Scherwin Mahmoudi, Leon David Grünewald, Vitali Koch, Simon Bernatz, Simon S. Martin, Lara Engelskirchen, Ivana Radic, Giuseppe Bucolo, Tommaso D’Angelo, Jennifer Gotta, Christoph Mader, Daniel Pinto dos Santos, Jan-Erik Scholtz, Tatjana Gruber-Rouh, Katrin Eichler, Thomas J. Vogl, Christian Booz, Ibrahim Yel
- Rationale and Objectives: Lumbar disk degeneration is a common condition contributing significantly to back pain. The objective of the study was to evaluate the potential of dual-energy CT (DECT)-derived collagen maps for the assessment of lumbar disk degeneration.
Patients and Methods: We conducted a retrospective analysis of 127 patients who underwent dual-source DECT and MRI of the lumbar spine between 07/2019 and 10/2022. The level of lumbar disk degeneration was categorized by three radiologists as follows: no/mild (Pfirrmann 1&2), moderate (Pfirrmann 3&4), and severe (Pfirrmann 5). Recall (sensitivity) and accuracy of DECT collagen maps were calculated. Intraclass correlation coefficient (ICC) was used to evaluate inter-reader reliability. Subjective evaluations were performed using 5-point Likert scales for diagnostic confidence and image quality.
Results: We evaluated a total of 762 intervertebral disks from 127 patients (median age, 69.7 (range, 23.0–93.7), female, 56). MRI identified 230 non/mildly degenerated disks (30.2%), 484 moderately degenerated disks (63.5%), and 48 severely degenerated disks (6.3%). DECT collagen maps yielded an overall accuracy of 85.5% (1955/2286). Recall (sensitivity) was 79.3% (547/690) for the detection of no/mild lumbar disk degeneration, 88.7% (1288/1452) for the detection of moderate disk degeneration, and 83.3% (120/144) for the detection of severe disk degeneration (ICC = 0.9). Subjective evaluations of DECT collagen maps showed high diagnostic confidence (median 4) and good image quality (median 4).
Conclusion: The use of DECT collagen maps to distinguish different stages of lumbar disk degeneration may have clinical significance in the early diagnosis of disk-related pathologies in patients with contraindications for MRI or in cases of unavailability of MRI.
MetadatenAuthor: | Scherwin MahmoudiORCiDGND, Leon David GrünewaldORCiDGND, Vitali KochORCiDGND, Simon BernatzORCiDGND, Simon S. MartinORCiDGND, Lara Engelskirchen, Ivana Radic, Giuseppe BucoloORCiDGND, Tommaso D’AngeloORCiD, Jennifer GottaGND, Christoph MaderORCiDGND, Daniel Pinto dos SantosORCiDGND, Jan-Erik ScholtzGND, Tatjana Gruber-RouhORCiDGND, Katrin EichlerGND, Thomas J. VoglORCiDGND, Christian BoozORCiDGND, Ibrahim YelORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-834686 |
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URL: | https://www.sciencedirect.com/science/article/pii/S1076633224001272 |
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DOI: | https://doi.org/10.1016/j.acra.2024.02.036 |
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ISSN: | 1076-6332 |
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Parent Title (English): | Academic radiology |
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Publisher: | Elsevier |
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Place of publication: | Amsterdam |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2024/03/22 |
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Date of first Publication: | 2024/03/22 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2024/08/22 |
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Tag: | Collagen Maps; Computed tomography; DECT; Lumbar Disk Degeneration; Post-processing; Spine |
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Volume: | 2024 |
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Issue: | In Press, Corrected Proof |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
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