedel-HellerORCiDGND, Hans-Helmut KönigGND, Anne Maren DahlhausGND, Gerhard SchönORCiDGND, Siegfried WeyererORCiDGND, Birgitt WieseORCiDGND, Wolfgang von Renteln-KruseGND, Claudia LangebrakeGND, Martin SchererGND |
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URN: | urn:nbn:de:hebis:30:3-627890 |
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DOI: | https://doi.org/10.1080/13814788.2021.1933425 |
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ISSN: | 1751-1402 |
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Parent Title (English): | European journal of general practice |
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Publisher: | Informa Healthcare/Taylor & Francis |
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Place of publication: | Philadelphia, Pa. |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2021/06/16 |
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Date of first Publication: | 2021/06/16 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2023/10/09 |
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Tag: | Pharmacotherapy; geriatrics; multimorbidity; polypharmacy; primary care |
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Volume: | 27.2021 |
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Issue: | 1 |
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Page Number: | 12 |
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First Page: | 119 |
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Last Page: | 129 |
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Note: | The work was supported by the German Federal Ministry of Education and Research under the grant [numbers 01ET0725-31 and 01ET1006A-K]. |
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HeBIS-PPN: | 51313591X |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
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