Cucumis sativus (Curcubitaceae) inhibits prostate carcinoma cell growth and prevents the testosterone-induced benign prostatic hyperplasia in Wistar rat
- Highlights • Out of the six edible pumpkin seeds found in Cameroonian C. sativus showed most potent anti-proliferative effects on prostate cells. • Its oil conserved almost all the effects of raw seeds and prevented benign prostatic hyperplasia (BPH). • It exhibited potent anti-inflammatory activities in rat with BPH. Abstract Pumpkin seeds are claimed to treat prostate tumour/cancer. The in vitro (ability to inhibit cell growth through MTT assay) and in vivo (ability to prevent testosterone-induced BPH in rats at the doses of 125, 250, 500 and 1000 mg/kg BW) of six edible pumpkin seeds found in Cameroonian were assessed. The endpoints were cell growth arrest, prostate mass and volume, prostatic epithelium height, prostatic proteins, prostate specific antigen (PSA) and inflammatory cytokines. In vitro, C. sativus seeds exhibited the most potent antiproliferative effects on DU145 and PC3 prostate cancer cells and its oil conserved almost all the effects of raw seeds. Further, it prevented the increased of prostate relative mass and volume, prostate epithelium height, PSA and testosterone dose-dependently compared to normal rats. This effect is thought to be mediated through antiandrogenic, estrogenic and anti-inflammatory activities, evidenced by a decreased in IL-1β, IL-6 and TNFα level. Overall, this results justify its traditional use.
Author: | Berlise Yengwa Bakam, Romeo Urich Fosso, Timothy Grein, Derek Tantoh NdintehORCiD, Sebastian MaxeinerGND, Stéphane ZingueORCiD, Roman A. BlahetaORCiD, Dieudonne NjamenORCiD |
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URN: | urn:nbn:de:hebis:30:3-829808 |
DOI: | https://doi.org/10.1016/j.jff.2024.106088 |
ISSN: | 1756-4646 |
Parent Title (English): | Journal of functional foods |
Publisher: | Elsevier |
Place of publication: | Amsterdam |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2024/02/25 |
Date of first Publication: | 2024/02/25 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2024/03/16 |
Tag: | Antioxidant; Antiproliferative; Benign prostatic hyperplasia; Curcumis sativus; Pumpkin seeds |
Volume: | 114 |
Issue: | 106088 |
Article Number: | 106088 |
Page Number: | 13 |
HeBIS-PPN: | 519279808 |
Institutes: | Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |